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Fluorophore-Doped Metal-Organic Frameworks for Quantifying Low-Energy Radionuclides in Aqueous Solutions
This technology represents a new class of scintillation materials based on metal organic frameworks (MOFs), highly crystalline and tunable structures, which may provide higher detection efficiency compared to other particle scintillation materials. Furthermore, the use of fluorophores with these MOFs paves the way for more versatile applications in...
Published: 4/10/2024
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Inventor(s): Craig Aspinwall, Chen-Yi Ke, Brian Zacher
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Agricultural Engineering, Technology Classifications > Energy, Cleantech & Environmental > Remediation, Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation
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Surface-Modified Electrospray Needles for Mass Spectrometry
With this invention, electrospray needles used in mass spectrometry are coated to prevent sticking and clogging of analytes, resulting in improved mass detection sensitivity and consistency of analysis. The coating comprises an organic material covalently bonded to an interior surface of the electrospray needle. The coating is electrically non-conductive...
Published: 6/20/2024
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Inventor(s): Michael Marty, Craig Aspinwall, Marius Kostelic, Chih-Chieh Hsieh
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Coatings
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Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides
Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Chen-Yi Ke, Minhui Han, Brian Zacher
Keywords(s):
Category(s): Technology Classifications > Materials > Nanomaterials, Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Reagents, Technology Classifications > Medical Devices > Diagnostic
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Packed Bed Scintillation Particles for Radioisotope Detection and Separations
University of Arizona researchers have developed hydrophilic scintillation microparticles made with polystyrene cores, doped with a scintillator material, and encapsulated with a thin silica coating. The resulting microparticles are hydrophilic and can be easily surface modified to provide a variety of purposes in radioisotope activity detection, such...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Minhui Han, Colleen Janczak
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Nanomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation
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Artificial Membranes Incorporating GPCRs for Label-Free, Electrophysiological Measurements of Ligand-GPCR Interactions
This invention consists of an artificial lipid membrane that incorporates G-protein coupled receptors into its structure. It allows direct, label-free measurement of ligand binding and activation of G-protein coupled receptors.
Background:
G-protein coupled receptors are a superfamily of proteins that are very popular drug targets. In 2017, 34%...
Published: 3/12/2024
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Inventor(s): Steven Scott Saavedra, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Screening assays
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A New Method for Preparing Stabilized Lipid Membranes
This invention describes a new straightforward method to prepare stable lipid membranes to maximize its capabilities and usage in the bio/nanotechnology field. The combination of polymer materials via this new polymerization technology that provides stabilized membranes enables new bio/nanotechnology platforms to be realized at its full potential.
Background:
Phospholipid...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Steven Scott Saavedra, Saliya Ratnayaka, Leonard Bright
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Materials > Polymers
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Enhanced Microfluidics PDMS Pneumatic Valve
This invention significantly improves the resistance of pneumatic valves in microfluidic arrays to >500 GΩ (an order of magnitude improvement) with fast opening and reasonable closing times as well as good stability. The result is greatly improved signal-to-noise ratio (SNR) resulting in higher analytical throughput at lower cost.
Background:...
Published: 3/12/2024
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Inventor(s): Xuemin Wang, Christopher Baker, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics
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Rapid Conductance Based Analysis for Patch Clamp Sensors
This invention is a data acquisition and analysis protocol for ligand-ion channel interactions. The approach allows for the quantification of ligand concentrations in less than 30 milliseconds. This approach can monitor rapid, dynamic chemical processes in a feasible manner.
Background:
Ion channels have been researched as an option for label-free...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Steven Scott Saavedra, Mark Agasid
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Rapid Formation of Polymer Frits in Fused Silica Capillaries Using Spatially-Defined Thermal Polymerization
This invention is a novel method of synthesizing porous polymer frits for capillary liquid chromatography using thermal polymerization. This method provides an alternative to current state-of-the art UV cured polymer frits.
Background:
The rapid increase in quality control, research, and drug discovery labs has driven the high performance liquid...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Kendall Sandy, Christopher Baker, Elyssia Gallagher, Boying Liang
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Materials > Polymers, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation
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Stabilized Vesicle-Functionalized Microparticles for Chemical Separations
This invention relates to bioassay platforms, in particular, pull-down assay platforms using silica core-polymerized phospholipid vesicle shell particles for peptide/protein ligand screening.
Background:
Many physiological or pathological events involve the molecular recognition and binding between a peptide/protein ligand and a specific target on...
Published: 6/20/2024
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Inventor(s): Craig Aspinwall, Jinyan Wang, Kendall Sandy, Steven Scott Saavedra, Boying Liang, Christopher Baker, Elyssia Gallagher
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation
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