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Design and Application of Novel Ligand-Induced Split-Protein Systems

This invention is a split protein system that functions as a biotechnological chemically-induced dimerization (CID) tool. These CID systems are useful for biological research to control numerous outputs in living organisms such as inducing the activation of a specific protein, protein localization, and inducing transcription. This novel CID system can...

Published: 6/6/2024 | Inventor(s): Indraneel Ghosh, Samuel Sugerman, Brittany Stankavich

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays

Blood Biomarker for the Diagnosis and Treatment of Chronic Inflammation in the Brain in the Days and Weeks after Stroke

This invention comprises a method of identifying chronic inflammation in the day(s), weeks, or months after a stroke by measuring matrix metalloproteinase-12 (MMP-12) in a patient to determine whether therapeutic intervention is required to help immune cells process lipid debris after stroke to reduce secondary neurodegeneration. MMP-12 is a protein...

Published: 3/12/2024 | Inventor(s): Kristian Doyle

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Protein

Novel Mechanism Anti-Fungal with High Specificity

University of Arizona researchers have discovered a novel approach for treating fungal or yeast infections using a previously unstudied GPCR-like protein, which is integral to the regulation of cell growth in yeast cells. This protein and metabolic pathway is absent in higher-order animals, which provides a novel pathway for drugs to stop the growth...

Published: 3/12/2024 | Inventor(s): Andrew Capaldi, Ryan Wallace, Eric Lu

Keywords(s):

Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases

Protein Structure Analysis using One-Step Tyrosine Conjugation

This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...

Published: 3/12/2024 | Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein

Shelf-Stable Reagent for Bioconjugation and Protein Labeling

This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...

Published: 6/20/2024 | Inventor(s): John Jewett, Garrett Davis, Holly Sofka

Keywords(s):

Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics

Design and Application of New Split-Luciferase Enzymes

UArizona researchers have developed a new split-firefly luciferase enzyme method for measuring protein-protein interactions for assays or sensors. This new method may, when combined with previous split luciferase methods, enable assays for two different protein interactions simultaneously, as well as provide a means for additional biophysical characterization....

Published: 3/12/2024 | Inventor(s): Indraneel Ghosh, Matthew Bienick, Sean Campbell, Carl Buchholz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Protein, Technology Classifications > Life Sciences

Automated Lipid Exchange-Mass Spectrometry System

This invention is an automated label-free method to measure the affinity of membrane proteins for lipids by using conventional small molecule mass spectrometry (MS) to monitor lipid exchange between lipoprotein nanoparticles called nanodiscs. We call this method lipid exchange-mass spectrometry (LX-MS). The concept is that if a membrane protein binds...

Published: 3/12/2024 | Inventor(s): Michael Marty, James Keener, Guozhi Zhang

Keywords(s):

Category(s): Technology Classifications > Research Tools > Protein

Packed Bed Scintillation Particles for Radioisotope Detection and Separations

University of Arizona researchers have developed hydrophilic scintillation microparticles made with polystyrene cores, doped with a scintillator material, and encapsulated with a thin silica coating. The resulting microparticles are hydrophilic and can be easily surface modified to provide a variety of purposes in radioisotope activity detection, such...

Published: 3/12/2024 | Inventor(s): Craig Aspinwall, Minhui Han, Colleen Janczak

Keywords(s):

Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Nanomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation

Powdered G-protein Coupled Receptors

Inventors at the University of Arizona have generated G-protein coupled receptors (GPCRs) lypophilized (freeze-dried) into powdered form. When thawed and rehydrated, these GPCRs retain the functionality of their pre-frozen state even after one year. Because this process also involves the removal of water, the inventors were able to produce thawed GPCRs...

Published: 3/12/2024 | Inventor(s): Michael Brown, Mahakumarage Suchithranga Perera, Udeep Chawla

Keywords(s):

Category(s): Technology Classifications > Research Tools > Protein, Technology Classifications > Materials > Processing

Pseudoprolines in Neuropeptides

This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects. Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides,...

Published: 3/12/2024 | Inventor(s): Robin Polt, Evan Jones

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