Latest technologies from University of Arizona

A Neuro-Symbolic Calculus for Quantifying Security Posture in Microservice Architecture

JianlingL@tla.arizona.edu — Wed, 01 Apr 2026 13:21:33 GMT

This technology is a holistic, system-level method for quantifying and explaining the security posture of cloud-native applications built with microservice architectures. To overcome the fragmented observability problem, it analyzes how requests traverse network boundaries across multiple services, generating a multi-dimensional security posture result for each execution path. It fuses multi-source signals combining structural and dynamic evidence reconstructed from the system with business context inferred from code, to capture both the kinetic reality of how the system behaves and the seman...

Shor's Algorithm Implemented on Topological Acoustic Phase Computer

JianlingL@tla.arizona.edu — Mon, 30 Mar 2026 09:31:49 GMT

This technology is a topological acoustic (TA) phase computer. The capabilities of the TA phase computer have been demonstrated through the implementation of Shor’s algorithm. Notably, the TA phase computer is able to implement the algorithm with greater efficiency for a wider range of values than current quantum computing platforms. Using a phase cache, the TA phase computer achieves the algorithm at room temperature. The computer also incorporates an operator spectra shift that enforces the spectral separation of operators to ensure consistent, well-posed mappings between physical mani...

CEDR-API: Productive, Performant Programming of Domain-Specific Embedded Systems

JianlingL@tla.arizona.edu — Thu, 26 Mar 2026 12:47:06 GMT

CEDR (Compiler-integrated, Extensible, DSSoC Runtime) is an application development workflow that enables a more productive and expressive API-based programming methodology for Domain Specific System on Chip (DSSoC) devices. CEDR integrates compile-time application analysis with a runtime system to enable compilation and development of user applications, evaluation of resource management strategies, and validation of hardware configurations in one unified framework that works across open-source systems. Developers can build and test applications on heterogeneous embedded hardware without ...

Systems and Methods for Concurrent Biochemical Immunoassay and Cellular Traction Force Measurement in Hydrogels

JianlingL@tla.arizona.edu — Mon, 23 Mar 2026 10:35:46 GMT

This invention relates to a platform that couples bead-based immunoassays with 3D traction force microscopy (TFM) within a single hydrogel substrate to quantify time-resolved biochemical cues and cell-generated mechanical forces at matched locations. This invention allows researchers to directly test how local molecular cues influence cell mechanics and behaviors. Background: Conventional traction force microscopy (TFM) measures cellular mechanics but does not simultaneously quantify localized biochemical signaling. Current approaches require collecting culture media for separate immuno...

Methods for High-Throughput Alloy Discovery

JianlingL@tla.arizona.edu — Mon, 23 Mar 2026 10:33:31 GMT

This invention involves a software system, platform, and method for high-throughput alloy discovery and screening. It leverages an industrial practice of scrap remelting to systematically harvest chemistry-control samples, followed by storage and recycling. This process can provide higher throughput than conventional alloy synthesis conducted in laboratories. Background: Standard practices for scrap recycling involve sorting material, then remelting and diluting with primary aluminum and other alloying elements until the chemical composition of the melt is within the specification...

Fenotyper

JianlingL@tla.arizona.edu — Mon, 23 Mar 2026 10:29:11 GMT

Fenotyper is an artificial intelligence (AI) based software platform that generates clinical phenotype definitions from plain-language descriptions, leveraging Large Language Models (LLM) and Retrieval-Augmented Generation (RAG). The system converts a researcher’s or clinician’s description of a patient population of interest into a structured definition that can be applied to electronic health record (EHR) data. The platform combines human input with AI reasoning to identify relevant medical concepts and organize them into inclusion and exclusion criteria, allowing experts to revi...

Amine-Based Glycolipid Polymeric Media

JianlingL@tla.arizona.edu — Mon, 23 Mar 2026 10:18:50 GMT

This invention is a family of reusable hybrid polymer materials, made as hydrogels or resin-like beads, designed to remove dissolved metals from water. The materials are built from glycolipid-based building blocks that are modified with metal binding groups, then formed into stable gels, beads, coatings, or thin films. In use, the media is placed in contact with contaminated water so that metals bind to the material, allowing the water to be cleaned and the metals to be collected in a controlled way. A major feature is that the media can be tuned for different use cases. It can be designed to...

Sliding Lunar Emergency Device (SLED)

JianlingL@tla.arizona.edu — Wed, 11 Mar 2026 09:51:12 GMT

This innovation is an emergency, human-powered sled designed for transporting injured astronauts. It is modified for lunar missions with a lightweight, low volume, collapsible, and compact design. The SLED is compatible with NASA's proposed Lightweight Surface Manipulation System for the Human Landing System (HLS). Background: With various organizations, such as NASA, preparing for human operations in lunar environments, emergency preparedness becomes a rising demand. Currently, there are various terrestrial emergency rescue sleds on the market, but none of them are modified s...

Organ-on-Chip Apparatus for Studying and Monitoring Acoustic Wave Interaction with Gas Bubbles and Disruption of Cellular Barriers

JianlingL@tla.arizona.edu — Mon, 09 Mar 2026 10:01:34 GMT

This invention relates to an ultrasound-transparent organ-on-chip platform and a method to study and monitor acoustic wave interaction with gas bubbles and disruption of cellular barriers. The invention can be used for drug screening for ultrasound gas bubble disruption of the blood-brain-barrier (BBB) for brain drug delivery and can be used as a product for research use. Background: Ultrasound-based techniques can transiently open cellular barriers to enable drug delivery, but the underlying bubble-cell-acoustic interactions are complex and are difficult to observe directly in vivo. Un...

Sub-Picosecond Coulomb Implosion of Resonant Nanoscale Structures for Nuclear Fusion

JianlingL@tla.arizona.edu — Thu, 05 Mar 2026 14:39:03 GMT

This invention presents a method of sparking nuclear fusion reactions for energy generations using light-pulse-induced nanostructure dynamics. Igniting fusion reactions at the nanoscale leverages a small amount of input spark energy to achieve a highly localized nuclear fusion energy gain which is capable to ignite a conventional macroscopic nuclear fusion burn producing a million-fold energy gain. Background: This technology builds on multiple converging areas of research: high intensity short pulse coherent light sources, ultrafast light-pulse-matter interactions at nanoscale, nuclear...

Chimeric Inhibitors

JianlingL@tla.arizona.edu — Wed, 04 Mar 2026 13:15:18 GMT

Chimeric PARP/NAMPT inhibitors have been designed to be phosphoribosylated by NAMPT (nicotinamide phosphoribosyltransferase). This modification enriches the cytotoxic adducts held within cancer cells that overexpress NAMPT and significantly increases the safety and efficacy of PARP inhibition, minimizes resistance, and promotes further cancer cell death. Intended to be used in combination with PARP inhibitors. Primary indication is Triple Negative Breast Cancer but can be utilized in all cancers with NAMPT upregulation. Background: Triple-negative breast cancer (TNBC) is the most aggressive f...

Efficient Ce3+–Tb3+ Energy Transfer in BASL-Ce/Tb Co-Doped Glass for Photonic Applications

JianlingL@tla.arizona.edu — Tue, 03 Mar 2026 10:22:01 GMT

This invention describes a method of fabricating novel low-SWaP (size, weight, and power) lasers and magneto-optical devices based on innovative Ce3+/Tb3+ co-doped BASL glass. The ability of this glass to efficiently support energy transfer at wavelengths up to 390 nm, beyond conventional limits, makes it highly promising for use in radiation-hardened visible microchip lasers, non-planar ring oscillators, fiber lasers, and magnetic field sensors. Background: Silicate glasses are popular for their strength, durability, and thermal stability, making them easier to process than other glass...

Broadband Achromatic Waveplate and Polarization Camera for Visible, SWIR, MWIR and LWIR

JianlingL@tla.arizona.edu — Tue, 03 Mar 2026 10:08:08 GMT

This invention uses broadband achromatic waveplates for a wide bandwidth polarimeter and polarization camera to covers visible, short-wave infrared (SWIR), mid-wave infrared (MWIR), and long-wave infrared (LWIR) regions. The design uses low loss optical materials to operate over a large bandwidth range for higher light collection efficiency, which leads to higher signal-to-noise ratio. It also measures the complete Stokes parameters and has broad end-use application in remote sensing, microscopy, industrial metrology, night vision, surveillance, and medical diagnostics. Background: Pola...

OAM-based Entanglement Assisted Free-Space Optical Communication with Unknown Receiver Position

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 09:04:42 GMT

This technology relates to a combination of an entanglement-assisted free-space optical communication testbed and orbital angular momentum (OAM)-based beam shaping to acquire and communicate with receivers whose exact position is unknown, covering a wide search area in strong turbulence regime. Background: Establishing a free-space optical (FSO) communication link between communicating parties becomes difficult when the transmitter does not know the precise location of the receiver. While many current methods entail locating the target and determining its position, this technology offer...

Task-Oriented Efficient Measure of Reservoir Computing Power

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 09:02:07 GMT

This technology addresses gaps in existing reservoir computing technologies by establishing mathematical bounds on computational expressivity and analyzing factors such as reservoir dynamics, generalization capabilities, and limitations in temporal processing. The technique allows suitable reservoirs to be rapidly selected in order to build efficient learning machines that can be used in mainstream artificial intelligence applications. Background: Artificial intelligence systems have become the backbone of modern data processing, but these systems require large amounts of computa...

Glycocalyx Mimetics

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 09:00:55 GMT

This invention involves a type of medical tube/tubing or catheter with a glycocalyx mimetic coating to prevent blood clotting. Background: The endothelial glycocalyx is a dynamic surface layer of vascular endothelial cells, of vascular endothelial cells, acting as a critical, multi-functional barrier for vascular health. It maintains vascular homeostasis by regulating permeability, mechanosensing, and preventing blood cell adhesion (preventing thrombosis and inflammation). Currently, there is a lack of available and reliable glycocalyx-mimetic coatings on vascular devices,...

iDance-Cog Card Game

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 08:59:56 GMT

The iDance-Cog Card Game is an evidence-based and evidence-informed movement game that combines illustrated movement cards, spinning wheels, and dice to create an engaging, rhythm-based play experience. The game is designed to enhance attention, reaction time, memory, coordination, and cognitive flexibility in players through movement sequences performed at varying tempos. Players respond to movement prompts in synchrony with rhythmic beats of adjustable speeds and difficulty levels. The modular design allows for adaptable gameplay across age groups and settings, including home use, classrooms...

AI Virtual Explorer for Research, Discovery, and Education (AI-VERDE)

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 08:58:53 GMT

This technology is a unified LLM-as-a-platform service (LLMPaaS) designed to facilitate seamless integration of commercial, cloud-hosted, and on-premise open LLMs in academic settings. AI-VERDE streamlines access management for instructional and research groups by providing features such as robust access control, privacy-preserving mechanisms, native Retrieval-Augmented Generation (RAG) support, budget management for third-party LLM services, and both a conversational web interface and API access. Background: The majority of LLM access today is either individual or enterprise-oriented, ...

Systems and Fabrication Methods for Resistor Designs Through Printing

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 08:57:53 GMT

This invention involves a fabrication method for directly embedding customized resistors into a 3D printed object. This entails using multiple low conducive filaments in order to flexibly customize the resistance of a trace, that acts as a resistor, printed through the combinations of the various low and medium range conductive filaments. Background: Currently, existing technology-based resistor embedding systems use high-ranging conductive filaments in order to 3D print or fabricate. These methods require a long trace to achieve a particular resistance and are controlled solely b...

Combining Plasmonic Nanostructures and Machine Learning to Detect and Modulate Protein Aggregation

JianlingL@tla.arizona.edu — Mon, 02 Mar 2026 08:56:56 GMT

This innovation is a nanotechnology- and artificial intelligence-powered platform that combines plasmonic gold nanomaterials (AuNMs) with machine learning (ML) to achieve high-throughput, selective, and broad-spectrum identification of potential inhibitors of amyloid beta aggregation. Proof of concept testing found that the platform can identify spectral features corresponding to early and late aggregation phases to accurately predict the specific stages of amyloid beta aggregation, which has not been demonstrated with similar screening methods. This innovation has the potential to extend to t...

Radiatively Cooled Superconducting Power Distribution for Solar-Powered Space Systems

JianlingL@tla.arizona.edu — Fri, 27 Feb 2026 08:28:43 GMT

This invention is a solar-powered space system configured to reduce or eliminate resistive losses during high-current DC power delivery using its superconducting power distribution combined with passive radiative cooling and a working fluid thermal loop. Background: Solar photovoltaic arrays, which generate direct current (DC) power, are the primary electrical power source for spacecraft, satellites, and space-based computing. DC power transmission involves large currents, which result in non-negligible resistive losses in the wiring, connectors, and bus structures. In space, thes...

Layer-Engineered Frustrated Total Internal Reflection (FTIR) Sensors for Structural Integrity and Tamper Detection

JianlingL@tla.arizona.edu — Fri, 27 Feb 2026 08:26:59 GMT

This technology is a thin, multilayered optical sensor designed to detect physical damage, tampering, or material loss before failure occurs in microelectronics, aerospace, and advanced packaging platforms. It uses light, rather than electrical signals, to passively monitor whether a structure has been disturbed. When a layer is thinned, cracked, deformed, or contacted by an external object, the sensor produces a clear optical change that can be read as an on/off signal. This makes it well-suited for early warning and tamper detection in sensitive systems. Unlike many optical sensors that reac...

Optical Physical Unclonable Function (PUF) Based on BEOL-Induced Random Transfer Function

JianlingL@tla.arizona.edu — Fri, 27 Feb 2026 08:26:31 GMT

This invention is a hardware security technology that creates a unique and unclonable fingerprint for each semiconductor chip. It uses natural manufacturing variations in the back-end-of-line (BEOL) layers of a CMOS device to produce a chip-specific optical response when illuminated with light. The resulting optical pattern acts as a secure identifier that can be used for authentication or key generation. Since the randomness comes from standard fabrication variations, no special materials or custom photonic layers are required, making this approach practical and cost-effective for large-scale...

BEOL-Optical Tamper Detection in CMOS Packaging and BEOL Structures

JianlingL@tla.arizona.edu — Fri, 27 Feb 2026 08:26:07 GMT

This invention is a hardware security technology that detects physical tampering of semiconductor chips at a very early stage. It embeds optical sensing features within the back-end-of-line (BEOL) and packaging layers of standard CMOS devices. These features produce a stable optical response during normal operation, but the response changes immediately when the physical structure of the chip is disturbed. By monitoring this optical behavior in real time, the system can detect tampering as soon as protective layers are altered. This allows the device to trigger defensive actions before sensitiv...

Solar Ultraviolet (SUV) Water Treatment Design

JianlingL@tla.arizona.edu — Thu, 26 Feb 2026 13:20:42 GMT

The Solar Ultraviolet (SUV) Water Treatment Design is a solar-powered water disinfection system that uses ultraviolet (UV) light to reduce harmful microorganisms in drinking water. It is intended for use in locations without dependable electricity, including remote communities and emergency situations. The system treats water by exposing it to UV light and allows the water to circulate through the treatment process as needed to improve disinfection. This invention is noteworthy for its focus on reliability under real-world conditions. The recirculation-based design helps maintain effective tre...

Method of Treating HFpEF

JianlingL@tla.arizona.edu — Mon, 23 Feb 2026 08:51:56 GMT

This technology is directed to a method of treating heart failure with preserved ejection fraction (HFpEF) by using a compound that mimics the effect of titin phosphorylation at the N2B segment. This technology has the potential to discover drugs for treating heart failure patients with stiff hearts and declined filling capacity. Background: About half of all heart failure patients suffer from excessive cardiac stiffness, which limits the heart’s ability to fill properly. There is a pressing need for therapies that reduce this stiffness, yet none currently exist. Titin plays a maj...

Underwater Localization Utilizing Microwave Induced Thermoacoustic Signals

JianlingL@tla.arizona.edu — Wed, 18 Feb 2026 10:48:07 GMT

This invention involves using remote microwave sources to generate thermoacoustic pulses coded with precise location and timing information to compute an underwater vehicle’s position. This localization system uses hydrophones to receive and decode embedded information from the signals to compute their position through multilateration. The system creates an ad-hoc, GPS-like constellation of acoustic signals that can be reconfigured dynamically, enabling flexible deployment for a range of applications, including defense, commercial use, and research. Background: Currently, localiza...

Rapid Partial-Measurement Mueller Matrix Imaging of the In Vivo Human Eye

JianlingL@tla.arizona.edu — Mon, 16 Feb 2026 08:28:30 GMT

This invention describes a method of creating a full Mueller matrix of the eye with fewer than 16 polarization measurements. This partial measurement approach reduces the overall data acquisition time, an important advantage considering the rapid temporal variations of the eye. Background: Being able to accurately assess the optical properties of the human eye is essential for diagnosing corneal disorders and monitoring eye disease progression. Many structures in the anterior segment of the eye exhibit polarization-dependent behavior that traditional imaging systems cannot capture. Exis...

CRISPR-Cas13-Based Isothermal Assay for Multiplex Detection of Circulating MicroRNAs from Small-Volume Blood Samples

JianlingL@tla.arizona.edu — Mon, 16 Feb 2026 08:27:03 GMT

This invention relates to the field of molecular diagnostics and nucleic acid detection. In particular, it concerns an isothermal assay platform for the multiplex detection of circulating microRNAs (miRNAs) in small-volume blood samples. The platform is useful for early detection, screening, or monitoring of diseases such as cancer and other conditions. Background: Small noncoding RNAs, known as microRNAs (miRNAs), control the expression of genes that code for proteins by either cleaving RNA transcripts or suppressing translation. Numerous types of malignancies have been shown to have a...

Chatbot Interaction Personalization

JianlingL@tla.arizona.edu — Mon, 16 Feb 2026 08:26:14 GMT

Chatbot Interaction Personalization is a framework for tailoring large language model–based chatbot interactions to individual patients using retrieval augmented generation (RAG). Instead of retraining or fine-tuning the underlying model, the system ingests persona descriptions or curated conversation fragments and uses them as a retrieval layer that shapes each response, allowing the chatbot to adjust tone, content emphasis, and examples to match user needs. Clinicians or care teams define persona profiles and the system automatically tailors interaction style and information accordingl...

Privacy Preserving Diagnosing

JianlingL@tla.arizona.edu — Mon, 16 Feb 2026 08:25:04 GMT

Privacy Preserving Diagnosing converts patient videos into standardized avatar representations that retain clinically relevant movement, posture, and facial cues while removing identifiable visual details. These neutral avatars serve as input for machine learning-based diagnosis models–with initial work in autism spectrum disorder (ASD)–demonstrating high classification performance. The system separates visual identity from the behavioral signal needed for diagnosis, creating a de-identified dataset that can be stored, shared, and analyzed with substantially lower privacy risk than...

LLM-Generated Authorization Tests for Microservices

JianlingL@tla.arizona.edu — Tue, 10 Feb 2026 15:40:54 GMT

This invention is a policy-grounded framework that produces executable, downstream-aware authorization tests that can detect drift across microservice chains more reliably than existing automated test generators. Background: Modern software has largely transitioned from monolithic designs to microservice architectures. This means an application is made up of dozens of modular services that communicate via APIs. This results in traffic that is very difficult to secure because each service must independently verify user permissions. Traditional security tools are ineffective because...

Radiative Pre-Cooling of Isolated Seawater for Thermal Management Systems Including Data Centers

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:48:02 GMT

This invention uses nighttime radiative cooling applied to isolated seawater reservoirs to enhance cooling performance in order to significantly improve large thermal-load facilities cooling performance. The design is compatible with large-scale, warm climate data center deployments and provides a novel approach to reducing operational energy consumption. Background: The radiative cooling of fresh water and treated water is widely studied and implemented in building-scale applications. Seawater is well-established as a thermal reservoir for industrial cooling. However, no existing syste...

Wavelength Division MUX/DEMUX Using On-Chip Sagnac Loop Based Fabry Perot Cavities

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:47:32 GMT

This invention relates to integrated photonic devices for wavelength division multiplexing (WDM). The architecture implements an array of Fabry-Perot cavities formed using Sagnac loop reflectors as mirrors. Each cavity is side-coupled to a waveguide that carries a broadband optical signal, which ultimately enables multi-channel WDM operation. Background: The growing demand for high-speed data transmission and bandwidth efficiency has driven the need for reliable wavelength management solutions. Traditional wavelength division multiplexing approaches, such as arrayed waveguide gratings o...

Athermal On-Chip Cavities and Filters Using Sagnac Loop Reflectors

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:47:03 GMT

This invention replaces traditional Fabry-Perot mirrors with Sagnac loop reflectors where the reflections from the loop have a phase response that depends on both the waveguide index and loop radius. These are both temperature-dependent properties, meaning that by choosing the right loop size and waveguide geometry, the phase drift from the mirrors can be designed to cancel the thermal drift of the cavity itself, resulting in an athermal Fabry–Perot cavity. Background: A central challenge in the silicon photonics market is maintaining stable optical performances in integrated devi...

Metasurface-Based Dual-Axis Polarization Beam Splitter for Entanglement Verification

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:46:22 GMT

This invention describes a nanophotonic element that simultaneously performs two distinct polarization-sorting operations. Each photon incident on the device is directed to one of four quadrants in the far field or focal plane and are uniquely encoded based on their polarization outcome in both the linear and circular bases in a single measurement, rather than in sequential basis settings. Background: Polarization-entangled photons are important in quantum information technologies such as secure communications and computing. As these applications rely on genuine quantum correlatio...

Metasurface-Based Bell State Analyzer

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:44:35 GMT

This technology is an ultra-compact, single, flat, nanostructured surface that acts as a complete quantum state analyzer with the capability of separating photons based on their polarizations and then directing them to a set of outputs. This invention acts as a built-in quantum interferometer for photon pairs and can uniquely identify all four possible quantum states with 100% theoretical accuracy in a single measurement without moving parts or active control. Background: Quantum photonics is a rapidly advancing field at the intersection of quantum information science and nanotech...

Fusarivir: a Bacterial Delivery Mechanism to Insert Mycoviruses into Fusarium Oxysporum

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:35:06 GMT

This invention is a platform for delivering mycoviruses—viruses that infect fungi—directly into fungal cells using engineered bacteria. Due to the absence of a protein shell, mycoviruses require a delivery mechanism to enter fungal cells and suppress host pathogenicity. This method utilizes an intrahyphal bacterium, which enters fungal hyphae leading to lysis of the bacterial cells and the subsequent release of fungal viruses into the fungi, where they selectively infect pathogenic fungi. The platform is broadly applicable to deliver any mycovirus into compatible fungal hosts, with...

Dark Eye Harvester

JianlingL@tla.arizona.edu — Mon, 09 Feb 2026 08:33:00 GMT

This invention involves using an insulated light-proof chamber that allows the harvesting of eyes or another light-sensitive biomaterial without light exposure, allowing visual rhodopsin to regenerate more efficiently. The chamber has a cylindrical shape and is attached to a chest cooler with handles on top to rotate the walls. The chamber has multiple compartments relating to each stage of harvesting the eye including a dark cooler, preventing light from getting into the cooler while adding new biomaterial. Background: Rhodopsin is a key light-sensitive protein expressed exclusiv...

Deterministic Fabrication of Site-Controlled Semiconductor Quantum Dots

JianlingL@tla.arizona.edu — Thu, 05 Feb 2026 15:11:45 GMT

This technology is a novel technique for the manufacturing of site-controlled GaAs (gallium arsenide) quantum dots (QDs) used in quantum communication and quantum computing. This technique uses an improved local droplet etching (LDE) method. This method allows for control over the location of quantum dot formation. A key innovation of this method is its ability to leverage LDE to remove extrinsic defects introduced during the growth process. This enhancement addresses prior challenges with site-controlled QD fabrication, ensuring superior optical properties and consistency across the array. &n...

In Line Feedthrough Microwave Reactor With Gradient Mixer And Specific Gravity Separation Unit For Graphene Exfoliation

JianlingL@tla.arizona.edu — Thu, 05 Feb 2026 07:38:06 GMT

Title: In-line Feedthrough Microwave Reactor Unit for Graphene Exfoliation Invention: This invention is an in-line feedthrough microwave reactor with static mixture and gradient flow geometry that proposes a static mixture and can be used to mass manufacture graphene from purified natural graphite. The static mixture has improved gradient geometry blades that enable the machine to efficiently mix the raw graphite with exfoliating agents and can accommodate a large volume. Once the output is produced, it is then fed to a specific gravity station with a specific gravity gradient that is use...

Simultaneous Bilateral Breast Imaging without Compression using Offset Detector

JianlingL@tla.arizona.edu — Wed, 04 Feb 2026 09:08:59 GMT

This invention involves an upright cone-beam breast computed tomography (CT) designed to image two breasts simultaneously with high resolution. The design prevents patients from having to reposition their bodies between images. Additionally, this invention builds on the deep learning algorithm for breast CT image reconstruction. Background: Present mammography and tomosynthesis methods typically only image one breast at a time at limited angles and require breast compression, causing patient discomfort. Additional movement from patients during imaging can cause artifacts in images...

Topological Acoustic Synapse for High-Dimensional Neuromorphic Computing

JianlingL@tla.arizona.edu — Tue, 03 Feb 2026 09:20:51 GMT

The Topological Acoustic Synapse is a neuromorphic hardware device that uses acoustic waves to perform high-dimensional neuromorphic computing. The device encodes information in a multivariate state space and uses nonlinear acoustic wave interactions to reproduce synapse-like behavior for computation. By shifting key functions from purely electronic signaling to acoustic-wave interactions, the technology is intended to provide parallel processing, rapid convergence with fewer parameters, and ultra-low power operation. It is also designed to reduce wiring complexity and hardware footprint while...

Frequency-Selective Topological Wave Switches Using Anti-Resonance Control

JianlingL@tla.arizona.edu — Mon, 02 Feb 2026 10:11:20 GMT

This technology is a materials-based method of controlling acoustic wave propagation using anti-resonance control. By integrating phase-change inclusions into acoustic metamaterials, this technology provides a material that allows bidirectional signal transport at certain frequencies and only unidirectional transport at other specific anti-resonance frequencies. This enables the development of devices and sensors, including reconfigurable RF filters, directional acoustic switches, non-reciprocal devices, and adaptive signal processing systems that can switch between bidirectional and unidirect...

Inhibitory Monoclonal Antibodies Against Factor XII(a) and Method of use for Treatment of Dilated Cardiomyopathy and Heart Failure

JianlingL@tla.arizona.edu — Mon, 02 Feb 2026 10:10:01 GMT

This invention details how to make and utilize monoclonal antibodies that bind to and inhibit the activity of the coagulation factor Factor XII (FXII, FXIIa) protein, and methods of use for treatment of dilated cardiomyopathy and heart failure. Background: Approximately 6.7 million Americans over 20 years of age experience heart failure, and the prevalence is expected to rise to 8.5 million Americans by 2030, with dilated cardiomyopathy being a leading cause. The demand for improved therapeutics grows at the lifetime risk of heart failure has increased to 24%; approximately 1 in 4 indiv...

Zernike Mode Sorting with Vortex Phase Filtering

JianlingL@tla.arizona.edu — Mon, 02 Feb 2026 10:08:30 GMT

This invention uses vortex filters, used in conjunction with single-mode converters, to spatially sort real and complex-valued Zernike polynomials and function as an arbitrary spatial mode sorter. Background: Optical systems rely on the precise manipulation of complex light fields. Conventional wavefront sensing and mode decomposition techniques do not efficiently distinguish between modes in real time. Many of the existing traditional solutions, such as interferometric setups or spatial light modulators, are bulky, slow, and sensitive to alignment errors. There has been a recent ...

Method and Device for 3D Imaging

JianlingL@tla.arizona.edu — Mon, 26 Jan 2026 08:13:31 GMT

This technology combines spatio-temporal structured light patterns with emerging high-speed asynchronous event focal plane arrays to enable rapid 3D imaging. With this technology, spatio-temporal structured light patterns with unique properties are rapidly projected onto the scene using a high-speed spatial light modulator. The asynchronous events recorded on edge devices at each pixel with time-to-digital converters (TDCs) uniquely encodes the 3D coordinates of the imaging scene. This platform enables direct 3D image recovery with accuracy comparable to structured light systems, but at signif...

Chip-Scale Digital Holographic Platform

JianlingL@tla.arizona.edu — Mon, 26 Jan 2026 08:12:50 GMT

This technology is a compact digital holography device using flat optics to achieve high-fidelity wavefront interference and lens-based object imaging. This design minimizes optical volume while improving system stability and enables the integration of digital holography into portable or embedded systems where space is at a premium. The system is modular and adaptable, making it compatible with a wide range of existing imaging setups. Background: Holography technology is widely employed in applications such as machine vision, biomedical sensing and advanced imaging, and more. Howe...

Smart Vision: AI-Powered Ocular Ultrasound for Real-Time Retinal Detachment Detection

JianlingL@tla.arizona.edu — Mon, 26 Jan 2026 08:08:37 GMT

Smart Vision is an AI-enhanced ocular ultrasound diagnostic system to screen patients for retinal detachment. Smart Vision uses a deep learning system based on ultrasound data to assess macular status and determine if a patient is experiencing retinal detachment. This allows a wider range of medical professionals to perform screening for retinal detachment, while current systems require specially trained ophthalmology providers to perform initial screenings. This could enable earlier detection of retinal detachment, which would significantly improve patient outcomes. Background: R...

Standoff Barcode Reader that uses an Entangled Transmitter (Light-Squeeze-o-Matic-Barcode-Readatron R)

JianlingL@tla.arizona.edu — Fri, 23 Jan 2026 09:09:39 GMT

This technology is a barcode reader that utilizes an entangled transmitter that allows better performance especially when the detected light has undergone loss and noise. Background: When the observed light has been subjected to loss and noise on its way to the receiver, entanglement-assistance improves efficiency in discrimination and communication tasks the most. This means that a barcode reader with entanglement-assisted reading can read barcodes from a long distance. This technology could be used with LIDAR-based sensors to identify scenes without completely resolving them because detecti...

Inhibition of Metastasis in Triple Negative Breast Cancer

JianlingL@tla.arizona.edu — Wed, 21 Jan 2026 08:36:07 GMT

This invention uses a therapeutic peptide sequence that inhibits breast cancer metastasis by activating natural killer (NK) cells against breast cancer cells. This inhibitor can be used to treat triple-negative breast cancer metastasis, associated with excess epidermal growth factor receptor (EGRF) which is overexpressed and amplified in 60% of triple-negative breast cancer patients. The inventor observed changes in the immune system of this peptide treatment, specifically, how cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells seem to be activated in the immune microenvironment and...

CLEO-AI: Closed-Loop Edge System for Optimized and Adaptive Intelligence

JianlingL@tla.arizona.edu — Tue, 06 Jan 2026 15:05:39 GMT

CLEO-AI is a closed-loop edge artificial intelligence framework that allows resource-limited devices to learn, optimize, and redeploy models in real time without cloud dependence. It combines on-device model growth, training-free compression, and a hardware-agnostic runtime, enabling systems-on-chip (SoCs) to adapt to changing data or environments while maintaining strict Size, Weight, and Power (SWaP) constraints. CLEO-AI delivers low latency and high reliability for edge operations where bandwidth is limited or unavailable. At its core, CLEO-AI integrates an Adaptive Learning System that ex...

High Resolution 3D Imaging of Diamonds with Multiphoton Microscopy

JianlingL@tla.arizona.edu — Tue, 06 Jan 2026 15:04:55 GMT

This invention describes a method of using multiphoton microscopy (MPM) for 3-dimensional imaging and spectral analysis of natural and synthetic diamonds, as well as diamond-like simulants. This non-destructive approach provides insights into the interior structure, fluorescent defects, and formation conditions of diamonds. This method can be used to investigate gemstone quality and may trace gemstone provenance and treatment history. Background: Diamonds offer unique benefits for optical technology development due to their optical, chemical, electrical, mechanical, and thermal properti...

Morphable Multicopter UAS (MMU)

JianlingL@tla.arizona.edu — Tue, 06 Jan 2026 15:04:01 GMT

This technology is a morphable multicopter uncrewed aerial system (UAS) or “MMU.” The MMU consists of a link-joint structure connecting powered cells (with rotors) and unpowered cells carrying payloads. The structure can safely change shape, deforming to navigate narrow spaces. The MMU is equipped with precise cell location control enabling low-cost, accurate localization and the reliable execution of shape-changing movements. This morphable multicopter is robust and durable, with enhanced structural rigidity and redundancies in power generation. The MMU is capable of stably carryi...

Isolation and Separation of Angiotensin I and II from Human Serum Using a New Chromatographic Matrix that Excludes High Molecular Weight Proteins

JianlingL@tla.arizona.edu — Tue, 06 Jan 2026 15:03:04 GMT

This innovation introduces a novel chromatographic matrix that effectively isolates and separates angiotensin I and II, key biomarkers involved in blood pressure regulation, from human serum. The system uses a hybrid combination matrix that selectively removes small molecular weight polypeptides while excluding large serum proteins. By integrating chelating agents with metal ions and polymers of varying molecular weights, the matrix enables highly efficient separation and quantification of these peptides. This process allows precise monitoring of angiotensin levels and has potential to help re...

Analytical Technology for the Isolation of 3-Nitrotyrosine as a Biomarker from Urine to Assess Depression and Acute Kidney Injury

JianlingL@tla.arizona.edu — Tue, 06 Jan 2026 15:02:24 GMT

This invention uses a novel separation technique to isolate specific biomarkers from urine, as a measure to detect and monitor depression and acute kidney injury (AKI). The system employs a hybrid chromatographic matrix that rejects biomolecules of specific sizes and allows only the desired small compounds, such as 3-nitrotyrosine (which has been linked to kidney injury and depression), to penetrate and interact with affinity groups previously attached to the matrix. This streamlined process provides the foundation for urinary-based diagnostic tests that can support early detection and monitor...

Therapeutic Target of Ewing Sarcoma by G-Quadruplex Binding Compound

JianlingL@tla.arizona.edu — Tue, 06 Jan 2026 15:01:25 GMT

This innovation identified lead molecules that target specific nucleic acid structures involved with forming G-Quadruplex structures. These G-Quadruplex structures are a highly stable nucleic acid fold with planar stacks of guanine tetrads which regulate genome stability, transcription, and telomere maintenance. This innovation details a therapeutic method that targets and prevents the proliferation and malignant growth in Ewing sarcoma. Background: Ewing sarcoma is a rare type of cancer that begins as a growth of cells in the bones and the soft tissue around the bones. While it h...

Novel Therapy for Ischemic and Pressure-Overload Heart Diseases

JianlingL@tla.arizona.edu — Fri, 12 Dec 2025 07:36:29 GMT

This novel therapy involves using valosin-containing protein (VCP) to prevent or treat ischemic and pressure overload-induced heart disease. Inactivation and reduced VCP expression are highly associated with multiple cardiac diseases. Overexpression of VCP in the heart has been found to reduce infarct size during ischemia-reperfusion injury and also protect against pressure overload-induced cardiomyopathy and heart failure (HF). VCP protects against these diseases through comprehensive mechanisms, such as promoting cardiomyocyte survival signaling, preserving mitochondrial energy production, p...

Intelligent Solar Window Frame (ISoW Frame aka JoMactt Window) for Buildings on the Earth, Moon, Mars and Beyond

JianlingL@tla.arizona.edu — Mon, 08 Dec 2025 09:01:49 GMT

The JoMactt Window is an intelligent solar window solution made up of many individual laminated glass units, each one containing multiple retractable quantum dot layers. Each unit has different quantum dot densities and transparencies that can be altered to vary the unit’s solar electricity conversion efficiency. Only one of the glass units in a window operates at any given time, and is chosen based on whether greater transparency or greater electricity generation is desired at that time. If a normal, totally transparent window is desired at any point, the glass units can be retracted to...

Adaptive Spatial Mode Correction for Free-Space Optical Communication Without Reference Beams

JianlingL@tla.arizona.edu — Mon, 08 Dec 2025 09:00:49 GMT

This invention provides a guide-star-free adaptive correction method for free-space optical (FSO) communication links. The system employs a high-speed spatial light modulator or equivalent adaptive optical element to detect and correct turbulence-induced distortions directly from the communication signal. By continuously optimizing a signal-quality metric in real time, the system maintains mode purity and mitigates crosstalk without the need for additional reference channels. This advancement enables efficient, high-bandwidth optical communication between satellites and between satellites and ...

Radiation-Hardened Nanophotonic Thermal Emitters with Spectral and Angular Selectivity for Spaceborne Radiative Cooling

JianlingL@tla.arizona.edu — Mon, 08 Dec 2025 09:00:15 GMT

This technology introduces a radiation-hardened nanophotonic surface engineered for high-efficiency radiative cooling in low Earth orbit (LEO). The metasurface employs angular and spectral selectivity to maximize emission toward deep space while minimizing absorption of sunlight and planetary infrared radiation. Constructed from refractory and ceramic materials that withstand ultraviolet and charged-particle exposure, the design maintains stable performance over long-duration missions. The result is a robust, lightweight, and highly efficient thermal emitter suitable for spacecraft with demand...

Passive Radiative Cooling System for Enabling Superconducting Electronics and Interconnects in Space-Based Computing and Communication Systems

JianlingL@tla.arizona.edu — Mon, 08 Dec 2025 08:59:43 GMT

This invention presents a passive thermal management system designed to sustain superconducting electronics and interconnects in orbit without the need for active refrigeration. The system employs a large, space-facing radiative shield to cool a circulating working fluid to cryogenic temperatures. The cooled fluid maintains superconducting components below their critical temperature, eliminating electrical resistive losses and significantly reducing heat generation during high-speed data processing. By removing these resistive losses, the technology minimizes the spacecraft’s overall the...

Dual-Mode Micro-Coil Ising Machine Using Magnetic Nanoparticles

JianlingL@tla.arizona.edu — Mon, 08 Dec 2025 08:59:01 GMT

This invention is a hardware Ising machine that uses a micro-coil array and magnetic nanoparticles acting as binary spins. The micro-coils apply magnetic fields to program the spins of the magnetic nanoparticles and then act as sensors that measure the induced spins. When the magnetic nanoparticles interact through dipole-dipole interactions, they provide the coupling terms of an Ising Hamiltonian to solve optimization problems. Background: Ising machines are hardware platforms that solve complex optimization problems by mapping them onto spin systems that naturally move towards l...

SAGE: A Low-Cost, High-Throughput Disease Agnostic Microfluidic Discovery Engine

JianlingL@tla.arizona.edu — Mon, 08 Dec 2025 08:58:02 GMT

This technology relates to a low-cost, high throughput microfluidic platform device which can help identify therapeutic compounds from a known agent, such as tuberculosis. Through a three-chip process, the invention can encapsulate, cultivate, screen and sort bacteria from a host of environmental microbes for bioactive natural products. The platform is disease agnostic, enabling a wide range of diagnostic capabilities, and provide equal if not better throughput than conventional liquid handling robots. Background: New paradigms and technological approaches enabling rapid and informed di...

Human-Governed Control of Digital Thread Data

JianlingL@tla.arizona.edu — Tue, 02 Dec 2025 09:20:37 GMT

This innovation introduces a novel methodology for Digital Engineering wherein data is aggregated rather than propagated and provided to a human engineering manager for decision making purposes. Unlike the current paradigm, this approach aims to consolidate information without automatically disseminating it across models, providing a more effective means of handling interconnected models from heterogeneous disciplines. This process enables a more robust and flexible system without automatically imposing consistency that enhances the overall effectiveness of Digital Engineering. Background:&nb...

Multi Polish Robot Polishing Method

JianlingL@tla.arizona.edu — Mon, 01 Dec 2025 11:21:24 GMT

This invention is for a robotic system that is designed to polish multiple regions of a large optical surface simultaneously. It includes a novel internal propulsion mechanism that uses coils to drive a magnetic weight along a circular track. This method can accelerate the mirror fabrication time, eliminating the need for off-line testing, reducing downtime and improving overall efficiency. Background: Conventional polishing of meter-class optics can take several years to complete and often is a bottleneck in preparing mirrors for large telescopes. This novel method uses a...

A Flexible, Scalable Platform Technology to Augment Antibiotic Efficacy

JianlingL@tla.arizona.edu — Mon, 01 Dec 2025 08:22:10 GMT

This invention relates to a novel, safe, and efficacious approach to reduce antibiotic concentrations required to kill pathogenic bacteria. The product thus augments antibiotic efficacy, including against bacteria that are clinically resistant. Background: One of the biggest risks to global public health is antibiotic resistance. Through processes like enzymatic breakdown, efflux pumps that remove antibiotics from the cell, decreased permeability of the outer membrane, and target alteration, bacteria can become resistant to antibiotic therapy. The conventional method of creating new ant...

Nanoscale Scanning Thermal Microscopy using Improved Thermocouple Probes

JianlingL@tla.arizona.edu — Mon, 24 Nov 2025 14:43:16 GMT

This technology is a scanning thermal microscope device. It utilizes a thermocouple with a sharp tip on its center fabricated from a cross-junction of coated and uncoated thin films and is suspended on a nanowire device. Radiation heat received at the tip is converted into a Seeback voltage signal for thermoelectric temperature sensing. This device can operate without making physical contact with the object being scanned, enabling minimally invasive sensing, as well as with minimal direct contact between the tip and the sample. It delivers exceptionally high temperature sesnsing, offering two ...

AHPND Detection using Monoclonal Antibodies (mAbs)

JianlingL@tla.arizona.edu — Mon, 24 Nov 2025 09:02:17 GMT

Monoclonal antibodies (mAbs) with strong and specific immunoreactivity have been developed to improve the detection of acute hepatopancreatic necrosis disease (AHPND) in marine shrimp. This involves cloning and expressing recombinant PirA and PirB protein using a bacterial expression system and developing mAbs against those proteins. These monoclonal antibodies could be used for developing point-of-care diagnostics such as a lateral flow immunoassay strip in the future for detecting AHPND in shrimp aquaculture. Background: Acute hepatopancreatic necrosis disease (AHPND) is a...

Isolation of Protein Biomarkers from Saliva as a Technology to Assess and Monitor Cardiac Infarction

JianlingL@tla.arizona.edu — Mon, 24 Nov 2025 09:00:44 GMT

This technology introduces a novel separation method designed to isolate small protein biomarkers directly from saliva, enabling a rapid and non-invasive diagnostic approach for cardiac infarction. The system employs a hybrid chromatographic matrix that selectively rejects large proteins while allowing smaller biomarkers to interact with affinity sites and be effectively recovered. This streamlined process provides the foundation for saliva-based test kits that can support early detection and monitoring of heart damage and other diseases. The innovation not only broadens access to simple diagn...

Novel Mechanism-Based Therapy for Aortic Stiffening and Related Cardiovascular and Cerebrovascular Disorders

JianlingL@tla.arizona.edu — Mon, 24 Nov 2025 08:58:58 GMT

This invention involves a novel mechanism-based therapy by using a small molecule compound to reduce aging and hypertensive aortic stiffening, subsequently improve blood pressure (BP) control in resistant hypertension patients and prevent or reverse pathologies of vascular cognitive impairment and dementia (VCID) and Alzheimer’s Disease (AD). This approach works by inhibiting pro-stiffness signaling pathway to reduce aortic stiffness, disrupting the root cycle of hypertension. In addition, this mechanism mitigates cerebrovascular stiffening, cerebral hypoperfusion, and blood&ndash...

Repurposing the FDA-Approved Antibody to Treat Aortic Stiffening and Resistant Hypertension

JianlingL@tla.arizona.edu — Mon, 24 Nov 2025 08:58:36 GMT

This innovation repurposes an FDA-approved antibody to treat and prevent aortic stiffening and resistant hypertension (RH). This mechanism-based therapeutic, inhibits receptor mediated inflammatory and pro-stiffness signaling to reduce aortic stiffness and improve blood pressure control, ultimately breaking the root cycle of hypertension. Background: Hypertension is the leading cause of cardiovascular disease (CVD) and premature mortality, with prevalence increasing with age. Despite the availability of multiple medications, more than half of patients’ blood pressure (BP) remains ...

Ultra Black and Ultra White Coating on Different Sides of a Wind Turbine Blade to have Additional Energy from Solar

JianlingL@tla.arizona.edu — Thu, 13 Nov 2025 09:03:39 GMT

This invention aims to improve the efficiency and power output of wind turbines using additional energy from sunlight. The pressure side of each wind turbine blade is coated ultra black, and the suction side of each wind turbine blade is coated ultra white. When sunlight shines on the turbine, these coatings cause the light to contribute to the rotational energy of the turbine, increasing the turbine’s power output without altering turbine structure. Background: Renewable energy sources are crucial in working towards a more sustainable, environmentally conscious future. Wind...

Interface Profilometry with Third Harmonic Generation Microscopy

JianlingL@tla.arizona.edu — Mon, 10 Nov 2025 08:28:50 GMT

This invention describes a method of third harmonic-generation (THG) multiphoton microscopy for interface profilometry with depth resolution at the nanometer scale. While the axial resolution of the system is on the scale of micrometers, this invention can precisely define the peak of a THG depth response curve, or how intensity varies as a function of depth within a sample, at each point on the surface of the material it is imaging. Background: When applied to interface profilometry, third harmonic-generation (THG) microscopy offers a non-invasive way to measure and map interface...

Entanglement Distribution Over Atmospheric Turbulence Channels Enabled by Adaptive Optics

JianlingL@tla.arizona.edu — Tue, 04 Nov 2025 13:05:10 GMT

This innovation is a system and method for using free-space optical (FSO) links to distribute entanglement and use adaptive optics to deal with the effects of atmospheric turbulence. To generate entangled photons, the system uses mature telecommunications devices like a C-band tunable laser, periodically poled Lithium Niobate (PPLN) waveguides, and wavelength division multiplexers (WDM). Background: The markets for global communication systems, quantum computing, and adaptive optics are projected to experience significant growth, with CAGRs ranging from 11.5% to 31.2% during the f...

Low Probability to Intercept and Covert Communications over Atmospheric Turbulent Channels

JianlingL@tla.arizona.edu — Tue, 04 Nov 2025 09:02:08 GMT

This technology uses applied digital modulation and a thermal source signal to communicate though turbulent free-space optical. It also adds noise in select signal ranges to enable covert communication with lower probability of interception. Background: This technology increases the security in free-space optical transmission and reduces the probability of interception of the technology. This technology is applicable to various defense applications including radars, communication in contested environment, hypersonic communications, to mention few. Applications: Military ...

Novel Multi-Dimensional Mode-Hopping For Secure/Covert Free-Space Optical Communications

JianlingL@tla.arizona.edu — Mon, 03 Nov 2025 10:31:30 GMT

This invention describes a free-space optical communications architecture that enables robust and high-speed data links while maintaining security and strengthening resistance to eavesdropping. The technology utilizes mode-hopping through spectral, spatial, and temporal modes of a light beam while maintaining high bandwidth and multi-user operation of the optical link. Background: The popularity of free-space optical communication links has grown significantly over the past two decades, driven by the demand for faster and more secure communication technologies. Free-space optical commun...

Microbial Inocula, and the Design Thereof, that Improve Desired Traits of Field-Grown Sorghum

JianlingL@tla.arizona.edu — Mon, 27 Oct 2025 12:51:30 GMT

This innovation introduces microbial inocula that have been identified and tested for their ability to improve the performance of sorghum under field conditions. A structured workflow was developed to screen microbes naturally associated with sorghum plants, focusing on those linked to high-performing varieties. Specific microbial strains were isolated and selected that, when applied to sorghum seeds in powder or liquid formulations, enhanced measurable traits including total plant biomass, grain yield, and nutritional quality. Unlike approaches limited to greenhouse settings, this approach ha...

Modulation of Zinc and Other Desirable Micronutrients in Leafy Greens via Plant Microbiomes

JianlingL@tla.arizona.edu — Mon, 27 Oct 2025 12:45:15 GMT

This innovation introduces a new way to improve the nutritional quality of leafy greens through the use of naturally beneficial microbes. Research has shown that certain microbial strains associated with lettuce and related crops can significantly increase zinc levels in leaves, while also contributing to broader improvements in micronutrient profiles. Because the approach works with the plant’s own microbial community, it avoids the complexity and cost of genetic modification or heavy chemical inputs. The result is leafy greens that retain their flavor, texture, and consumer appeal whil...

Entanglement Assisted LPI and Covert Communications with SLM-based Beam Steering over Turbulent Optical Channels

JianlingL@tla.arizona.edu — Tue, 21 Oct 2025 15:11:14 GMT

This invention enables high-speed covert optical communication using entanglement-assisted transmission and spatial light modulators (SLM) for beam steering. This technology achieves better performance over turbulence than classical systems without requiring phase conjugation. Background: Covert optical communication technologies are becoming more heavily researched because of the growing need for secure and undetectable information transfer. Traditional communication systems emit detectable signals that may reveal the location of a transmitter. Optical methods of communication lo...

Cotton Microbiome Associated with Yield Uplift Under Drought Conditions

JianlingL@tla.arizona.edu — Mon, 20 Oct 2025 09:47:08 GMT

This invention includes specific microbes and an approach to the selection of those microbes involved with microbial taxa and microbial panels for producing desirable traits in world’s most important fiber crop, cotton. Researchers at University of Arizona found links between the plasticity of root-associated microbial communities and the plant performance. The findings led to development of a method to enhance drought resistance in cotton plants and improve key yield metrics such as boll weight and lint index in water-scarce conditions, making it essential for sustaining productivity in...

Real-Time Hemoglobin-Based Blood Loss Estimation System Using Disposable Reagent Cartridges

JianlingL@tla.arizona.edu — Mon, 20 Oct 2025 09:41:36 GMT

This invention relates to a novel, real-time blood loss quantification device for use in surgical and obstetric settings. This system estimates blood volume absorbed by surgical gauze or sponges by extracting hemoglobin into a fixed-volume reagent, then quantifying absorbance using optical detection methods. This solution improves accuracy over gravimetric and camera-based blood measurement methods and can be used in clinical, low-resource, and emergency settings. Background: In contrast to vital signs, blood loss is not automatically and continually tracked. Currently, the standa...

A Precision Anti-Infective for Enterococcus sp Eradication as well as Selective Decontamination

JianlingL@tla.arizona.edu — Mon, 20 Oct 2025 09:40:35 GMT

This innovation is a water-soluble nanocarrier that can precisely and quickly eradicate the healthcare-associated pathogen enterococci. The carrier can complex with oligonucleotides that can bind to bacterial mRNA, preventing translation and inhibiting bacterial functions of enterococci. It is also non-toxic to both human tissue and bacteria and may be used as a selective gastrointestinal tract decontaminant. Background: Enterococci are Gram-positive anaerobic bacteria commonly found in the gastrointestinal tracts of humans and animals but also present in environmental sources such as s...

Method and System for the Acquisition and Tracking of Free-Space Optical Communications Systems

JianlingL@tla.arizona.edu — Mon, 20 Oct 2025 09:39:45 GMT

This technology is a method and system to improve the speed of free-space optical communications. The technology uses a novel beam scanning technique to reduce the time needed for two optical communications terminals (OCTs) to locate each other and establish communications in linear time. This enables time-synchronized optical communications with minimal feedback as quickly as possible. The system can quickly reacquire broken links and can track a target OCT while a link is established. Background: Free-space optical communications systems use the propagation of light through a free spa...

Optogenetically Photosensitizable Self-Terminating Agrobacterium Tumefaciens

JianlingL@tla.arizona.edu — Tue, 14 Oct 2025 09:38:27 GMT

This invention aims to use optogenetic photosensitizers as genetically encoded microbial agents in order to develop strains of Agrobacterium tumefaciens that self-terminate with light exposure for use in plant transformation. This method increases the transformation efficiency of agriculturally relevant crop plants while reducing the cost of using antibiotics. Background: Agrobacterium tumefaciens serves as a natural pathway for gene transfer into plant cells. This process is a significant aspect of genetic engineering, allowing for the development of crops with improved traits li...

Technique for Measuring Particles with a Light Sheet Microscope

JianlingL@tla.arizona.edu — Tue, 14 Oct 2025 09:37:42 GMT

This invention is a companion device to the portable, field-deployable light sheet microscope device developed for detecting airborne particle morphology (UA26-002). This device has an improved, simplified design with an alternate optical configuration for imaging airborne particles as they pass through an air column. Background: Airborne particle characterization is an essential process in environmental science, industrial monitoring, and public health, aimed at analyzing particles suspended in the air to determine their size, shape, composition, and origin. This information is u...

Plasma-Based Emission/Pollution Control System

JianlingL@tla.arizona.edu — Tue, 14 Oct 2025 09:37:03 GMT

This technology uses cold plasma to break down pollutant chemicals as they are emitted, converting them into benign compounds. The cold plasma uses high-voltage electrical discharge to create ionized gas that interacts with pollutants in turbine exhaust. It breaks down nitrous oxides into nitrogen and oxygen or converts it into nitric acid. It oxidizes volatile organic compounds and formaldehyde into water vapor and carbon dioxide. The cold plasma can be incorporated into the exhaust ducting or stack of a power plant, turbine, or other pollution-emitting facility. Background: Turb...

Light Sheet Microscopy for Airborne Particle Morphology Characterization

JianlingL@tla.arizona.edu — Tue, 14 Oct 2025 09:36:13 GMT

This invention describes a portable, field-deployable light sheet microscope device that is optimized for detecting airborne particle morphology. This invention has the capability of real-time simultaneous characterization of airborne particles based on morphology, as well as abundance and size. Background: Airborne particle characterization is an essential process in environmental science, industrial monitoring, and public health, aimed at analyzing particles suspended in the air to determine their size, shape, composition, and origin. This information is used to assess air quality, id...

Automated System for Cognitive Testing and Psychological Enrichment in Dogs

JianlingL@tla.arizona.edu — Fri, 10 Oct 2025 10:37:01 GMT

This invention introduces a first-of-its-kind mobile touchscreen system designed specifically for dogs, combining cognitive testing with psychological enrichment. The system uses a transparent touch-responsive interface that dogs interact with using their noses. Images or tasks are displayed on a monitor, and when the dog selects the correct option, an integrated mechanical feeder dispenses a reward. Housed in a portable enclosure with wheels and handles, the system is easy to transport and adaptable to a variety of settings, from research labs to dog daycares and private homes. By merging fun...

Biofilm for Space

JianlingL@tla.arizona.edu — Thu, 09 Oct 2025 11:17:22 GMT

This technology is a microbial biofilm designed for survival and functionality in space environments made from a carefully selected combination of extremophiles, which are microorganisms, bacteria, and microbes capable of living in extreme conditions. Each extremophile has distinct capabilities that work together for oxygen production, radiation protection, extreme cold tolerance, and nitrogen for plant growth. Unlike single-species systems or synthetic modules, this living biofilm can self-repair, adapt to environmental changes, and provide multiple life-support benefits without constant resu...

RO - DBD Plasma Water Purifying and Desalination System

JianlingL@tla.arizona.edu — Thu, 09 Oct 2025 11:16:47 GMT

This technology is a water purification and desalination system that uses cold plasma in combination with reverse osmosis to target pollutants that cannot be removed by reverse osmosis alone. The approach is highly effective, with the cold plasma on its own having a microbial kill rate greater than 99.999%. This system can reduce Biochemical Oxygen Demand and Chemical Oxygen Demand, crucial indicators used to measure the levels of organic and inorganic pollution in water, by 30-70% while achieving desalination. Background: Desalination systems are a type of water treatment system focuse...

The Use of Cold Plasma to Facilitate CRISPR

JianlingL@tla.arizona.edu — Thu, 09 Oct 2025 11:15:56 GMT

This technology is a compact, automated cold plasma generator engineered to enable safe and efficient delivery of CRISPR-Cas9 into cells without chemical reagents. Through the use of cold plasma, cell membranes are transiently permeabilized, creating a controlled pathway for the entry of gene-editing components. This approach directly addresses critical barriers to the adoption of CRISPR by providing a delivery mechanism that is less invasive, more predictable, and broadly compatible with diverse cell types. This technology establishes a new standard for integrating cold plasma methods into ge...

Lasmiditan as a Treatment for Organ Transplant Rejection

JianlingL@tla.arizona.edu — Thu, 02 Oct 2025 11:17:28 GMT

Lasmiditan is a drug currently used to treat migraines. However, University of Arizona researchers discovered that Lasmiditan induces mitochondrial biogenesis in mouse kidneys and restores renal function to mice subjected to kidney injury. Mitochondria have been identified as important therapeutic targets in the aftermath of organ transplantation. This indicates that Lasmiditan could be repurposed to treat patients suffering from organ transplant rejection. Background: Organ transplant rejection occurs when, after an organ transplant, the immune system recognizes the new organ as ...

Vortex-Flow-Induced Microparticle Concentration as an Effective Approach to Remove Microplastics and Other Particles from Contaminated Water

JianlingL@tla.arizona.edu — Wed, 01 Oct 2025 10:49:23 GMT

This technology is a physical method for removing microplastics from water using acoustic waves to generate vortices in a flow of water through a pipe or chamber to trap microplastics and other contaminant particles, including sub-micron particles which will be focused at the vortices’ centers. Captured particles can then be removed through sedimentation techniques or by using a fine outlet pipe positioned at the vortex center within the water conduit. Ultimately, this technology improves particle concentration using an acoustic vortex for enhanced manipulation of ultra-small particles t...

Frequency-Locked Optical Microresonator System for Trace Detection of Mustard Gas

JianlingL@tla.arizona.edu — Tue, 30 Sep 2025 10:35:32 GMT

This invention is an optical sensing system for trace detection of mustard gas. It is a method of detecting small quantities of gases (such as mustard gas) using the Frequency-Locked Optical Whispering Evanescent Resonator (FLOWER) technique. Background: Optical microresonators are photonic devices that confine light in tiny volumes with very high-quality factors, enhancing light-matter interactions. By sustaining whispering-gallery modes, they can detect subtle changes in refractive index, absorption, or scattering caused by nearby molecules. This makes them powerful tools for ch...

Novel Nonalcoholic Beer Formula and Process

JianlingL@tla.arizona.edu — Mon, 29 Sep 2025 11:51:55 GMT

This is an innovative and efficient method to formulate nonalcoholic beer using a step-mashing process. It is designed to limit the production of fermentable maltose in a two-step process using variable temperatures. This method allows the use of lower levels of malt while still producing a desirable full-flavor taste, texture, and perception of body and fullness of traditionally brewed beer by carefully managing the action of natural enzymes in malted wheat and barley through a structured program of temperature, pH and volume change during the mashing process coupled with the use of selected ...

Optogenetic ROS-Initiated Systemic Stress-Acclimating Programmable Plants (Arabidopsis Prototype)

JianlingL@tla.arizona.edu — Mon, 29 Sep 2025 09:30:33 GMT

This technology introduces optogenetic tools that enable precise control of reactive oxygen species (ROS) production in plants through targeted light exposure. These genetically encoded photosensitizers can be activated to generate specific types of ROS in subcellular compartments, allowing researchers to study how plants initiate and transmit stress signals over long distances. The system makes it possible to trigger and visualize systemic stress responses, such as drought tolerance, from localized stimulation. Designed to be used in model plants like Arabidopsis thaliana, the technology hold...

Handheld Electrofishing Removal Device

JianlingL@tla.arizona.edu — Mon, 29 Sep 2025 09:29:41 GMT

This technology is an electrofishing device designed for the removal of invasive fish species from streams and rivers. The device can emit a specific amount of current to create an electric field in the body of water which causes involuntary muscle spasms in nearby fish, drawing the fish towards the device. This technique was demonstrated to be capable of gathering 90% of the fish in the device’s vicinity. Once the fish are gathered, they can be sorted through to find and remove any invasive fish species. This technology provides a simple, low-cost, effective method for reducing invasive...

Interferometric Focal Planes

JianlingL@tla.arizona.edu — Mon, 29 Sep 2025 09:28:35 GMT

This technology introduces a new kind of camera sensor in which each pixel functions as a tiny interferometer, instead of a standard light detector. This allows the sensor to capture not only the brightness of a scene but also additional information about the light’s spatial coherence. By leveraging arrays of integrated interferometers, the system captures a richer dataset that enables more precise image reconstructions and feature detection, even when traditional resolution limits would normally apply. This approach enhances how scenes are captured and interpreted, particularly when fin...

Spectrometer-Free Biosensing Using Photonic Diffractive Computing for Direct Optical Readout

JianlingL@tla.arizona.edu — Fri, 26 Sep 2025 10:47:22 GMT

This invention introduces a photonic diffractive computing biosensing system that converts analyte-induced spectral changes directly into distinct spatial intensity patterns, enabling classification or concentration measurement without spectral reconstruction. An element in the system produces a resonance shift after detection, which produces a diffraction pattern on a detector. The detector readout directly encodes the analyte presence in the system. Background: Many existing optical biosensing methods such as surface plasmon resonance (SPR) or surface plasmon polaritons (SPPs) d...

Suspended Photonic Membrane Sensor with Resonance Modulation via Substrate-Proximal Coupling

JianlingL@tla.arizona.edu — Fri, 26 Sep 2025 10:44:11 GMT

This invention describes a novel photonic sensor based on a suspended membrane and a substrate that supports high-Q optical resonances sensitive to nanometer-scale membrane deflections. The technology exploits mechanically induced modulation of optical resonance conditions (such as guided-mode resonance, bound states in the continuum, and high contrast gratings) by controlling the vertical separation between a membrane and substrate. This allows for accurate alignment of components used in manufacturing semiconductor devices without relying on on-chip photodetectors. Background: In rece...

Secretory Acid Sphingomyelinase Activity as a Diagnostic Marker in Colorectal Cancer

JianlingL@tla.arizona.edu — Mon, 22 Sep 2025 10:01:35 GMT

This invention utilizes the activity of secretory acid sphingomyelinase (S-SMase) in patient serum as a biomarker for the early or enhanced detection of colorectal neoplasia, including colorectal cancer (CRC). Background: Colorectal cancer (CRC) is one of the most common cancers worldwide, ranking third in incidence and second in cancer-related deaths globally. While early detection significantly improves survival rates, many individuals do not undergo routine screening, reducing the effectiveness of treatment. CRC often develops slowly from precancerous polyps, making it highly prevent...

Two-Pumps-Based Degenerate Entanglement Assisted Communication with SLM-Based Beam Pointing

JianlingL@tla.arizona.edu — Mon, 22 Sep 2025 10:00:36 GMT

This technology is an entanglement assisted (EA) communications system that employs two pump lasers in order to more easily satisfy quasi-phase matching conditions. Rather than performing optical phase-conjugation (OPC) on signal photons, this technology transmits unmodulated idler photons alongside modulated signal photons without the use of OPC. This decreases the impact of atmospheric effects such as scattering, diffraction, absorption, and turbulence in free-space optical (FSO) applications. SLM-based beam steering is used to achieve the FSO link. Ultimately, this technology achieves a str...

Covert Free-Space Optical Communications with SLM-Based Beam Steering

JianlingL@tla.arizona.edu — Mon, 22 Sep 2025 09:59:43 GMT

This is a system for secure low probability of detection communications across a free-space optical (FSO) channel. The system utilizes an LED-based source which transmits signals with distributions that match the distribution of the background solar radiation, which hides the signals. The transmitted signals are modulated according to a phase-shift keying (PSK) which is encoded and transmitted to allow for decoding on the receiver end. The free-space optical link is established using a spatial light modulator (SLM)-based beam steering approach. This low-cost approach achieves reliable covert c...

Analog Photonic Second-Derivative Filter for Enhanced Shadowgraphy Imaging

JianlingL@tla.arizona.edu — Mon, 22 Sep 2025 09:57:58 GMT

This invention is a method to augment conventional shadowgraphy using an analog photonic pre-processor to deliver high-sensitivity imaging of refractive-index gradients in transparent media. The system operates in real-time, has enhanced sensitivity, and is compact, making it ideal for mobile and field-deployable sensors. It can retrofit existing shadowgraphs or be integrated into new systems designed for optical flow visualization, fluid-dynamics imaging, and analog photonic computing. Background: Shadowgraphy is an optical method for visualizing fluid flows, thermal plumes, and shock ...

Methods to Differentiate Naive and Pluripotent Stem Cell-Derived B Cells into Plasma Cells

JianlingL@tla.arizona.edu — Mon, 22 Sep 2025 09:56:31 GMT

This invention is a method to generate plasma cells from primary and stem cell-derived B cells and includes characterization of cellular intermediates during the maturation process. Background: The inefficient generation of plasma cells from primary naïve B cells is due to a combination of intrinsic cellular limitations and external signaling requirements. Human pluripotent stem cells can serve as a scalable source of therapeutic cell types, such as antibody-secreting plasma cells, by providing a limitless, adaptable supply of cells that may be guided through a multi-phase differen...

Lipid-Based Diagnostic for Minimally-Invasive Screening and Early Detection of Gynecologic Cancer

JianlingL@tla.arizona.edu — Mon, 22 Sep 2025 09:53:18 GMT

This invention is a non-invasive diagnostic for the screening and early detection of gynecologic cancers, including endometrial, cervical, and ovarian cancer, based on a lipid panel. It analyzes cervicovaginal lavages for key biomarkers that could ultimately be used a screening technology as a part of a well-woman exam to assess the risk of gynecologic cancers. Background: Cervical cancer is the fourth most common cancer in women, globally. Endometrial cancer is the sixth most common cancer in women, globally. Current first-line definitive diagnostic methods for endometrial cancer...

SHIP: A Smart Non Wearable Device to Track Sleep Hygiene and Diagnose Sleep Disorders

JianlingL@tla.arizona.edu — Fri, 19 Sep 2025 10:54:47 GMT

The Sleep Hygiene Innovation Pillow (SHIP) is a non-wearable smart system that transforms a traditional pillow into a health monitoring device. SHIP uses sensors to continuously record head movement patterns during sleep, then processes that data through proprietary signal analysis and a machine learning algorithm that distinguishes between normal physiological motion and patterns associated with specific sleep disorders. The system outputs a proprietary Sleep Quality Index that translates the data into an accessible metric, allowing for objective evaluation of sleep hygiene. The integration o...

Pioneering Cell-Based Solutions for Vascular Aging

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:59:52 GMT

This invention is a mechanism-based cell therapy for treating aortic stiffening, particularly in cases of old hypertension patients that do not respond to current treatments. It is also intended to help prevent cardiovascular disease and promote healthy aging in older populations. Background: Aortic stiffening is a critical age-related risk factor that worsens hypertension and drives cardiovascular and neurodegenerative disease, yet no therapies directly target it, creating a major barrier to managing hypertension in older patients, leading to severe complications and premature mortalit...

Bottom-Up Low-Temperature Synthesis of Graphene Interconnects for GAAFETs

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:48:09 GMT

This invention introduces a method for creating ultra-thin, highly conductive carbon-based wiring, called graphene interconnects, on metal surfaces at low temperatures. These interconnects are intended to replace traditional copper wiring used in advanced semiconductor devices, particularly those based on Gate-All-Around Field-Effect Transistors (GAAFETs). As chip features become smaller, conventional copper interconnects suffer from rising resistance and reliability issues due to size constraints and material limitations. This technology forms graphene structures using a bottom-up synthesis p...

Development of Single-Crystalline 2D Gate Dielectrics for GAAFET Technologies

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:48:01 GMT

This invention introduces a new class of materials designed to improve how next-generation chips manage electrical signals at extremely small scales, particularly those based on Gate-All Around Field-Effect Transistors (GAAFETs). These single-crystalline 2D dielectrics offer high dielectric strength and stability, helping to reduce power loss and signal interference in advanced transistor designs. Examples of suitable dielectric materials for use in this invention include, but are not limited to, lanthanum oxide compounds (LaOX, where X is a halogen), bismuth-based layered oxides (Bi2XO5, wher...

Altering Legume Phenotypes with Seedborne Microbes for Nutrition and Resilience of Pulses as Climate-Proof Crops

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:37:36 GMT

This technology leverages seed-associated bacterial endophytes to enhance the traits of tepary beans and other legumes. The inventors developed a novel workflow to isolate and screen beneficial microbes from seeds, allowing for predictive assessment of plant growth benefits such as phosphate solubilization, ammonium production, and siderophore activity. Two promising endophytes were identified and tested in field trials, where they improved seedling traits without disrupting the plant’s microbiome. These microbial inoculants can be used to enhance plant traits such as stress tolerance, g...

CD64+ AND CD14+ Cell Replacement Therapy for Wound Healing

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:33:31 GMT

This technology is a cell-based therapy involving an administered dose of cells expressing both CD64+ and CD14+ ligands. It is designed to promote healing in diabetic patients, with potential to reduce inflammation and support tissue regeneration. The cells can be observed in tissue, blood, and bone marrow, allowing for broader variety in addressing systemic diabetic complications. Background: Chronic inflammation is a hallmark of diabetes, driven by factors such as insulin resistance, elevated blood glucose levels, and the accumulation of advanced glycation end products (AGEs). In diab...

Offline Eye Gaze-Based Visual Field Testing System

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:32:10 GMT

This technology introduces a portable and affordable way to perform visual field assessment using only a standard webcam and machine learning software. Unlike conventional systems that rely on costly specialized equipment and require constant supervision, this approach tracks eye movements in response to simple on-screen visual stimuli. The software then analyzes gaze patterns to infer potential visual impairments. By removing the need for internet connectivity, external devices, or technician oversight, the system provides a scalable and accessible solution that can be deployed in clinics, te...

Biomarker for the Classification of Melanocytic Neoplasms

JianlingL@tla.arizona.edu — Mon, 15 Sep 2025 09:29:47 GMT

This invention relates to potential transcriptomic biomarkers using gene- or protein-level expression of individual or a combination of the 23 genes/proteins to accurately differentiate between low-risk, benign from high-risk, malignant melanocytic neoplasms. This approach aims to improve the accuracy of melanoma diagnosis and reduce diagnostic uncertainty. Background: A melanocytic neoplasm refers to a growth or tumor that originates from melanocytes and can be classified as benign (like melanocytic nevi or moles) or malignant (like melanoma, the deadliest form of skin cancer). Many me...

Visualizing the Impact of Changes in Microservices

JianlingL@tla.arizona.edu — Mon, 08 Sep 2025 10:12:59 GMT

This technology is a Software Architecture Visualization and Analysis Tool (SAVAT) designed to assist developers in understanding the impacts and ripple effects of changes in microservice systems. This SAVAT generates visualizations of microservice interactions in the system from service and domain architectural views, integrating context maps, service dependency graphs, and inter-microservice call graphs. Next, change impact analysis is performed on the context maps and inter-microservice call graphs to provide further insights into potentially undesired effects of changes and to compare diff...

Tunable Communication Bandwidth Filter

JianlingL@tla.arizona.edu — Mon, 08 Sep 2025 10:06:20 GMT

The Tunable Communication Bandwidth Filter is a highly efficient electro-optically driven filter designed to dynamically adjust to specific frequencies within the full communication bandwidth of 1270-1620 nm. Unlike traditional filters, which may be static or slower in response, this innovation allows for rapid tuning, making it ideal for high-speed fiber-optic and electro-optic communication systems. The key advantage is its ability to optimize data transmission while minimizing energy consumption, a critical factor for large-scale data centers. Background: Modern data centers rely on ...

Diagnostic for Prostate Cancer Treatment Outcomes

JianlingL@tla.arizona.edu — Mon, 08 Sep 2025 10:04:43 GMT

This technology offers a novel diagnostic tool that predicts prostate cancer treatment outcomes using a chromosomal instability signature based on nine genes. Developed through a multi-omics approach, this signature was identified in prostate epithelial cells experiencing transient centrosome loss—an event known to drive chromosomal instability and aggressive cancer behavior. The gene signature has been validated in multiple patient datasets and is strongly associated with poor clinical outcomes, including higher Gleason scores, increased tumor aggressiveness, and reduced survival. This ...

Method and System for Detecting Refractive Flow Disturbances Using Time-Resolved Angular Filtering

JianlingL@tla.arizona.edu — Thu, 04 Sep 2025 11:57:17 GMT

This technology is a method for detecting refractive index variations in transparent media through passive optical imaging without the need for structured backgrounds or active illumination. This method involves use of thin films to convert angular deflections of ambient light caused by refractive index gradients into measurable intensity modulations using angularly selective optical filters. The detection of refractive index variations has a wide range of applications, from the estimation of motion and maneuvering intent of planes and drones to the analysis of atmospheric turbulence. B...

Single-Shot Phase Gradient Separation Using 2D Anisotropic Metasurfaces for Zonal Phase Reconstruction

JianlingL@tla.arizona.edu — Thu, 04 Sep 2025 11:53:13 GMT

This invention is a compact, single-shot optical imaging technology that captures complete two-dimensional phase gradient information from transparent or weakly scattering samples in real time. By integrating a specially engineered metasurface into the imaging setup, the system separates and detects both horizontal and vertical phase gradient components simultaneously, something current systems cannot do without multiple images or moving parts. The ability to recover full phase data instantly from a single frame makes this technology well-suited for environments where speed, stability, and pr...

A Piezo-Actuated Optomechanical Magnetometer

JianlingL@tla.arizona.edu — Wed, 03 Sep 2025 13:43:47 GMT

This technology provides a highly sensitive, compact device designed for precise magnetic field measurements across a wide frequency range. By integrating photonic structures with magnetostrictive and piezoelectric thin films, the invention efficiently converts magnetic fields into detectable signals. One notable benefit is its adjustable piezoelectric actuation, allowing users to easily tune the device to optimal sensing conditions. This adaptability significantly improves accuracy, sensitivity, and reliability, making it ideal for applications requiring high precision in challenging environm...

TDP-43 In Vivo Mouse Model

JianlingL@tla.arizona.edu — Tue, 02 Sep 2025 10:23:26 GMT

This is an in vivo mouse model of TDP-43 proteinopathy that captures key features of human neurodegenerative disease, particularly Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). The model targets a disease-relevant disruption in TDP-43’s interaction with cytoplasmic translational machinery, causing a cascade of human-like TDP-43 proteinopathy in vivo. Importantly, although the genetic change is systemic, pathological and degenerative changes are confined to the central nervous system, revealing a novel observation about the CNS’s intrinsic suscept...

A Cellular Key Adaptation Aiding Seedling Survival in Nutrient-Limited and Drought Conditions

JianlingL@tla.arizona.edu — Tue, 02 Sep 2025 10:22:22 GMT

This invention describes a newly identified unicellular structure in Phaseolus vulgaris, referred to as the “hooked hair.” It features a unique pointed hook morphology and appears during early seedling development, prior to the emergence of root hairs or above-ground trichomes. Observed in the hypocotyl-radicle junction region below-ground, hooked hairs show phenotypic responses to phosphorus and nitrogen limitations, including quantifiable morphological changes in area, perimeter, and length. Gene-expression analysis revealed signatures related to nutrient transport, suberin biosy...

Modifying the Gastric Tumor Microenvironment with Tadalafil

JianlingL@tla.arizona.edu — Tue, 02 Sep 2025 10:19:01 GMT

This technology leverages phosphodiesterase 5 (PDE5) inhibitors—such as tadalafil and sildenafil—in combination with the standard of care to treat gastric adenocarcinomas (GAC). The use of PDE5 inhibitors has the potential to enhance immune response and treatment outcomes with a well-established safety profile. Background: Gastric adenocarcinoma (GAC) presents significant treatment challenges, with a 5-year survival rate near 18% despite advances combining chemotherapy, immune checkpoint inhibitors, and HER2-targeted therapies. There is a clear unmet need for precision-guide...

Liquid High Sulfur Content Resins for Commodity and Specialty Polymeric Materials

JianlingL@tla.arizona.edu — Tue, 02 Sep 2025 10:16:41 GMT

This technology enables the room-temperature synthesis of liquid sulfur-based resins with high sulfur content, offering a novel route to create low-cost, low-viscosity prepolymer materials. By incorporating reactive thiols into sulfur-styrene prepolymers, the resulting resins are readily compatible with a wide range of organic comonomers. These resins can undergo photopolymerization or thermal curing at ambient temperatures, making them ideal for applications like 3D printing and aerospace coatings. This innovation overcomes long-standing challenges with sulfur polymerization, including high-t...

System and Method for Predicting Rotorcraft Motion Using Flow-Field Imaging and Rotor State Inference

JianlingL@tla.arizona.edu — Mon, 25 Aug 2025 12:54:39 GMT

This invention is a method and system that uses flow-field imaging techniques to predict rotorcraft motion and rotor state interference. By extracting and analyzing the aerodynamic wake and flow structures generated by rotor systems in a computational framework, the system can estimate and forecast the trajectory and control state of rotorcraft. This has application in defense, aerospace, and autonomous surveillance for passive and predictive estimation of rotorcraft intent, enabling improved interception, classification, and traffic management. Background: Conventional rotorcraft track...

Apparatus and Method for Calcination and Capture of CO2 From a Bed of Reactant Particles, Powered by Focused Sunlight

JianlingL@tla.arizona.edu — Mon, 25 Aug 2025 12:53:14 GMT

This technology is a calcination apparatus and method powered by focused sunlight, optimized to enable the direct air capture (DAC) and calcination of carbon dioxide. The apparatus consists of a heating chamber with a rotating dish to evenly distribute and process a batch of solid reactant particles. Then, focused sunlight is directed into the chamber and is converted into heat while further shaking of the dish facilitates a faster transfer of heat throughout the full depth of the particle bed. When calcination is complete, the dish stops rotating and the particles flow downwards through a hol...

Topological Acoustics based Radio Frequency Surface Acoustic Wave Devices

JianlingL@tla.arizona.edu — Mon, 25 Aug 2025 12:31:37 GMT

This invention proposes a sound-acoustic wave (SAW) device that integrates topological acoustics and phase change materials to enable a new generation of reconfigurable SAW devices. The purpose of these devices is to enhance the high quality factor using the footprints of existing devices, but without sacrificing transmittivity. This invention integrates several technologies, including fabrication of SAW devices, laser-rewritable phase change materials, and acoustic superlattice/phononic crystals supporting topological waves that have not yet been reported for the development of devices with a...

Systems and Methods for Producing Reconfigurable Non-Volatile Acoustic Devices

JianlingL@tla.arizona.edu — Mon, 25 Aug 2025 12:29:44 GMT

This innovation introduces a new class of fully reconfigurable, non-volatile acoustic devices that utilize phase change materials (PCMs) to create tunable patterns for controlling acoustic wave propagation. Unlike traditional acoustic components, which are fixed in function due to static material properties, this technology enables endless reconfiguration of functionality within a single device without the need for continuous power input. Leveraging PCMs that switch between two solid phases with significantly different mechanical properties, these devices allow for persistent, reversible struc...

Method and System for Amplitude and Phase Modulation of Light Fields

JianlingL@tla.arizona.edu — Mon, 18 Aug 2025 09:48:53 GMT

This technology is a method designed to enable complex and/or high-discretization light field modulation in devices using a novel pixel interference technique. This method offers a way of improving the performance of a wide range of optical technologies, enabling phase-only modulators to project complex fields, and all modulators to modulate fields with higher levels of quantization. Background: There are a wide range of optical modulators such as Liquid Crystal Displays (LCDs), Digital Micromirror Devices (DMDs), Liquid Crystal on Silicon (LCoS) modulators, Phase Light Modulators...

Meissner Effect Memory Resistor (MEMR)

JianlingL@tla.arizona.edu — Mon, 18 Aug 2025 09:45:43 GMT

This invention consists of a Meissner Effect Transistor (MET) consisting of a superconducting bridge engineered to retain a memory of past currents or voltages through magnetic flux pinning. Due to its ability to retain knowledge of current, the Meissner Effect Memory Resistor (MEMR) can serve the role of a memory synapse in artificial neural networks to solve machine learning problems, matching or exceed the capabilities of the human brain. Background: Memristors are electronic components whose resistance changes based on the amount and direction of charge that has flowed through...

DHODH Inhibitors

JianlingL@tla.arizona.edu — Mon, 18 Aug 2025 09:43:53 GMT

This technology includes novel compounds that selectively inhibit fungal dihydroorotate dehydrogenase (DHODH), an essential enzyme in pyrimidine biosynthesis. These inhibitors are active against a range of fungal pathogens, including Cryptococcus neoformans and Candida auris, while sparing the human version of the enzyme. This selectivity reduces the risk of toxicity and offers a new approach to treating difficult fungal infections. Background: Fungal diseases require greater attention due to the limited number of antifungal drug classes and the increasing prevalence of drug resistance....

Enzyme Replacement Therapy in Niemann-Pick Disease

JianlingL@tla.arizona.edu — Thu, 14 Aug 2025 10:39:47 GMT

University of Arizona researchers have developed an acid sphingomyelinas knockout (aSMaseKO) mouse model as a proof-of-concept for using the mutant enzyme in enzyme replacement studies for Niemann-Pick disease (NPD). NPD is a rare, inherited disease that affects the body's ability to metabolize fat within cells. The inventors suggest that a mutant form of acid sphingomyelinas (aSMase) presents a novel approach for recombinant studies geared at restoring lysosomal aSMase (L-Smase) activity while avoiding the inflammatory response attributed to secretory aSMase (S-Smase) activity. Data demon...

AI-Enhanced Wearable Multi-Microphone Fetal Heart Rate Monitoring Belt with Maternal Heart Rate Differentiation

JianlingL@tla.arizona.edu — Wed, 13 Aug 2025 15:57:03 GMT

This invention is for a wearable belt encapsulating a fetal heartrate monitoring device (FHR). It employs a multi-microphone array for differentiation of maternal and feta heartbeats and utilizes data from real-time signal processing in conjunction with AI to achieve precise fetal monitoring. The device features wireless connectivity, transmitting real-time data to a smartphone application where users can visualize fetal heart rate trends, receive AI-based alerts, and sync data with cloud storage for remote physician access. This non-invasive, hands-free, and AI-enhanced monitoring solution of...

Lateral Flow Assay for sFlt1/PlGF Biomarker Detection in Preeclampsia Diagnosis

JianlingL@tla.arizona.edu — Wed, 13 Aug 2025 15:44:16 GMT

This technology is for a novel lateral flow strip (LFS) diagnostic assay for early diagnosis of preeclampsia in prenatal care. This point-of-care test aims to measure the soluble fms-like tyrosine kinase-1 (sFlt1) to placental growth factor (PlGF) ratio within the blood in order to determine preeclampsia risks in a timely manner. A mobile app assists with automated risk stratification and and remote clinical consultation. This rapid, cost-effective, point-of-care diagnostic can be used in home settings, rural areas, and in low-resource healthcare facilities without a laboratory. Background: &...

Passive Airflow Valve for Wind Load Reduction and Water Protection

JianlingL@tla.arizona.edu — Wed, 13 Aug 2025 14:15:55 GMT

This invention aims to improve the performance of umbrellas, tents, canopies, and other outdoor structures that must keep water out while withstanding a high wind load. The technology leverages multiple-aperture air valves, with various areas of flexibility, that seal when met with rain but open to allow air to flow in. By doing so, this decreases the wind load experienced by a structure while maintaining water protection. This reduces the overall stress a structure experiences, reducing occurrences like umbrella inversions. Furthermore, this technology could also be incorporated into wearable...

Smart Pessaries for Uterine Prolapse

JianlingL@tla.arizona.edu — Tue, 12 Aug 2025 15:27:24 GMT

The invention is a smart pessary device designed to provide non-surgical support for pelvic organ prolapse and related conditions. It is embedded with real-time biosensors that continuously monitor vaginal pH, temperature, and hydration levels. This device also features a self-adjusting shape to ensure optimal fit and offers pelvic floor stimulation to support muscle strength and function. Additionally, it sends timely notifications via a mobile app to remind users to remove, clean, and replace the device, while providing real-time alerts to both users and healthcare providers to monitor for s...

Turbo-Annihilation of Hook Errors in Stabilizer Measurement Circuits

JianlingL@tla.arizona.edu — Mon, 11 Aug 2025 10:04:00 GMT

This technology is a quantum error correction method consisting of a scalable algorithm for decoding circuit-level noise in quantum circuits. The algorithm models the data errors caused by hook faults in quantum circuits, using a memory channel modeling system. Then, a trellis-based decoding algorithm is used to achieve high-performing, efficient and scalable correction of circuit-level quantum error. Background: Traditional circuit-level decoding attempts to estimate the precise location of faults by constructing an extended Tanner graph that includes every possible source of noi...

A Novel Biomimetic Method of Biosensor and Electronics Adhesion in the Musculoskeletal System

JianlingL@tla.arizona.edu — Mon, 11 Aug 2025 10:03:02 GMT

This technology introduces a novel, biomimetic method securely attaching biosensors and bioelectronics to musculoskeletal tissues. By mimicking natural adhesive processes found in marine organisms, it enables durable, long-term bonding between sensors coated with Parylene C and various tissues such as bone, cartilage, muscle, and tendon, and a stable connection over time in the body’s dynamic environments. The result is improved performance of implantable devices without the degradation seen in traditional adhesives. This enhanced biomimetic adhesion method offers new possibilities for d...

High-Sensitivity Acoustic Sensing via Free-Space Coupled Microtoroid Resonators

JianlingL@tla.arizona.edu — Mon, 11 Aug 2025 10:00:48 GMT

This technology introduces a high-sensitivity acoustic sensing system based on a microtoroid resonator paired with a free-space optical coupling setup. Sound waves in the environment create tiny vibrations that shift the resonator’s frequency, allowing even subtle acoustic signals to be picked up with great precision. Unlike traditional sensor setups, this approach uses free-space optics, which simplifies system alignment and boosts resistance to environmental interference. The system has been successfully tested for detecting speech, with recorded demonstrations showing clear signal re...

Δ-cps1 Mutant as a Target to Detect Coccidioides Immunity

JianlingL@tla.arizona.edu — Mon, 11 Aug 2025 09:59:42 GMT

This technology is a diagnostic platform that utilizes Flow Link Immunosorbent Assay (FLISA) and Δ-cps1, a live attenuated strain of Coccidioides posadasii, to detect if an individual (including animals) has mounted a response to coccidioidomycosis either from infection or vaccination. Δ-cps1 can be used as a stimulus to detect cellular (T-cell driven) immunity to Coccidioides using flow cytometry intracellular cytokine staining (ICS) and detect humoral (cell/antibody driven) immunity using the FLISA test. By assessing both cellular and antibody-based immune activity, this test off...

Preparation of Apomorphine and its Analogs for Neurodegenerative Disease Applications

JianlingL@tla.arizona.edu — Mon, 11 Aug 2025 09:58:41 GMT

This invention involves methods of apomorphine synthesis from different starting blocks to facilitate more robust drug development campaigns by enabling chemical substitutions at unexplored locations. It includes total synthesis of apomorphine from readily available fragments and whose synthetic design approach centers around being maximally amenable to diverted total syntheses (DTS) campaigns to enable access to aporphine analogs that were previously hard to access. The approach opens up significant opportunities for more targeted drug development to treat neurodegenerative diseases, such as ...

High Secret-Key Rate Atmospheric Turbulence-Based Cryptosystems

JianlingL@tla.arizona.edu — Fri, 08 Aug 2025 09:37:28 GMT

This technology is a cryptosystem that utilizes atmospheric turbulence over a communication channel as a source of randomness. The cryptosystem utilizes bidirectional modulators at both ends of the communication to remodulate received signals. This method enables key generation and the generation of random sequences to occur independent of the long coherence times of the atmospheric turbulent channel, allowing for secret key rates comparable to data rates achieved in state-of-the-art optical communication methods, while maintaining a level of security comparable to that of quantum key distribu...

Backsurface Treatment of Optical Substrates for Improved Thermal Conductivity and Dynamic Survival

JianlingL@tla.arizona.edu — Thu, 07 Aug 2025 15:05:46 GMT

This invention is an adhesive that is applied to the back of optical substrate mirrors such as the ones used in aerospace applications. The adhesive when applied, it provides acoustic dampening and uniform dissipation of heat, thus protecting the optical component from stress and heating. This is particularly innovative for aerospace applications where optical components require robustness against severe temperature gradients and mechanical vibrations. The adhesive’s unique composition allows for a significant enhancement in the thermal management of the mirrors and increased resiliency,...

Using Squeezed Light for Enhanced Change-Detection in a Laser Communication Channel

JianlingL@tla.arizona.edu — Thu, 07 Aug 2025 14:20:43 GMT

Invention: This invention describes how to augment a train of bright phase-modulated laser light pulses of a communications system by splitting squeezed light. This can be used to detect minuscule drops in connectivity and channel loss without affecting the communications rate. Connectivity drops in laser or fiber-optic communication systems can occur due to a range of factors, including deliberate intrusion attempts such as wiretapping, as well as more benign or environmental causes. A disturbance may be brief or subtle, but it often disrupts the precise balance of signal transmission, especi...

Method and System for Reducing Wind Speeds to Mitigate Wildfire Spread

JianlingL@tla.arizona.edu — Wed, 06 Aug 2025 11:16:34 GMT

This technology introduces a landscape-integrated system that slows down hazardous winds in wildfire-prone areas by strategically disrupting airflow using engineered structures. These modular obstacles, such as columns, ridges, or terrain-guided elements, are arranged based on fluid dynamics principles and terrain modeling to control and reduce wind speed and ember transport. By controlling localized wind behavior, this approach can help mitigate wildfire spread, especially in high-risk zones like canyon mouths and mountain passes. Unlike conventional firebreaks or uniform wind fences, this te...

XUV Photonic Integrated Circuits with Vacuum Guiding

JianlingL@tla.arizona.edu — Wed, 06 Aug 2025 11:16:17 GMT

This invention is a novel approach to developing photonic integrated circuits operating in extreme ultraviolet wavelength (XUV) range. This technology enables the fabrication of XUV components, including waveguides, photonic crystal cavities, or resonators while using vacuum as the guiding medium. Background: Currently, there is a critical challenge in XUV photonics concerned with substantial material absorption and loss at extreme ultraviolet wavelengths. Most materials exhibit a negative part of the refractive index which makes them unsuitable for traditional waveguides. Vacuum ...

Dynamically Controlled Pupil Steering Method for Enhanced Light Efficiency in Head-Mounted Displays

JianlingL@tla.arizona.edu — Mon, 04 Aug 2025 11:25:20 GMT

This is a programmable backlight display for head-mounted displays (HMDs) that dynamically steers light to the viewer’s pupil based on real-time eye tracking. This method reduces power consumption by illuminating only the necessary region corresponding to the pupil location while also improving brightness uniformity and efficiency. It also helps mitigate the vergence accommodation conflict, which occurs when the brain receives conflicting depth cues for visual focusing and can result in eye strain, headaches, blurred vision, dizziness or nausea. This invention offers a compact and power-...

Programmable Diffractive Photonic Computing Using Pixel-Level Post-Processing for Adaptive Data Classification

JianlingL@tla.arizona.edu — Mon, 04 Aug 2025 11:23:39 GMT

This invention provides a programmable diffractive photonic computing system that uses a single diffractive surface in combination with a Complementary Metal-Oxide-Semiconductor (CMOS) pixel array for data processing and classification. Unlike traditional systems requiring spatial light modulators or multiple diffractive planes, programmability is achieved through pixel-level post-processing. By selecting and operating on specific pixels in the detector array, the system adapts to varying tasks without modifying the diffractive surface. This innovation reduces power consumption and latency whi...

Polarization-Multiplexed Vortex Coronagraph Metasurface for Single-Shot Exoplanet Imaging

JianlingL@tla.arizona.edu — Mon, 04 Aug 2025 11:22:54 GMT

This invention is a metasurface-based optical element that enables high-contrast imaging of exoplanets in a single shot. By integrating both vortex phase modulation and polarization-dependent beam deflection into a single optical component, the technology simplifies the process of blocking out starlight to reveal nearby exoplanets. Traditional coronagraphs often require multiple optical elements or sequential imaging steps—this metasurface streamlines the system into one efficient device. The device enhances detection sensitivity through polarization-differential imaging, removing the n...

Fall Prevention System for Alzheimer’s Dementia, and Diabetes Using a Combination of Imaging, LiDAR, Machine Learning, and Auditory Feedback

JianlingL@tla.arizona.edu — Mon, 04 Aug 2025 10:57:47 GMT

This invention leverages personal information, including body weight, height, body shape, and bone density, to compute the user's center of gravity and spatial position in real-time. This innovative technology goes beyond conventional applications by providing instantaneous auditory feedback when the user's center of gravity indicates a potential fall. This proactive approach is particularly beneficial for individuals prone to balance issues, such as the elderly, people with certain medical conditions, or those recovering from injuries. Moreover, the technology extends its utility by a...

Method for Optimizing an Integrated Flight Control System using Reinforcement Meta-Learning

JianlingL@tla.arizona.edu — Wed, 30 Jul 2025 14:45:48 GMT

This technology is a method to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control system on a missile is the key element that enables the missile to hit the system performance requirements. Its main purpose is to force the missile to achieve the maneuvering commands that are input by the guidance system. The settings of the...

Profiles of Working Memory for Educational Research (POWER)

JianlingL@tla.arizona.edu — Mon, 28 Jul 2025 10:09:09 GMT

Profiles of Working Memory for Educational Research (POWER) is a game-based software that is used to assess working memory in school-aged children with limited language skills. Administered on a computer, the game-based environment uses a touchscreen-based assessment within a “pirate adventure” framework and also includes rewards and a virtual store. The software does not intend to improve working memory, only to provide assessment, and may be used by researchers and educators. Background: Working memory plays a vital role in our ability to concentrate, follow instructions, ...

Achieving Quantum-Limits to Wavefront Sensing with Spatial Mode Sorting

JianlingL@tla.arizona.edu — Mon, 28 Jul 2025 10:06:59 GMT

This technology is a next-generation wavefront sensor that leverages spatial mode sorting to achieve highly precise measurements of optical wavefronts. By optimizing the way light is analyzed, it allows for quantum-limited performance, making it significantly more sensitive and accurate than traditional wavefront sensors. This innovation is particularly beneficial for adaptive optics systems, such as those used in ground-based telescopes and high-precision optical instruments, where correcting atmospheric distortions is essential for clear imaging. Background: Ground-based telescopes fa...

A Deep Convolutional Neural Network Model for Rapid and Accurate Thermal Analysis of Computer Chips

JianlingL@tla.arizona.edu — Mon, 28 Jul 2025 09:37:51 GMT

This invention is a software-based solution that uses a deep convolutional neural network to predict how heat spreads across a computer chip. It enables engineers and designers to evaluate the thermal behavior of their chip designs quickly and accurately, without relying on time-consuming traditional simulation tools. By transforming a complex engineering problem into a fast machine learning prediction, this tool can help prevent overheating issues, improve device reliability, and streamline the chip development process. The model, called ChipThermNet, provides a major leap forward in chip th...

Autonomous Advanced Water Purification System Driven by Waste Heat

JianlingL@tla.arizona.edu — Thu, 17 Jul 2025 10:48:15 GMT

This invention is an autonomous, energy-efficient, and containerized system that produces two separate high-quality water products, one for non-potable use, such as in agriculture, and the other for potable use. The system utilizes waste heat as its primary energy source and combines membrane bioreactors and membrane distillation technologies. Background: Water purification systems are essential for providing clean, safe water for drinking, agriculture, and industrial use. Among advanced technologies, membrane bioreactors and membrane distillation have gained attention for their efficie...

Spring-Loaded Stabilization Device to Improve Walking

JianlingL@tla.arizona.edu — Mon, 14 Jul 2025 09:04:47 GMT

This invention is a spring-loaded stabilization device designed to enhance walking for individuals experiencing muscle weakness, or instability such as stroke, multiple sclerosis (MS), cerebral palsy, post-surgical recovery, spinal cord injury, or peripheral nerve damage. Older adults who are more prone to muscle weakness and instability may also benefit from this invention. The device passively supports the knee with a spring-loaded mechanism that helps control leg movement and reduce energy expenditure during walking. Early testing has shown it can lower the metabolic cost of transport by ar...

A Novel Method to Leach Chalcopyrite

JianlingL@tla.arizona.edu — Mon, 07 Jul 2025 12:24:37 GMT

This technology is an efficient and environmentally friendly method to leach chalcopyrite, one of the most abundant sources of copper and has been demonstrated to yield a copper recovery above 95%, compared to the current recovery of only 50%. The method does not use a smelter or an autoclave for extraction and can be conducted at ambient conditions in mining. This approach is effective across a wide range of pH solutions, is more simple and efficient than current methods, and reduces costs while supporting environmental sustainability. Background: Smelting, one of the primary tec...

Informed Arizona Equestrian Barn Smarts for Biosecurity

JianlingL@tla.arizona.edu — Mon, 07 Jul 2025 12:23:31 GMT

Informed Arizona Equestrian Barn Smarts for Biosecurity is a series of educational publications designed for youth and adults working with animals to promote better barnyard practices and reduce the risk of disease spread, including zoonotic diseases (those passed between humans and animals). The materials use simplified memes and cartoon illustrations to share key biosecurity tips in a clear and engaging way, focusing on horses, livestock, small stock, and other animals. Publications are available in English and Spanish, and select resources are available in a condensed poster version offered...

High Speed Amplitude-Based Liquid Crystal SLM

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:34:41 GMT

This invention pertains to a high-speed optical modulation device, specifically a liquid-crystal-on-silicon (LCoS) amplitude modulator using a thin nematic liquid crystal (LC) layer for ultra-fast switching. The modulator improves the manufacturability of high-speed optical devices, enabling applications such as chip-based camera arrays at a potentially lower cost. Background: Traditional high-speed optical modulators often use micromechanical mirrors, such as digital micromirror devices, but these are complex and expensive to fabricate. Liquid-crystal-on-silicon (LCoS) technology, whic...

Fano Resonant Optical Coatings for Multi-Wavelength Fluorescence Microscopy Applications

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:33:57 GMT

This invention uses advanced optical coatings to enhance fluorescence microscopy by combining two critical functions—filtering and splitting light—into a single, compact component. Streamlining these processes enables the precise isolation of light wavelengths while efficiently splitting them into multiple paths for imaging or analysis. It can be applied in various settings, from live-cell imaging to advanced microscopy techniques like super-resolution imaging and ratiometric sensing. By integrating these functions into one element, this technology enhances microscopy performance i...

Snapshot Wavefront Camera

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:30:16 GMT

This invention is a reference-free snapshot wavefront camera that can be used to measure both amplitude and phase of the wavefront. The camera uses a two-dimensional diffraction grating to split the incoming wavefront into multiple copies which then travel through a lens that focuses them onto a sensor in a camera array. The resulting wavefront information is encoded and captured by a camera array, and numerically decoded by a wavefront reconstruction algorithm. This method offers a significant advantage over existing techniques and its high space-temporal resolution is useful for studying fas...

Semiconductor-Piezoelectric Device With Low Self-Heating

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:27:53 GMT

This invention introduces a semiconductor-piezoelectric device designed to minimize self-heating while amplifying phonons efficiently. This technology tackles a major challenge in computer chips: overheating. By applying a special coating made from a thin layer of aluminum scandium nitride on a very thermally conductive base, it significantly improves heat removal from high-performance devices. This combination allows heat to flow away from the chip efficiently, preventing it from getting too hot. The heterostructure supports a Sezawa mode, optimized for maximal interaction between the electri...

Athermal Integrated Optic Device

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:27:09 GMT

The invention is an athermal waveguide device that helps counter the effects of parasitic, systematic, or environmental heat effects to improve optical device performance. The invention uses new combinations of materials that achieves the passive athermal performance of a silicon-based waveguide filter and also meets the very compact dimensions required by current Complementary Metal-Oxide-Semiconductor (CMOS) foundry standards. The device is both passive (meaning no power cost, making it less expensive) and scalable for mass manufacturing, making it a viable solution for the exponentially gro...

Integrated Diffractive-CMOS Optical Processor with In-situ Alignment and Reconfigurability

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:25:19 GMT

This invention is an integrated optical processor with diffractive elements through a CMOS chip. This technology addresses challenges associated with deploying free-space optical processors, such as diffractive networks, at optical wavelengths by integrating diffractive elements into the back end of the line of a CMOS chip. Leveraging the advanced fabrication capabilities of CMOS foundries, this approach enables the production of multiple layers with high alignment accuracy, essential for optical wavelength operations. This innovative hybrid diffractive-CMOS approach overcomes the alignment an...

Novel Approach to Minimize Unmodulated Light in Spatial Light Modulation

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:24:52 GMT

This invention is a novel approach to address the problem of unmodulated reflections in spatial light modulators (SLMs) that incorporates a perfect omnidirectional light absorber in the non-electrode areas of the SLM. The absorber is designed to be effective over a wide wavelength range, ensuring that any light incident on these regions is absorbed rather than reflected. As a result, the reflected light from the SLM consists solely of the modulated components, including both directly reflected modulated light and modulated diffracted orders. This approach significantly enhances the performance...

High-Speed Spatial Light Modulators Using Cascading Partial Phase Accumulation

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:24:19 GMT

This invention is a novel method to enhance the speed of spatial light monitors (SLMs), particularly for liquid crystal on silicon (LCoS) SLMs. The technology realizes SLMs that can increase the speed of liquid crystal SLMs by at least 2 orders of magnitude with little change on how these devices are made, and can be used to create future SLMs with speeds that are 5-6 orders of magnitude faster than the state of the art. Furthermore, the proposal extends this concept to another platform involving photonic resonances in electrooptic materials, such as lithium niobate. In this case, the resonanc...

Fluorescence-Guided Laparoscope with Microscopic Margin Analysis Capabilities for Surgical Guidance During Tumor Resection

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:23:35 GMT

This technology is a laparoscope that combines both white light and fluorescence imaging (WLFI) for wide field tumor localization and multiphoton microscopy (MPM) for microscopic surgical margin definition. The WLFI channel and MPM imaging channel are housed on an extendable arm on the laparoscope and images from both channels are displayed simultaneously on a computer via cable connection. These images are then analyzed by software using machine learning algorithms to determine probability of tissue being diseased in real time. Background: Laparoscopic surgeries are minimally invasive ...

Scalable Deformable Mirror Technology using Thin Mirror Substrate

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:22:52 GMT

This invention is a novel deformable mirror technology allowing the construction of deformable thin mirrors using a “green process” that allows for 90% of the manufacturing to be done using standard machining operations and finalized using classic optical process. By integrating these thin mirrors with a compact actuator array, the technology facilitates the scalability of deformable mirrors larger than 3 feet in diameter, offering benefits for optical applications, particularly space-based adaptive optics systems. Researchers developed a prototype 5 inches diameter. The use of a r...

High-Density Photonic Memory Through Multi-Layer Phase-Change Materials and Modal Interactions

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:22:16 GMT

This invention aims to advance the field of integrated photonic memory by introducing a high-density, multilayer storage approach. Utilizing phase-change materials (PCMs) as the active elements, the innovation leverages the unique near-field coupling profiles of different optical modes supported by a waveguide. Specifically, higher-order modes are used to selectively interact with multiple layers of PCMs, each serving as a bit of optical memory. It opens avenues for more complex and efficient computational tasks to be performed directly within the memory architecture. The long-term vision is t...

Monolithic Fabrication of Compact Cameras in in Standard CMOS Foundry Processes

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:21:17 GMT

This invention proposes a groundbreaking shift in Complementary Metal-Oxide-Semiconductor (CMOS) camera manufacturing by integrating all essential optical components—lenses, filters, and sensors—into a single CMOS chip using the same foundry process. Leveraging the existing back-end-of-the-line (BEOL) metal layers in standard CMOS processes, the technology repurposes these layers to serve as meta-lenses and plasmonic filters for color sorting. The CMOS camera innovation also promises enhanced performance in low-light conditions due to the efficient light capture of meta-lenses, op...

Monolithically Integrated Plasmonic Biosensors in Standard CMOS Technology for Ultra-sensitive and Multiplexed Bio-Detection

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:20:46 GMT

This invention proposes an approach to biosensing by monolithically integrating plasmonic elements with Complementary Metal-Oxide-Semiconductor (CMOS) sensors within a single CMOS foundry process. Utilizing the Back-End-Of-the-Line (BEOL) metal layers in a standard CMOS chip and exposing part or all of these metallic structures to introduce biomolecules, the design leverages nanophotonic resonances, such as propagating and localized surface plasmon resonances (SPR and LSPR), for highly sensitive bio-detection. This invention addresses several significant challenges in the realm of biose...

Lensless Imaging Using Standard CMOS Foundry Processes

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:20:06 GMT

This invention proposes an approach to camera fabrication by leveraging a single standard Complementary Metal-Oxide-Semiconductor (CMOS) foundry process. By repurposing the metal layers already present in CMOS chips to act as a scattering mask fabricated on top of a CMOS sensor array, the technology enables lensless computational imaging. This eliminates the need for complex, bulky lenses traditionally required in camera systems. The innovation significantly streamlines manufacturing by reducing complexity, alignment errors, material costs, and the overall size of the camera. This invention o...

Integrated Photonic Encoding Systems and Methods for High Speed and Low Power Image Processing

JianlingL@tla.arizona.edu — Wed, 02 Jul 2025 13:16:35 GMT

The photonic processing system described in this invention is able to perform large-scale matrix multiplication in an energy-efficient manner with the encoding matrix being designed such that encoded data can be decoded with high-fidelity for post-processing, such as reconstructing compressed images and image conditioning applications. In addition, this can enable image conditioning operations (e.g., denoising) to be selectively moved from an encoding stage at the front end of a processing pipeline to a decoding stage later in the processing pipeline. This photonic encoding and processi...

Adaptive Error Correction for Entanglement Distillation in Quantum Networks

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 14:44:44 GMT

This technology is a method of producing high-quality entanglement for quantum networking. It is a scalable, code-switching protocol for enhancing the fidelity of entangled states distributed across quantum repeaters. By using sequential rounds of quantum error correction and entanglement distillation with varying stabilizer codes to optimize the trade-off between fidelity and resource consumption, the approach allows for efficient and robust distillation strategies, adaptable to different network topologies and noise conditions, especially for depolarizing channels. With each round of d...

Universal Fault Tolerant Quantum Computation with Trotter Circuits

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 14:44:20 GMT

This invention introduces a novel approach to implementing fault-tolerant quantum circuits using Trotter circuits, which are essential for quantum simulations and other key algorithms. It provides a systematic framework for translating logical Trotter circuits into physical ones using symplectic transvections—algebraic structures that ensure the integrity of the logical operations and stabilizers. Quantum computing has the potential to revolutionize industries by solving complex problems exponentially faster than classical computers. However, quantum hardware is highly susceptible to err...

Grating-Resonant SNSPD Design for Enhanced Absorption Efficiency via Waveguide and Photonic Confinement

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 10:16:04 GMT

This invention presents a novel superconducting nanowire single-photon detector (SNSPD) design that significantly enhances photon absorption efficiency by combining waveguide redirection and lateral photonic confinement. The approach increases the effective absorption cross-section of the nanowire without lengthening it—overcoming a key limitation in traditional SNSPD architectures. Background: Superconducting nanowire single-photon detectors (SNSPDs) are essential in quantum communication, photon-starved imaging, and ultra-sensitive photon-level sensing due to their high timing r...

Ultra-Narrowband Induced Transmission Filter for EUV Lithography

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 10:15:23 GMT

This invention introduces a transmission-based induced filter operating in the extreme ultraviolet (EUV) regime. The purpose of the invention is to create high transmittance and ultranarrow band filters for EUV lithography even with losses. The filter is composed of EUV-compatible mirrors and a lossy medium. At the resonance frequency, there is minimal attenuation, despite the absorptive material in the cavity, because the induced transmission resonance enables constructive interference in transmission and reflective suppression. Background: High-numerical-aperture EUV lithograph...

Capturing Nano- and Micro-Objects in Predesignated Sites using Suspended Membranes

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 10:14:24 GMT

This invention introduces a novel method for capturing and positioning nano- and micro-scale objects at predetermined locations using suspended membranes. The technology leverages precisely engineered membrane structures to facilitate the controlled trapping of particles without requiring complex optical or mechanical manipulation techniques. This technique allows for deterministic, rather than random, placement of nanoparticles, which allows for precise spatial control of nanoscale objects. This approach enhances precision in microfabrication, biosensing, and nanotechnology applications. Bac...

Optical Readout of On-Chip Photodetectors Using Mach-Zehnder Interferometers

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 10:13:27 GMT

This invention presents a method for all-optical readout of detection events from on-chip photodetectors (PDs) using Mach-Zehnder Interferometers (MZIs). It eliminates the need for electrical wiring to transmit detection signals by leveraging optical modulation, providing a fully photonic detection and readout scheme. The system uses an integrated on-chip laser that serves as a common optical source, splitting light into multiple channels to feed each MZI. The MZI, connected to a photodetector, registers detection events via phase shifts, and the output is spatially resolved using grating coup...

Polarization Neutral Point Position Estimation Method

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 09:10:27 GMT

This invention is a location estimation method for the sky’s neutral points, specifically applied to the Babinet neutral point, that uses ultraviolet polarization imaging to determine the polarization signature of the sky. This invention further develops the Ultraviolet Linear Stokes Imaging Polarimeter (ULTRASIP), a ground-based instrument that captures ultraviolet light, to determine the position of the Babinet neutral point from linear Stokes images over 10 hours of observations. This invention has presented the first images of the Babinet neutral point in an ultraviolet waveband that...

Barettin Analogs

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 09:07:57 GMT

This invention features a novel barettin analogs, which are designed for the treatment of tuberculosis (TB) and chronic pain. Barettin, a naturally derived marine compound, has shown promising biological activity, and these synthetic analogs are optimized to enhance therapeutic effects while minimizing potential side effects. The innovation aims to offer a new avenue of treatment for two major health concerns with significant unmet medical needs. The analogs are structured to maximize efficacy and selectivity, with the potential to outperform traditional therapeutics. Their ability to treat tu...

Solar Control Coatings for Consumer Electronics

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 08:47:06 GMT

This invention is a coating for consumer electronic devices which is designed to reduce overheating under ultraviolet (UV), infrared (IR), or direct sunlight exposure while preserving high visible light transmission. This coating is adapted from solar reflective coatings in architectural windows and repurposed for electronic devices to maintain the display clarity. It can be retrofitted or integrated with consumer electronics such as cell phones, outdoor touchscreens, and other devices frequently exposed to sunlight. Background: Extended sun exposure, particularly from direct sunl...

Object Detection and characterization under low SNR conditions Using the Generalized Likelihood Ratio Test

JianlingL@tla.arizona.edu — Mon, 30 Jun 2025 08:46:43 GMT

This technology is a novel method for object detection in environments with significant scattering and other forms of interference. The approach leverages maximum likelihood estimation principles to achieve optimal object detection and characterization based on known physical models of scattering and emission from thermal emission, light scattering, or other detectable signatures. For any given signal, the likelihood that it was generated by interference or background noise is compared to the likelihood that it was generated by the presence of an object. These likelihood calculations are perfo...

Method for Fabricating Free-Standing Thin-Film Nanocomposites

JianlingL@tla.arizona.edu — Fri, 27 Jun 2025 09:58:28 GMT

This invention is a fabrication method for free-standing thin-film composites reinforced with nanofibers. These composites are on the scale of hundreds of nanometers to a few microns in thickness and exhibit strong mechanical integrity. The formation of ultra-thin, flexible layers without requiring a supporting substrate is broadly applicable across many industries including energy, healthcare, and wearable systems and allows for the development of structurally sound films suitable for integration into various devices and materials. Background: Thin-film technologies are critical ...

Free-Standing Metal Halide Perovskite Thin-Films

JianlingL@tla.arizona.edu — Fri, 27 Jun 2025 09:55:35 GMT

This technology is an ultralight, flexible metal halide perovskite thin film. Metal halide perovskites are semiconductor materials with unique properties that make them ideal for photovoltaic and optoelectronic applications. They are often used in solar cells. These metal halide perovskite thin films function without a substrate, making them ideal for ultra-lightweight applications and for applications in technologies with non-planar geometries like wearable electronics. Background: Typical metal halide perovskite thin-films function as thin layers applied to a glass substrate. Th...

One-Step Controlled Synthesis of Size Tunable Toroidal Gold Particles Using Green Chemistry

JianlingL@tla.arizona.edu — Fri, 27 Jun 2025 08:28:40 GMT

This invention is a method to control the size and shape of nanoparticles. It is a one-step synthesis process capable of tuning gold nanoparticles from 350nm to 1.7 microns using a process that has significantly reduced preparation time; it reduces hours for multi-step fabrication to 30-45 minutes. These synthesized toroidal particles exhibit surface features that may be used for a variety of applications in the near infrared-region and demonstrate a sensitivity two orders of magnitude greater than current gold nanostars. Also, a variety of different gold structures such as gold nanodendrites...

Solid Screw Removal Tool

JianlingL@tla.arizona.edu — Thu, 26 Jun 2025 15:40:03 GMT

This invention is a device that grips the head of a solid screw and pulls it back while the screwdriver is turned to remove the screw. While there are many different designs that are associated with different screw malfunctions, this tool is specifically designed to remove loose solid screws. Background: The market for orthopedic screw removal technology has very diverse players of all different sizes across the globe. Associated technologies offer an extremely diverse number of ways to extract surgical screws, and much of the recent market focus has been on compromised screw removal. T...

Application of Polarization Imaging in Identification and Metrology of Gemstone

JianlingL@tla.arizona.edu — Thu, 26 Jun 2025 09:46:17 GMT

This invention presents a method and instrumentation for gemstone identification and metrology using polarization imaging. It is a simple and cost-effective metrology system that distinguishes gemstones of various materials and cuts. The invention uses a combination of filters, a polarization camera, and other elements to form an image of the gemstone, from which parameters can be calculated and used to analyze the gemstone. Background: Gemstone metrology plays a crucial role in research and development, appraisal, design, and the production of gemstones and jewelry. Natural and synthet...

Fifth Harmonic and Five-Photon Excitation Fluorescence Multiphoton Microscopy

JianlingL@tla.arizona.edu — Mon, 23 Jun 2025 10:28:43 GMT

This technology introduces a fifth-order multiphoton microscopy system. This advanced method enables high-resolution, label-free imaging of biological samples using nonlinear optical effects. Laser scanning multiphoton microscopy has gained prevalence across a wide range of applications due to its high-resolution imaging potential. This system uses both fifth harmonic generation and five-photon excitation signals, enabling the use of longer pump wavelengths. These longer wavelengths can be useful in a wide range of scientific applications, such as biological research, materials characterizatio...

Spinal Cord Paddle to Induce Local Hypothermia

JianlingL@tla.arizona.edu — Mon, 23 Jun 2025 10:27:53 GMT

This technology is a therapeutic device that provides targeted hypothermia via a paddle to injured spinal cord patients. The system is designed to provide and maintain subfreezing temperatures for 4-5 hours, followed by controlled rewarming over a 20-hour period. The device is manually adjusted to maintain the target cooling profile, and real-time temperature data is displayed on an interface via paddle-integrated thermistors for monitoring purposes. The device offers a localized alternative to systemic hypothermia, reducing risks such as cardiac arrhythmias and coagulation issues. Back...

Artificially Intelligent Comprehensive Debriefing Assessment Tool (AICDAT)

JianlingL@tla.arizona.edu — Mon, 23 Jun 2025 10:26:43 GMT

Artificially Intelligent Comprehensive Debriefing Assessment Tool (AICDAT) is an AI-based platform developed to evaluate debriefing sessions in scenario-based medical simulations (SBMS). By analyzing transcripts from these sessions using proprietary algorithms, AICDAT provides structured, individualized feedback. It scores across elements of debriefing such as educational technique, outcome quality, and coaching effectiveness. The tool delivers real-time or asynchronous evaluation results directly to facilitators, offering a consistent, time-efficient, and unbiased alternative to traditional m...

Artificially Intelligent Procedural Assessment Tool (AIPAT)

JianlingL@tla.arizona.edu — Mon, 23 Jun 2025 10:26:03 GMT

The Artificially Intelligent Procedural Assessment Tool (AIPAT) is an advanced AI-driven system designed to evaluate healthcare professionals' performance of invasive medical procedures using recorded instructional videos. It utilizes deep learning techniques and machine learning algorithms to analyze instructional videos and apply standardized assessment criteria. AIPAT provides a scalable, objective, and time-efficient framework for assessing technical competence across a wide range of clinical skills, with demonstrated success in procedures like peripheral intravenous catheter (PIVC) pl...

Water Immersion Multi-Slit Portable In Vivo Confocal Ophthalmoscope

JianlingL@tla.arizona.edu — Wed, 18 Jun 2025 10:22:50 GMT

This technology is a low-cost, portable, scan-less in vivo confocal ophthalmoscope (PICO) that uses a water-immersion objective lens in combination with a multi-slit illumination and detection system. It enables high-resolution, non-invasive imaging of the anterior segment and external structures of the eye at the cellular and subcellular level. The device leverages grating-based confocal microscopy for compact design and faster imaging speeds, all without moving components. Background: Many current in vivo confocal imaging systems are costly, bulky, and require direct eye contact, whic...

Elastic Waves With Correlated Directional And Orbital Angular Momentum Degrees Of Freedom: A Method For Creating Bell States Using Elastic Waves

JianlingL@tla.arizona.edu — Tue, 17 Jun 2025 13:28:44 GMT

This invention is a method for generating classically nonseparable elastic wave states using a system of coupled one-dimensional waveguides. These wave states exhibit correlations between directional propagation and orbital angular momentum (OAM), producing a unique form of entanglement-like behavior using purely mechanical components. These nonseparable states can be reliably created and controlled by tuning how the system is excited, offering a new way to encode and process information. The invention introduces a mechanical platform that mimics features of quantum entanglement but operates e...

Secret Key Distillation over Realistic Satellite-to-Satellite Free-Space Channel Defense Strategy: Exclusion Zone Analysis

JianlingL@tla.arizona.edu — Tue, 17 Jun 2025 13:28:35 GMT

Quantum Key Distribution (QKD) is a system made possible by the advances in quantum computing and entanglement-assisted communication. QKD is currently in use for some companies trying to encrypt and secure their information in a way that makes it practically impossible to “crack” the encryption. The question then becomes: what is the limit for this technology? For companies currently trying to encrypt information sent between satellites, for example, are there limiting principles that can guide the allocation of resources for information encryption? This technology shows the...

Using Sound Waves to Modify Propagation Characteristics of Biological Calcium Signaling

JianlingL@tla.arizona.edu — Tue, 17 Jun 2025 13:28:08 GMT

This invention is a new method of interaction between sound waves and biological tissues, thus enabling regulation of biological activity. Background: Acoustic technology uses sound waves for sensing and therapeutic uses on tissues. Currently no sound wave therapy systems accurately target biological regulators of intercellular calcium signaling. This technology applies acoustic technology to sense and control intercellular calcium signals signals, affecting biological phenomena and diseases. Applications: Sound-based biological sensors and therapies Advanta...

Machine Learning-Optimized Estimation of Global Rainfall Erosivity Using IMERG Precipitation Data

JianlingL@tla.arizona.edu — Thu, 12 Jun 2025 09:11:19 GMT

This is an open-source machine-learning based method of estimating errors associated with global rainfall erosivity calculations based on IMERG (Integrated Multi-satellite Retrievals for Global precipitation measurement) data. The error estimation is developed by first analyzing IMERG-based erosivity data against reference datasets based on measurements from in-ground gauges. Then, datasets of auxiliary variables are used to attribute error sources and drive machine learning models to correct the errors. Ultimately, this error estimation and correction will be used to develop a tool for the re...

Reflex-o-Meter

JianlingL@tla.arizona.edu — Tue, 10 Jun 2025 12:16:11 GMT

The Reflex-o-Meter is a novel system designed to support clinical training, telemedicine, and future robotic healthcare applications by quantifying deep tendon reflexes (DTRs). It integrates miniature motion sensors into a standard reflex hammer and pairs them with sensors placed on a patient's limb to record and transmit reflex response data. The collected data—transmitted wirelessly to a mobile device or computer—enables real-time analysis of reflex force and limb response, enhancing both educational and diagnostic capabilities. This technology offers objective feedback for s...

Notice.Care.Help

JianlingL@tla.arizona.edu — Mon, 09 Jun 2025 18:40:31 GMT

Notice.Care.Help. is an innovative training program that forms an integral part of the “Together We Care” initiative which aims to foster a community-wide approach to mental health, emphasizing that it’s not just an individual concern but a collective responsibility. Notice.Care.Help. specifically equips university staff with essential knowledge and skills to recognize signs of students facing mental health challenges, cultivate a culture of care within the university community, and provide appropriate assistance based on their roles as employees. By sensitizing staff to the ...

Treadmill with Soft Ambulatory Surfaces

JianlingL@tla.arizona.edu — Mon, 09 Jun 2025 09:36:31 GMT

This invention is a specialized treadmill to study rat gait and mobility on simulated extraterrestrial terrains. This treadmill uses various harness-based gravity simulators and sensors for real-time physiological data collection. It can be used on a variety of ambulatory surfaces and used for many different applications. Background: Currently, there are various small animal treadmills that can be used for gait research and analyzing animal mobility. However, there are no small animal treadmills that simulate extraterrestrial terrains. This invention helps with specialized animal...

Lunar Coronagraph

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:49:16 GMT

This technology is a sensing system designed to detect and image objects in space near the moon, which are difficult to image with standard telescopes due to the moon’s brightness. This system is a dedicated coronagraph where the straylight from the Moon is significantly suppressed enabling us to track cislunar objects very close to the Moon. Traditionally, coronagraphs have been used to study the Sun’s atmosphere, the solar corona, and detect exoplanets around stars. This invention adapts the coronagraph technology for near-lunar applications, where the Moon’s brightness oft...

High-Secured Ultrafast Quantum Communication

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:48:30 GMT

This technology is a method for secure, high speed quantum communication that uses ultrafast squeezed light. This ultrafast squeezed light Is generated by directing quantum light generated by a light field synthesizer (LFS) onto a silicon dioxide target. This light, which is generated at a petahertz-scale frequency, is used for quantum communication by encoding information into its waveforms. The squeezed light is transmitted to a receiver, and characteristics of the light crucial to decoding are communicated separately to decoders at the receiver. If the squeezed light is intercepted as it tr...

Optical Enhancement of Phase Modulation Depth for a Phase Light Modulator

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:23:49 GMT

A phase light modulator (PLM) is a device that modulates phase of light in a 2-dimensional manner. This innovation is a method for optical enhancement of phase modulation to overcome the challenge of insufficient phase modulation of PLM in general, including Liquid Crystal on Silicon (LCoS), liquid crystals (LC), Micro Electro Mechanical System (MEMS) and others. By the method, insufficient phase modulation, or insufficient range of the mechanical displacement of micromirrors used with longer wavelength is optically enhanced. Consequently, diffraction efficiency is increased at longer waveleng...

MEMS Based Beam Steering with DC and Side Lobe Suppression

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:23:26 GMT

This technology is a system and method for a wide field of view micro-electrical mechanical (MEMS)-based beam steering device that uses spatial light modulation to suppress problematic effects like DC and side lobe diffraction in applications like LIDAR. Background: Laser beam steering is an indispensable feature of light detection and ranging (LIDAR) systems. Diffractive beam steering offers a low-inertia steering mechanism that is inherently more reliable than purely mechanical methods. In this approach, the phase of the laser is modulated in a pixelated pattern. The phase tilt...

Integrated CMOS Spectrometer: Revolutionizing Spectroscopy through In-Chip Diffusion Technology

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:21:51 GMT

This invention is a novel spectrometer design which integrates the diffusing component directly into a Complementary Metal-Oxide-Semiconductor (CMOS) sensor array, thereby enhancing compactness and manufacturing efficiency. The core innovation lies in repurposing one or more metal interconnects in the back end of the line of the CMOS chip to act as a diffuser. This method scatters incoming broadband light across the sensor array, enabling the spectrometer to decode the light's spectrum effectively. Key to this design is the high reproducibility and precision of CMOS foundry processes, whic...

Schlieren Imaging System using Thin Film Stack Optical Coatings or Metasurface Filters

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:20:25 GMT

This technology involves the use of thin film stacks or metasurfaces as spatial filters in Schlieren imaging systems for optical diagnostics. By design, these materials possess inherent spatial filtering properties, eliminating the need for the precise mechanical alignment required by knife-edge setups and simplifying the system’s assembly and operation, making it more accessible and user-friendly for various applications. Unlike the traditional knife-edge method, which necessitates choosing between blocking either positive or negative spatial frequency components, this new approach capt...

Vertical/Slanted Distributed Fiber Optic Sensing for Seismic Monitoring and Earthquake Prediction

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:11:56 GMT

This invention introduces a vertical/slanted distributed fiber optic sensing system for advanced earthquake prediction and seismic monitoring. It uses fiber optic sensors embedded in vertical or slanted boreholes to monitor seismic activity through distributed acoustic sensing (DAS), temperature sensing (DTS), strain sensing (DSS), and other techniques. By embedding the sensing fibers into an array of bore holes placed strategically in the ground in the region being tested, both vertical and horizontal coverage are provided. The data gathered by the embedded sensing fibers is then analyzed wit...

Remote Power Delivery, Heating, and Cooling Via Optical Fibers

JianlingL@tla.arizona.edu — Thu, 05 Jun 2025 13:10:11 GMT

This invention is a method for remote power delivery, heating, and cooling that leverages lasers and optical fibers for use in locations where traditional electrical systems are impractical. High-power laser light is transmitted through optical fibers—single-mode, multi-mode, or double-cladding—to remote locations, where thermoelectric generators (TEGs) and photovoltaic detectors convert the laser light into electrical energy. This system not only provides reliable power but also enables precise remote heating and cooling through thermoelectric cooling (TEC) systems. It also allows...

SAMURI-Self-Administered Multiplex Universal Radiation Indicator

JianlingL@tla.arizona.edu — Wed, 04 Jun 2025 10:12:14 GMT

SAMURI is an innovative point-of-care biodosimetry screening kit designed to detect and measure specific proteins and transcripts within leukocytes that serve as radiation biomarkers. The kit utilizes a vertical flow immunoassay, integrating all the necessary components for sample collection, preparation, bioassay, detection, automated data analysis, and reporting into a single point-of-care solution kit. Its primary purpose is to quickly differentiate between individuals who have been exposed to radiation and those who haven't, making it particularly useful during triage after a radiologi...

Biological Specimen Sample Preparation Apparatus for Self-Use

JianlingL@tla.arizona.edu — Wed, 04 Jun 2025 10:11:30 GMT

This invention is an apparatus with an integrated module based on a cap/tube configuration for biological specimen self-collection. A biofluidic sample, such as blood, is collected and inserted in the sample container of the sample prep module (SPM). Once inserted, the whole blood is dispensed in the chamber for a protein-based biomarker assay where the biofluid is subsequently mixed with a buffer and magnetic beads. A magnet is placed beside the tube at the base to retain cells of interest and any unwanted material is flushed out and absorbed on a pad within the central chamber of the top con...

Companion Diagnostic for Immunomodulatory Repair Treatments

JianlingL@tla.arizona.edu — Fri, 30 May 2025 09:37:50 GMT

This technology is a diagnostic tool designed to help match patients to specific drugs or therapies to treat chronic ischemic heart failure. The platform focuses on immune cells called macrophages, which play a crucial role in the body's response to injury and disease. By promoting a specific type of macrophage known to aid healing, this system supports the development and testing of new therapies. It also helps ensure the quality of these treatments and creates companion diagnostic tools to guide patient care during clinical trials. The technology has been tested in various animal models,...

Using Audible EEGs for Assisting in Brain Disease Diagnosis

JianlingL@tla.arizona.edu — Wed, 28 May 2025 09:36:36 GMT

This technology makes electroencephalogram (EEG) recordings audible to hear differences in real time by putting the filtered waves through an algorithm. This allows specialists to better identify where brain activity is different in real time rather than through visual analysis, which may take longer and may be harder to capture. Background: Currently, electroencephalograms (EEGs) are used to identify abnormal brain activity by trained neurologists. These EEG recordings are assessed for unhealthy control expectations. In pre-clinical settings, neuron activity has been listened to ...

Predictive mRNA Biomarker for Progressive Coccidioidomycosis When Infected

JianlingL@tla.arizona.edu — Mon, 19 May 2025 08:59:48 GMT

This invention introduces a blood-based diagnostic test to assess coccidioidomycosis progression risk. The test is broken down into three overall steps: 1) blood collection, 2) ex vivo stimulation, and 3) mRNA quantification. This technology identified a predictive a gene set/biomarkers for coccidioidomycosis that was independently validated across patient populations. Background: Coccidioidomycosis is a fungal infection also known as Valley fever. In many, infection causes no illness. In most others, it produces pneumonia and numerous other symptoms that last for weeks to m...

Apodized Prism Coupler for Optimized Evanescent Mode Matching Between Optical Fibers and Integrated Waveguides

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:08:29 GMT

This invention is a novel optical coupling apparatus and method that uses a prism-based coupler with an apodized coupling region to optimize mode matching between an optical fiber and an on-chip waveguide. This invention adapts apodization for prism coupling. It shapes the diffracted output field into a Gaussian-like profile that closely matches the mode field distribution of a standard single-mode fiber. Background: Current solutions for optical coupling can have losses and problems with efficiency with uniform couplers, little applicability to other optical uses, and misa...

Backside-Patterned Nanostructured Lens in BSI CMOS Sensors

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:07:47 GMT

This invention introduces a novel approach to enhancing backside-illuminated (BSI) Complementary Metal-Oxide-Semiconductor (CMOS) sensors by integrating patterned nanostructured lens elements, such as metalenses, directly into the backside silicon layer or additional material layers. Unlike conventional microlens arrays, these nanostructured lenses improve light collection efficiency, simplify sensor design, and reduce system complexity by eliminating the need for external microlenses and color filters. The fully CMOS-compatible fabrication process ensures seamless integration within standard ...

Multilayer Stacking for High Aspect Ratio Feature Formation

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:07:09 GMT

This invention introduces a novel fabrication method that enables the formation of high aspect ratio features in non-silicon materials. Unlike conventional deep reactive ion etching (RIE), which struggles with certain materials, this technique sequentially builds structures through multiple cycles of resist patterning, deposition, and alignment. By leveraging conformal deposition materials like silicon nitride, the process achieves mechanically stable, high aspect ratio features without requiring a single deep etch. This method results in a vertically assembled structure with the desired high ...

Method for Integrating Quantum Emitters as On-Chip Light Sources in Photonic Integrated Circuits Fabricated on Membranes

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:06:29 GMT

This invention presents a high-precision, scalable method for integrating quantum emitters as on-chip light sources in photonic integrated circuits (PICs) fabricated on thin-film membranes (e.g., SiN membranes). By utilizing nanopore trapping and deterministic positioning, this method enables precise placement of quantum dots (QDs), atomic defects, or other nanoscale emitters. The resulting integration enhances the coupling efficiency between emitters and waveguides, supporting coherent, directional emission suitable for high-speed optical communications and quantum photonic applications. ...

Engineered Mirror to Increase the Radiative Cooling Capacity of Windows

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:05:44 GMT

This technology introduces a novel mirror-based system designed to enhance the radiative cooling performance of windows. By reflecting thermal infrared (IR) radiation emitted by the window toward the sky while blocking ambient IR radiation from the ground, the system improves passive cooling efficiency. The mirror is coated with a spectrally selective material that reflects mid-to-far IR wavelengths (8–13 μm) while absorbing visible and near-infrared sunlight, preventing unwanted heating inside buildings. This innovation reduces reliance on air conditioning, enabling lower energy cons...

Polarization-Dependent Dual-Focus Metalens System for Simultaneous Reticle Illumination

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:04:34 GMT

This technology is a novel dual-focus metalens system for lithography applications. It uses as polarization-dependent metalens to focus light from a single source onto two separate reticles. This system can complete two parallel patterning tasks simultaneously, allowing for twice the throughput of traditional lithography systems. This, in turn, allows for increased efficiency in high-precision lithography-enabled processes like semiconductor fabrication. Furthermore, unlike current dual-focus lithography setups which require multiple light sources, this system uses only one light source and on...

Pressurized Gurney/Stretcher

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:02:31 GMT

The pressurized gurney/stretcher is a medical transport device that integrates a hyperbaric environment into a standard gurney. Designed for individuals suffering from decompression sickness or acute mountain sickness, it provides immediate stabilization in remote locations where traditional hyperbaric chambers are unavailable. The system uses a flexible, malleable fabric pressure system to create a controlled environment for the patient during transport, allowing treatment to begin en route to a medical facility. This ensures continuous care from the site of the emergency to definitive treatm...

Impactra

JianlingL@tla.arizona.edu — Mon, 12 May 2025 13:01:43 GMT

Impactra is a protective system designed to enhance astronaut safety in space by shielding them from ionizing radiation and potential impacts from micrometeoroids and orbital debris (MMOD). It incorporates high-density polyethylene (HDPE) or similar hydrogen-rich materials into spacesuit exteriors or internal layers, providing a lightweight yet effective armor-like barrier. This technology functions as an advanced protective shell, reinforcing existing spacesuits without significantly increasing weight or restricting mobility. This approach improves astronaut safety in deep space missions by p...

Infectious Cloned Cacao-Infecting Badnavirus Genomes

JianlingL@tla.arizona.edu — Mon, 05 May 2025 09:42:09 GMT

This technology involves the development of infectious cloned genomes from multiple species of badnaviruses that infect cacao (Theobroma cacao) trees. These infectious clones allow researchers to study how the viruses interact with cacao plants to cause and spread disease. The clones are constructed using well-established vectors and can be used to reproducibly infect plants in a controlled laboratory setting, enabling consistent disease modeling. By creating infectious clones of specific badnavirus species known to severely impact cacao production, this innovation provides a powerful research...

Encoding Quantum Information by Stabilizer Measurement and Utilizing the Syndrome for Decoding

JianlingL@tla.arizona.edu — Mon, 05 May 2025 09:25:43 GMT

This invention presents an efficient method and system for encoding quantum information using stabilizer-based QLDPC codes. In this method, low-weight stabilizer generators are used to encode quantum information. Each stabilizer generator acts on a limited number of qubits, minimizing the complexity of decoding and error detection. Then, an iterative decoding algorithm based on belief propagation is used to perform error correction. This decoding method is optimized to work efficiently and effectively with QLDPC codes. Background: Quantum error correction is a critical requirement for r...

A Method and Apparatus for Simultaneous Correcting Qubit Errors and Quantum Gate Errors

JianlingL@tla.arizona.edu — Mon, 05 May 2025 09:25:30 GMT

This technology is a quantum error correction system based on quantum low-density parity-check (QLDPC) codes. Many quantum computing systems rely on topological codes, which require increasing numbers of qubits to handle error correction longer code, limiting their scalability. QLDPC codes offer a more efficient alternative, achieving error correction while requiring far fewer qubits. However, QLDPC codes come with challenges like error degeneracy and inefficiencies that must be overcome before they are practical for real-world applications. This quantum error correction system uses an iterati...

A Swarm Flyby Technique for Characterizing Spaceborne Objects

JianlingL@tla.arizona.edu — Mon, 28 Apr 2025 09:22:43 GMT

This technology is a method for the 3D imaging of spaceborne objects such as near-Earth asteroids. The imaging is performed by a swarm of 6U CubeSats, each equipped with its own propulsion system and camera. The CubeSats utilize advanced sensing and communications systems to coordinate with one another and capture a high-resolution 3D image of a targeted object in a single high-speed flyby. By using a high-speed flyby, this approach bypasses many of the costs and challenges associated with the coordinated rendezvous required for proximity operations. This approach offers increased fuel efficie...

Consistent and Compliant Access Control in Microservice Systems

JianlingL@tla.arizona.edu — Wed, 23 Apr 2025 09:39:47 GMT

This innovation offers a new way to verify access control policies across microservice systems using constraint modeling. Instead of relying on manual checks or inconsistent logic spread across endpoints, this method introduces a structured and automated approach to ensure secure authorization is applied consistently throughout an entire system. Developers benefit from reduced workload, while organizations gain more confidence that policies are enforced correctly and uniformly, especially important as systems grow more complex. Background: Modern microservice systems often suffer from i...

Topological Quantum Analogue Computing using Classical Nonlinear Granular System

JianlingL@tla.arizona.edu — Mon, 21 Apr 2025 08:54:48 GMT

This technology is a quantum computing platform that uses the topological features of a classical nonlinear granular computing system to simulate quantum-like behavior using "elastic bits." These elastic bits emulate qubits by maintaining stable state integrity at ambient temperatures without the decoherence issues of quantum systems. This allows for quantum analogue computing: quantum logic and operations performed using a classical system. This quantum analogue computing method bypasses many of the challenges associated with quantum computing, such as the need for specialized, extr...

Method for Multilayer Nanophotonic Effective Medium Optics via Spin-Coated Planarization Layers

JianlingL@tla.arizona.edu — Mon, 21 Apr 2025 08:53:40 GMT

This technology introduces a novel method for fabricating multilayer nanophotonic devices using spin-coated planarization layers. The process ensures precise alignment and spacing between optical layers, enabling the creation of advanced optical elements for photonic computing and compound lenses. Spin coating is a procedure used to deposit uniform thin films onto flat substrates. By leveraging spin-coating techniques, the technology simplifies the integration of multiple optical layers, resulting in highly efficient and scalable solutions for nanophotonic systems. Background: Producing...

Optical Elements from Thin Film Coatings

JianlingL@tla.arizona.edu — Mon, 21 Apr 2025 08:52:57 GMT

This technology enables the creation of advanced optical elements through thin film coatings. By spatially varying the thickness, order, and material composition of thin film stacks, the technology allows for precise control of light's phase and amplitude. It is particularly advantageous in the extreme ultraviolet (EUV) wavelength range, where traditional optical systems struggle. This approach facilitates the design and fabrication of metasurfaces, metalenses, and other high-efficiency optical components, opening up new possibilities for EUV applications in lithography, imaging, and micro...

Optical Elements Through Phase Control Using Effective Medium Approach in Thin Films and Membranes

JianlingL@tla.arizona.edu — Mon, 21 Apr 2025 08:52:00 GMT

This invention introduces a novel method for designing optical elements, such as lenses, by using the effective medium theory (EMT). By employing subwavelength patterns in thin films or membranes, the technology creates localized refractive index changes that enable precise control over the behavior of light. This approach is particularly effective in ultraviolet (UV), deep ultraviolet (DUV), and extreme ultraviolet (EUV) wavelength ranges, offering a scalable and versatile solution for developing high-performance optical systems. Unlike traditional doping methods, this innovation achieves ref...

Personalized Motion Prediction for Enhanced Performance and Safety

JianlingL@tla.arizona.edu — Mon, 21 Apr 2025 08:49:23 GMT

This technology leverages artificial intelligence (AI) and motion capture to analyze and predict human movement patterns. Using video-based tracking and sensor data, it creates a personalized digital model of an individual’s biomechanics in different movements (e.g. sitting, walking, squatting, other functional movements, etc.). This model can simulate how a person moves in different environments or under various conditions, such as fatigue or injury, to optimize performance and prevent injuries. The system is designed for applications in rehabilitation, sports, occupational safety, and ...

Architectural Change Impact Analysis in Microservice Ecosystems

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 12:40:29 GMT

This invention is for a software service that mitigates architectural degradation during complex multi-team projects that aim to develop several different microservices in parallel. This new, cloud-native approach involves decentralization with selective scalability leading to enhanced developmental processes and communication structures. Background: Microservice systems are the mainstream in the IT industry that create resilient and scalable solutions. Such systems easily become complex as they are developed by multiple teams who manage different microservices in parallel. This causes ...

Learning Decoders for QLDPC Codes Using Importance Sampling

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 12:39:10 GMT

This invention proposes a novel framework for error correction in Quantum Low-Density Parity-Check (QLDPC) codes, which are important for fault-tolerant quantum computation. These error correction codes are used for the transmission of data. Quantum low-density parity-check (QLDPC) codes with asymptotically nonzero rates are promising candidates for fault-tolerant quantum computation. This invention proposes a general framework for error correction for a class of QLDPC codes called lifted-product codes using recurrent neural networks (RNNs). The RNN is employed to learn message passing rules t...

AI-Assisted Computational Prediction of Protein Functionality

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 09:54:01 GMT

This invention centers on creating a database and algorithms to explore protein functionality and interactions. The aim is to enable significant scientific discoveries, novel drug targeting, and the engineering of synthetic receptors like chimeric antigen receptors (CARs). By studying proteins involved in T cell activation over 450 million years of evolution, the project will develop machine learning and deep learning algorithms to identify critical functional networks within and between proteins. The technology leverages evolutionary data to find previously unknown intra- and inter-protein si...

Safety and Mobility Analytics in Real Time (SMART) Tool

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 09:40:47 GMT

The Safety and Mobility Analytics in Real Time (SMART) Tool is a sophisticated web-based platform designed to streamline transportation data management. Leveraging cutting-edge data analysis and visualization techniques, this suite enables users to gain valuable insights into the intricacies of traffic patterns, congestion points, and overall vehicular movement. By integrating diverse datasets and employing advanced visualization techniques, the SMART Tool empowers transportation agencies to analyze and monitor roadway networks in real-time or historically. This innovative platform provides in...

Hearing the Invisible

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 09:40:23 GMT

This is an immersive art experience in which individuals will walk through a model of a brain while using augmented reality (AR) for a more realistic, immersive experience. Attendees also listen to sonified electroencephalograms (EEGs) of healthy brains and brains with different diseases, such as dementia and Alzheimer’s which allows them to hear what the brain waves of practically invisible diseases sound like. Educational materials about the experience are also available via QR codes in the experience. Background: Immersive art experiences merge technology and art to creat...

Augmented Reality App for Audible EEG

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 09:40:08 GMT

This is an augmented reality app for use with the Hearing the Invisible immersive experience in which attendees listen to audio versions of electroencephalograms (EEGs) to hear the difference between healthy brains and brains with different diseases, such as dementia and Alzheimer’s. QR codes throughout the experience link to the app, which has educational materials about the exhibit. The app also enables toggling between EEG audios during the immersive experience. Background: Virtual reality and augmented reality are being increasingly used in connection with immersive art ...

Hearing the Invisible Original Composition

JianlingL@tla.arizona.edu — Thu, 17 Apr 2025 09:39:53 GMT

This is a live performance of an original composition created for the Hearing the Invisible immersive art experience using electroencephalograms (EEGs) as a base for the audio. It includes original vocal and electronic musical composition. Background: Music and/or other audio sounds can augment immersive art experiences. They can be original compositions, licensed audio recordings, or some combination. The original composition for Hearing the Invisible is unique because it incorporates audios of EEGs. Applications: Original composition Vocal and electronic music c...

'Martin Irrigation Head' for Solid Set Flood Irrigation

JianlingL@tla.arizona.edu — Mon, 14 Apr 2025 09:49:17 GMT

This invention is a high flow bubbler sprinkler head and method for crop irrigation. The “Martin Irrigation Head” modifies existing solid-set sprinkler irrigation pipe by replacing the sprinkler with a new irrigation head with a modification at the base that can be used to divert water flow out of the sprinkler head or out the bottom for flood irrigation. This method applies floodwater via sprinkler heads on pipes arranged in a grid layout instead of a single source. Initial design testing showed this design improved solid set flood irrigation efficiencies by 80% over existing meth...

Ophthalmoscopic Device and Method for Capturing Images using the Same

JianlingL@tla.arizona.edu — Mon, 14 Apr 2025 09:46:15 GMT

The invention is a low-cost, portable in-vivo confocal ophthalmoscope (PICO) designed to capture microscopic images of the anterior segment of the eye and external eye structures without direct contact. The device is compact, lightweight, and capable of providing high-resolution imaging for real-time diagnostics. This ophthalmoscope can attach to standard slit lamp biomicroscopy, making it easy to integrate into existing ophthalmic workflows. It provides rapid, non-invasive imaging and enhances visualization of cellular morphology associated with diseases, aiding in early detection and interve...

Method and Structure for Optical Coupling in Photonic Integrated Circuits Using Etched Silicon Substrates

JianlingL@tla.arizona.edu — Mon, 14 Apr 2025 09:38:48 GMT

This invention introduces a novel method and structure for optical coupling in photonic integrated circuits (PICs) using etched silicon substrates. These etched features allow light to be introduced from beneath the substrate and efficiently coupled into on-chip waveguides. It enhances the efficiency of photonic couplings, allowing multiple input modes to be excited with high density while reducing the overall size of the system. The approach leverages total internal reflection-based coupling, improving integration and performance within PICs. By eliminating the need for patterned gratings and...

Grassvasion Board Game

JianlingL@tla.arizona.edu — Mon, 07 Apr 2025 09:36:39 GMT

This invention is a National Science Foundation grant-funded semi-cooperative board game developed as an educational tool to teach players about the spread of invasive buffelgrass and fire risk management. Players assume different roles and earn points as individuals but may also work together cooperatively on shared goals to manage risk. This game would have an immediate audience in Southern Arizona to be distributed locally or nationally if possible. Background: Educational board games are a unique way to engage learners in fun, non-formal settings. Research has shown tha...

Wildfire Monitoring Using Polarization Sky Images of Neutral Points

JianlingL@tla.arizona.edu — Thu, 03 Apr 2025 15:35:48 GMT

The Ultraviolet Linear Stokes Imaging Polarimeter (ULTRASIP) is an advanced imaging system designed to track subtle changes in atmospheric polarization, providing a new way to assess air quality and detect and monitor environmental changes, such as wildfires. This ground-based instrument captures ultraviolet light to pinpoint the position of neutral points that are key atmospheric markers that shift due to changes in aerosols like wildfire smoke, dust, or pollution. By analyzing the sky neutral polarization points, this technology allows for continuous, precise measurements that are less affec...

Allopregnanolone (ALLO), the Pregnancy Neuro-Steroid, is Neuroprotective in Hypoxic-Ischemic Injury of the Immature Brain

JianlingL@tla.arizona.edu — Wed, 02 Apr 2025 10:17:34 GMT

This innovation focuses on the potential therapeutic use of Allopregnanolone (ALLO), a natural neurosteroid, to treat hypoxic ischemic (HI) brain injury in premature infants. ALLO, naturally produced in the placenta during brain development, is absent in premature infants, which contributes to the neurological deficits observed in HI cases. The proposed solution involves administering ALLO to enhance brain development, promote cell survival, and reduce neuroinflammation and glutamate excitotoxicity. In preclinical studies using a neonatal mouse model, ALLO treatment showed promising results in...

Automated Rockfall Recognition from Thermal Video using Computer Vision

JianlingL@tla.arizona.edu — Mon, 31 Mar 2025 14:48:30 GMT

This invention consists of an algorithm that utilizes computer vision and thermal imaging cameras to detect, track, and alert for hazardous fall events in environments with exposed and potentially unstable rock walls or structures. The Automated Rockfall Recognition system utilizes mathematical, non-machine-learning methods to identify rockfall events by using thermal video system with low resolution and low framerate thermal video inputs. It can alert users to rockfalls in environments with low visibility and other conditions that may hinder other monitoring technologies (e.g., fog, dust, dar...

Acoustoelectrically Enhanced Holographic Video

JianlingL@tla.arizona.edu — Mon, 31 Mar 2025 09:45:23 GMT

This invention improves acousto-optic devices by increasing their interaction length, allowing for better diffraction efficiency and higher resolution holographic displays with a wider field of view. By using an ultra-thin semiconductor film, the acoustoelectric effect amplifies surface acoustic waves, making them last longer and improving acousto-optic performance. This approach results in improved diffraction efficiency and a greater number of resolvable spots, supporting the development of transparent spatial light modulators for holography, particularly for augmented reality. Background:&...

Graph Theory Based Least Squares Optimization Algorithm for Behavioral Estimation (G.L.O.B.E.)

JianlingL@tla.arizona.edu — Mon, 31 Mar 2025 09:42:52 GMT

This is an advanced software tool that analyzes functional neuroimaging data to map brain oscillations and predict optimal task timing across cognitive domains. By integrating MRI-based connectivity data with user input, it provides insight into the understanding of how different brain states interact. This predictive software intends to provide recommendations for optimized task completion in several cognitive avenues including psychomotor vigilance, emotional regulation, and cognitive performance. Additionally, this software has the possibility to be applied in diagnostics as a measure of ci...

UV-Curable Disulfide Glass Photoresists and Photopolymer Resins

JianlingL@tla.arizona.edu — Mon, 31 Mar 2025 09:41:27 GMT

This invention introduces a new class of UV-curable Disulfide Glass (DSG) photoresists and photopolymer resins, designed for high-quality optical component fabrication and complex 3D printing. This polymer features exceptional optical transparency across the visible and infrared spectrum, coupled with robust thermomechanical properties, making it ideal for precision plastic optics. DSG offers a high refractive index (RI) and can be processed into thick, defect-free optical components, such as windows, lenses, and prisms. Its superior transparency surpasses common plastics like PMMA (Plexiglass...

New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 12:42:11 GMT

This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models. Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer and typical therapeutic options fail to hit the mark as drug toxicity affects the efficacy of common treatment options. This new therapeutic provides a new way to increase efficacy of existing ...

Expanded use of a Pill Containing Alpha-Galactosidase for Galactose-Alpha-1,3-Galactose Degradation to Treat Alpha-Gal Syndrome Patients

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:28:57 GMT

This innovation expands the use of an existing pill originally designed to aid in digesting soy products to help individuals with Alpha-Gal Syndrome (AGS), commonly known as red meat allergy. AGS is triggered by consuming products containing galactose-alpha-1,3-galactose (aGal), which is found in red meat, dairy, gelatin, and collagen-based products. This supplement has been found to break down aGal, potentially preventing allergic reactions in individuals with mild to moderate AGS. Repurposing this enzyme supplement offers a convenient, over-the-counter approach to managing AGS symptoms. Bac...

Highly Accelerated and High-Resolution T1-Weighted MRI

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:27:58 GMT

This invention is for an accelerated, high-resolution T1-weighted magnetic resonance imaging (MRI) via modification of the three-dimensional magnetization-prepared rapid gradient echo (3D MP-RAGE) sequence. Through this modification, optimization is achieved by allowing for faster signal collection and shorter acquisition time with generation of optimal contrast. This advancement can significantly improve clinical workflow, reduce MRI scan cost per subject, and minimize movement artifacts and discomfort for subjects. Background: Three-dimensional magnetization-prepared rapid gradient ec...

Acoustic Radiation Force Impulse Procedures for Modulating Glial Cells and Neurons in the Central Nervous System

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:26:53 GMT

This technology leverages focused ultrasound and Acoustic Radiation Force Impulse (ARFI) techniques to improve brain health by normalizing synaptic activity and enhancing waste clearance in the central nervous system. It provides two non-invasive procedures: one targets astrocytes to modulate synaptic activity, while the other stimulates the glymphatic system to improve the removal of harmful waste from the brain. These approaches are designed to address a range of brain disorders, offering potential therapeutic benefits without invasive surgery or drugs. Background: The invention addre...

Method and System for 360 Degree 3D Measurement of Complex Objects and Human Bodies

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:25:17 GMT

This invention presents a method for performing full-field 360-degree 3D measurements of complex objects and human bodies using advanced projection technology originally developed for virtual reality applications. Captured light reflected from the object’s surface as well as the surface shape are reconstructed using advanced 3D imaging technologies such as structured light, deflectometry, and photometric stereo to get the measurement. This invention has the potential to perform accurate 360-degree 3D measurements of complex objects with mixed reflectance properties, such as statues, larg...

Method and Device for Microscopic Imaging

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:24:30 GMT

This invention presents a novel method and optical design for microscopic imaging that achieves high resolution, wide field of view (FoV), and large imaging depth without requiring mechanical scanning elements. This involves leveraging a MEMS-based phase light modulator (PLM) device into the imaging path so that the system expands both spatial and axial dimensions, enabling dense imagery acquisition over a significantly larger probe volume. The modular design with a compact form factor allows for seamless integration with existing microscope systems, offering enhanced imaging capabilities acro...

Flexible Glass Interconnect Structures for Photonic Integrated Circuit

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:22:52 GMT

This technology introduces a flexible glass-based optical interconnect solution for photonic integrated circuits (PICs). It leverages a carefully designed array of high index and low index materials to make an optical connection that optimizes light coupling and reduces scattering and propagation loss. The method provides a solution to replace traditional electronic interconnect with a scalable, low loss, inexpensive optical connection with high yield and bandwidth. The method withstands temperatures above 200°C, making it suitable for advanced packaging and high-performance applications. ...

Monofunctional MDM2 Degraders for Disease Treatment

JianlingL@tla.arizona.edu — Mon, 24 Mar 2025 09:21:10 GMT

This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors. Background: The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United States for 2024 estimate that about 20,800 people will be diagnosed with AML. Most cases will be in adults, with about 11,220 people will die from AML. Current treatment options for AML and other cancer types, include MDM2 PROTACs, though th...

Methods and Systems for Optimizing Optical Cavities for Photoevaporation, Desalination, and Water Purification using the Photomolecular Effect

JianlingL@tla.arizona.edu — Tue, 18 Mar 2025 10:52:51 GMT

This technology leverages the Photomolecular effect to evaporate water at maximal efficiency. The Photomolecular effect is a recently discovered phenomenon in which polarized light, when directed at a water surface, causes water to evaporate at a higher rate than the expected thermal evaporation rate, allowing for the evaporation of water without heat. This technology uses the Photomolecular effect with a directed polarized light (e.g. lasers), in combination with strategically placed reflective surfaces, to induce maximal evaporation. These surfaces are coated to maximize reflectivity while m...

2D Electrochemical Scanning for Defects in Perovskite Films

JianlingL@tla.arizona.edu — Mon, 17 Mar 2025 11:38:30 GMT

This invention introduces a disposable, non-destructive electrochemical sensor designed to characterize and monitor reactive defects in lead halide perovskite solar cell layers during high-throughput manufacturing processes. The sensor provides real-time assessment of quality, stability, and durability under stressors such as humidity, light, and temperature. Unlike traditional methods requiring complex spectroscopic setups, this technology employs electrochemical techniques to detect defect concentrations. By integrating redox probes into the electrolyte, the sensor captures detailed defect d...

Kinase Suppressors for Cancer Therapy

JianlingL@tla.arizona.edu — Mon, 17 Mar 2025 11:36:24 GMT

Mixed Lineage Kinase 3 (MLK3) has been identified as a promising target for cancer therapy, particularly for addressing aggressive cancers such as triple-negative breast cancer (TNBC). TNBC is a challenging cancer type with limited treatment options and disproportionately affects certain populations. This innovative technology focuses on a series of novel MLK3 inhibitors designed to suppress the signaling pathways that promote cancer cell growth and survival. These inhibitors aim to induce apoptosis, reduce tumor progression, and potentially enhance the immune system’s response to tumors...

Enhanced Min-Sum Decoding of Quantum Codes

JianlingL@tla.arizona.edu — Wed, 12 Mar 2025 09:06:48 GMT

This technology is an advanced message-passing decoder called the Min-Sum with Past Influence (MS-PI) decoder, specifically designed for Quantum Low-Density Parity-Check (QLDPC) codes. The MS-PI decoder addresses critical challenges in quantum error correction by leveraging oscillatory message dynamics to enhance decoding performance, particularly for degenerate codes. Unlike conventional approaches, MS-PI achieves superior reliability without relying on complex serial scheduling or post-processing techniques, making it both efficient and scalable for real-world applications. Simulation result...

Eller PeaPod Virtual Alternative

JianlingL@tla.arizona.edu — Wed, 12 Mar 2025 09:02:55 GMT

This invention is a system designed to allow a single faculty member to teach a course from an originating location but have full interactivity with students participating from one or more locations. This technology includes high fidelity audio and video, content sharing, and live gradable participation. This system can be an add-on tool for video conferencing programs to provide organization-specific enhancements. Background: Popular videoconferencing programs such as Zoom, Microsoft Teams, and WebEx are used in a variety of environments, but have limited audio and video control,...

Apparatus and Method for Powering High Temperature Chemical Reactions using Solar Energy

JianlingL@tla.arizona.edu — Wed, 12 Mar 2025 09:01:43 GMT

This invention is a novel apparatus and method for powering high-temperature chemical reactions, such as calcination, using a solar powered reactor for direct air capture (DAC) of CO2. The system features a tower-mounted reactor positioned above a field of twisting heliostats, which concentrate sunlight into a thermally insulated chamber. Within the chamber, sunlight is converted into thermal radiation to drive endothermic reactions in radially arranged processing tubes. The reactor is equipped with mechanisms for controlled feeding of solid reactants, gas collection, and solid product retriev...

Stress Induced Broadband Tunable Optical Waveplate

JianlingL@tla.arizona.edu — Fri, 07 Mar 2025 09:26:36 GMT

This invention discloses designs and methods for manufacturing a broadband optical waveplate capable of operating across ultraviolet (UV), visible, near-infrared (NIR), mid-wave infrared (MWIR), and long-wave infrared (LWIR) wavelength ranges. Waveplates, also called retarders, are optical components that manipulate light's polarization state, converting it from one polarization state to another. They are indispensable in optical systems and photonic devices, with applications spanning imaging, telecommunications, metrology, and display technologies. This waveplate's advanced design en...

Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides

JianlingL@tla.arizona.edu — Wed, 05 Mar 2025 09:09:51 GMT

This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner. Background: Fusing two proteins into a polypeptide can present engineering challenges when done in a traditional way because often it leaves the functional ends of the proteins in sub-optimal positions. This technology helps overcome th...

Methods and Apparatus for Crosstalk-Free Integral Imaging Based Light Field Displays using Directional Illumination Sources

JianlingL@tla.arizona.edu — Mon, 03 Mar 2025 08:35:54 GMT

This invention presents a method and apparatus for improving integral imaging-based light field head-mounted displays (HMDs) by addressing the intrinsic crosstalk issue. Conventional integral imaging-based head-mounted displays suffer from crosstalk due to the omnidirectional emission of typical micro-display panels, which reduces image contrast and accuracy. This technology addresses this issue by introducing directional illumination sources that effectively control light emission from micro-display panels. The proposed designs have been analyzed, implemented, and experimentally validated, de...

Intracranial and Cerebrospinal Fluid Deuteration using Heavy Water Isotopologues

JianlingL@tla.arizona.edu — Mon, 03 Mar 2025 08:34:31 GMT

This invention is a method of therapeutic intervention for primary and metastatic brain cancer, and other relevant nervous system derivates, via the deliverances of deuterated heavy water isotopologue. This novel treatment method offers promise for specificity improvements as it uses water to deliver its therapy, allowing for increased efficiency in crossing the blood-brain barrier after treatment. Background: According to the National Brain Tumor Society, an estimated 1 million Americans are living with a primary brain tumor. Brain cancer is estimated to be the 10th leading cause of ca...

Wafer-Scale Synthesis and Deposition of One-Dimensional Materials with Precisely Controlled Intervals on Thermally Treated Substrates

JianlingL@tla.arizona.edu — Mon, 03 Mar 2025 03:28:08 GMT

This invention introduces a novel method for wafer-scale alignment and synthesis of one-dimensional (1D) materials, using thermally treated substrates to create step-like surface features that act as templates for precise material deposition. This technique involves creating patterned features on the surface of a substrate using high-temperature annealing. The size of these step features can be controlled by adjusting the annealing temperature. These thermally treated substrates can then be used to produce stepped metal films. One substrate can undergo this process multiple times, making this ...

Diffractive Intraocular Lens and Contact Lens with High Efficiency

JianlingL@tla.arizona.edu — Fri, 28 Feb 2025 15:07:14 GMT

This invention is a highly efficient diffractive intraocular and contact lens designed to minimize glare, halos, and image artifacts to improve vision. The lens design enhances efficiency by precisely directing light into desired diffractive orders which ultimately enhances vision at multiple focal points. This is particularly beneficial for trifocal lenses. The design also considers low-light conditions, making them suitable for a wider range of everyday use cases. This invention represents a significant step forward in vision enhancement, delivering improved performance over existing lens te...

Digital Twin Platform for Smart Training and Assessment in Extended Reality

JianlingL@tla.arizona.edu — Mon, 24 Feb 2025 09:21:23 GMT

The Digital Twin Platform for Smart Training and Assessment is an innovative solution that combines extended reality (XR) and artificial intelligence to revolutionize training procedures across various industries. By autonomously generating digital twins of training processes from only video inputs, the platform allows for an immersive, interactive training experience that can be tailored to individual needs. Leveraging large language models (LLMs), it efficiently extracts instructional content and action requirements, reducing the need for manual input and enabling seamless scalability. The p...

Displacement and Acceleration Optomechanical Sensor

JianlingL@tla.arizona.edu — Mon, 24 Feb 2025 09:20:00 GMT

This technology is an optomechanical sensor primarily designed for displacement and acceleration sensing. This sensor uses a novel AC measurement technique to reduce interference from low-frequency noise such as 1/f electronics noise. This technique involves modulating the length of a micro-optical cavity, which can be done with a relatively simple setup. High sensitivity and cost-effectiveness are achieved through the use of low-cost fiber optic, optical, mechanical, and optomechanical components. Reducing the effect of 1/f noise through this method allows for simple, low-cost, high sensitivi...

Optomechanical Systems for Inertial Sensing

JianlingL@tla.arizona.edu — Mon, 24 Feb 2025 09:18:56 GMT

This technology is a series of novel optomechanical inertial sensing systems. The systems use advanced optomechanical accelerometers with laser interferometric displacement sensors to achieve high-sensitivity inertial sensing. These sensing systems are capable of operating at very low measurement frequency. Their compactness and robustness make them suitable for use in a wide variety of end-use industries and environments, with potential underwater, air, and space applications. By using a laser-based interferometric displacement sensor, the system achieves improved sensitivity and low noise. T...

Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization

JianlingL@tla.arizona.edu — Tue, 18 Feb 2025 08:27:46 GMT

This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting. Background: Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule linkage. The most common types of bioconjugation include coupling of a small molecule (such as biotin or a fluorescent dye) to a protein, including arguably the most common type, Antibody Drug Conjugates. These reactions encounter lim...

Degenerate Entanglement Assisted Communications

JianlingL@tla.arizona.edu — Mon, 17 Feb 2025 08:15:32 GMT

Degenerate Entanglement Assisted Communications is a cutting-edge quantum communication technology designed to significantly enhance data transmission efficiency while maintaining high security. This innovation eliminates the need for optical phase conjugation (OPC), a common limitation in traditional quantum communication systems, by leveraging degenerate parametric down-conversion to generate entangled photon pairs. Background: The primary challenge addressed by this technology is the inefficiency and vulnerability of classical and non-degenerate quantum communication systems. Traditi...

High Efficient Rodent Interspecies Rotational Head Trauma Instrument

JianlingL@tla.arizona.edu — Mon, 17 Feb 2025 08:13:10 GMT

This invention is a novel rotational traumatic brain injury (rTBI) model that delivers rotational impacts to the heads of rodents. This technology aims to provide a strong model for research of the pathophysiology of rTBI and help develop therapeutics. Background: Many traumatic brain injuries occur in the United States and result from sports accidents, traffic accidents, explosions, and other personal accidental injuries. Due to these events, traumatic brain injuries can cause detrimental effects on the average human being. Currently, most rTBI models fail to replicate specific c...

Dual Performing Vinyl-tetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins

JianlingL@tla.arizona.edu — Mon, 17 Feb 2025 08:06:24 GMT

This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific single-thiol targeting. This novel method possesses an electron withdrawing tetrazine substituted vinyl moiety that exists as a Michael receptor for selective conjugation with cysteine and a site for click with trans-cyclooctene (TCO) derivatives to introduce functionality. Background: Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows fo...

Eco-Friendly, Sustainable, Lightweight, Porous Cellulose Sponge for Crop Growth

JianlingL@tla.arizona.edu — Thu, 13 Feb 2025 12:56:26 GMT

This technology uses ‘cellulose sponges’ that can be used to grow pick-and-eat crops without soil. The inventors have tested diverse cellulose derivatives and have determined the best performers. Hydroxyethyl methylcellulose was shown in testing to have a higher water-retention property, higher durability, low density and malleability, and equal performance when compared to current rockwool systems. The crosslinked nature of the technology overcomes the common drawback of current sponges’ material releasing lots of dust and loose fiber that can be dangerous to humans in close...

Sensor-Based Prediction of Thermal Runaway in Lithium-Ion Batteries Through Strategic Sensor Arrays

JianlingL@tla.arizona.edu — Thu, 13 Feb 2025 11:04:00 GMT

This invention introduces a novel framework for predicting thermal runaway (TR) in lithium-ion batteries (LIBs) by combining strategically placed sensor arrays with machine learning models to predict TR events in lithium-ion batteries before they occur. TR is a phenomenon that occurs when the temperature in a LIB causes reactions to occur which produce more heat, which causes more reactions and is one of the leading causes of LIB fires. This technology uses an array of thermal sensors placed throughout a LIB module to collect real-time data. Then, a convolutional neural network-based machine l...

Multifunctional Solar Control Coating with Bird Collision Prevention Properties

JianlingL@tla.arizona.edu — Mon, 10 Feb 2025 08:11:49 GMT

This invention is an innovative window coating that combines two essential functionalities: solar control and bird safety. It blocks infrared (IR) and ultraviolet (UV) radiation to improve energy efficiency, reduce heat gain, and protect interiors from UV damage, while integrating a UV-reflective pattern to enhance window visibility for birds. The coating combines both energy-efficient solar control and bird safety into a single, integrated solution, offering a dual-purpose window coating. A low-emissivity infrared-reflective layer helps maintain a cooler interior environment, improving energy...

Metasurface-Based Faraday Isolator

JianlingL@tla.arizona.edu — Mon, 10 Feb 2025 08:11:24 GMT

This is an ultrathin Faraday isolator that combines polarization-sensitive metasurfaces with a few-micron-thick magneto-optical (MO) material to achieve efficient and compact optical isolation. By using metasurfaces, it minimizes the traditional size and material constraints of Faraday isolators. The metasurfaces diffract light at different angles based on its polarization state, enabling the isolator to direct light unidirectionally while requiring only minimal polarization rotation. Unlike conventional Faraday isolators that require substantial magnetic fields and thick materials to rotate t...

High Efficiency Colored Radiative Cooling Surfaces Through Narrowband Beam Deflection

JianlingL@tla.arizona.edu — Mon, 10 Feb 2025 08:10:44 GMT

This technology introduces a novel method for creating colored surfaces that preserve high radiative cooling efficiency. Traditional colored surfaces tend to absorb specific wavelengths of light, which increases surface temperatures and diminishes cooling capabilities. In contrast, this invention employs advanced metasurface-based beam deflectors to produce coloration through light scattering, rather than absorption. This approach enables these surfaces to deflect unwanted wavelengths while maintaining efficient cooling properties, making them ideal for applications requiring thermal managemen...

Superresolution Imaging via Utilizing Plasmonic Photothermal Redshift Filtering

JianlingL@tla.arizona.edu — Mon, 10 Feb 2025 08:08:02 GMT

This invention introduces a novel metamaterial emitter system designed to enhance super-resolution imaging by leveraging the interaction between plasmonic nanoparticles and temperature-sensitive emitters, such as quantum dots. The plasmonic nanoparticle core is designed to efficiently produce localized heat upon excitation, which then interacts with an array of surrounding photosensitive emitters. The emitter uses two distinct excitation beams to allow for independent control of the excitations of the emitters and the heating of the core. By selectively filtering out the redshifted light, the ...

System and Method to Protect a Diver from Hazardous Energy Resulting from Underwater Powered Tools

JianlingL@tla.arizona.edu — Thu, 06 Feb 2025 14:20:51 GMT

This invention introduces a system and method to protect divers from hazardous energy when working with underwater powered tools, addressing the risks associated with power tool operations in underwater environments. It features an isolation manifold operated by a secondary diver to manage power flow to tools without needing to rely on verbal communication with topside support. The manifold integrates pressure relief mechanisms before and after a ball valve, ensuring that hazardous energy from pneumatic, hydraulic, or water-powered tools is safely controlled. The isolation of energy ensures th...

A Composite Index to Predict Subsequent Asthma with Clinical Data Obtained During the First Year of Life

JianlingL@tla.arizona.edu — Thu, 06 Feb 2025 14:15:26 GMT

This invention is a new index from a simple questionnaire that can predict with reasonable accuracy which children will develop asthma by 5-9 years of age. This involves a composite measure of symptoms of respiratory and non-respiratory illness collected in a research study on the first year of life in order to predict the development of childhood asthma. This index used in combination with parental history of asthma might provide a set of useful tools to predict which infants are at the highest risk for developing asthma by the time they are school age. Background: There is new researc...

Aggregate Size Estimator - AggSize

JianlingL@tla.arizona.edu — Thu, 06 Feb 2025 14:14:25 GMT

AggSize is an AI-powered mobile application designed to simplify and enhance rock size analysis for smaller mining sites. The technology processes captured images through a convolutional neural network (CNN) model to deliver accurate assessments of rock size distribution, a critical factor in mining quality control. By leveraging advanced neural networks and cloud-based computation, AggSize delivers results in real-time, complementing traditional laboratory tests. By providing immediate feedback, AggSize helps mining operators monitor and optimize production processes, enhancing efficiency and...

Incremental Software Architecture Reconstruction

JianlingL@tla.arizona.edu — Mon, 03 Feb 2025 08:29:43 GMT

This invention provides a solution for managing and analyzing the evolution of software architectures in systems built with microservices. It introduces an incremental approach to software architecture reconstruction, enabling continuous tracking and updating of system changes. This process creates a clear, up-to-date representation of how microservices interact, making it easier to identify potential issues, such as code conflicts or unintended ripple effects that can impact overall system performance. By focusing on "deltas," or changes between system versions, this technology help...

High Resolution Printing System with Large Field Optics and Related Process

JianlingL@tla.arizona.edu — Tue, 28 Jan 2025 10:11:33 GMT

This invention focuses on developing a high-throughput 3D printing system with multiple printheads, each equipped with a custom microscope objective that offers a field of view (FOV) five times larger than the commercial objectives used in current systems. The enhanced FOV allows for a significant increase in production throughput and efficiency compared to industry standards. By utilizing multiple printheads and a larger FOV, this system reduces production costs while streamlining the manufacturing process to enable faster printing cycles, reduced waste, and minimized operational complexity. ...

Compact Multimodal Imaging System with High Resolution Imaging and Widefield Imaging Modalities

JianlingL@tla.arizona.edu — Tue, 28 Jan 2025 10:10:40 GMT

This invention introduces a compact multimodal imaging probe that integrates high-resolution imaging modalities, such as confocal and multiphoton imaging, alongside widefield reflectance or fluorescence imaging. Unlike traditional methods that use a beamsplitter or dichroic mirror to combine the modalities, this approach places the imaging components side by side, reducing size while maintaining functionality. By carefully cutting away a small portion of the high-resolution system, space is created for the widefield imaging system without significantly impacting light efficiency. This design o...

A Method for Development of Alpha-Gal-Free Milk by using an Immobilized Alpha-Galactosidase

JianlingL@tla.arizona.edu — Tue, 28 Jan 2025 10:07:47 GMT

This invention addresses a growing need for alpha-gal-free milk, designed to aid individuals with Alpha-gal syndrome (AGS). AGS is triggered by the ingestion of alpha-galactose (aGal), a carbohydrate found in red meat and, in some cases, dairy products. While not all AGS patients react to dairy, avoiding its consumption completely is often recommended to prevent symptom progression. This method preprocesses milk using an enzyme to remove aGal effectively, resulting in a product suitable for AGS patients without sacrificing the nutritional benefits of milk. This innovative approach not only red...

3D Printed Glass Optical Elements with Controllable Local Transmission and Manufacturing Process

JianlingL@tla.arizona.edu — Tue, 21 Jan 2025 08:19:46 GMT

This invention is a method for fabricating complex 3D printed glass microstructures with controllable local transparency, targeting applications such as optical lens design and advanced optical components. It uses polymeric silsesquioxane (PSQ) and two-photon polymerization (TPP) to tune transparency levels by manipulating parameters like laser power, scanning speed, part thickness, and pyrolysis heating rate. This technique enables the creation of multi-transparency glass micro-objects with high precision, providing a scalable solution for integrating varying transparency regions into a singl...

Composite Filament for 3D Printing of Resorbable Bone Scaffolds

JianlingL@tla.arizona.edu — Thu, 16 Jan 2025 15:56:44 GMT

This innovation is composite filaments for 3D printing bioresorbable scaffolds for surgical implantation. These filaments typically have high strength, an appropriate resorption rate, and high biocompatibility. The resulting scaffolds offer customizable shapes and resorption rates. The improvement in this innovation compromises a bone volume fraction (BV/TV) of the implanted PBT, PLA, and composite ceramic polymer biomimetic scaffolds. Furthermore, the bone volume (mm3) demonstrates that the composite ceramic scaffolds support more bone growth into the scaffold than pure PBT or PLA. Backgrou...

Endoglin Antibody

JianlingL@tla.arizona.edu — Thu, 16 Jan 2025 07:38:12 GMT

This technology is the use of endoglin-specific antibodies to enhance the detection process of certain cancers, offering a more precise and reliable approach to identifying cancer-related variants of endoglin. Directed toward an antibody to a mutated endoglin protein, this antibody provides methods and compositions for detecting splice variants of the endoglin protein, enabling the accurate diagnosis of cancer. Background: According to the American Cancer Society, as of 2025, pancreatic cancer accounts for about 3% of all cancers in the United States and about 7% of all cancer deaths. T...

Cultured Cells Lifting/Cryopreservation Efficiency Training Program

JianlingL@tla.arizona.edu — Mon, 13 Jan 2025 09:07:05 GMT

This is an innovative spreadsheet-based method designed to improve the efficiency of training and evaluation for cultured cell lifting and cryopreservation procedures. It is part of a comprehensive training program aimed at streamlining skill acquisition in cell culture labs. Unlike traditional methods, where training outcomes are evaluated broadly based on overall experimental results, this system introduces stepwise, quantifiable criteria that pinpoint specific skill areas for improvement. The spreadsheet automatically calculates and evaluates key performance metrics, eliminating the need fo...

Incubator Microplate Rack

JianlingL@tla.arizona.edu — Mon, 13 Jan 2025 08:27:55 GMT

This invention is a specialized incubator rack system designed to optimize cell culture in microplates by providing uniform growth conditions (equal airflow, humidity, and thermal conditions) for all plates regardless of their position in the stack. This rack ensures consistent growth conditions for cells compared to traditional incubator practices where plates are often directly stacked, potentially affecting the growth consistency of cultured cells. Background: In laboratory settings, cell cultures are commonly grown in microplates that are placed directly in incubators. Reducing plat...

Petahertz Phototransistor

JianlingL@tla.arizona.edu — Fri, 10 Jan 2025 14:03:52 GMT

The novel petahertz phototransistor represents a significant breakthrough in computational technology by harnessing optical approaches to achieve unprecedented switching speeds. As the limitations of traditional transistor-based computing become more apparent, particularly in reaching gigahertz speeds, this innovation offers a promising alternative. By leveraging a hybrid optoelectronic device, which integrates optical and electronic components, the invention demonstrates petahertz switching capabilities. What sets this invention apart is its ability to achieve improved performance using off-t...

A Method to Increase the Solubility of the Flavonoid Rutin for Biological Assays and Administration for Protective Effects

JianlingL@tla.arizona.edu — Thu, 09 Jan 2025 13:25:52 GMT

This technology is an improved method for maximizing the solubility of the flavonoid rutin to effectively protect bees against the harmful effects of fipronil and deltamethrin, two types of commonly used pesticides. This technology serves as a non-toxic alternative to the current method of rutin dissolution, and has no physiological or cognitive side effects on the honeybees themselves. Notably, this method offers a promising approach for enhancing the bioavailability of rutin, potentially amplifying its therapeutic and protective benefits. Background: Flavonoids are nutraceutical molec...

Cancer treatment through hTERT inhibition

JianlingL@tla.arizona.edu — Tue, 07 Jan 2025 16:11:50 GMT

Title: Cancer Treatment Through hTERT Inhibition Invention: The invention is a small molecule that reduces human telomerase reverse transcriptase (hTERT), which is highly activated in cancer cells. Background: In 2010, approximately 73,599 U.S. patients were diagnosed with melanoma with 8,700 of those incidences resulting in death. A hallmark of cancer, and melanoma specifically, overexpression of hTERT results in cell immortalization. These types of tumors have transcription-activating mutations in the hTERT promoter region because of a pair of G-quadruplexes. The small molecule binds selecti...

Chimetic Antigen Receptor (CAR)-Stem Cells (MSCs) and its use for Cardiovascular Diseases

JianlingL@tla.arizona.edu — Tue, 07 Jan 2025 16:10:31 GMT

This technology describes Chimetic Antigen Receptor (CAR) mesenchymal stem cells (MSCs) and their use in treatment of cardiovascular diseases. This technology will use engineered MSCs capable of homing toward infarcted heart tissue. Background: Cardiovascular disease is the leading cause of death in the United States. There are multiple treatments and strategies to prevent heart disease. Many of these are ineffective as incidence of heart disease has increased. MSCs have been studied as a potential treatment but have shortcomings that need to be addressed: short survival, bill...

Inflatable Habitat Zipper Enclosure

JianlingL@tla.arizona.edu — Mon, 06 Jan 2025 10:57:00 GMT

This invention describes an inflatable shelter concept for lunar and Martian surface missions. The design features a lightweight, inflatable structure that employs a dual airtight zipper door enclosure to maintain a pressure-safe atmosphere for astronauts. This zipper mechanism, inspired by spacesuit designs, allows astronauts to seal and access the habitat from either inside or outside, addressing a critical gap in current emergency habitat technology. This allows for operation from both sides and includes a locking mechanism to prevent accidental depressurization. The shelter is compact enou...

Surrogate β-cell Production for Cell Therapy

JianlingL@tla.arizona.edu — Mon, 06 Jan 2025 10:12:33 GMT

This innovative cell therapy treatment for Diabetes Mellitus is designed to create surrogate β-cells that release insulin in response to physiological increases in blood glucose levels, mimicking the natural function of pancreatic cells. These modified cells are then used in macro or microencapsulation devices, which provide a controlled environment for the cells, allowing for sustained and regulated insulin release. Additionally, the encapsulation devices protect the cells from the body’s immune response while allowing them to function effectively. This solution not only offers a p...

Synthesizing Disease-Associated Scents as Diagnostic Tools to Enhance Healthcare Education and Healthcare Delivery: A One-Health Project

JianlingL@tla.arizona.edu — Mon, 06 Jan 2025 08:05:16 GMT

Body odors can be thought of as olfactory “fingerprints” related to health. Each characteristic scent of disease stems from emission of key volatile and semi-volatile organic compounds (VOCs) in breath, sweat, urine, skin, blood, milk, feces, and/or other secretions. Incorporating these scent profiles into educational tools, such as teaching modules and manikins, can enhance veterinary clinical skills programs. By integrating this technology into veterinary medical education, students across human medical, veterinary medical, nursing schools, and veterinary technician progra...

HLA-C Single Chain Trimers to Prevent Natural Killer Cell-Mediated Rejection

JianlingL@tla.arizona.edu — Fri, 20 Dec 2024 09:20:46 GMT

This invention is for a method of genetic modification of major histocompatibility complex (MCH) component for prevention of natural killer (NK) cell recognition of pluripotent stem cell grafts using HLA-C trimers. This new method works to overcome immunological rejection by the recipient via genetic modification of these cells. Background: As of 2020, there were more than 3,000 trials involving the use of adult stem cells registered in WHO International Clinical Trials Registry. Induced pluripotent stem cell therapy is a novel medical therapy that utilizes donor embryonic stem cells ca...

Rescue Spacesuit

JianlingL@tla.arizona.edu — Mon, 16 Dec 2024 11:05:48 GMT

The Rescue Spacesuit is an innovative advancement designed to enhance astronaut safety during space exploration and extraterrestrial missions. The spacesuit has integrated c-spine support and tourniquets on the arms and legs. There are inflatable aspects integrated in the spacesuit to support these two functions. The c-spine support system, deployable via inflation, provides traction to stabilize the head and neck of an injured astronaut. The c-spine support can be activated using internal suit gas or external sources, while the limb tourniquets are strategically placed atop the bladder layer ...

Custom Coded Raspberry Pi Pico to Induce Atrial Fibrillation in Swine

JianlingL@tla.arizona.edu — Mon, 16 Dec 2024 11:03:45 GMT

This invention is a low cost, reproduceable device designed to reproduce atrial fibrillation (AFib) in swine to create a large animal model of persistent AFib. Using a Raspberry Pi Pico microcontroller to burst pace, this device allows for more modularity and can be programmed with many common programming languages. This large animal model can help researchers understand the mechanism of persistent AFib and develop and test new treatments, medications, ablation, and cell-based therapy. Background: Atrial fibrillation (AFib) is the most common arrhythmia in adults in the US and is ...

Design of Quasi-Cyclic Lifted Product Quantum LDPC Codes

JianlingL@tla.arizona.edu — Mon, 16 Dec 2024 11:03:02 GMT

Quantum low-density parity-check (QLDPC) codes are the leading candidate for performing error correction in scalable fault-tolerant quantum computing systems. This invention presents a method for designing quasi-cyclic lifted-product QLDPC codes to enhance error correction performance in quantum systems, such as quantum computing, communication, and storage. This design makes it possible to create LP-QLDPC codes that ensure a minimum distance strictly greater than that of the lowest-weight stabilizer generators, which achieves superior error correction. By focusing on quasi-cyclic base codes, ...

Two-bit Bit Flipping Decoder Diversity for Quantum LDPC Codes

JianlingL@tla.arizona.edu — Mon, 16 Dec 2024 11:02:14 GMT

Quantum low-density parity-check (QLDPC) codes are the leading candidate for performing error correction in scalable fault-tolerant quantum computing systems. This invention presents a Two-bit Bit Flipping Decoder Diversity (TBF) for quantum low-density parity-check (QLDPC) codes, specifically targeting variable degree-3 QLDPC codes. By using a refined two-bit bit-flipping technique, this decoder improves error correction performance and reduces latency, which are critical for quantum applications. The approach is designed to handle complex configurations, such as trapping sets in hypergraph p...

Placement of Spinal Cord Stimulation Leads

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:41:09 GMT

This technology focuses on improving spinal cord stimulation (SCS) treatments by helping physicians determine the optimal placement of stimulation leads on the body. The approach utilizes a specialized algorithm designed to predict the best lead locations for achieving effective pain relief and improved clinical outcomes. By integrating advanced imaging and electrophysiological modeling, the system provides tailored recommendations based on individual patient anatomy and physiology. The technology employs an MR-based electrophysiological model to simulate and analyze potential lead placements....

Multi-Modality Machine Learning for Pain Outcomes

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:40:37 GMT

Chronic pain affects millions of people, making it a challenging condition to effectively manage. Traditional methods of assessing and treating pain rely heavily on subjective measures, which can lack accuracy and sensitivity. As a result, there is a growing need for objective tools to assess chronic pain and improve treatment outcomes. EEG (electroencephalography) has emerged as a promising option, offering a noninvasive, portable way to measure brain activity and capture real time changes related to pain perception. EEG's high temporal resolution allows for tracking rapid changes in brai...

Scheduling Architectures for Distributed Observation Systems

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:38:38 GMT

This technology is an advanced coordination and scheduling system designed to monitor, track, and predict the motion of distributed objects in various domains, such as air, space, and underwater, through vision-based techniques. The architecture utilizes advanced scheduling systems that assign operational tasks to camera arrays for continuous observation. The schedulers are designed to control an array of multiple camera and computer units to track many moving objects simultaneously. This system continuously prioritizes tasks and assigns cameras to specific tracking goals as new objects are en...

Thin Film Optical Coating-Based Photonic Accelerators for Scalable and CMOS-Integrated Matrix-Vector Multiplication

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:37:32 GMT

This technology introduces a photonic accelerator platform for faster, more efficient computing using advanced optical coatings integrated with existing camera technology. It leverages thin film optical coatings (TFOCs) to perform matrix-vector multiplication (MVM). The system integrates these TFOCs with CMOS technology, a standard in microelectronics, to overcome scalability and compatibility challenges in current photonic computing techniques. It allows calculations to be performed with high precision and speed while being energy-efficient and cost-effective. This approach simplifies integra...

Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:35:18 GMT

The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and other devices to efficiently gather data. It prioritizes observations based on their location and urgency, and it can automatically adjust to new requests in real time. The system is optimized to keep the camera in operation as much as possible, o...

Planner – Planning Software for Near-Earth Object Survey Operations

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:35:09 GMT

The Planner subsystem in the Catalina Sky Survey (CSS) software suite is designed to help observers efficiently plan nightly asteroid and Near-Earth Object (NEO) observations. By displaying a virtual map of the sky, it helps ensure that areas previously searched, or areas unlikely to be productive, are avoided. The map shows the telescope’s current position and highlights objects requiring additional observations to improve orbit accuracy. It also indicates potential interference, such as the Moon or the Milky Way, and incorporates data from sources like the Minor Planet Center (MPC) and...

Processing – Software to Process and Analyze Images for NEO Survey

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:34:58 GMT

The Processing subsystem in the Catalina Sky Survey (CSS) software suite is a streamlined pipeline designed to handle raw images captured by telescopes during asteroid and Near-Earth Object (NEO) surveys. This pipeline processes the images through multiple stages, such as calibrating for optical distortions, extracting star or asteroid positions, and converting these positions into standard astronomical coordinates. By automating the process, the system allows multiple operations to occur simultaneously, improving efficiency and speeding up data analysis. The CSS pipeline incorporates widely u...

Monitor – Software to Monitor Status of New and Recently Discovered Objects for NEO Survey

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:34:47 GMT

The Monitor subsystem in the Catalina Sky Survey (CSS) software suite is designed to help track the status of newly discovered and recently observed asteroids and Near-Earth Objects (NEOs). It gathers data from various public sources, such as the Minor Planet Center and other NEO survey programs, to provide a clear and prioritized summary of which objects require further observation. This allows CSS observers to focus on the most important objects, ensuring efficient use of resources and reducing the risk of missing significant discoveries. The system displays this information on an internal w...

Control - An Executive Program for Near-Earth Object Survey Operations

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:32:24 GMT

The Catalina Sky Survey (CSS) software suite is designed to detect and track Near-Earth Objects (NEOs), such as asteroids, that may pose a collision risk with Earth. By coordinating observations and data processing through multiple subsystems, the suite enables accurate tracking of these objects. The software manages telescope operations, image acquisition, and data analysis, culminating in the calculation of asteroid orbits and sizes. This information is shared with the Minor Planet Center (MPC) to facilitate global research and collaboration. A key component of CSS is its “Control&rdqu...

Photopolymerization of Disulfide Methacrylate Resin

JianlingL@tla.arizona.edu — Mon, 09 Dec 2024 11:29:59 GMT

This technology introduces a disulfide methacrylate resin designed for high-performance optical applications. Utilizing a novel photopolymerization process, this resin offers enhanced optical properties, such as a high refractive index and low birefringence, making it suitable for precision optics, 3D printing, and advanced manufacturing. The material’s disulfide bonds allow for rapid curing under UV light, making sure of high durability and stability for applications that require both mechanical strength and optical clarity. The resin’s rapid free-radical photopolymerization enabl...

Factor XII(a) is a Biotarget for Treatment of Dilated Cardiomyopathy and Heart Failure

JianlingL@tla.arizona.edu — Wed, 04 Dec 2024 10:06:00 GMT

Researchers at the University of Arizona have identified a novel, previously unrecognized harmful role of coagulation factor, Factor XII (FXII) and/or activated coagulation factor XIIa (fXII(a)) in modulating the progression of dilated cardiomyopathy and heart failure development. They have proposed fXII(a) as a new biotarget to treat dilated cardiomyopathy or heart failure. Background: Approximately 6.2 million Americans and 64.3 million people worldwide currently have heart failure, and those numbers are expected to grow 50% by 2035. Techniques (new or repurposed) that suppress fXII(a...

Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D2O

JianlingL@tla.arizona.edu — Wed, 04 Dec 2024 09:48:44 GMT

This technology presents an organophotocatalytic method for selective deuteration of metabolically labile α-positions in amides, amines, and secondary alcohols. This approach achieves high regioselectivity and deuterium incorporation by masking secondary amines as carbamates and employing a photoredox-HAT (hydrogen atom transfer) process. This innovation allows for efficient H/D exchange in complex pharmaceutical structures, including piperidine and piperazine, which are critical for enhancing drug stability and reducing metabolic degradation. Background: Current methods for...

Improving Sleep via Suppression of Default Mode Connectivity with Continuous Theta Burst Stimulation

JianlingL@tla.arizona.edu — Wed, 04 Dec 2024 08:10:49 GMT

This technology involves the use of transcranial brain stimulation to induce sleep and has the potential to be an effective non-pharmacological approach for treating insomnia and improving sleep quantity and quality. Specifically, the technology targets the Default Mode Network (DMN) through Continuous Theta Burst stimulation, which has been shown to reduce neural activity in the part of the brain responsible for daydreaming and rumination, ultimately leading to a reduction in sleep onset time. Background: According to the American Academy of Sleep Medicine, 30-35% of adults have brief ...

Creating Photonic Metamaterials in CMOS Foundry Processes

JianlingL@tla.arizona.edu — Tue, 03 Dec 2024 13:56:36 GMT

This invention focuses on creating photonic metamaterials by repurposing CMOS (Complementary Metal-Oxide-Semiconductor) foundry processes. Metamaterials are engineered structures designed to achieve specific electromagnetic properties, enabling unique effects such as negative refraction, superlensing, and enhanced light-matter interaction. This development uses advanced 3D nanofabrication in semiconductor foundries to produce metamaterials with exotic properties, like zero and negative refractive indices and hyperbolic characteristics. Background: Metamaterials are specialized artificia...

Autonomous Soaring Method for Harnessing, Accumulation, and Release of Atmospheric Energy

JianlingL@tla.arizona.edu — Tue, 03 Dec 2024 13:55:01 GMT

This technology is a dynamic soaring method for unmanned aerial vehicle (UAV) application. This dynamic soaring method consists of a novel set of maneuvers to enhance efficiency in long-distance UAV flights in the presence of unsteady winds. By using maneuvers following elliptical and helical trajectories through winds to harness maximal atmospheric energy, UAVs can autonomously exploit atmospheric energy, resulting in longer mission durations with reduced reliance on onboard power sources. These maneuvers can be integrated into existing UAV autopilot systems to achieve more optimal flight pat...

Colorectal Cancer Prognostic/Prediction

JianlingL@tla.arizona.edu — Tue, 03 Dec 2024 13:53:02 GMT

This technology provides a gene score system to assess the effectiveness of antifibrotic treatments on colorectal cancer (CRC). By comparing gene expressions from colorectal cancer cells under two different types of mechanical conditioning, this system identifies specific gene signatures that correlate with an increased risk of metastasis and lower survival rates. The gene score can be used to help determine whether patients with colorectal cancer should undergo additional preventative therapies to reduce the risk of metastasis. Additionally, the system involves in vitro analysis of colorectal...

Diagnostic for Non-Invasive Screening and Early Detection of Adenomyosis and/or Endometriosis using Urine

JianlingL@tla.arizona.edu — Tue, 03 Dec 2024 13:50:51 GMT

Adenomyosis and endometriosis, both gynecological conditions, lack clear diagnostic guidelines, making early detection and treatment challenging. Current efforts by University of Arizona researchers are focused on addressing this gap, aiming to develop a non-invasive method for detecting adenomyosis and endometriosis, and possible related causes of infertility. Preliminary studies have shown that urine sampling could detect disease related metabolites and proteins to be used as candidate biomarkers in the cervicovaginal environment for a non-invasive adenomyosis and endometriosis diagnostic. T...

Vortex Liftoff and its Flutter Effect on Swept Back Wings

JianlingL@tla.arizona.edu — Tue, 03 Dec 2024 09:20:06 GMT

This invention involves swept back wings that use Leading-Edge Vortex (LEV) for more controlled improvements of fixed wing aircraft. The technology enables a greater lift force and better aeronautical stability. Additional testing has shown that introducing a crank or a protuberance in the leading edge can initiate the process of vortex liftoff at lower incidence angles, expanding the operational range of the wing before stall conditions are met. Moreover, the use of a high-speed, small jet has demonstrated the potential to delay the vortex liftoff and alter its trajectory, thereby mitigating ...

Damped Flexure Mount

JianlingL@tla.arizona.edu — Tue, 03 Dec 2024 09:12:42 GMT

The invention is a dampened flexure mount capable of enhancing the vibration isolation of highly sensitive equipment, including optics, aerospace, and space applications. The mount’s improved dampening capability arises from the incorporation of two or more materials in its design, where one imparts rigidity, while the other imparts flex dampening properties. The design adopts the concept of constrained layer damping. Here, a viscoelastic material is sandwiched between the mount and a rigid constraining layer. Vibrational energy, instead of adversely impacting the equipment, causes shear...

A Method for Performing Permutation Operations using Phi-Bits (Acoustic Analogues of Qubits)

JianlingL@tla.arizona.edu — Mon, 25 Nov 2024 14:19:51 GMT

This invention consists of methods for obtaining all possible permutations using logical phi-bits, which are classical analogues of quantum bit (qubits) and are supported by driven acoustic metamaterials. Permutation operations are essential in quantum computing as they enable the manipulation of quantum states through fundamental gates. The method addresses all possible permutations of a four-component state vector describing the state of logical phi-bits in a complex Hilbert space, as well as a scalable inversion operation. These permutations are performed with a single physical action on th...

A Method for Encoding, Encrypting and Decrypting Information using Phi-Bits (Acoustic Analogues of Qubits)

JianlingL@tla.arizona.edu — Mon, 25 Nov 2024 14:19:36 GMT

This invention addresses the need for robust data security in the face of emerging quantum computing risks and presents logical phi-bits as a promising solution for encryption in the digital age. This cryptography method uses logical phi-bits, which are classical analogues of quantum bits (qubits) and are supported by driven acoustic metamaterials. The state of phi-bits displays superpositions similar to quantum bits, with complex amplitudes and phases. This can strengthen data security at speeds and scales comparable to quantum information modalities without suffering from the fragility inher...

Damage Localization in Plate Structures using the Geometric Phase of Acoustic Waves

JianlingL@tla.arizona.edu — Mon, 25 Nov 2024 14:18:21 GMT

This technology is a novel non-destructive testing and evaluation (NDT&E) method designed to locate defects and damages in plate structures. While traditional defect localization techniques analyze velocity differences or amplitude ratio, this technology’s topological acoustic approach analyzes changes in the geometric phase of acoustic waves as they pass through a medium. By considering a subset of sensors and calculating a geometric phase change index (GPC-I) along various paths, the invention achieves more precise defect localization. This method is ideal for detecting defects in ...

App for Interfacing with RFID Implantable Medical Devices

JianlingL@tla.arizona.edu — Mon, 25 Nov 2024 14:15:20 GMT

This innovative technology leverages a Bluetooth Low Energy (BLE) app to facilitate communication between an RFID controller and wireless, battery-free implantable medical devices. Designed for departmental research use, the app allows seamless data exchange with the implantable devices, enabling real-time monitoring and validation of data transmission. The processed data is then displayed in near real-time, allowing researchers to quickly assess the functionality and reliability of the data link, enhancing the efficiency and accuracy of medical device research. Background: The technolo...

Weefly

JianlingL@tla.arizona.edu — Mon, 18 Nov 2024 08:22:42 GMT

The Weefly device is a reusable, cleanable urinary aid designed to allow individuals with female anatomy to urinate comfortably while sitting or standing in various environments, such as aircraft, spacecraft, automobiles, trains, and more. Weefly is designed with flexibility and hygiene in mind, featuring a secure docking mechanism that uses adhesives or a garment to maintain a watertight seal, ensuring the device stays in place during use. Ideal for extreme conditions and professions requiring long hours without access to restrooms, such as pilots, astronauts, and race car drivers, Weefly off...

Ultrafast Pump-Multi Probe Imaging System

JianlingL@tla.arizona.edu — Mon, 18 Nov 2024 08:12:26 GMT

This technology is a pump-probe imaging system designed to capture a sequence of events, even in non-repetitive processes, by employing a light field synthesizer. The system leverages the light field synthesizer to convert a single probe pulse into a train of temporally separated pulses, each with a distinct wavelength range. These pulses interact with a sample at different time delays, capturing multiple snapshots of the event's progression in a single measurement with high precision. These time delays can be adjusted by the user to optimally capture different types of events. This imagin...

Time-Varying Photonics and Quantum Light Source Using High Temporal Resolution and Repetition Rate Laser Pulses

JianlingL@tla.arizona.edu — Mon, 18 Nov 2024 08:10:16 GMT

This technology is a step towards achieving time-varying photonics at optical (visible and IR) wavelengths. It functions by utilizing ultrashort pulses, shorter than ten femtoseconds, to modulate the reflectivity of a material at optical frequencies greater than 100 THz. The modulation rate can be tuned for different purposes, as both the pulse repetition rates and interpulse delay times are adjustable. This modulation creates an environment in which entangled proton pairs can be generated via the dynamic Casimir effect. Furthermore, the high temporal resolution and high repetition rate of thi...

3D Rendering and Endoscope Tracking Software for Virtual Reality Surgical Training System with Haptic Feedback

JianlingL@tla.arizona.edu — Sat, 09 Nov 2024 14:08:06 GMT

This invention provides medical students and professionals the ability to practice surgical techniques in virtual reality with true haptic feedback. This technology is currently designed for otolaryngology procedures where users are provided with a virtual reality headset and imitation medical tools for operating on a tangible model head. Background: Typically, medical students are able to practice surgical techniques on a cadaver one time during their education. While this is helpful, students would benefit from being able to practice their surgical procedures multiple times throug...

Room Scale Virtual/Hybrid Reality Endoscopic Surgery Simulation System Using and Synchronized Patient-Specific Anatomy Virtual and Physical Models

JianlingL@tla.arizona.edu — Sat, 09 Nov 2024 14:07:33 GMT

Endoscope With Haptic Feedback and VR Controllers for Virtual Reality Surgical Training System

JianlingL@tla.arizona.edu — Sat, 09 Nov 2024 14:07:11 GMT

Method and Device for Imaging and Ranging through Optical Fibers

JianlingL@tla.arizona.edu — Thu, 07 Nov 2024 10:26:49 GMT

This invention is a novel method and device for imaging and ranging through various types of optical fibers, including multi-mode and multi-core fibers. This technique allows for depth measurements and imaging without needing prior knowledge of the scene or the fiber's transmission matrix. By generating a “synthetic wavefront” through the computational combination of two wave fields at slightly different wavelengths, the method counteracts the phase scrambling effects that typically occur during light transmission through optical fibers. This approach offers tunable depth and l...

ENT1 and ENT2 Functional Knockout HeLa Cell Lines

JianlingL@tla.arizona.edu — Wed, 06 Nov 2024 09:16:12 GMT

This invention operates by utilizing equilibrative nucleoside transporter (ENT) proteins for the study of cellular processes and other varieties of pharmacological research. Researchers at the University of Arizona have developed ENT1 and ENT2 functional knockout cell lines that lack the ability to transport nucleosides normally, which can be useful for studying the role of these transporters in cellular processes or for testing the effects of drugs that interact with them. Background: Equilibrium nucleoside transporter proteins reside in the cellular membrane of a variety of tiss...

Organ-on-Chip Apparatus for Quantitative Study of Cellular Interaction with Ultrasound

JianlingL@tla.arizona.edu — Wed, 06 Nov 2024 09:09:59 GMT

This is an organ-to-chip device that is constructed by using thin membranes. The device allows quantitative in vitro modeling of cellular interactions by using ultrasound. The technology also has a large potential for therapeutic applications for treating different diseases. The flexibility of organ-on-chip technologies is a great tool to help speed up drug development processes and could assist in possibilities for personalized medicine. Organ-on-chip technologies will also allow researchers to view the organ’s functionality, behavior, and response on a cellular and molecular level. Ba...

SPINE (Shared Processing Infrastructure for NLP Ecosystems)

JianlingL@tla.arizona.edu — Mon, 04 Nov 2024 11:34:27 GMT

Shared Processing Infrastructure for NLP Ecosystems (SPINE) is an innovative software platform designed to optimize the deployment of large language models (LLMs) within enterprise environments. The platform leverages existing hardware resources within the organization to help businesses adopt a large language model to their workflows while protecting the company’s sensitive intellectual property. SPINE can optimize performance for large-scale operations, has real-time compliance and auditing features, incorporates bias detection mechanisms and ethical AI practices, and provides robust r...

Adaptive Network Intelligence Agent with Dynamic Host Reassignment

JianlingL@tla.arizona.edu — Mon, 04 Nov 2024 11:33:42 GMT

The Adaptive Network Intelligence Agent with Dynamic Host Reassignment (DaRIA) is a cutting-edge cybersecurity tool designed to enhance intelligence collection capabilities across multiple platforms. This innovative system allows law enforcement and federal agencies to efficiently gather system-level intelligence on computer-based targets in real time. By dynamically reassigning hosts, DaRIA adapts to evolving threats, ensuring continuous monitoring and data collection without detection. The technology's flexibility across different operating systems and its integration with offensive cybe...

GRID-LM: an AI-Powered Distributed Model for Infrastructure Threat Detection and Response

JianlingL@tla.arizona.edu — Mon, 04 Nov 2024 11:33:02 GMT

GRID-LM is an advanced, AI-powered distributed model designed for Operational Technology (OT) network security monitoring, infrastructure threat detection, and response. By leveraging machine learning, GRID-LM can detect deviations from established baselines, helping organizations identify and respond to potential threats before they impact operations. By leveraging distributed resources within a local-based environment, GRID-LM aims to provide near-real-time threat detection and responses to enhance security around sensitive data and systems, ultimately providing a sophisticated layer of prot...

Scalable Grayscale Lithography on Any Material through Reactive Ion Etching

JianlingL@tla.arizona.edu — Mon, 04 Nov 2024 08:32:17 GMT

This invention is a new approach to grayscale lithography, enabling the direct fabrication of 3D features on a variety of materials without the need for photoresists. By leveraging two effects during reactive ion etching (RIE), the process provides precise control over the depth and profile of etched features, making it highly versatile for applications on optical and other substrates. Unlike conventional lithographic methods, which are often material-limited and less scalable, this technology expands the possibilities for etching complex structures on a broader range of surfaces. Key benefits...

Engineering of piRNA Generating Synthetic RNAs for Greater Stability and Subcellular Targeting

JianlingL@tla.arizona.edu — Mon, 04 Nov 2024 08:30:29 GMT

This invention is for a novel bioinsecticide for use in combatting Bemisia tabaci B mitotype NAF-ME cryptic species, the whitefly pest. This new method utilizes piRNA gene splicing techniques to incite lethal phenotypes into the target with increased targeting and specificity for use in other mechanisms. Background: RNAi technology falls under the plant-incorporated protectant (PIP) category. Before the first PIP product was registered in 1995, EPA required that PIP products be thoroughly tested to ensure they meet federal safety standards before they were used on human food and livesto...

Use of Waste Heat to Produce Potable Water

JianlingL@tla.arizona.edu — Mon, 04 Nov 2024 08:29:10 GMT

This invention introduces an advanced energy-efficient membrane bioreactor-membrane distillation (MBR-MD) system designed to change wastewater treatment and reuse. By combining biological treatment with membrane distillation, this technology guarantees high-quality water reuse while significantly cutting energy use. Unlike conventional systems that rely on membrane bioreactors followed by reverse osmosis (MBR-RO), which require large amounts of electrical energy and create brine waste, this MBR-MD system eliminates brine waste and runs on much lower energy levels. It offers a sustainable solut...

Tools And Techniques To Identify Antigen-Specific T Cells

JianlingL@tla.arizona.edu — Fri, 01 Nov 2024 14:57:45 GMT

This invention is a new tool and technique for identification of antigen-specific t cells. By using specific molecules from specified cell lines as antigen presenting cells, the identified T cells are labeled with different fluorescence. These cells go through the flow cytometry and the flow cytometry data is analyzed by a specific assay designed by the inventor to identify the antigen-specific T cells. The new tool and approach can detect these antigen specific T-cells with TCR affinity lower than closest known products. Background: T cells are essential for long-lived, protective immunity a...

Medication Education, Decision Support, Reminding and Monitoring System - Memory (MEDSReM-M)

JianlingL@tla.arizona.edu — Tue, 29 Oct 2024 15:13:49 GMT

Medication Education, Decision Support, Reminding and Monitoring System - Memory (MEDSReM-M) is an interactive application designed to help older adults manage their medications more effectively and support adherence. It builds on an existing theory-based mobile health system, adapting it to create a user-friendly tool for those who need extra support remembering to take their medications as prescribed. The app aids people with memory issues, such as mild cognitive impairment, by simplifying the medication management process and integrating features that enhance memory and adherence. Developed...

Creation of Diffractive Lenses and Fresnel Zone Plates in Semiconductor Processes and their use for Spectral Filtering

JianlingL@tla.arizona.edu — Tue, 22 Oct 2024 15:15:42 GMT

This invention focuses on incorporating diffractive optical elements, like a Fresnel zone plate, into the semiconductor fabrication process, particularly in the back-end-of-line (BEOL) stage. By doing so, it enhances the functionality of semiconductor devices by enabling advanced imaging and spectroscopic capabilities directly on the chip. This approach is cost-effective and scalable, compatible with existing fabrication techniques, and can be applied to a wide range of fields including biomedical imaging, optical communications, and remote sensing. A key feature of this technology is its abil...

Metasurface-Based Spatial Mode Demultiplexer for Enhanced Imaging Resolution

JianlingL@tla.arizona.edu — Tue, 22 Oct 2024 15:15:03 GMT

This invention introduces a compact and lightweight system designed to enhance imaging resolution using a metasurface-based spatial mode demultiplexer. It utilizes a specially engineered metasurface that can efficiently sort and detect the first few orders of spatial modes of light, which are then projected onto a high-resolution camera or detector array. By separating these spatial modes, the system improves the resolution of imaging devices, allowing for the capture of fine details that surpass the diffraction limit of traditional imaging systems. The sorted spatial modes' amplitudes are...

Metasurface Faraday Isolator

JianlingL@tla.arizona.edu — Tue, 22 Oct 2024 15:14:09 GMT

This technology is an ultrathin Faraday isolator that incorporates two novel features that enhance its electromagnetic isolation capability. The first is the incorporation of highly polarization-sensitive metasurfaces to allow it to achieve the necessary polarization rotation for isolation in relatively weak magnetic fields. The second is the usage of ultrathin magneto-optical material with a thickness of only a few microns, making the device much thinner than traditional Faraday isolators. This design minimizes polarization rotation and operates with weak magnetic fields, making it ideal for ...

Stainless Brush Biopsy for Epithelial Cells

JianlingL@tla.arizona.edu — Mon, 21 Oct 2024 10:03:49 GMT

This invention is a new approach to cervical cancer screening that removes the need for staining cervical specimens, leading to significant time and cost savings. Using a brush biopsy technique to collect cells from all layers of the cervix using a specialized brush, the specimen is spread on a slide and imaged using deep ultraviolet (dUVM) technology. This image is then analyzed for the presence of cervical cancer. By cutting out the need for complex sample transportation and laboratory processing, this method streamlines the entire screening process, allowing patients to receive accurate tes...

Food Demonstration Guide

JianlingL@tla.arizona.edu — Wed, 09 Oct 2024 11:05:34 GMT

The Food Demonstration Guide is a comprehensive resource developed to enhance the quality and safety of food demonstrations conducted under the Arizona Department of Health Services' Supplemental Nutrition Assistance Program Education (SNAP-Ed) and Women, Infants, and Children (WIC) programs. This guide aims to train SNAP-Ed and WIC staff on best practices for preparing, presenting, and storing food during demonstrations. It emphasizes food safety protocols to prevent contamination and ensure the health and well-being of participants. Background: Food safety, nutrition, and fo...

Crowd-Sourced Traffic Speed Module

JianlingL@tla.arizona.edu — Wed, 09 Oct 2024 11:05:02 GMT

The Crowd-Sourced Traffic Speed Module is one of the many fundamental components of high-performance statewide transportation analytics and visualizations tools. This new tool, using crowdsourced vehicle speed data, allows agencies and organizations to make informed decisions with comprehensive vehicle data on a state-wide level for a safer, more efficient transportation infrastructure. Through an interactive state map, transportation agencies can define their analysis parameters to gain detailed insights into traffic patterns, road safety, and overall transportation efficiency. The Crowd-Sour...

Antibody Therapy and Diagnosis for Microsporidiosis Disease in Shrimp Aquaculture

JianlingL@tla.arizona.edu — Thu, 03 Oct 2024 14:21:42 GMT

This invention is a therapy against Ecytonucleospora hepatopenaei (EHP) and diagnostic method to identify EHP-infected shrimp using monoclonal antibodies. The antibodies can be produced in cell culture or expressed using a heterologous expression system for administering to shrimp broodstock, post larvae in a hatchery, and in farmed shrimp in a grow out pond and/or raceway as a preventative or therapeutic measure. Additionally, it can be delivered via shrimp feed or directly to the shrimp. Background: Hepatopancreatic microsporidiosis, caused by Ecytonucleospora hepatopenaei...

Generation of Heat-Tolerant Pollen Tubes in Arabidopsis

JianlingL@tla.arizona.edu — Thu, 03 Oct 2024 14:18:18 GMT

This innovation is a method of genetically editing molecular mechanisms of economically important fruit crop plants, such as tomatoes, to create reproductively heat-tolerant crops. This new method involves manipulation of pollen tubes to improve the response of plants to various climate stressors. Background: Since early 2020, the U.S. Southwest has been experiencing one of the most severe long-term droughts of the past 1,200 years. Multiple seasons of record low precipitation and near-record high temperatures were the main triggers of the drought. Climate projections to the year 2100 s...

Transparent Highly Ce3+-doped Boron-Aluminosilicate Glass for Advanced Photonic Applications

JianlingL@tla.arizona.edu — Thu, 03 Oct 2024 13:50:37 GMT

This invention is a highly stabilized trivalent cerium (Ce3+)-doped boron-aluminosilicate (BASL) glass created with the highest Ce3+ concentration among currently known glass materials. Analysis of Ce3+-doped BASL glass samples properties confirmed the absence of both strong concentration quenching and Ce3+ oxidation. This Ce3+-doped BASL glass has multiple special applications in advanced photonics manufacturing, laser applications, as well as high energy radiation and particle detection and visualization, medical imaging, radiation-resistant components and devices, neutrino and dark matter d...

Metrology System for Waveguide Display, Hologram and Grating Using Polarization Imaging

JianlingL@tla.arizona.edu — Thu, 03 Oct 2024 13:48:13 GMT

The invention is a method and design of a metrology system that is used to characterize polarization volume hologram (PVH), surface relief grating (SRG), and volume Bragg grating (VBG). Polarization of optical components such as the ones mentioned above can be used as waveguides, optical filters, lenses, reflectors, refractor, beam splitters, beam combiners, beam couplers, and compensators used in displays for augmented reality (AR), virtual reality (VR) and mixed reality (MR) systems. Background: The fabrication of and manufacturing of polarization components AR, VR, and MR systems are...

Dermoscopy Performance and Educational Phone Application

JianlingL@tla.arizona.edu — Wed, 02 Oct 2024 10:09:33 GMT

This invention is a dermoscopy phone app for dermatologists and clinicians that tracks diagnostic accuracy of skin biopsies obtained on dermoscope. The app will allow users to review their personal image library and utilize built-in app statistics to identify areas for improvement. Dermatopathologists reviewing the histology slides will have the opportunity to review the dermoscopy photos, which would provide valuable clinicopathologic correlation that could facilitate the interpretation of the pathology report. The app will have built-in statistics to identify core competencies for improvemen...

A Flavonoid Composition to Protect the Immune System of Pollinators Against Pesticides

JianlingL@tla.arizona.edu — Mon, 30 Sep 2024 11:47:34 GMT

Flavonoids are nutraceutical molecules used to improve health in humans and animals. This invention explores the use of flavonoid, rutin, to protect honey bees from the harmful effects of pesticides, specifically neonicotinoid imidacloprid. Pesticides can impair both the cognitive and immune functions of bees, making them more susceptible to diseases. This innovation demonstrated that rutin not only prevents the suppression of the immune system caused by imidacloprid but also enhances overall immune responses. This includes improving both cellular and humoral immune functions, such as th...

Space Traffic Management Architecture for Managing Space Stations and Spacecraft

JianlingL@tla.arizona.edu — Mon, 30 Sep 2024 11:46:32 GMT

The technology is a proposed space traffic management architecture to coordinate space stations and spacecrafts to facilitate clean-up of space debris. The architecture involves a space platform network that coordinates actions with rules in a common permanent orbit for management and space debris mitigation. Additionally, this network will work towards astronomical observation endeavors. Background: The use of small satellites has steadily increased over the years along with various forms of space travel, leading to more objects operating in crowded orbits. This can lead to scenarios l...

Modular Service Towers for Lunar and Mars Exploration

JianlingL@tla.arizona.edu — Mon, 30 Sep 2024 11:45:50 GMT

This technology involves the creation of modular service towers designed to support activities on the lunar and Martian surfaces. These towers are multi-functional, offering essential services such as lighting, power generation, and navigation. They also facilitate communication and computing for various lunar and Martian platforms, including robots, landers, and vehicles. Atop the towers are electronics modules containing computers, sensors, actuators, and communications equipment. The towers have environmental sensors that gather data on the surrounding environment, such as temperature, spac...

Method for Using Machine Learning to Identify High-Impact Donors

JianlingL@tla.arizona.edu — Mon, 30 Sep 2024 11:43:08 GMT

This innovation focuses on a novel approach to identifying high-impact donors to higher education using advanced machine-learning techniques. It was developed and tested as a proof-of-concept at the University of Arizona. By leveraging predictive algorithms, this method enables the university to pinpoint potential philanthropists who are most likely to contribute significant financial support. Unlike traditional donor prospect research methods, this method allows for faster and more accurate identification of high-value donors, optimizing fundraising efforts and improving fundraising results. ...

Closed Loop Control of Heliostat Motion

JianlingL@tla.arizona.edu — Fri, 27 Sep 2024 10:16:29 GMT

This invention is an apparatus and method for controlling the motion of heliostats, which are mirrors that reflect sunlight towards a common target. For heliostats to be maximally efficient, they must be able to shift in orientation precisely as the Sun’s relative position to the Earth changes. This technology utilizes a beamsplitter perpendicular to a heliostat reflector surface and to the incident and reflected rays of sunlight, as well as a camera that views both the sunlight transmitted through the beamsplitter and the sunlight reflected from the beamsplitter. By applying the law of ...

BASH-GN: A New Machine Learning–Derived Questionnaire for Screening Obstructive Sleep Apnea

JianlingL@tla.arizona.edu — Mon, 23 Sep 2024 09:18:02 GMT

BASH-GN is a machine learning-based questionnaire designed to classify the risk of obstructive sleep apnea (OSA) by considering various risk factor subtypes. Compared with other commonly used OSA screening tools, the BASH-GN questionnaire demonstrated superior performance, making it a more effective option for identifying at-risk individuals. This questionnaire makes the diagnostic process easier and helps healthcare providers take timely actions, improving patient outcomes and reducing the long-term health risks associated with untreated sleep apnea. Background: Sleep apnea is a severe...

Off-Label Use of an Anti-Hypertensive to Treat Epilepsy

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 15:52:03 GMT

University of Arizona researchers have found the angiotensin II receptor blocker, Candesartan, to effectively reduce epileptic activity. Background: As the most prevalent neurological disease, epilepsy is estimated to affect around 50 million people worldwide. In the United States, it is estimated that around 470,000 children and 3 million adults suffer from epilepsy. Anti-epileptic drugs can be expensive in both time and resources to research and develop; however, because Candesartan is already on the market to treat hypertension or heart failure, costly development could be avoided...

Photonic DNA Sequencing using Graphene Nanopores

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:26:41 GMT

This invention pertains to a novel method for DNA sequencing utilizing graphene nanopores and photonic detection to achieve high-resolution base detection. By combining graphene, which has exceptional electrical and mechanical properties that enable high-resolution base detection, with light-based detection that can use multiple wavelengths to simultaneously to detect different base pairs, this method achieves high-resolution, rapid, and accurate DNA sequencing. Background: DNA sequencing is important for understanding genetic information, identifying diseases, developing treatments, an...

Using Back-End-of-the-Line Wires in CMOS Process as Metal-Optic Antennas to Enhance Nonlinear Processes for Imaging Applications

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:24:11 GMT

This invention repurposes existing metallic wires in the complementary metal-oxide semiconductor (CMOS) process to function as metal-optic antennas to strengthen the specificity and efficiency of biological photodetection imaging systems, such as two-photon absorption detectors and upconversion imaging devices. This new method avoids the incompatibility of weak laser sources and increases the focus of light on the photodetector by increasing two-photon absorption. Background: Traditional photodetection imaging devices rely on various nonlinear processes and supplemental technologies, su...

Integrated Multi-Layer Lithography Method for Enhanced Resolution without Substrate Removal

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:23:54 GMT

This invention is a new lithographic technique for the enhancement of resolution using a multi-layer photoresist system. This new method avoids the need for substrate removal and allows for sequential patterning during multiple exposure processes. Without substrate removal, additional steps and realignment are unnecessary, thus expediting the process. Background: Traditional multi-step lithography processes to improve resolution often require multiple exposures with many intermediate development and realignment steps. These highly sensitive processes contribute to a lengthy and complica...

Conic Shield for Enhanced Radiative Cooling of Water Masses for Reduced Water Evaporation and Tackling Global Warming

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:22:30 GMT

This technology is a conic shield system to enhance radiative cooling and reduce evaporation in freshwater bodies such as reservoirs and lakes created by dams. Radiative cooling describes the passive cooling effect caused by emission of thermal radiation from an object. Water naturally experiences significant radiative cooling, but the cooling efficiency from bodies of water is often limited by their humid environments. This conic shield counteracts this problem via a mirror that directs infrared radiation away from the water while simultaneously reflecting it back into the atmosphere, using a...

Continuous Amplitude and Phase Modulation Using Rotary MEMS with Patterned Photonic Crystals and Metasurfaces

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:19:54 GMT

This technology uses photonic crystals on rotary microelectromechanical systems (MEMS) to achieve continuous amplitude and phase modulations in digital micromirror devices (DMDs) and other spatial light modulators (SLMs). By incorporating guided mode resonance (GMR) in photonic crystals and utilizing anisotropic and geometric phase metasurfaces, the invention achieves precise, continuous control over the amplitude and phase of reflected light. As the MEMS rotates, the polarization component of the incident light that excites the guided mode resonance (GMR) changes. This change in polarization ...

EUV-Compatible DMD Device Using Existing DMDs with Deposited EUV DBR Mirrors

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:18:52 GMT

This technology is a method of transforming standard digital micromirror devices (DMDs), which are compatible with visible and near-infrared light, into DMDs suitable for extreme ultraviolet (EUV) applications. This is done by depositing EUV-compatible mirrors onto each micromirror of a standard DMD. The resulting EUV-compatible DMD yields an efficient way to reflect EUV light and can be used in advanced EUV lithography systems to improve speed and resolution. This enables the use of the high-speed rotational capabilities of the micromirrors for rapid and accurate light modulation, which essen...

High-Speed Modulation Using Photonic Crystals on Digital Micromirror Devices (DMDs)

JianlingL@tla.arizona.edu — Mon, 16 Sep 2024 10:16:07 GMT

This technology integrates photonic crystals into digital micromirror devices (DMDs). The photonic crystals are incorporated on the surface of the DMD mirror in such a way as to achieve guided mode resonance, creating resonance features that are highly sensitive to changes in the angle of incidence. This increased sensitivity to angle changes minimizes the angular adjustments needed for a DMD to function, thereby reducing mirror travel distance and allowing for faster modulation while retaining precision. Background: Digital micromirror devices (DMDs) consist of many microscopic m...

Biomimetically Inspired Motor-less and Actuator-less Pump/Thruster

JianlingL@tla.arizona.edu — Fri, 13 Sep 2024 12:02:06 GMT

This technology is a motor-less, actuator-less, biomimetically inspired pump/thruster design that can operate in liquid environments within a wide range of environmental parameters, such as, but not limited to, high pressures, low temperatures, extreme pH values, and both polar (e.g., water) and non-polar (e.g., hydrocarbon) liquids. This makes it ideal for many uses, including biomedical applications. When used as a thruster, the technology can equip soft robotic agents with a motion similar to octopus or squid-like propulsion, using a peristaltic contraction. Such a soft robotic agent would ...

Utilization of Spirulina and Fish Oil or Algae Strains to Produce High Protein/Anti-Inflammatory Products

JianlingL@tla.arizona.edu — Thu, 05 Sep 2024 14:16:46 GMT

This invention combines cyanobacteria, specifically spirulina, known for its rich gamma-linolenic acid (GLA) content, with an optimal blend of fish oil or specific algae strains that are rich in eicosapentaenoic acid (EPA). The result is a product with a high protein content and unique ratios of GLA to EPA, offering a nutritional solution with potential anti-inflammatory benefits. This innovative formulation is designed not only to provide a high-protein dietary supplement but also to serve as a preventive measure against diseases and a support for overall health and well-being. The applicatio...

Modular Sea Vertical Farm (S-Vertical Farm) for Land Crops Cultivation and Modular Combined Above-Sea and Under-Sea Vertical Farm (AS/US-Vertical Farm) for Land Crops and Seaweeds Cultivation

JianlingL@tla.arizona.edu — Thu, 05 Sep 2024 14:10:49 GMT

Invention: University of Arizona researchers have developed a Modular Sea Vertical Farm (S-Vertical Farm) designed to decouple crop production from land use or land-use conversion to agriculture by using the sea surface as the area for vertical crop production. Background: The S-Vertical Farm module is designed with flexibility to have either a fully controlled (closed) or semi-controlled (semi-closed/open) environment. This novel method increases efficiency of the hydroponic crop growing system by employing a practical method of seawater evaporation and condensation to allow for ...

Modular Undersea Vertical-Hive Green Box (UV-Hive Green Box) for Seaweeds Cultivation

JianlingL@tla.arizona.edu — Thu, 05 Sep 2024 14:10:34 GMT

This invention provides a method of underwater vertical (U-Vertical) farming using vertically oriented grow boards for seaweed production, as well as other aquatic organisms such as scallops, mussels, oysters, clams, etc. Positioning and anchoring can be done through mechanical fixing, seabed anchors and floating buoys, with the ability to adjust via remote operation. This method allows for a zero-input agricultural approach as it doesn’t require any input, such as freshwater, fertilizer, feeds or need the constant manual labor typically required for farm maintenance and harvesting. Ba...

Protocol for Control-NOT and Control-PHASE gate between a Quantum Memory and Gottesman-Kitaev-Preskill Encoded Photonic Qubit

JianlingL@tla.arizona.edu — Thu, 05 Sep 2024 13:41:29 GMT

This innovation is a proposed interface between Gottesman-Kitaev-Preskill (GKP) qubit states (which are optimal for qubit transmission in quantum computing) and quantum memories (which can support long coherence and storage times) based on a cavity-mediated controlled displacement gate. The inventors prescribe optimal regimes of operation for high-quality quantum state transfer and extend this protocol to demonstrate the creation of GKP cluster states by avoiding the requirement of ancillary optical quadrature-squeezed light. This protocol enables many applications in hybrid quantum informatio...

Contactless Chronic Sensing of Epidermal Perspirants

JianlingL@tla.arizona.edu — Tue, 03 Sep 2024 16:19:32 GMT

This invention is a non-intrusive, highly accurate method to measure sweat rate without the need for direct skin contact. This approach uses 3D structured cavities with controlled diffusion dynamics to capture humidity resulting from sweat evaporation. The cavities consist of a staggered pillar structure seamlessly integrated into a well-established biosymbiotic wearable platform. Measurements are performed via commercial relative humidity sensors inside and outside the cavity, and robustness was demonstrated in a variety of experimental conditions with and without clothing. This contact-free ...

Apparatus and Method for High Solar Concentration using a Field of Twisting Heliostats

JianlingL@tla.arizona.edu — Tue, 03 Sep 2024 11:18:49 GMT

This technology is a twisting heliostat that automatically adjusts its reflector’s shape throughout the day to adapt to changes in the sun’s relative position to the heliostat field. It uses closed loop tracking to ensure that that light reflected from each twisted heliostat is centered on a target point. This design allows for higher concentration of solar energy with better efficiency than conventional heliostats with a fixed shape. Researchers developed and tested a prototype to validate the twisting heliostat design. Background: Heliostats are reflectors placed on rotati...

DNA as an Antimicrobial Agent for Preventing Neisseria Gonorrhoeae Infection

JianlingL@tla.arizona.edu — Tue, 03 Sep 2024 11:17:08 GMT

This invention encompasses a series of DNA-based antimicrobial compounds that prevent transmission of Neisseria gonorrhoeae (Ngo) during sexual intercourse and possibly treat an extant Ngo infection, alone or in combination with antibiotics, while leaving commensals unharmed. These DNA molecules are effective against low-passage antibiotic sensitive and resistant Ngo clinical isolates through a unique and experimentally proven mode of action. These “killer” DNA molecules have the following attributes: They have defined nucleotide sequences with homology to genes essential fo...

Digital Twin for Geomechanical Safety Monitoring

JianlingL@tla.arizona.edu — Tue, 03 Sep 2024 11:14:50 GMT

This technology is a 3D digital twin of rock mass used by mining experts and companies to monitor rock mass conditions to ultimately enhance mine safety. This comprehensive framework incorporates various geotechnical parameters, scanning technologies, and data acquisition systems to manage, analyze, and interpret the data to generate up-to-date 3D visualizations of rock mass. By wirelessly transferring data to a cloud-based server, the technology allows for near-real-time data visualization through heat maps, which help identify potential safety hazards. The system is interactive, allowing use...

Adaptive Wavefront Control System for Simulating Vision Correction

JianlingL@tla.arizona.edu — Tue, 03 Sep 2024 11:13:13 GMT

This device is an augmented/virtual reality system designed to assist patients suffering from visual impairments like cataracts and corneal scars. It has two modes: augmented reality (AR) mode in which it analyzes the scattering of light caused by a patient’s eye impairment and corrects for that scattering providing real-time vision corrects, and simulation mode, in which it assists in the selection of a treatment plan by simulating the vision of a patient after various potential surgical and non-surgical treatment options. The first functionality offers significant quality of life impr...

On-Chip Magnetometer

JianlingL@tla.arizona.edu — Wed, 28 Aug 2024 14:57:15 GMT

This innovation is a Photonic Integrated Circuit (PIC)-based magnetometer that can be used to measure nano- and sub-nano-tesla magnetic fields. High- sensitivity magneto optic nanocomposite materials are used as optical device cladding and/or device materials to register a shift in light polarization due to Faraday rotation. Devices based on evanescent field interaction may include ring/disc/ whispering-gallery resonators, on-chip adiabatic tapers or low-index contrast waveguide/clad configurations. Devices based on nanocomposite waveguides/devices may be fabricated directly from patterned nan...

Automatic Toilet Disinfectant Dispenser for Public Toilets

JianlingL@tla.arizona.edu — Mon, 26 Aug 2024 14:15:27 GMT

This invention is an innovative automatic disinfectant dispenser designed for use in public restrooms. This simple yet effective device aims to reduce the risk of disease transmission by ensuring consistent sanitation of toilet surfaces. The dispenser releases a controlled amount of disinfectant, such as sodium hypochlorite (bleach) tablets, which are known to be highly effective in sanitizing and disinfecting toilets after every flush. This device addresses the ongoing challenge of maintaining cleanliness in high-traffic public restrooms. The automatic nature of the invention ensures that eve...

Escape! A Multi-user Gaming App for Underground Mine Escape Training

JianlingL@tla.arizona.edu — Mon, 26 Aug 2024 14:13:11 GMT

Escape! is a multiplayer, turn-based strategy game for mobile devices designed to enhance emergency response and self-escape training for underground miners. Through engaging roleplaying scenarios that mimic real-life mine emergencies, the app helps miners improve decision-making and response times in high-stress situations. The app trains miners to locate and use resources efficiently, which can improve safety, reduce fatalities and injuries, and increase preparedness during underground emergencies. By placing miners in simulated high-stress situations that prompt crucial decision-making for ...

Advanced Occupational Knowledge-Based Authentication for Enhanced Digital Security

JianlingL@tla.arizona.edu — Tue, 20 Aug 2024 16:20:54 GMT

This technology is an advanced cybersecurity tool called Occupational Knowledge-Based Authentication (Occu-KBA). It enhances traditional identity verification methods by using occupation-specific questions. For instance, a doctor might be asked about medical terminology, while an accountant could face questions about financial regulations. By leveraging recent advancements in generative artificial intelligence (Gen-AI) and large language models like ChatGPT, it dynamically generates unique challenge questions tailored to the user's professional knowledge and experience, ensuring only those...

“Aquabot” - Marine Drones/Bots - Device, Method and System

JianlingL@tla.arizona.edu — Thu, 15 Aug 2024 08:14:24 GMT

This invention is a range of aquatic vessels designed as “drones” or “bots” capable of individual or collective action for water monitoring, collection of materials, or discharge of contents. As a system, these devices may be operated in an unmanned autonomous fashion or via remote control, or a hybrid of the two. Drones may function as a swarm or armada, for either “diagnostic” or “therapeutic” purposes. As diagnostic devices, they will have means of sensing, recording, and telemetered data which may be stored onboard or remotely, processed, and...

Myelin Breakdown Products as Plasma Biomarkers of Therapeutic Efficacy in the Acute Phase after Stroke

JianlingL@tla.arizona.edu — Mon, 12 Aug 2024 14:55:25 GMT

This invention pertains to the use of myelin breakdown products, such as lipids indicative of brain lipid catabolism, as plasma biomarkers for the diagnosis and prognosis of ischemic stroke (IS). Researchers discovered an acute signature of brain lipid catabolism in the plasma 24 hours after a stroke in mouse model research. Notably, a substantial proportion of these elevated lipids and metabolites were essential components of myelin. These experimental results offer insight into the metabolic alterations that occur in the plasma after a stroke and highlight the potential of myelin degradation...

Arachidonic Acid Derivatives as Plasma Biomarkers of Chronic Inflammation After Stroke

JianlingL@tla.arizona.edu — Mon, 12 Aug 2024 14:54:20 GMT

This invention pertains to the use of arachidonic acid derivatives as plasma indicators for the diagnosis and prognosis of inflammation, including chronic inflammation, following ischemic stroke (IS). Researchers have identified novel plasma biomarkers indicative of neurodegeneration and inflammation in a mouse model of stroke, with particular emphasis on one significantly altered within 24 hours during stroke recovery: 12-hydroxyeicosatetraenoic acid (12-HETE). Arachidonic acid, released from cellular membranes upon encountering inflammatory stimuli, serves as the precursor for 12-HETE synthe...

System and Methods for using Electrodermal Activity to Change Behavior vis Hunger

JianlingL@tla.arizona.edu — Mon, 12 Aug 2024 14:44:42 GMT

This invention uses a wearable smart ring sensor that can predict when people are about to eat via data collected through electrodermal activity. This invention uses that information to predict when people are about to eat, and engages a system that immediately alerts the user that they are about to reach for food. The app can offer mindfulness exercises to help users become more aware of their eating habits and make healthier choices. This technology can be especially beneficial for individuals trying to lose weight or those looking to gain control over their eating behaviors. By providing re...

Graphene Based Diode for Infrared Heating and Detection

JianlingL@tla.arizona.edu — Thu, 08 Aug 2024 09:14:32 GMT

This technology is an infrared light emitting diode (LED) designed for radiative heating applications. It utilizes a novel design based on nanostructured stacks of graphene sheets. Due to its flexible and lightweight design, it is suitable for a wide range of radiative heating applications including in fabrics and plastic sheets. The structure can also be used as an infrared light detector. Background: Infrared light emitting diodes (IR LEDs) are LEDs that emit wavelengths in the infrared spectrum. They have a wide range of applications in everything from motion sensors to safety monito...

Endoscopic Imaging Device with Wide Field and Confocal Imaging Capabilities

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 11:02:33 GMT

The TWICE (Transvaginal Widefield Imaging and Confocal Endoscope) invention is a low-cost, portable confocal endomicroscope for cervical malignancy diagnosis. The device combines the capabilities of widefield imaging (similar to mobile colposcopy) and confocal microscopy images, allowing users to obtain both macroscopic and high-resolution microscopic views of the cervix using a single device. This allows for a broader and more precise examination to ensure that no abnormalities are missed, as well as high sensitivity and specificity for malignancy detection, enabling accurate diagnoses. The e...

3D Printing Mirror (Radial Lithography Surface Figuring)

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 11:00:38 GMT

The technology enables less expensive fabrication of mirrors without compromising quality. This is done with a 3D printing technique that uses lasers and a rotating platform to craft the desired shape of the mirror. The new method can print mirrors that can be used in large-aperture telescope applications such as space telescopes. It can also fabricate mirrors with asymmetric surfaces. All 3D printing processes will be guided by ‘in-situ metrology’ that will provide optical quality guidance. Background: Additive manufacturing, also known as 3D printing, has shown potent...

Light Source with Tunable Spectrum and Polarization States

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 10:59:52 GMT

This technology is a light source that provides illumination with a tunable spectrum and polarization state using a single spatial light modulator. Compared to current tunable light sources, this system offers high power and a wide spectrum. Furthermore, the polarization state of each spectrum can be adjusted as needed without the requirement of an additional spatial light modulator. Background: Tunable light sources are an emerging technology that have gained importance in a range of industries, including biomedicine, materials science, and semiconductors, among others. The ability to ...

Apparatus and Method for Closed-Loop Heliostat Tracking

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 10:58:29 GMT

This technology is an apparatus and method to accurately orient a field of multiple heliostats to reflect sunlight to a single distant receiver. Higher accuracy tracking than previously realized is needed to fully exploit future heliostats that better concentrate sunlight on the receiver by forming a disc image of the Sun. This innovation overcomes limitations like inaccurate tracking of solar receivers and difficulty in receiving reliable operation data due to some tower images being much fainter and much more complex than the solar disc image. Background: Future heliostats that...

Polarization Application for Optical Sorting Machines

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 10:57:57 GMT

This software solution combines state-of-the-art polarization imaging with advanced post-processing and machine vision technology to improve optical sorting in recycling and waste management industries. By using polarized light and advanced algorithms, this innovative approach offers a faster, more accurate, and cost-effective alternative to conventional methods, optimizing recycling processes and ensuring consistently high-quality recycled materials. Background: In an increasingly eco-conscious world, efficient and accurate material sorting is essential for recycling and waste manageme...

Non-Scanning, Multi-Aperture Confocal Microscope

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 10:56:54 GMT

This invention relates to the design of a low cost, multi-aperture confocal microscope that can provide cellular images of human tissue in vivo. The main purpose is to use non-scanning all-passive confocal optics to conduct two-dimensional confocal imaging. The invention uses multiple apertures for each of the illumination and detection masks to increase the imaging speed and improve image resolution compared to a single aperture. This can be used for diagnosis of skin diseases, corneal diseases, and other human diseases, as well as industrial inspection applications, such as inspection of def...

University of Arizona’s Law Enforcement Training Library: Vol 1 Blue Envelope Program

JianlingL@tla.arizona.edu — Tue, 06 Aug 2024 09:35:31 GMT

This invention is for law enforcement training program designed to aid in communication between officers and individuals on the autism spectrum who are pulled over during a traffic stop. This new program utilizes blue envelopes to inform officers that an individual may have neurodivergences that could potentially negatively impact any interactions with law enforcement. The blue envelope serves as a nonverbal cue that can help inform the officer’s communication approach. Developed collaboratively between several University of Arizona units including the Department of Speech, Language, and...

Meta/Flat Optics Deflectometry

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:45:51 GMT

This technology is a unique solution for meta/flat optics metrology. It utilizes a direct matching interface between the flat/meta optics and the modulated pattern display. This allows for a much wider dynamic range than current technologies. This also enables higher measurement accuracy than current solutions like interferometry and traditional deflectometry at a lower price. By directly interfacing with the optics under test, this method ensures precise alignment and improved data quality, making it ideal for advanced optical engineering applications. Background: Meta-optics are devic...

Heliostat Deflectometry

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:44:58 GMT

This invention is a novel heliostat metrology method to analyze and assess heliostat quality. This method is designed for use with large format meter-scale heliostat mirrors. Through the use of a unique modulation-free pattern approach, this metrology method can be used in outdoor environments. In the context of heliostats, deflectometry is employed to ensure that the mirrors are accurately aligned and properly shaped to reflect sunlight onto a central receiver in concentrated solar power (CSP) systems. The novel deflectometry method provides a relatively inexpensive solution to solar energy a...

Cosmetic Hyaluronic Acid Binding Peptides

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:43:38 GMT

The invention focuses on developing a novel gel technology aimed at rejuvenating aging skin by targeting hyaluronic acid (HA) receptors. These receptors, crucial for skin hydration and elasticity, decline with age, contributing to skin aging. The gel incorporates peptides designed to mimic HA receptors, enhancing their binding to HA molecules and effectively restoring HA's function where it is most needed. By addressing the specific mechanisms of HA receptor decline the technology represents a promising advancement towards more effective anti-aging skincare solutions. Background:&nb...

A Novel Chemical Entity, Mary1, for the Treatment Mitochondrial Dysfunction, Vascular Injury, Kidney Diseases, and Organ Aging

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:41:28 GMT

This invention is a novel compound that can be used as a treatment for Acute Kidney Injury (AKI). This new method utilizes a small molecule agonist, capable of increasing mitochondrial biogenesis, which helps restore mitochondrial homeostasis and improves renal function and recovery. The compound showed beneficial effect in mouse model experiments. Background: Acute kidney injury (AKI) is a decline in kidney function, typically following intensive operations, resulting in increased morbidity rates. In 2022, prognosis after hospitalization for AKI was poor, particularly for those who had...

Radiative Cooling Devices and Air Conditioning Systems with Vertical Orientation

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:36:58 GMT

This invention is for radiative cooling devices and air conditioning (AC) systems for installation in vertical environments such as windows and walls. This new engineering features coatings with angular emissivity designed to optimize energy efficiency by targeting the zenith and avoiding thermal radiation output from nearby structures, while also shielding radiation from the Earth. Background: Radiative cooling systems typically have a horizontal orientation with unobstructed access to maximize exposure to the sky above. Contrarily, vertical systems struggle to achieve the same access ...

Augmented Reality System for Retinal Image Projection Using Photovoltaic Cells

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:36:24 GMT

This technology is a novel method of restoring vision loss associated with retinal disease using a wearable augmented reality (AR) headset alongside a retinal implant. The AR headset is used with a method to stimulate the optic nerve, which triggers natural processes to enhance the wearer's clarity and stability of vision. This technology incorporates an eye tracking system that aligns the image projection system with the wearer’s eye movements in real time, allowing the user comfortable, clear, and stable perceived images and making the system a viable option for everyday use. ...

Solar Control Surfaces with Angularly Selective Radiative Cooling

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:35:46 GMT

This technology is a solar control coating designed for passive radiative cooling applications. It’s designed with maximal ultraviolet (UV) reflectivity, visible spectrum transparency, minimal heat gain, selective handling of infrared (IR) wavelengths, and angular emissivity optimized for vertical applications. This design is ideal for usage on vertical surfaces like windows, and it optimizes daytime and nighttime radiative cooling efficiency while maintaining natural lighting. It can also overcome limitations of radiative cooling in humid environments. Background: Radiative cooli...

Plasmonic CMOS-Integrated Thermal Imaging Device

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:34:32 GMT

This technology is a thermal imaging device that uses plasmonic nanostructures integrated with a semiconductor device to enable infrared (IR) detection and imaging within a standard Complementary Metal-Oxide-Semiconductor (CMOS) framework. The device also has the ability to tune the resonance of the plasmonic nanostructures to specific infrared wavelengths, allowing for the detection of a variety of materials and substances based on their unique thermal signatures. By leveraging existing CMOS manufacturing processes, this technology can be produced at scale, reducing costs and making thermal i...

Ultrafast Nanoscale Stroboscopic Electron Microscopy System Using Temporal and Spectral Pulse Shaping

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:32:08 GMT

This technology is a method to enhance the temporal and energy resolution of electron pulses in ultrafast electron microscopy using pulse shaping techniques. A combination of optical components such as diffraction gratings and spatial light modulators allows for the temporal structuring of optical pulses which interact with and modulate an electron beam such that it produces multiple sub-pulses with distinct properties. This makes it possible to capture multiple temporal events in a single experimental setup and allows for imaging at resolutions in the femtosecond range. Furthermore, this tech...

Dense Optical Storage Media with Angular-Selective Thin Film Coatings

JianlingL@tla.arizona.edu — Mon, 05 Aug 2024 09:31:36 GMT

The invention is an improved optical storage media system designed to increase storage capacity on optical media, such as compact discs. This system encodes data by varying the width of pits on the disc, allowing each pit to represent multiple bits of information. By exploiting the diffraction properties of light, this technology employs angular-selective thin film coatings that filter diffracted light based on its angle. With the integration of a multiplex detector array, this approach allows for the encoding of multiple bits of information and enables precise determination of pit widths and ...

Designing Three-Dimensional (3-D) Printed Struvite and Calcium Oxalate Crystals for Microscopic Examination as a Teachable Clinical Skill in Healthcare Education Programs

JianlingL@tla.arizona.edu — Thu, 01 Aug 2024 13:59:22 GMT

This invention is the creation of micro-precision 3D printed models of simulated urine crystals for use as a urinalysis teaching tool in the field of veterinary medicine. These non-toxic models are meticulously designed and manufactured using high temperature laminating (HTL) resin, which ensures their durability and suitability for educational purposes over long periods of time. The ability to re-use these teaching tools lowers cost over time and is more reliable for testing students in objective structured clinical examinations (OSCES), as opposed to single-use tools that may deteriorate ove...

Polarized Light Detector and Emitter Based on Sub-Wavelength Wire and Wire Grid

JianlingL@tla.arizona.edu — Tue, 30 Jul 2024 08:58:19 GMT

This invention introduces a technology for detecting and generating polarized light. The polarization state of the light can be linear, circular, or elliptical. The polarized light detector enhances image clarity by revealing hidden signals and improving the quality of both color and monochromatic images, especially in environments with low contrast and a high level of unpolarized light. This technology is beneficial in various fields such as industrial metrology, surveillance, remote sensing, microscopy, and medical imaging. Additionally, the invention includes a method for generating polariz...

Aquaponics Media Cleaning System (AMCS)

JianlingL@tla.arizona.edu — Mon, 29 Jul 2024 08:46:52 GMT

The Aquaponics Media Cleaning System is designed to clean lightweight expanded clay aggregate (LECA) and other similar plant-supporting media between harvests. It utilizes an optimized, multi-stage process that streamlines the cleaning process, significantly reducing labor costs and water usage while enhancing operational efficiency. This process is driven by a microcontroller and is fully automated. Background: Aquaponics systems rely on efficient and effective growth media to achieve optimal plant growth, and lightweight expanded clay aggregate (LECA) has been found to be a high...

Geometric Phase Seismic Sensing using Green's Functions Obtained from Cross Correlation

JianlingL@tla.arizona.edu — Mon, 29 Jul 2024 08:45:03 GMT

This invention is a novel method of surface and subsurface detection in geological environments by using the geometric phase of seismic waves as a function of acoustic frequency. This method has application for accurate detection of oil and gas deposits, as well as enabling industrial application in sensing and discovery that are unavailable from current active source methods. Green's functions can be obtained from cross correlation techniques when either the location of an acoustic source is known or when it is unknown. The geometric phase as a function of frequency is a sensitive indicat...

In the Americas Season 10

JianlingL@tla.arizona.edu — Mon, 29 Jul 2024 08:41:00 GMT

In the Americas with David Yetman is an HDTV series that takes an in depth look at the heartland of Arizona, New Mexico, Sonora, and Chihuahua, and its peripheries and brings the region into the spotlight for the general audience. This show undertakes a new approach to travel and adventure with a focus on the western continents and islands. Season 10 covers the Four Corners, Colorado Plateau, northwest New Mexico, the Northern Jaguar Preserve on the US/Mexico border, San Ignacio Lagoon in Baja California, Lake Powell, and more. Background: The Southwest Center, an initiative of th...

Cholesterol-modified Sphingomyelin Lipid Bilayer for Drug and Gene Delivery

JianlingL@tla.arizona.edu — Wed, 24 Jul 2024 14:57:32 GMT

This invention is a new type of lipid vesicle or liposome that can be used to encapsulate drugs and genes for therapeutic applications. It improves upon existing liposome formulations in its increased stability, subsequent increased circulation time, and effectiveness as a nanocarrier. Background: For many years, therapeutic drugs were released in an uncontrolled and untargeted manner. This often resulted in drastic side effects, most dramatically exemplified by the side effects of chemotherapy treatment. Much research has been conducted to create more advanced systems for drug deli...

A Wearable Multi-Functional Ophthalmic Device for Monitoring Oculomotor Components

JianlingL@tla.arizona.edu — Mon, 22 Jul 2024 10:53:16 GMT

The invention is a wearable ophthalmic device designed to monitor various aspects of eye function crucial for clear vision. It combines several diagnostic capabilities into a single, user-friendly device. These capabilities include capturing detailed images of the retina (fundus), tracking eye movements accurately and measuring how well the eyes adjust focus (accommodation response). The device utilizes integrated light sources to illuminate the eye and display visual stimuli through a built-in screen. This setup enables comprehensive testing of oculomotor functions such as pupil size and the ...

EduVenture VR: A Virtual Reality Platform for Experiential Learning

JianlingL@tla.arizona.edu — Mon, 15 Jul 2024 09:02:49 GMT

Researchers from the University of Arizona have developed “EduVenture VR,” an innovative Virtual Reality (VR) platform designed to revolutionize workforce training for the modern industrial era, known as Industry 4.0. This platform addresses the urgent need to quickly reskill and upskill current workers while preparing new talent for roles in fields such as robotics, automation, and AI. EduVenture VR offers immersive, hands-on learning experiences that replicate real-world scenarios in a cost-effective, scalable manner, making it accessible to a large audience. EduVenture VR levera...

Pawlowski-Choi Imaging Spectrometer

JianlingL@tla.arizona.edu — Mon, 15 Jul 2024 08:56:54 GMT

This imaging spectrometer is a compact device designed to analyze light and determine its spectrum. While it is similar to the Czerny-Turner spectrometer design, it features notable differences that enhance its functionality. The spectrometer uses two spherical mirrors to direct and focus the light and incorporates a Littrow prism in a unique, non-traditional configuration. This innovative arrangement allows the prism to effectively fold and disperse the light beam, significantly improving its performance. The reflective face blocks most of the unfocused light from reaching the detector, which...

Measurement-Based Quantum Computing as a Tangram Puzzle

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 15:11:21 GMT

This invention is a game developed to teach Measurement-Based Quantum Computing (MBQC) to a wide audience ranging from high school students to quantum computing researchers via a Tangram puzzle with a modified set of rules played on an applet. The rules are stated in simple terms with no reference to quantum computing. Players must place polyominos on the playing board conforming to the rules. Any correct solution creates a valid realization of the quantum circuit in MBQC. A higher-scoring correct solution fills up less space on the board, creating a challenging and engaging research problem. ...

Virtual Ore Microscopy: An Interactive Cloud Application to Learn Optical Properties of Ore Minerals

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 15:10:56 GMT

This is a software application designed to provide an interactive virtual petrographic microscope that will allow users to study ore minerals and their microscopic features. This app digitizes polished thin sections of ore using both transmitted and reflected light allowing the user to explore alteration minerals associated with the ore. The app helps users understand the optical properties of various ore and alteration minerals formed in ore deposits without the need to have access to petrographic microscopes. The cloud-based database of ore samples also includes information about its geograp...

Core Administrative Program Suite

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 15:10:38 GMT

This technology comprises a comprehensive set of user-friendly business tools designed to enhance and streamline Core Facilities operations. It includes features like managing purchasing requests, reconciling procurement cards (p-cards), and controlling inventory. These tools are specifically tailored to meet the needs of Core Facilities, providing efficient solutions for smoother processes. Background: Currently, effective management of administrative and financial business tasks, such as purchase requests, p-card reconciliation, and inventory control can be cumbersome and prone ...

Advanced Fire Weather Analysis and Decision Making Dashboard

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 15:10:19 GMT

This technology is a dashboard that has the capability of gathering data from multiple independent forest service data sources to aid in the identification and prediction of potential fire weather, as well as the impact of weather on fire events. Moreover, the dashboard incorporates advanced machine learning algorithms for dynamic and predictive modeling, integrating streamlined data science methods, optimized aggregation, and visualization techniques, along with new fire weather forecast products. These features enable it to adapt to continually changing forest conditions and to provide proac...

Identity Verification using Answering Correctness and Behavior for Geo-Location Entities (Roads and Points of Interest) Relevant to a User's Primary Address

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 15:09:59 GMT

The Geographical Knowledge Based Verification (GeoKBA) System is an advanced multifactor verification service integrating a geographical component with digital behavioral biometrics to verify user identities in web-based interfaces. Conventional multifactor authentication (MFA) consists of “something you know” (e.g., a password) and “something you have” (e.g., a cell phone that receives a temporary code) to greatly enhance verification accuracy. GeoKBA extends this model, employing “something you know” and “something you do” by simultaneously tes...

Equanimity - Dynamic Physiology

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 15:09:28 GMT

This invention consists of a software package in combination with state-of-the-art hardware that is capable of continuously monitoring stress-related Heart Rate Variability (HRV). The software can recognize when HRV goes below a specified threshold and will prompt a yoga breathing exercise to increase HRV to healthier levels. The technology has the potential to provide a physiological marker and remedy for psychological stress for users. Background: Heart Rate Variability (HRV) is the measure of the variation in time between each heartbeat and is considered an index of vagal control of ...

Clinical Decision Support for HIT Diagnoses

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 14:58:45 GMT

This invention describes a method for ensuring the appropriate evaluation and diagnosis of heparin-induced thrombocytopenia (HIT). This method involves a novel scoring system for HIT based on drug administration and platelet counts over time, along with recommendations for proper treatment of HIT’s side effects. Background: Heparin-induced thrombocytopenia (HIT) occurs in 0.5% to 1% of patients exposed to unfractionated heparin for medical and surgical indications. Traditional methods of diagnosis and treatment include platelet count versus time graphs and 4Ts score calculat...

Quantum Natural Language Processing Based AI Model

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 14:57:38 GMT

This is a new model in artificial intelligence based on a very new technology called Quantum Natural Language Processing, which merges two major disciplines, AI/Computer Science and Physics. The AI model does natural language processing on quantum computers with weights initialized from the embeddings used in Large Language Models like GPT4, then adds up words using quantum entanglement. Background: While natural language processing has evolved significantly in the last several years, issues still remain in language differences, training data, complexities in language and semantic meani...

Artificially Intelligent Medical History Evaluation Instrument (AIMHEI)

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 14:57:17 GMT

The Artificially Intelligent Medical History Evaluation Instrument (AIMHEI) is an innovative system designed to enhance and optimize medical history interviews conducted by healthcare practitioners (HCPs). Utilizing advanced natural language processing, AIMHEI employs proprietary algorithmic modules and rubrics to meticulously analyze voice-to-text transcriptions of interactions between HCPs and patients. With over 36,000 operations for every 100 lines of text, AIMHEI evaluates interviews across sixteen major areas, including format, identification of details, and communication quality. The in...

Diagnostic Tool for Identifying Delirium using Electronic Medical Records

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 14:44:14 GMT

Neurologic, Orientation and Verbal Assessment of Delirium (NOVAD) is a smart-EMR screening tool designed to detect delirium in hospitalized adults. NOVAD leverages assessments that nurses are already familiar with to provide an early warning system for delirium detection, empowering healthcare professionals with actionable insights, leading to timely interventions and improved patient outcomes. With NOVAD, healthcare facilities can mitigate the risks associated with undetected delirium, such as increased morbidity and mortality rates, prolonged hospital stays, and higher healthcare costs. By s...

Identification, Creation and Facilitation of Lovebird Relationships

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 14:43:06 GMT

The "Lovebird Scale" is a tool designed to enhance the success of online dating by pinpointing couples who maintain long-lasting romantic connections. The scale is based on multiple studies by the inventors that revealed various loving behaviors, interactions, and cognitions that occur within exceptionally high-quality relationships, known as "Lovebird" couples, who have the potential to sustain deep love over time. Individuals are paired with compatible partners, aiming to recreate the enduring bond seen in Lovebird couples. Moreover, the scale serves as a valuable resourc...

Qordle: A Word Game to Introduce Quantum to Masses

JianlingL@tla.arizona.edu — Wed, 10 Jul 2024 14:42:03 GMT

This is a word game to teach people about quantum theory, similar to other word-based guessing games like Wordle and Wheel of Fortune. Based on recently found connections between Quantum Physics and Human Natural Language, this game uses Quantum Natural Language Processing (QNLP) to slowly introduce and teach quantum theory concepts to non-experts. Background: Quantum is colloquially recognized as a highly technical and complex field of study, yet is being used increasingly in computing, communications, security, and more. There is a great need to create a quantum-literate populat...

Development of Milk-Based Kefir using a Combination of Probiotic Lactobacilli Bacteria and the Dairy Yeast Kluyveromyces Marxianus var. Lactis (K. Lactis)

JianlingL@tla.arizona.edu — Tue, 09 Jul 2024 14:22:45 GMT

This innovation is a milk-based Kefir created from a popular commercial lactobacilli (LAB) culture mixed with the probiotic yeast K. lactis. Experimental formulations involved different amounts of K. lactis to find the optimal balance and various tests assessed the quality of the Kefir, such as measuring cell counts, pH levels, acidity, lactose content, and sensory analysis. The final Kefir prototypes matched the control product and also met the criteria for being considered probiotic, with higher viable cell counts and reduced lactose levels. These findings suggest that incorporating new prob...

Cow's Milk Yogurt made using Saccharomyces Cerevisiae var. Boulardii promotes Probiotic Levels and Extends GI Health Benefits

JianlingL@tla.arizona.edu — Tue, 09 Jul 2024 14:21:57 GMT

This innovation incorporates Saccharomyces boulardii, a probiotic yeast, into dairy products such as yogurt and kefir. With consumers seeking more options to increase their probiotic intake, the research aimed to investigate if S. boulardii could grow alongside traditional yogurt and kefir cultures to create products that meet both sensory standards and regulatory requirements. Through trials varying the levels of S. boulardii in combination with the traditional cultures, researchers successfully produced yogurt and kefir with acceptable characteristics in terms of taste, texture, and probioti...

Breast Density Bioelectrical Impedance Device Attachment

JianlingL@tla.arizona.edu — Tue, 09 Jul 2024 14:19:30 GMT

This technology is a device which applies bioelectrical impedance (BIA) principles to the breast for an estimate of breast density in order to provide a new screening tool for detection of breast cancer. BIA technology is applied to the limited area of breast as opposed to whole body measurements commonly used to assess adiposity. The goal of the breast BIA device is to reduce breast cancer health disparities by enabling a "pre-screening" of breast density (without radiation) that would indicate whether standard mammography screening should be undertaken. Populations particularly tar...

Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment

JianlingL@tla.arizona.edu — Mon, 08 Jul 2024 11:10:47 GMT

This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested. Background: It is estimated that in 2024, about 19,680 women will receive a new diagnosis of ovarian cancer and about 12,740 women will die from ovarian cancer. For those in remission, more than 80% of ovarian cancer patients experience recurrent disease, and more than...

Rigid Tube Stabilizer System (RTSS)

JianlingL@tla.arizona.edu — Tue, 02 Jul 2024 14:35:16 GMT

The invention is a rigid tube stabilizer system (RTSS) and three-ring release system to prevent entanglement with a drogue parachute during main canopy deployment. The RTSS unit is placed on the front of an individual who hand-deploys the system, activating a rigid tube that disallows entanglement with the system webbing, promoting free fall stability. Designed for skydivers, aviators and anyone who uses parachutes to deliver people or payloads, this technology will significantly improve parachute deployment safety. Background: When gear or skydivers are dropped from any altitude there ...

Method and Apparatus for Collaborative Error Correction using Quantum LDPC Codes and Message Exchange Among Iterative Decoders

JianlingL@tla.arizona.edu — Mon, 01 Jul 2024 09:56:10 GMT

Quantum low-density parity-check (QLDPC) codes are the leading candidate for performing error correction in scalable fault-tolerant quantum computing systems. This invention is a novel method and apparatus for collaborative decoders using QLDPC codes. These quantum decoders pass messages not only within the individual decoders that correct specific error types but also exchange information amongst each other to collaboratively correct multiple error types with excellent decoding performance and speed. Collaborative decoders using QLDPC codes will exchange information amongst each other in an i...

Radiative Cooling and Air Conditioning System with Enhanced Efficiency and Humidity Resilience

JianlingL@tla.arizona.edu — Mon, 01 Jul 2024 09:48:43 GMT

This technology is a radiative cooling and air conditioning (RC/AC) system that is highly efficient, performs under humid conditions, and is minimally impacted by parasitic heating (inherent loss of energy due to inefficiencies in an RC/AC system). These benefits are accomplished through the incorporation of three innovative components in the RC/AC system: a broadband solar reflector capable of reflecting the entire solar spectrum which makes daytime radiative cooling possible; the use of fluids and gasses with high thermal emissivity as the working fluid, making heat exchange between the syst...

Non-Invasive Biomedical Pressure Measurement Using Ultrasound-Induced Acousto-Optic Modulation

JianlingL@tla.arizona.edu — Mon, 01 Jul 2024 09:47:38 GMT

This invention is a novel method for measuring pressure inside the body without invasive procedures that combines ultrasound and laser technologies through the acousto-optic effect. By combining ultrasound and laser technologies, it offers a safe and accurate way to assess pressure levels in biological environments. An ultrasound wave is directed at the target area, such as the eye or brain tissue, which creates variable vibrations in the tissue depending on the internal pressure. At the same time, a laser beam is aimed at the vibrating tissue. When the ultrasound wave and laser light interact...

Efficient Colored Solar Panels and Cells with Integrated Coloration

JianlingL@tla.arizona.edu — Mon, 01 Jul 2024 09:36:33 GMT

This technology is a novel method of integrating vibrant colors into solar panels and cells without significantly compromising their performance. This is achieved through innovative optical coatings and structures that create narrowband resonances, allowing for selective color reflection or transmission while maintaining high levels of light absorption for energy conversion. Fano Resonant Optical Coatings (FROCs) provide coloration to amorphous solar cells and solar thermal panels, and guided mode resonances provide coloration to crystalline solar cells. This technology has diverse application...

Remote Phosphor Design for LED

JianlingL@tla.arizona.edu — Thu, 27 Jun 2024 14:42:49 GMT

This is a novel approach to LED device packaging by employing a reverse Cassegrain model within a micro-LED configuration. This design directs and mixes light efficiently, resulting in a high-performance LED package. The laser-driven white light source delivers high brightness, luminous flux, and high directionality for solid-state lighting applications. The technology is integrated into a standard Cassegrain optical model to develop a novel micro-LED device package that directs and mixes all lights of the system in order to optimize illumination and increase the output of the LED. The prototy...

Platform Development to Improve Bar Data Tracking, Analysis, and Reporting

JianlingL@tla.arizona.edu — Wed, 26 Jun 2024 09:26:33 GMT

This technology offers a modern solution for law schools to efficiently track and analyze bar exam performance data. This platform simplifies this process by enabling more sophisticated data management and analysis, allowing schools to identify key predictors of bar exam success and implement targeted study interventions. By leveraging this platform, law schools can generate comprehensive reports and gain deeper insights into student performance trends. This will help schools better support students in their exam preparations and enhance overall outcomes. The platform is designed to be a scala...

Novel, Humanized Transgenic Background Mouse Strain for Neurodegenerative Disease Research

JianlingL@tla.arizona.edu — Tue, 25 Jun 2024 09:33:37 GMT

This invention is a transgenic mouse model for the study of neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. This new model crosses a humanized APOE mouse model with a humanized APP gene, both common implicated genetic factors in Alzheimer’s Disease. The technology also developed a Parkinson’s Disease specific strain, where L444P and the GBA gene were crossed and developed for this novel mouse model. Background: In 2023, as many as 6.7 million Americans were living with Alzheimer’s Disease and 1 million people in the U.S. are living with...

Novel Mouse Strain for Inflammation and Neurodegeneration

JianlingL@tla.arizona.edu — Tue, 25 Jun 2024 09:32:10 GMT

This invention is a transgenic mouse model for the study of multiple sclerosis and rheumatoid arthritis. This new model crosses an HLA transgenic strain with a humanized apolipoprotein E (APOE) mouse model to create a useful tool for studying a wide array of neurodegenerative diseases, specifically the role of T-cell mediated inflammation. This new model enables the study of APOE genes, which are implicated in Alzheimer’s Disease, and antigenic T cell epitopes that are thought to contribute to T-cell inflammation in diseases like rheumatoid arthritis and multiple sclerosis (MS). As APOE ...

Tactile Feedback Sensor

JianlingL@tla.arizona.edu — Mon, 24 Jun 2024 10:25:28 GMT

This invention is a novel approach to tactile perception in robotic assisted minimally invasive surgery (RAMIS), focusing on deformation and texture detection. The invention consists of algorithms that aim to accurately classify objects with varying softness and roughness into corresponding deformation or texture labels. By designing and implementing a sensor-based system which comprises feature extraction and a recognition module, the surgeon can detect texture (the roughness of a biological organ on its surface) and deformation (tissue hardness / softness). It integrates two microelectromech...

Virtual Reality Simulation for Endonasal Surgery

JianlingL@tla.arizona.edu — Mon, 24 Jun 2024 10:22:42 GMT

Advancements in Virtual Reality (VR) technology have led to the development of a simulation software tailored for endonasal surgical training. This software utilizes VR to create immersive environments where trainees can practice various surgical procedures, particularly those involving intricate spatial anatomy like Functional Endoscopic Sinus Surgery (FESS). FESS presents challenges due to the tight operating space surrounded by delicate structures such as the brain and major blood vessels. The VR simulator addresses these challenges by allowing trainees to interact with realistic models of ...

Container Therapeutics at Point of Care

JianlingL@tla.arizona.edu — Mon, 24 Jun 2024 10:19:47 GMT

This technology is an innovative method and system for streamlining the production of therapeutic delivery systems. Central to this innovation is the integration of various stages of production, from raw material collection to final product delivery, within a mobile infrastructure. A key embodiment involves the utilization of a container-like structure equipped with advanced automation capabilities. This infrastructure enables seamless workflow management, encompassing vertical plant farming, vesicle isolation, purification, loading with therapeutic agents (both natural and synthetic), integra...

Making Quantum Computers Conscious Using QNLP

JianlingL@tla.arizona.edu — Mon, 24 Jun 2024 10:13:39 GMT

This is a proposed method to enable consciousness in quantum computers using theories from neurology, philosophy, physics and psychology. There is a correlation and correspondence between quantum computing and quantum consciousness. The relationship between the Orch-OR theory of consciousness and Quantum Natural Language Processing (QNLP) can be used in combination with quantum circuits mimicking microtubules to understand consciousness through human language acquisition. This is based upon a paper delivered at the Science of Consciousness conference and the technology is not reduced to practi...

Maximize Enhancement and Augmentation for Ultra-High Heat Flux Heat Exchange

JianlingL@tla.arizona.edu — Fri, 21 Jun 2024 14:53:33 GMT

This invention provides a series of special designs to apply multiple jets for impingement heat exchange to have dramatically enhanced heat transfer and augmented heat transfer surface. Both high heat transfer coefficient and large heat transfer surface contribute to high heat transfer rate. Particularly for concentrating solar thermal receivers that have a very high heat flux due to concentrated sunlight, this technology can greatly improve their performance and safety during operation. Background: Traditional high heat exchangers are less efficient regarding their heat transfer...

Amplified Entanglement Assisted Communication Outperforming Classical Laser Communication in Strong Atmospheric Turbulence Regime

JianlingL@tla.arizona.edu — Thu, 20 Jun 2024 11:40:52 GMT

Contrary to the common belief that quantum entanglement is destroyed by amplification, in entanglement-assisted communication systems dominated by attenuation effects rather than noise, the signal photons can be amplified by the erbium-doped fiber amplifier (EDFA) without destroying the entanglement. The inventors developed a terrestrial free-space optical (FSO) testbed at the University Arizona campus by establishing 1.5 km long FSO link. They demonstrated that an amplified entanglement assisted communication system at 10 Gb/s operated in strong turbulence regime significantly outperforms amp...

Entanglement Based CV-QKD with Information Reconciliation over Entanglement Assisted Link

JianlingL@tla.arizona.edu — Thu, 20 Jun 2024 11:39:54 GMT

This invention is an entanglement-based continuous variable-quantum key distribution (CV-QKD) scheme that performs information reconciliation over the entanglement assisted communication link. The same entanglement generation source is used in both raw key transmission and information reconciliation. Experimental demonstrations over the free‐space optical testbed established at the University of Arizona campus indicate that the proposed CV‐QKD scheme with information reconciliation over the entanglement assisted link significantly outperforms corresponding CV-QKD scheme with information reconc...

Optimized Receiver Design for Entanglement-Assisted Communication using BPSK

JianlingL@tla.arizona.edu — Thu, 20 Jun 2024 11:39:33 GMT

This technology proposes a new receiver design employing 2x2 optical hybrid receiver to optimize entanglement-assisted communication specifically using Binary Phase-Shift Keying (BPSK). This new method leverages prior work that discovered that pre-shared entanglement allowed for higher communications rates and optimizing the receiver now allows for significantly higher communication rates compared to conventionally (Holevo and Homodyne) capacities. This technology increases the security in free-space optical transmission and reduces the probability of interception of the technology. This tech...

Optimized Regular and Irregular SD-LDPC Codes for 50G-PON and Beyond

JianlingL@tla.arizona.edu — Thu, 20 Jun 2024 11:38:39 GMT

This technology is a low-density parity-check (LDPC) code optimization for optical transmission (fiber) taking into consideration known burst mode errors. By using parity-check matrix rearrangement and different intra-codeword interleaving, the inventors demonstrated that both regular and irregular LDPC codes' performance can be improved under burst mode errors by using the proper optimization. Background: Low-density parity-check (LDPC) codes are widely used as a forward error correction solution (FEC) in optical transmission systems to provide the error correction performance clos...

Two-Pumps-Based Entanglement Generation Source Enabling Entanglement-Assisted Communication over Turbulent Free-Space Optical (FSO) Channels

JianlingL@tla.arizona.edu — Thu, 20 Jun 2024 11:37:50 GMT

This technology improves Quantum Entangled Free Space Optical Communication by employing two laser pumps and modulating on the signal photons, while employing the idler photons as the reference signal. The use of two pumps gives the flexibility of generating the signal photons at arbitrary wavelength in C- and L-bands, which is not possible with the single pump configuration. This configuration allows for highspeed communication over longer distances than previous versions of the technology. The proposed entanglement-assisted communication system at 1 Gb/s and beyond, employing the entan...

Enhanced Photocatalytic Water Purification System Using Ultrathin Metal-Oxide Films on Reflective Substrates

JianlingL@tla.arizona.edu — Mon, 17 Jun 2024 11:41:01 GMT

This invention is a photocatalytic water purification system that utilizes ultrathin metal oxide film deposited on reflective substrates to enhance light absorption and increase overall efficiency of water purification in a variety of small- and large-scale applications. The metal oxide film is engineered to absorb light optimally at the interface between the film and the substrate, creating conditions that increase the generation of reactive oxygen species for enhanced photocatalytic reactions, which are crucial for the breakdown of contaminants. This design allows for efficient degrada...

Polarization Imaging Device Using Modified CMOS Back-End Metallic Wires

JianlingL@tla.arizona.edu — Mon, 17 Jun 2024 11:37:54 GMT

This invention is a novel method of modifying complementary metal-oxide semiconductor (CMOS) chips to detect polarization data. This technology aims to revolutionize polarization imaging by leveraging the existing infrastructure of CMOS technology through converting metallic wires in the back end of the line of a CMOS chip into linear polarizers (wire grid polarizers) or chiral metamaterials for circular polarizers. In doing so, the device can fully describe the polarization state of light. This is achieved by integrating polarizing components directly into the sensor array, allowing for compa...

Apparatus and Method for Direct Air Capture of CO2 Using Focused Solar Energy

JianlingL@tla.arizona.edu — Tue, 11 Jun 2024 10:39:21 GMT

This invention is a method of direct air capture (DAC) focusing on the capture of carbon emissions purely from sunlight alone. A modular, self-contained apparatus is used to capture dilute carbon dioxide (CO2) from a heat-based chemical reaction, then the energy is used to release the CO2 in concentrated form, for sequestration in the ground. The process can be repeated constantly while enabling a low-cost, more efficient method to generate the energy required for DAC of CO2. This cost-effective method offers a new approach to solving climate change problems. Background: With many direc...

Advanced Condensation Nuclei (CN) Counter

JianlingL@tla.arizona.edu — Tue, 11 Jun 2024 10:38:21 GMT

This technology is an apparatus and method for detecting, counting, and recording properties of ultrafine particles (<0.1 microns) compactly and inexpensively for more detailed, accurate analyses of particle numbers and particle size distributions in a variety of markets, such as for air quality, home health, and clean room control. Background: CN counters are widely available, but counters that can detect particles at ultrafine particle sizes (<0.1 microns) are very expensive (tens of thousands of dollars). This invention could make the detection of these very small particles ach...

AI Medical Scenario Template

JianlingL@tla.arizona.edu — Fri, 07 Jun 2024 15:23:07 GMT

The Artificially Intelligent Medical Scenario Creator, or AIMSC, is a tool designed to help educators build customized virtual patients (VPs) for medical training. These VPs are like interactive avatars that simulate real-life patient encounters. With AIMSC, educators can create scenarios tailored to specific learning objectives, allowing healthcare practitioners (HCPs) to practice medical history interviews and physical examinations in a realistic virtual environment. This tool acts as a foundation for a larger system called Artificially Intelligent Medical Mentoring System (AIMMS), which aim...

Applications of Deuterated Aldehydes and Isonitriles

JianlingL@tla.arizona.edu — Fri, 07 Jun 2024 14:43:25 GMT

This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can increase the duration of protection provided to the arteries and prevent calcium from damaging them. Background: There has been a growing need for deuterated molecules, as they have begun playing an increased role in inhibiting certai...

Fall Prediction Monitor and Risk Assessment

JianlingL@tla.arizona.edu — Thu, 06 Jun 2024 13:15:57 GMT

By harnessing the power of radio frequency imaging and video cameras, this system captures and analyzes individuals' movements within a room to significantly reduce the risk of fall accidents. Through sophisticated AI processing, it then generates a comprehensive risk assessment profile, enabling the prediction, prevention, and identification of potential falls. By providing real-time insights and actionable data, healthcare professionals can feel empowered to deliver even higher standards of care while enhancing the overall safety and well-being of those under their care. Backgroun...

Small Molecule Therapeutics for SARS and MERS

JianlingL@tla.arizona.edu — Wed, 05 Jun 2024 10:08:32 GMT

This technology introduces a potent covalent enzyme inhibitor designed specifically for targeting the cysteine protease, PLpro, a key player in the replication process of SARS coronaviruses like SARS-CoV-2 and MERS. Unlike traditional small molecule inhibitors, this inhibitor offers unparalleled efficacy and specificity, making it a promising candidate for combating viral infections. By precisely targeting PLpro, the virus's ability to replicate and evade the host immune system is disrupted, ultimately inhibiting its spread within the body. With the global need for effective solutions agai...

Fecal Containment Obstetric Drape

JianlingL@tla.arizona.edu — Wed, 05 Jun 2024 10:05:57 GMT

This technology is an obstetric under-buttocks drape that has an additional flap located above the fluid collection portion for use during labor and delivery in childbirth. This is a one-size-fits-all flap that has an adhesive lining at the top, allowing for adhesion to the patient’s perineum and across the patient’s back thighs. The flap will not interfere with the delivery of the infant as it is located inferior to the vaginal introitus. This will create a sealed barrier between the sterile field and any defecation so that the infant will not encounter fecal matter. Providers can...

Data Acquisition and Measurement of Characteristic Functionals in Biology and Medicine

JianlingL@tla.arizona.edu — Mon, 03 Jun 2024 16:46:33 GMT

This invention provides methods for determining and estimating joint characteristic functionals of biological and physiological processes using tomographic imaging. By modeling these mechanisms and interactions as biologically accurate yet mathematically tractable models, the statistics of which are fully described by joint characteristic functionals, this method enables the study of complex diseases, such as tumors and viral infections, and the biological processes involved with disease progression and response to treatment. Background: All disease processes are enormously compli...

Clinical Decision Support for HIT

JianlingL@tla.arizona.edu — Mon, 20 May 2024 11:42:23 GMT

This invention is clinical decision support (CDS) for the evaluation and diagnosis of heparin-induced thrombocytopenia (HIT). It involves the use of a HIT computerized-risk (HIT-CR) score to guide diagnostic support decisions to ultimately reduce unnecessary testing and misdiagnosis. Background: Heparin-induced thrombocytopenia (HIT) occurs in 0.5% to 1% of patients exposed to unfractionated heparin for medical and surgical indications. Appropriate evaluation of HIT is imperative because of potentially life-threatening complications; however, over-testing and overdiagnosis of HIT ...

Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI

JianlingL@tla.arizona.edu — Mon, 13 May 2024 14:32:59 GMT

This innovation is the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change in cTnT, it alters the environment around cTnI, which the probe detects by changes in fluorescence. Essentially, the probe acts like a sensor that fluoresces when it detects certain changes in the heart muscle. The purpose of this innovation is to aid ...

SubsetTools

JianlingL@tla.arizona.edu — Fri, 10 May 2024 09:07:05 GMT

This software package is designed to allow users to take advantage of the HydroGEN national hydrologic modeling platform to generate their own watershed model. Subset tools can easily provide a working model for any watershed in the United States that the user can then take to generate any simulations they would like. A python package that allows users to interact with large hydrologic modeling datasets to build their own watershed model. Learn more about this package at hydroframe.org/subsettools. Background: Water is the driving force behind extreme weather events, damaging the ...

National Hydrologic Simulation Database

JianlingL@tla.arizona.edu — Fri, 10 May 2024 09:06:47 GMT

This database includes simulation input and outputs from the ParFlow CONUS 1 and 2 models for use in connection with the HydroGEN system for hydrological modeling. More information on these models can be found at https://hydroframe.org/parflow-conus1 and https://hydroframe.org/parflow-conus2. ParFlow is one of the most physically rigorous hydrologic models available and is unique because it simulates both the subsurface and the land surface at the same time. The HydroGen National Hydrologic Simulation Database is the only ParFlow model of the entire US and was used in multiple scientific ...

HydroData Toolkit

JianlingL@tla.arizona.edu — Fri, 10 May 2024 09:06:16 GMT

HydroData is a python package and toolkit for working with point observations and gridded model datasets of hydrologic systems in the United States for use in connection with the HydroGEN system for hydrological modeling. HydroData is available at https://hydroframe.org/hydrodata. The goal in developing the HydroData toolkit was to evaluate watershed conditions across many variables at once all with one interface. Background: Water is the driving force behind extreme weather events, damaging the nation’s people and economically straining the US. Hydrological research, analys...

HydroGEN Forecast Generator

JianlingL@tla.arizona.edu — Fri, 10 May 2024 09:05:45 GMT

HydroGEN is a web-based platform for hydrologic simulation utilizing advanced machine learning algorithms and current data to provide accurate forecasts to water managers and other decision makers. The HydroGEN Forecast Generator is a workflow that builds a hydrologic model for any watershed in the United States and seasonal runs forecasts using a machine learning emulator. This workflow makes it possible to generate a seasonal forecast for any watershed in the US on demand. The hydrological simulated models go beyond streamflow scenarios and are designed to provide complete watershed systems ...

Text Data Describing Examples of Characteristics of Autism Spectrum Disorders (ASD)

JianlingL@tla.arizona.edu — Thu, 09 May 2024 15:54:22 GMT

This technology is a text data set of characteristics of Autism Spectrum Disorder (ASD), consisting of “human-labeled” and “machine-labeled” data. The dataset consists of fragments of clinical text describing ASD typical behaviors in children. This data set will be used by algorithms for a number of applications. One application would be to serve as a training system for clinicians to better diagnose and recognize ASD in young children. Another application, for a more commercial audience, would be to use this algorithm in Alexa-like devices to allow parents to match beh...

Online Interface to Process Text and Identify Characteristics of Autism Spectrum Disorders (ASD) in the Text

JianlingL@tla.arizona.edu — Thu, 09 May 2024 15:53:26 GMT

This software allows individuals to submit text and have segments of that text be highlighted and grouped based on if they are diagnostic criteria when testing for autism spectrum disorder (ASD). Highlighting is performed based off different criterion and displayed in different colors. There is also a summary count of all criteria found and their frequencies provided via this software. Background: The diagnosing process for autism is difficult since there is no medical test that pinpoints the disorder. In order to diagnose ASD doctors, clinicians need to look at a variety of chara...

Algorithm to Process Text and Identify Characteristics of Autism Spectrum Disorders (ASD) in the Text

JianlingL@tla.arizona.edu — Thu, 09 May 2024 15:52:58 GMT

This technology is an algorithm that takes natural language text as an input, and uses rule-based and machine learning techniques to identify behaviors that are consistent with the diagnostic criteria for autism spectrum disorders (ASD). It suggests a diagnosis and highlights and summarizes the relevant information to aid a clinician’s decision making process. Background: The prevalence of ASD is on the rise. A 2018 study by the CDC estimated that about 1 in 44 children in the US have ASD. Early detection is the best way to minimize developmental challenges among children with ASD...

Rodent/Small Mammal Animal-Free Surgical Training System and Components

JianlingL@tla.arizona.edu — Tue, 07 May 2024 15:41:45 GMT

This innovation is an animal-free surgical training simulator for use in biomedical research. The system comprises anatomically accurate simulators and step-by-step protocols for training in surgical techniques. The component parts of the simulators can be produced through cost-effective 3D printing, making the system affordable and customizable. These simulators aim to replace live animal use in training and reduce the number of animals involved in research, aligning with the principles of the 3R philosophy. Researchers can practice surgical skills and techniques on these simulators, resultin...

A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells

JianlingL@tla.arizona.edu — Tue, 07 May 2024 14:10:24 GMT

MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target gene relationships in insect cell lines. The promoters for the target luciferase in insect cells are too weak to drive sufficient expression of the target luciferase in insect cells. This technology replaces the promoter used for the mamma...

Fabrication of Metasurfaces in Standard CMOS Foundry Processes

JianlingL@tla.arizona.edu — Tue, 07 May 2024 11:41:57 GMT

This invention discloses a novel approach to integrating metasurfaces with standard Complementary Metal-Oxide-Semiconductor (CMOS) processes, a significant advancement in the field of photonics and nanofabrication. This approach leverages a bulk CMOS foundry process for the fabrication of metasurfaces and experimental results show that three primary ones: Geometric Phase, Resonant, and Huygens Metasurfaces, can be fabricated, as well as dielectric metasurfaces. Background: Metasurfaces, defined as two-dimensional arrays of nanostructures, enable precise manipulation of light at su...

Suspended Nanomembrane-Based EUV Lithography System with Diffractive Optical Elements and Transmission Masks

JianlingL@tla.arizona.edu — Tue, 07 May 2024 11:38:38 GMT

This technology is a novel approach to extreme ultraviolet (EUV) lithography by creating a transmission-mode EUV lithography system using suspended nanomembranes. The core idea is to utilize nanomembranes which are ~50-100 nm thick suspensions on the order of a few mm squared. The membranes can be made of silicon or its derivatives. Moreover, they are produced on a wafer scale. The fact that they are thin allows them to be patterned with ebeam lithography or focused ion beam milling where etched portions are holes which allow the transmission of EUV wavelengths. This invention addresses a crit...

Methods and Apparatus for Microscope for Imaging Eyes

JianlingL@tla.arizona.edu — Tue, 07 May 2024 11:33:35 GMT

The Portable In-Vivo Confocal Ophthalmoscope (PICO) addresses the need for a cost-effective and portable ophthalmic imaging solution for obtaining microscopic images of the anterior segment of the eye and external eye structures. The unique combination of optics and confocal microscopy enhances the imaging quality during a non-invasive and comfortable examination of the eye. A distinguishing feature of the PICO is its capability to capture en face images of the entire external eye and anterior segment, providing a comprehensive view of ocular structures. The integration of this technology into...

A Polarized Light Source for the Thermal InfraRed using COTS Wire-Grid Polarizers

JianlingL@tla.arizona.edu — Tue, 07 May 2024 11:28:23 GMT

This invention is a thin wire filament that can produce polarized thermal emission when heated. Using commercial off the shelf wire-grid elements, a polarized thermal source with an extended spatial profile can be fabricated. Such a well-characterized polarized source in the thermal infrared can be used for the verification, validation, and in-flight calibration of airborne and space-based thermal polarimeters. Background: Traditional calibration technologies for polarimeters use either a Sodium light source or a standard quartz crystal designed for the specific application. Appl...

Heat Smart AI: An Unparalleled Platform for Enhancing Urban Heat Resilience

JianlingL@tla.arizona.edu — Fri, 03 May 2024 16:27:21 GMT

HeatSmart AI leverages artificial intelligence and machine learning to predict extreme heat risks in urban environments. In times of extreme heat, people living in cities are the most heavily impacted, as urban areas tend to be hotter than surrounding non-urban areas. These impacts can be incredibly dangerous, as heat is the number one weather-related killer in the United States. HeatSmart uses advanced predictive analytics on diverse datasets to analyze and predict urban heat risks, which can allow for advanced warning and time to implement cooling measures to protect city residents and enhan...

Eco-Chain Bonds: Revolutionizing Green Bond Investments with AI and Blockchain

JianlingL@tla.arizona.edu — Fri, 03 May 2024 16:26:58 GMT

EcoChain Bonds is a green bond solution that harnesses the power of blockchain and artificial intelligence. The use of blockchain helps to build trust among stakeholders by providing transparency in a clear and secure record of financial activities. Moreover, the integration of AI algorithms can analyze vast amounts of data with unprecedented speed and accuracy, offering valuable insights into investment opportunities and risks associated with renewable energy projects. By leveraging AI-driven analytics, EcoChain Bonds not only simplifies the investment process but also enhances decision-makin...

Heat Hero Academy

JianlingL@tla.arizona.edu — Fri, 03 May 2024 16:25:28 GMT

HeatHero Academy is an educational program aimed at youth with the goal of raising awareness and empowering students and their communities to combat urban heat. This program aims to foster climate resilience and inspire students to engage in environmental issues. It combines immersive augmented reality technology with hands-on citizen science projects, in which students can actively engage with and solve real-world urban heat problems. Background: Cities tend to be warmer than their surrounding suburban and rural areas, leaving their communities more at risk during heat waves. The...

Modeling and Control of a New Deformable Copter-Powered Unmanned Aerial Vehicle (UAV)

JianlingL@tla.arizona.edu — Thu, 02 May 2024 12:03:25 GMT

This invention contains motion and control models for a deformable copter-powered unmanned aerial vehicle (DCU). These models expand a drone’s capabilities of safe and aggressive deformation in constrained environments and enable tracking control that is decomposed into force and altitude controls and presented as quadratic programming problems. The UAV can generate distributed control force and moment vectors in any direction in 3D, thus it has better stability and tracking performance, can resiliently operate under partial failures, and has better robustness against external disturbanc...

A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting

JianlingL@tla.arizona.edu — Thu, 02 May 2024 11:44:26 GMT

The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer and diffusion models to forecast vital signs. The TDSTF model showed state-of-the-art performance in predicting vital signs in the intensive care unit, outperforming other models’ ability to predict distributions of vital signs and being mor...

MTS-LOF: Medical Time-Series Representation Learning via Occlusion-Invariant Features

JianlingL@tla.arizona.edu — Thu, 02 May 2024 11:44:07 GMT

Medical Time Series Representation Learning, known as MTS-LOF, uses the strengths of contrastive learning and Masked Autoencoder (MAE) methods, providing more sophisticated, context-rich representations, while also clarifying the interplay between temporal and structural dependencies in healthcare data. MTS-LOF is ideal for integration into numerous healthcare applications, ranging from sleep quality analysis and fall detection to seizure prediction. Furthermore, there is potential to refine MTS-LOF for deployment on smartphones integrated with wearable sensors, such as smartwatches and EEG he...

Neurodiverse Learners Endorsement & Training Program

JianlingL@tla.arizona.edu — Thu, 02 May 2024 11:43:07 GMT

The Strategic Alternative Learning Techniques (SALT) Center is an international leader in developing and providing personal, educational, and mental health/wellness services to support higher education students who learn differently. The SALT Center’s Neurodiversity Endorsement & Training Program helps university leaders, faculty, staff and administrators learn how to effectively engage students who are neurodiverse and their families. The training is completed in a series of online modules and endorsement is granted upon demonstration of knowledge and skills gained. Background:&nbs...

University of Arizona Strategic Alternative Learning Techniques (SALT) Center

JianlingL@tla.arizona.edu — Thu, 02 May 2024 11:28:06 GMT

The Strategic Alternative Learning Techniques (SALT) Center is an international leader in developing and providing personal, educational, and mental health/wellness services to support higher education students who learn differently. Through direct service, research, and thought leadership the SALT Center provides a replicable model through which to support the success, retention and graduation of neurodiverse individuals with mild to moderate impairments in higher education. The SALT Center has the opportunity to serve a diverse range of students, working to alleviate educational disparities ...

Method and Apparatus for Full Spectrum Polarization Imaging

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 14:08:27 GMT

This technology is a novel imaging method and apparatus combining full-spectrum and polarization imaging techniques. While full spectrum imaging captures the entire spectrum of light, polarization imaging measures the polarization state of light, providing valuable information about the surfaces and materials it interacts with. By this method, polarization information can be gathered across a full spectral range. This imaging method can detect information invisible to human eyes and has a high signal-to-noise ratio making it an effective choice for dark environments and night-time usage. Chrom...

Solvent-Free Silsesquioxane for 3D Printing Glass Optics

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 14:05:38 GMT

3D printing of glass has demonstrated potential in diverse fields, such as photonics, imaging, and microfluidics. Researchers at the University of Arizona have developed a solvent-free polymeric silsesquioxane (PSQ) resin for 3D printing glass objects with high precision through a two-photon polymerization (TPP) method. The PSQ resin exhibits reduced shrinkage and enhanced moisture stability while retaining sinterless characteristics for high-resolution 3D printing of glass objects. Experimental results yielded nanostructures with feature sizes below 80 nm. Incorporation of zirconium moieties...

Compact Image-Guided Surgical System

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 14:05:22 GMT

This invention is a compact intraoperative imaging device utilizing fluorescent near-infrared (NIR) imaging and projection during surgery to project light onto biological tissue. The device can operate as a handheld or head mounted device, allowing for hands-free imaging with increased brightness and view of the object. Light shaping and patterning directly at the source for targeted energy delivery is a benefit to this type of biomedical imaging. Background: Common surgical imaging techniques require surgeons to sacrifice focus and free hands during surgery to retrieve and operat...

Method and System for 3D Imaging using Deflectometric Information and Polarization

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 14:03:00 GMT

This invention describes a novel method of 3D reconstruction imaging, utilizing a blend of deflectometry and shape from polarization (SfP). In order to overcome the limitations of current methods of 3D imaging, the technology will pursue exploitation of deflectometric and SfP information to achieve an overall faster 3D reconstruction with polarization camera and single shot deflectometry pattern. Background: Classical deflectometry and shape from polarization limitations include two main issues: shape from polarization (SfP) normal ambiguity problem and assumption of orthographic projec...

Method and System for Eye Tracking using Structured Light

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 14:02:43 GMT

This invention represents a significant advancement in the field of eye tracking technology by introducing a novel deflectometry approach to enhance accuracy that relies on leveraging dense 3D information obtained from the eye surface to estimate gaze direction. The key objective is to substantially decrease gaze estimation errors, aiming to improve from the current range of below 0.25° to 0.45°, down to an impressive level below 0.1°. This substantial reduction in errors holds the promise of pushing the boundaries of eye tracking precision and opens up new possibilities for applic...

Advanced Radiative Cooling System for CMOS Chips Using Integrated Metal-Optic Layers

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 14:02:08 GMT

This invention leverages recent advancements in nanophotonics and electronics to develop an advanced radiative cooling system for Complementary Metal-Oxide-Semiconductor (CMOS) chips with minimal change to the CMOS chip design. This cooling system incorporates metal-optic layers directly into the chip’s architecture within bulk CMOS foundry processes, demonstrating that the back-end-of-the-line (BEOL) can serve as effective metal-optic devices. The process enhances cooling efficiency while maintaining the chip’s structural integrity and performance. Additionally, it enables creatin...

A Method for Label-Free, Non-Invasive Acquisition and Mapping of -Omics Data

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 13:56:48 GMT

This technology describes a novel process to generate -omics data, such as genomics, proteomics, and more, through optical imaging. The invention is intended to implement spatial imaging techniques to identify optical imaging markers that can be predictors of -omics. This technology has potential for usage in a variety of fields including in vivo or ex vivo diagnostics, subtyping, phenotyping, or pathology understanding. Background: This technology could have a groundbreaking impact on medical techniques and technologies by enabling a rapid, non-invasive, and non-destructive techn...

Photocurrent Bias for Event-Based Sensor (EBS)

JianlingL@tla.arizona.edu — Wed, 24 Apr 2024 09:08:03 GMT

The Photocurrent Bias for Event-Based Sensor (EBS) is a method designed to enhance the performance and effectiveness of event-based sensors, particularly in challenging environments. This innovative technology leverages the application of a spatially homogeneous light field onto the sensor's imaging path to significantly reduce low-level illumination noise. This approach ensures higher precision and accuracy, especially in low-light or high-optical noise environments, making it an ideal solution for a wide range of applications where light intensity needs to be measured under varying condi...

Dust Control System Using Biocompatible Polymer

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:48:22 GMT

This innovative dust control system utilizes commercially available, cost-effective biocompatible polymers to prolong wettability of beach tailings and contribute to improve Tailings Storage Facility (TSF) management system/stability. Can also be used on Tailing slope, dyke, haul roads, and in coal mining facilities. Background: Conventional dust control methods include implementing a truck-mounted spray system with other toxic polymer additives. The Tailings and TSF dust control additives pose airborne and groundwater health risks to residents living nearby, have high rates of w...

Layout based Grafting Resource Optimizer

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:45:44 GMT

This invention is software that optimizes a factory floor (layout, flow, WIP, etc.) and the number of employees to maximize efficiency of specific factory operations. This system can find the optimum layout design and resource allocation for any agricultural growing facility, although it can be modified for use in facilities in other industries. Not only is this system capable of finding the optimal layout design for such facilities, but it can also find the optimal resource allocation considering the restrictions caused by this layout. Background: Resource allocation and layout design are c...

Method for Line of Sight Bias for Missile Guidance

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:43:13 GMT

This innovation uses a deep learning algorithm to learn a curvature parameterization to apply to the line-of-sight unit vector provided by a missile guidance navigation system. In one implementation the bias is computed using a deep neural network with a recurrent layer which allows the network to predict future target behavior from the history of target behavior during the engagement. The network is optimized using meta reinforcement learning (meta-RL) over an ensemble of engagement scenarios with varying target behavior. Other applications could include spacecraft guidance navigation and con...

Hybrid CV-DV Quantum Communications and Quantum Networks

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:42:25 GMT

This technology is a robust and efficient quantum network that allows for a large number of entangled states to be delivered over the nodes in the network. The network makes use of simultaneous discrete variable (DV) and continuous variable (CV) entanglement unlike existing state of the art quantum networks, making it ideal for serving as the backbone of a quantum internet. Background: Quantum communication networks are important because they provide a higher level of security than traditional communications. To protect traditional communications, encryption is typically applied. But as...

Shape Memory Alloy Tether System

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:42:00 GMT

The shape memory alloy reacts to changes in temperature by changing its initial shape into a predetermined (learnt) shape. This effect can be controlled by the system to perform a progressive envelopment of an intended target in a microgravity environment. The system has no dependency on mechanical components. This avoids system complexity, reduces overall system mass/volume, and keeps power requirements at a minimum. Additionally, as the system only exerts small amounts of force on targets in microgravity, mishandling in the form of unwanted spinning or potential collisions is highly u...

Demonstration of a Two-Bit Controlled-NOT Quantum-Like Gate using Classical Acoustic Qubit-Analogues

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:41:15 GMT

This technology is an implementation of a logic gate using acoustic waves. It is a two-bit controlled NOT gate that allows acoustic waves to be used to perform logic operations like those that can be performed in traditional quantum computers. Background: Controlled NOT (CNOT) gates are quantum logic gates that are fundamental components of quantum computers. For example, it can be used to create entangled states and similarly disentangled states. Traditional quantum computing often requires expensive equipment that suffer from scalability challenges. However, other, newer types of quantum co...

Wearable Wireless Power Supply and Data Communication Device for Small Battery Free Implant

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:40:39 GMT

This is a Near-Field Communication (NFC) enabled technology that can be embedded in wearable materials to charge battery-free implants. It allows for the implants to be charged by power casters from a distance, meaning they remain fully operational 24 hours a day, 7 days a week, for months on end. It will also reduce the space a battery on an implantable device needs. Background: Current battery technology takes up a lot of space, the battery can take up to 90% of the volume of an implantable device and up to 60% of its weight. It is also important to make sure the recharging process does not...

Restricted Area Printing by Ink Drawing (RAPID) for Solution-Processed Thin Films

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:40:10 GMT

Researchers at the University of Arizona have developed Restricted Area Printing by Ink Drawing (RAPID), a novel confined-volume printing technique for solution-processed thin films. This method utilizes confined plates to apply external stimuli, such as temperature and electric fields, allowing for precise control over the crystallization process during film formation. As a result, RAPID improves film quality and enhances scalability for electronics manufacturing. Background: Traditional printing techniques for solution- processed electronics, such as slot-die coating and doctor bladin...

Flyback Echo-Planar Imaging (EPI) Pulse Sequence with Embedded Chemical-Shift and Field Inhomogeneity Compensation Schemes and Artifact-Free Image Reconstruction Procedures

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:38:56 GMT

This technology produces echo-planar imaging (EPI) MRI data free from typical EPI artifact (e.g., Nyquist artifact; chemical-shift artifact; geometric distortion) via two interrelated components. The first is a new algorithm that is used to acquire flyback echo-planar imaging (EPI) data, in which chemical-shift artifact and magnetic field inhomogeneity are inherently encoded in the invented scheme. The second part is an innovative flyback EPI reconstruction procedure, which is capable of generating artifact-free EPI data obtained with the invented acquisition scheme. Background: It is t...

Sequential Control of Electromagnets for CubeSat Docking Attitude Alignment

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:34:39 GMT

The technology is a new method of sequential control of electromagnets in the application of autonomous docking using two CubeSat (miniature satellites). This is done with the help of active illumination signals through LED lights that are installed on two different CubeSats which helps for target identification in both CubeSats. Once the target identification process is done, the runner CubeSat and the chaser CubeSat start to move closer to each other with their propulsion. After the two CubeSats are close enough to each other the lights turn off and a two-step process starts to dock t...

Experimental Method for Manipulation of the State of Multi-Phi-Bit Systems

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:31:09 GMT

This invention is a method to experimentally navigate the Hilbert space of two logical phi-bits. A “phi-bit,” is a two-state degree of freedom of an acoustic wave (an acoustic spin), which can be in a coherent superposition of states with complex amplitude coefficients. Phi-bits are therefore analogues of qubits. The inventors have developed a simple model of the nonlinear array of externally driven coupled acoustic waveguides to shed light on possible mechanisms for the experimentally observed behavior of the logical phi-bit phase. Lastly, the inventors illustrate the ability to e...

A Method for the Practical Implementation of Scalable Quantum-Like Gates using Logical Phi-Bits

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:30:01 GMT

This technology is a breakthrough in the development of acoustic-based (phi-bit based) quantum-analogue computing platform by enabling the design of scalable unitary operations (gates) that do not need to be decomposed into circuits of elementary gates. This should lead to quantum-like information processing approaches that are more effective than those implemented on current quantum computing platforms. Expanding on this innovation, the introduction of acoustic-based mechanisms brings a unique blend of the precision of quantum computing with the adaptability and robustness of classical...

Hostage Negotiator Throw Phone

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:29:29 GMT

This invention is developed to provide a wireless, rugged, two-way audio and video communication system designed specifically for law enforcement Crisis Negotiation Teams. This throwable device enables rapid, remote engagement with barricaded subjects in high-risk scenarios, allowing negotiators to de-escalate crises without hazardous hardwired connections. Unlike traditional systems, the invention integrates a multi-camera array, LTE connectivity, and a laptop-based interface for real-time control, recording and playback. Built for extreme conditions, it enhances officer safety and improves i...

Computer Vision Method for Safety Hazards Detection, Referencing, and Tracking

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:26:50 GMT

This invention is a method for automatic identification and real-time mapping of safety hazards and individuals within underground spaces, such as mines. Using a combination of visual, Near-Infrared (NIR), and LiDAR imaging technologies with a robust, low-cost, machine learning-based algorithm, this innovation captures data and geo-references and categorizes it before transmitting it to a centralized hub for mapping. One of the notable features of this invention is its reliance on collaborative and federated learning, which enables fine-tuning of the machine learning model's parameters and...

Software Architecture Reconstruction from Bytecode

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:21:58 GMT

The Software Architecture Reconstruction (SAR) technology employing bytecode represents a significant advancement in the understanding, maintenance, and evolution of software systems. This innovative approach leverages existing tools used in the creation of self-contained executables for microservices, repurposing and enhancing their capabilities for SAR. The technology generates system-centered views through a methodology implemented in a proof-of-concept tool, utilizing MicroGraal on the Java Platform. The process involves a case study with a third-party microservice system benchmark, produc...

Assessing Microservice System Evolution through Quantitative Reasoning

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:21:35 GMT

The invention addresses the challenges associated with microservices architecture by introducing a novel approach that combines self-contained microservices with centralized assessment methods. While the advantage of microservices lies in their streamlined management and deployment, the decentralized nature of these services often leads to scattered knowledge across the system, making it difficult to comprehend the holistic picture. The technology introduces quantification metrics as indicators for investigating system architecture evolution and reasoning about changes across various versions....

High-Sensitivity Non-Destructive Evaluation/Testing Method for the Detection of Defects in Structures using the Geometric Phase of Acoustic Waves

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:20:13 GMT

This novel, highly sensitive non-destructive testing method analyzes the spacial behavior of acoustic waves to detect cracks and defects in objects and structures, with applications across many industries. This method’s sensitivity allows it to detect even slight flaws and defects, and to identify cracks through topographical complexities like welds and bends. Complexities like these can cause extraneous propagation in waves used for non-destructive testing, creating interference that can hide cracks from many current non-destructive testing methods. This method is less affected by that ...

A Robotic Space Station System for a Modular Surveying Telescope

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:19:12 GMT

This invention outlines a new robotic observation space station concept. It is assembled in space by docking standardized CubeSats with telescope payloads, forming a rotating truss-like structure that is suitable for full sky surveys. Station reconfiguration is incorporated into operations to respond to multi-mission requirements and follow-up observations. The proposed design provides a solution to the cost and complexity of the astronomical survey while introducing additional capabilities. This concept also provides access to underrepresented fields of astronomy and allows for easier access...

Small Satellite Docking Adapter for Power Transfer and Structural Applications

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:14:08 GMT

The invention is a small satellite docking adapter that can be used to assemble larger spacecraft, large structures, and transfer resources such as power. The docking adapter can be used to mate two objects in space that would otherwise be at different angles or are spatially misaligned. The invention also includes a software for CubeSats called Adapter Design And Positioning Tool for Spacecraft (ADAPTS) which is used to design and optimize the locations of docking adapters on spacecraft. Background: Docking systems are critical for various operations such as on-orbit servicing, refueli...

Small Spacecraft & Small Robot Lighting System for Navigation, Identification and Communications

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:12:49 GMT

Spacecraft Optimized Lighting-communications Architecture for Robust Integrated Systems (SOLARIS) is a framework that utilizes advanced lighting and software to enhance communications, tracking, navigation, and security in small spacecraft and robotic systems such as rovers, CubeSats, and more. The framework outlines an entire system to integrate lighting into a spacecraft/space robot. Lighting display formats can be customized and can be connected by wire or wirelessly to host spacecraft or robots. SOLARIS also includes design software that balances design execution on spacecraft, rovers, spa...

Reconfigurable Space Telescope for Long Duration Observations

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:11:43 GMT

This invention is a reconfigurable space telescope with the capabilities of a Schmidt Cassegrain telescope. The invention has deployable structures and mechanisms for optical reconfiguration and is able to switch the focal length of its primary optics, allowing for both wide field surveying and targeted observations for near earth observations and space situational awareness. Application can also be extended to Earth observations for scientific or commercial purposes. The telescope can be packaged within standard CubeSat units, allowing for significant reduction in cost and complexity. Ultimat...

Generalized BEP Relationships for the Prediction of Activation Energies via Machine Learning

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 15:02:21 GMT

At the heart of computational catalyst design lies the construction of a suitable reaction network and the determination of reaction and activation energies for each step for a specific set of, for instance, metals. This technology aims to enable the creation of a sophisticated activation energy predictor / modeler that will enable the investigation and development of chemical reactions through an optimized catalyst. Utilizing machine learning, this technology seeks to revolutionize the catalyst design process by drawing from vast datasets to make more informed decisions. This holistic approa...

Method for On-Chip Squeezed and Entangled Light Generation

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 14:51:05 GMT

Quantum entanglement is as follows: entangled photons for transferring information between two nodes, in which the receiver holds half of the entangled photons while the sender holds the other half. Thus, communication and sensing are made possible by manipulation of these photons and/or observation of the changes of these photons. This invention is a way to generate entangled light via on-chip components. This chip is integrated with microring (ring) resonators which is the component that produces the resonance of light waves. The combination of on-chip interferometers allows for coh...

Low Complexity Memory Decoding and Apparatus for LDPC Codes

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 14:49:55 GMT

This technology presents a new class of finite precision multilevel decoders for low-density parity-check (LDPC) codes. These decoders are much lower in complexity compared to the standard belief propagation (BP) decoder. Messages utilized by these decoders are quantized to certain levels based on the number of bits allowed for representation in hardware. A message update function specifically defined as part of the invention, is used to determine the outgoing message at the variable node, and the simple min operation along with modulo 2 sum of signs is used at the check node. These decoders i...

Zero-Added-Loss Entangled Photon Multiplexing Source

JianlingL@tla.arizona.edu — Tue, 23 Apr 2024 13:30:56 GMT

This technology is a scheme for optical entanglement distribution in quantum networks based on a quasi-deterministic entangled photon pair source. By combining heralded photonic Bell pair generation with spectral mode conversion to interface with quantum memories, the scheme eliminates switching losses due to multiplexing. Based on numerical analyses, the protocol is estimated to achieve >102 ebits per second at memory multiplexing of 104 spin qubits for ground distance >104 km, with the spin-spin Bell state fidelity exceeding 99%. The architecture presents a potential blueprint for rea...

Recovery and Separation of Metals from Aqueous Sources Utilizing Glycolipid Modified Hydrogels and Resins

JianlingL@tla.arizona.edu — Mon, 22 Apr 2024 09:50:29 GMT

This invention describes a methodology for using glycolipid-modified, reusable hydrogels to recover, concentrate, and separate toxic metals from aqueous solutions. Background: Heavy and toxic metal contamination poses a significant risk to human and environmental health in many commercial and environmental settings. Many commercial endeavors in fields such as mining have both a regulatory and business obligation to control toxic metal contamination and reduce exposure to personnel. The inventors have proposed a methodology and formulations for glycolipid-modified, reusable hydrogels an...

Mentoring Best Practices for Faculty and Graduate Students

JianlingL@tla.arizona.edu — Thu, 04 Apr 2024 11:41:07 GMT

This is a professional development training developed by the MENTOR (Mentorship through Effective Networking, Transformational Opportunities, and Research) Institute at the University of Arizona. The purpose is to enhance mentoring practices as a means to improve outcomes such as career advancement, obtaining a great job, timely promotion, academic milestones, and graduation. This training, which was created based on expert consultation with experienced faculty and graduate students across UArizona, integrates best practices from well-established national organizations and was reviewed for acc...

More Green Dots

JianlingL@tla.arizona.edu — Thu, 04 Apr 2024 11:40:54 GMT

More Green Dots is a social-ecological approach to increasing intervention into prosocial interactions, or kindness, using an activity with green and red dots to track kind and unkind behaviors. For kind behaviors, the giver, receiver, and anyone who witnesses the kindness earns a green dot. Red dots are larger than green dots to indicate the negativity bias that causes people to place more weight on negative experiences. At the end of the activity, green and red dots are totaled up to see the “sum” of a person’s experience. It is imperative that a sense of security and belon...

Identification of Inhibitors of Trogocytosis to Treat Cancer

JianlingL@tla.arizona.edu — Thu, 04 Apr 2024 10:38:39 GMT

This innovation is the identification and isolation of small molecules to inhibit trogocytosis to prevent or slow cancer cell tumor growth. Researchers plan to develop cell lines transduced with lentivirus vectors that can be cocultured and the process of trogocytosis will result in cell fusion that will generate a luminescent signal. Selected small molecules with demonstrated inhibition will undergo further studies to validate their functional properties and optimize their structure. The ultimate objective is to develop a drug that can be administered directly into the tumor site through inje...

Transplantable Murine Cutaneous Squamous Cell Carcinoma Cell Lines

JianlingL@tla.arizona.edu — Thu, 04 Apr 2024 10:26:36 GMT

This innovation involves the creation of novel cell lines for studying cutaneous squamous cell carcinoma (cSCC) in mice. These cell lines, derived from UV-induced cSCC tumors in BALB/c mice, recapitulate the mutational signature and driver mutations found in human cSCC. Developing the cell lines from an inbred mouse strain allows for studies involving antigen-specific T cell responses, as the major histocompatibility complex alleles are the same between mice. Additionally, the ability to intradermally transplant the cSCC tumors into mice drastically reduces the length of time needed for experi...

PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function

JianlingL@tla.arizona.edu — Thu, 04 Apr 2024 10:19:38 GMT

This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload, and multiple inflammatory responses. Studies completed by the innovators have shown that the PNA5 treatment reduced infarct size by 35.02% compared to the control-treated animals, decreased regional fibrosis compared to control-treated mice...

Methods of Treating Dilated Cardiomyopathy and Heart Failure

JianlingL@tla.arizona.edu — Thu, 04 Apr 2024 10:06:16 GMT

This innovation is the repurposing of drugs used for testosterone-suppression (androgen deprivation) as an innovative strategy to treat heart failure or dilated cardiomyopathy. These drugs are used for treatment of patients with advanced prostate cancer or for adolescents presenting with precocious puberty. This research is supported by published data demonstrating that surgical suppression of testosterone delays cardiac dysfunction and the progression to symptomatic heart failure (HF), which is defined by edema/congestion. In addition, surgical suppression of testosterone prolongs survival in...

Scattering Based Light Sheet Microscope

JianlingL@tla.arizona.edu — Tue, 02 Apr 2024 13:20:31 GMT

This invention relates to designs of a low-cost scattering-based light sheet microscope that provides microscopic images of human tissue in vivo. The key idea is to use an incoherent line light source with a rectangular aperture to generate light sheet illumination and detect the scattered light from the illuminated tissue plane to generate images. The use of line illumination and rectangular aperture provides a small illumination light sheet width over a large field of view, while reducing the speckle noise and shadow artifacts. This innovative approach towards the design of this microscope ...

Deep Learning Algorithm for Detection of Cortical Arousal During Sleep

JianlingL@tla.arizona.edu — Thu, 28 Mar 2024 13:16:53 GMT

This invention is an end-to-end deep learning algorithm to detect cortical arousals during sleep using a one-night single lead electrocardiogram (ECG) signal. It is used to accurately detect arousal in home sleep tests, by reducing the false negative rate. The model combines both convolutional neural networks (CNN) and recurrent neural networks (RNN). Background: Sleep apnea is a side effect caused by excess weight and obesity, affecting more than a billion people worldwide. Sleep apnea is a ubiquitous sleep-related respiratory disease. Long term occurrences may lead to serious card...

Learn with Harry: A Serious Games Platform and Solution for Training in Mine Safety

JianlingL@tla.arizona.edu — Thu, 28 Mar 2024 13:15:06 GMT

This invention uses an integrated set of software to creatively teach mine safety. Background: Mining inherently involves significant risks to worker health and safety. Traditional courses to mitigate that danger present material in lengthy modules that can fail to fully integrate critical thinking or engagement. The "serious games" approach works to teach vital lessons in a more meaningful and relevant way. This invention improves on previous related work to provide a better user experience and more effective training management. MineSAFE 2.0 updates the stor...

MineSafe: A Software Platform for Serious Games in Mine Safety Education

JianlingL@tla.arizona.edu — Thu, 28 Mar 2024 13:12:32 GMT

InventionMineSAFE is a new approach to mining safety education that goes beyond the traditional approach of seminars and videos. Mine Safe has the capability to place a miner in a simulated environment. Employers will have a variety of pre-packed scenarios to choose from, or may choose to create their own in order to further custom-tailor their safety training. MineSAFE includes several different training initiatives, each with a different focus. The Interactive Fatalgram Simulators focuses on fatality prevention by providing a selection of “minigames” dedicated to teaching the var...

Simulated Equine Radiographic System with Radiographic Images

JianlingL@tla.arizona.edu — Wed, 20 Mar 2024 09:55:50 GMT

This is an educational tool called a Simulated Equine Radiographic Machine (SERM) that helps veterinary students learn how to conduct examination procedures on horses. Students use a device with a display to “scan” a real or dummy horse and practice radiometry procedures. Background: Current technology to help students learn how to do these procedures is nonexistent. Students must go to a clinic with a horse under examination and utilize expensive radiographic equipment and PPE (gowns, gloves, thyroid shields) protection, making it a very expensive and cumbersome process. This inv...

Dispersive Element as a Wavelength Recombiner for AVHF

JianlingL@tla.arizona.edu — Mon, 18 Mar 2024 10:13:59 GMT

This invention is a technique to compensate for the spectral dispersion of the Advanced Volume Holographic Filter (AVHF) using yet another dispersive element. This new element acts as a spectral recombiner and collimate all the different wavelengths. Background: The Advanced Volume Holographic Filter (AVHF) is a holographic system capable of broadband depth-based wavefront selection. The system is composed of two holographic elements: a pre-dispersor (PD) and a volume holographic filter (VHF). The performance of the system can best be characterized by the angular and wavelength selectivity. T...

Phase Modulated Camera

JianlingL@tla.arizona.edu — Wed, 06 Mar 2024 10:05:01 GMT

This invention provides a method to image though a disruptive media, such as fog, rain, snow, and sand particles. The phase-based camera, coupled with existing cameras and sensors normally equipped on autonomous vehicles, allows for detection and viewing objects through fog, smoke, or other atmospheric obstructions. The system consists of a lens, phase light modulation (PLM) device, 2-dimension detector array such as complementary metal-oxide semiconductor (CMOS) imager and a light source, such as a collimated laser, which illuminates the object. Return signal from an object—for example,...

PD-L1 Inhibitors to Mitigate UV-Driven Skin Damage and Cancer

JianlingL@tla.arizona.edu — Wed, 06 Mar 2024 09:11:23 GMT

This innovation is the development of a pharmacological inhibitor of PD-L1 to prevent or reduce the negative impact of acute and chronic solar UV exposure and environmental toxicants on the skin. PD-L1 is a molecule involved in immune regulation and can be upregulated in response to UV radiation and environmental toxins. However, overexpression of PD-L1 can lead to immune evasion by cancer cells and contribute to skin damage. By blocking PD-L1, the immune system’s response can be enhanced, leading to better recognition and elimination of cancer cells and minimizing skin damage. This appr...

An Efficient Method to Estimate Parameters of the Cavity on Integrated Photonic Chips

JianlingL@tla.arizona.edu — Wed, 06 Mar 2024 09:10:29 GMT

This technology is a method for estimating parameters of the cavity on integrated photonic chips. This innovative approach simplifies the estimation process, offering a practical and reliable solution for manufacturers in the industry to help streamline testing procedures. With its simplicity and efficiency, this technology saves valuable time and resources, providing accurate estimations of cavity characteristics without the need for complex fitting processes. The key advantage of this method lies in its ability to distinguish different coupling regimes, resulting in precise calibration of co...

Method and System for Eye Tracking using Deflectometric Information

JianlingL@tla.arizona.edu — Thu, 29 Feb 2024 10:52:35 GMT

This innovation is a new method and system that uses deflectometric information for precise and fast eye tracking, which is a common requirement in current technologies for virtual reality, augmented reality, and mixed reality headsets. Three sub-techniques are used to evaluate the gazing direction including: classical deflectometry, inverse rendering from a virtual eye model, and a deep learning-based method. Other information such as the variances in eye shape and the use of corrective lenses may also be used. The developed method is easy to implement in current VR/AR/MR headsets, and resear...

A Mitochondria-Focused Mouse Model (DRP-1-/- mouse) to Accelerate Gastrointestinal Pathophysiology Research

JianlingL@tla.arizona.edu — Mon, 26 Feb 2024 13:19:59 GMT

This invention is a transgenic DRP-1-/- mouse model that will help address the central role of mitochondrial structure-function dynamics in the mammalian intestine. This mouse model harbors an intestine-specific disruption in DRP-1, a key mitochondrial membrane-associated protein, which will be useful in assessing how mitochondrial structure/interaction influences enteric pathogen disease and basic intestinal cell biology. Specifically, the transgenic mouse can be used by internal and external stakeholders to study gastro-intestinal energetics in the context of infection, nutrition, cancer, me...

A Mitochondria-Focused Mouse Model (OPA-1-/- mouse) to Accelerate Gastrointestinal Pathophysiology Research

JianlingL@tla.arizona.edu — Mon, 26 Feb 2024 13:19:23 GMT

The invention is two engineered OPA-1-/- mouse models that will help address the central role of mitochondrial structure-function dynamics in the mammalian intestine – a translationally critical, but extremely underdeveloped, resource. This mouse models harbor an intestine-specific disruption in OPA-1, a key mitochondrial membrane-associated protein, which will be useful in assessing how mitochondrial structure/interaction influences enteric pathogen disease and basic intestinal cell biology. This can be used by internal and external stakeholders to study gastrointestinal health and dise...

Coherent States Based Quantum Information Processing and Quantum Computing Analogs

JianlingL@tla.arizona.edu — Thu, 15 Feb 2024 11:29:52 GMT

This technology represents a step forward creating a decoherence-free optical quantum information processing and computing analog, which does not rely on the fragile quantum states but rather robust classical states. The inventors propose how to implement the universal set of quantum gates classical analogs in integrated optics by employing classical polarization states derived from the coherent states. This can potentially provide stable qubits analogs for quantum computing, thus potentially reducing the complexity and size of quantum computers. As the quantum qudit alternative authors propos...

End-to-End Test Coverage Metrics for Microservice Systems

JianlingL@tla.arizona.edu — Thu, 15 Feb 2024 11:22:54 GMT

This invention focuses on addressing the challenges that arise in testing microservices architecture, which is known for its cloud-native advantages, scalability, and decentralized development. To tackle this issue, the invention introduces test coverage metrics to evaluate the extent to which end-to-end (E2E) test suites cover microservice endpoints. It also offers an automated method for calculating these metrics, providing feedback on the completeness of E2E test suites. Additionally, a visual perspective is provided to highlight test coverage across the system's microservices, helping ...

Method for Enabling Microservice Architecture Queries and Code Insights Through a New Process Flow enabled by GPT Type Large Language Models

JianlingL@tla.arizona.edu — Thu, 15 Feb 2024 10:26:07 GMT

This invention is in the area of the application of large language models (LLMs), like ChatGPT, to improve the comprehension of microservice architecture within the software domain. Microservices offer flexibility and scalability but can be complex to understand, particularly when dealing with Enterprise Architecture documentation from different teams. This invention improves ChatGPT's ability to answer intricate queries related to cloud-native systems by using both source code and an intermediate representation obtained from static code analysis. Specifically, it addresses questions relat...

Distributed Computer Processing Networks for Lunar Bases and Space Stations

JianlingL@tla.arizona.edu — Mon, 12 Feb 2024 09:15:09 GMT

This invention comprises systems and methods for a hyper-redundant distributed computing and communication network that can permeate base infrastructures and heal from local damage. Modular components are used to collect, process, store, and communicate information in a distributed fashion. The networks can make localized decisions independently and offload routine maintenance responsibilities from astronauts, improving the efficiency of base operations and overall safety. This software can be implemented as a control architecture and ecosystem for smart bases (military, army, commercial, etc....

Advancing Utilization of Swarms for Sample Return and Multipoint Observation Using Inflatables

JianlingL@tla.arizona.edu — Mon, 12 Feb 2024 08:26:22 GMT

This technology is a system and method for an attachment to a mothership/craft or “bus” that uses space or ground-based inflatable structures to capture entire swarms of autonomous spacecraft, air, or unmanned aerial system (UAS) drones. A bell flower-like geometry is used for its ability to capture an incoming vehicle with randomized conditions and trajectories due to running out of fuel or damage to propulsion or guidance, navigation, and control (GNC) systems. Background: Inflatable systems have widespread applications in the aerospace and astronautics industries as habit...

Metabolic Screening Methods for Endometrial Cancer

JianlingL@tla.arizona.edu — Thu, 08 Feb 2024 09:46:23 GMT

Researchers at the University of Arizona employed cervicovaginal lavage sampling and a global untargeted metabolomic approach to identify potential biomarkers for endometrial cancer. The study's novel approach involved linking cervicovaginal metabolite levels to crucial tumor characteristics such as size, histological grade, and myometrial invasion, which are essential for risk stratification of endometrial cancer patients. The findings, when combined with previous research, offer a promising avenue for enhancing diagnosis and a deeper understanding of the metabolic reprogramming associate...

Multifunctional Nanofiber Reinforcement for Printable Electronics

JianlingL@tla.arizona.edu — Tue, 06 Feb 2024 16:25:07 GMT

Researchers at the University of Arizona have integrated electrospun nanofibers into printable optoelectronic films to improve their stability and toughness. These nanofibers have the potential for improved efficiency in solar cells through light scattering. Background: Recent advances in the solar cell industry have led to the development of more efficient construction materials for solar cells. Perovskite-based solar cells have been competing with the best silicon-based photovoltaics due to their ability to exhibit greater efficiency than silicon-based ones. Even though Perovsk...

Pulsed Laser with Temporal Coherence Control

JianlingL@tla.arizona.edu — Tue, 06 Feb 2024 10:07:21 GMT

This technology is a solid-state substitution of excimer lasers, specifically the ArF laser. The technology is suitable for lithography use and for the manufacturing of semiconductors. This approach will alleviate technical issues with current technologies in semiconductor manufacturing approaches. The technology uses a cascading system to reach the target ultraviolet wavelength in order to work with the semiconductor materials. Background: In the semiconductor manufacturing industry, ultraviolet lasers are utilized to work with these materials. However, there are technical issues...

Fluorinated Poly (β-Amino Ester) Nanoparticle for Highly Efficient and Specific Delivery of Nucleic Acids to the Lung Capillary Endothelium

JianlingL@tla.arizona.edu — Tue, 06 Feb 2024 09:24:06 GMT

This technology describes nanoparticles with specific structure design and modification for high efficiency and specific delivery of nucleic acids to the pulmonary endothelial cells. After intravenous administration, the nanoparticles were capable of delivering non-integrating DNA plasmids to lung microvascular endothelial cells but not to other lung cell types. Hematologic analysis and liver and kidney metabolic panels demonstrated the lack of toxicity in experimental mice. Thus, these nanoparticles can be an ideal vehicle for gene therapy targeting lung microvascular endothelium in pulmonary...

Broad Applications of PROTACS for Targeted Protein Degradation Employing a Molecular Glue-Linker-Warhead Approach

JianlingL@tla.arizona.edu — Tue, 06 Feb 2024 09:17:40 GMT

This technology is a high-affinity E3-ligase binder, which has been optimized toward the specific proteolysis targeting chimera (PROTAC) mediated degradation of particular proteins. A PROTAC is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. This technology opens the door for the treatment of diseases and conditions otherwise thought to be untreatable or undruggable. Background: Once a target protein is identified as being associated with a disease, traditional drug discovery strategies have centered around...

Polar Wall for Indoor Farming: Low-Cost Cooling for Indoor Farms

JianlingL@tla.arizona.edu — Thu, 01 Feb 2024 13:17:00 GMT

Invention: University of Arizona researchers have developed a novel, low-cost system designed for cooling the ambient air inside an indoor farm, such as a greenhouse, vertical farm and/or module-type farm. It consists of a freezer box — ideally solar powered — that freezes reusable ice packs arranged in different configurations within the box. The freezer may be attached to a wall of an indoor farm or it may be free standing with the capability to move. The polar wall will forgo a cooling process that repeated in cycles to freeze the reusable ice packs. The indoor farm is also equi...

Chemistry by Design

JianlingL@tla.arizona.edu — Mon, 29 Jan 2024 08:49:58 GMT

Title: Chemistry by Design Invention: This invention is a custom database of worldwide approved pharmaceutical structures, including the United States FDA, that are available for use via a commercial app. Background: Any substance, or mixture of substances, that is planned to be an active ingredient for a drug product is classified as an active pharmaceutical ingredient. The finished dosage form is classified as a drug product. Currently, Thieme has a commercial drug database for synthesis of drug molecules, however, its price, appeal and design are problematic. This invention overco...

Arch Reactivator

JianlingL@tla.arizona.edu — Thu, 25 Jan 2024 14:11:44 GMT

This technology is a dynamic brace that incorporates spring-based mechanisms to address degenerative flat foot, a condition characterized by arch collapse. Unlike static braces, this solution harnesses the power of energy storage to act as a conduit for dynamic motion and propel the wearer forward, effectively transforming each step into a responsive spring-like motion. The technology not only addresses the physical challenges of degenerative flat foot but also returns energy to the user’s gait, empowering individuals with a renewed freedom of movement and an invigorating sense of propul...

Engineered Sorbents and Process for Selective Removal of Perfluorinated Organics Species from Water

JianlingL@tla.arizona.edu — Fri, 19 Jan 2024 13:26:21 GMT

This technology represents a new chemical process for selective removal of greater than 90% of the perfluorinated organics (PFAS) from contaminated water per pass through a sorption stage. The separation media comprises a selective surface modifier, with tunable properties, incorporated on an inexpensive material, which may be a cellulose sponge, fiber, or powder. Background: Perfluorinated organics are very stable manmade chemicals that have properties that allow them to repel both water and oil. PFAS are often referred to as “forever chemicals” because they do not readily ...

Method, System and Device for Water Conservation and Dialysate Recycling

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:30:01 GMT

The technology is a method to recycle water that is used during dialysis. By using activated charcoal, urease, zirconium oxide and zirconium phosphate to filter the water of contaminants, this method can make water achieve a purity level that is acceptable for clinical reuse. As dialysis becomes an essential treatment for an increasing number of patients globally, the need for water conservation in the process is paramount. By allowing water to be recycled for clinical reuse, this technology not only contributes to environmental sustainability but also ensures a steady supply of purified wate...

New Deuterated Amino Acid Derivatives

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:29:53 GMT

Compositions and methods of making involve the use of alternative acids as reactants instead of carboxylic acids, which produce deuterated amino acids, while carboxylic acids can only synthesize alkyl amino acids. Introducing deuterium to amino acids and derivatives improves biologically active compounds and therapeutics. Modification improves properties such as metabolic stability and minimizes racemization in peptide and peptidomimetic therapeutics to enhance performance. Background: Existing procedures for production of deuterated amino acids have problems including issues with selec...

Phenyllactic Acid: Antimicrobial Activity against Vaginal Microbiota and Cytotoxic Properties on Human Cervical Epithelial Cells

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:24:09 GMT

Researchers at the University of Arizona investigated the antimicrobial properties of Phenyllactic Acid (PLA) derivatives against both commensal and Bacterial vaginosis (BV)-associated bacteria, as well as their cytotoxic effects on human cervical epithelial cells. PLA is a broad-spectrum antimicrobial compound produced by vaginal Lactobacillus species; however, its mechanisms and functions within the cervicovaginal microenvironment are not well understood. To address the solubility issue of PLA, the researchers synthesized PLA ionic liquids (ILs) using choline and carnitine counterions, which...

Methods and System for Closed-Loop Ultrasound and Photoacoustic Imaging

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:21:45 GMT

This technology is a novel closed-loop volumetric ultrasound and photoacoustic imaging and spectroscopy method that is operator-independent. The technology can be integrated with existing hardware systems, and it offers the flexibility to scale from standard clinical ultrasound to high-frequency preclinical imaging for visualizing structures at different scales. This method also offers enhanced contrast and information by combining ultrasound and photoacoustic imaging modalities and enables multi-dimensional imaging by integrating light and sound. This exciting new technique has unique ...

Polymeric Valve for Tricuspid Applications

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:14:42 GMT

This invention is a medical implant that is made of polymeric and metallic materials, which functions as a replacement valve for tricuspid applications. The valve functions as a flow regulator and can be installed in low-pressure, low-flow and low-shear cardiovascular structures. It is specifically engineered to reduce stress on the implant structure as well as to reduce and minimize stress imparted on overflowing fluid, such as blood. Background: Treatment of severe tricuspid regurgitation poses a significant challenge, with considerable risks and medium-term outcomes. The current meth...

Bioorthogonal Activation of PROTAC Prodrugs

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:11:32 GMT

Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and a cancer biomarker integrin-targeted ligand for targeted release of the PROTAC prodrugs, resulting in selective degradation of proteins of interest (POIs) in cancer cells while sparing normal cells. This approach allows for precise control over t...

Rotational Force-Induced Brain Injury Model

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:09:58 GMT

This innovation is a new instrument, model, and treatment for repetitive rotational head trauma in rodents that demonstrates the acute and prolonged pathological, behavioral, and electrophysiological effects of rotational traumatic brain injury (rTBI). Aberrant Cyclin-dependent kinase 5 (Cdk5) activity is a principal mediator of rTBI. Cdk5-enriched phosphoproteomics is used to uncover potential downstream mediators of rTBI and show that pharmacological inhibition of Cdk5 reduces both cognitive and pathological consequences of injuries. Background: Millions of traumatic brain injur...

Methods for Guiding Treatments of Vulvovaginal Symptoms and Female Sexual Dysfunction

JianlingL@tla.arizona.edu — Tue, 16 Jan 2024 09:08:31 GMT

Multi-omics analysis of cervicovaginal samples has led to the identification of a specific immune mediators, metabolites, and bacteria that are associated with vulvovaginal and sexual health symptoms. These biomarkers hold the potential to be utilized in a non-invasive test that guides the treatment of vulvovaginal symptoms and female sexual dysfunction in both pre- and post-menopausal women. These genitourinary symptoms encompass various issues such as dryness, irritation, painful intercourse, and pain during urination. Based on the test results, appropriate personalized treatments can be det...

Method of Determining the Microstructure of Additively Manufactured Metallic Materials using In-Situ Process Monitoring Data

JianlingL@tla.arizona.edu — Fri, 12 Jan 2024 13:55:28 GMT

The technology is a method that can improve additive manufacturing by actively monitoring the deposition of materials. In this novel method, the in-situ monitoring data plays a critical role in enhancing the understanding and control of microstructural development during the printing process. By leveraging this data, the technology can dynamically adjust the additive manufacturing parameters in real-time to optimize the microstructure of the final product. This allows for greater precision in achieving desired mechanical properties and reduces the risk of defects while increasing production ef...

Wavelength Diversity based Low Probability to Intercept (LPI) Free-Space Optical Communications in Strong Turbulence Regime

JianlingL@tla.arizona.edu — Fri, 12 Jan 2024 13:54:02 GMT

This technology uses an encoded broadband source on two different center wavelengths on different balanced detectors simultaneously to provide low probability for intercept communications for Free Space Optical communications and defense applications. Experimental results demonstrated success using wavelength diversity together with LDPC coded modulation to deal with strong atmospheric turbulence effects. This technology represents a low-cost solution to deal with atmospheric turbulence effects compared to high-cost adaptive optics. Background: The field of free-space optical (FSO) comm...

Entanglement Assisted Sensing and Radars with the Phase-Conjugation on Idler Photons

JianlingL@tla.arizona.edu — Fri, 12 Jan 2024 13:53:44 GMT

This innovation is a concept suitable for various quantum sensing and radar applications. The proposed entanglement generation source and optical-phase conjugation modules are of low-cost and easy to integrate in photonic integrated circuit (PIC) technology. These quantum sensing modules and architectures are suitable for use in entanglement assisted (EA) sensing and radar applications. To improve the reliability over turbulent optical channel, researchers performed the Optical Phase Conjugation (OPC) on idler photons. Background: Phase conjugation of Signal Photons has been a requireme...

Machine Learning Protocol to Improve Clinical Diagnosis, Prognosis and Disease Subtyping for Spectrum Disorders

JianlingL@tla.arizona.edu — Wed, 10 Jan 2024 14:28:54 GMT

This innovation is a proposed machine learning-based software designed to improve diagnosis, prognosis, and clinical management of rare diseases, a category encompassing over 10,000 conditions with new additions each year. Currently, the field grapples with a scarcity of effective solutions, with only 5% of rare diseases having established therapeutic options. This innovative approach would leverage individual genotypic, phenotypic, and medical data to unravel the complexities of rare diseases, classify patients into distinct endotypes, and identify predictive risk factors for tailored therape...

The Statewide Mobility Analytics in Real Time Tool

JianlingL@tla.arizona.edu — Wed, 10 Jan 2024 14:28:01 GMT

The Statewide Mobility Analytics in Real Time (SMART) Tool is a web-based platform for managing transportation data. Leveraging cutting-edge data analysis and visualization techniques, this suite enables users to gain valuable insights into the intricacies of traffic patterns, congestion points, and overall vehicular movement. By aggregating and processing real-time data from various sources such as sensors, cameras, and GPS devices, the tools provide a holistic view of the entire traffic ecosystem. One of the distinctive features of this invention is its ability to not only diagnose existing ...

Tributyrin to Entain Human Circadian Rhythms and Improve Sleep in Individuals with Medical Disorders that can Increase Gut Permeability or Elevated Levels of Systemic Inflammation

JianlingL@tla.arizona.edu — Wed, 10 Jan 2024 09:18:34 GMT

This documents a new method of treatment for sleep improvements. Poor sleep is likely manifested by an underlying irregular circadian rhythm sleep disorder. A patient with a history of leaky gut syndrome and poor sleep took a commercially available oral short-chain fatty acid supplement, tributyrin, and documented improved sleep. This suggests a relationship of the gut microbial axis and its influence on the circadian network regulation and intestinal epithelial homeostasis. The patient reported better consolidated sleep while a delayed sleep phase phenotype remained. The favorable effect of s...

Human Serum Albumin-Transgenic Mouse

JianlingL@tla.arizona.edu — Wed, 10 Jan 2024 09:14:50 GMT

A novel human albumin transgenic mouse model was developed which can be used to establish human protein biomarkers of exposure to hazardous xenobiotics for human risk assessment via animal studies. This can provide a unique in vivo tool for the assessment of risks of toxicity associated with human exposure to environmentally hazardous chemicals and therapeutic drugs, using human albumin as a protein target. The researchers developed an alternative approach to the measurement of DNA adducts for assessing human exposure to hazardous chemicals through biomonitoring of protein-carcinogen adducts. ...

Small Molecules with Antifungal Activity for Cryptococcosis

JianlingL@tla.arizona.edu — Wed, 10 Jan 2024 09:12:02 GMT

Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic fungal pathogens Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga). Immunocompromised individuals are the most affected. Approximately 223,100 human patients are affected by cryptococcosis meningitis globally, with 18...

UV-Curable Thiol-ene System for Broadband Infrared Transparent Objects

JianlingL@tla.arizona.edu — Wed, 10 Jan 2024 08:15:58 GMT

This invention is a UV-curable Thiol-ene system that marks a significant advancement in the production of infrared (IR) transparent materials. This solution harnesses an original thiol-ene strategy, which employs a meticulously designed combination of multithiols and divinyl oligomers (DVO). These components are exclusively comprised of C, H, and S atoms, ensuring a distinct level of transparency across a wide spectrum, from visible light all the way to long-wave IR (LWIR). This comprehensive approach empowers a more effective production of IR transparent objects, bolstering efficiency while p...

Ultra-Sensitive, Selective, and Humidity Resistant Detection of Nitric Oxide

JianlingL@tla.arizona.edu — Tue, 09 Jan 2024 11:09:50 GMT

This invention is a Whispering-Gallery Mode (WGM) microtoroidal optical resonator designed for ultra-sensitive detection of nitric oxide gas, achieving remarkable precision with a detection limit as low as 2.34 parts per trillion (ppt). This exceptional sensitivity is achieved through the utilization of ferrocene-containing polymeric coatings created via RAFT polymerization, which enhance selectivity for the target analyte, nitric oxide. The system, known as the Frequency Locked Optical Whispering Evanescent Resonator (FLOWER), tracks the real-time shifts in resonance with sub-femtometer resol...

A Broad Spectrum Antimicrobial that Synergizes with Copper

JianlingL@tla.arizona.edu — Fri, 05 Jan 2024 15:46:29 GMT

University of Arizona researchers have developed an invention that synergizes with copper to kill and prevent further growth of a broad spectrum of pathogens (i.e both Streptococcus pneumoniae and Valley Fever with the potential to work on other pathogens). This therapy does not allow for resistance to be built by the microbes. Published paper with mouse model data available at https://journals.asm.org/doi/full/10.1128/Spectrum.00778-21. Background: Streptococcus pneumoniae is bacteria that causes meningitis, sepsis, ear infections, and pneumonia. Due to increas...

High-Throughput 3D Printing System

JianlingL@tla.arizona.edu — Wed, 20 Dec 2023 12:16:02 GMT

This invention is a high-throughput 3D printing system that employs a multi-head configuration, complemented by custom objectives designed for an expanded field of view (FOV). This approach uses a custom-designed microscope objective with expanded FOV for greater accuracy during production. The system results in a significant increase in 3D printing throughput, enabling greater production efficiency and speed, and improving the current state of 3D nano-printing technology (two-photon polymerization, or TPP). Background: The current two-photon polymerization (TPP) printing method h...

Incoherent Light Sources-Based Low Probability of Detection and Covert Radars over Atmospheric Turbulence Channels

JianlingL@tla.arizona.edu — Thu, 14 Dec 2023 10:58:47 GMT

This technology is a low probability of detection (LPD) /covert radar concept that employs incoherent, broadband light sources. The main idea is to hide the radar signal in solar radiation while employing constant amplitude modulation schemes at high-speed to detect the presence of the target via cross-correlation method. The technology has been tested in a practical scenario through an outdoor free-space optical (FSO) testbed developed at the University of Arizona campus, enhancing its feasibility with real-world applications. The implementation of adaptive optics has been introduced to coun...

AI-Based Synthetic Generation of Radio-Frequency Maps in Wireless Communication Systems

JianlingL@tla.arizona.edu — Thu, 14 Dec 2023 10:47:38 GMT

This technology is a novel, cost-effective method which creates radiofrequency (RF) maps used in wireless communication. The improvement is that this technology can use previous RF maps as inputs and with the help of sophisticated artificial intelligence, produce new areas or new capabilities with the requirement of significant field measurements. This inventive method presents a valuable solution for efficiently generating RF maps and overcoming the complexities associated with site surveys, ray tracing, and other existing techniques. This technology can be used in any type of synthesizing he...

Hadamard Transform-Charge Detection-Mass Spectrometry

JianlingL@tla.arizona.edu — Thu, 14 Dec 2023 10:43:11 GMT

This technology uses a multiplexing approach to online size exclusion chromatography (SEC) coupled with Orbitrap CD-MS. A microcontroller is used to deliver pulsed injections from a large sample loop onto a SEC for online CD-MS analysis. The method produces a series of peaks spaced according to the pseudo-random injection sequence, which are demultiplexed with a Hadamard transform algorithm. This improves CD-MS signals while preserving the retention time information. This multiplexing approach provides a general solution to the inherent incompatibilities of online separations and CD-MS detecti...

Redox-Activated Pro-Chelators

JianlingL@tla.arizona.edu — Thu, 14 Dec 2023 10:23:04 GMT

Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate into iron chelating agents within the reducing environment of the cytoplasm of cancer cells. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion dysregulation. The pro-chelator...

Herbostroiodine: An Herbal-Based Radioprotective Drug Against I-131 and Sr90 Radioactive Elements with Dual Actions

JianlingL@tla.arizona.edu — Thu, 14 Dec 2023 09:58:05 GMT

Herbostroiodine is an innovative herbal extended release radioprotective drug formulated with a multilayer noisome carrier. Its composition includes natural products. The use of noisome as a carrier enhances oral bioavailability and allows for the simultaneous delivery of both hydrophobic and hydrophilic agents. Herbostroiodine exhibits dual-action by chelating and removing radioactive elements like I-131 and Sr90 from the body while mitigating their adverse effects. It surpasses conventional radioprotective drugs, such as potassium-iodine, in effectiveness and safety, with minimal side effect...

Probabilistically Coded Modulation Formats for 5G Mobile Fronthaul Networks

JianlingL@tla.arizona.edu — Tue, 12 Dec 2023 12:29:53 GMT

The invention proposes a three-level probabilistically coded pulse amplitude modulation (PAM-3), and a five-point quadrature amplitude modulation (QAM-5) schemes in hybrid mobile fronthaul (MFH) networks that support both direct and coherent detection. Background: The emergence of the next generation of cellular networks (5G) can support disruptive applications and services. These include smart city infrastructure, autonomous driving, and augmented/virtual reality. The deployment of the technology requires for up to 1,000 times higher traffic rates, lower-end-to-end latencies, higher re...

Compact, Lightweight Counter for Atmospheric Cloud Condensation Nuclei and Condensation Nuclei

JianlingL@tla.arizona.edu — Wed, 06 Dec 2023 08:23:20 GMT

This technology details a lightweight integrated analysis instrument for dual use to directly sample, analyze, and count atmospheric cloud condensation nuclei and/or condensation nuclei. The instrument can be operated in dual modes: as a Cloud Condensation Nucleus Counter (CCNC) and as a Condensation Nucleus Counter (CNC). An integrated prototype fits in a portable, lightweight bag, and directly draws in atmospheric samples into an analysis chamber to count either cloud condensation nuclei or condensation nuclei, depending on this setting is selected. Measurements are then displayed and ...

Solid Set Flood Irrigation

JianlingL@tla.arizona.edu — Tue, 14 Nov 2023 13:15:25 GMT

This invention is a solid-set irrigation bubbler head sprinkler system designed to replace existing low-output sprinkler heads commonly used in agricultural fields. The design of the system directs the water downward to guide it toward the soil while simultaneously controlling the flow to prevent soil erosion. This innovation allows for more precise flooding of fields and precise fertilizer applications. The solution devised by the team at Yuma County Cooperative Extension promises to significantly improve the efficiency of flood irrigation for secondary crops, leading to more sustainable and ...

Smart EVD System

JianlingL@tla.arizona.edu — Wed, 08 Nov 2023 12:27:52 GMT

This invention is a smart system for the collection of cerebrospinal fluid from an external ventricular drain (EVD) that can automatically adjust the height and intercranial pressure of a patient. The invention will use a cerebrospinal fluid (CSF) flow sensor, a way to determine the position of the patient and the collection vessel, and an actuator that can automatically adjust the position of the collection vessel to compensate for any motion of the patient to help maintain the patient’s intercranial pressure. This can also determine the actual flow of CSF and adjust the height of the c...

Reflective Objective Microscope

JianlingL@tla.arizona.edu — Tue, 07 Nov 2023 09:44:16 GMT

The invention is an all-reflective microscope with the unique characteristic that has an off-axis configuration with freeform surfaces. This configuration was not possible in the past due to the limitations in the design, fabrication, and testing of freeform optics. By integrating freeform optics in an off-axis setup, this design increases the efficiency and also addresses challenges associated with conventional microscope optics, such as chromatic aberrations and group delay dispersion. It marks a significant step forward in leveraging the full potential of freeform surfaces. Background:&nbs...

3D Printing of Anisotropic Material with Tunable Electric and Magnetic Field

JianlingL@tla.arizona.edu — Tue, 07 Nov 2023 09:38:45 GMT

This invention proposes a new method and print head design to manufacture complex 3D structures by using anisotropic materials. The technique consists of controlling both the shape and alignment of the anisotropic material by using applied electric and/or magnetic fields. With this method an object can be created layer by layer with different materials by spatially varying the anisotropy of the materials. The most common applications where this new 3D manufacturing method and print head design includes industrial manufacturing, prototyping, arts, and optics. Other applications where the manuf...

Gaussian Boson Sampling to Accelerate NP-Complete Vertex-Minor Graph Classification

JianlingL@tla.arizona.edu — Tue, 07 Nov 2023 09:38:06 GMT

This invention is a new classical algorithm used to classify if two graphs are vertex-minor equivalent or not, an NP complete problem which improves on prior results using currently published well-known classical algorithms. The inventors also introduce a new classical algorithm based on graph spectra that outperforms other classical algorithms and demonstrate that, on reasonable assumptions of loss and squeezing parameters, this quantum algorithm performs better than classical algorithms. Furthermore, the innovative approach of combining classical and quantum methods presents new possibilitie...

Dual-View Microscope

JianlingL@tla.arizona.edu — Tue, 07 Nov 2023 09:35:04 GMT

A new type of microscope objective that integrates simultaneous co-axis low-resolution wide field of view (FOV) imaging with high-resolution small field of view imaging. A waveguide is used to relay the pupil of the wide field of view imaging system to the axis of the objective. The system addresses limitations of state-of-the-art microscope objectives and is particularly useful for biomedical and cancer imaging. Background: Optical microscopy is a key tool in biomedical and cancer imaging because it offers several ideal features for imaging cells and tissue structure. For example, (1) ...

Joint Space Quantification of Multiple Carpal Bones of Wrist-based on 3D Imaging

JianlingL@tla.arizona.edu — Thu, 02 Nov 2023 13:18:17 GMT

This technology is a software that is able to calculate the distance between joints among the carpal bones using 3D imaging, such as CT scan or MRI. Traditional joint space distance is calculated in a single joint for example the knee in 2D or 3D. The wrist has 8 carpal bones and forms many joints, and it is novel to quantify the joint space among these joints. Background: According to the CDC, 58.5 million US adults (1 in 4 individuals) suffer from arthritis and oftentimes limits their ability to work. However, through the use of this software, the ability to properly diagnose disorders of w...

Fluorophore-Doped Metal-Organic Frameworks for Quantifying Low-Energy Radionuclides in Aqueous Solutions

JianlingL@tla.arizona.edu — Thu, 02 Nov 2023 12:24:09 GMT

This technology represents a new class of scintillation materials based on metal organic frameworks (MOFs), highly crystalline and tunable structures, which may provide higher detection efficiency compared to other particle scintillation materials. Furthermore, the use of fluorophores with these MOFs paves the way for more versatile applications in the realm of radioisotope detection. The unique combination enhances signal clarity, reducing background noise and increasing overall sensitivity. This breakthrough has the potential to revolutionize methods and protocols in research fields requirin...

Situational Environment for Programming & Scripting (SEPS)

JianlingL@tla.arizona.edu — Wed, 01 Nov 2023 11:13:27 GMT

Situational Environment for Programming & Scripting (SEPS) is a hybrid cloud-based programming & scripting platform designed to deliver a world class learning experience for students developing critical capabilities needed to support our cyber security, cyber operations, incident response, and digital investigations infrastructure. SEPS will provide students with a hands-on interactive experience where they are challenged to develop and deploy software and solutions that interact directly with existing and future CyberApolis worlds. Students will develop programs, scripts, and solution...

StellarScape - Immersive Multimedia Performances, Experiences, and Installations

JianlingL@tla.arizona.edu — Wed, 25 Oct 2023 11:09:23 GMT

StellarScape is a combination of music, dance, and cinematography, blended with state-of-the-art data visualization and astrophysical simulation. StellarScape is not only an immersive multimedia performance synthesizing music, science, visual art, and technology, but also an interactive audiovisual installation/experience that allows the visitors to touch the stars using their motion. StellarScape is the fusion of art, science, and technology, and shows that computers can be harnessed to create complex and evocative works of music, while using technology to display the grace of human movement ...

Error Correction System and Method

JianlingL@tla.arizona.edu — Wed, 18 Oct 2023 14:16:46 GMT

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Peptides to Treat SARS-CoV, Pulmonary Hypertension and other Pulmonary Vascular Diseases

JianlingL@tla.arizona.edu — Wed, 11 Oct 2023 15:43:11 GMT

This innovation is centered around a peptide designed to interrupt the action of a protein called Aminopeptidase N (APN). This peptide functions as an antagonist or inhibitor, binding to the intracellular portion of APN. The primary focus of this technology is to treat pulmonary arterial hypertension (PAH) and viral infections, including COVID-19. PAH is a severe cardiovascular disease characterized by thickening of the pulmonary arteries due to uncontrolled proliferation of smooth muscle cells, leading to right ventricular hypertrophy and failure. The technology aims to target the causal prot...

A Method of Treating Fibrosis and Cancer across Organ Systems

JianlingL@tla.arizona.edu — Wed, 11 Oct 2023 11:16:05 GMT

This technology is directed to a method of treating fibrosis and cancer by targeting circulating cells. Researchers identified mechanoresponsive myeloid subpopulations present in fibrotic and healthy tissue. Certain subpopulations of circulating cells have been implicated in the processes of cancer and fibrosis. These subpopulations are subsequently modulated by manipulating mechanical strain in vivo and in vitro and find that specifically targeting a certain type of signaling is sufficient to reduce the pro-fibrotic subpopulations and instead restore the native, anti-inflammatory subpopulatio...

High-Speed Confocal Microscope

JianlingL@tla.arizona.edu — Wed, 04 Oct 2023 11:15:03 GMT

This invention describes a design and method for a high-speed, low-cost confocal microscope for cellular visualization of human tissues in vivo at microscopic resolution. It will be able to visualize cellular features associated with human diseases. Background: A confocal microscope is a kind of fluorescent microscope used to obtain high-quality 2D and 3D images. Products that produce these types of diagnostic images are extremely pricey. An average service contract for a device is around $120,000 USD. The technology would be used to develop a low-cost confocal microscope for diagnos...

Method and Device for Synthetic Light in Flight Imaging

JianlingL@tla.arizona.edu — Wed, 04 Oct 2023 10:46:50 GMT

This invention is a method that enables light in flight imaging using only continuous wave (CW) lasers and an inexpensive off-the-shelf CMOS/CCD camera. This method exploits a specific algorithm that allows one to computationally shape the pulse via post-processing in the computer. By freely controlling the phase and amplitude of each single monochromatic field in the pulse, one can also create other shapes (e.g., double pulses), that can be then precisely tailored to specific applications - all software sided and in post processing without acquiring new data. Background: In the 1970s ...

Bio-Engineered Human Prostate Disease Model

JianlingL@tla.arizona.edu — Wed, 04 Oct 2023 10:43:08 GMT

This invention is an in vitro human prostate disease model that utilizes microfluidic Organ-on-Chip technology. The model comprises multiple compartments separated by porous membranes, allowing for the co-culturing of essential tissue types involved in prostate diseases. It provides a physiologically relevant environment and enables communication among the different tissue types. This prostate disease model offers a wide range of applications. It can investigate various aspects of prostate disease, including tumor progression and invasion into healthy tissues within the organ and other organs....

Perceptual-Driven Foveated Optical See-Through Head-Mounted Displays

JianlingL@tla.arizona.edu — Wed, 04 Oct 2023 10:16:43 GMT

This invention consists of the design and embodiments of a statically optical see through head-mounted displays (OST-HMDs) in which the angular pixel density decreases with the increase of the filed eccentricity according to a specified angular pixel density function. To facilitate the head-mounted display capability to simultaneously see the image rendered by a display and the view go the real-world scene, a freeform prism is utilized as the optical combiner to merge the optical paths of the virtual image display and real-world view. The implementation of the described features creates...

Lensfree Microscopy for Ultrafine Particulate Matter Monitoring

JianlingL@tla.arizona.edu — Wed, 04 Oct 2023 09:34:23 GMT

This system monitors ultrafine particulate matter and pollution in the air using compact, inexpensive, and portable devices, which enable time-resolved measurements particle sizes. It could be used to implement a dense network of devices, which provide ultra-precise real-time monitoring of air content and quality levels. Background: Particulate matter 100 nm and smaller is “ultrafine” particulate matter, which is particularly hazardous to human health despite not being widely monitored like “fine” particulate matter, which is less than 2.5 um in size. Lensfree microsco...

Concentrated Solar Receiver and Reaction Chambers for Hydrogen Production using Solar Energy

JianlingL@tla.arizona.edu — Mon, 02 Oct 2023 15:01:01 GMT

This technology is a solar receiver tower that has a set of reciprocally rotatable chambers that receive different amounts of solar energy at the tower. This differentiates the temperatures of each chamber to house different stages of thermochemical reactions for hydrogen production. Using solar energy to produce hydrogen for fuel is a solution for long-term solar energy storage. Background: The problem with current technologies for producing hydrogen fuel is that they are not sustainable, efficient, or cost-effective. Traditional hydrogen production methods, such as steam reforming and...

Force Sensing System for Surgical Self-Retaining Retractors

JianlingL@tla.arizona.edu — Mon, 02 Oct 2023 13:41:08 GMT

This invention is a single self-retaining retractor with an autoclave force sensor mounted on each side of the retractor at the tissue interface. A force sensor is connected to a processing circuit via autoclave wires and a thermocouple. The processing circuit is connected via a Bluetooth low energy (BLE) with a mobile application to display store and share the data that has been collected. The app also alerts the user if the programmed force threshold has been exceeded. The sensor subassembly portion is sterilizable via autoclave. This system can provide valuable feedback to surgeons o...

Wide Area Spectralelectrochemical Measurement of Thin Film Semiconductors for Electronic Band Structure Analysis

JianlingL@tla.arizona.edu — Thu, 28 Sep 2023 16:35:23 GMT

This invention is a rapid, nondestructive detection method for properties of semiconductor stacks (including perovskite stacks for use in photovoltaics) which can be used at speeds and scales relevant for manufacturing to check product quality. This invention could reduce/remove barriers for manufacturing scale-up and production of high quality robust next generation photovoltaics. Background: The physical properties and chemical characteristics of perovskite thin films and their contact interfaces are complex and defects arising in these materials may be stochastic. Very sophisticated ...

Method to Predict, Evaluate and Map Soil Microbial Function for Broad Geographical Regions using Omics and Machine Learning

JianlingL@tla.arizona.edu — Thu, 28 Sep 2023 16:20:19 GMT

This invention is a method for predicting and geographically mapping the functional composition of soil microbial communities across a large geographical area and with diverse environments using machine learning. The resulting information is relevant to evaluating soil carbon, nitrogen, and phosphorus cycling. Background: Microbial-mediated soil organic matter decomposition regulates many key ecosystem functions such as soil nutrient cycling, carbon sequestration, and soil fertility. However, representing microbial processes in Earth system models is still a challenge due to the lack of...

High Protein Soybean Mutants Obtained Through Mutagenesis

JianlingL@tla.arizona.edu — Mon, 18 Sep 2023 11:40:45 GMT

This technology is a method to increase protein content in soybeans using fast neutron mutagenesis. Researchers investigated the effects on soybean seed composition and gene expression encountered in transgenically modified and mutagenized crops and found several lines that germinated well, had no apparent agronomic issues, and continually produced high protein. The approaches used in this innovation will test the range of seed phenotype variation that can be produced from transgenic or mutagenesis that will yield data to establish the comparative improvement potential in soybean production. ...

Broad Spectrum Inhibitors against Viral Methyltransferases

JianlingL@tla.arizona.edu — Fri, 15 Sep 2023 16:17:01 GMT

This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2 and flavivirus. Pilot screening demonstrated that the HTS assay was very robust and identified two candidate inhibitors. Binding studies indicated that these molecules bound directly to the essential enzymes with similar low micromolar affi...

Novel High-Strength Iron Cement is a Carbon Dioxide Sink

JianlingL@tla.arizona.edu — Wed, 13 Sep 2023 11:10:46 GMT

Background: Portland cement traditionally used with inert aggregates to form construction concrete is made in a high-temperature process that releases large amounts of carbon dioxide (CO2). With rising energy costs, high temperature processes depress profits, and release of CO2 is undesirable from an environmental perspective. It would be ideal if Portland cement could be replaced in some circumstances with an alternative material that could be made at ambient temperatures and that consumed, rather than released, CO2. This technology provides such an alternative.Applications:• When a conf...

Mobile Cancer Screening and Treatment System

JianlingL@tla.arizona.edu — Mon, 11 Sep 2023 10:31:18 GMT

This invention describes a compact mobile system for cancer screening and detection. It can be used to effectively screen and detect early cancer, and has a therapy function where it can provide treatment without the side effects that conventional methods come with (surgery, radiation and chemotherapy). This invention is particularly suitable for low-resource settings and is portable for point of care diagnosis. Background: Oral cancer is a very common cancer both in the United States and worldwide. This type of cancer is especially common in South Asian countries where it is the second ...

A Method of Treating Cardiomyopathy

JianlingL@tla.arizona.edu — Thu, 07 Sep 2023 14:47:01 GMT

This innovation is based on the finding that lack of Leiomodin-2 (Lmod2) is associated with cardiovascular issues, specifically enlarged heart or cardiomyopathy and it is better to have a truncated/mutated Lmod2 than zero or little Lmod2 present. A premature stop codon associated with Lmod2 causes truncation of Lmod2. This innovation is the use of antisense for blocking the system that recognizes and prevents the premature stop codon, thereby allowing the truncated/mutant protein synthesis. Background: Cardiomyopathy is a disease of the heart muscle that makes it harder for the he...

Leukocyte Gene Expression Predicts Human Temporal Lobe Epilepsy Seizure Frequency

JianlingL@tla.arizona.edu — Thu, 07 Sep 2023 14:27:48 GMT

The leukocyte gene biomarkers presented here identify totally new and different genes whose expression predict temporal lobe epilepsy (TLE) seizure frequency. This seizure frequency prediction is a manifestation of the underlying pathophysiology of TLE disease states which have, heretofore, not been identified to have a dichotomized genetic basis. Targeting the underlying TLE pathophysiology in a personalized, therapeutic manner, based on leukocyte gene expression, represents a new medical decision-making paradigm, amenable to pharmacologic treatment and surgical therapy. The dichotomized appr...

Low-Loss Topological Acoustic Wave Device for Telecommunication and Sensing

JianlingL@tla.arizona.edu — Thu, 07 Sep 2023 13:37:04 GMT

This innovation provides potential solutions to telecommunication and sensing devices that utilize acoustic waves as a medium. Compared to conventional elastic waves, topologically protected waves provide a significant benefit for reducing the return loss in devices. Superlattices supporting topologically protected acoustic waves provide attractive and disruptive solutions for designing the next generation of low-loss acoustic wave devices for telecommunication or sensing. Such superlattices are technologically compatible with existing acoustic wave devices. It is observed that the intr...

Human-Robotic Mimetic Haptic Control Framework

JianlingL@tla.arizona.edu — Tue, 05 Sep 2023 14:54:02 GMT

This technology is a method for training a robot to perform the tasks that typically require skilled manual labor with a trowel when installing Exterior Insulation Finishing Systems (EIFS). It measures a human’s motions while using a tool (in this case a trowel), which is then used to teach the robot to perform similarly. Background: Exterior Insulation Finishing Systems are a type of cladding that is added to the exterior of buildings to insulate and waterproof them while also maintaining a stylish appearance. EIFS installation is very labor-intensive and typically requires skilled man...

Angular Tuning of Axial Resonance in Periodic Grating Structures Design Strategy for Operating Multi-Channel CW or Mode-Locked Pulsed VECSELs

JianlingL@tla.arizona.edu — Tue, 05 Sep 2023 12:55:14 GMT

This invention can be used to develop tunable wavelength VECSEL/VCSEL/OPSL sources. This can also be used to tune absorption bands in periodic absorbers or any periodic media. This allows for engineering of tunability of a source. Furthermore, the adaptability of this invention permits the utilization of multiple wavelength ranges without needing to swap out hardware components, offering a seamless and efficient user experience. Background: Current technologies lack the range of tuning that this invention provides the user. The key innovation here is a method to tune and engineer cohere...

Photothermal Microscopy Using Whispering Gallery Microcavities

JianlingL@tla.arizona.edu — Tue, 05 Sep 2023 10:45:23 GMT

This invention uses a photothermal spectroscopy method to detect and identify individual molecules/particles without the use of fluorescent tags or radioactive ligands. Whispering gallery optical sensor technologies are on the cutting edge of biosensing technology. Photothermal microscopy has found applications in diverse fields, including materials science, nanotechnology, biology, and medicine, offering valuable insights into thermal transport phenomena, photothermal interactions, and thermal properties of complex structures. Background: Traditional methods of optical microscopy...

Hybrid SESAM Output Coupler

JianlingL@tla.arizona.edu — Tue, 05 Sep 2023 10:43:47 GMT

A novel hybrid semiconductor saturable absorber mirror (SESAM)/dielectric output coupler has been developed and employed to demonstrate a mode locked vertical-external-cavity surface-emitting lasers (VECSEL). The hybrid SESAM enables a greatly simplified optical layout for developing short pulse laser sources utilizing semiconductor based VECSELs. Background: Because the hybrid SESAM acts as both the saturable absorber needed to mode lock the laser, and optical cavity output coupler, one can make simple linear optical cavities that support high repetition rates and greater ca...

Iron Targeting to Halt Proliferation in Malignant Cells

JianlingL@tla.arizona.edu — Thu, 31 Aug 2023 10:08:43 GMT

This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron and thereby interfere in cancer cell proliferation or other iron dysregulation. The redox potential of various analogues within this class of compounds can be tuned for targeting of cancer cells. Following cellular uptake, the tetrazolium compounds of the present invention undergo reduction to produce formazan species that are capable of intracellular binding of various metals. In this approach, the initial prochelator compound forms an active metal-binding chelator under specific co...

LWIR Polarimetry for Liquid Phase Discrimination

JianlingL@tla.arizona.edu — Mon, 28 Aug 2023 15:42:56 GMT

This technology is a polarimeter in the long-wave infrared domain of the electromagnetic spectrum. These devices are able to distinguish between ice and liquid water. Therefore, this device could serve to observe natural phenomena such as glacial melt or be used in solar system exploration when identifying water, in solid or liquid form, on other celestial bodies. Additionally, such a device could be useful in autonomous vehicles to inform the vehicle about road conditions and best practices. This technology also possesses the capacity to impact the aerospace industry by providing an au...

A Hybrid Robot for Exploration and Inspection

JianlingL@tla.arizona.edu — Thu, 24 Aug 2023 16:52:30 GMT

This invention is a design of a spherical hybrid Unmanned Aerial Vehicle (UAV) and ground vehicle that minimizes energy use while traversing extreme terrain both on the ground and in the air. The robot can roll over flat and uneven terrain and, when obstacles are too big or difficult to maneuver around efficiently, the robot can transition into an unmanned aerial vehicle to get around them. Background: Exploration of unknown areas presents terrain that is unpredictable and weather and temperature conditions that can be extreme. Furthermore, energy consumption of drones and robots is a ma...

Supersonic Jet Curtains for Control of Moments on Tailless Aircraft

JianlingL@tla.arizona.edu — Thu, 24 Aug 2023 16:51:35 GMT

The invention is a method to improve the design of tailless aircraft, such as the blended wing body design. The improvement consists of using high speed jets to create a supersonic jet curtain to provide flight directional controls. The jets are installed in the wings and are able to control the pitch, yaw, and roll of a tailless aircraft. Background: A tailless aircraft is a type of aircraft that does not have any horizontal aerodynamic surface other than its main wing. This type of aircraft may still have a fuselage, a vertical tail fin, and/or a vertical rudder. The aerodynamic contr...

AFC Enabled Hybrid Tilt Propeller / Tiltwing Long Range and High-Speed VTOL Aircraft

JianlingL@tla.arizona.edu — Thu, 24 Aug 2023 16:50:50 GMT

The technology involves the design of a hybrid tilt propeller / tilt wing aircraft augmented with Active Flow Control (AFC). This proposed design enhances the aircraft's cruise efficiency and reduces high-power consumption during takeoff, without compromising on hover, vertical takeoff and landing (VTOL), and super-short takeoff and landing (SSTOL) capabilities. The control of pitch in hover using an active tail and the tilt wing augmented by AFC not only reduces the power needed for zero run takeoff or landing but it allows the elimination of the cyclic and the edge flight transition to c...

Color Corrector for MODE Optical System

JianlingL@tla.arizona.edu — Fri, 04 Aug 2023 09:39:52 GMT

This technology is a system of lenses for use in space telescopes. The optical system combines state-of-the-art optical lens technology with new corrective lenses that address shortcomings in the state-of-the-art optical systems. Background: Telescopes in space that orbit earth are typically used for scientific research and surveillance purposes. The aperture size is a limiting factor in the effectiveness of a space telescope, especially when examining deep space for exoplanets or other celestial objects and phenomena. However, the larger and more massive the telescope is,...

A Steerable, Optically Guided System for Detection of Ureteral Injury and Ureteral Catheterization

JianlingL@tla.arizona.edu — Thu, 03 Aug 2023 15:56:43 GMT

This technology is a therapeutic and diagnostic one-time-use device to place a ureteral catheter or stent without fluoroscopic guidance. Enhancements to the device may allow detection of injury to the ureter via Optical Coherence Tomography (OCT) and treatment of nephrolithiasis via laser lithotripsy. This small-diameter ureteral catheter or stent comprises an elongated body, an imaging system with a combination of lens and an electronic camera, an illumination device, a straightening rod disposed within the lumen of the elongated body, and a pushing rod. Background: The demand for urin...

Enhancing Absorption of Dietary Compounds to Promote Health

JianlingL@tla.arizona.edu — Wed, 02 Aug 2023 15:25:41 GMT

This innovation is directed to oral co-administration of glucuronidase and polyphenols for reabsorption in the gut. Glucuronidase are enzymes that can be made or derived from any source such as bacteria, recombinant, species agnostic, and others. The inactive glucuronides are cleared from the body by secretion back into the gastrointestinal track where they are not as readily reabsorbed, which the proposed invention will alleviate. This bacteria-derived deconjugating enzyme found in the body can be co-administered with health promoting compounds to enhance the bioavailability of these compound...

Novel Modalities for the Treatment of Cryptococcal Meningitis

JianlingL@tla.arizona.edu — Wed, 02 Aug 2023 09:15:54 GMT

This invention is the repurposing of oxfendazole, an FDA-approved veterinary anthelmintic benzimidazole and its novel oral bioavailability enhancing formulations for the oral treatment of cryptococcal meningitis. The oxfendazole ionic liquid containing nano formulations can lead to the development of low-cost oral treatment for cryptococcal meningitis. Background: Cryptococcal meningitis is a severe fungal infection of the central nervous system. Worldwide, nearly 220,000 new cases of cryptococcal meningitis occur each year, resulting in an estimated 181,000 deaths. Most of the illness ...

All-Fiber Single-Cavity Dual-Comb for Coherent Anti-Stokes Raman Scattering Spectroscopy based on Spectral Focusing

JianlingL@tla.arizona.edu — Tue, 01 Aug 2023 11:47:08 GMT

This technology is an an all-fiber, single-cavity, free-running, dual-comb laser system based on spectral focusing. This technique can be used in coherent anti-Stokes Raman scattering spectroscopy (CARS) and label free imaging for a variety of applications. Background: CARS is a form of spectroscopy used primarily in chemistry, physics, and related fields. It employs multiple photons to address molecular vibrations and produces a coherent signal. A benefit of CARS is that it is a label-free imaging technique that can be used in species that do not fluoresce. Applications: Coherent R...

Method and Apparatus for Snapshot 3D Imaging of Mechanical Structure at Resonance Frequency

JianlingL@tla.arizona.edu — Tue, 01 Aug 2023 11:40:53 GMT

This invention is a method and apparatus that can measure the mechanical resonance and mode shape of a mechanical structure. The apparatus can provide important information regarding the structure of an object under different loading and operating conditions. This can help designers and engineers to create a robust mechanical design, to verify the results from their frequency analysis with the final design of the structure, and to monitor change during different operating conditions. Background: Resonance is a property that is found on all mechanical structures. Resonance can be described as ...

Time to Angle Sorting Camera

JianlingL@tla.arizona.edu — Tue, 01 Aug 2023 11:26:11 GMT

This invention provides a method to sort camera-captured images based on their arrival time employing short-pulsed illumination and MEMS spatial modulator. The time-to-angle sorting method works as an add-on to commercially available cameras. Primary uses would be for driver assistance and autonomous terrestrial/aerial vehicle sensing in the detection of hidden objects under low-visibility conditions, such as fog, rain, and snow. Background: Camera-based object recognition and autonomous driving based on information, like location, type, and velocity of objects, is one of the critical f...

Quantum Computing using an Atomic-Emitter Array and a Volumetric Mode Sorter (QAMS)

JianlingL@tla.arizona.edu — Tue, 01 Aug 2023 11:21:08 GMT

This invention is a completely photonic, utility-scale quantum computer that delivers a superior level of fault tolerance over existing state of the art quantum computers. Background: Quantum computing is a promising field because quantum computers can perform complex operations efficiently and solve problems that are difficult for classical computers to solve. There are a variety of types of quantum computers with different advantages and drawbacks; one of the advantages of photonic quantum computers is that they can operate at room-temperature, while many other types of quantum comput...

TROVE: A Translational Resource for Omics-Based Validation of Expression Datasets

JianlingL@tla.arizona.edu — Mon, 24 Jul 2023 11:38:19 GMT

Translational Resource for Omics-Based Validation of Expression (TROVE) is a solution-oriented query-able disease database that integrates various -omic data from animals and humans, reflective of the One Health paradigm. The innovation is focused on dataset integration and identification, to immediately provide targeted solutions for identified infection/immunity pathogens. This technology is also able to interface with R Bioconductor package making it simple to create data visuals for the datasets. Background: Currently there are few infectious disease databases that incorporate...

Virtual Reality Neuropsychological Assessment (VRNA) System

JianlingL@tla.arizona.edu — Mon, 24 Jul 2023 11:37:58 GMT

This technology is a computerized neuropsychological assessment system to rapidly measure cognitive and behavioral abilities and impairments. This system operates by extracting multiple, simultaneous performance metrics while the patient is in a virtual reality (VR) game-like scenario. As the patient is playing this challenging VR video game, the VRNA System integrates inputs from multiple sensors with machine learning analysis. These inputs assess the various domains of real-time cognitive performance to provide a rapid, personalized assessment of neurocognitive status. Background: Thi...

The "How Much of Your Brain?" Tool

JianlingL@tla.arizona.edu — Mon, 24 Jul 2023 11:37:36 GMT

This is a psychological assessment tool that provides a simple way to track how much cognitive space a patient believes their thoughts to be taking up. This tool can be used by psychologists to easily visualize the psychological load patients spend on certain thoughts, particularly repetitive thoughts. It can be used with patients of all ages and repeated as often as needed to track progress and the potential effectiveness of psychological interventions strategies used with the patient. Background: Psychologists currently rely on their notes to best track a patient’s behavior. The...

Use of an Individual's Own Neural Network-Based Text To Speech Voice in Patients without Vocal Capacity Due to ALS and Other Conditions

JianlingL@tla.arizona.edu — Mon, 24 Jul 2023 11:19:24 GMT

This invention is a software system that helps generate a natural sounding synthetic voice from a small amount of audio files. The audio files can be from an individual’s own voice so that when their speech becomes later impaired, their same voice can still be generated. Background: Currently, there is technology available that is able to generate a natural sounding text-to-speech. However, these models require large sets of audio files and corresponding text (~24 hours). This poses an issue for ALS patients; ALS patients inevitably lose their ability to speak so it...

Production of Vulcanized Rubber using Organopolysulfide Crosslinking Agents Derived from Elemental Sulfur

JianlingL@tla.arizona.edu — Tue, 18 Jul 2023 10:37:20 GMT

Methods of vulcanization using a high content sulfur polymer, instead of elemental sulfur, have been developed for tire rubber production. The resulting high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials have improved polymer compatibility and efficient crosslinking. Furthermore, this technology suppresses "reversion," the loss of rubber stiffness over time, which is an undesirable quality. Background: Vulcanization of rubber and other polymeric materials is a well-established method for enhancing physic...

Synthesis of New Deuterated Organic Comonomers and Deuterated High Sulfur Content Polymers for Optics and Photonics

JianlingL@tla.arizona.edu — Tue, 18 Jul 2023 09:43:52 GMT

This technology is new molecular design approach to prepare high refractive index polymers with enhanced medium wavelength infrared (MWIR) and/or long wavelength infrared (LWIR) transparency that are prepared from reacting with elemental sulfur with deuterated comonomers. The polymers described herein are chalcogenide hybrid inorganic organic polymers (CHIPs) with enhanced MWIR and/or LWIR transparency and thermomechanical properties via the inverse vulcanization of elemental sulfur with new organic comonomers. To demonstrate the benefits of deuteration for IR optics, both proteo- and deu...

Methods and Apparatus for Microscopic Imaging of Eye

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 11:35:53 GMT

This technology is a low-cost microscopic imaging device that captures cellular level images for diagnosis and treatment of eye diseases. Background: The National Eye Institute estimates that over 4 million people in the US had some type of vision impairment in 2010, and this number will rise to 7 million by 2030. The most severe eye conditions require rapid diagnosis and treatment to minimize tissue damage and ongoing vision loss. This technology has the potential to improve the speed and accuracy at which eye diseases are diagnosed, and can become a standard eye imaging tool in a wide rang...

Random Multi-Spectral and Polarization Structured Light Illumination for 3D Imaging

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 11:02:40 GMT

This invention is a method to improve accuracy and acquisition time of three-dimensional (3D) imaging systems by using illumination patterns with different spectrum and polarization states and simultaneously measuring the reflected patterns that can distinguish light of different spectrum and polarization states. Unlike existing techniques that utilize sequential measurements, this invention acquires all relevant information in a single shot and can be applied to rapidly changing scenes and objects. The invention describes different random patterns for projection and an adaptive or “smar...

Method and System for Optical Transmission and Crosstalk Reduction in LIDAR using Polarized Light

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:48:44 GMT

This invention has been developed to enhance encoding methods for information transmission and to reduce crosstalk in LiDAR applications by utilizing polarized light. Instead of using binary encoding methods such as frequency resolved optical gating and on-off keying, this invention encodes vital information into the polarization state of the light pulse. This new approach decreases measurement error by generating a key code that uniquely identifies a transmitter and receiver pair. The invention also leverages the diattenuation and retardance of birefringent objects to modify the polarization ...

Method and Device for 3D Imaging and Imaging through Scattering Scenes

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:46:38 GMT

This invention describes a method to create a computational camera that can image through dynamic scattering media with high resolution. The camera can create a synthetic hologram by combining light at two closely spaced optical frequencies to produce a low-frequency synthetic wave (beat wave), largely immune to the unknown scattering processes between the hidden scene and detector. This is primarily proposed for medical imaging applications through living tissue. This noninvasive technique only uses light in the optical wave band and works with standard off-the-shelf camera technology– ...

Periodic Structures Embedded within Glass Mirror Substrates for Reflection to Non-Specular Directions

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:45:16 GMT

This technology is a method for measuring heliostats for solar energy applications, as well as any large optical surface composed of second-surface mirrors. A small diffraction grating, which is a 1D, 2D, or 3D periodic phase and/or amplitude modulation, is embedded within the glass substrate of a second-surface mirror. Light from a metrology system propagates through this grating before and after reflection, allowing it to be directed to non-specular directions to be measured by the optical system. Multiple gratings can be written in a single layer or multiple layers in the glass to provide a...

Laser Generation Apparatus and Sources Using the Same

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:38:25 GMT

This technology is an apparatus that uses a chirped pulse laser of wavelength λ1 combined with its second harmonic at λ2 to achieve a sum-frequency λ3. The chirp rate can be determined on a material basis and the process holds for λ2 = λ1/2, λ3 = λ1/3. This is achieved using nonlinear materials and the output is from a fiber source. Different material choices and λ2 chirp rates can be used relative to λ1 with repeatable input output conditions. Background: Nonlinear optical crystals are being used more and more in lase...

A Telescope for Mass Production at Low Cost

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:34:57 GMT

This technology is a new way to cost-effectively mass produce mirrors and optics for smaller (<30” aperture) telescopes. The mirrors are made using a rapid replication process and are equipped with coolers for active shape adjustment. It also employs an optical corrector near the focus to reduce atmospheric image blurring. This innovative manufacturing technique ensures high-quality, affordable telescopes for a wide range of applications. Background: The primary application of this technology is to manufacture an interferometer made of thousands of smaller telescopes that link ...

Adaptive Profile Poling of Nanophotonic Lithium Niobate Waveguides for High Overall Nonlinear Efficiency

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:32:17 GMT

Innovators at the University of Arizona have overcome the non-uniformity issue of thin-film Lithium Niobate. Adaptive profile poling is promising to realize high nonlinear efficiency with strong material second-order nonlinearity. Nonlinear efficiency can actually increase quadratically with length using this method. It was shown that the optical momentum mismatch caused by the thickness variation of thin-film Lithium Niobate wafers limits the overall nonlinear efficiency. In contrast to standard periodic poling where the domain inversion period is fixed, a near-ideal sinc function second-har...

Large Balloon Reflector for Remote Sensing

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:29:32 GMT

This technology is a suborbital antenna system that is suitable for operation from radio to millimeter wavelengths. The technology can be used for remote sensing of objects on the ground, in the atmosphere or in space. Superpressure balloons will be used to transport the technology and to maintain payloads of 2 tons to 3 tons in near space. Background: Remote sensing is a scientific method that involves using sensors to acquire information about the Earth's surface or other objects without physical contact. This is done using platforms such as airplanes, satellites and balloons to capture...

Biocompatible Ionic Liquids for Improving Delivery of Therapeutic Agents

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:17:18 GMT

This invention relates to three types of ionic liquids (ILs) that will improve the delivery of a diverse array of therapeutic agents. The first type of ILs consists of a drug as either cation or anion and a biocompatible counterion to improve the aqueous or lipid solubility and permeability of drugs and to facilitate the incorporation of these ILs into various nano formulations. The second type of ILs consists of biocompatible and pharmaceutically acceptable cations and anions are used as a solvent to solubilize and deliver drugs with poor solubility and/or permeability. The third type of ILs ...

Neural Field Algorithms for Computed Tomography Image Reconstruction

JianlingL@tla.arizona.edu — Wed, 05 Jul 2023 10:15:49 GMT

This invention is a novel deep-learning algorithm for computed tomography (CT) image reconstruction. The neural-field technique has a small graphic processing memory (GPU memory) footprint, which allows it to be applied in three-dimensional or higher-dimensional CT imaging. The proposed technique is self-supervised and trained instance-wisely, eliminating data labeling or any training of datasets. This algorithm can also produce synthesized projections that can be combined with existing projections to yield denser or complete projection data to be used by other image-reconstruction methods. B...

Entanglement Assisted Radars with Transmitter Side Optical Phase Conjugation and Classical Coherent Detection

JianlingL@tla.arizona.edu — Wed, 28 Jun 2023 10:43:19 GMT

This invention involves entanglement-assisted (EA) bistatic quantum radar applications. Employing optical phase conjugation (OPC) on the transmitter side and classical coherent detection on the receiver side shows that the detection probability of the proposed EA target detection scheme significantly outperforms both classical and coherent states-based quantum detection schemes. The system was evaluated by modeling the transmitter-target-receiver (main) channel as the lossy and noisy Bosonic channel and assuming that the distribution of entanglement over the idler channel is imperfect. ...

Optimal Receiver Design based on Linear Optics for Entanglement-Assisted Sensing and Communication

JianlingL@tla.arizona.edu — Wed, 28 Jun 2023 10:42:17 GMT

This technology is a structured receiver for entanglement-assisted communication and sensing that relies only on off-the-shelf components. This innovation may enable high-rate communication in the presence of noise and high precision quantum radar detection. Upon receiving the return of the signal, the receiver first performs a heterodyne or homodyne detection on the return. Next, phase shift and beam splitting are performed on the idlers. Finally, homodyne or photon counting is performed on the idlers. Background: Entanglement-assisted protocols entangle an initial signal with a...

Entanglement Assisted Multistatic Radars

JianlingL@tla.arizona.edu — Wed, 28 Jun 2023 10:39:35 GMT

An entanglement-assisted (EA) multistatic radar that significantly outperforms corresponding EA bistatic, coherent state-based quantum, and classical radars. The proposed radar employs multiple entangled transmitters performing transmit-side optical phase conjugation, multiple coherent detection-based receivers serving as EA detectors, and a joint detector. Background: Quantum radars offer several advantages compared to their corresponding classical counterparts: improved receiver sensitivity, better detection probability of targets in a low signal-to-noise regime, improved synthe...

Entanglement Assisted Joint Monostatic-Bistatic Radars

JianlingL@tla.arizona.edu — Fri, 23 Jun 2023 14:10:24 GMT

This technology is an entanglement-assisted (EA) joint monostatic-bistatic quantum radar scheme that significantly outperforms similar conventional radars. The system has two radars: one with both a wideband entangled source and an EA detector and another with only an EA detector. An optical phase conjugation (OPC) is applied on the transmitter side, while classical detection schemes are typically applied to both receivers. Background: Quantum radars offer several advantages compared to their corresponding classical counterparts: improved receiver sensitivity, better detection pro...

Desert Foods Cookbook

JianlingL@tla.arizona.edu — Tue, 13 Jun 2023 15:16:00 GMT

This is a cookbook containing recipes specific to local foods from desert environments. It gives an overview of foods that come from desert plants, such as wild chile, agave, and prickly pear fruit, their health benefits, environmental benefits, gardening care, and preparation methods. All recipes are plant-based and designed to take less of a toll on the environment while simultaneously boosting food security and improving health outcomes. The cookbook also contains additional resources on desert food traditions, farms to visit, and where to purchase ingredients. Background: Indu...

Cosmoceutical Gases-As-Drugs: Planet Atmosphere Gases Enwrapping into Soft Materials for Precise Medical Therapy

JianlingL@tla.arizona.edu — Wed, 07 Jun 2023 10:25:51 GMT

This invention enables the discovery of planetary gases and volatiles for medical gas therapy by using novel gas marbles delivery systems for tissue targeting or systemic and controlled deliveries. Gas and liquid “entrapping” into gel or foam materials have been formulated for various applications including drug delivery. This invention provides an alternative method for “enwrapping” gas and liquid droplets of various concentrations and from a multitude of gases and mixtures thereof originated in a planet atmosphere for a targeted and direct administration in vivo. The ...

Optical and Acoustic Coupling Materials and Technologies

JianlingL@tla.arizona.edu — Wed, 07 Jun 2023 10:22:39 GMT

This invention describes materials and chemicals with novel, optimal optical and acoustic properties that enable or improve methods that require coupling of light and sound for biomedical and defense applications related to imaging and monitoring therapy. This invention overcomes current limitations by proposing optically and acoustically transparent gel formations, such as gellan gum. In addition, the substitution for water with “heavy water” dramatically reduces the absorption of light due to normal water. These two features not only improve on existing methods that require an ef...

Heart Valve for Eccentric Orifice

JianlingL@tla.arizona.edu — Wed, 07 Jun 2023 10:21:12 GMT

This technology is a novel heart valve and deployment system that maintains eccentric geometries while optimizing valve function and hemodynamics, reducing adverse events. The asymmetrical leaflet design features two identical mirrored larger leaflets and one shorter leaflet. Traditional symmetric leaflet design features three equal leaflets that rely on diastolic closure with all leaflets meeting in the center and small bending forces needed in systole to open all leaflets. The larger leaflets preferentially open along the long axis of the ellipse and asymmetrical leaflets coopt off the cente...

Practical Synthesis of C-1 Deuterated 3‑Formylindoles by Organo-photoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid

JianlingL@tla.arizona.edu — Wed, 07 Jun 2023 10:19:12 GMT

This innovation is the synthesis of a Carbon-based indole that can be used in the creation of anti-cancer drugs. Indoles are reagents that can also be used in oncological and renal disease treatment. The new method provides a simple protocol that creates differentiated indoles that have a broad functional tolerance. This uses a more cost-effective agent and removes the need for an external light-absorbing catalyst. Specifically, these novel deuterated indoles have versatile structures and can be applied to various types of research. Background: There is a lack of cost-effective me...

DNA E2E: End-to-End Programmable Microfluidic Platform (PMP) for DNA Data “Write-to-Store-to-Read” with Cold Storage of DNA Data in Synthetic Fossils and Metal-Organic Scaffolds using Supercritical Fluid (SCF) Processing

JianlingL@tla.arizona.edu — Wed, 07 Jun 2023 10:13:19 GMT

The inventors have combined an error-correcting information strategy for DNA with a supercritical fluid method for drying and storing DNA. The system features an apparatus suitable for end-to-end programmable DNA storage automation using a write-to-store-to-read data cycle via a programmable microfluidic platform (PMP). The system also features a method for solid-state preservation of DNA data on synthetic bone or a metal-organic nanoparticle matrix using the supercritical nitrogen drying (ScND) process. With these features, the system will be able to provide a tailored error correction-based ...

Optical System for Spectral Imaging

JianlingL@tla.arizona.edu — Tue, 06 Jun 2023 11:23:26 GMT

This technology is an optical system with freeform elements that disperses and images the light from an object to a digital sensor for spectral imaging. Compared to traditional systems, which use rotationally symmetric optical systems with a separate dispersion element, the current invention is much more compact and low-cost. An optical system with freeform elements can also be designed for the object or image plane that is perpendicular to the optical axis. Furthermore, the use of freeform elements allows for greater flexibility in the design of the optical system, enabling customization for ...

Angle-Resolved Second Harmonic Generation Measurements for Cancer Diagnosis in Semi-Infinite Tissue

JianlingL@tla.arizona.edu — Tue, 06 Jun 2023 11:21:21 GMT

This innovation is a new method that uses angular differences in conjunction with an endoscope to identify cancerous or pre-cancerous colon tissue. Existing methods require a reference measurement ('normal') in every patient compared to a cancer-suspicious measurement. Instead, this method and endoscope provide for angle-resolved second harmonic generation (SHG) measurements associated with forward and backward scattered light that eliminate the need to obtain paired normal and cancer-suspicious measurements in each patient. Background: Globally, colorectal cancer was the ...

Polarization Compensation for Corner Cube Reflector

JianlingL@tla.arizona.edu — Tue, 06 Jun 2023 11:15:31 GMT

Existing corner cube reflectors introduce unwanted polarization change to incident light. This invention provides a solution to remove this polarization change and thereby reduces polarization dependent loss and improves the performance of the reflector. This solution can be applied to both mirror-based and prism-based corner cube reflectors. This invention also includes a method to design and manufacture a corner cube reflector to precisely control the change of polarization using a compensation filter and/or coating. The polarization compensation filter is made of at least one layer of patte...

Method to Reduce Polarization Aberration in Metal Mirror and Metal Mirror Device

JianlingL@tla.arizona.edu — Tue, 06 Jun 2023 11:06:45 GMT

This invention removes the diattenuation and retardance of a metal coated mirror using an additional uniaxial birefringent coating and anti-reflection coating. The method can additionally improve the angular response of any metal coated mirror by reducing the variation of the polarization aberration with angle. The invention includes coating designs, manufacturing methods, and a discussion of its applications. This technology is the first step in opening up a new path into reflective optics. The polarization of light can hold a lot of information in applications such as astronomy. This coatin...

Interface and Control of Underwater Robotics, Instruments, and Sensors from a Human Occupied Submerged Space

JianlingL@tla.arizona.edu — Tue, 06 Jun 2023 10:23:39 GMT

This technology includes hardware and software interfaces to control a robot that may be operated by a diver while underwater, or in submerged spaces or habitats, without a connection to the surface. The invention can reduce the operational complexity from tether management and may also enhance the synergistic capabilities of the robot. Background: Most subsea robotics currently on the market are frequently deployed from the surface and communicated with via hardwired tethers or wirelessly through acoustic signal transmission. In contrast to this, divers need SCUBA equipment and trainin...

Mechanism of Tissue Regeneration

JianlingL@tla.arizona.edu — Wed, 24 May 2023 12:51:32 GMT

This invention is a biodegradable patch seeded with human neonatal dermal fibroblasts and human-induced pluripotent stem cell-derived cardiomyocytes, which helps regenerate endogenous cardiomyocytes in adult murine, rat and swine models of myocardial infarction as a cause of chronic heart failure (CHF). This invention details changes in specific gene expression pathways with the recruitment of macrophages, as the mechanism of action of tissue regeneration. These pathways are not specific for cardiac muscle; thus, the researchers propose that these pathways could stimulate tissue regeneration f...

Natural Compounds including Myrosinase to Treat Alzheimer's Diseases

JianlingL@tla.arizona.edu — Wed, 17 May 2023 12:37:26 GMT

This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown beneficial effects in neuronal and microglial cell cultures. They are validated to protect neurons from cell death and unregulated microglia phagocytic activity. Background: Alzheimer’s disease (AD) is the most common form of dementia e...

Phase Unwrapping Algorithm

JianlingL@tla.arizona.edu — Mon, 08 May 2023 11:17:02 GMT

This technology is a novel method of phase unwrapping that improves the accuracy of existing fast unwrapping techniques through revising transform coordinates. Background: Phase maps have a variety of uses, from medical diagnosis including magnetic resonance imaging (MRI) to interferometric surface characterization in manufacturing and synthetic aperture radar interferometry used for geological measurement and object characterization in aerospace applications. Phase unwrapping algorithms serve the important role of supplementing whole number wavelengths to the interferometric sub-wavelength ...

Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal

JianlingL@tla.arizona.edu — Thu, 04 May 2023 14:44:29 GMT

This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive effects, reduction of side effects or adverse effects of opioid agonist therapy, and reduced withdrawal symptoms. Proof-of-concept testing in animals has shown a significant increase in oxymorphone antinociception. Backgro...

Flash Lidar with FOV Expansion

JianlingL@tla.arizona.edu — Tue, 02 May 2023 11:41:51 GMT

This technology is a method of capturing high-resolution images in laser, imaging, detection and ranging (LIDAR) with a 10x increase in field of view using Digital Micromirror Devices (DMDs) and 2D array detectors such as Multi-Pixel Photon Counters (MPPC). It utilizes the receiver field of view expansion technique, which was achieved by diffractively redirecting light to the sensor with synchronized DMDs and 2-dimensional arrayed detectors. Background: Due to the critical safety concerns surrounding the automotive industry push toward autonomous driving, new innovations are neede...

Thermal Drift Calibration of Whispering Gallery Mode Microcavities using Optical Frequency Domain Reflectometry

JianlingL@tla.arizona.edu — Tue, 02 May 2023 11:34:44 GMT

This technology utilizes optical frequency domain reflectometry (OFDR) to collect high resolution temperature measurements in biochemical applications. More specifically, accuracy of measurements is increased in the spatial domain via the OFDR technology being studied in conjunction with whispering gallery mode biochemical sensing. While temperature measurements are currently investigated with a reported temperature uncertainty of 30mK, this same technology could increase the accuracy of other parameters in biochemical sensing. Background: Biochemical sensing techniques often have...

Multiple Exposure to Increase Image Resolution and Dynamic Range using Zoom Lens and Different Aperture

JianlingL@tla.arizona.edu — Tue, 02 May 2023 11:33:00 GMT

This innovation is a method to increase image resolution by combining multiple exposures and different aperture settings to create a high dynamic range image. Images can be taken at different or same exposure times and the exact aperture setting can be determined by the user or by an initial estimate of the dynamic range of the scene. A high-resolution and high-dynamic range image can be generated by multiple exposures taken at different zoom and aperture settings. This practical technique does not require much computation overhead compared with current systems and can be done with existing ha...

Actively Focused Heliostat with Mechanically Coupled Shape Change

JianlingL@tla.arizona.edu — Tue, 02 May 2023 11:22:59 GMT

This invention is a heliostat that has its toroidal reflector continuously altered through the day. A simple mechanical coupling is used to change the reflector shape over the course of the day. Dual-axis mounts were found to maximize capability. In this way, the heliostat realizes the highest possible concentration of sunlight. This model also reduces costs by reducing mechanical complexities. Since the heliostat field in a concentrated solar power project can account for up to 50% of the capital cost, these reductions are critical to budget management. Background: Researc...

Target Axis Heliostat with Mechanically Coupled Reflector Deformation

JianlingL@tla.arizona.edu — Tue, 02 May 2023 11:22:44 GMT

This technology utilizes a mechanical coupling system that changes the shape of the reflectors on the heliostat throughout the day. In doing so, the incoming light from the sun is always focused to a sharp image. This increases the temperature at the device’s receiver and allows for higher efficiency in converting the incoming solar energy to electricity. Background: This technology builds on a previous design that included multiple components, which have since been proven unnecessary. Previous barriers to earlier versions of this technology included electronic actuators and...

Scalable Synthesis for Commercial Production of Carbohydrate-Based Molecular Scaffold Compounds for Direct Delivery of Drugs or Nutritional Supplements to the GI Tract

JianlingL@tla.arizona.edu — Tue, 18 Apr 2023 09:10:01 GMT

This invention provides a scalable synthesis method for commercial production (kilogram and greater) of novel carbohydrate-based molecular scaffold compounds for various therapeutic and diagnostic applications that have been and are being developed by UArizona inventors. Oral administration and targeted delivery of pro-drugs or other payloads, such as nutritional supplements, bonded to a carbohydrate-based molecular scaffold travel to the gastrointestinal (GI) tract, where the pro-drug is released directly in the GI tract by enzymes naturally present. This technology provides a mean...

Dynamically Deployed Communication Network Paradigm using Mesh Topology for Extreme Environments

JianlingL@tla.arizona.edu — Mon, 17 Apr 2023 16:48:09 GMT

The Dynamically Deployed Communication Network paradigm (DDCN) lays a foundation for a distributed, fully integrated multi-agent system that has operational autonomy for the exploration of treacherous surface regions (valleys, craters, lava flows, etc.), subsurface cavities (caves, lava tubes, etc.), and potentially bodies of water (lakes, oceans, etc.). One or more robotic exploration agents maintain communications with a base rover via the interconnected mesh network formed of individual communication nodes. These nodes are autonomously deployed from an exploration agent during region...

The UniDec Processing Pipeline (UPP)

JianlingL@tla.arizona.edu — Fri, 14 Apr 2023 15:48:59 GMT

This mass spectrometry analysis software and method extends the UniDec Bayesian deconvolution algorithm for application to rapid analysis of biotherapeutics, including determining the drug-to-antibody ratio for antibody-drug conjugates and calculating the correct pairing of bispecific antibodies. Background: Mass spectrometry (MS) and intact mass analysis are increasingly common in academic and industry research. This has created a demand for more robust approaches to MS analysis. UniDec is one approach. UniDec is a software package based on a Bayesian deconvolution algorith...

A Recombinant Protein to Restore the Anti-Cancer Activity of Immune Cells

JianlingL@tla.arizona.edu — Thu, 13 Apr 2023 12:14:42 GMT

This invention is a recombinant protein that is designed to restore the activity of immune cells that have been exhausted in patients with cancer. This invention focuses specifically on the restoration of the anti-cancer activity of immune cells, in particular natural killer (NK) cells. Background: Immune cell-based therapies are a widely utilized technique to fight off various illnesses. Notably, CAR-T cell therapy has been shown to be an effective treatment against cancer; however, CAR-T cell generated using exhausted T cells is not effective and continuous stimulation of CAR-T cell can lea...

Forecast Skill Evaluation Methods Specific for Convective Extreme Forecast at Sub-seasonal to Seasonal Time Scale

JianlingL@tla.arizona.edu — Wed, 12 Apr 2023 16:45:15 GMT

This software includes a method designed to evaluate forecast skill at sub-seasonal to seasonal (S2S) time scale, combining traditional evaluation methods and image processing approaches. A demonstration of this technology for the Arabian Peninsula is described in: Risanto, C.B., Chang, HI., Luong, T.M. et al. Retrospective sub-seasonal forecasts of extreme precipitation events in the Arabian Peninsula using convective-permitting modeling. Clim Dyn (2022). https://doi.org/10.1007/s00382-022-06336-8. Background: Extreme weather events such as heavy precipita...

Mesoscale Convective Sestem Tracking Method Calibrated for Arabian Peninsula Convections

JianlingL@tla.arizona.edu — Wed, 12 Apr 2023 16:35:12 GMT

This software includes a method of tracking organized atmospheric convections by developing tracking criteria through cloud top temperature and precipitation. A demonstration of this technology for the Arabian Peninsula is described in: Chang, H.-I, K. Oliver, C. L. Castro, I. Hoteit, 2021: Tracking mesoscale convective system sub-seasonal forecast in the Arabian Peninsula through satellite observation and numerical modeling products. American Meteorological Society 101st Annual Meeting, 10-15 January 2021. Background: Severe weather associated with con...

Input Selection Process for Subseasonal to Seasonal Forecast over the Arabian Peninsula

JianlingL@tla.arizona.edu — Wed, 12 Apr 2023 11:10:04 GMT

This software includes a method to evaluate and select input data for subseasonal to seasonal time scale regional climate modeling. Euopean Center of Medium-range Weather Forecasts (ECMWF) forecast ensembles are selected as forcing for the Weather Research and Forecasting model at convective permitting spatial resolution. The use of ECMWF forcing, as compared to other forcing source, significantly improved forecast capabilities of convective weather extremes at extended forecast lead times. A demonstration of this technology for the Arabian Peninsula is described in: Risanto, C.B., ...

Robotically Applied, 3D-Sprayable Exterior Insulation and Finish Systems (EIFS) for Building Envelope Retrofits

JianlingL@tla.arizona.edu — Tue, 11 Apr 2023 12:59:25 GMT

This invention is an autonomous, robotically applied, 3D-sprayable exterior insulation and finish system for building envelope retrofits. The invention will be able to automatically sense and adjust to any given envelope shape to monitor and control the layer thickness of the exterior insulation. The sensing technology inside the robot will enable real-time alterations during the application of the insulation and finish. Background: In the United States, there are approximately 126 million existing buildings that consume around 74% of the electricity produced in the country and contribu...

Method and System for Passive and Active Agent Delivery for Biomarker and Treatment Means

JianlingL@tla.arizona.edu — Thu, 06 Apr 2023 09:18:13 GMT

Plant-based extracellular vesicles have features leading to low immunogenicity with innate bioactive agents for targeting and/or treating specific biological effects. They can also be used as carriers with cargo drug from natural or synthetic products with higher bioavailability. The variety of plant categories also provide broad resources for lower cost production. Culture conditions may also be cost effective and so these vesicles are promising new drug delivery systems or could also be carrying biomarkers for targeted deliveries. Use in diagnostics, therapies, CBRN medical countermeasures b...

A Bifacial PV Module Hybridized with III-V PV Cells

JianlingL@tla.arizona.edu — Wed, 05 Apr 2023 14:17:32 GMT

This invention is a new type of hybrid PV module that overcomes previous deficiencies of light loss and prohibitively high manufacturing cost. It takes a complete manufactured bifacial PV module as its starting point, which has single-junction PV cells sealed between thin glass windows. This module serves not only to harvest the energy of diffuse light, but also to carry and cool an array of small multijunction, III-V PV cells to harvest direct sunlight with very high conversion efficiency. The small cells are mounted to the module’s front window on small copper/ceramic substrates. An ar...

Allosteric Inhibitors of the Main Protease of SARS-CoV-2

JianlingL@tla.arizona.edu — Wed, 05 Apr 2023 10:45:46 GMT

In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that of known covalent inhibitor boceprevir. In a cell-based antiviral assay, these inhibitors can inhibit the virus growth with EC50 in the range of 2-3 μM. The mechanism of action of JMX0286, JMX0301, and JMX0941 were characterized by enzyme kine...

High Refractive Index Photoresin for Nano 3D Printing

JianlingL@tla.arizona.edu — Tue, 04 Apr 2023 14:13:09 GMT

This technology is a new resin for use in two-photon lithography, which offers a refractive index higher than existing commercial resins. As a result, it greatly expands the capabilities of 3D printing at a nano scale. Background: Technologies such as two-photon lithography are 3D printing, or additive manufacturing, techniques that use lasers to change the chemical composition of a resin material into a harder material. Most 3D printing requires printing the structure one layer at a time, building it up layer-by-layer. Two-photon lithography, on the other hand, uses a laser to focus li...

Calcimycin as Antifungals

JianlingL@tla.arizona.edu — Mon, 27 Mar 2023 09:57:33 GMT

A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods do not prevent intein splicing, based on a study done on mice, CMN has been shown to be effective at reducing the fungal load of cryptococcosis and may also be extended for use against other intein splicing pathogens. Background: Cryptococco...

Versatile Space Telescope for Quantum Key Distribution

JianlingL@tla.arizona.edu — Thu, 16 Mar 2023 11:16:34 GMT

The Versatile CubeSat Telescope (VCT) is a CubeSat-enabled telescope design with an increased aperture and decreased divergence over state-of-the-art systems. It also provides thermal stability, which enhances the signal-to-noise ratio, reduces the error rate, and improves performance. Finally, it can preserve the polarization of received signals to enable applications like free-space quantum key distribution (QKD). The purpose of the VCT is to provide a low-cost, high-performance, and mass-producible space telescope that uses diamond-turned rather than polished optics and a fine-pointi...

Glycopeptide-Lipid Supramolecular Assembly

JianlingL@tla.arizona.edu — Wed, 15 Mar 2023 15:33:14 GMT

This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin, VEGF peptide fragment, oxytocin, VIP agonist, or PACAP agonist. This technology may enable formulations for a wide variety of therapeutics in pain, neuro, and other regulatory systems. Background: A current pharmaceutical challeng...

Wireless, Wearable NFC Enabled Power and Communication for Chronic Interfacing with Battery-Free Implants

JianlingL@tla.arizona.edu — Fri, 03 Mar 2023 07:42:14 GMT

This device will allow for long-term, secure, and reliable data collection from implantable biosensors in a simplified manner. An intended patient simply dons this device, and it will collect and transmit data indefinitely with no further interaction. This technology introduces a wireless, wearable, near-field communications (NFC)-capable device which can energize and control fully implantable, battery-free electronics. This device is embedded in a low cost, custom fitted, 3D-printed wearable mesh to ensure 24/7 communication with a target implant over periods of weeks to months. Onboard Bluet...

Rapid, Sensitive Detection of PFOA with Smartphone-Based Flow Rate Analysis utilizing Competitive Molecular Interactions during Capillary Action

JianlingL@tla.arizona.edu — Thu, 02 Mar 2023 12:50:01 GMT

This invention pertains to a system of detecting perfluorinated-carbon alkyl chains (PFAs) with a smartphone by analyzing the flow rate. By using a paper-based microfluidic chip, this invention provides rapid detection of Perfluorooctanoic acid PFOAs in a lab. The procedure uses commonly available reagents to flow through a microfluidic chip while also loading it with the testing sample. Within 30 minutes of loading the sample, the scientist is able to gather their data. The readout time can be as low as five minutes. Background: Per- and polyfluoroalkyl substances (PFAS...

Nanoparticles for UV-Free Activation of Photochemical Reactions

JianlingL@tla.arizona.edu — Thu, 02 Mar 2023 07:25:06 GMT

This technology involves the implementation of materials and methods that allows activation of photochemical reactions using safe, near-infrared radiation. This "silent" near infrared (NIR) to UV upconversion can be incorporated in many promising technologies currently deemed unsafe or incompatible with biomedical use by eliminating residual damaging UV radiation. Background: Nanoparticles and photochemistry are a growing area of biomedical research with broad applications, including drug delivery, bioadhesives, polymerization, and photodynamic therapy. T...

Reversible Crosslinking to Preserve Cell-Specific Gene Expression Across Biospheres

JianlingL@tla.arizona.edu — Mon, 27 Feb 2023 13:24:06 GMT

This invention includes chemical methods and reagents to reversibly immobilize the cellular state of gene expression in the field followed by the release of the immobilization in the laboratory for analysis of the gene expression state. Support for this invention was provided by CALS via the Hatch allocation. Background: Characterization of single-cell gene expression from plants is a crucial technology for the improvement of agricultural crops. Current laboratory methods are incompatible with field studies because the time between sampling plants and laboratory analysis changes t...

Virus Inducible Switch

JianlingL@tla.arizona.edu — Mon, 27 Feb 2023 13:22:01 GMT

This invention describes a novel platform to control expression of specific plant genes with viruses. Background: When many plants are challenged with a viral infection, one of the primary defense mechanisms they have evolved is to deploy the use of plant RNA silencing pathways to control gene expression. Likewise, viruses have co-evolved to evade this mechanism with viral suppressors of RNA silencing. In this technology, the inventors propose the use of a novel system that uses these defense mechanisms in plants to create a modular switch that can be attached to any gene of interest ...

Targeted Cancerous Cell Specific Suicide Gene Therapy

JianlingL@tla.arizona.edu — Mon, 27 Feb 2023 13:18:07 GMT

This invention describes a novel cancer therapy method that induces cell death mechanisms in only cancer cells. Background: The current standard of care for cancer therapy in many cases is chemotherapy. Chemotherapy, like many cancer treatments, causes significant amounts of healthy cells to die in addition to the cancer cells, leading to the well-known toxic side-effects. Additionally, treatments like cytotoxic gene therapy cause cells to express cytotoxic proteins, leading to cell death. This is a very effective tool but has not yet been refined to only allow cancer cells to be impacted. Th...

Breast Density Assessment Device

JianlingL@tla.arizona.edu — Mon, 27 Feb 2023 13:13:58 GMT

This invention is a non-invasive, inexpensive, comfortable and portable diagnostic test to screen for breast cancer. Designed for early detection particularly among minority populations and as a preliminary screening tool before mammography or MRI assessment. Bioelectrical impedance analysis is a simple, quick, and non-invasive technique for measuring breast density and composition. Using bioelectrical impedance analysis as a diagnostic tool for breast cancer screening through examination of the electrical characteristics of breast tissue provides information on a continuous basis to pat...

An Efficient And Improved Chemical Conversion Of The Natural Product Physachenolide D (LG-01) To Its Analogue LG-134 With Potent Anticancer Activity

JianlingL@tla.arizona.edu — Mon, 27 Feb 2023 10:01:50 GMT

Invention: An improved process of chemical conversion of the natural plant product physachenolide D (PCD) to a C-18 analogue (LG-134) of physachenolide C (PCC). Background: The standard yield of LG-134 using current methods is relatively low at 1/3 resultant from original products. This method allows for the yield to be double current chemical processes. LG-134 is especially important due to its potent anticancer activity against prostate cancer and melanoma Applications: • Chemical yield of LG-134 Advantages: • ...

Trapped particle classification in additive manufacturing

JianlingL@tla.arizona.edu — Thu, 23 Feb 2023 10:23:50 GMT

This technology is an improvement to a rapid design approach for designing nanophotonic devices. It is a method of optical positioning and linking (OPAL) using highly focused lasers (sometimes called “optical tweezers”) used for nanofabrication of molecules for devices, drugs, and other nano-metamaterials. Combined with the previous optical positioning and linking invention, it could enable the creation of significantly larger and more complex nanophotonic devices, consisting of many thousands of microscale or nanoscale building blocks. It can also be used as a method of aut...

Bioinspired Glycolipids as Fugitive Dust Suppression Agents

JianlingL@tla.arizona.edu — Mon, 13 Feb 2023 09:43:50 GMT

This technology involves the utilization of bioinspired glycolipids to reduce fugitive dust emissions. Background: Fugitive dust is defined by the EPA as dust that "arises from the mechanical disturbance of granular material exposed to air" and common sources of such materials include constructions sites, dirt roads, barren fields, mining operations, smokestacks, etc. Many governments are taking immense efforts to prevent and control air pollution by introducing numerous stringent regulations and standards for the environment and safety of workers, resulting in increased demand for ...

Plasma from Mouse Stroke Model that can be used to detect Neurofilament Light Chain

JianlingL@tla.arizona.edu — Tue, 07 Feb 2023 15:07:55 GMT

This invention relates to the intellectual property that consists of a stored archive of hundreds of mouse blood plasma samples that were taken from a laboratory stroke model for mice under various conditions of the mice age and the time past stroke. By evaluating the quantity of neurofilament light (NfL) chain (protein) within the samples they can serve as an indication of neurological damage. These indicators can then be used to develop correlations and calibrations to other measurements or assay methods of neurological damage post-stroke. Background: Neurofilament Light chain (NfL) i...

Graded Index Waveguide and Coating for Display Applications

JianlingL@tla.arizona.edu — Tue, 07 Feb 2023 10:37:00 GMT

This innovation improves image quality and reduces polarization aberration in waveguide display systems by using a graded-index waveguide and/or coating. Specifically, the innovation improves the performance of the display by increasing the bandwidth, field of view and reducing polarization-dependent loss. Using a graded-index coating in waveguide applications allowed for complete correction of polarization phase shift from total internal reflection. The critical angle between the waveguide core and cladding remains the same, as demonstrated by multiple fundamental principles. Backgrou...

Decision Support Logic for Long QT

JianlingL@tla.arizona.edu — Wed, 01 Feb 2023 10:16:22 GMT

This technology is a clinical decision support system that can help to increase the awareness of the appropriate physician. This innovation can swiftly evaluate whether a patient’s heart rate is beating at an arrhythmic interval. This new clinical decision support system will be able to diminish the risk of sudden death due to inpatient cardiac arrests. Doctors may prescribe drugs to patients for the treatment of Torsades de Pointes, which can be diagnosed based on an arrhythmia in the QT interval on the ECG readout. Many medications can increase the risk of such an arrhythmia by ...

Diagnostic for Non-Invasive Screening and Early Detection of Adenomyosis

JianlingL@tla.arizona.edu — Wed, 01 Feb 2023 09:30:01 GMT

This technology is a non-invasive diagnostic for the screening and detection of adenomyosis. This could be used for women who are suffering with symptoms of chronic pelvic pain and adenomyosis for diagnosis without an invasive hysterectomy. In preliminary studies, there have been high acceptance of a particular sampling, that can provide information reflecting uterine conditions due to anatomical continuity across the female reproductive tract. Thus, non-invasive sampling may allow detection of adenomyosis-related metabolites and proteins in the cervicovaginal microenvironment, which would add...

Method for Optimizing Test Selection based on Cost and Uncertainty

JianlingL@tla.arizona.edu — Thu, 26 Jan 2023 14:08:15 GMT

This technology is an algorithm/method that optimizes the potential knowledge gained about a complex system when performing robustness testing with a set of constraints (cost, resources, etc.,). It can be used to optimize which test should be run based on the constraints and is particularly useful for prioritizing tests based on both the cost of each test and the uncertainty associated with the knowledge of the system being tested. Background: Optimization algorithms have diverse applications in many industries, but this algorithm is primarily for use in defense and biopharmaceuti...

Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres

JianlingL@tla.arizona.edu — Tue, 24 Jan 2023 15:21:17 GMT

This technology is designed to relate to myosin binding protein-C (MyBP-C), more particularly to methods and compositions for modifying MyBP-C in sarcomeres, e.g., protein engineering for studying MyBP-C in sarcomeres. It is an objective of the present invention to provide methods and compositions that allow for a single gene-edited mouse model that allows for rapid exchange of new combinations of modified or mutant MyBP-C. Background: According to the CDC, one person dies every 36 seconds in the United States from cardiovascular disease. Heart disease is also the leading cause of...

Using the Serum Phosphoproteome of Migraine Patients as a Theragnostic

JianlingL@tla.arizona.edu — Tue, 24 Jan 2023 15:20:26 GMT

Biomarkers for neurological disease are lacking. Preliminary data, using an in vitro model of the blood brain barrier has suggested that serum release of tight junction proteins and the associated phosphoproteome may have utility as a biomarker for headache presence (diagnostic), such as migraine, and in therapeutic effect (theragnostic). This invention is directed to a theragnostic for identifying disease state and prediction of tissue degradation so that secondary ailments can be ameliorated. Background: Migraine is the most common primary headache disorder and the second most disabling hum...

Infected Tissue Removal Tool

JianlingL@tla.arizona.edu — Tue, 24 Jan 2023 14:11:52 GMT

This invention is a simple and reusable handheld device for the surgical removal of infected tissue that uses simultaneous curettage (scraping), aspiration (suctioning), and irrigation (cleaning). The tool is unique among prior art for its use of curettage instead of reaming (drilling). This tool can improve the process of removing tissue from a necrotizing infection while leaving adjacent healthy tissue intact. The project was funded by the University of Arizona’s Department of Biomedical Engineering. Background: Demand for orthopedic technology designed for surgical treat...

Dithiophosphoric Acid Monomers for Polymer Synthesis and Functionalization

JianlingL@tla.arizona.edu — Tue, 24 Jan 2023 13:49:49 GMT

This technology is a new polymer chemistry composed of –SH-P=S-function groups which can be made from elemental sulfur, white phosphorus, and cheap alcohols, providing a route for non-petroleum-based polymers from widely available raw materials. Functionalized polymers of a reaction product of a polymer including one or more olefins and a dithiophosphoric acid compound can provide a wide range of olefinic polymers in bulk-neat conditions or in solution via eletrophilic addition processes. Such new compositions provide a wide range of new functional polymers via an inexpensive polymer pro...

Synthesis of New Polysulfide Materials derived from Sulfur Monochloride with for Optical Material Applications

JianlingL@tla.arizona.edu — Tue, 24 Jan 2023 13:29:31 GMT

This invention describes a range of low-cost polymer compositions and method of making for high index, high Abbe number consumer optics. This process improves upon the synthesis of thermoplastic and thermoset polymers, achieving both high molecular weight in linear thermoplastics and highly crosslinked thermosets. It was also found that these materials possess a favorable synergy of low-cost monomers like sulfur monochlorides and allylic monomers. Background: The consumer eyewear global market estimated at greater than $100 billion. Current optical polymer technology revolves around wel...

Functionalization of Soluble Guayule Resins using Functional Dithiophosphoric Acids

JianlingL@tla.arizona.edu — Tue, 24 Jan 2023 13:25:25 GMT

Functionalized polymers of a reaction product of a polymer including one or more olefins and a dithiophosphoric acid compound can provide a wide range of olefinic polymers in bulk-neat conditions or in solution via eletrophilic addition processes. Such new compositions provide a wide range of new functional polymers via an inexpensive polymer production process and as a route to low cost, specialty optical and flame retardant polymers. Suitable olefins include polybutadienes, polyisoprenes, natural soluble or gum rubber, guayule resins, polydienes, and cyclic olefins. Background: ...

A Gamma-ray Photon Counting Detector Based on Side-readout of Monolithic Scintillator Layers

JianlingL@tla.arizona.edu — Wed, 18 Jan 2023 12:17:27 GMT

Researchers at the University of Arizona have developed a gamma-ray photon counting device that works similarly to PET, but with a novel architecture that improves the accuracy and speed in determining the location of the biological targets, and is less costly to manufacture. Background: Positron Emission Tomography (PET) is a common and reliable medical imaging technology, able to monitor metabolism or the presence of certain biological molecules in body tissues. The sensitivity is several orders of magnitude higher than MRI, CT, or SPECT; however, there remain...

Quantum Message-Passing Receivers for Quantum-Optimal Laser Communications

JianlingL@tla.arizona.edu — Thu, 12 Jan 2023 13:30:44 GMT

This technology is the first fully structured design of an optical joint-detection receiver that can attain the quantum limit of laser communication. The proposed receiver circuit provides an alternative proposal for a quantum supremacy experiment, targeted at a specific application that can potentially be implemented on a small, special-purpose, photonic quantum computer capable of performing cat-basis universal qubit logic. Background: This invention opens the possibility of reaping a quantum enhancement in lasercom data rates in photon-starved communication scenarios such as deep space las...

Functionalization of Soluble Polydienes and Polyisoprenes using Dithiophosphoric Acids

JianlingL@tla.arizona.edu — Wed, 11 Jan 2023 15:41:03 GMT

Researchers at the University of Arizona have found that functionalized polymers of a reaction product of a polymer including one or more olefins and a dithiophosphoric acid compound can provide a wide range of olefinic polymers in bulk-neat conditions or in solution via eletrophilic addition processes. Suitable olefins include polybutadienes, polyisoprenes, natural soluble or gum rubber, polydienes, and cyclic olefins. These novel and remarkable findings are anticipated to have broad technological impact as both a new inexpensive chemical process for polymer synthesis for the petrochemical an...

Neonatal Anorectal Tonometer with Disposable/Detachable Tip

JianlingL@tla.arizona.edu — Wed, 04 Jan 2023 16:08:55 GMT

This technology is a neonatal anorectal tonometer that involves a detachable, fluid-filled tip with a quick release system involving (magnet & plate) that connects the tip to a force sensor inside the handle of the device. This device can be used as a substitute for digital rectal exams. Background: Cauda Equina Syndrome (CES) occurs when the Cauda Equina nerve fibers become irritated by pressure or inflammation. The treatment for Cauda Equina is immediate surgical intervention. The absence or reduction of rectal tone is used in the diagnosis of several neurological conditions including C...

DYRK/CLK PROTACS

JianlingL@tla.arizona.edu — Wed, 04 Jan 2023 09:16:02 GMT

This invention describes a set of novel molecules that target and degrade DYRK/CLK for several potential therapeutic purposes. Background: Proteolysis-targeting chimeric molecules (PROTACs) are small molecules used to decrease a gene’s protein expression by targeting the protein for ubiquitination and degradation after it is created. This mechanism has applications in a range of therapeutics. One class of targets with therapeutic potential is the DYRK/CLK class of proteins. DYRK/CLK is associated with severity of COVID-19 infections, glioblastoma, and cognitive impairment such as Alzhei...

Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals

JianlingL@tla.arizona.edu — Wed, 21 Dec 2022 08:03:12 GMT

This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent main protease inhibitors with high enzymatic inhibition and antiviral activity against SARS-CoV-2. Background: The COVID-19 pandemic caused by the SARS-CoV-2 virus has brought forth an urgent need for novel drugs and therapeutics to help fight the novel disease. Demand for ...

KM Cells - A Metastatic Cell Line and Method of Producing

JianlingL@tla.arizona.edu — Tue, 06 Dec 2022 09:26:59 GMT

In this study, researchers at the University of Arizona investigated an early cancer invasion event using a unique in vivo model. Muscle invasion was tested by the ability of prostate cancer cells to colonize the inferior surface of the respiratory diaphragm of male NGS mice, invade into and through to the superior surface. They isolated and compared the biological, cellular, and molecular characteristics of “Inferior” non-invasive tumor. “Muscle-resident” cells that invaded and now reside within the diaphragm muscle of “Superior” cells that have completely ...

Human Colon Polyp Derived Organoid

JianlingL@tla.arizona.edu — Mon, 21 Nov 2022 09:47:42 GMT

This innovation is a patient-derived organoid that is used as a screening platform to study both tissues patterning and the kinase pathway dynamics in single cells across many conditions. Through this technology one is able to evaluate the patterning and homeostasis of the cells and tell when they are out of alignment. Through the use of this technology the architecture of the human colon can also be studied and evaluated. Background: Since the colon is responsible for waste removal in the body and the body’s overall health, being able to evaluate the architecture of the colon could be ...

Plant-Based Electrical Source

JianlingL@tla.arizona.edu — Wed, 09 Nov 2022 09:51:38 GMT

This invention is a plant-based rechargeable battery with all components produced naturally making its operations suitable for flexible, wearable, or implantable applications. It could provide novel electrical-power source directly integrated with wound healing materials for locally stimulating biological reactions with therapeutic effects. These may also be combined with embedded electronic circuitry to actuate, monitor, or control wearable or implanted medical devices. As these materials can be biodegradable, they could also be reducing interventions for the removal of defective or old devic...

Method for Diagnosing to Enable Treatment of Overwhelmed Myelin Lipid Processing in the Brain After Stroke

JianlingL@tla.arizona.edu — Fri, 04 Nov 2022 13:32:45 GMT

This invention addresses and provides a solution to secondary neurodegeneration post-stroke. It was discovered that foam cells form within primary infarcts and areas of secondary neurodegeneration after stroke. This invention provides for a method of noninvasive imaging and assessment of fatty acid oxidation in the brain after stroke using radionuclide and magnetic resonance-based imaging currently used to measure myocardial fatty acid oxidation in cardiometabolic disease. This is intended as a means of diagnosing, treating, and monitoring inflammation and preventing secondary neurodegene...

Treating or Preventing Anorexia Nervosa via Precision Targeting of Neuronal Circuit

JianlingL@tla.arizona.edu — Fri, 04 Nov 2022 09:34:37 GMT

This invention provides methods of treating one or more eating disorders, including anorexia nervosa, bulimia, and related clinical syndromes. A new treatment strategy has been discovered, which inhibits two different neural circuits, which rescues all three of the activity-based anorexia (ABA) animal model phenotypes of extreme increases in wheel activity, decreases in food intake, and consequently, life-threatening loss in body weight. Methods of administration for a therapeutic may include electric brain stimulation and/or pharmacological inhibitors of specific protein expression. Ba...

Peptide Therapeutic for Immune Response Activation against Metastatic Triple Negative Breast Cancer

JianlingL@tla.arizona.edu — Thu, 03 Nov 2022 15:00:00 GMT

This invention provides compositions and methods for treating triple negative breast cancer using peptides or peptide mimics that bind to epidermal growth factor receptor (EGFR) to block EGFR nuclear translocation. This mode of action alters EGFR-dependent gene transcription, induces the loss of cancer cell survival and migratory capacity, and induces tumor regression. This therapeutic induces cell death in wildtype EGFR-expressing cancer cells, but not normal epithelium. Efficacy experiments in a mouse model for EGFR-dependent breast cancer resulted in significant tumor regre...

Smart Programmable Ultraviolet Germicidal Irradiation System

JianlingL@tla.arizona.edu — Mon, 31 Oct 2022 11:20:28 GMT

This invention is a sanitizer that utilizes UV radiation to sanitize closed rooms. The invention will be able to be programmed and automated to precisely deliver the exact does of UV radiation around the area of interest while also considering safety. The sanitizer will irradiate UV light with multiple beam steering devices to selectively sterilize the different areas in a room. Background: The appearance of SARS-CoV-2 in 2019, created a pandemic that resulted in 775,431,269 infections, and a total of 7,047,741 deaths worldwide as of May 2024. The pandemic also led to a large dema...

Polarization Aberration Compensator

JianlingL@tla.arizona.edu — Mon, 31 Oct 2022 11:19:45 GMT

This innovation is a method of design and fabrication process for polarization aberration compensator, which can be used in existing optical systems to reduce the overall polarization aberration. This method can be used in existing optical systems to greatly reduce the overall polarization aberration in high-performance optical systems such as in microscopy, metrology, lithography, high-resolution imaging, and especially augmented reality or virtual reality (AR/VR) applications. While optical system can be designed to reduce polarization aberration, there is none known that can reduce the pola...

The BORING (BurrOwing & Regenerative IN-Ground) Vertical Farm for the Moon, Mars and Beyond

JianlingL@tla.arizona.edu — Mon, 31 Oct 2022 10:22:42 GMT

This technology is a vertical farm designed specifically for the controlled- environment crop and food production function of a bioregenerative space life support system. It would enable long-duration crewed missions on the Moon, Mars and beyond while mitigating the impacts of extreme extraterrestrial environments. Background: Vertical farming is used on Earth to ease supply chains by providing local produce, vastly increasing the capability of farm space and for research into future farming techniques. This technology is the target of many scientists and companies that want to explore ...

Shrimp Viral Promoters for Gene Expression and Uses Thereof

JianlingL@tla.arizona.edu — Mon, 31 Oct 2022 10:13:43 GMT

This is a novel promoter for gene expression that can be used across species. By understanding the genetic makeup of animals and insects, we can learn how to improve human life. Viruses that affect crustaceans may be able to provide insight into genetic promoters that can interact with prokaryotic and eukaryotic cells. There are different types of genetic expression. A gene can be expressed within the same species (i.e. homologous expression) or in a different species than the one in which it originates (i.e. heterologous). Baculovirus penaei (BP) has an affinity to bind with many diffe...

Solar Hot Air Balloon Vent

JianlingL@tla.arizona.edu — Thu, 06 Oct 2022 11:56:27 GMT

This technology is a solar hot air balloon vent that allows for the release of heated air at the command of a computer or remote control. By controlling the release of heated air from within the balloon, the altitude of the balloon could be adjusted at will. This control of altitude then offers the possibility of directional control as winds tend to blow in different directions at different altitudes. This could be utilized to have the balloon blow with the wind, using no propulsion, to any destination of choice. The possibility of station keeping above a certain point on the ground or executi...

Spectrum and Polarization Programmable Light Source

JianlingL@tla.arizona.edu — Thu, 06 Oct 2022 11:23:50 GMT

This technology is a programmable light source that can synthesize an arbitrary spectrum and polarization state. The instrument can be utilized as a tunable light source, spectrum equalizer, polarization compensator, wavelength scanner, and polarization state generator, in applications where control of the output polarization state of the light is required. Applications include telecommunication, 3D imaging, biomedical imaging, microscopy, remote sensing, ellipsometry, polarimetry and spectroscopy. Background: A Tunable Light Source or TLS is used to maximize throughput in the visible region ...

Micro-Torsion Balance

JianlingL@tla.arizona.edu — Thu, 06 Oct 2022 11:19:08 GMT

This technology is a new ultra-sensitive torsion balance device small enough to fit on a microchip which can be used to measure forces, gravity or acceleration with a high degree of resolution. Background: A torsion balance measures torque by monitoring the rotation of a test mass suspended from an elastic fiber acting as a torsion spring. To increase the sensitivity of the balance, the size of the fiber can be reduced, resulting in a smaller torsional stiffness and, therefore, larger rotation. This technology merges the concepts behind the original torsion balance with modern- day technolog...

3D Printed Lightguide Array for Optical Imaging

JianlingL@tla.arizona.edu — Thu, 06 Oct 2022 11:12:45 GMT

This technology is a collection of transparent glass or polymer elements (a lightguide array) for routing light to an array of sensors for use in spectral imaging. Background: Spectral imaging combines traditional optical images with spectroscopy to capture the spectral properties at each part of an image. This technology is useful because it can provide visibility into things not typically recognizable through observing the normal visible light spectrum like the naked eye does. There are many applications for spectral imaging, and the list of applications is rapidly expanding. In order to ...

Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification

JianlingL@tla.arizona.edu — Thu, 06 Oct 2022 10:18:25 GMT

Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is designed with a cell-type-and circuit-specific complement tagging system using viral vectors in conjunction with transient activation protocols of glial cells in target areas using AAV vectors. The synapse removal tools are demonstrated at various...

Mini-Sensor Suspension System for Supine CO2 Monitoring

JianlingL@tla.arizona.edu — Wed, 07 Sep 2022 11:18:52 GMT

University of Arizona researchers have developed a non-invasive device that measures carbon dioxide (CO2) concentration around a person’s face, which has important implications for patients in hospitals and treatment centers. By collecting and analyzing the respiratory gases around a supine subject’s face, the system can provide insights into human physical conditions such as sleep stage and sleep quality. The mini-CO2 sensor samples concentrations in a range of 0 to 50,000 ppm with 1 reading per second and ± 70 ppm accuracy. A three-dimensional CO2 bubble i...

Organoid Models of Pituitary Adenomas

JianlingL@tla.arizona.edu — Wed, 07 Sep 2022 11:14:24 GMT

This technology is a patient-derived organoid of a pituitary adenoma for the purpose of identifying treatment for Cushing’s Disease (CD). The lack of specificity of current standard of care treatments with low efficacy and tolerability makes CD a medical therapeutic challenge. One major limitation to developing new medical therapies is the lack of human relevant model systems. Here, the inventors harvested human pituitary adenoma tissue during transsphenoidal surgery from patients to generate organoids (hPITOs). They utilized several methods to investigate the organoid model, inclu...

Non-Imaging, Random-Sampling Second Harmonic Generation Measurements to Distinguish Colon Cancer

JianlingL@tla.arizona.edu — Wed, 07 Sep 2022 11:11:59 GMT

Second-harmonic generation (SHG) microscopy has become a powerful modality for imaging a diverse range of tissues. A preliminary study demonstrated that non-imaging, randomly sampled SHG intensity measurements are likely sufficient to distinguish normal colorectal tissue from tumor/tumor-adjacent tissue with digital simulation of random sampling. While SHG images have been used endoscopically for tumor diagnosis before, the process of taking an SHG image complicates the endoscope and sets lower limits on the size, due to the necessity of scanning mechanisms. The novelty of the proposed non-ima...

Diagnostic for Screening and/or Predicting Women "at risk" for the Development and Progression Endometrial Cancer

JianlingL@tla.arizona.edu — Wed, 07 Sep 2022 11:06:51 GMT

This invention describes a novel method to use metabolic markers in samples obtained from cervicovaginal lavage (CVL) and machine-learning algorithms to detect patients “at risk” for endometrial cancer (EMC). Background: Endometrial cancer (EMC) is the most common gynecological cancer. The American Cancer Society estimates that in 2021 about 66,570 new cases will be diagnosed, with an estimated 12,940 deaths. Diagnosis typically requires invasive sample collection for biopsies and can only be carried out after the disease has progressed significantly. In this technology, the inve...

Small Molecule Chaperones of CLN1 and CLN2

JianlingL@tla.arizona.edu — Tue, 06 Sep 2022 10:12:28 GMT

The inventors here have identified a method of treating Batten Disease with small molecules that target palmitoyl-protein thioesterase 1 (PPT1), tripeptidyl peptidase 1 (TPP1), enzymes that are deficient and less active in Batten disease or Neuronal Ceroid Lipofuscinosis. The CLN1 and CLN2 genes regulate the production of these enzymes, respectively. Background: Batten Disease, or Neural Ceroid Lipofuscinosis (NCL), is a family of rare diseases caused by the autosomal recessive genetic mutations. Batten Disease is an inherited genetic disorder that affects the function of lysosomes ...

Design and Application of Novel Ligand-Induced Split-Protein Systems

JianlingL@tla.arizona.edu — Thu, 01 Sep 2022 09:47:26 GMT

This invention is a split protein system that functions as a biotechnological chemically-induced dimerization (CID) tool. These CID systems are useful for biological research to control numerous outputs in living organisms such as inducing the activation of a specific protein, protein localization, and inducing transcription. This novel CID system can be used to stabilize a newly designed ternary complex. Background: CID is a biotechnological method where two or more proteins can bind with one another and form a ternary or higher complex only in the presence of a specific small molecule or ot...

Novel Multi-Omics Aging Clock

JianlingL@tla.arizona.edu — Thu, 01 Sep 2022 09:15:22 GMT

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes in this metric following short-term treatment with an anti-aging intervention. This timing reflects the likely point in life where a mammal might expect to receive such an intervention in the clinic. These drugs can then be prioritized for det...

Methods and Materials for Modulating Construct Wear Due to Cyclic Loading

JianlingL@tla.arizona.edu — Wed, 31 Aug 2022 10:20:43 GMT

Rethinking the structural organization of a polymer is a normally forgone solution for improving polymer flexibility. Here, the inventors have created four improved ways to manufacture polymers. The first is to create it at its mid-stress point, the second is to make the polymer with a shifting neutral axis, the third method uses polymers to provide support at high-stress points along with the polymer, and the fourth is to use fibers as the support system. All these methods increase the amount of stress that a device can undergo, and it can be used for a longer time. Background: Method a...

Polymeric Heart Valve System and Method of Manufacture

JianlingL@tla.arizona.edu — Wed, 31 Aug 2022 10:16:00 GMT

This invention is a new polymer-based heart valve designed to reduce stress on the leaflets of the valve while in use in the human body, providing for longer-term durability compared to other polymer-based valves. Background: According to the CDC, heart disease is the leading cause of death in the United States: about one in every four deaths is due to heart disease. Some heart conditions can be treated through replacement of heart valves. However, existing replacement heart valves have limitations. Tissue-based replacement valves, which are taken from other humans or animals, tend not to las...

Method For The Efficient Generation Of High Order Hermite Gaussian (HG) Modes In A Laser Cavity

JianlingL@tla.arizona.edu — Tue, 30 Aug 2022 12:47:01 GMT

This technology is a method to generate higher order transverse laser modes. This method uses a combination of optical and/or electrical pumps and a VECSEL chip (vertical external cavity surface emitting lasers). Background: There are broad range of applications for higher-order lasers. However, due to low output power and/or large device size the current technologies are not practical. This new method will create tunable high-quality output power while still maintaining flexibility. By focusing on resolving these two concerns, this technology will have significant impact on various...

Iron-targeting to stop cancer growth in malignant cells

JianlingL@tla.arizona.edu — Thu, 11 Aug 2022 09:10:49 GMT

This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Following cellular uptake, the tetrazolium compounds of the present invention undergo reduction to produce metal-binding formazan species that are capable of in vivo binding of various metals. In this approach, the prochelator compound forms an active metal-binding chelato...

MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention

JianlingL@tla.arizona.edu — Wed, 27 Jul 2022 16:40:45 GMT

This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity. Background: The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created opportunities for new drug targets for these conditions. Previous studies have implicated low levels of selective melanocortin-4 receptor (MC4R) in both obesity and aging/cognitive decline. In this technology, the inventors purpose the use of a ...

Receiver Design for Entanglement-Assisted Classical Communication

JianlingL@tla.arizona.edu — Tue, 19 Jul 2022 17:01:00 GMT

This technology is a new type of receiver for entanglement-assisted classical communication, that is ideal for applications with noise or weak signal strength, and improves communication rates over existing solutions. Background: Entanglement-assisted classical communication describes the process by which the properties of quantum entanglement (such as quantum teleportation and superdense coding) are used to assist in the transmission of traditional information (such as text). This method of communication can be particularly valuable for applications where a high level of confidentiality is ...

Programmable Waveguide Device

JianlingL@tla.arizona.edu — Tue, 19 Jul 2022 16:29:21 GMT

This technology describes a programmable optical waveguide device that can be configured to operate as an optical switch, optical attenuator, interferometer, mode transformer and optical computer. Background: An optical waveguide is a physical structure that guides electromagnetic waves in the optical spectrum. Common types of optical waveguides include optical fiber and planar dielectric waveguides made of low-loss dielectric materials such as plastic and glass. Optical waveguides are used as components in integrated optical circuits or as the transmission medium in local and long haul optic...

Real Time CGH Calculation and Beam Tracking

JianlingL@tla.arizona.edu — Tue, 19 Jul 2022 16:25:04 GMT

This technology is a new method of steering laser beams in LiDAR systems. Based upon live camera information, it creates a computer generated hologram (CGH) used to focus the LiDAR scans on specific areas of interest, improving real-time detection and tracking of important objects in the field of view. Background: Light Detection and Ranging, or LiDAR, is used to determine the range of an object by bouncing a laser off a distant object. When the laser is scanned over multiple areas in sequence, it can begin to map the shape of an object and track its movement. These techniques are used in man...

System for Figuring Thin Mirrors Using Ultrashort Laser Pulses

JianlingL@tla.arizona.edu — Tue, 19 Jul 2022 15:47:23 GMT

The inventors have developed an optical system, laser spot position determination process, and calibration process for deterministically figuring thin mirrors by creating stress inside the glass substrate (or other material transparent to the laser beam wavelength) using an ultrashort pulsed (USP) laser. This process is especially useful for low spatial frequency correction of optical components with high aspect ratio (lateral size to thickness ratio). Background: Current solutions focus on elementary volumes and elements of an optical substrate or wafer. In contrast, this technology allows f...

Multi-Zone Diffractive Mask for Fine Control of Light Amplitude and Phase

JianlingL@tla.arizona.edu — Mon, 18 Jul 2022 11:55:03 GMT

This invention is a mask that can be used in an optical setup to diffract an amount of light based on wavelength. The mask is placed within the focal plane to solve the size-chromaticity problem by using this phase technique. This will achieve better resolution and high start to planet contrast. Background: In the study of the Sun's corona, light from the central portion of the sun needs to be blocked while the light of study needs to be transparent. A coronagraph achieves this. In addition, exoplanet finding is extremely popular but is also negatively affected by unwanted starligh...

MEMS-Based Hybrid Beam Steering for LIDAR

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 16:19:33 GMT

This technology is a LiDAR (light detection and ranging) beam steering system designed to increase scanning range while keeping quality resolution using a microelectromechanically (MEMS) controlled mirror. This allows a single focused beam to be reflected over multiple angles, greatly increasing the possible scanning range. The mirror is specially designed to maintain the resolution of the beam over these many angles. Background: LiDAR sensing for autonomous vehicles is undergoing a huge amount of research and development to bring down costs and product size, while keeping image res...

Pseudo Phase Conjugate Image Transfer Device for Head Worn Display

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:59:00 GMT

Researchers at the University of Arizona have applied a novel pseudo-phase conjugate technique to the design of a ghost-free and nearly aberration-free head up display. The Pseudo-phase conjugate Head-up Display (PHD) optical engine enables image transfer in an ultra-thin form factor with transparent devices which can be buried inside prescription glasses and sunglasses. Background: In conventional HUDs, the optical medium through which the image information propagates is limited to free-space or image guide optics, employing total internal reflection. This requires relat...

ASLM Multi-Display

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:58:12 GMT

This technology is a new method that illuminates digital micromirror device (DMD) with focusing, homogenous illumination with cone angle/numerical aperture/F-number configured to prevent contaminated light to enter incorrect pupils. The technology has one input pupil and multiple diffraction order pupils that produce a multi-display from just one projector. Background: Digital micromirror device (DMD) is an array of micromirror pixels that traditionally are an alternative between ON and OFF positions that direct towards or away from a projection lens for an image projection. Tr...

Digital Fringe Projection and Multi-Spectral Polarization Imaging for Rapid 3D Reconstruction

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:57:29 GMT

This invention embodies methods, devices and systems that utilizes Digital Fringe Projection (DFP) to generate three dimensional (3D) images of an object based on measurement of polarizations and/or color light in a single shot. Unlike conventional techniques, which require sequential measurements, the novel systems acquire high dynamic range information in a single shot and can be applied to rapidly changing scenes and objects. It's fast, portable, compact, and has low power consumption. Background: Three dimensional (3D) imaging techniques have applications in industrial ...

Computational Photographic System for Depth Resolution Imaging

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:56:49 GMT

This invention is a method for acquiring 3D imagery using an adaptation to existing SLR camera systems that allows for full 3D imagery to be obtained without sacrificing the inherent imaging capability of the camera. This adaptation allows for relatively low cost implementation of 3D technology into already existing camera systems. Through the use of computational photography, wavefront encoding, and structured illumination, 3D images can be acquired rapidly for use in both video and photographic imaging applications. Background: 3D display technology is becoming increasingly im...

Tactical Lighting Device

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:56:17 GMT

This invention is a tactical lighting device that accomplishes the same purpose of a stun grenade or flash bang, without the blast and concussion. Background: Flash bangs or stun grenades are commonly used in law enforcement and military operations due to their effectiveness at subduing and disorienting targets from the bright light and sound. Their effect however has the power to disorient the user, as well as ignite flammable materials or burn skin. Applications: Military and law enforcement Advantages: Inexpensive Reusable Non-lethal

Software Code for Modified Prime Code Family for Optical CDMA

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:55:50 GMT

Researchers at the University of Arizona have developed a novel spreading/address code family for high-speed, large-capacity wired/wireless or optical communications. The novel "transposed modified prime codes" (T-MPC) have specific correlation properties and flexible code size, length and weight. This code family is comparable to existing spreading code families in terms of correlations, bit-error rate (BER) performance and cardinality, but increases the cardinality up to twice that of existing prime code families. Thus, a greater number of users can be accommod...

Polarization State Scrambler Using Birefringent Phase Mask

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:55:01 GMT

A University of Arizona researcher has designed a device to efficiently convert partially polarized and polarized light into light having randomly distributed polarizations, or more generally, into output light having a plurality of polarizations. The passive device provides almost instantaneous conversion of polarization, as opposed to the current methods which use a modulator that requires a signal generator and drive electronics. The novel device will be very useful for telecom, imaging, and illumination. Background: In fiber optic communication systems, light signals a...

Optical Compensation of Mechanical Effects for Holographic Digital Data Storage System

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:54:34 GMT

University of Arizona researchers have invented a Holographic Digital Data Storage System (HDSS) that employs optical components to compensate for mechanical instability. This invention calculates errors introduced during the recording process, then compensates for those errors during the reading process. Background: Holographic Data Storage Systems (HDSS) have the potential for high-capacity, high-bandwidth data storage and transfer. However, these systems require tight tolerances to function properly. Vibrations within certain system components, like mirrors, can cause errors in th...

High-Throughput Manufacturing for PIC Polymer Waveguide Connection Fabrics

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:53:42 GMT

This invention is a low-cost high-throughput method of connecting silicon photonic chips to one another. The method is active and robust, taking into account the tolerances and variations of the PIC configurations. It is also rapid, accurate, immune to large dimensional variation, and amenable to rework. Background: Photonic integrated circuits (PICs) combine multiple photonic functions into a single photonic chip. A fundamental problem in the optical packaging of PICs is the connection of optical waveguides of various forms, with modefield diameters (MFDs) of 10 micro...

Wavelength Diversity Detection for Holographic Data Storage System

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:53:15 GMT

The technology is a method to reduce noise in third generation technology optical discs that record up to 8TB of information. A technique responsible for the increase in the signal-to-noise ratio uses a wide spectrum laser to sense noise and respond in a way that enhances the signal. Background: Optical discs can only hold so much information before the signal is degraded. Holographic data storage is capable to store up to 16TB of information. Up to now, second generation (8TB) technology is feasible. Applications: Data storage Advantages: The technology makes 16TB ...

Buttressed Haptic Design for Accommodating Intraocular Lens

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:51:23 GMT

This invention is a buttressed haptic that actuates the mechanically accommodating intraocular lens from the eye’s ciliary muscle. The technology allows the eye to change its focal distance using the eye’s natural mechanism of ciliary body muscle tension. The haptic receives radial tension from relaxation of the ciliary muscle to provide anterior vectored force on the lens, altering its focusing power. The haptic does not use barbs and is buttressed by overlying tissue to prevent the intraocular lens (IOL) from buckling and is thick to increase the structural stiffness. The b...

Snapshot Plenoptic Imaging Spectrometer

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:50:48 GMT

This technology is a specialized plenoptic imaging system that is capable of not only gathering spatial and angular information but also hyperspectral and polarization information. The configuration of the system is that of a snapshot imager, which greatly increases its practicality and ease of use. Background: Advanced camera systems generally rely on multiple imaging modalities to obtain cutting-edge information from a scene. One type of advanced imaging system, known as the plenoptic camera, is able to capture not only color and spatial information, but also angular information ab...

Fast Volumetric Imaging of Fluorescent Tissue Structures and Activities

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:50:18 GMT

Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps). The invention breaks away from the traditional plane-scanning approach and implements volumetric projection imaging instead. Background: In order to study complex dynamics of tissue in live animals, ideally the microscope needs to maintain the sub-micron resolution in deep tissue to resolve activities in sub...

Camera-Based Surgical Microscope with Display

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:49:53 GMT

This invention is a compact surgical microscope that provides an increased depth of focus and wide field of view from various angles of the surgical field. Information from multiple wavelengths, including visible and NIR can be overlaid on a single display monitor. The monitor is mounted so that several people can view it at the same time, with no neck or shoulder strain. Background: Conventional surgical microscopes designed for microsurgery take some time to master and only allow up to two users. In addition, surgeons are constantly having to fix their eyes on the eyepiec...

A Multi-Functional Three-Dimensional Microscopic System with Structured Illumination and Optical Depth Scanning

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:49:24 GMT

This technology is a telecentric microscope design that reconciles the resolution vs. depth of field issues associated with microscope systems. The microscope's design maintains constant system magnification while it performs a depth scan with an electrically controlled vari-focal lens. Background: The classic tradeoff between optical resolution and depth of field in microscopy forces a conventional system to take measurements at different depths and then reconstruct three-dimensional data for an extended depth of field (EDOF), a time-consuming process due to the limit...

Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:48:59 GMT

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and time-gated detection, the microscope has improved lateral and axial resolution. Background: Current super-resolution microscopy allows live 3D imaging of cellular processes at tens of nanometer resolution, but lacks super-resolutio...

Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:48:24 GMT

A new lifetime imaging system that can fully measure the FRET network between five fluorescent labels in a single image scan has been developed at the University of Arizona. This technology is capable of performing hyper-dimensional lifetime imaging on multiple excitation wavelengths simultaneously, allowing for previously not achievable FRET imaging of cellular processes. The system also is cost-effective as no pulsed lasers or time-gating mechanisms are required for collecting images, and the design can easily be configured for any fluorophore combination. Background: Real-time stu...

Frequency Domain Reconstruction System for Microgrid Imaging Polarimeters

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:47:54 GMT

Researchers at the University of Arizona have developed the concept for a camera system that is able to perform polarimetric imaging with ease while simultaneously implementing instrumentation that reduces polarization artifacts. The system uses technology currently existing in handheld cameras to perform polarization imaging in a novel way that allows for quick image acquisition as well as rugged design. The camera is run with one-click operation and a rapid four-image sequence acquisition. This system has potential to be used in a myriad of applications ranging from medical imaging to milit...

Parallel Multi-Point Scanning Confocal Imaging

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:47:30 GMT

Researchers at The University of Arizona's James C. Wyant College of Optical Sciences have designed a confocal microendoscopic multi-point scanning system. This system has approximately the same resolution of a single point scan system while maintaining the high frame rate of the slit-scan system at 30 fps. A prototype has demonstrated that for a 0.430-mm field of view, the in-plane resolution is approximately 3 µm, and the axial resolution is 25 µm. This multi-point scanning system is suitable for fluorescence confocal imaging and can be used for turbid samples. Furtherm...

Quantitative Large Area Binding Sensor For Detecting Biomarkers

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:46:50 GMT

Researchers at the University of Arizona have developed a lens-free holographic microscope (LFHM) for observing and quantifying target biomarkers in a solution, including targets with a large dynamic range in concentration. LFHM can be used to detect microscale targets (e.g., bacteria and cells) and nanoscale targets (e.g., viruses, DNA strands, and cancer biomarkers). Advantages: Can image a large range of target sizes Accommodates a large dynamic range in concentration Has a large field of view Applications: Cancer biomarker detection Status: issued U.S. patent #11...

Multi-Resolution Foveated Laparoscope

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:46:23 GMT

Researchers at the University of Arizona have developed an optical design for laparoscopes that can obtain wide angle and high magnification images of a surgical area in real time. The two images enable seamless registration between the low and high-resolution images, providing surgeons with the best of both worlds. In addition, the innovation enables flexible adjustment of the probe length and offers spatial resolution more than nine times better than state-of-the art endoscopic imaging technology. Background: Current state-of-art laparoscopes suffer from a tradeoff between spatial re...

Time-Resolved Fluorescence Measurements in Real-Time

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:45:24 GMT

A prototype instrument that uses fast switching photomultiplier tube (PMT) to acquire real-time time-resolved fluorescence lifetime data has been developed and tested at the University of Arizona. The PMT detector can collect fluorescence data at rates as high as 200 MHz without the production of switching transients. The circuit system also demonstrates a better signal integrity performance, a greatly improved bandwidth, and a faster transient response than any other approach to this problem. This system is capable of generating real-time fluorescence lifetime curves for molecules that have ...

Sub-Cellular Imaging and Manipulation via Hyper-Numerical Aperture Imaging Surfaces

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:44:25 GMT

High spatial resolution and detection of sub-cellular physiology (like respiration) is achieved using a near-field imaging surface that can be manipulated mechanically inside living biological matter. This new near-field probe is photon efficient, unlike most near-field scanning probes, and is a true imaging probe, not a point source or point collector. The mechanical structure of the imaging tip allows navigation of the probe through biological matter, including inside cells. The resolution promises to be comparable to early SEM studies, but with the ability to image dynamically in livi...

Coded-Aperture System for Planar Imaging of Volumetric Sources

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:41:24 GMT

This invention is a method for obtaining parallel projections (i.e. 2D planar images) of a 3D object without the use of a parallel bore collimator while offering improved resolution and decreased resolution degradation with increasing object depth. The method involves measuring the photon flux of a gamma photon emitting source from within the subject’s body in a novel fashion, and processing these measurements with computer software that utilizes a unique mathematical process. Background: Nuclear medical imaging encompasses scintigraphy (using internal radionuclides ...

Structured Chromatic Light Sheet Microscope

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:37:33 GMT

This technology is a novel microscope that uses the chromatic slit confocal detection with chromatic light sheet illumination to improve the image resolution and contrast over a large imaging depth. Background: Deep tissue imaging is important for detecting and diagnosing epithelial diseases. Current scanning systems are bulky, expensive, and complex. To create a low cost hand held imaging system, a chromatic light sheet microscope with other features is to be used to provide enhanced and volumetric images. Applications: Tissue imaging Advantages: Ease of use Inexp...

Low-Cost, Compact Chromatic Confocal Microscope

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 15:37:00 GMT

Researchers at the University of Arizona have designed a high light efficiency, high resolution confocal microscope that has no moving parts. The new design is high-speed, has axial scanning, is compact, and low-cost. Background: Current state-of-the-art scanning confocal microscopes use axial and lateral scanning techniques, such as DMDs for lateral scanning and a tunable light source and chromatic objective lens for axial scanning. These methods are faster than prior efforts, but are expensive and have low light efficiency. MEMS pinhole arrays have also been used for sna...

Inverse Optical Design of the Human Eye

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:34:13 GMT

Researchers at The University of Arizona and the National University of Ireland, Galway, are developing an innovative method to estimate the full set of patient-specific ocular parameters using wavefront sensors. This 'inverse optical design' method maps the entire eye and shows potential for very low uncertainties. It promises a complete patient-specific eye model, providing substantial improvements in vision science and ophthalmology such as vision correction, retinal imaging, and surgical procedures, enabling research and applications previously unapproachable. The 'inverse opt...

A Mechanism and Method for Synthesis of a 2-D Gamma-ray Pinhole Projection Image from a Plurality of Slit Projection Images

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:33:36 GMT

This invention is a 3D medical imaging technique that incorporates single photon emission computed tomography (SPECT) to image radioisotope distributions, which are generally used to detect/monitor cancer, drug delivery, etc. This imaging technique uses SPECT to take 2D and 3D tomographic images of radioisotope distributions, both of which can be analyzed separately at high resolution. In addition, the 2D data can be recovered, analyzed and sorted into groups by the angles where the images were taken. This technique can be used in preclinical and clinical subjects. Background: SPECT ...

Identification and Control of Myopic Progression Using Distortion

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:32:17 GMT

This invention relates generally to myopia and myopic progression, and more particularly to imaging systems and non-invasive methods for identification and characterization (quantifiable measurement of the amount, type and orientation) of ocular distortion in the human eye, in order to detect the onset or progression of myopia and facilitate control of myopic progression. The methods extend to measuring [characterizing] retinal shape, including the radius and conic shape. Background: Visual acuity is the measure of the eye to perfectly resolve images from the real world ont...

Trapezoidal Shim for Segmented Optics Assembly

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:31:45 GMT

Researchers at the University of Arizona have designed a paradigm-shifting space telescope technology. The technology produces ultra-lightweight, transmissive lenses that are fabricated economically in segments. The novel aspects of the technology facilitate quick assembly with very high precision alignment. Background: Improvements in space telescope technology are needed. For example, mirror systems may be heavy, costly, and may comprise transmission loss and reduction in light throughput. Also, segmented mirror system has very sensitive alignment and assembly toler...

Kinematically Engaged Yoke System

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:31:05 GMT

This technology is a new alignment, co-phasing and assembly approach called KEYS (Kinematically Engaged Yoke System) that uses intrinsic surface profiles of multiple order diffraction (MOD) optical segments. The technology is composed of a harness that has negatively shaped semi-kinematic “keys” which fits the MOD-side-step-like mechanical profile that is manufactured with high optical precision. Background: Improvements in space telescope technology are needed. For example, mirror systems may be heavy, costly, and may comprise transmission loss and reduction in light throug...

Hybrid MOD-Enmat Lens

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:30:23 GMT

Researchers at the University of Arizona have designed an optical device comprising a multiple-order diffractive Fresnel lens (MOD-DFL) and an achromatizing compensation mechanism that reduces refractive dispersion created by the MOD-DFL, thereby reducing the focal range of the MOD-DFL. A method is also provided of using the optical device in an image processing system to obtain images of an object and processing the images to perform image enhancement. Background: A multiple-order diffractive Fresnel lens (MOD-DFL) operates over a set of higher diffracted orders where eac...

Space Deployable Spectrometer with Large Collection Area

JianlingL@tla.arizona.edu — Thu, 14 Jul 2022 14:29:04 GMT

This invention is a highly scalable optical design that will allow the construction of deployable space telescopes with collecting areas that are an order of magnitude greater than the current state-of-the-art and with greatly reduced production and launch costs. The design includes a novel spectrometer capable of surveying transiting earth-sized exoplanets for atmospheric bio-signatures. The technology can fundamentally impact space-borne remote sensing, earth observations, and astronomy. Background: Current state of the art space telescopes are designed with either refractive and/o...

Aqua Blue Method for Mining Icy Regolith on the Moon

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:57:16 GMT

This invention proposes a plan and method by which to begin mining operations for resources of interest, such as icy regolith on the Earth’s Moon. Background: As settling activities on Earth’s Moon continue to become more feasible, there has long been interest in what raw materials can be extracted or mined and how. From the diverse mineral sources that are potentially available on the surface or underneath, one of the key materials that remain as the top interest for exploitation is icy regolith. Icy regolith is iced over mixtures of powdery dust and broken rock that is usually f...

Luna Mine Planning

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:56:49 GMT

This invention proposes a plan and method by which to begin mining operations on the Earth’s Moon. Background: As settling activities on Earth’s Moon continue to become more feasible, there has long been interest in what raw materials can be extracted or mined. From the diverse mineral sources that are potentially available on the surface or underneath, one of the key materials that remain as the top interest for exploitation is water ice. In this invention, the authors propose a production-oriented approach for a straightforward and effective production cycle for extraction of w...

Quantum Receivers for Entanglement Assisted Communications and Sensing

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:42:06 GMT

Entanglement Assisted Communication (EACOMM) and quantum computing is the future for many different industries. The unique capabilities of being able to calculate some superposition of atoms between 0 and 1 is a huge asset for complex computing. While the channel capacity for EACOMM has been theoretically demonstrated, optimal quantum receivers have yet to be determined. In order to realize the optimal efficiency and capability of EACOMM, quantum receivers must advance in tandem with the other hardware involved in EACOMM. This technology is a step in realizing the capability of EACOMM and does...

GateKeeper: In Space Debris Detection Technology

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:40:29 GMT

Invention: Popularly predicted by Donald Kessler, the Kessler Effect seems to be more of a descriptor of the current low-Earth orbit conditions rather than a prophetic warning. The idea is that there are going to be so many satellites and other debris in low-Earth orbit that collisions between objects may become inevitable. Because of the high density of space debris, those inevitable collisions could cause a cascade where any collision creates a greater likelihood of future collisions. The reality of increased space debris makes space travel and launches more difficult. Furthermore, the sate...

Silver-Silver Sulfide Reference Electrode

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:36:33 GMT

This invention is a new reference electrode that was prepared by anodizing (electrochemically oxidizing) silver metal in a sodium sulfide solution (SSSE). This results in a silver metal wire coated with silver sulfide. The electrode is extremely stable. The measured potentials for SSSE versus SSCE during two experiments in 1 molar KCl in air were 0.883 and 0.886V. The test for SSSE versus SSCE run in NaCl-KCl molten salt at 800C against the high temperature SSCE was measured at 0.866V. The invention is also capable of operating at lower temperatures than typical reference electrodes, includin...

PowerDown (tm) Electric Value Indicator

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:34:14 GMT

PowerDown is a unique means of providing electrical power grid information to the consumer to increase overall energy efficiency. This information will be relayed to the consumer through a simple LED system to inform them of current usage rates in a simple and easily understandable means. This helps to empower the consumer to become more involved in their energy consumption habits by receiving real-time information. Background: Most consumers are not aware of their energy usage until receiving an electric power consumption bill. While most innovations in this industry are focused on renewabl...

Phononic Crystal Material that Creates Acoustic and Elastic Flatbands for Acoustic and Vibration Dampening Applicaitons

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 13:28:52 GMT

This invention is generally directed towards phononic crystals (PCs) more specifically to phononic metamaterials suitable for attenuating mechanical vibrations, as well as acoustic vibrations that propagate through a medium. Background: Phononic metamaterials enable the manipulation of both elastic and acoustic waves in different media, from attenuation (including absorption and reflection) to coupling, tunneling, negative refraction, and focusing. In particular, the attenuation of vibration such as vector mechanical vibrations through a solid, or a scalar acoustic vibra...

Sensitive, Low-Cost Detection of SARS-CoV-2 from Clinical Saline Gargle Samples Using Smartphone Fluorescence Microscope

JianlingL@tla.arizona.edu — Fri, 24 Jun 2022 09:06:06 GMT

This invention is a method of rapidly detecting SARS-CoV-2 in clinical saline samples using a smartphone fluorescence microscope-based immunofluorescence. This method can detect samples of SARS-CoV-2 in saline gargle solutions down to 10 ag/μl (below single copy level). A saline sample is collected, loaded onto a paper-based microfluidic chip, and analyzed using a smartphone-based fluorescence microscope. The method uses lower-cost materials to detect virus samples in a saline solution and is more sensitive that similar rapid kits. The sample-to-answer assay time is less than 20 minutes. Th...

Plagiarism Workshop for Law Students

JianlingL@tla.arizona.edu — Fri, 17 Jun 2022 14:24:28 GMT

This innovation is an online plagiarism workshop consisting of eight self-paced modules. Topics covered include what plagiarism is and why it is wrong, why people plagiarize, how to properly quote, paraphrase, and cite the work of others, cultural perspectives on plagiarism, consequences of plagiarism, and components of plagiarism specific to law. Each module contains written, audio, and video materials for learning, and most modules contain a short quiz to assess gained knowledge. A post-test will be taken after completing all eight modules, and a certificate will be awarded upon completion....

A Small Molecule Kinase Inhibitor that Regulates RNA Degradation and Inhibits Tumor Growth and Invasion

JianlingL@tla.arizona.edu — Thu, 16 Jun 2022 13:20:41 GMT

This invention describes a novel potential therapeutic for several cancers that inhibits tumor growth and invasion by regulating RNA degradation. Background: There have long been attempts to find new cellular mechanisms that can be targeted for a wide range of cancers without the notable and significant toxic effects of existing therapies like chemotherapy or radiation treatment. Recently, it has been validated by the inventors and other literature that regulating RNA decapping and degradation can play a significant role in controlling the growth and invasion of several types of cancer...

Deep Learning-Based Hyperspectral Imaging

JianlingL@tla.arizona.edu — Wed, 08 Jun 2022 09:15:32 GMT

This technology is a pairwise-image-based hyperspectral convolution neural network (pHSCNN) that works to recover hyperspectral images from a pair of RGB images to improve their fidelity. The technology captures sequentially via a color sensor paired with and without an optimized optical filter in front of the imaging lens. This filter also works to improve overall system performance. The technology proposed can be applied to biomedical, remote sensing and computer vision applications to improve the resolution of hyperspectral images collected. Fidelity is a measure of how well two images may...

Low Cost Flame Retardant Polymers from Low Cost Olefinic Comonomers

JianlingL@tla.arizona.edu — Mon, 06 Jun 2022 14:12:26 GMT

This technology is an approach to using sulfenyl-halide polymerization with olefinic comonomers to prepare a new class of intrinsically flame-retardant polymers for the production of a wide range of thermoplastics, thermoplastic elastomers, and thermoset materials. Materials prepared with this technology have afforded a V0 UL-94V flame retardancy rating and have attractive properties for processing and thermal stability. Background: Synthetic organic plastics are a critical class of material in modern day society due to their low cost, excellent thermomechanical properties, ...

New Polysulfide Materials derived from Sulfur Monochloride for Flame Retardant Polymers

JianlingL@tla.arizona.edu — Mon, 06 Jun 2022 13:54:17 GMT

This technology is an approach to using sulfenyl-halide polymerization with olefinic comonomers to prepare a new class of intrinsically flame-retardant polymers for the production of a wide range of thermoplastics, thermoplastic elastomers, and thermoset materials. Materials prepared with this technology have afforded a V0 UL-94V flame retardancy rating and have attractive properties for processing and thermal stability. Two compositions of polyhalodisulfides were tested for flame retardancy by an established ASTM flame test for polymeric materials and were found to rapidly self-extinguish wit...

Vascular Plug

JianlingL@tla.arizona.edu — Wed, 25 May 2022 11:00:41 GMT

This technology is a small silicon item that is designed to fit in blood vessels to stop blood loss by plugging the vessels to allow for ligation of the vessel during surgical procedures. Prototypes of two durometers have been made. These plugs will come in slightly varied sizes to allow them to fit in any vessel. Background: The World Health Organization estimates that 234.2 million surgical procedures are performed every year worldwide, with around 50 million of those procedures happening within the United States during recorded years. One of the main problems that is faced during surgery i...

Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation

JianlingL@tla.arizona.edu — Tue, 24 May 2022 13:38:53 GMT

A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling stable compounds that then could release reactive species at biological pH, reducing intracellular environment, or via enzymatic release to elucidate biochemistry. This invention comprises a class of chemistry and method of use for small mol...

A Method for Characterizing Adeno-Associated Virus Capsids with Thermal Unfolding and Mass Spectrometry

JianlingL@tla.arizona.edu — Mon, 23 May 2022 13:58:57 GMT

This invention describes modulating the temperature of the solution in an electrospray needle prior to charge-detection mass spectrometry (CD/MS) to enable discrimination between the individual stabilities of multiple forms of viral particles that may be present in an AAV preparation. This increased discrimination provides the operator with a unique ability to determine the stability of the fully assembled viral particles even if the AAV preparation comprises partially filled virions, over-filled virions, and/or various assemblies of capsid proteins lacking a nucleic acid cargo. Backgro...

Pre-Enrollment Breastfeeding Consultation Guide

JianlingL@tla.arizona.edu — Fri, 20 May 2022 06:16:22 GMT

This invention is a consultation guide intended to drive a more productive conversation between the childcare center and the family to increase support for breastfeeding mothers and consequently extend breastfeeding duration.

Animal Attitudes Survey

JianlingL@tla.arizona.edu — Fri, 20 May 2022 05:52:41 GMT

This is a survey that is to be used as an assessment tool to measure various human attitudes toward animals. This is the first survey of its kind to measure a broad spectrum of thoughts, feelings, and behaviors towards nonhuman animals. This tool will be used to assess career aptitude for individuals intending to pursue a career involving animal interactions. Background: There is a high cost associated with choosing a career path or field of study that is not well suited for an individual’s skills or interests. The average student loan debt associated with graduate school is over $70,00...

An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs

JianlingL@tla.arizona.edu — Fri, 20 May 2022 05:43:48 GMT

This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications. Background: RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain RNAs for degradation, and by extension, gene knockdown. This technology has a wide range of potential research and clinical applications. In this technology, the inventors propose the use of a novel system that allows for piRNAs for gene silencing...

Consumer Optics with Low Cost Polymers

JianlingL@tla.arizona.edu — Wed, 18 May 2022 14:03:18 GMT

This invention describes a range of low-cost polymer compositions and method of making for high index, high Abbie number consumer optics. Background: The consumer eyewear global market estimated at greater than $100 billion. Current optical polymer technology revolves around well-established thermoplastic or thermoset polymers, including polycarbonates and others. State-of-the-art known optical polymers are limited by a trade-off between the desire to have high refractive indices, high Abbe (transparency) numbers, and low material cost. There remains a technological need for...

User-Space Emulation Framework for Domain-Specific Soc Design

JianlingL@tla.arizona.edu — Thu, 12 May 2022 13:40:28 GMT

This technology uses Linux-based emulation framework to provide an ecosystem for hardware-software co-design of Domain-specific SoCs (DSSoCs) and enable their rapid evaluation during the pre-silicon design phase. Background: As technology scaling becomes a challenge, System-on-chip architects are exploring DSSoCs to effectively balance performance and flexibility. DSSoC architectures are characterized by a heterogeneous collection of general-purpose cores and programmable accelerators tailored to a particular application domain. The heterogeneity of systems-on-chips makes it very difficu...

Hierarchical and Lightweight Imitation Learning for Power Management of Embedded Socs

JianlingL@tla.arizona.edu — Thu, 12 May 2022 13:38:16 GMT

This technology involves an imitation learning based power management system for use in embedded systems-on-chips (SoCs). Background: As technology advances, systems-on-chips (SoCs) need to be able to operate more efficiently to keep up with multiple rapidly adapting technologies. Many SoCs struggle with dynamic power management and need to be able to adapt to runtime decisions for multiple objectives. However, current systems do not have these capabilities. This technology improves upon current state-of-the-art solutions in terms of energy efficiency and runtime aware decisions. Appli...

Runtime Task Scheduling using Imitation Learning for Heterogeneous Many-Core Systems;

JianlingL@tla.arizona.edu — Thu, 12 May 2022 13:32:52 GMT

This technology involves task scheduling to optimally utilize the processing elements at runtime using imitation learning. Background: Harvesting the full potential of many-core systems-on-chips is difficult. The goals are to minimize execution time, power dissipation, and energy consumption. This technology intends to solve this problem through assigning tasks to specific processing elements using imitation learning instead of the commonly used reinforcement learning. Applications: Optimized processing elements System-on-Chips Advantages: Minimized execution time Less p...

Use of DNA Containing Specific Sequences to Prevent Neisseria Gonorrhoeae Infection

JianlingL@tla.arizona.edu — Fri, 06 May 2022 09:49:45 GMT

This invention encompasses an antimicrobial that can treat disease caused by the pathogen Neisseria Gonorrhoeae (Ngo). The compounds described can be incorporated into commercially available personal lubricants for individual use. Background: N. gonorrhoeae (Ngo) causes over 160 million new cases of gonorrhea each year globally; in 2018, it caused 1.6 million new infections in the US. This bacterial pathogen primarily infects the urogenital tract and oropharynx of men and women. It also establishes asymptomatic infections at high frequency; up to 60% of cervical infections are asymptoma...

Genes and Polypeptides of Neisseria Musculi that can be used to Evaluate Vaccines and Anti-Bacterial Compounds against Infection by Pathogenic Neisseria Species

JianlingL@tla.arizona.edu — Fri, 06 May 2022 09:21:52 GMT

A set of Neisseria musculi (Nmus) genes have been identified which promote Nmus infection and persistence in its natural host, the mouse. These genes have never been described before, so the in-host function of their encoded proteins is unknown. These genes are present in the human pathogenic Neisseria, N. meningitidis and N. gonorrhoeae. These genes and/or their encoded proteins are therefore potential targets for vaccines and antimicrobials against N. meningitidis and N. gonorrhoeae. Background: The proposed technology can be potentially used treat both N. meningitidis and N. gonorrhoeae by...

Peptides Targeting Inositols Mediated Proliferative Signaling for Treating Cancers and other Proliferative Disorders

JianlingL@tla.arizona.edu — Thu, 05 May 2022 14:57:47 GMT

This invention describes a method that efficiently stops the growth of cancer cells or over-proliferative cells without causing adverse cytotoxic effects on the body’s healthy organs and tissues. This technology focuses on the IMPA1/RAGE complex and its ability to control cell proliferation. Background: Proliferative disorders include a wide variety of diseases, such as cancer, atherosclerosis, rheumatoid arthritis, psoriasis, idiopathic pulmonary fibrosis, scleroderma, and more. Hundreds of thousands of individuals suffer from these disorders. Cell proliferation can be triggered by the...

Sex and APOE Genotype Precision Therapeutic Targets Discovery for Alzheimer’s Disease

JianlingL@tla.arizona.edu — Thu, 05 May 2022 14:53:03 GMT

This technology encompasses a formulation for patient subgroup-specific supplement for the treatment and therapy of Alzheimer's and other neurodegenerative diseases. These formulations can range in delivery method (food, drink, pill) and can be specific to patient subgroups. Background: Alzheimer’s disease is a progressive, neurodegenerative disorder with few effective therapies and no cures. Additionally, cases and prevalence of Alzheimer’s disease are only projected to rise in the coming years. One of the challenging parts of Alzheimer’s disease is that it impacts diff...

Peptide-Based Modulators of HMGBl Activity Protect Against Cell Damage and Inflammation

JianlingL@tla.arizona.edu — Thu, 05 May 2022 14:42:30 GMT

This technology assists with the inhibition of HMGB1 to decrease the body’s inflammatory response, which occurs when the HMGB1 protein binds to DNA and TLR4. By decreasing HMGB1 binding to DNA, cell inflammation can be significantly reduced, thus preventing further cell damage. This technology can be used in a large spectrum of diseases, such as: diabetic complications, hypertension, systemic inflammation, acute chronic heart, kidney, and liver diseases. Background: Chronic cell inflammation plays a pivotal role in cell damage and inflammation to the body’s cells is a major ...

Carbon Capture Using Microalgae Cultivated in Scalable Photobioreactors Paired with a Particle Filtration System

JianlingL@tla.arizona.edu — Thu, 05 May 2022 10:31:49 GMT

University of Arizona researchers have developed a method to offset carbon emissions for industries where carbon-neutral operations are particularly challenging (e.g., airlines, shipping). This invention offers a method to offset carbon emissions for industries where carbon-neutral operations are particularly challenging (e.g., airlines, shipping). This invention offers a scalable solution to efficiently extract CO2 from the atmosphere by utilizing a novel combination of a UArizona patented, low-cost photobioreactor system, which has an excellent track record of growing pho...

Flight Duration Enhancement for Single Rotorcraft and Multicopters

JianlingL@tla.arizona.edu — Wed, 04 May 2022 21:03:57 GMT

This invention is an optimization methodology for key dimensions of rotorcraft shroud, nozzle, cover, and turbine designs as well as specific optimized designs that will result in prolonged flight time, reduced damage to the rotorcraft from ground effects, enhanced safety, and reduced noise. The invention seeks to alleviate the shortcoming of the short operability periods of these increasingly popular drones. The prolonging of flight duration of single rotorcraft and other multicopters can occur, through the invention, with a net-zero overall mass increase of the aircraft. Background...

A Web-Based Bayesian Disease Recommender System

JianlingL@tla.arizona.edu — Wed, 27 Apr 2022 10:37:44 GMT

This technology is a disease recommendation system that assesses a given set of diagnoses that a patient has and identifies possible co-morbidities. The system can be used by doctors to discover additional diseases in their patients or by hospitals to discover codes that may have been missed during the billing process. Background: There is significant need for new software and systems to help improve healthcare. As the global population ages and the incidence of chronic disease rises, there is an increasing need to find ways to efficiently provide healthcare and diagnostic services in the mos...

mmWave Radar Based System for Extracting Human Skeleton

JianlingL@tla.arizona.edu — Thu, 21 Apr 2022 14:44:40 GMT

Millimeter-wave technology offers users detailed views of body parts through walls or other obstructions. This invention generates and measures an RF signal (millimeter wave) and processes the data with machine learning to extract and identify body motion within a region. Unlike other systems that focus on breathing or heart rate, this system can distinguish larger-scale motions of specific limbs. This detection system includes both hardware and computationally efficient algorithms to detect motion and interpret it in terms of human skeletal components. Similar patents focus on det...

Quantum-Enhanced Gyroscopes

JianlingL@tla.arizona.edu — Thu, 21 Apr 2022 10:15:04 GMT

This technology is a new type of laser gyroscope that makes use of concepts of quantum squeezing and quantum entanglement to offer improved sensitivity over existing laser gyroscopes. Background: Laser gyroscopes use laser interferometry to measure changes in their rotation or orientation. They use no (or few) moving parts, unlike traditional mechanical gyroscopes which rely on the inertial properties of a spinning wheel or disc to measure rotation. They are most frequently used in the aerospace and defense industries, as they are lightweight, compact, and resilient. However, most laser gyro...

Method of Updating Seeker Platform Attitude to Improve Performance in a Planetary Landing System

JianlingL@tla.arizona.edu — Thu, 21 Apr 2022 10:08:32 GMT

This technology is a technique to improve the accuracy and performance of autonomous planetary landing vehicles. Measurements from a stabilized seeker implementing a sensor capable of range and closing speed measurements is used to construct a velocity field that, when tracked in six degrees of freedom, will bring the lander to a pinpoint soft landing at the designated landing site, at an upright attitude with negligible rotational velocity. This site can either be illuminated by an optical beacon, or can be selected using terrain hazard avoidance software operating on suitable measurements. A...

Entanglement Assisted Communication with Optical Phase Conjugation on Transmitter Side

JianlingL@tla.arizona.edu — Wed, 20 Apr 2022 18:10:26 GMT

Entanglement -Assisted (EA) Communication and Sensing has been advocated by numerous authors as a potential alternative to classical communications, in particular in noisy and low-brightness regime. This technology proposes an EA scheme employing the optical phase-conjugation (OPC) on transmitter side. It shows that the proposed EA communication system, with the transmitter side OPC, significantly outperforms its classical counterpart in low-brightness and highly noisy regime, while employing a classical coherent detection scheme for two-dimensional demodulation. Moreover, the capacity of...

Adaptive Scale Factor Compensation using Predictive Coding

JianlingL@tla.arizona.edu — Wed, 20 Apr 2022 14:21:07 GMT

This technology is a method of compensating for both look angle dependent radome refraction and rate gyro scale factor errors using deep learning technology, significantly improving the accuracy and effectiveness of a guidance and control system. Background: Look angle dependent radome refraction (which can be modeled as a time varying scale factor error applied to the line of sight direction vector) can create a false indication of target motion, potentially destabilizing a guidance and control system. Similarly, rate gyro scale factor errors create a time-varying bias in the integrated rota...

Compressing Ion-Beam Shutter

JianlingL@tla.arizona.edu — Tue, 19 Apr 2022 16:33:00 GMT

The compressing ion-beam ion shutter developed at The University of Arizona is composed of a series of electrically charged screens. By varying the relative voltages on the screens, the flow of ions into the detector chamber is blocked or opened. When the shutter is first opened, ions accumulate between the screens. When the shutter voltage is changed, the accumulated ions are compressed in space and the ion beam approaching the shutter is simultaneously closed. By controlling, (i) the relative voltages and the timing for changing voltage on each screen in the ion shutter, and (ii) the electr...

A Device for Simultaneous Measurement of Pulmonary Ventilation and Metabolic Rate in Neonatal Rodents

JianlingL@tla.arizona.edu — Tue, 19 Apr 2022 11:03:25 GMT

University of Arizona researchers have developed a way of measuring and studying neonatal rodents' breathing activity and metabolic rate simultaneously using this homemade dual chamber technology. This inexpensive and simple tool is also useful for comparing the ventilatory and metabolic responses to various stressors, including hypoxia, acute inflammatory episodes, heat and cold stress, air pollutants, maternal separation, and more in control and test subjects. Background: Pulmonary ventilation testing in small rodents can be very expensive and technically difficult. Moreover, the rate o...

Virtual Reality Systems and Methods for Improving Clinical Outcomes

JianlingL@tla.arizona.edu — Thu, 14 Apr 2022 08:42:34 GMT

The invention provides a virtual reality (VR) experience, including VR goggles and haptic feedback devices, for patients to explain the benefits of a medical treatment or the consequences of non-compliance. The immersive experience seeks to have a greater impact on a patient’s behavior versus a discussion with a healthcare provider alone. Background: The integrations of VR features into healthcare products and rising utilization of digital data in patient care contributes to the establishment of a relatively stable market for VR applications in the U.S. healthcare industry. &...

Systems and Methods of Analyzing Healthcare Data

JianlingL@tla.arizona.edu — Thu, 14 Apr 2022 08:42:03 GMT

This invention includes systems and methods for collecting and analyzing healthcare information to provide complete, automated health records for patients. The analytic system accepts a broad range of raw data which is translated into concepts using knowledge-bases and then applied to electronic health records (EHR). Background: With the shift toward new payment models and the sheer amount of clinical data contained in electronic health records, more and more healthcare groups are looking to analytics solutions for population health management. Healthcare organizations can different...

Health Information (Data) Medical Collection, Processing and Feedback Continuum Systems and Methods

JianlingL@tla.arizona.edu — Thu, 14 Apr 2022 08:41:51 GMT

The Health Information Continuum is a system for collecting and processing HI data for individual patients across multiple health care provider interactions. The system expands the amount and type of data collected by current HI systems to create a more complete representation of a patient’s health. Furthermore, the broad scope of information collected by the Continuum can provide robust summaries of a patient’s health and well-being as well as predictive alerts pertaining to potential health issues. Background: Electronic health records (EHRs) accounted for the largest ...

Experimental Method for Achieving Classical Entanglement in Large Multi-Qubit Acoustic Analogue Systems (Large Multi Phi-bit Systems)

JianlingL@tla.arizona.edu — Mon, 04 Apr 2022 10:17:23 GMT

The invention is an experimental scalable multi phi-bit system using classical entanglement which can be used to enhance quantum computing. The method here exploits the non-linearity of the quantum computing systems to create logical phibits. The number of phibits is not constrained by the domains of the physical state and the approach here also allows for the definition of the space of states which lie the elastic states of multi phibit systems. Because of the lack of physical constraints, the size of space of states is 2^N where N is the number of phibits, which corresponds to an exponential...

Method for Tailings Dust Suppression

JianlingL@tla.arizona.edu — Fri, 01 Apr 2022 12:42:04 GMT

This technology is a new type of treatment that can be sprayed on mine tailings piles to suppress tailing dust from blowing off the pile, thereby preventing erosion and environmental contamination. Background: Tailings are the waste byproduct of ore mining, and consist of fine particles, many the size of dust particles. They are typically placed in large piles or pools for storage and, where possible, eventually reused or reclaimed. However, when tailings sit in a dry, untreated state, many of the smallest particles can be blown away by the wind. This presents an environmental danger, such as...

In-line Analytical Measurements for High-Throughput Manufacturing of Solar Cells, Enhancing Scalability of Next Generation Semiconductor Thin Film Stacks

JianlingL@tla.arizona.edu — Wed, 30 Mar 2022 16:51:52 GMT

A “stick and peel” removable electrochemical probe is used for solvent-free characterization of semiconductor films or optoelectronic devices and configured for use in situ and/or in operando. The invention may be used to analyze electronic materials such as a metal halide perovskite, an organic semiconductor, a nanocrystalline (quantum dot) thin film, metal oxides, a material blend or a device stack. The method may be used to analyze numerous characteristics, such as numbers of defects or defect density, stability, surface composition, band gap, physical structure, electroactivity...

Defect Characterization for Semiconductors, including Perovskites, in Operando or during Manufacturing, using 'Peel and Stick' Probe with Enhanced Sensitivity

JianlingL@tla.arizona.edu — Wed, 30 Mar 2022 16:41:00 GMT

This technology involves the use of a removable ‘peel and stick electrolyte’ probe for detecting defects in perovskite materials. This is an improvement on previous technology that increases sensitivity of defect detection in device-relevant triple cation perovskites. Background: The development of next-generation flexible optoelectronic devices has focused on the incorporation of solution processable lead halide perovskite materials as an active layer because of their high-power conversion efficiency and easy accessibility. In the last decade, the certified power conversion effic...

Variance of Fixed Joint Space Width and Nomogram to Predict Knee Replacement using Measures from Fixed Flexion Knee X-rays

JianlingL@tla.arizona.edu — Wed, 02 Mar 2022 09:06:49 GMT

The cartilage underneath our knees keeps the bones in our legs from rubbing together. Unfortunately for many, this cartilage wears abnormally thin over time and causes physiological problems. If, however, this can be detected before it becomes a serious issue for the patient, then the patient can receive treatments before the painful problem can be fully realized. This technology seeks to aid in just that: assessing the current health and predicting the future health of cartilage in the knees. It works by reading multiple x-rays of the region and then calculating/inspecting the different aspe...

Natural Rubber Vulcanization using Chalcogenide Hybrid Inorganic/Organic Polymers

JianlingL@tla.arizona.edu — Wed, 02 Mar 2022 07:35:11 GMT

Innovative Approaches to Optimize the Therapeutic Benefits of Autophagy Inhibition

JianlingL@tla.arizona.edu — Tue, 22 Feb 2022 09:27:54 GMT

This technology consists of novel, soluble compounds that are to be used to inhibit autophagy that can lead to pathogenesis of many different diseases and health conditions. Background: Autophagy is the process that regulates the degradation of overabundant malfunctioning cellular components. Autophagy is vital for maintaining cell renewal processes; however, unregulated or aberrant autophagy can lead to many health concerns. Aberrant autophagy may cause the pathogenesis of various diseases including cancers, pulmonary hypertension, diabetes, neurodegenerative disorders, aging, heart dis...

Low-Power, Compact Artificial Seismic Source

JianlingL@tla.arizona.edu — Tue, 15 Feb 2022 09:51:37 GMT

This technology is a system to create a shock impulse on the ground. It operates through a gear-motor that rotates a crank which lifts a linear slider. The slider is mounted in a massive body hammer that compresses a concentric spring on the slider shaft when the gear-motor rotates the crank. This causes the crank to rotate freely and the hammer to drop, creating a shock impulse into a strike plate. The use of a one-way bearing prevents any kind of bounce back and chatter in the impulse signal. Background: This proposed technology fills the need to create an active seismic source on interplan...

Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors

JianlingL@tla.arizona.edu — Thu, 10 Feb 2022 09:11:48 GMT

This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors. Background: Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health effects. Accordingly, most antiarrhythmic drugs are ion channel blockers that alter electrical conduction or cell calcium signaling pathways. These drugs alter electrical conduction or cell calcium signaling pathways by affecting so called "e...

Demultiplex Single-Cell Sequencing Data using DNA Barcode Dyes

JianlingL@tla.arizona.edu — Thu, 10 Feb 2022 08:55:25 GMT

This technology applies to single cell RNA sequencing data that is created in parallel (multiplexed) to speed the process. Once the multiplexed data exists, it needs to be recombined into one set (demultiplexed) to be useful. This technology is a new demultiplexing technique that uses dyes combined with DNA barcodes, simplifying the demultiplexing process. Background: RNA sequencing (RNA-seq) is a next-generation sequencing technique that is used to detect and analyze RNA molecules to understand how a cell works. Compared to older techniques, it is faster, more reliable, and more cost-effecti...

A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain

JianlingL@tla.arizona.edu — Thu, 10 Feb 2022 08:34:05 GMT

This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker. Background: Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic, inflammatory, and tonic pain conditions, low voltage-activated (LVA) T-type calcium channels are implicated as pain mechanisms and potential drug targets. In this technology, the inventors propose the use of a novel pan T-type calcium cha...

Copter-Based Configurable UAV

JianlingL@tla.arizona.edu — Fri, 04 Feb 2022 07:40:20 GMT

This technology is an unmanned aerial vehicle (UAV) consisting of multiple, interconnected quadcopters, which can fly in custom formations to optimize the control of the vehicle and recover from partial failures. The design allows for on-the-fly reconfiguration of the UAV, enabling robust operation in adverse weather conditions and changing shape to meet physical constraints. Furthermore, this new UAV benefits from redundant power, generated by multiple integrated quadcopters, to advance the resilience of aerial operations against failure and to improve the safety recovery capabilities of unma...

Direct Capture and Smartphone Quantification of Airborne SARS-CoV-2 on a Paper Microfluidic Chip

JianlingL@tla.arizona.edu — Wed, 19 Jan 2022 14:46:24 GMT

This is a rapid, handheld smartphone-based paper microfluidic assay that is capable of directly detecting SARS-CoV-2 in small droplets from the air, without the need for an air sampler or a long collection time. The infected droplets are collected on a paper microfluidic chip, which then has antibody-conjugated submicron fluorescent particle suspension added, with the antibody binding to the SARS antigens and aggregation. A smartphone-based fluorescent microscope is then used to quantify the extent of the particle aggregation to determine the presence of SARS-CoV-2. This method can be applied ...

Variable-Pressure Head-Out Plethysmography Chamber with Data Acquisition and Analysis Software

JianlingL@tla.arizona.edu — Wed, 19 Jan 2022 14:42:11 GMT

Animal studies have always been a large part of scientific and medical discoveries both for the animals being studied and for eventual human application. Plethysmography, studying the changes in the volume of a body or organ, is a critical part of those studies. Here specifically is the study of respiration endpoints in mice and rats given different environmental conditions including the introduction of aerosolized medication. Typically, there are two ways mice and rats have been studied: conscious or unconscious. Administering anesthesia is tricky and it does not accurately reflect the consci...

Algae Raceway Integrated Design

JianlingL@tla.arizona.edu — Wed, 19 Jan 2022 14:37:01 GMT

Algae Raceway Integrated Design (ARID) is a patented University of Arizona technology designed to maximize the production of algal biomass for fuel, feed, food, pharmaceuticals and bio-plastics. The ARID system incorporates numerous design innovations that allows for maximal algae production in low capital expense (CAPEX), low operating expense (OPEX) open pond system, that is in agricultural deployable units. Background: ARID can be utilized to produce algae biomass for animal feed, then transition into the production of algal biomass for producing Bio-diesel and Bio-jet fuel ...

Vip3-Resistant Helicoverpa Zea

JianlingL@tla.arizona.edu — Wed, 19 Jan 2022 14:33:35 GMT

This technology is a genetically diverse strain of corn earworm that has been selected over multi-generations to be resistant to Vip3 (a Bt protein produced by transgenic crops). It is a tool used for screening/selecting candidate proteins to determine if they overcome resistance. Background: A rapidly expanding global population, coupled with limited agricultural land, is driving farmers and industry to develop sustainable and productive methods of for feeding an estimated 9 billion people by 2050. Farmers are turning to biopesticides to prevent pest damage in a more ecologically friendly ma...

Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)

JianlingL@tla.arizona.edu — Wed, 19 Jan 2022 14:20:06 GMT

This invention describes the use of physachenolide C for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Physachenolide C is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with demonstrated 4-10x potency. Additionally, these compounds could also sensitize apoptosis in response to synthetic polynucleotides, which are thought to mimic anti-viral responses by activating toll-like receptor signaling. Backgrou...

Miniature Multispectral Fluorescence Imaging and Cell Collection Probe for Longitudinal In Vivo Tumor Characterization and Growth Assessment in Animal Models of Cancer

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 13:22:55 GMT

This technology is a miniature endoscopic probe that can conduct fluorescence imaging at multiple different wavelengths and collect cell samples, all encapsulated in a single probe. Because of the design of the probe, it does not require withdrawal and reinsertion to change filters or devices. It is particularly useful in examination and assessment of cancerous tumors in small living animals. The probe is also designed such that it could be implemented through the working channel of standard gastroscopes for human patients. Background: This invention is primarily designed to help impro...

Disposable Partial Vertebrate Animal Cage Divider

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:50:11 GMT

This technology is a unique animal welfare product that mimics burrow-like structures, increases engagement, and reduces aggression. The innovation was designed at a University of Arizona laboratory for group-housed mice. Background: Current caging technologies remain expensive and inadequate to provide vertebrate lab animals with separation from others. Aggression leads to problems including loss of animals, equipment damage, and testing delays. Additionally, failure to engage mice can skew laboratory data. Research done by the inventors shows that cage dividers t...

Tunable Fluorescent Indolizine Tetracycles

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:44:11 GMT

This technology is tunable fluorescent probes that are able to span the colors of the rainbow. The main benefit of this technology is that it can be prepared in only one or two steps; as opposed to the five to seven steps it would normally take. Not only is this technology quicker, but the cost of goods is also more reasonable and compares very favorably to similar products currently on the market. Background: Fluorescent dyes are very useful in many applications. Some of the most common industries include bioimaging and cell research. Currently, there are a few types of dyes on the market in...

Inhibition of SGK1 via a Synthetic Protein-Protein Interaction Inhibitory Peptide

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:41:42 GMT

This technology is a peptide that binds serum glucocorticoid kinase 1 (SGK1) to prevent binding to glucocorticoid-inducible leucine zipper protein (GILZ). The interaction between GILZ-SGK1 protects SGK1 from degradation, and the peptide developed prevents this interaction allowing for SGK1 degradation and decreased SGK1-mediated cardiac hypertrophy, cardiac fibrosis, and subsequent pathology. Background: Hypertrophic cardiomyopathy (HCM), or enlarged heart, is a rare but dangerous disease that can cause many cardiac health concerns including atrial fibrillation, blood clots, stroke, hea...

Apparatus for Active Tissue Scaffold Stretching in Cell Culture Conditions

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:39:56 GMT

This invention is a means to apply controlled dynamic forces on a macroscale tissue scaffold along a period of cell-culture conditions that can range from minutes to weeks. This apparatus uses a mechanically compliant substrate, which can be made from various materials, that supports the attached tissue scaffold. The apparatus also contains a holder to attach the tissue scaffold and an actuator with controlled motion that stretches and compresses the tissues. Background: The use of porous 3D scaffolds provides a suitable environment for the generation of tissues and organs, allowi...

Smart Box for Health Logistics

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:35:13 GMT

This invention provides a smart container for storing of biological samples that have been collected at one site and that are being sent to another site for analysis. The containers provide a number of functional benefits, including the ability to preprocess the sample, with the preprocessing intimately tied to the transportation step and the particular sample processing facility. In this manner, sample integrity may be maintained, and the sample may be automatically tailored to the receiving facility. This preprocessing can help decrease the overall processing time, increasing sample fi...

Method and System for Biological Information Pattern Storage and Readout

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:32:01 GMT

This invention is a biological information pattern (BIP) array to encode digital information into a biomolecular medium, like DNA, to store a high density of data. It also includes a label-free readout system to retrieve said information. Background: With a growing need for a tremendous amount of data storage there is a new demand for the use of synthetic nucleic acid, such as DNA and RNA, which has the capability of storing an excessive capacity of data in a small space. However, the storage of information on nucleic acid is rendered useless without a means to first store data in the nuclei...

Integrated Device for Self-Collecting and Automated Pre-Processing of Biological Fluids for Multiple Analyses

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:27:38 GMT

This invention is an integrated device where blood is collected from a skin prick and automatically transferred to prepared tubes containing reagent. The sample tubes come prepared with a specific reagent so pre-processing begins immediately and continues during transportation to the laboratory. The device incorporates several steps of biological fluid collection and storage into a single, compact device that can be operated by a healthcare professional or layman. Background: In the aftermath of a large scale nuclear event like a weapon or power plant incident in a densely populated ...

Apparatus for Reconfiguration of Components in a Micro-Physiological System

JianlingL@tla.arizona.edu — Tue, 18 Jan 2022 09:22:50 GMT

The invention is a novel apparatus utilizing modular assembly for the development of co-culture, monitoring, and study of functional interactions between different types of biological material under various environmental conditions. The buckle clamp stage-like apparatus mimics a microfluidic based system. Background: 3D in vitro models are important for studying the functional interactions of the human microbial ecosystems on human tissue. This requires a device that has various components and flexibility to accommodate specific operating conditions and experimentation. In vitro micr...

Small Molecule Mixed Agonist/Antagonist for Opioid Receptors for Anti-Addiction and/or Pain Therapy

JianlingL@tla.arizona.edu — Tue, 04 Jan 2022 12:48:36 GMT

This invention provides compositions and method of pain treatment using a mixture of an opioid receptor agonist in combination with an adrenoreceptor modulator compound. The opioid receptor agonist may be a clinically-used drug, and the adrenoreceptor modulator compound is a novel small molecule. Proof-of-concept testing in animals has shown analgesic effect without reward behavior. Background: Opioids continue to be widely used for pain treatment. However, constant opioid treatment is accompanied with serious undesirable effects including drowsiness and mental clouding, naus...

Surface-Modified Electrospray Needles for Mass Spectrometry

JianlingL@tla.arizona.edu — Wed, 15 Dec 2021 16:14:45 GMT

With this invention, electrospray needles used in mass spectrometry are coated to prevent sticking and clogging of analytes, resulting in improved mass detection sensitivity and consistency of analysis. The coating comprises an organic material covalently bonded to an interior surface of the electrospray needle. The coating is electrically non-conductive and non-ionizable. Background: Mass spectrometry (MS) analyses are used in many applications, including in the development of pharmaceuticals, detection of proteins, viruses, or biomarkers in blood, and trace gas analysis. In MS, ...

SmartPrint Polymer Material and Design for the Connection of Separate Optical Chips

JianlingL@tla.arizona.edu — Mon, 13 Dec 2021 09:12:03 GMT

This technology is a further development of interconnect polymer waveguides for photonics packaging and integration. Here, a flexible optical substrate is attached and aligned to individual photonic chip components to form an optical waveguide. The waveguide comprises a refractive index contrast (RIC) polymer directly patterned using a photolithography process. The new advance is an optical interconnect for connecting two separate photonic integrated circuit chips (chip-to-chip) as well as coupling. The refractive index contrast (RIC) polymers are suited to a wide variety of ...

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action

JianlingL@tla.arizona.edu — Mon, 06 Dec 2021 14:03:32 GMT

This invention describes an inhibitor of eIF4A, which is a validated cancer drug target. The inventors describe a novel mechanism by which this inhibitor works. Background: Oncogenic, or cancer-causing pathways have long been challenging drug targets, especially for complex cancers. One protein complex called eIF4F is key to select oncogenic pathways and drives the progression of some cancers. The eIF4F complex contributes to many of the hallmarks of cancer, such as sustained proliferative signaling, evasion of growth suppression, resistance to programmed cell death, replicative immortal...

Sensor Array for Biomarker Degradation Measurement

JianlingL@tla.arizona.edu — Thu, 02 Dec 2021 13:56:02 GMT

This invention is an electronic sensor that is modified with a recognition element. This element is modified so it may be used to capture specific molecules from non-invasive biological fluids. These fluids include sweat, saliva, and tears. These biomarkers will react to enzymes which can be used in new products to provide quantitative information related to health and well-being of patients. Background: Wearable biochemical sensors are increasing in use due to their ability to personalize medicine and continuously monitor human health. Therefore, significant research and funding has be...

Photocatalytic Alpha Arylation of Carbonyls

JianlingL@tla.arizona.edu — Fri, 19 Nov 2021 13:25:58 GMT

This invention is a method for the synthesis of alpha arylation of inexpensive, unactivated carbonyl compounds with high yields at room temperature using any photocatalyst (PC) under visible light from blue to red. Background: Functionalization of the C-H bond has evolved as a fundamental principle that underpins both academic and industrial importance in conceptualization and actualization of challenging organic transformations. This ubiquitous but relatively inert bond, if converted to more valuable C-C bond, can greatly accelerate the construction of a wide variety of compounds. This...

Artificial Neural Network Based Sleep Disordered Breathing Screening

JianlingL@tla.arizona.edu — Thu, 18 Nov 2021 11:10:08 GMT

Early detection of sleep disorders. Artificial Neural Network Based Sleep Disordered Breathing Screening.

NYTimes Complete Twitter Activity Network

JianlingL@tla.arizona.edu — Thu, 18 Nov 2021 09:38:55 GMT

NYTimes Complete Twitter Activity Network artwork for NFT

Mashable Complete Twitter Activity Network

JianlingL@tla.arizona.edu — Thu, 18 Nov 2021 09:38:10 GMT

Mashable Complete Twitter Activity Network artwork for NFT

Ego Network Growth for Washington Post Twitter Account

JianlingL@tla.arizona.edu — Thu, 18 Nov 2021 09:37:28 GMT

Ego Network Growth for Washington Post Twitter Account artwork for NFT

Ego Network Growth for BBC News

JianlingL@tla.arizona.edu — Thu, 18 Nov 2021 09:36:41 GMT

Data Science artwork for NFT Ego Network Growth for BBC News

BBC News Complete Twitter Activity Network

JianlingL@tla.arizona.edu — Thu, 18 Nov 2021 09:35:43 GMT

BBC News Complete Twitter Activity Network artwork for NFT.

Novel Antibiotic Drug Combination Including an Anti-Inflammatory Metabolite

JianlingL@tla.arizona.edu — Fri, 12 Nov 2021 14:58:37 GMT

This technology involves a combination of a metabolite, 3-hydroxyanthanilic acid (3HAA) with a compound that alters cellular iron homeostasis (e.g. an iron chelator or an iron supplement) that produces synergistic antibiotic interaction. 3HAA sensitizes bacteria to changes in iron availability (both increasing iron media content through supplementation or chelation of iron). Iron is an important element that is necessary for many critical processes in biological systems, including both eukaryotic cells and bacteria. Iron chelators act by binding iron, making it easier for cells and ...

Green-Enhancer Glasses

JianlingL@tla.arizona.edu — Mon, 08 Nov 2021 08:12:00 GMT

This invention is an optical filter which blocks out blue light and only allows green to pass through, increasing the relative amount of green light that passes through. This filter can be used on prescription and non-prescription glasses, as well as on coverings for lamps and light bulbs. Green light in the morning can rehabilitate the circadian system of aging adults leading to a healthier lifestyle. Background: Research into how exposure to various types of light affects the human body has increased recently. The result of studies has led to the conclusion that exposure to green ...

Melanopsin Blocker

JianlingL@tla.arizona.edu — Mon, 08 Nov 2021 08:09:56 GMT

This invention describes an optical filter that can be used in the production of glasses that block wavelengths of light harmful to circadian rhythms and sleep. Background: The great importance of maintaining a healthy circadian rhythm and getting good sleep continues to be firmly supported by researchers, and more healthy sleep is known to produce better health outcomes compared to those who consistently get poor sleep. Currently, the market standard glasses do not protect the wearers from an increasing threat: bad sleep caused by wavelengths of light from 455-495nm (known as blue, or circad...

Circadian Rhythm Restoring Blue Blockers

JianlingL@tla.arizona.edu — Thu, 04 Nov 2021 11:11:37 GMT

This technology is for glasses that are to be worn at night to block harmful blue light from artificial light sources. Specifically, these glasses block wavelengths associated with circadian-active light, which causes melatonin suppression. This intervention restores the endogenous rhythms of users and leads to better sleep patterns. Background: With the prevalence of mobile phones, televisions, and other screens, humans are exposed to a great deal of blue light at night. This exposure leads to the suppression of melatonin, the hormone associated with sleep. This in turn affects the huma...

Blue-Enhancer Glasses

JianlingL@tla.arizona.edu — Thu, 04 Nov 2021 11:08:26 GMT

Because of the huge increase in the amount of blue light consumed by the average individual due to myriad factors including society’s dependence on phones, tablets, and computers, blue light blocking glasses are becoming commonplace. Not only do blue light suppressing glasses decrease some of the stress on an individuals’ eyes, but the decrease in blue light staves off another side effect of blue light consumption: a decrease in melatonin production. This invention performs the opposite function, increasing levels of blue light in the morning thereby staving off melatonin...

Pink Blue Blockers

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 17:08:27 GMT

This invention uses pink lenses as an efficient way to block blue light while appealing to younger users and those who have a difficult time wearing the more visually cumbersome orange or red lenses. The use of blue light blocking glasses have recently become more popular for the general public because an increasing number of individuals spend a majority of their day looking at screens. The most effective lenses at blocking blue light—red and orange lenses—are difficult to wear and are not aesthetically appealing to younger users. Background: Currently, most blue light b...

Interferometric System with Deep Learning Algorithm to Process Two Interferograms

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 16:54:07 GMT

This invention is an interferometric system that captures two interferograms and utilizes a deep learning algorithm to process them. This invention enables the measurement of surface roughness and surface shape using the interferometric system and neural network to process the data. The deep learning portion of the system is in a compact form, allowing for on-machine measurements and a suitable attachment to the interferometric system. Background: The application of high precision optical elements is vast, from smart-phone camera lenses and telescopes to optical fibers and much more. With an ...

Control of Probe Beam Duration in Single Wavelength Monitoring of Hologram Diffraction Efficiency

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 16:32:19 GMT

This technology is a novel technique for monitoring the diffraction efficiency of Volume Holographic Elements (VHOEs) in real time. The technique works by using a shutter or chopper to periodically block one of the exposing beams during the fabrication and measuring the power of the diffracted beam using a power meter. This technique has the potential for a higher accuracy calculation of the diffraction efficiency of VHOEs at a greater simplicity. Background: Volume Holographic Elements (VHOEs) have many applications ranging from display systems, medical devices, and solar energy systems...

Overlapping Apertures Diffractive Optical Lens

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 16:10:34 GMT

This invention describes a diffractive optical lens that utilizes overlapping apertures for higher resolution images than conventional methods. The inventors have created a lens design, method of manufacturing, and an imaging instrument to utilize the lens that is based on overlapping apertures where a single coherent light illumination is used, and multiple images of the object are measured simultaneously, which can be used to construct a higher resolution image of the object. This has the potential to be superior in function and resolution in image capturing compared to the current...

Super Resolution Lens Free Microscopy

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 15:18:45 GMT

This invention describes a design for a lens free microscope system that can achieve resolution significantly better than current technologies. The technology involves the use of a nanostructured mask to encode high resolution information about the object that would normally be lost due to diffraction. Background: Lens free microscopes are advantageous in several ways including cost-effective hardware, compact and lightweight form factor, and high space-bandwidth product. Current lens free microscopy methods have limitations on resolution, as they have diffraction limits of one-half wavelengt...

Rapid In-Situ Metrology of a Heliostat Field Using Starlight

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 14:23:09 GMT

This technology is a means of rapidly measuring the optical properties of each heliostat in a heliostat field using starlight. It is ideal for use with heliostats that can have their shape actively changed to maximize their light concentration effectiveness as they track the sun over the course of the day. Background: Heliostats are devices that track the sun over the course of a day, reflecting the sunlight to a stationary target. Large arrays of heliostats, or “heliostat fields,” can be used to concentrate and focus light on one location such as a spot at the top of a tower. The...

Heralded-Multiplexed High-Efficiency Cascaded Source of Dual-Rail Polarization-Entangled Photon Pairs using Spontaneous Parametric Down Conversion

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 13:52:16 GMT

This technology is a high-efficiency, high-fidelity method of generating pairs of polarization-entangled photonic qubits. The use of a cascaded source that performs a linear-optical entanglement swap between two spontaneous parametric down conversion (SPDC) sources, to generate a heralded photonic entangled state that has a higher fidelity compared to a free-running SPDC source. Background: Quantum bits, or qubits, are basic units of quantum information that can be used to store or transmit information just like the classical bit used in traditional computing. They are the fundamental co...

Non-Gaussian Photonic State Engineering with the Quantum Frequency Processor

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 13:29:11 GMT

This technology is a means of generating non-Gaussian quantum states in light for use in quantum computing. Non-Gaussian quantum states are a subset of quantum states that enable operations that would not be possible with Gaussian states in quantum computers. As a result, they bring a lot of potential value to quantum computing. However, non-Gaussian states are also typically challenging to produce, so they have not historically been used. This technology solves this problem, creating a means of putting light into non-Gaussian states in a reliable and scalable manner that can be used as a fun...

Birefringent Coating to Remove Polarization Dependent Phase Shift

JianlingL@tla.arizona.edu — Wed, 03 Nov 2021 13:27:01 GMT

This technology is a method designed to remove unwanted phase shifts from optical instruments to improve their performance. The method involves the manufacture and application of a layer, or multiple layers, of birefringent materials (materials with two distinct refractive indices) such that the unwanted phase shift is removed from the optical instrument. Background: Optical interference filters have been around and known for a century, and these filters have been effectively exploited technologically for at least several decades. Additionally, birefringent materials have been, and conti...

Decision Support Logic for Pharmacogenomics

JianlingL@tla.arizona.edu — Tue, 02 Nov 2021 15:25:28 GMT

This technology is a database of publicly available guidelines used in conjunction with medication recommendation algorithms. The technology is a clinical intervention support tool based upon Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. It leverages genomic information and accepted guidelines to deliver recommendations customized to an individual patient. Background: Pharmacogenomics is improving the way that patients can be treated by implementing the use of a patient’s individual genetics to predict how their body is likely to respond to therapeutics. This te...

Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides

JianlingL@tla.arizona.edu — Mon, 25 Oct 2021 09:38:22 GMT

Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport within the particle in order to avoid energy dissipation during exciton transfer, making it possible to achieve an ultrasensitive platform to sense β emitters in biological systems. The scintillating MOFs mesoporous nanostructures are com...

Stereospecific Synthesis of Rhamnolipids and their Sugar Analogues from Sustainable Sources by Chemical and Chemoenzymatic Pathway

JianlingL@tla.arizona.edu — Wed, 06 Oct 2021 12:31:51 GMT

This technology is a method of synthesizing enantiomerically pure rhamnolipids without the need for a chromatographic separation, such synthesis using enzymatic processing. The method may be used to create compounds with multiple, specific chiral centers. Background: Rhamnolipids are a type of chemical notable particularly for their surfactant properties. Unlike most traditional surfactants (such as soaps and detergents), rhamnolipids can be created through an environmentally friendly process, and the resultant chemical is generally less harmful than traditional s...

Rapid-Integrations for Conjunction Assessment (RICA)

JianlingL@tla.arizona.edu — Thu, 30 Sep 2021 14:50:58 GMT

Rapid-Integrations for Conjunction Assessment (RICA) is a tool for efficiently and accurately predicting close approaches between space objects close to or in orbit of Earth, for use in planning launch and placement of satellites in Earth orbit. Background: Space around Earth is becoming progressively more congested, especially in the Low Earth Orbit band. According to NASA, there are approximately 23,000 pieces of space junk larger than a softball orbiting Earth, and there are over 100 million pieces a millimeter or larger. These pieces of junk are moving at high speed and can severely...

Covid-19 Time of Intubation Mortality Evaluation (C-TIME)

JianlingL@tla.arizona.edu — Thu, 30 Sep 2021 14:44:50 GMT

This invention describes software that uses a scoring system for calculating the probable mortality of patients with COVID-19 pneumonia at the time they require mechanical ventilation. Background: Worldwide there have been over 208 million cases of severe acute respiratory coronavirus 2 (SARS-CoV-2) and over 4.37 million of these cases resulted in death of the patient. In the United States alone there have been nearly 37 million cases of SARS-CoV-2. Although, as of August 2021, 51% of the population has been vaccinated against SARS-CoV-2, it is still imperative that treatments be available be...

9A7 Monoclonal Ab

JianlingL@tla.arizona.edu — Thu, 30 Sep 2021 08:33:19 GMT

This invention is an IgG2b monoclonal antibody that targets vitamin D receptor (VDR) and is made and derived from Lewis rats with partially purified chicken intestinal vitamin D receptor. Background: 1,25-dihydroxyvitamin D3 receptor (VDR) is implicated in a range of inflammatory, dermatological, osteoporosis, cancers and autoimmune conditions. The 9A7 monoclonal antibody was first cloned in the 1980s and has significant interest in being licensed for commercial purposes. The inventors have noted that the IgG2b 9A7 antibody is made in Lewis rats with partially purified chicken intestina...

Novel High Refractive Index and Abbie Value Polymers for Advanced Lower Cost Optical Eyewear

JianlingL@tla.arizona.edu — Wed, 15 Sep 2021 11:17:20 GMT

Copolymerization of chalcogenide halides with widely available unsaturated monomers is used to create advanced polymer materials for consumer plastic optics, consumer eye wear, and smart phone plastic optics. Background: Sulfenyl chlorides are a widely known but largely ignored class of sulfur compounds that are highly reactive toward nucleophiles and electrophilic unsaturated compounds. Sulfenyl chlorides are closely related to organosulfur thiol and mercaptan molecules were the R-S-H bond is replaced via chlorination reactions to form the R-S-Cl, which is constitutes the sulfeny...

Selective Melanotropin 4 Ligands for Neurodegenerative Diseases

JianlingL@tla.arizona.edu — Thu, 02 Sep 2021 09:13:23 GMT

This technology is the development of ligands that selectively bind to the Melanocortin 3 Receptor (MC3R) and Melanocortin 4 Receptor (MC4R) and modulate receptor activity for neurodegenerative diseases. The melanocortin receptor ligand is bound to an MC3R and/or MC4R selective moiety, which allows the complex to cross the blood brain barrier. The ligand-moiety complex has improved selectivity to MC3R and/or MC4R and anti-inflammation function. Background: MC3R and MC4R are under-targeted in treatments for neurodegenerative diseases. In addition, existing ligand analogues have low selectivit...

Combinations for the Treatment of Neurodegeneration

JianlingL@tla.arizona.edu — Thu, 02 Sep 2021 08:48:06 GMT

Researchers at the University of Arizona have researched new formulations and combinations of compounds for the treatment of Alzheimer’s disease. Developing a novel computational system allowed the inventors to identify several therapeutic targets of single cell type and whole bulk tissue that contribute to Alzheimer's disease. These therapeutic targets could be used individually or in combination with other drugs for the treatment of Alzheimer’s. Background: At least 50 million people are living with Alzheimer’s disease or other dementia disorders. Hardly any drugs for ...

Small Mine Activities Reporting Tool (SMART): A Mobile App to Improve Compliance Reporting and Track Outcomes

JianlingL@tla.arizona.edu — Wed, 01 Sep 2021 14:24:52 GMT

This technology is a smartphone-based software platform to implement the mining health and safety reporting requirements overseen by the Mine Safety and Health Administration (MSHA). Small mining operators often face challenges implementing the requirements, and this software helps demystify the process. Developed with input from MSHA, state grants programs, and mine operators, the app helps ensure the proper tracking and reporting of hours worked, activity commencement and closure, and record-keeping for workplace accidents and injuries. It supports capture and storage of photos and videos as...

Device for Improved Hydration During Exercise

JianlingL@tla.arizona.edu — Wed, 04 Aug 2021 11:18:32 GMT

This technology encompasses the design for a device that can easily deliver water or other sources of hydration from a bottle, directly to a user during exercise without the use of a traditional hydration bladder. Background: Those engaging in active exercise such as bike riding, hiking, or rock climbing often desire a way in which they can hydrate from a water or other drink source while still exercising. The common solution for many is a bladder-style hydration pack, with a water reservoir (usually contained in a backpack) with a tube for access while exercising. Camelbak and other outdoor ...

Apparatus for Adjustable Spectral Resolution, Self-Calibration, and Self-Stabilization of Smartphone Spectrometer

JianlingL@tla.arizona.edu — Mon, 26 Jul 2021 12:30:54 GMT

This technology allows for the ability to adjust spectral resolution and spectral range of a smartphone spectrometer through the use of a rotating grating wheel. It enables self-calibration and self-stabilization by coupling a source into the designed optical system. Sources are the built-in smartphone flash, other sources built into the smartphone, or another source included in the optical system design. Background: Spectroscopy is a scientific measurement technique to study matter through its interaction with different components of the electromagnetic spectrum or through interactions...

Method to Rescue Light Sensitivity in Retinas after Photoreceptor Degeneration

JianlingL@tla.arizona.edu — Mon, 26 Jul 2021 12:11:24 GMT

This invention describes a method by which light sensitivity in the retina can be restored using gold nanoparticles after the photoreceptors have been degraded or damaged. Background: Traditional treatment for visual impairment can differ based on the cause of the impairment, but often includes eyeglasses, contact lenses, Lasik surgery, or simple quality of life (QOL) aids such as service dogs or canes. In many cases, visual impairment or blindness is not fixed or repaired, but mitigated as long as possible. This has left a large demand for some technology or therapeutic that can actually hel...

Ambient Dried Aerogels based on Alkyl Sulfide Bridged Polysilsesquioxanes

JianlingL@tla.arizona.edu — Tue, 13 Jul 2021 23:00:43 GMT

Aerogel is a low-density solid material that is produced by removing the liquid component from a conventional gel. Ambient dried aerogels utilize calculated levels of temperature and pressure using certain chemicals to remove the liquids from the aerogel. This technology is a method of preparation of low density, porous aerogels without the use of supercritical temperatures and pressures from bridged polysilsesquioxane alcogels with dialkylsulfide, dialkyldisulfide, and dialkylpolysulfide bridging groups. These gels are prepared from bis (trialkoxysilyl) monomers which are dried by ...

Applied Resuscitation Education & Specialized Training (AREST)

JianlingL@tla.arizona.edu — Thu, 08 Jul 2021 14:16:33 GMT

Our researchers have created a training outline called: Applied Resuscitation Education & Specialized Training (AREST) programs, which have been designed to teach first responders how to care for patients with life- threatening medical problems. This innovative approach differentiates AREST from traditional programs by offering both online and in-person modalities and cost-effective pricing. Background: Cardiopulmonary resuscitation, more commonly known as CPR, is a life-saving technique that helps maintain blood flow to the brain and heart in an emergency situation. In Western-dev...

Analytic System for Automated Prognostic Determination of Disease Risk from High-Resolution, Non-Invasive, Contrast-Free Retinal Images

JianlingL@tla.arizona.edu — Thu, 08 Jul 2021 13:18:22 GMT

This invention describes a platform by which age-related macular degeneration (AMD) prognostic determinations can be made through high-resolution, non-invasive, contrast-free retinal images and diagnostic software. Background: Currently, the leading method of diagnosis or prognosis determination for not only age-related macular degeneration (AMD), but most diseases, is through conventional chemical and physician methods. Even with certain elements of this process being automated, this can cause for inefficiency and variation in the process. It is proposed to develop a new analytic syste...

PHOENIX: No-Code Development of Mobile Patient Companion Apps

JianlingL@tla.arizona.edu — Thu, 08 Jul 2021 13:15:18 GMT

This technology is a development platform designed to facilitate the rapid creation of custom smartphone applets for self-management of a patient’s health. Using a simple drag-and-drop interface, individuals with no programming skills can easily and efficiently create custom interactive tutorials. Background: Patient Self-Management (PSM) apps are used to guide patients through self-management of their own medical conditions or general health and well-being via engaging content. For example, PSM apps may provide tracking, goal setting, or educational materials to help patients outside o...

A Microbiome Sparing, Organism-Specific Therapy for C. difficile Infection

JianlingL@tla.arizona.edu — Wed, 07 Jul 2021 08:28:30 GMT

University of Arizona researchers have developed a water-soluble nanocarrier that is non-toxic to both human tissue and to bacteria. The carrier can complex with oligonucleotides that can bind to bacterial mRNA, preventing translation and inhibiting various bacterial functions. Background: The carrier can complex with translation-inhibiting modified oligonucleotides of such length that specific species of bacteria can be targeted. This technology not only allows for species-specific killing of bacteria, but unlike all current antibiotics, it allows for inhibiting bacterial virulence factors ...

Removal of Uranium using Rhamnolipid Biosurfactants and Ion Flotation

JianlingL@tla.arizona.edu — Tue, 06 Jul 2021 11:07:37 GMT

This technology is a solution to the problem of increasing amounts of naturally occurring uranium in groundwater. This ion flotation technique is a simple, cost-effective, green method to extract rare earth elements from aqueous solutions in an effort to keep the public and environment safe and compliant with EPA standards.Background:In the western half of the United States especially, there are approximately 4,200 legacy mining sites that have been used in the past to mine for uranium. However, between 1980 and 2000 the price for uranium dropped and many of these mining sites were left abando...

Optical Materials for Printing Glass Optics

JianlingL@tla.arizona.edu — Thu, 01 Jul 2021 09:41:21 GMT

This technology uses a liquid, solvent-free, silica precursor, and two-photon 3D printing process for high-precision glass micro-optics. Background: Inorganic glasses are widely used in industry due to their excellent optical, chemical, and thermal properties. Conventional grinding and polishing methods are the current standard for fabricating spherical, aspherical, and flat surfaces. However, this technique is slow, incapable of affording freeform surfaces, and not suitable for fabrication of glass micro-optics. This technique will overcome the shortcomings of conventional techniques t...

ORACLE - A PHM Test & Validation Platform for Anomaly Detection in Biotic (e.g., Vital Sign) or Abiotic Sensor Data

JianlingL@tla.arizona.edu — Thu, 01 Jul 2021 09:37:20 GMT

This invention is a prognostics and health management (PHM) test and validation platform named ORACLE. The ORACLE emulates the occurrence of environmental changes and generates a log file to allow for training and subsequent deep learning-based anomaly detection frameworks for monitoring space habitat health. ORACLE uses multi-layer feedforward networks or other deep learning approaches to detect anomalies. The ultimate goal is to use the measured “biometric” changes in each crew member as a supplementary indicator to detect degradation in the space habitat environment and associat...

Hub and Spoke Mushrooms

JianlingL@tla.arizona.edu — Tue, 29 Jun 2021 11:18:04 GMT

This invention is a controlled mushroom harvesting system that has applications in restaurants, markets, and cafeterias. Background: The mushroom cultivation process is unique and specialty mushrooms can be extremely delicate and hard to transport. The main environmental factors that contribute to optimal fruiting conditions are temperature, relative humidity, carbon dioxide, and lighting. This fruiting chamber is a controlled-environment capable of managing all of these variables. This point-of-harvest system brings fresh ingredients that normally could not have been provided to the cus...

Design of Intelligent Aeroponic Microgravity & Earth Nutrient Delivery System (I-AMENDS) for Bioregenerative Space Life Support and Earth Applications

JianlingL@tla.arizona.edu — Tue, 29 Jun 2021 10:54:38 GMT

This technology allows for the growth of plants in zero-gravity or microgravity environments. The invention solves the problem of directing water and nutrients to plant roots by incorporating liquid and nutrient emitters that allow for the efficient and effective flow of the water into the system. The design, which is suitable for small growth chambers and large-scale crop production, then uses air emitters to move the water and nutrients in the appropriate direction(s). Background: Since the first flight to the moon, and perhaps before, mankind has been possessed by the idea of space travel ...

Language Learning Platform for Translators and Interpreters

JianlingL@tla.arizona.edu — Wed, 16 Jun 2021 15:12:48 GMT

This technology is a platform for language learning that combines videos and text translations to help train professional translators and interpreters. Unlike many existing solutions, this platform goes beyond teaching the meaning of isolated words, and focuses on the overall, more subtle meaning of what is being conveyed. Background: Language learning tools have become progressively more valuable in modern times. Globalization and the rise of the internet have turned bilingualism and multilingualism into a highly valued skill. Furthermore, interpreters are especially important to ensure tha...

Blood Biomarker for the Diagnosis and Treatment of Chronic Inflammation in the Brain in the Days and Weeks after Stroke

JianlingL@tla.arizona.edu — Wed, 16 Jun 2021 14:14:47 GMT

This invention comprises a method of identifying chronic inflammation in the day(s), weeks, or months after a stroke by measuring matrix metalloproteinase-12 (MMP-12) in a patient to determine whether therapeutic intervention is required to help immune cells process lipid debris after stroke to reduce secondary neurodegeneration. MMP-12 is a protein biomarker associated with neurological inflammatory diseases and has been found here to be correlated to chronic inflammation in the brain following stroke. Therapeutic efficacy may also be assessed using MMP-12 assays. Background: According to Ce...

Methods and Apparatus for High-Resolution Tissue Microscopy

JianlingL@tla.arizona.edu — Tue, 15 Jun 2021 20:03:19 GMT

This technology is a new type of microscope that allows for rapid diagnosis of skin lesions on a person’s body without the need for invasive procedures. This technology further advances noninvasive skin microscopy techniques, providing a solution that increases diagnostic accuracy and reduces time to diagnose. It can be used on its own or in conjunction with other state of the art non-invasive skin microscopy technology. Background: Skin cancer is the most common form of cancer. Over 20% of all Americans will have skin cancer at some point in their life, and more than two people...

A New Mouse Strain (Zip14flox/flox (Slc39a14flox/flox)

JianlingL@tla.arizona.edu — Tue, 15 Jun 2021 11:24:55 GMT

University of Arizona researchers have generated a new Zip14flox/flox mouse strain. The strain can be used to generate Zip14 knockout in a tissue-specific manner and is useful to examine tissue-specific function of Zip14. Applications: Functional analysis of Zip14

Grasshopper Harvester

JianlingL@tla.arizona.edu — Mon, 14 Jun 2021 13:50:41 GMT

Killing two birds with one stone is a common way to describe one solution that takes care of two problems. This invention kills three. The destruction of grassland and crops via locusts and other grasshoppers; The ever-increasing need for protein creation and human consumption; and Farmer’s need to feed their livestock with protein-rich food. This is a self-driving grasshopper collector which, especially for organic farms not using pesticides to keep grasshoppers and locust swarms at bay, helps to keep a high crop yield without using pesticides. Furthermore, the ability to collect...

Device for Collecting Volumetric Measurements of Objects with Complex Shapes

JianlingL@tla.arizona.edu — Mon, 14 Jun 2021 13:37:19 GMT

This technology is a device that facilitates accurate and precise volume measurements of solid objects. Originally created for the purpose of measuring the total volume of a sample of plant matter, it is ideal for measuring the volume of any solid material with complex shapes or many holes and gaps. Background: In agriculture, it is valuable to have methods of measuring the yield of crops in a reliable and repeatable way; this can facilitate precision agriculture practices, where the ideal distribution of nutrients or irrigation are used to maximize crop yields. However, to reliably maximize ...

"Stick and Peel" Probe Properties of Perovskite Material Properties for Manufacturing Scale-Up and Quality Control

JianlingL@tla.arizona.edu — Fri, 11 Jun 2021 14:35:17 GMT

A “stick and peel” removable electrochemical probe is used for solvent-free characterization of semiconductor films or optoelectronic devices. The invention may be used to analyze electronic materials such as a metal halide perovskite, an organic semiconductor, a nanocrystalline (quantum dot) thin film, metal oxides, a material blend or a device stack. The method may be used to analyze numerous characteristics, such as numbers of defects or defect density, stability, surface composition, band gap, physical structure, electroactivity, band bending, migration/diffusion pr...

Targeting CD44-Moesin Interactions with Small Molecules for Alzheimer’s Disease

JianlingL@tla.arizona.edu — Wed, 09 Jun 2021 11:51:02 GMT

This technology is a small molecule compound that could serve as a potential therapeutic for Alzheimer’s Disease (AD). The compound binds to Moesin, a protein that is associated with AD. It targets interactions between Moesin and CD44, an antigen that also has been shown to be a biomarker for AD. Targeting CD44 and Moesin interactions has proved to be a potential effective therapy for AD. Background: Alzheimer’s Disease is the sixth leading cause of death in the United States. Currently over 6 million adults in the United States have been diagnosed with AD, with the number project...

Novel Peptides Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment

JianlingL@tla.arizona.edu — Wed, 09 Jun 2021 11:21:46 GMT

Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable compounds may be further developed for use as non-opioid pain relief, social anxiety, anti-addiction, or post-traumatic stress disorder. Background: Opioid drugs like morphine and Oxycontin® are considered to be the gold standard for mana...

Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazine Reagents

JianlingL@tla.arizona.edu — Tue, 08 Jun 2021 08:53:06 GMT

The invention includes triazines for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc. Application of UV light at neutral pH releases diazonium species, which can be used in a wide variety of applications, including protein tagging or modification. This chemistry may be used to create libraries of designed conjugates that may be stored safely for long periods of time. Background: Triazines and methods of producing diazonium species from said triazines using ultr...

Small Diffusive in Situ Soil Gas Probes and Sampling System for Online Soil Gas Measurements

JianlingL@tla.arizona.edu — Wed, 02 Jun 2021 14:25:08 GMT

This invention is a small soil gas sampling probe that is connected to an individual recirculating loop that includes a micropump and a multiport selective flow-through valve. This design allows for gas to be recirculated and flow through the recirculating loop until analysis. Analysis of the soil gas sample is performed by small sensors using an online sample equilibration, transfer, and measurement system to determine the concentrations of gas at high spatial and temporal resolution without sampling artifacts. Background: The composition of gas in soil is a powerful indicator of various imp...

Rapid Diagnosis of Microbial Pathogens in Aquatic Species

JianlingL@tla.arizona.edu — Tue, 25 May 2021 08:06:14 GMT

This technology is a rapid colorimetric assay to detect and diagnose diseases in various aquaculture species by utilizing a loop-mediated isothermal amplification (LAMP) and reverse-transcription loop-mediated isothermal amplification-based (RT-LAMP) assay. This product allows sensitive detection of <100 viral, bacterial, and fungal pathogen genomes per reaction without the need for a DNA/RNA purification step. This technology can be used in conjunction with conventional quantitative PCR and quantitative reverse transcription PCR without the need for DNA extraction from the sample. Backgro...

Method and Therapeutic use of PIGN and Other Genes or Gene Products that PIGN Interacts with for Prognosis and Treatment of Hematological Neoplasias

JianlingL@tla.arizona.edu — Mon, 24 May 2021 15:35:00 GMT

This invention provides a method for determining the risk for the development or progression of a hematologic neoplasia in patients by analyzing the level of a phosphatidylinositol glycan anchor biosynthesis protein (PIGN) and providing a guideline for appropriate treatment or preventive measures. Background: Myelodysplastic syndromes (MDS) are classes of hematologic cancers that often progress into acute myeloid leukemia (AML). These conditions are especially troubling, as there are typically no symptoms before advanced progression. Additionally, there are currently no commonplace ...

Therapeutic Nanoparticles for Renal Disease

JianlingL@tla.arizona.edu — Tue, 18 May 2021 12:02:06 GMT

University of Arizona researchers have developed a technology that uses biodegradable, polymeric nanoparticles to specifically deliver drugs to the kidney, thereby bypassing off target/organ effects. For example, drugs such as formoterol, a beta 2 adrenergic agonist, can be used to treat acute and chronic renal disease. Encapsulation of these drugs into nanoparticles targets them to the kidney and prevents cardiovascular side effects that come from traditional drugs of these type. Background: Renal disease can be treated with a range of drugs classified as beta 2 adrenergic agonists; ho...

Stem Cell Fusion Model of Carcinogenesis

JianlingL@tla.arizona.edu — Tue, 18 May 2021 11:59:13 GMT

This technology is a method for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell. Background: Cancer has been difficult to treat because of tissue heterogeneity and gene instability. Recently, discoveries centered around stem cells and their potential effectiveness in treating cancer have opened up new opportunities. This technology intends to expand the current use of stem cells and cancer treatments. Applications:...

Allosteric NAMPT Activators for Metabolic and Neurological Disorders

JianlingL@tla.arizona.edu — Tue, 18 May 2021 11:49:19 GMT

This invention relates to a novel method of increasing the catalytic activity of the enzyme, nicotinamide phosphoribosyltransferase (NAMPT), which in turn increases the production of nicotinamide mononucleotide (NMN) that is converted to nicotinamide adenine dinucleotide (NAD). This process to increase supply of NAD in the body is accomplished using small-molecule allosteric NAMPT activators. NAD supplementation has been shown to have benefits towards diseases of aging, metabolic disorders, and stroke. Background: Nicotinamide adenine dinucleotide (NAD) is a coenzyme that is central to m...

THALASSA (Software Tool for High-Accuracy, Long-Term Analyses for Space Situational Awareness)

JianlingL@tla.arizona.edu — Thu, 13 May 2021 10:30:51 GMT

THALASSA (Software Tool for High-Accuracy, Long-Term Analyses for Space Situational Awareness) is a numerical code for software that is to be used to calculate trajectories of uncontrolled objects in near-Earth space from initial position and velocity. This software also poses a non-averaged method of calculating Earth satellite orbit propagations. The software efficiently handles strong lunar gravitational perturbations through a trajectory splitting algorithm. Background: Due to increased access to space attributed to technological advancements, Resident Space Objects (RSOs) are expect...

Systems and Methods for Identity Authentication using the Keystroke Dynamics of a Single Interaction Session

JianlingL@tla.arizona.edu — Thu, 13 May 2021 10:27:32 GMT

This technology is a method of detecting an online impostor using keystroke dynamics without requiring prior collection of behavioral data from the true user. Background: Keystroke dynamics is an area of behavioral biometrics that attempts to identify or authenticate a user by collecting data about how a user types, such as the length of time between key presses and the duration a key is depressed. This information can then be used to detect changes in typing behavior, which may suggest the person typing is an impostor or bot. This technique has seen widespread adoption in recent years and ad...

2-Aryl-Pyridylazoles for the Treatment of Solid Tumors such as Pancreatic Cancer

JianlingL@tla.arizona.edu — Tue, 11 May 2021 14:59:21 GMT

University of Arizona researchers have identified two potent small molecules that target a common mutation found in pancreatic cancer cells with high specificity and induce cell death. These compounds are genotype specific for the DPC4 mutation associated with cancer phenotypes and, compared to available treatments, are significantly more potent and have less harmful side effects in normal cells. The anti-tumor agents have been tested in three pancreatic cell lines and have demonstrated a 16- fold selectivity difference against DPC4 deficient cells. Background: Pancreatic cancer is the fourt...

Photocatalytic Alpha Arylation of Carbonyl at Room Temperature to Simplify and Reduce Costs of Manufacturing Pharmaceuticals

JianlingL@tla.arizona.edu — Fri, 07 May 2021 15:59:33 GMT

This invention is a new synthesis route for producing an alpha-aryl substituted cyclic ketone from a cyclic ketone compound using an aryl halide and an acridinium ion photocatalyst. The method of the invention is particularly useful in producing an alpha-aryl substituted cyclic ketone from an un-activated cyclic ketone compound. This is vast improvement to the synthesis of building blocks to many different fine chemicals and pharmaceuticals. This allows companies to perform the alpha arylation at room temperature, in the absence of expensive and toxic metals, and with commonly available ...

Returning Jaguars

JianlingL@tla.arizona.edu — Wed, 05 May 2021 14:18:41 GMT

Scientists at the UA Conservation Genetics Lab created the documentary “Returning Jaguars” for viewers to learn about the Southern Arizona jaguar as well as topics such as regional land management and conservation that impacts the jaguars. The documentary describes methods of jaguar detection motion cameras, scat sampling, and hair sampling. The camera tracking method for jaguars and ocelots uses cameras deployed at 140 sites over 16 mountain ranges, and the success of this method makes it a model for other research programs tracking large mammals. Given the large number of ca...

Earthlight

JianlingL@tla.arizona.edu — Wed, 05 May 2021 14:18:00 GMT

"Earthlight" is an Emmy Award-winning documentary that examines and chronicles the technological advancements behind designing sustainable food sources for use in space missions and here on Earth. "Earthlight" explores the innovations accomplished at The University of Arizona to solve the problems of growing sustainable food in harsh environments. It explains not only how the technologies are important for the establishment of a moon or Mars base and how they will fit in the context of future space missions, but also how the technologies can help secure the long-term susta...

Ultrafast Optical Switches and Transistors

JianlingL@tla.arizona.edu — Thu, 29 Apr 2021 16:25:25 GMT

The inventors have demonstrated attosecond switching speed in a light field-induced phase transition of a dielectric system. This switching occurs under ambient conditions and provides for data encoding by synthesized laser pulses. This technology may be used for ultrafast optical-based switches and data transfer with petahertz speed and optical transistors. Hui et al, ScienceAdvances, 22Feb2023, Vol 9, Issue 8 https://doi.org/10.1126/sciadv.adf1015 Background: Modern electronics are founded on switching the electrical signal by radio frequency electromagnetic f...

All-Optical Laser Field Sampling

JianlingL@tla.arizona.edu — Thu, 29 Apr 2021 16:09:50 GMT

This technology is a system and method configured for measurement of an electronic delay response of a dielectric system triggered by a strong driving optical field of sub-femto-second pulses. The produced electronic response demonstrates all-optical light field sampling operating with sub femto / attosecond resolution. This invention demonstrates the on-demand quantum electron motion control in solid-state with the use of synthesized waveforms. Background: Attosecond pulses generation and spectroscopic measurements in gases and solids open a new window into the study of electronic driv...

Deconvolution of Charge Detection-Mass Spectrometry Data

JianlingL@tla.arizona.edu — Wed, 28 Apr 2021 10:44:22 GMT

This mass spectrometry analysis software and method extends the UniDec Bayesian deconvolution algorithm for application to two-dimensional charge detection-mass data. A 2D plot of m/z versus charge is created from raw data. Smoothing and background subtraction may be used, and deconvolution is applied to remove uncertainty in the charge and the m/z dimension to smooth neighboring charge and mass states. Background: Mass spectrometry (MS) and intact mass analysis are increasingly common in academic and industry research. This has created a demand for more robust approac...

Novel Mechanism Anti-Fungal with High Specificity

JianlingL@tla.arizona.edu — Mon, 26 Apr 2021 15:06:52 GMT

University of Arizona researchers have discovered a novel approach for treating fungal or yeast infections using a previously unstudied GPCR-like protein, which is integral to the regulation of cell growth in yeast cells. This protein and metabolic pathway is absent in higher-order animals, which provides a novel pathway for drugs to stop the growth of deadly fungal pathogens, such as drug resistant Candida glabrata. This technology may also provide a route to improved control of yeast growth in manufacturing. Background: This invention builds on a previous UArizona discovery of a novel cell ...

What Are Near-Earth Objects

JianlingL@tla.arizona.edu — Mon, 19 Apr 2021 12:22:58 GMT

This production looks at near-Earth objects - what are they, how are they formed, where they come from, and where they are going. This was developed form OSIRIS-REx mission to explain concepts to the public.

Photo-Magnetically Actuated Deformable Mirror

JianlingL@tla.arizona.edu — Thu, 15 Apr 2021 15:39:54 GMT

This technology is a flexible deformable mirror and wireless actuator using a combination of light and magnetic components, to enable large and small scale deformations. Background: Deformable mirrors (DMs) are special mirrors designed to be deformed to provide optical aberration correction in high performance optical systems. These mirrors are particularly useful in astronomy and retinal imaging where image quality needs to be maximized at high magnifications, as well as in control and shaping of laser beams. Traditional DMs use an array of actuators behind the mirror which deform the mirro...

Elimination of Aflatoxin via Aflatoxin-Degrading Enzyme Expression in Crops

JianlingL@tla.arizona.edu — Thu, 15 Apr 2021 13:01:36 GMT

This technology involves the expression of an aflatoxin-degrading enzyme in maize kernels. The enzyme was engineered to target the endoplasmic reticulum (ER) and become expressed using an embryo-specific promoter in the transgenic maize. It can be used in combination with an RNAi suppression method, HIGS, to protect maize during pre-harvest conditions. Background: It is estimated that 25% of the world’s crops are contaminated with a mycotoxin, a toxin produced by fungal sources. Aflatoxins are one class of mycotoxins that have two particularly toxic strains that are often found in maize...

Controlled Transfer of Endohyphal Symbionts among Fungal Strains

JianlingL@tla.arizona.edu — Thu, 15 Apr 2021 11:36:27 GMT

University of Arizona researchers discovered that diverse endophytic fungi were found to harbor endohyphal bacteria (EHB), which live within apparently healthy, viable fungal cells. Differences in suites of EHB between closely related fungal endophytes suggest horizontal transfer of these symbionts in nature. This relationship appears facultative for both partners, as bacteria can grow freely under laboratory conditions and the researchers successfully cured fungi of their EHB. Background: Plant-associated fungi provide important ecosystem services as pathogens, mycorrhizae, endophytes...

Method, System and Devices for Defining Respiratory Status

JianlingL@tla.arizona.edu — Tue, 13 Apr 2021 13:51:01 GMT

This invention is a system comprising FDA-approved MC10 BioStamp wearable sensors to gauge respiratory health in patients. The sensors are applied directly to the skin and can be used to produce gyroscopic data, including information around muscle activation and sleep. The data can be cross-referenced with observations from a motion capture system. Motion of the thorax was able to be measured, which could potentially lead to a viable method for measuring lung performance. The system allows for storage, analysis, and telemetry of data. Data is entered int...

Photo-Curable Liquid Acrylate and Methacrylate Modified Silsesquioxane Oligomers with Built In Radical Initiators for Additive Manufacturing

JianlingL@tla.arizona.edu — Tue, 13 Apr 2021 13:44:36 GMT

This invention is a new photochemically curable resin with photo initiators for radical curing. This invention allows for faster curing rates using high and controlled concentrations of initiators. The invention also improves upon currently available resins, as this invention reduces the chances of resin chemical leaching and solves plasticization issues. It provides for a more durable and safer product. Background: The current composition of the photo-curable resin used in practice today are composed of mixtures of acrylate or methacrylate monomers and comonomers which have mu...

3D Printing Using Tholins or Other Extraterrestrial Polymers

JianlingL@tla.arizona.edu — Tue, 13 Apr 2021 13:42:27 GMT

This technology will utilize non-earthbound resources as a polymer for use in 3D printing materials. This technology utilizes a polymer derived from Tholins. Background: It is costly and impractical to transport large amounts of material for construction and repair during space exploration and travel. 3D printing utilizing materials found in space has the potential to reduce this transportation need. Another problem is the reliance on finite, earthbound resources for 3D printing materials. This new invention will allow 3D printing system to utilize extraterrestrial resources in...

3D Printing of Glass Structures Using Laser Patterning of Precondensed, Liquid Silica and Organically Modified Silica Polymers

JianlingL@tla.arizona.edu — Tue, 13 Apr 2021 13:32:11 GMT

This technology allows for 3D printers to print optical structures that have a glassy texture. The technology takes liquid polymer silica and transforms it into the desired optical structure, with minimal shrinkage. Background: The 3D printer market has had an increasing demand and growth over the past few years. With the wide variety that the market offers, it allows for a wide variety of potential uses in every industry there has been an increasing demand for its applications. Though with all of the possibilities there has been a push for testing out new materials to print and use...

Discovery of Pyrazolopyridine Analogs as Broad-Spectrum Antivirals against Non-Polio Enteroviruses including EV-D68, EVA71, and CVB3

JianlingL@tla.arizona.edu — Fri, 09 Apr 2021 11:16:53 GMT

This invention reports the discovery and development of pyrazolopyridine inhibitors that have been shown to be effective in cell culture against multiple strains of non-polio enteroviruses including: EV-D68, EVA71, and CVB3. There are currently no antivirals or vaccines for non-polio enteroviruses, and the health consequences of infection for some can be severe. Background: Non-polio enteroviruses are types of viruses that are very common, and more than 100 types exist. Non-polio enteroviruses cause about 10 to 15 million infections in the United States each year. Tens of thousands of pe...

Arizona Public Media News Department Photo

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:44:19 GMT

This is a photo by Christopher Conover of United States Representatives David Schweikert and Martha McSally, Homeland Security Seretary Kirstjen Nielsen, and federal Border Patrol agents at the border fence in Nogales, AZ.

Arizona Illustrated Episode #107643: Terrol Dew Johnson

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:43:47 GMT

Arizona Public Media presents a segment on Terrol Dew Johnson, a complex figure living in multiple intersecting realities. He is perhaps most well known for his grassroots community activism with the group Tohono O’odham Community Action, which he helped fund over 20 years ago. Johnson is also an accomplished artist with work in the permanent collections of Museum of Modern Art in New York, the Heard, and Smithsonian. This story catches up with Johnson in October 2016 after returning from Standing Rock as he prepares for a new exhibition with architecture and design firm, Arand...

Asteroids vs Comets

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:43:12 GMT

This production is from OSIRIS-Rex and presents a 321Science video about the differences and similarities between asteroids and comets. The video explores the ways in which scientists are discovering that asteroids may be more alike than different.

What is the Yarkovsky Effect

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:42:41 GMT

This is from the OSIRIS-Rex and presents a 321Science video about how sunlight can affect the orbits of small asteroids. The video explores how the Yarkovsky effect occurs and how it can change the orbit of asteroids, changing near misses to impacts or vice versa.

What Are Asteroids Made Of

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:42:10 GMT

This is a production from OSIRIS-Rex that discusses the basic materials of asteroids. The video explores how scientists observe asteroids and use laboratory analysis of meteorites to find out what asteroids are made of.

How Do We Find Asteroids

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:41:41 GMT

This production presents information on how scientists discover asteroids. This is from the series related to the OSIRIS-Rex mission to explain certain concepts to the public.

Asteroids Fact vs Fiction

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:40:48 GMT

This production is part of the series developed from the OSIRIS-Rex mission to explain mission concepts to the public. This specific production discusses asteroids, what they are and what is science fiction and fact.

Behind the Scenes at Antiques Roadshow in Tucson: The Navajo Blanket

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:40:18 GMT

This production discusses one of the appraisals at the Antiques Roadshow in Tucson. Of all of the hundreds of appraisals done, the one that seared into the memory of fans and staff alike was the Navajo blanket.

Mt. Lemmon Science Tour app

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:39:44 GMT

This app is an audio guide for the drive up the Catalina Highway to Mt. Lemmon in Tucson, AZ. It connects the users to the amazing science and natural history of the region, underscoring how research from the University of Arizona has expanded the understanding of the area.

Level One Trauma

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:39:07 GMT

This is a revealing production that takes the audience inside the University of Arizona Medical Center’s level one trauma center. The documentary shows the struggles that first responders, doctors, nurses, and other specialists undertake as they try to save lives.

Barrios and Barriers: The Tucson Civil Rights Era

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:38:39 GMT

This documentary explores the Tucson Civil rights struggle during the mid-twentieth century. It tells stories of discrimination through personal experiences and triumphs drawn from the lives of several Tucson residents.

Community Interactive: Stories From The Border

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:38:07 GMT

This production is a live, interactive event featuring a panel of respected and accomplished journalists from Mexico and the United States.

Arizona Illustrated: Sanctuary

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:37:21 GMT

This is a segment of the Arizona Public Media’s original television production, Arizona Illustrated, entitled "Sanctuary." The segment provides local efforts to provide protection and assistance to refugees and immigrants. The story of one immigrant claiming political sanctuary in a local church is incorporated into this segment. Background: Arizona Illustrated engages and educates southern Arizona viewers with thought-provoking and diverse topics that reflect the unique community in which those residents live. Viewers are engaged with powerful storytelling and photography. A...

The Desert Speaks

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:36:52 GMT

This series gives a voice to the desert experience through global perspective. Background: Dr. David Yetman represents a special mixture of knowledge, experience, and passion to educate the public in order to demonstrate the inherent value hidden in arid regions. Noted academic, prolific author, and storied presenter, he relishes the opportunity to meaningfully engage with his subject field. A transplanted resident of the American Southwest, for decades this "desert rat" has studied and closely interacted with the Sonoran people, history, and natural environment. Through The Desert ...

Passing On

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:36:31 GMT

This documentary discusses end of life care and planning. It is intended to educate viewers on the importance of planning for end of life.

Southwestern Gems: Our Desert National Parks

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:36:01 GMT

This Emmy-winning production showcases the top national parks, monuments, preserves, and historic sites within the four major North American deserts. The high-definition footage brings to life the features and distinct character of each of the desert areas. Throughout the production, experts, researchers, and rangers from national parks guides viewers through the biology, geology, and research that inspired the protection and preservation of the natural treasures.

Michael Drake Interviews

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:35:35 GMT

This invention stems from a series of videos, produced by Arizona Public Media (AZPM) detailing the space exploration work done by the University of Arizona, and specifically, Michael Drake. This work includes the OSIRIS-Rex sample return mission to asteroid Bennu and the Phoenix Mars Missions that investigated the existence of ice on Mars. The invention is raw footage of interviews done with Michael Drake, previously the Director of the University of Arizona’s Lunar and Planetary Laboratory. The invention has the potential to allow licensees to use the footage as an inclusion to the pr...

Arizona Illustrated: Stealing Woman-Ochre

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:35:04 GMT

This is Episode 114897 of Arizona Public Media’s original newsmagazine program Arizona Illustrated.      Background: This program examines the theft of Willem de Kooning’s painting Woman-Ochre from the University of Arizona Museum of Art in 1985.

Arizona Illustrated: Opening Safer

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:34:30 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Opening Safer."      Background: With the reopening of the campus nearing, the University of Arizona’s plan to Test, Trace and Treat is critical to making it safe. Testing and treating are well underway, but what about tracing? We approached those involved in UArizona’s tracing program to find out.

Arizona Illustrated: The Full Nelson

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:33:49 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "The Full Nelson."      Background: Life has thrown her a few curve balls. She is a mother, author and performer... Adiba Nelson is a force of nature.

Wave Front Sensor based on Fourier Filtering

JianlingL@tla.arizona.edu — Wed, 07 Apr 2021 15:31:10 GMT

This invention describes a sensor that can measure the wave front of an incoming electromagnetic wave. The sensor has application in semiconductor and precision optics metrology, ophthalmic diagnostic imaging, remote sensing and laser beam characterization. In addition, wave front sensor is a key component of adaptive optics system which is used in astronomy, vision science, microscopy, laser and microelectronics manufacturing and free space optical communications. Background: A wavefront sensor is a device for measuring the aberrations of an optical wavefront. The wave front of the electroma...

Genetic Markers For Resistance Against Acute Hepatopancreatic Necrosis Disease (AHPND) In Shrimp

JianlingL@tla.arizona.edu — Fri, 02 Apr 2021 13:44:50 GMT

This invention describes a genetic line resistant to Acute Hepatopancreatic Necrosis Disease (AHPND). A gene expression analyses was conducted to measure the relative expression of genes in two populations of shrimp (susceptible and resistant lines). Differentially expressed genes have been identified as markers for resistance and/or susceptibility to AHPND in shrimp. Background: Acute Hepatopancreatic Necrosis Disease (AHPND) refers to a lethal disease found in marine shrimp that has caused increasingly greater amounts of mortalities in shrimp aquaculture throughout Asia and the Americas. It...

Guayule Particle Board

JianlingL@tla.arizona.edu — Wed, 31 Mar 2021 15:43:08 GMT

This invention is a particle-board comprising a fiber component including guayule bagasse and an adhesive composition including a mixture of a modified guayule resin and soy protein. The resultant composite has mechanical properties comparable to particle boards formed from soy protein adhesives alone while also having enhanced wet shear strength, and hence improved water repellent features, as compared with particle-boards formed from soy protein adhesives alone. The use of guayule also provides for enhanced anti-termite and/or enhanced anti-insect properties as compared with parti...

Modified Guayule Resins and Resin/Soy Protein Blends for Adhesives

JianlingL@tla.arizona.edu — Wed, 31 Mar 2021 15:42:31 GMT

This technology is a guayule resin-based adhesive that provides superior water resistance over existing formaldehyde-free wood adhesives. A blend of modified guayule resin with soy protein forms a natural adhesive with improved water resistance over existing soy protein adhesives. Background: Guayule, a plant that grows in the Southwest United States and Mexico, is a promising source of hypoallergenic natural latex rubber, requiring little water to cultivate. However, extracting latex from Guayule requires processing the entire plant, leaving most of the plant’s biomass as a bypro...

Tigress Diversifying C Virtualizer

JianlingL@tla.arizona.edu — Wed, 31 Mar 2021 08:50:54 GMT

The Tigress Diversifying C Virtualizer supports against various novel defenses, static and dynamic alike, against well-known de-virtualization attacks. Furthermore, Tigress contains a collection of traditional obfuscating transformations such as control-flow flattening, opaque predicate insertion, and function merging and splitting. As a result, the generated interpreters are stealthier, more diverse, and more resilient to attacks. Advantages: Tigress supports all of the C99 language, including gcc extensions The transformed code can be easily examined, which is useful in a pedagogical ...

Sugar-Based Low Molecular Weight Hydrogels from Alkyl Glycolipids

JianlingL@tla.arizona.edu — Fri, 26 Mar 2021 12:56:56 GMT

University of Arizona researchers have created sugar-based low molecular weight hydrogels that spontaneously self-assemble through weak, noncovalent intermolecular interactions. These gels are thixotropic, biocompatible, and biodegradable. Despite being held together through non-covalent interactions, these hydrogels exhibit greater mechanical strength than other non-cross-linked hydrogels. These hydrogels are biocompatible and biodegradable since the materials are based on sugars. The other advantages of these low molecular weight hydrogels include resistance to acidic and salty environments,...

Monolithic Membrane Optomechanical Sensor

JianlingL@tla.arizona.edu — Wed, 24 Mar 2021 11:01:07 GMT

This invention is a monolithic membrane optomechanical sensor, capable of achieving micro-g sensitivity for acceleration sensing in a monolithic, chip-scale platform. It consists of two membranes with differential stiffness on a single silicon chip. Due to the differential stiffness, both the membranes react differently to the actuating force. This displacement between the two membranes can be monitored with high precision using the cavity formed between the two reflecting surfaces. This kind of sensing can apply to accelerometry, vibrometry, shock and acoustic sensing. Background:Micro...

Instrumentation and Methods for Optical Metrology of Heliostats

JianlingL@tla.arizona.edu — Wed, 24 Mar 2021 10:52:21 GMT

This technology solves the need to recognize and track the shape of adjustable and customizable heliostats by using a receiver fly eye lens, through which a metrology camera can quickly capture the beams of light coming through the array of apertures and determine their centroids and angles, therefore determining the shape and direction of the heliostat. The heliostat is then adjusted to maximize the system’s reflective efficiency and increasing the overall efficiency of the plant itself. Background: Concentrated solar power (CSP) is a method of generating power by using heliostats to d...

PLpro Inhibitors Against SARS-CoV-2

JianlingL@tla.arizona.edu — Tue, 23 Mar 2021 13:04:02 GMT

There are two cysteine proteases that are encoded by SARS-CoV-2, the main protease (Mpro) and the papain-like protease (PLpro). Both of these proteases have been shown to be essential in viral replication and are validated antiviral drug targets. PLpro cleaves the viral SARS-CoV-2 polyprotein at three sites. In addition, it modulates host immune response by cleaving the ubiquitin and ISG modifications from host proteins. This technology identified several novel compounds that are effective in inhibiting SARS-CoV-2 PLpro. Because of its role in viral replication and immune modulating, inhibitio...

Mood Altering Device, System and Method

JianlingL@tla.arizona.edu — Mon, 22 Mar 2021 09:33:08 GMT

This invention is a small device, suitable for home or personal use, that exposes the user to green light and other sensory stimuli, for the purposes of elevating their mood. Background: Mood disorders and negative moods are pervasive in the modern world. The World Health Organization estimates that over a quarter of a million people worldwide suffer from depression. In the same vein, an estimated 7.1% of all US adults experienced at least one major depressive episode in 2017. And these numbers are limited to the clinical definition of depression; other people may experience shorter-lived dep...

Systems, Methods and Devices for Light Exposure via Visual Displays

JianlingL@tla.arizona.edu — Mon, 22 Mar 2021 09:22:50 GMT

This technology is a system and device that modifies visual displays such as computer screens, televisions, and smartphone screens to emit light at wavelengths that provide therapeutic effects. Background: As electronic devices with display screens are becoming increasingly common, the amount of time spent in front of screens is correspondingly growing. A UK survey found that the respondents spent, on average, 3 hours and 23 minutes of screen time per day, adding up to 50 days over a year. Screen time is particularly high among teens and tweens; in 2019, teens spent 7 hours and 22 minutes of ...

Personalized Dietary Recommendations guided by Continuous Glucose Monitoring

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:20:09 GMT

This invention is a method for integrating glucose monitoring data with a mobile diet tracker to automate personalized dietary recommendations with the goal of improving health and preventing disease related to or caused by the dysregulation of glucose metabolism, including but not limited to diabetes. Background: Diabetes is a leading cause of death worldwide. According to the International Diabetes Federation (IDF) Diabetes Atlas, 8th edition, there are currently 425 million people living with diabetes. More than 90% of these people are living with type 2 diabetes (T2D). There are another 3...

Medication Education, Decision Support, Reminding, and Monitoring System (MEDSReM) Mobile Application (App)

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:19:20 GMT

The United States and many other western countries have aging populations. With age comes wisdom, but also a myriad health problems. Of those health problems, hypertension is one of the leading causes of heart complications and death. Approximately 30 million people in the United States currently take blood pressure medication to mitigate the risks of hypertension. Blood pressure medication staves off the long term effects of high blood pressure over years. However, individuals must take this medication regularly and in specified windows. If a time window is missed, individuals may have too mu...

Arizona Public Media Original Television Program Segment: Arizona Illustrated Episode 49077 "Stories from the Boneyard"

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:17:18 GMT

This is an episode of Arizona Public Media's original newsmagazine program Arizona Illustrated entitled “Stories From the Boneyard.”  Background: One of the most recognizable landmarks in Tucson, “the Boneyard,” is home to over 400 aircraft from the 309th Aerospace Maintenance Regeneration Group. These aircraft are stored on a 2,600 acre plot in southeast Tucson, adjacent to Davis-Monthan Air Force base. This production tells the stories of these aircraft.

Road to War Web Application

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:14:24 GMT

This invention is software designed for the US Army to effectively train Non-Commissioned Officers (NCOs) in-person or remotely in a variety of situations. The application leverages an AI-based reactive unit structure and operational environment to teach leadership skills on a virtual unit comprised of reactive virtual soldier bots. Background: The US Army must provide a variety of trainings to all soldiers, including trainings in leadership and decision making. This application can help in virtual delivery of these trainings, as well as help to provide a clear system to evaluate and compare...

Education Technology to Assist Learners

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:13:35 GMT

Education disparities are a hallmark of conversation between politicians, school board members, teachers, and parents across the nation. 2020 has brought on a new perspective, students involved in mandatory online education without being able to consistently be online creates an obvious new disparity. This technology seeks to solve the problem and resolve the disparity between those who have technology and internet access and those who do not. This project seeks to solve three major problems: (1) Provide students who have no computer access; (2) Provide students who have computers but no...

RATTLER!

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:12:46 GMT

This special looks at the relationship between humans and rattlesnakes. It takes viewers into the desert to observe scientists researching rattlesnake behavior and to an annual rattlesnake roundup sponsored by the Jaycees. The program explores how human fears may be endangering the rattlesnake population and what is being done to better understand this perceived menace.

The Desert Speaks #1002

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:11:56 GMT

This Emmy award-winning series focuses on desert regions around the world. This is more than a nature documentary. This series presents stories about the people, culture, plants, animals, and geological features encountered on travel adventures in deserts near and far away. David Yetman, a research scientist at the University of Arizona’s Southwest Center, hosts this show as he uses boats, bikes, and burros to take viewers from Bolivia to Baja California. He brings a great deal of enthusiasm, energy, and knowledge to the series.

Divine Mission: San Xavier del Bac

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:11:27 GMT

This special follows the renovation of the only standing Mexican Baroque church in the United States, San Xavier del Bac. The renovation is led by a skilled team of international conservators. It also features the history of the church and its people as well as an in-depth look at the skills and techniques used in art and historical preservation.

Domain Transferable Neural Network Architecture for Fact Verification

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:10:56 GMT

The problem this invention solves is that of spurious patterns or invalid results from software neural networks tasked to use natural language programming for fact verification in news or articles. This approach increases the accuracy of fact verification. Neural architectures with improved transfer between domains enables re-use of trained models, saving protracted re-training periods. This enables ranking of content, such as news articles, based on their factuality. Background: We’ve witnessed growing political upheaval in the last few years, thanks to the prolifer...

In the Americas with David Yetman, Season 8

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:10:20 GMT

This is an HDTV series that takes an in depth look at the heartland of Arizona, New Mexico, Sonora, and Chihuahua, and its peripheries. For each country, an in depth look at the histories of the natives and immigrants, islanders and mainlanders, rural folk and city-dwellers. This show undertakes a new approach to travel and adventure with a decided bias in favor of the western continents and islands. Background: The Southwest Center seeks to define, illuminate, and present through research, teaching, and publishing the character of the Greater Southwest. Each country within the Greater Southw...

In the Americas with David Yetman, Season 6

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:06:19 GMT

In the Americas with David Yetman, Season 3

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:01:42 GMT

In the Americas with David Yetman, Season 2

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:01:10 GMT

In the Americas with David Yetman, Season 1

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 10:00:38 GMT

Institutional Knowledge Map

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 09:57:45 GMT

The proposed technology uses software visualization techniques to display structured and unstructured data in an interactive geographical map. The technology incorporates machine learning and natural language processing to develop the results displayed to showcase various types of research topics. Background: Currently, within the market, there are a variety of analytical software systems that are used to assist different aspects of a business by either simplifying their work process or making a process more efficient. Within the market, there are a variety of software and cloud-based systems...

Arizona Week: Logging in When You're Locked Up - Tablets in Jail

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 09:51:48 GMT

This production discusses how men and women in the Pima County Jail are using electronic tablets, making it the only facility in the state allowing such access, which the jail says comes at no cost to the county.

Mutation Impacting Locule Number in Brassica Rapa

JianlingL@tla.arizona.edu — Thu, 18 Mar 2021 06:44:25 GMT

Brassica rapa is a plant species growing in various widely cultivated forms including the turnip (a root vegetable), Napa cabbage, bomdong, bok choy, and rapini. The oil made from the seed is sometimes also called canola or colza. The invention provides mutant Brassica plants that have increased locules and seed production relative to native wild-type plants. The primary use for these plants is to produce oil. Background: Global demographics are changing and driving the need for higher agricultural yields. Part of this changing demographic has led to consumption of higher quality food, includ...

Method, System and Devices for Generating Defined Fiber Constructs

JianlingL@tla.arizona.edu — Mon, 08 Mar 2021 07:25:10 GMT

This invention is a novel method to the improvement of nano-fiber scaffolding. The cells that make up every human, or any organism for that matter, are held together largely depending on the extra-cellular matrices within different tissues (bone, skin, tendons, blood vessels etc.). These matrices help to keep the cells in place and provide a structure upon which cells are able to proliferate and adhere correctly. Electrospinning has proven to be a way to recreate scaffolding using micro and nano fibers that also allow cells to adhere and propagate. This invention and advancement of the c...

Peptide Therapeutic for Triple Negative Breast Cancer

JianlingL@tla.arizona.edu — Mon, 15 Feb 2021 15:52:51 GMT

This invention provides compositions and methods for treating breast cancer using peptides or peptide mimics that bind to epidermal growth factor receptor (EGFR) and block transport of EGFR to cell nuclei. This mode of action results in loss of cancer cell survival and migratory capacity and induces tumor regression. This therapeutic induces cell death in wildtype EGFR-expressing cancer cells, but not normal epithelium. Efficacy experiments in a mouse model for EGFR-dependent breast cancer resulted in significant tumor regression without observable toxicity. Target disease indicatio...

Apparatus to Measure Direction, Intensity and Polarization of Electromagnetic Wave

JianlingL@tla.arizona.edu — Wed, 10 Feb 2021 11:02:04 GMT

This technology is a sensor that measures direction, intensity and polarization of an electromagnetic wave, enabling precise tracking of the position and orientation of a moving or stationary object. Background: The global demand for sensors is worth well over $100 billion. Technological advancements in various industries and the demand for increased automation correspondingly increases demand for innovation in sensors. Contact-free sensors that can measure or track the position of an object with high precision have numerous applications. In the manufacturing industry, these sensors are used...

Measuring the Electromagnetic Properties of Structures with Visible Light

JianlingL@tla.arizona.edu — Wed, 10 Feb 2021 10:38:36 GMT

Researchers at the University of Arizona have demonstrated a modeling system for measuring the Radar Cross Section (RCS) of structural models using visible wavelengths of light. This makes it possible to use very small scale models of very large objects, and accurately determine the RCS in a reasonable time frame. Background: RCS is the measure of a target's ability to reflect radar signals in the direction of the radar receiver, measured as the ratio of backscatter power per steradian (unit solid angle) in the direction of the radar (from the target) to the power density ...

Inverse Optical Design Software

JianlingL@tla.arizona.edu — Wed, 10 Feb 2021 10:33:54 GMT

The 'inverse optical design' approach is the opposite of traditional optical design. Data consist of raw detector outputs from a Shack-Hartmann wavefront sensor, and parameters in the eye model are then determined via maximum-likelihood estimation methods. This invention is related to UA07-055 in that this disclosure reveals the software code and is copyrighted. Background: Adaptive optics technology using wavefront sensors is currently making profound contributions to vision science and ophthalmology. It provides eye specialists with superior techniques for studying and correct...

Independent Household Water Purification and Electrification System Optimizing Design Software

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 11:26:36 GMT

This technology is a standalone solution that provides water purification and solar power generation to individual households in remote areas or areas with no power grid. The physical purification and power equipment is designed with software that enables the equipment to be tailored and optimized for the location it is deployed. Background: Reliable access to safe drinking water is one of the global health challenges. According to the World Health Organization, over 750 million people lack access to a basic drinking water service, and approximately 485,000 people die every year due to diseas...

Real-Time Snake Detector Utilizing TensorFlow Lite API Mobile Application

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 11:24:25 GMT

This invention is a mobile application which could be used to detect and warn in real time, the presence of snakes utilizing machine learning software. Background: With increasing commercial and residential growth in places like Florida and Australia that have a great population of snakes, this construction is causing the reptiles' natural habitat to be displaced. As they move closer to residences and public spaces, there has been an increasing amount of reported snake bites. The problem this tech solves is the uncertainty and lack of knowledge the general public has when it comes to snak...

System and Method for Streak Reduction in MRI

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 10:41:47 GMT

This technology is a new technique for Magnetic Resonance Imaging (MRI) reconstruction that reduces or eliminates streaking in radial MRI images without significant signal loss. It can be used on its own or working together with existing streak reduction techniques, such as iterative reconstruction. Background: Radial sampling (as opposed to Cartesian sampling) in MRI is particularly useful in reducing scan times and producing images resistant to artifacts caused by the subject’s motion. This makes radial sampling particularly useful in abdominal imaging, where it is difficult to keep ...

Materials Selection Criteria for Electrochemical Sensing Using Organic Electrochemical Transistor (OECT)

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 10:39:46 GMT

This technology is a new method for selecting materials when designing organic electrochemical transistors (OECTs). This method aides the design of OECT-based sensors, enabling optimization for operating power level and sensitivity. Background: OECTs are transistors useful in sensing and bioelectronics because they are simple, easy to manufacture, and miniaturizeable. They can translate the presence of various substances in a fluid into an electrical signal, and they are especially useful for detection of substances found in small quantities such as biomarkers within the sweat on someone&rsq...

Design Guideline of Floating Gate Electrolyte-Gated Transistor (FGEGT) Sensors

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 10:38:23 GMT

This technology is a method for designing floating gate electrolyte-gated transistor-based sensors, so that the sensor achieves a maximum sensitivity while maintaining a low operating voltage. Background: Electrolyte-gated transistors (EGTs) are a type of transistor particularly useful in biosensors due to their simplicity, sensitivity, low voltage needs, and compatibility with fluids. Floating gate electrolyte-gated transistors (FGEGTs), a type of EGT, have recently been proposed for sensing molecules, ions, or particles in a fluid, as they are less vulnerable to degradation caused by contac...

Printed Wearable Microfluidic Sweat Sensor Array

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 10:37:03 GMT

This invention is a wearable biosensor that is capable of sensing biomarkers of interests in sweat. This invention has the flexibility to be worn, the durability to withstand the common degradation of polymers in complex aqueous/organic environments, and the sensitivity to pick up on multiple biomarkers found in human eccrine sweat. Background: Wearable biosensors are garnering substantial interest due to their potential to provide continuous, real-time physiological information via dynamic, noninvasive measurements of biochemical markers in biofluids, such as sweat, tears, saliva and interst...

Kappa Opioid Receptor Antagonists for Sleep Disorders

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 08:59:26 GMT

Researchers at UArizona have discovered that kappa opioid receptors influence sleep in mice struggling with chronic pain. In particular they found that a kappa opioid receptor antagonist could be beneficial for improvement of sleep related to pain conditions, as well as other conditions where increased kappa opioid receptor signaling has been observed. This second portion of related conditions includes depression, generalized anxiety disorder, alcoholism, and drug addiction. Background: Disruption of sleep is a pertinent problem to patients who struggle with chronic ...

Circadian Responses to Light-Flash Exposure: Conceptualization and Data Guiding Future Directions

JianlingL@tla.arizona.edu — Thu, 04 Feb 2021 08:55:37 GMT

Though perhaps not often thought of first, the circadian system in the human body is essential to important daily and cyclical bodily functions including: hormone release, temperature control, eating habits, mood, sleep, etc. Those circadian responses in the human body are primarily triggered by light exposure. There is a body of research surrounding mammalian exposure to light pulses and the effects of those light pulses on the circadian rhythm. This technology is an addition to the body of research and shows the utility of intermittent light administration on the order of nanoseconds and mi...

Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation

JianlingL@tla.arizona.edu — Wed, 03 Feb 2021 13:44:44 GMT

This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options. Background: The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably lower side-effects. Treatments that target multiple kinds of cancers and are precise in their targeting are in high demand. The compound in this invention has the potential to treat melanoma, renal carcinoma, and/or prostate cancer patient...

Virtual Reality Simulation for Airway Management

JianlingL@tla.arizona.edu — Thu, 28 Jan 2021 11:21:43 GMT

This invention is a dual haptic-virtual reality task training system for medical students and/or professionals learning tracheal tube intubation. This technology combines the current training method and a mannequin with VR/AR and a haptic feedback and force measuring system. By creating a medical training system with a more life-like simulation, users can experience the inherent difficulties encountered in performing intubation and use the visual, tactile, and force feedback systems to improve their technique. Background: An endotracheal tube is placed when a patient is unabl...

Treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) with a Polypeptide

JianlingL@tla.arizona.edu — Wed, 20 Jan 2021 09:38:44 GMT

The SARS-CoV-2 virus binds to ACE2, a cell surface protein receptor. The ACE2 binding reduces the ability of ACE2 to break down Angiotensin-II (Ang-II). Ang-II is a potent vasoconstrictor that can increase lung injury and lung edema, increase blood pressure, and can be harmful to organ function at high concentrations. This technology administers a polypeptide through a pharmaceutically acceptable salt form to patients infected with the SARS-CoV-2 coronavirus. The polypeptide works to counteract the harmful effects of Ang-II and thus is an effective treatment for coronavirus symptoms...

Sphyingolipid-Derived Cancer Nanotherapeutics

JianlingL@tla.arizona.edu — Wed, 20 Jan 2021 09:35:50 GMT

This invention is an improvement to a commonly used drug delivery vehicle: liposomes. Liposomes, while useful for their improved pharmacokinetics, have not demonstrated significantly improved efficacy and patient survival. This may be in part due to the fact that generally only one drug can be loaded per liposome. However, this technology allows co-delivery of multiple drugs. Coupled with its sphingolipid composition, this technology has the potential to result in therapeutics that not only have improved stability and circulation time, but also greater efficacy in treating patients. It is als...

Discovery of Non-Covalent Inhibitors Targeting the SARS-CoV-2 Main Protease

JianlingL@tla.arizona.edu — Wed, 20 Jan 2021 09:00:04 GMT

This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of more antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are non-covalent inhibitors with high enzymatic inhibition and antiviral activity against SARS-CoV-2. Background: The COVID-19 pandemic caused by the SARS-CoV-2 virus has brought forth an urgent need for novel drugs and therapeutics to help fight the novel disease. Demand for an effec...

Photolithographic Method for Producing Acoustic Detectors

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 14:56:56 GMT

This technology is a new method to produce hydrophone and acoustic detectors based on the acoustoelectric effect, rather the piezoelectric effect to create an electrical signal. The manufacturing method uses photolithographic techniques, offering finer control of the design and scale of the device. In order to produce detectors or hydrophones for ultrasound imaging and therapy, it is necessary to manufacture them on a fine scale (sub-millimeter to a few microns) by means of, for example, photolithographic techniques, which permit a much smaller feature size than previous acoustoelectric hydrop...

Method and Apparatus for In-Line Photoacoustic Imaging

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 14:52:03 GMT

This technology is an optical system consisting of a right angle prism, or thin parallel plate, in conjunction with water, an index matching fluid, or some other liquid, that completely reflects acoustic waves to and from an array ultrasound transducer while being optically transparent. The geometry allows simultaneous direct illumination, with high-energy laser pulses, of the region imaged by the ultrasound transducer array. This extends the existing capabilities of an ultrasound transducer with the ability to acquire photoacoustic data. This device addresses the challenge of illuminat...

Therapeutic and Prophylactic Measures of Acute Hepatopancreatic Necrosis Disease (AHPND) in Shrimp

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:41 GMT

Acute Hepatopancreatic Necrosis Disease (AHPND) also known as Early Mortality Syndrome (EMS) is one of the most devastating diseases for shrimp farming in the last decade. Since its discovery in 2009, AHPND caused $2.56 billion dollars worth of losses in Vietnam, $11.6 billion in Thailand, and significant losses worldwide as the disease increases its geographic reach. This technology is part of the solution to the AHPND problem plaguing the shrimp market. The idea is giving the the shrimp an ability to defend against the disease by using a feed that includes a protein additive. This prot...

Genetically Engineered Recombinant Proteins for Functional Regenerative Tissue Scaffolds

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:39 GMT

This technology encompasses the development of recombinant tissue-specific proteins that are used to produce hydrogel scaffolds that mimic the structure of natural tissues and are therefore able to harness the function of the tissues. Each protein sequence is able to be precisely customized, which allows the tissues to be biocompatible and efficient in vivo. While versatile, this technology was created to produce a biopolymer scaffold that can be used for cardiovascular tissue applications. Background: Cardiovascular disease is the number one cause of death worldwide and in the United States....

Handheld, Rapid, Extremely Sensitive Assay of SARS-CoV-2 Infections

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:35 GMT

This invention is a rapid antigen test to detect the presence of SARS-CoV-2 that uses a paper microfluidic chip and a smartphone-based fluorescence microscope. Virus-specific antibody-conjugated fluorescent particles and a biological fluid sample (saliva, mouth gargle, etc.) from the patient are added onto a paper microfluidic chip, causing target antigens to flow through the chip and inducing particle to aggregate. The microfluidic chip is then analyzed using the smartphone-based fluorescence microscope, which can count the aggregated particles one-by-one and quantify the amount of virus in t...

Sensor Signal Prediction at Unreported Frequencies

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:26 GMT

The Internet of Things (IoT) systems are increasingly complex as people continually prefer more information and automation. This trend has been growing in manufacturing, home safety, and building automation. One of the major realities faced by IoT systems is an overwhelming amount of data coming from sensors. Not only that, but the cost of having all sensors constantly monitoring on all frequencies is very high. This technology is a step toward a cost-effective solution. The general idea in this invention is a framework for predicting unreported signals by estimating the correlation of those ...

Portable Deep Neural Network based Side Channel Attacks

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:19 GMT

This technology uses deep neural networks to examine the power states of a device performing cryptographic operations and determine the underlying encryption key with high accuracy across varying processor architectures. Background: Embedded systems are among devices often the most vulnerable to attacks on their security. They are often used in public or in distributed environments where it becomes a challenge to prevent physical tampering. The Internet of Things has resulted in a dramatic increase in the prevalence embedded devices, many of which process sensitive information. And the rapid ...

Lifelong Adaptive Neuronal Learning for Complete, Coverage Path Planning by an Autonomous Multi-Robot Team

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:16 GMT

This invention is an approach to neural networks solving both the human intervention problem and the power mitigation problem. Artificial Neural Tissue is a neural network with no centralized controller that allows a swarm of robots to cover a new area in near linear time. In this instance providing a solution to large spacecraft monitoring. Background: UAVs, AUVs, artificial intelligence, machine learning, and swarm intelligence are the present and future of taking care of tasks difficult or expensive for humans to perform. And, as mankind branches into new zones like space, deep...

TrustFlow

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:13 GMT

TrustFlow is a technology that enhances the security of systems based on the RISC-V architecture by protecting the integrity of sensitive data in memory. Background: Embedded systems and the Internet of Things are becoming more and more commonplace. As these devices become ubiquitous and applied to more critical applications such as medical uses and autonomous transportation, the need for security is paramount. First introduced in 2010, RISC-V is an open-sourced architecture for designing processors, with immense growth potential due to its capacity to be used by smaller companies that would...

Evaluating Hotels to Optimize Guest Sleep

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:44:08 GMT

Excluding the exigent circumstances of 2020, the United States has approximately 4.9 million hotel rooms and, at any given time, approximately 3 million of those are occupied. The increased ability of people to travel all over the United States and the world is a trend that continues to rise. While hotels provide a number of amenities for guest comfort (i.e. WIFI, flat screens, entertainment etc.) is there a way to understand how well guests sleep in a given hotel? All of the other comforts are important, but customers are usually there to sleep. Is there a way to accurately track the sleep qu...

Cyber Virtual Learning Environment (VLE) and CyberApolis

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:43:56 GMT

The Cyber Virtual Learning Environment (VLE) is a hybrid cloud-based training platform designed to deliver the infrastructure necessary to allow students to conduct performance-based assessments utilizing several interactive applications and CyberApolis virtual world. CyberApolis is an unstructured synthetic live environment designed to replicate the real internet. It provides a realistic non-scripted training environment that forces the student to synthesize and apply what they have learned. Background: Cyber security involves protecting information and systems from major cyber threat...

Andrew Weil Center for Integrative Medicine - Integrative Telehealth Network

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:43:41 GMT

Integrative health emphasizes a holistic, patient-focused approach to health care and wellness. Integrative medicine addresses a wide range of health influences, including physical, emotional, mental, social, spiritual, and environmental. This technology uses an integrative approach to medicine and provides a telehealth approach. The telehealth approach allows for the integrative healthcare to be distributed to patients via electronic information and telecommunication technologies. Background: Traditional western approaches to medicine often fall short when it comes to treating chronic illnes...

Assessment of Sleep Environment (ASE)

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:43:39 GMT

This invention is a 13-item questionnaire that assesses the degree to which an individual's environment impacts on their sleep. It measures light/dark, noise/quiet, smell, humidity, sleeping surface, safety, and other factors. Background: In spite of the relatively short history of sleep and sleep disorder research, significant progress has been made in the field over the past few decades. Recent significant discoveries include the discovery of hypocretin/orexin and its role in sustaining wakefulness. This discovery has had profound impact on the diagnosis and treatment of sleep rela...

Atmospheric Turbulence-Controlled Cryptosystems

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:43:37 GMT

This technology is a new type of cryptosystem that leverages atmospheric turbulence to protect free-space optical communication from eavesdropping. Background: Free-space optical (FSO) communication, the use of light as a communication method through the air, space, or water without the use of cables, is a promising communication method, particularly useful when traditional wires are cost-prohibitive or impractical. To improve the security of this communication method, cryptographic techniques such as quantum key distribution (QKD) or physical-layer security can be used to render FSO communic...

Highly Transmissive Infrared Polymer Micro Optical Lenses and Arrays

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:43:21 GMT

Polymeric microscale lenses, which are highly transmissive for infrared wavelengths, can be fabricated using photolithography. Arrays of lenses may be mass produced and incorporated into optical-electronic systems. Background: Conventionally, lenses for use in infrared imaging have been made from inorganic materials due to their superior optical properties at infrared wavelengths. Material cost and fabrication challenges have limited use of inorganic IR materials in optical systems or as components in integrated electronic systems. To tackle this problem, hybrid inorgani...

Virtual Cognitive Rehabilitation (VCR)

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:37:02 GMT

This invention is a phone-based application that utilizes existing technology like Android smartphones and the Oculus RIFT Virtual Reality headset system, to provide navigational tasks centered around exploitation of virtual worlds for the treatment of patients with cognitive impairments, particularly those that have experienced a traumatic brain injury. Background: Virtual reality (VR) has been expanding rapidly in the last few years, with systems drastically decreasing in price and increasing in portability with all-in-one configurations that have high accuracy and visual resolution to comp...

Picture Rosters Tool Suite

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 12:36:51 GMT

The proposed technology is a software that instructors can use to learn their students’ names. The technology can present the instructor with flashcards of their students and their information. The technology can also be used to randomize discussion within the classroom. Background: The education market is tailored to assist individuals within the education industry. With the range of education levels there are a variety of different products that are used for each level. The proposed technology offers instructors at any level to have a software that develops flashcards from t...

Automated Drone Date Pollination System

JianlingL@tla.arizona.edu — Mon, 11 Jan 2021 11:20:26 GMT

This technology is the use of a drone that uses remote sensing, image recognition, unmanned aerial system, machine learning, data analytics and industrial design to eliminate the intense labor needs in date tree farms. The system will be able to find date trees and identify fruit arms to dispense pollen from a custom-made pollen dispenser attached to the drone. The drone will also be able to locate mature flowers and differentiate the younger ones in order to get the most pollen. Background: Pollinating date trees is physically demanding and very expensive. Date trees are currently p...

Assay for Environmental Chitin Quantification

JianlingL@tla.arizona.edu — Fri, 11 Dec 2020 12:48:31 GMT

This invention is a novel method for use in conjunction with the quantification of chitin levels in environmental samples. The technology provides a method for detecting medium-sized chitin micro particles (CMPs). This information can be useful in assessing the risk of chitin exposure as well as helping in evaluating the benefits of chitin remediation in commercial and residential locations. Background: Indoor Air Quality (IAQ) refers to the detection and reduction of known allergens and air pollutants from commercial and residential buildings. PAMPS (pathogen-associated-molecular patt...

Formulations to Inhibit Hemotoxic Venoms

JianlingL@tla.arizona.edu — Thu, 03 Dec 2020 12:40:28 GMT

This invention uses the chemical element of Ruthenium compounded with other chemical substances and in conjunction with a carbon monoxide releasing molecule (CORM-2) as an anti-venom against four different venoms from the genera Bothrops, Calloselasma, Echis, and Oxyuranus. Background: According to the World Health Organization, it is estimated that around 5.4 million people are bitten by venomous snakes each year and at least 80,000 of those snake bites are lethal, with many more causing long-term health issues. Additionally, effective anti-venoms can be used to combat lizard or insect bites...

Device for Automating Scientific Model Assembly from Text, Equations, and Software

JianlingL@tla.arizona.edu — Thu, 03 Dec 2020 12:39:54 GMT

This invention is a system that can construct and curate complex representations of scientific models by integrating three different sources of information. The three sources of information being natural language descriptions and technical documentation of models, model equations, and software used to implement the models. All three sources of information require their own separate tools/software to translate the information into a single unified form. Background: Computational modeling is the use of computers to simulate and study complex systems using mathematics, physics, and compute...

Predictive Modeling of People Movement and Disease Spread on Campus under COVID and Pandemic Situations

JianlingL@tla.arizona.edu — Thu, 03 Dec 2020 12:38:29 GMT

A lack of information is perhaps the crux of every problem involving public policy. In 2020, COVID-19 emphasizes the lack of data and information with which public figures attempt to make decisions. Ideally, public policy, including policy for large institutions, would be made with a crystal ball and 100% certainty of the effects of the policy. Because this is impossible, simulations try to iterate and propagate key assumptions over time. This invention provides policy makers a novel simulation based on a student-mobility model and a disease propagation in tandem. Student mobility meaning a G...

Biomarker for Patient Stratification for Treatment of Cognitive Impairment in Patients with Vascular Contributions to Cognitive Impairment

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 14:45:56 GMT

This technology has found a serum biomarker that is efficacious in stratifying patients with vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD). This biomarker was able to indicate patients with high levels of VCID that are well suited for treatment with angiotensin peptides. Background: Worldwide, an estimated 50 million people are living with some form of dementia but much is still unknown its causes, how to properly diagnose it, and especially how to treat it. Research through clinical studies is therefore imperati...

Multiplexed Computed Tomography X-ray Imaging

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:58:36 GMT

This invention presents novel multiplexed measurement designs that improve X-ray CT imaging system’s performance. An imaging fidelity metric is employed to optimize multiplex measurement design. This considers the next generation Rectangular-Fixed-Gantry (RFG) CT system architecture containing several X-ray sources and detector arrays deployed in a fixed geometry. Such an RFG CT system architecture affords us the opportunity to explore non-standard multiplex measurement designs employing simultaneous illumination from multiple sources. The goal of the multiplexed measurement design is to...

Compact Snapshot Dual-Mode Interferometric System

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:57:02 GMT

This technology is an interferometric system that measures both surface shape and roughness and is designed for on-machine metrology. Background: Interferometry uses constructive and destructive interference in waves to obtain information. One common application of this field is to examine the properties of a surface, often at nanoscale. When mounted on machines, interferometers enable manufacturing at extreme levels of precision. Dual-mode inferometers use two different types of light to look at a surface and either measure the shape of a surface or its roughness depending upon the type of...

Efficient All-Fiber Amplifier based on Small Diameter Air Clad Fibers

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:55:59 GMT

This technology is a novel fiber amplifier that achieves high efficiency while reducing cladding thickness. Background: Optical fiber communications are in high demand and expected to continue to grow at a fast pace in the near future. As companies compete to take advantage of this market opportunity, there is a drive to continuously improve the efficiency of optical communications. One area with room for innovation is optical amplifiers. Signals traveling over fiber optic cables attenuate over distance, requiring amplification to travel longer distances. Optical amplifiers like this te...

Replication Method for Volume Holographic Optical Elements and Holographic Waveguide Couplers

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:52:10 GMT

This invention is a replication method for volume holographic optical elements and waveguide couplers. It is a new configuration for fabricating transmission holograms using composite master holograms and reflection holograms using a pair of master holograms. It produces a method that is scalable and able to increase the type of waveguide holograms that can be fabricated. This invention has the potential for commercial application in augmented reality displays and solar energy systems. This method utilizes successful replication techniques from prism-coupled assemblies without the drawbacks of...

Interleaved Multi-Pass Optical Amplifier

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:48:39 GMT

This invention is a multi-pass master oscillator power amplifier (MOPA). The technology is an optical amplifier, such as a laser amplifier, that has been configured so the signal cycles through the gain media multiple times. The goal of this is to better saturate the available power from the gain and greatly decrease the amplified spontaneous emission (ASE). Background: In standard oscillators, the nonlinear effect causes limitations in the output peak power and pulse energy. There is a need for a product that allows for the oscillator to have a high-output peak and pulse energy. In app...

Smartphone-Based Multispectral Dermascope

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:46:08 GMT

A rise in melanoma cases across the world and a decline in the number of dermatological specialists characterizes the outlook of global professional skin care. General practitioners can look for clues before referring patients to a specialist; and, if they have the tools, they can take high-quality diagnostic tests for further specialist monitoring. However, specialized equipment is expensive and unrealistic for family practices to carry. This invention is a low-cost, high-quality solution to the general problem. It allows general practitioners to analyze questionable skin areas to check for ...

Protein Structure Analysis using One-Step Tyrosine Conjugation

JianlingL@tla.arizona.edu — Wed, 02 Dec 2020 08:29:42 GMT

This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for a variety of applications including but not limited to evaluation of protein aggregates levels related to a particular disease (e.g., aggregate-associated disease, etc.), for study of disease progression, drug development for therapeuti...

Refractive Index Contrast Polymer Photonics Interconnects and Waveguides for Packaging and Integration

JianlingL@tla.arizona.edu — Tue, 10 Nov 2020 14:45:12 GMT

This invention represents a new chemical composition of photoresponsive, polymer photoresists, where the refractive index of the polymer can be modulated via UV radiation to facilitate the arbitrary writing of optical waveguides and other photonic devices in the material. The material can be spun on to any substrate or existing photonic device architecture and, through lithography, create polymer waveguides and enable interconnecting of individual silicon integrated photonics chips, functioning as an inexpensive optical interconnect medium. The ability to transfer an optical signal between wa...

Reconfigurable Entanglement-Enhanced Microwave Photonic Sensors for Navigation, Imaging, and Communications

JianlingL@tla.arizona.edu — Tue, 03 Nov 2020 14:24:30 GMT

This technology uses multipartite entanglement to enhance the sensitivity of microwave photonic sensors. These photonic sensors are comprised of electro-optic modulators that convert the microwave signal into an electric field displacement at a sideband frequency. Measurements that are made by the sensor nodes use this multipartite entanglement to improve performance and accuracy. Background: This invention describes a way to enhance sensitivity of photonic sensors that use entangled photons for communication. Here, using electro-optic modulators enhances the RF-to-Photon conve...

Open Source Software as a Service for Solar Forecast Evaluation

JianlingL@tla.arizona.edu — Tue, 03 Nov 2020 12:14:50 GMT

The Solar Forecast Arbiter is an open source evaluation platform for solar forecasting. The platform enables evaluations of solar irradiance, solar power, and net-load forecasts that are impartial, repeatable, and auditable. The Solar Forecast Arbiter is designed to support all solar forecasting stakeholders. Background: A major concern surrounding solar power is the variability and unpredictability of sunlight. This inherent variability poses issues with grid reliability and the expenses associated with operating the solar units. Errors in solar forecast accuracy arise either from the weathe...

We Health Arizona - COVID personal management app

JianlingL@tla.arizona.edu — Tue, 03 Nov 2020 11:50:16 GMT

This is a mobile app available at https://www.wehealth.org/arizona. COVID-19 and the research surrounding contact tracing have so far lead to one-size-fits all solutions. For example, the standard 14 day quarantine is given to all who contact a COVID-19 positive individual if that contact was less than 6 feet for more than 15 minutes. In contrast, this improvement to existing technology is a multi-variable analysis of distance, volume of exposure, and likelihood of infection to give the user a personalized recommendation for self-quarantine. There are several other apps that have used t...

DASH-WELL A Near Real-Time Geographic Information System-Based Tool for Emotion Mapping in the Built Environment

JianlingL@tla.arizona.edu — Tue, 03 Nov 2020 11:46:59 GMT

“The unprecedented circumstances surrounding COVID-19” was the pervasive buzz phrase of 2020 and post-COVID re-entry in 2021. More than ever before, businesses, universities, congregations, and communities are seeking ways to allay people’s fears, anxieties, and stress as they re-enter their workplaces and communities and come back to something that resembles normalcy. This invention provides people the information they need to reduce their stress as they re-enter. This is done by providing near real-time and real place information about factors that increase different ...

Brief Index of Sleep Control (BRISC)

JianlingL@tla.arizona.edu — Tue, 03 Nov 2020 11:37:23 GMT

This is a diagnostic index and questionnaire that assesses the degree to which an individual perceives control over their bedtime, wake time, sleep duration, and sleep quality. Background: Control over time to bed, time awake, sleep duration, and sleep quality are all related to sleep outcomes and assessment of these constructs may be useful for future sleep interventions. Modern societies are now facing challenges in achieving adequate sleep and experiencing a variety of sleep disturbances. This technology allows a health care professional to determine various aspects of a person’s sle...

Trailer-Based Mobile Observatory Enclosure

JianlingL@tla.arizona.edu — Mon, 02 Nov 2020 13:27:28 GMT

This invention is a trailer-based mobile observatory that has a roof that is stable under gravity in the both the opened and closed positions to ensure better mobility and robustness for travel while eliminating the risk of the roof opening during travel. This ensures that if there is any mechanical issue while the roof is in the closed position, the roof will remain closed. The trailer-based mobile observatory enclosure can be designed to house one or more telescopes and to enable remote and robotic operation. The enclosure is designed for easy deployment and reliable ope...

Interactive Deep Learning for ECG Monitoring

JianlingL@tla.arizona.edu — Fri, 23 Oct 2020 13:56:15 GMT

This invention is a deep learning algorithm system that can incorporate human-interpretable explanations in its training process for the analysis of ECG signals. This method takes into account classification loss, the influence of both important and unimportant features to model prediction, and user feedback. This invention is geared toward real-time ECG signals to provide clinical decision support to health care providers in the form of a web or mobile application. This technology can enable a faster and more reliable method of reading ECGs and help screen and identify important image f...

Algorithm and Software for a Quantum Molecular Non-Born-Oppenheimer Model to Predict Molecular Interactions with a Magnetic Field

JianlingL@tla.arizona.edu — Fri, 23 Oct 2020 11:50:15 GMT

This invention is an algorithm developed and implemented for a new non-Born-Oppenheimer method for atomic quantum-mechanical calculations to predict fine structure corresponding to atomic transitions for atoms or molecules in a strong magnetic field. This algorithm was programmed and tested in calculations of hydrogen deuteride (HD) in a stationary magnetic field. The splitting of the HD singlet and triplet energy levels were studied. This advancement involves using explicitly correlated Gaussian functions with shifted centers to represent the wave function dependent ...

Non-Invasive Monitoring of the Autonomic Nervous System for Real-Time Assessment of Human Stress

JianlingL@tla.arizona.edu — Mon, 12 Oct 2020 10:51:01 GMT

This innovative research uses video thermography and a novel algorithm designed to analyze changes in sweat pore activation (SPA). This technology can rival pupillometry in understanding physiological responses under various stresses and circumstances. This is a real-time, non-invasive way to detect sweat pores’ response to stimuli, both physical and emotional. In society today, mental health is acknowledged perhaps more than any other time, as universally important to an individual’s health. Physiological markers accompany certain disorders, for example PTSD, but those m...

Blocking NRP-1 for the Treatment of Pain, Cancer and Prevention of Viral Entry

JianlingL@tla.arizona.edu — Tue, 06 Oct 2020 16:35:31 GMT

This invention discloses a novel method for the treatment of pain and cancer as well as the prevention of viral entry, most notably SARS-CoV-2. The inventors have identified a number of promising lead compounds which bind to and interrupt neuropilin 1 (NRP-1) signaling. This is an important first step in the development of small molecule inhibitors that could not only be used to treat neuropathic pain and cancer, but also serve as a preventative measure against SARS-CoV-2 virus entry. Background: COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cont...

Innovative Approaches to Optimize the Therapeutic Benefit of Autophagy Inhibition

JianlingL@tla.arizona.edu — Tue, 06 Oct 2020 06:30:19 GMT

This invention is a set of novel synthetic compounds that demonstrate autophagy-inhibiting efficacy, useful for cancer and pulmonary hypertension treatment. Background: Autophagy is an evolutionarily conserved lysosomal protein degradation process. Aberrant autophagy plays a role in the pathogenesis of many health conditions including cancer, pulmonary hypertension, diabetes, neurodegenerative disorders, and others. This technology is directed to a series of novel therapeutic compounds that inhibit autophagy. Applications: Autophagy inhibitors for cancer Autophagy inhib...

Allosteric Modulators of TDP-43 for Treating Neurodegenerative Diseases

JianlingL@tla.arizona.edu — Tue, 06 Oct 2020 06:12:57 GMT

This invention is a small molecule drug, nTRD22, that can be used to treat currently incurable neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and potentially even Alzheimer’s disease (AD) and Parkinson’s disease (PD). This molecule targets the N-terminal domain (NTD) of the DNA binding protein-43 (TDP-43) and causes allosteric modulation of the RRM of TDP-43, allowing for a new way to modulate RNA binding domains (RRM1 and RRM2) and target RNA-protein interactions in neurogenerative diseases. Specifically, the nTRD22 compound, a...

Pneumatic Ventilator System

JianlingL@tla.arizona.edu — Wed, 30 Sep 2020 11:48:50 GMT

This technology describes a pneumatic ventilator system that benefits from the robustness of manufactured pneumatic elements, leveraging the existing supply of compressed air and O2. The system provides controlled breathing with adjustable frequency and adjustable plateau pressure. This technology can provide benefits for both ventilators and continuous positive airway pressure (CPAP) applications. Background: Ventilators have been a big talking point over the last few months in healthcare as the coronavirus pandemic has moved throughout the world. It has been well documented that a ven...

Tracheostomy Positioning Device

JianlingL@tla.arizona.edu — Wed, 30 Sep 2020 11:47:19 GMT

This invention is a mechanism to assist in the positioning for a tracheostomy to open the windpipe. This technology results in precise external localization of where the tracheotomy incision should be made. Background: Tracheotomy is one of the oldest procedures known to mankind. It is a medical procedure in which a tracheostomy, an opening in the windpipe, is surgically created to allow for breathing to occur through a breathing tube. Currently, tracheostomies are placed by palpitating the skin, but it is easier and more accurate to use internal features of the airway to place the...

New Device for Electropolmeric Paving and Sealing

JianlingL@tla.arizona.edu — Fri, 25 Sep 2020 14:10:16 GMT

A device for electropolymeric paving has been developed by researchers at the University of Arizona. This device includes a biocompatible implantable degradable polymeric material having integrated electrical properties useful for sensing or detecting one or more analytes, signals or conditions, transmitting or generating a signal, or releasing a therapeutic, prophylactic or diagnostic agent. The integrated electric component of the implant can locally monitor and/or modify the function of an organ or organ component. Background: The complications associated with current permanent impla...

All-Reflective Microscope

JianlingL@tla.arizona.edu — Wed, 23 Sep 2020 13:05:44 GMT

This invention is an innovative all-reflective microscope with off-axis configuration with freeform surface. This design would have uniform diffraction limit performance from UV to far-IR. Background: Reflecting microscopes, which incorporate reflecting rather than refracting objectives, are used for imaging over a wide range of wavelengths, especially in the ultraviolet and infrared regions in which conventional optical glasses do not transmit light. Typical applications include the identification of micro-contamination in commercial products or processes, the characterization of trace evid...

Repurposing of a Known Drug for Treatment of the Novel Coronavirus SARS-CoV-2 (COVID-19)

JianlingL@tla.arizona.edu — Wed, 23 Sep 2020 10:47:17 GMT

This invention introduces a novel use for an existing pharmaceutical. This new use will allow the existing drug to be used to treat COVID-19. This known drug was recently found to be effective in interacting with COVID-19 genes. This interaction has led to antiviral activity against COVID-19 in in vitro cell cultures. Background: The coronavirus pandemic has had a disastrous effect on both public health and the global economy. With over 20M cases and over 800K deaths from COVID-19 worldwide, treatments for COVID-19 are incredibly important and sought-after. This new use of an existing drug t...

Development of Aptamers Neutralizing Antibodies for Demyelinating Diseases

JianlingL@tla.arizona.edu — Tue, 22 Sep 2020 03:12:18 GMT

This innovation is research involving the development of aptamers that work to neutralize antibodies which harm the myelin sheath of nerves. The innovation can be a successful treatment for both multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIPD). These aptamers will be very specific to block certain autoantibodies and can be designed to have specific aptamer panels for each patient depending on what autoantibodies they have. The current treatments for these auto-immune diseases are non-specific and only treat the symptoms, not the underlying problems ...

Targeting TDP-43 for Parkinson's Disease Therapy

JianlingL@tla.arizona.edu — Tue, 22 Sep 2020 02:56:52 GMT

This invention is a molecule that targets the aberrant aggregation of a certain protein (TDP-43, associated with neurodegeneration) of neurons. The molecule binds to a specific site within the TDP-43 protein, and this helps prevent the unwanted aggregation of TDP-43 within neurons. The molecule has been shown to stop and even reverse neurodegeneration in experimental models. Background: Neurodegenerative diseases affect millions of people globally. Currently, most treatments for these diseases only include treating symptoms and not the root causes of the disease. In the p...

Photonic Machine Learning with Wavelength/Frequency Multiplexing

JianlingL@tla.arizona.edu — Fri, 18 Sep 2020 16:18:34 GMT

This invention is an improved method of machine learning utilizing nanophotonic devices to implement neural networks. Photons from nanophotonic devices have degrees of freedom which allow for more information to be encoded in the photons. This allows the neural network to be expanded. Signals then are encoded in different wavelengths which allow for many signals to be transmitted in a single signal that must be decoded with a similar technology. This method works best for convolutional neural networks where the same set of operations is repeatedly applied to different data. Backgroun...

Plastic Pollution Cleanup in the Ocean

JianlingL@tla.arizona.edu — Thu, 17 Sep 2020 09:15:40 GMT

This invention is a specially designed hydrocyclone, a type of cyclonic separator, that is meant to separate plastics from water. It is designed in such a way that it can filter plastics smaller than 5mm in size while returning nutrients, like plankton, back to the ocean. Background: Every year up to 8,00,000 metric tons of plastic enters our planet's oceans where it collects in circulating currents, known as gyres, or is carried to beaches. While floating, the plastic pieces break down from environmental factors like the sun and animals into smaller and smaller pieces, some of w...

High Temperature Thermal and Electrical Heating for Copper Extraction Pot

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 11:20:31 GMT

This technology uses molten salts, which are electrically conductive and can be used as an electrolyte for the electrodeposition of copper, and extracts pure copper from impure copper inputs in a single step, therefore reducing the extraction time without requiring or producing any toxic products. Background: It is expected that around 6,000 metric tons of copper will be produced using solvent extraction/electrowinning methods by 2018. With the worldwide demand for copper rising, this technology has the potential to fill a need unmet thus far. The proposed device/technique extracts p...

Heat Exchange System using Solid Particles and Fluid

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 11:17:04 GMT

This invention is a heat exchanger designed for heat transfer from solid particles to liquid inside of tubes. It consists of (1) slide particle flow and discharge belt, (2) solid particle flow distributor for particles to reach tube banks uniformly, and (3) tube bank arrangement for heat exchange. Particles fall and flow outside of the liquid tube bank providing a regulated method of heat transfer. The use of heat from solid particles can be used in industrial processes that typically are wasted to the environment. Applications: Mining application - ore transfer...

Convolutional Neural Networks for Pavement Roughness Assessment Using Calibration-Free Vehicle Dynamics

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 11:10:08 GMT

This technology is a method of identifying road roughness (i.e., International roughness index, IRI) by collecting sensor data from a smartphone app or other computing device and applying deep learning techniques to estimate the road’s roughness index. Background: Monitoring of road surface conditions is a logistical challenge. Traditionally, road condition monitoring for maintenance and repair relied on driver reporting and expensive and infrequent comprehensive surveys. As a result, roadway condition data tended to be poor quality and out of date. Recent alternative solutions ha...

High Temperature Ceramic Powder Systems

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 11:08:58 GMT

This technology is a ceramic powder composition that includes Si, N, O, C, MG, B, and combination of different crystalline phases. These combinations have the potential to create a high temperature resistant and high strength ceramic product. Background: Ceramic coatings provide a thermal barrier and a layer of protection from corrosion on high heat. This practice has been used in various industries, but mainly in spacecraft, electronics, and automotive. Being able to control the mechanical, thermal, and electrical properties in the ceramic powder is very empowering in the ability to cre...

Program for Writing Customized Exams for Large Classes with Randomized Numbers Embedded while Enabling Grading to be Done with Detail

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 11:05:37 GMT

This invention is an efficient software package/code that creates individually distinct and randomized exams that would enable faculty to feel more confident that students were doing their own work and could make cheating easier to detect. Background: Due to the COVID-19 pandemic, most universities, primary schools, and institutions have turned to online classes to reduce the spread and accommodate students and faculty. With this transition comes another set of problems mostly revolving around cheating and academic integrity. Not all proctoring solutions are ideal, cost effective, reliab...

Dynamic Capacitance Sensor Board Development

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 11:04:18 GMT

This technology is a new sensor board that converts dynamic capacitance in a sensor into an analog voltage signal. The signal created by this sensor board can then be used with any off-the-shelf wired or wireless data acquisition system. Background: Sensors are increasingly used for structural monitoring. For example, networks of hundreds of strain-measuring sensors can be attached to large structures such as bridges, to analyze their performance in real time and identify potential problems with greater accuracy than visual inspection. Existing technologies typically make use of sensor eleme...

Molten Salts for Precious Metal Recovery

JianlingL@tla.arizona.edu — Tue, 15 Sep 2020 10:58:53 GMT

This invention is a method used primarily for mining that extracts metals using electrodeposition from a mixture of refined ore and molten salt in order to reduce the melting point. Much like the process of extracting aluminum from Bauxite, gold is extracted from ore using electrodeposition as a replacement for the widely used sodium cyanide mixture. Background: Mining for precious metals like gold, silver, and copper fuel economies across the world. These metals are very commonplace--all of the major technology used on a daily basis requires these precious metals in some capacity. How...

Antibody Test for Coccidioidomycosis

JianlingL@tla.arizona.edu — Wed, 09 Sep 2020 14:25:02 GMT

This invention is a novel diagnostic test for coccidioidomycosis, also known as valley fever. Background: Valley fever (coccidioidomycosis) is a fungal disease that is a common cause for pneumonia due to spores that are swept through the air. The fungal infection can be identified in microscopic detection of specific cells within bodily fluids. A skin test is useful in suggesting infection. However, if there isn't a "conversion," the test is deemed non-conclusive. Therefore, there remains a need for a fast and precise serological test. Applications: Valley ...

Solar Tower to Dry Food Waste on a Large Scale

JianlingL@tla.arizona.edu — Wed, 09 Sep 2020 13:41:31 GMT

This invention is an innovative greenhouse designed to dry food waste at scale. This radical design maximizes the temperature gradient within the tower to minimize drying time. The solar dryer uses solar radiation, requiring minimal energy input. The dried food waste can be stored and used as needed to fertilize fields, feed livestock, or it can be sold as a commodity, turning a waste stream into a revenue stream. Background: In the United States alone, a staggering 62.1 billion pounds of fruit, vegetable, and grain waste end up in the landfill each year. This amounts to an economic loss of $...

High Performance UV Disinfection in a HVAC System with Integrated Concentrator Optics

JianlingL@tla.arizona.edu — Thu, 03 Sep 2020 16:01:22 GMT

This invention is an ultraviolet germicidal irradiation (UVGI) system that disinfects air through ultraviolet C (UVC) radiation. The system has low power consumption and high sterilization and flow rate to both neutralize airborne pathogens and filter all the air inside a room quickly without disturbing the environment inside the room. Background: Removal or neutralization of airborne pathogens from air inside a hospital, classroom, restaurant, nursing home, or store can reduce odor, allergens, and pathogens causing infectious diseases. Among the many techniques, UVGI that utilizes UVC ...

Natural Plant-Based Hand Sanitizer

JianlingL@tla.arizona.edu — Wed, 02 Sep 2020 12:19:25 GMT

This invention is a combination of plant-derived extracts formulated to mitigate bacterial and viral pathogens. This combination can be used as a natural hand sanitizer. Background: Microorganisms like bacteria and viruses are found on every surfaces. Hand sanitizer is a quick and convenient way to kill the bacteria and viruses encountered in day-to-day life. Every year, about 37 million Americans get sick with foodborne illnesses. Having a convenient way to mitigate viral illnesses has never been more important than it is now during the COVID-19 pandemic. While most hand saniti...

Cyp2f2 Knock-Out Mouse

JianlingL@tla.arizona.edu — Thu, 27 Aug 2020 13:59:33 GMT

This technology is a Cyp2f2-null mouse model that is valuable for studying the role of CYP2F2 in the metabolism and toxicity of numerous foreign compounds that can cause airway injury and disease. Background: CYP2F enzymes are abundantly expressed in the respiratory tract and are active towards many foreign compounds coming from environmental chemicals, drugs, or other compounds that enter the body through the airway. CYP2F enzymes have been difficult to study because of a lack of specific chemical inhibitors and knockout animal models. Original publication: Generation and Charact...

High Bandwidth Positive Displacement Reversible Pump/Motor

JianlingL@tla.arizona.edu — Wed, 19 Aug 2020 14:26:53 GMT

This invention is a pump system developed to serve as an artificial heart. This is an electrically driven device without fixed valves that functions with "functional equivalents" of valves via a sliding vane. The vane serves to propel flow as well as to partition flow. A high bandwidth positive displacement reversible pump/motor with two embodiments is proposed. Background: More than 5 million Americans have heart failure, with 670,000 new cases diagnosed each year. Mechanical circulatory support (MCS) devices, such as ventricular assist devices (VADs) and total artificial hear...

Imaging Human Respiratory Gas Patterns, Volume, Rate and Carbon Dioxide

JianlingL@tla.arizona.edu — Wed, 19 Aug 2020 14:17:27 GMT

This invention is a multi-camera-based system that can produce 3-dimensional (3D) images of human respiratory gas patterns, volume, rate and carbon dioxide (CO2) content through two complementary imaging techniques, combined with 3D computerized models of gas flow. Background: Acute respiratory distress syndrome (ARDS) is a major complication in patients with severe COVID-19 pulmonary disease that can manifest shortly after the onset of difficulty breathing. As ARDS onset can occur very quickly after the appearance of mild respiratory symptoms of COVID-19, it is essential to h...

A Peptide Approach to Block eNOS Phosphorylation at T495

JianlingL@tla.arizona.edu — Fri, 14 Aug 2020 14:03:29 GMT

This invention is a peptide that blocks eNOS phosphorylation. These peptides are designed to target the T495 phosporylation site of eNOS to prevent the activation of eNOS that leads to superoxide production and overwhelming inflammation. The initial peptide has been shown to reduce NOS derived superoxide and cell barrier loss throughout trials. Background: Pulmonary hypertension and ventilation-induced acute lung injuries can be devastating conditions. Pulmonary hypertension is a type of high blood pressure, which affects the arteries in the lungs and the right side of the heart. Th...

A Blockchain Solution to Connect Individuals to Health Promotion Services Outside a Clinical Setting

JianlingL@tla.arizona.edu — Mon, 10 Aug 2020 16:00:24 GMT

The proposed technology is an application that incorporates the use of blockchain technology to connect individuals to health promotion services and interventions outside a clinical setting. This application allows a provider to receive referrals from patients and the makes the referral connections. The current implementation focuses on smoking cessation. Background: As technology advances and becomes a part of our everyday activity, the potential for healthcare and patient engagement in preventative and post-discharge care becomes extremely feasible. Within the healthcare industry,...

3D Printed, Stretchable Epifluidic Platform

JianlingL@tla.arizona.edu — Tue, 04 Aug 2020 13:01:24 GMT

This technology is a 3D printed device that can be mounted on the skin and collects small amounts of sweat to measure its contents. The 3D printing technology enables the device to be custom manufactured to conform to an individual’s body and to be mounted without applying adhesives to the skin. Background: Epifluidics is a rapidly evolving area of microfluidics, where devices are applied to the surface of the skin, typically to collect tiny amounts of sweat for analysis. The sweat can then be analyzed within the device to look for particular markers. Research suggests this type of tech...

Surface Codes Based Quantum Networking

JianlingL@tla.arizona.edu — Tue, 04 Aug 2020 12:58:14 GMT

This invention uses surface codes to implement an extendable quantum communication network. Background: Quantum communication makes use of quantum physics to create highly secure networks that are immune to many techniques used to intercept the communication while in transit. But because quantum information degrades quickly, there are limitations on how far the information can travel. This limitation is addressed by placing intermediate nodes between the source and destination, which act as “repeaters” to break the transmission into several steps of shorter distance. However, exis...

Safe Specimen Transportation Isolation Container (STIC)

JianlingL@tla.arizona.edu — Mon, 03 Aug 2020 14:38:21 GMT

This invention is a portable biocontainment device particularly suited for self-collection, processing, and transportation of contagious biospecimens. The device is a two-in-one system in which both bio-fluid and gas-phase clinical infectious specimens can be collected for safe transportation and pre-processing for advanced analytical tests. Background: In the event of a disaster response, such as a pandemic infection, there is a need for collecting biological specimens from individuals who may be infected with highly infectious diseases. Healthcare professionals need to have access to sample...

Design and Development of Innovative Formulations of Resatorvid for Targeted Skin Drug Delivery and Applications Therein

JianlingL@tla.arizona.edu — Mon, 03 Aug 2020 14:32:15 GMT

University of Arizona researchers have developed a novel formulation of Resatorvid, a selective TLR4 inhibitor that was originally designed for the treatment of sepsis. This re-formulation is designed for delivery to the skin for a variety of skin diseases including early stages of skin cancer. Background: Skin cancers tend to be slow growing and can be cured with early and adequate treatment. Non-melanoma skin cancer is the most common neoplasm in countries with high rates in caucasian populations and in cases of high UV ray exposure. In the United States alone, there are more than half a mi...

Freeform Surface Metrology with Deflectometry

JianlingL@tla.arizona.edu — Wed, 29 Jul 2020 09:03:43 GMT

Deflectometry is one of the potential techniques for freeform surface metrology. The display panel is either LCD, LED, or OLD and it displays a certain pattern onto the freeform surface. The cameras then record how the pattern is distorted on the surface and this is fed into a processing unit where it calculates the surface shape. This invention involves a robust and easy to use deflectometry system for measuring freeform surfaces. The system includes three cameras, two which are positioned at the edge of the display panel and one in the middle. The processing that this invention uses consist...

Mobile Intraoral Camera Powered with Artificial Intelligence

JianlingL@tla.arizona.edu — Wed, 29 Jul 2020 09:02:52 GMT

This invention is a mobile intraoral camera which consists of a flexible intraoral probe to reach the base of the tongue and tonsillar region of the oropharynx, a mobile process unit to capture, store, process, and transfer images, and automated image processing to identify suspicious areas within the mouth. Background: Intraoral cameras are an alternative that dentists may use instead of mirrors to review and examine the mouth of patients. The added benefit of using an intraoral camera compared to a mirror is that it provides the dentist high-resolution images of a patient's mouth ...

Panoramic View Attachment for Colonoscopy

JianlingL@tla.arizona.edu — Wed, 29 Jul 2020 08:58:25 GMT

Specific colonoscopies use a colonoscope, a flexible tube with a camera attached at the end to allow for visualization of pre-cancerous growths within the colon. During a colonoscopy, the doctor uses a colonoscope that transmits an image of the lining of the colon on a screen so the doctor can examine it for any abnormalities. The current invention is a snap-on attachment with panoramic view for existing colonoscopes. The key innovation of this attachment is it is based on single-viewpoint design, covering 360-degree field of view. Background: Colon cancer is the second leading cause of deat...

Additive for Improving the Efficiency and Stability of Organic Perovskite Materials for Electronics, including Photovoltaics

JianlingL@tla.arizona.edu — Thu, 23 Jul 2020 15:48:42 GMT

This invention is a new small molecule for passivating defects in organic perovskite electronic devices that improves power conversion efficiency, device quality and higher long-term stability, even in dopant-free designs. Background: Perovskite solar cells (PSC), considered to be third generation photovoltaics, have great potential to increase solar energy conversion efficiency and decrease the cost of solar energy cell production. The highest achieved power conversion efficiency for PSCs is now greater than 24%, but the rapid degradation of perovskite materials on exposur...

Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor

JianlingL@tla.arizona.edu — Sat, 18 Jul 2020 10:44:07 GMT

The core portion of the dynorphin protein was identified and modifications were made to that core to allow dynorphin to interact and antagonize a bradykinin receptor which is partially responsible for pain sensations. Applications: Since the invention antagonizes a receptor partly responsible for pain, the modified protein can be used as a form of analgesic. Alternatively, different modifications can be made to the dynorphin to allow it to function as an anti-inflammatory compound by antagonizing different receptors. Advantages: Targets a small subset of receptors for ve...

Visible-Light Mediated Organophotoredox Catalytic Deuteration of Aromatic and Aliphatic Aldehydes

JianlingL@tla.arizona.edu — Wed, 15 Jul 2020 08:35:03 GMT

This technology is an organophotoredox strategy that enables directly converting readily accessible aldehydes to their 1-deutero conterparts. The approach is distinct from the reported transition metal catalyzed ionic hydrogen-deuterium exchange (HDE) processes. The power of this new process has not only been demonstrated for aromatic aldehydes, but also for aliphatic substrates, which have been difficult for HDE, and for selective late-stage deuterium incorporation into complex structures with uniformly high deuteration level (>90%). Background: Among isotopes, deuterium perhaps has...

Precision Brachytherapy Device for Esophageal Cancer

JianlingL@tla.arizona.edu — Mon, 13 Jul 2020 21:04:23 GMT

This invention is a novel brachytherapy multiple radiation seed delivery device. The device was developed to deliver an ablative dose of radiation to the cancerous tissue while sparing the normal tissue for patients with esophageal cancer. Background: Brachytherapy is a form of radiation therapy in which small radioactive seeds are placed near cancerous tissue to minimize damage to healthy surrounding tissue. Brachytherapy is used primarily in prostate, cervical, breast, skin, and esophageal cancer. The purpose of this invention is the application to esophageal cancer. Esophagea...

FPGA-Based Rate-Adaptive Spatially-Coupled LDPC Codes for Optical Communications

JianlingL@tla.arizona.edu — Wed, 08 Jul 2020 10:53:40 GMT

This invention discloses a rate-adaptive forward error correction (FEC) scheme based on spatially-coupled (SC) LDPC codes derived from quasi-cyclic (QC) LDPC codes with its field programmable gate array (FPGA) architecture. FPGA emulation demonstrates that the proposed LDPC codes provide larger coding gain and smaller error floor compared to the QC-LDPC base code with comparable computational complexity. The hardware friendly structure of the codes make them a promising candidate for the next-generation intelligent optical communication systems such as long-haul optical transmission system. &...

Quantum Chemical Methods for Calculations and Computation Implementation

JianlingL@tla.arizona.edu — Thu, 02 Jul 2020 11:06:54 GMT

This technology comprises software used to predict the structure and behavior of chemical species, considering quantum effects. This is used to predict atomic fine structures, particle wave functions, vibrational, and rotational states of matter with high accuracy. Background: Currently there is a growing need for enhanced and accurate molecular predictive modeling software. Historically, various mechanical models have been used to illustrate and understand molecular geometry. These methods are used in computational chemistry, drug design, computational biology, and materials ...

Gall Bladder Cryoablation Device

JianlingL@tla.arizona.edu — Thu, 02 Jul 2020 09:27:30 GMT

This device is a novel cryoablation procedure and probe to treat gallstones. The probe is designed to fit in the gall bladder. The probe will freeze and ablate the gallbladder and cystic ducts but won’t freeze other organs that are in close proximity with the gall bladder. This invention is a less invasive alternative to a cholecystectomy for healthy patients and for patients who are too ill for surgery. Background: Patients who are treated for gallstones often have to undergo a cholecystectomy to remove the gallbladder. Approximately 700,000 cholecystectomies performed a...

MultiLock: Biometric-Based Graded Authentication for Mobile Devices

JianlingL@tla.arizona.edu — Tue, 30 Jun 2020 13:27:58 GMT

MultiLock is a passive, graded, smart phone security system which runs in the background and reviews user interaction during a screen session to continuously verify user security. The system increases security level access as warranted during the session to reduce user unproductive time with security verification. This technology improves smart phone user experience via a new approach to biometric-based graded authentication. The system takes into account that users' desired security varies by application, and that methods of biometric authentication, such as facial recogni...

An Implantable Miniaturized and Soft Wireless Sensor to Monitor Tissue and Bone Deformation

JianlingL@tla.arizona.edu — Mon, 29 Jun 2020 15:53:09 GMT

This invention consists of an inexpensive implant to adhere to the bone. This device is capable of sensing bone strain, reporting loads passing through bone for extended periods of time. The implant can be used to monitor bone growth for bone segment repair for long bones or to monitor changes in bone characteristics of patients with osteoporosis. This technology has the potential to give physicians the ability to predict when a patient with osteoporosis has an impending fracture, and thus the ability to intervene and prevent further damage. Background: Osteoporosis, also known...

Li and Co Extraction using Glycine and Sodium Metabisulfide

JianlingL@tla.arizona.edu — Wed, 24 Jun 2020 15:09:39 GMT

This invention is an environmentally friendly organic acid with a reducing agent that can extract lithium and cobalt from spent lithium-ion batteries (LIB). This invention has lower environmental impact and has improved efficiency. Background: Lithium-ion batteries (LIB) have provided a means to move electronics from stationary to portable. Lithium and cobalt are the two key battery commodities. With automation being incorporated into any different industries, such as electronic vehicles, there will be an increase demand for these commodities. Environmental restrictions and economic b...

Secure, Global Quantum Communications Networks

JianlingL@tla.arizona.edu — Wed, 24 Jun 2020 15:05:01 GMT

This invention proposes a quantum network of satellites in order to provide global coverage. The idea is to have terrestrial quantum networks be connected with low earth orbit satellites and have a subnetwork of medium and greater earth orbit satellites. This invention capitalizes on the security and speed of quantum networks and common satellite communications. Background: Quantum communication takes advantage of the laws of quantum physics to protect data. These laws allow particles—typically photons of light for transmitting data along optical cables&mdash...

Using Sound to Extract and Analyze Medical Information from Patient Encounters

JianlingL@tla.arizona.edu — Wed, 24 Jun 2020 15:04:06 GMT

This invention is a system that can be used to record non-verbal vocalization and mathematically analyze the breathing sounds of patients. The breathing sounds are crucial to diagnose patients who have a chronic or acute respiratory illness. Analysis will include: HNR, NHR, EE, STE, ZCR, SR, SC, SF, jitter and shimmer. In addition, the system can integrate sound elements with neuro-linguistic programming (NLP) technology. Background: In recent years, the prevalence of respiratory diseases like Chronic Obstructive Pulmonary Disease (COPD), bronchitis, and emphysema have i...

Pseudo-Nulling Mach-Zehnder Metrology

JianlingL@tla.arizona.edu — Mon, 22 Jun 2020 14:03:17 GMT

This technology is a novel Mach-Zehnder interferometer that uses a a pseudo-nulling configuration with a converging beam, to test two optical components against each other, rather that testing one optical component against a reference component Background: As the capability of optical manufacturing has grown such that it is easy to mass produce optical components with non-symmetric surfaces, optical metrology – the process of measuring these surfaces – has also been forced to push in new directions to characterize complex optical surfaces. Various techniques have been us...

Novel Phosphorylation that Controls the Stability of Hypoxia-Inducible Factor 1 Alpha

JianlingL@tla.arizona.edu — Wed, 17 Jun 2020 18:31:27 GMT

A University of Arizona researcher has invented a polyclonal antibody against a novel phosphorylation site that is known to be correlated with increased tumor growth. Specifically, the antibody targets a phosphorylation site on HIF-1α, which is controlled by PIM kinases. Background: Anti-angiogenic therapy is a new and promising strategy for combatting solid cancers such as myeloma, leukemia, prostate and breast cancer. Angiogenesis is considered a hallmark indicator of tumorigenesis and is believed to be required for tumor growth and metastasis. HIF-1 is a master regulator ge...

Organic Semiconductors via Pyrene Oxidation with High Yield and No Metal Catalyst

JianlingL@tla.arizona.edu — Mon, 15 Jun 2020 16:01:22 GMT

This invention is an efficient, green route for oxidizing simple pyrenes without any metal-mediated catalyst or reagent, with desired product in high yield. This direct oxidation method may be used to synthesize organic semi-conductors for use as photovoltaics, transistors, LEDs while avoiding poor yields, product impurities, and expensive work-up. This method has been demonstrated for selectively oxidizing the K-region of pyrenes using a meta-free oxidizing agent to produce a pyrene 4,5-dione and/or a pyrene 4,5,9,10-tetraone compounds. Background: Pyrene compounds are polycycli...

New Method to Screen for Drugs to Treat Age-Related Macular Degeneration

JianlingL@tla.arizona.edu — Mon, 15 Jun 2020 11:46:05 GMT

This technology is a method of screening drugs for treatment of age-related macular degeneration (AMD) by culturing retinal pigment epithelium cells (RPE) and subsequently measuring the level of exosome release from the RPE cells. Utilizing this method, the level of exosome release can be correlated with AMD onset and severity. Thus, if a drug can reduce exosome release in RPE assays, then it would be a good candidate for drug development to mitigate AMD symptoms. Background: AMD is a loss of central vision that occurs in dry, atrophic, or wet, exudative forms. Most people with macu...

T-Type Calcium Channel Enhancer for TAF1 Associated Neurological Defects

JianlingL@tla.arizona.edu — Mon, 15 Jun 2020 10:27:27 GMT

This invention relates to TAF1-ID animal model and new use for SAK3 which was first developed as a T-type voltage gated Ca2+ channel enhancer for treating TAF1 intellectually disability (TAF1 ID) syndrome, an x-linked disorder caused by loss-of-function mutations in the TAF1 gene. Background: TATA-box binding protein associated factor 1 (TAF1) plays a critical role in transcription initiation. TAF1 intellectual disability (ID) syndrome is an x-linked genetic syndrome in males caused by mutations in the TAF1 gene which result in developmental delay, intellectual disability, facial dysmor...

Synthesis and Characterization of Innovative Formulations of Suramin Hydrogels for Drug Delivery and Applications Therein

JianlingL@tla.arizona.edu — Mon, 15 Jun 2020 08:02:10 GMT

This invention consists of new advanced formulations of the drug Suramin for administration by multiple routes. In addition, the invention surrounds the process and manufacturing of these newly formulated Suramin microparticles and nanoparticles so they can be effectively used in the treatment of wounds. Specifically, these new formulations would be utilized for wound healing purposes in mucositis and diabetic foot ulcers. Background: Oral mucositis is a consequence of chemotherapy and radiation treatment of head and neck cancer, the third most common cancers with nearly 550,000 cases p...

Emotional Intelligence Training (EIT) Program

JianlingL@tla.arizona.edu — Thu, 11 Jun 2020 15:52:53 GMT

The Emotional Intelligence Training (EIT) Program is a comprehensive, highly interactive, web-based training system designed to build emotional intelligence. This system will also help with emotion-regulating skills, communication, social behaviors and leadership. This is a self-paced training system compromised of a variety of interactive activities and simulations designed to develop a range of emotional and social abilities. There are 13 modules that can be completed in around 10-12 hours. Background: It is important for members of the military to have strong emotional intelligen...

eADR Software: Electronic Automation of the Calculation of Adenoma Detection Rate

JianlingL@tla.arizona.edu — Thu, 11 Jun 2020 15:50:20 GMT

This technology is a set of algorithms that are able to automate the calculation of the Adenoma Detection Rate (ADR), a widely accepted global performance benchmark on quality for screening colonoscopy. The ADR is a reportable rate of a doctor’s ability to find adenomas, attempt of endoscopic removal of polyps, and more. Background: Colon cancer is the third-leading cause of cancer deaths globally and the second highest in the United States. Regular screening tests, such as a colonoscopy, can detect forms of cancer early. Early detection allows for more treatment options and a...

Deep Learning Based PV Cell System Design

JianlingL@tla.arizona.edu — Thu, 11 Jun 2020 15:46:17 GMT

This technology focuses on enhancement of current photovoltaic (PV) cells to optimize the overall system output of solar electricity. This technology uses a microprocessor based algorithm to monitor PV output in real-time to assist in reconfiguration of PV filters, converters, and inverters parameters for optimal PV cell system performance. Background: Photovoltaic (PV) cells are products that make up the solar panel. The PV cells are critical component in the renewable solar energy products as they are the electrical component that generates electricity when exposed to photons, als...

Control (Delay or Accelerate) Hypersonic Boundary-Layer Transition

JianlingL@tla.arizona.edu — Wed, 10 Jun 2020 15:37:15 GMT

This invention is novel flow control techniques for modifying the natural to turbulent transition process of the flow in the boundary layer of vehicles, projectiles, or missiles at supersonic/hypersonic speeds. This invention is concerned with delaying the onset of transition and the subsequent breakdown to turbulence as far downstream on the vehicle as possible. As the transition process in high-speed boundary layers is associated with strong unsteadiness, large pressure fluctuations, and intermittency, it may also be beneficial to accelerate transition to quickly establish a fully turb...

Algorithm and Software for Predicting Atomic States Using Relativistic Corrections

JianlingL@tla.arizona.edu — Mon, 08 Jun 2020 15:52:08 GMT

This invention is an algorithm developed and implemented for a new non-Born-Oppenheimer method for atomic quantum-mechanical calculations to predict fine structure corresponding to atomic transitions. This algorithm was programmed and tested by comparing calculations with experimental spectra of 3P states of helium and beryllium atoms, with very accurate results obtained. This advancement involves using correction factors to all-electron explicitly correlated Gaussian functions as a practical approach to obtaining highly accurate predictions using supercomputers, ra...

Targeting 2AG Degradation for Headache

JianlingL@tla.arizona.edu — Wed, 03 Jun 2020 09:30:11 GMT

2-arachydonyl glycerol (2-AG) is a known endocannabinoid and a precursor compound for the generation of inflammatory mediators such as prostaglandins (PGs). This technology will enhance 2-AG levels and reduce PGs inhibiting enzymatic degradation. Several known compounds that work as inhibitors have been tested against the MAGL and ABHD6. The inventors are in the process of developing novel inhibitors as well. Background: According to CDC reports and the National Headache Foundation, about 55 million people in the U.S. suffer from chronic headaches—one in six Americans. Of thes...

Real-Time Monitoring of the Diffraction Efficiency of Volume Holographic Elements During Exposure

JianlingL@tla.arizona.edu — Wed, 27 May 2020 10:20:23 GMT

This invention is concerned with improving manufacturing accuracy and speed of Volume Holographic Elements (VHOEs) through more accurate diffraction efficiency measurement in real-time measurement conditions. Diffraction efficiency is an important characteristic of VHOEs, and the most basic technique for controlling the diffraction efficiency during fabrication is to use separate beams to expose the holographic material and measure the material’s efficiency. However, this technique is time consuming and requires additional equipment. Ideally, a measurement technique that used the exposur...

Snapshot Phase-Shifting Diffraction Phase Microscope

JianlingL@tla.arizona.edu — Wed, 27 May 2020 10:18:09 GMT

This invention proposes combining snapshot phase-shifting interferometry with high resolution polarization imaging to create quantitative phase maps from diffraction microscopy. A polarization grating separates the incident beam into object and reference beams, and a digital camera captures four phase-shifted interferograms from polarization filters to reconstruct a high spatial resolution phase map. Due to the common path configuration and snapshot feature, the proposed system provides a feasible way for real time quantitative phase measurement with minimal environmental impact...

Photonic Quantum Computing Using Entangled Squeezed State Clusters

JianlingL@tla.arizona.edu — Wed, 20 May 2020 11:17:59 GMT

This invention is a scalable method for quantum computing using photonic qubits. Rather than using superconducting, this invention uses photons as a method of encoding a qubit making endless large-scale abilities. Background: As data gets bigger and expectation times for computing become shorter, there is a need to create faster computing components. In order for this to happen, a larger number of qubits must be used. This will allow for faster computing from the technology at hand. Many of the current attempts at quantum computing are not much faster or as fast as current classic a...

Discovery of T-Type Calcium Channel Antagonist from Multicomponent Reactions and their Application in Paclitaxel-Induced Peripheral Neuropathy

JianlingL@tla.arizona.edu — Fri, 15 May 2020 11:32:04 GMT

This invention uses innovative selective T-type antagonists in order to ease pain involved with chemotherapy-induced peripheral neuropathy (CIPN). Background: Chemotherapy remains a frontline treatment for many forms of cancer, however, chemotherapy agents commonly cause severe side effects such as CIPN. While opioids have been used to manage CIPN, the side effects of opioid use are often more overbearing than their benefits. CIPN is found in 64% of cancer patients from the beginning to the end phase of the cancer cycle and no effective treatments currently exist for CIPN-specific pa...

Joint QKD-Post-Quantum Cryptosystems

JianlingL@tla.arizona.edu — Wed, 13 May 2020 12:30:25 GMT

This technology is a joint quantum key distribution (QKD)-post-quantum cryptosystem. The QKD is used for raw-key transmission and post-quantum crypto-system to transmit parity bits for information reconciliation. The technology can be further advanced by encoding either Slepian states-based encoding or OAM encoding. This would help overcome the low-spectral efficiency of time-phase-encoding but the complexity of the QKD hybrid system would increase. The proposed system is able to achieve a record transmission distance of 1127 km. Background: The need for secure communications has bec...

Quantum Computing Architecture based on Large Scale Multidimensional Continuous-Variable Cluster States in a Scalable Photonic Platform

JianlingL@tla.arizona.edu — Wed, 13 May 2020 12:28:46 GMT

This technology is a one-way quantum computing architecture that is based on programmable large-scale continuous variables states. The technology is based on two distinct fields: Kerr microcombs and continuous-variable quantum information. This architecture is able to accommodate hundreds of simultaneously addressable entangled optical modes multiplexed in the frequency domain and an infinite number of sequentially addressable entangled optical modes in time domain. Background: Quantum computing has been thought of as a disruptive technology believed to be capable of addressing classi...

A Hybrid Geopolymer-Biopolymer Cementitious Material for Enhancing Pumpable Roof Support in Underground Mining

JianlingL@tla.arizona.edu — Wed, 13 May 2020 12:26:09 GMT

This invention is a new hybrid cementitious material that has a high viscosity rate to be used in pumpable roof support application in underground mining. This hybrid is a fusion of geopolymer and biopolymer that results in a high load stiffness, high peak strength, and large residual strength compared to current cementitious material used in this application. This increases the safety of underground mining. Background: Underground mining is essential for acquiring materials in everyday use. Underground mining consists of digging tunnels and/or shafts into the earth. As the...

Bed-Sled 2

JianlingL@tla.arizona.edu — Tue, 12 May 2020 10:58:33 GMT

This invention is a resistance-training device with the purpose of strengthening the lower extremities, preventing muscle de-conditioning and overall weakness, and a formation of blood clots. Background: Surgical patients and members of the elderly population are at an increased risk for developing a blood clot in their lower extremities due to a lack of physical activity. This potentially fatal condition can be prevented with increased attention to the conditioning of leg muscles. The lackluster presence of devices tailored to this condition in the rehabilitation technology market could allo...

Improvements to Minimally Invasive Percutaneous Guide for Hip Fracture Fixation

JianlingL@tla.arizona.edu — Thu, 07 May 2020 14:44:28 GMT

This invention is a design for a minimally invasive dynamic hip screw guide that will fix the position and angle in the frontal plane for the intramedullary rod. This device is a guide that can be placed on the leg rather than directly on the bone, allowing for a procedure that is significantly less invasive. This current adaptation of the invention includes aspects considered to be improvements to the already patented design. Background: Intertrochanteric hip fractures are most commonly treated with a sliding hip screw implant. These fractures are most common to the elderly, where surge...

Breast Tumor Targeted Fluorescence Guidance for Intraoperative Margin Assessment

JianlingL@tla.arizona.edu — Thu, 07 May 2020 14:42:04 GMT

This technology is an anti-CEACAM6 antibody tagged with fluorescent labels. The idea is that these fluorescent antibodies can be used for real-time molecular fluorescence imaging to help guide the surgical removal of a tumor. This technology is targeted toward breast cancer. Background: Over half of the 270,000 breast cancer diagnoses in the United States are for early stage disease; this is the population of women who will ultimately benefit from this research. A majority of these women will be candidates for breast conserving surgery, which consists of removal of the primary breast cancer w...

The Use of Active Flow Control on Combined Tiltrotor & Tiltwing Airplanes

JianlingL@tla.arizona.edu — Fri, 01 May 2020 10:47:59 GMT

This technology is a method to eliminate moving control surfaces on the wing, prop, tail and other surfaces of a tilt wing airplane. It accomplishes this by utilizing active flow control measures. The end result is a combination of tilted wing with active flow controls designed to reduce the power demand of the tilt rotor wing aircraft. Reduced power demand enables aircraft to expand their payload capability. Background: Currently, aircraft have bulky and heavy wings and tail rudders that affect the aerodynamics. The adoption of active flow control systems can improve various aspect...

CycleSafe - Proximity Sensing, Warning, and Reporting Device

JianlingL@tla.arizona.edu — Fri, 01 May 2020 10:43:53 GMT

This technology is a bicycle handlebar-mounted device. The device has a sensor that can detect when a car is too close to warn bicyclists of encroaching vehicles and provides a visual alert to the car’s driver to promote a safe passing distance from the bicyclist. The device can also take and store a picture of the vehicle and license plate for reporting to authorities if needed. Background: States generally have laws that mandate that an automobile must give a bicycle a minimum amount of space while passing on a road. The reality is that this rule is seldom followed. For...

Quantum Random Number Generator

JianlingL@tla.arizona.edu — Fri, 01 May 2020 10:37:35 GMT

This invention is a quantum random number generator (QRNGs) that provides a method to generates numbers that are mathematically guaranteed to be random at the highest rate allowed by current methods. This new method leverages quantum computing systems standard practices and enhances the confidence of randomness to the numbers that are generated for industry use. Background: This invention applies a higher level of certainty of randomness to random number selection as it pertains to usage in the national defense and cyber security. Cybersecurity and digital privacy systems...

ASLM Headset Display by Stacked Waveguides

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 14:21:53 GMT

This invention involves beam steering to increase the field of view (FOV) of augmented reality headsets or smart-glasses while maintaining true RGB color with minimal distortion. The invention uses angle-dependent image projection with micro-mirrors operating at 30 hz to create a 90 degree x 30 degree FOV with 1 arcmin/pixel resolution at 24-bit RGB color. The goal of the invention is to build a proof of concept demonstrating a design to achieve a full color, wide FOV, high resolution display with a large eye-box and high photon throughput to maintain brightness. Backgr...

Adjustable Full Stokes Polarization Eyewear

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 14:18:41 GMT

This technology is a method for tunable polarization lenses for eyewear. Individuals have the ability to tune the polarization of their lenses based on environmental inputs and their preferences. With this full range of tunability, users are able to maximize their view without having to use just one polarization type for all environments. Background: Currently, there is a wide range of lenses that are offered to individuals when they are looking to purchase eyewear products. Each of these different types of lenses offers a slightly different view and may offer additional eye benefit...

Reconfigurable Polarization Imaging System

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 13:45:55 GMT

This technology is a reconfigurable snapshot polarimetric imaging method for the color camera. The method measures polarization properties with spectral-polarization filters. This method has the ability to collect circular or elliptical polarization information. Background: Polarization imaging is described as the ability to describe light through reflecting objects. Currently, there are a few common methods that are being used. First, is the division of time which grants users with a high spatial resolution but the temporal resolution is not as strong. Then there is the divisi...

Waveguide for Angular Space Light Modulator Display

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 13:40:14 GMT

This invention is a specialized waveguide design that is tuned to the unique Angular Space Light Modulator (ASLM) angle dependent pattern output. This achieves an extended field of view (FOV) output, which is small enough to be integrated into a headset with packaging as small as a typical pair of glasses. This compactness and wide field of view is the ultimate goal for the Virtual Reality (VR)/Augmented Reality (AR) headset industry. Background: Current VR and AR headsets have a limited field of view that restricts them reaching their full capabilities. The use of typical Spat...

Complex Diversity for Inverse Problems

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 12:40:56 GMT

This invention is a new technique called complex diversity which improves performance of single shot phase retrieval algorithms used in many areas including adaptive optics, microscope imaging, and virtual reality. Background: Phase retrieval is a technique to measure unknown extrinsic phase disturbances, which is attractive because of its simplicity compared to more complicated systems that involve interferometers or Shack-Hartmann sensors. Phase retrieval drawbacks include the requirement of multiple image acquisitions (“shots”), low accuracy, and stagnation issues.&nbs...

Smartphone-Based Epifluorescence Microscope

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 12:21:30 GMT

This invention describes a smartphone-based microscope developed for the purposes of increasing the quality of current smartphone-based microscopes without adding additional costs. By utilizing exact measurements and calculations, the claim of the invention is that it can better preserve image quality and improve the field of view when used in conjunction with a smartphone. The quality of the smartphone-based microscope is like a common bench microscope often used in medicine and industry. Background: Microscopes for clinical applications cost anywhere from several hundred dollars t...

Aperture Designs To Minimize Diffraction Noise

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 12:08:12 GMT

This invention is a new aperture design to eliminate deleterious diffraction effects when trying to observe a dim object next to a very bright object, such as a planet next to a star. The novel aspect is in the design and shape of the edges of each pupil section that makes up the aperture. This design reduces the non-uniform distribution of background radiation and enables high fidelity digital image reconstruction with less noise. Background: Today, large aperture telescopes use segmented primary mirrors that are periodically discontinuous with straight lines. These discontinuities, ...

Solar Generator with Two-Stage Optical Concentration Onto PV Cells

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 11:42:50 GMT

University of Arizona researchers have developed a photovoltaic (PV) solar power generator that leverages optical design principles to obtain high power conversion performance and the robustness of operation at lower cost. Background: As competition continues to grow within the solar power market, more efficient and less costly solar power systems are in high demand. This technology addresses that demand by providing a high performance optical design that focuses light onto multi-junction PV cells, thereby increasing efficiency and reducing cost for the power generated. Appl...

Tandem Photovoltaic Module with Diffractive Spectral Separation

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 11:40:11 GMT

Researchers at the University of Arizona have developed a design for a solar concentrating device that has a solar tracker and a diffractive grating as a part of the entrance window or glass for the sunlight to enter through. The technology is designed for use in conjunction with a solar cell for solar panels. The grating delivers specific diffracted orders of light to matched semiconductor material with different band gaps (high and low). The novel grating design can deliver four times the amount of concentrated sunlight than competing designs. Background: Solar technology has prove...

Achromatic and Polarization Adaptive Optics System

JianlingL@tla.arizona.edu — Wed, 29 Apr 2020 10:54:02 GMT

This invention is an adaptive optics (AO) system for broadband and/or polarization dependent light. The system includes a wavefront sensor and compensator, and the compensator splits the broad waveband into different wavelength and/or polarization states, applies compensation, then recombines the light into a single wavefront with distortions that may be compensated by following optical elements of the AO system. The wavefront compensator is based on known optical corrections techniques but applied in a new way. The area of adaptive optics and correction techniques applied to optical signals ...

Stable, Organic Homogenous Photocatalysts Without Expensive, Rare Metals

JianlingL@tla.arizona.edu — Mon, 27 Apr 2020 13:47:46 GMT

Novel carbenium-based molecules have been designed, synthesized, and tested for use in homogenous photocatalysis. These compounds are redox active, stable, earth-abundant, easy to synthesize, and the molecular design is tunable. These compounds may also be used as highly fluorescent dyes with long lifetimes. Background: Heterogeneous photocatalysts are limited by system constraints, including inefficiencies in energy utilization, turnover, chemical species mass transport, and need for surface area for photon exposure. Homogenous and heterogenous catalysts may require rare and expens...

Multiple-Wavelength Quantitative Phase Imaging Technique

JianlingL@tla.arizona.edu — Wed, 15 Apr 2020 13:27:17 GMT

This invention is a new way to apply adaptive optics principles to image properties of biological cells. This method uses multi-spectral digital holographic imaging and random phase masks to extract phase maps comparable to maps from traditional quantitative phase imaging (QPI) optical systems though with less complication and expense. This method provides a fast, low-cost method for acquiring detailed multi-spectral data for cell objects. Background: Imaging biological cells and tissues is central to research and medical diagnosis, and imaging tissues requires contrast to distingui...

Method of Measuring Distorted Illumination Patterns and Correcting Image Artifacts in Structured Illumination Imaging

JianlingL@tla.arizona.edu — Wed, 15 Apr 2020 12:15:03 GMT

This technology is an improvement to the well-established microscopy technique structured illumination microscopy (SIM), which uses a periodic structured pattern of light to image a sample. In SIM, it is common for artifacts to arise during imaging, because the pattern is often distorted due to aberration and index mismatches in samples. These artifacts distort the image and reduce the amount of information that can be extracted from the raw data. This technology is capable of correcting distortions in challenging experimental situations, such as strong background scattering, low signal-t...

Fabrication, Design and Application of High Resolution Patterned Polarization Filter

JianlingL@tla.arizona.edu — Wed, 15 Apr 2020 12:04:11 GMT

This invention describes achromatic polarization filters that can be integrated with a complementary metal–oxide–semiconductor (CMOS) and charge-coupled device (CCD) detector array to form a polarization camera. The proposed variants of pixelated polarization filters would have applications in display and sensor designs and could cover light sources, such as organic light emitting diodes or liquid crystal light panel, to form a polarization display which can display an image of arbitrary polarization states. This is a patent-dense area, and the novelty in this invention is that th...

Bioactive Compounds for Use in Inhibiting SARS-CoV-2 Viral Replication

JianlingL@tla.arizona.edu — Wed, 15 Apr 2020 09:02:23 GMT

University of Arizona inventors have discovered inhibitors targeting the SARS-CoV-2 main protease. These inhibitors have potential for use as therapeutics against COVID-19 as well as other SARS and MERS strains. Background: Viral outbreaks are not new; we have faced SARS, MERS, Nipah, Zika, and several other viral outbreaks in recent history. In late 2019, a novel coronavirus, SARS-CoV-2 (which causes COVID-19), started to circulate through humans. The World Health Organization declared this outbreak a pandemic due to its high transmission rates. COVID-19 is a beta coronavirus, similar to th...

Method, System and Device for Determining Muscle Function

JianlingL@tla.arizona.edu — Wed, 15 Apr 2020 08:46:10 GMT

This technology includes a system, method, and device capable of simply and rapidly measuring muscle function, thereby determining or detecting fatigue, frailty, or decline or muscular function. Despite the clinical significance of this data, there is currently no simple and effective method suitable for routine in-clinic assessment of muscle function. This technology’s strength lies in its ability to produce reliable data while also being inexpensive to assemble for the clinic and easy to use for the patient. It has the potential to enable rapid, cost-effective, and reliable collection ...

Nonlinear Ultrasonic Techniques for In-Situ Process Monitoring of AM Components

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:53:28 GMT

This technology is a method to detect defect formation in additively manufactured metal parts through the building process. It will provide real-time process monitoring and process control in a non-invasive and non-destructive fashion. This method can be used with various types of manufacturing. Currently, it can be used with laser and e-beam powder bed fusion, directed energy deposition and binder jet based additive manufacturing. It is essentially a readymade method for in situ process monitoring and control without having any effect on the underlying building process. Background: ...

A Method to Create Exponentially Complex "Classically Entangled" States in Arrays of One-Dimensional Nonlinear Elastic Waveguides

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:48:22 GMT

This technology demonstrates a theoretical new approach to achieving exponentially complex non-separable superpositions of elastic waves in an externally driven elastic system composed of one-dimensional elastic wave guides and nonlinear forces. This nonlinear elastic system is similar to a two-partite two-level quantum system but does not have drawbacks such as decoherence and wave function collapse. Background: Quantum computing is an approach to computing based on the principles of quantum theory, which state that subatomic particles can exist in more than one stat...

The Use of Active Flow Control to Increase the Acceleration of Airplanes on Takeoff and Reduce the Dependence on Rotation

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:42:46 GMT

The technology is the utilization of active flow control (AFC) technology in the leading edge to improve the process of airplane takeoff. It will allow for airplanes to perform a take off without rotating. The AFC technology would allow for the airplane to take off with minimal rotation. The small rotation allows the ability to use smaller landing gear size and in result reduces the overall weight of the aircraft. Background: A notable challenge in aviation and in particular naval aviation is reducing the length required for takeoff and landing runs. Currently, flaps and slats are b...

The Use of Active Flow Control to Eliminate Vertical Stabilizers and Moving Control Surfaces

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:40:09 GMT

This technology will use sweeping jet actuators to replace the moving control surface on an airplane tail vertical stabilizers. Background: With the aviation industry looking for methods to reduce the amount of material it takes to create an aircraft, there is a need to find alternative designs with less material. Reduced material in producing aircrafts is also favorable because it can result in decreased fuel utilization. Currently vertical stabilizers and rudders are primarily used conjunction with other moveable control surfaces to maneuver aircrafts. The present invention will r...

Open Loop Pointing Technique for Orbital Laser Communications

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:30:03 GMT

These inventions are components of a satellite based communication system using nanosatellites called CubeSats. These cube-shaped satellites developed by NASA are approximately four inches with a volume of about a quart and weighing three pounds. The integrated system uses clusters of tethered CubeSats and commercial components that communicate through secure transfers with one another and a ground-based terminal. The tethering allows movement among the satellites for independent pointing while maintaining the cluster. Deployment of multiple clusters enables global communication coverage with...

Spherical Robots for Off-World Surface Exploration

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:18:58 GMT

This invention is a smart spherical robot to perform rapid mapping, ground awareness and synthesizing life-data for real-time use. The system is compact and is intended to withstand environments on other planets. Background: Rapid advancement in electronics, sensors, actuators and power have resulted in shrinking devices and instruments for robotic application. Development of real-time geo-mapping is an application that will greatly benefit space exploration and provide safety within the defense industry. The need for real-time geo-mapping will greatly assist in both these...

Low Tension Tether System to Constrain Satellite Clusters and Permit High Bandwidth Communications

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:17:21 GMT

Nanosatellite Based Low Cost Laser Communications Network for Low Earth Orbit

JianlingL@tla.arizona.edu — Tue, 14 Apr 2020 21:17:11 GMT

Design and Synthesis of Pro-Drugs for Selective, Oral Delivery to the Gastrointestinal Tract

JianlingL@tla.arizona.edu — Mon, 13 Apr 2020 09:18:27 GMT

This invention provides a method for oral administration and targeted delivery of pro-drugs bonded to a carbohydrate-based molecular scaffold to the gastrointestinal tract, where the pro-drug is released directly in the gastrointestinal (GI) tract by nitroreductase enzymes naturally present. This technology provides a means of delivery of GI therapies for a number of indications without requiring metabolism through the liver or other systemic exposure. Background: As one example of GI disease, colorectal cancer is the third most commonly diagnosed cancer in t...

Polyols from Elemental Sulfur and Elastomeric Polyurethanes

JianlingL@tla.arizona.edu — Fri, 27 Mar 2020 15:41:12 GMT

This invention consists of novel sulfur-based polyol polymers which are highly soluble in polar organic solvents and are made in a single chemical step from elemental sulfur. This chemistry enables new polyurethane compositions from sulfur comonomers. The method of synthesis can be easily scaled to large-scale production, and can be processed into water or polar solvent-based formulations. The material may be sprayed or processed into films. Various product families can be made with available polymers used as termonomers. Background: Research efforts have ...

Sulfur Based Polyols for Polyurethanes and Novel Polymeric Materials, including Nonhalogenated Flame Retardants

JianlingL@tla.arizona.edu — Fri, 27 Mar 2020 15:08:15 GMT

University of Arizona researchers developed flame retardant sulfur-based polymers that are highly soluble in polar solvents and are made in a single chemical step from elemental sulfur, a low-value byproduct of oil refining and gas processing. This chemistry enables new polyurethane compositions, including non-halogenated flame retardants. The method of synthesis can easily be scaled up, and the polymers can be formulated with polar solvents. The material may be sprayed or processed into films. Various product families can be made with commercial polymers used as termonomers. This techno...

Segmented Optical Component

JianlingL@tla.arizona.edu — Wed, 25 Mar 2020 13:36:25 GMT

This technology combines diffraction and refraction in a multi-order diffractive optical surface that is an extension of Fresnel lens technology that reflects numerous orders of wavelengths in a wide bandwidth that is constrained by the refractive dispersion of the lens. This has the advantage of collecting and focusing broader wavebands of light than standard achromatic lenses but at a fraction of the volume and weight. Background: Currently, there are a number of reflective and refractive systems that are used in different types of optical applications. Fresnel lenses with sh...

Retinal Resolution and Single-Chip Multiplexed Image Transfer for AR Near-to-Eye Displays

JianlingL@tla.arizona.edu — Wed, 25 Mar 2020 13:33:02 GMT

This invention is a single-chip, field of view (FOV) selective, and variable resolution image projection design for augmented reality near-to-eye displays (AR-NEDs). The disclosure lays out the design for a multiplexed full color image transfer via single image guide, to achieve design requirements such as full color, 90 degrees FOV, and retinal image resolution. Background: For mobile augmented reality near-to-eye displays (AR-NEDs), reduction of size, weight, cost, and power of display optics is highly anticipated while increasing resolution, field of view (90 ...

Co-doping of Holmium (Ho) and Dysprosium (Dy) with Erbium (Er) for Low-Cost High-Efficiency Diode-Pumped Laser at 3-Micron Meter Wavelength Range

JianlingL@tla.arizona.edu — Wed, 25 Mar 2020 13:30:57 GMT

For many applications, the output of a laser diode is coupled into an optical fiber to direct the light beam more easily. This fiber can be doped with rare earth metals such as Erbium to increase efficiency and absorption. Instead of using Erbium (Er3+) exclusively for doped fiber lasers, this method proposes the use of codoped Er3+ fiber lasers with Holmium (Ho3+) and Dysprosium (Dy3+). Current Er3+-doped lasers can only reach the 2.8-2.9 micron wavelength range but deliver a high power output. Ho3+/ Dy3+-doped lasers lack the power output of Er3+-doped lasers but are able to reach wavelengt...

Rayleigh-Raman Polychromatic Laser Guide Star

JianlingL@tla.arizona.edu — Wed, 25 Mar 2020 13:29:32 GMT

A Rayleigh-Raman polychromatic laser guide star is implemented in an adaptive optics system to allow for the measurement of the tilt at the wavelength of observation. This technology makes use of the dispersion of the refractive index of and on or more differential tilt measurements at multiple wavelengths returned from the Rayleigh-Raman spectrum. Background: Adaptive optics systems require wavefront tilt compensation. Existing tilt measurement systems rely on light from a source that traverses the medium in a single. Laser guide stars create a reference source anywhere in th...

Novel Compounds that Selectively Inhibit HSP70 Isoforms for the Treatment of Cancer

JianlingL@tla.arizona.edu — Fri, 20 Mar 2020 10:15:58 GMT

These compounds target a specific peptide binding domain of Heat Shock Protein 70 (HSP70) isoforms. The method in which these compounds have been derived allows for HSP70 isoform specificity. Many HSP70 targeted drugs have been unsuccessful due to the variety of HSP70 isoforms, and lack of specificity to a particular isoform. Background: Cancer cells have an increased burden on protein quality control machinery due to their rapid growth rates and the required transforming mutations that can produce unstable proteins. This increased need has led to the development of drugs target...

Close Range PET

JianlingL@tla.arizona.edu — Wed, 18 Mar 2020 15:10:52 GMT

This invention involves moving the detector ring of a PET system closer to the patient while improving the spatial resolution and reducing the blurriness of resulting images. By moving the detector module closer, the quantity of samples tested, and the solid angle covered by the scanner are increased. Background: Currently, PET system’s sensitivity is very limited and has poor spatial resolution. With these problems comes longer scan times and inaccurate diagnoses which can affect the lives of patients. PET scanners are mostly used for cancer, brain disorders, and heart conditi...

Shelf-Stable Reagent for Bioconjugation and Protein Labeling

JianlingL@tla.arizona.edu — Tue, 17 Mar 2020 12:01:15 GMT

This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine for a range of pH levels. The probes of the present invention may be used to label proteins in a fluorescent manner, for purification, imaging, or general protein modifications. The long shelf life makes this invention suitabl...

High Verdet Constant Polymer Magnetic Nanoparticle Materials for Magneto-Optic Devices

JianlingL@tla.arizona.edu — Tue, 10 Mar 2020 11:51:13 GMT

University of Arizona researchers have developed high Verdet constant thin films using polymer-nanoparticle composite material. The invention provides for uniform distribution of nanoparticles in a polymer matrix. The resulting inexpensive material possesses very high Verdet constants, exceeding one million / T-m. This material enables replacement of Faraday rotator “garnets” with thin polymer films and/or expand the use of high Verdet materials via closely integrated optical systems, especially for telecommunication. Background: Materials with a high Verdet constant are...

Single Copy Level Detection of Virus through Particle Counting on Paper Microfluidics Using Smartphone Based Fluorescence Microscope

JianlingL@tla.arizona.edu — Mon, 09 Mar 2020 15:44:35 GMT

University of Arizona inventors have detected norovirus on a microfluidic paper analytic device without using any sample concentration or nucleic acid amplification steps. This technology uses a smartphone-based fluorescence microscope and an image-processing algorithm to isolate the particles aggregated by antibody-antigen binding. This leads to a limit of norovirus detection as low as 1 genome copy/µL in deionized water and 10 genome copies/µL in reclaimed water. Background: Noroviruses are a group of non-enveloped, single-stranded RNA viruses that can cause inflammat...

Acute Hepatopancreatic Necrosis Disease (AHPND) Control Using Plant-Derived Natural Extracts, and Thereof

JianlingL@tla.arizona.edu — Mon, 09 Mar 2020 15:39:07 GMT

This technology is an antimicrobial phytogenic supplement to therapeutically treat Acute Hepatopancreatic Necrosis Disease (AHPND) in shrimp. AHPND is caused by a Vibiro parahaemolyticus producing toxin and is a threat to sustainable shrimp farming globally. Plant-derived extract NE05 is effective at controlling AHPND and potentially other bacterial pathogens in shrimp, and it is the most efficacious among the natural extracts screened. NE05 is a potential candidate to develop AHPND therapeutic treatment and is delivered directly in the shrimp diet. Background: Shrimp is ...

Design and Application of New Split-Luciferase Enzymes

JianlingL@tla.arizona.edu — Mon, 09 Mar 2020 10:16:24 GMT

UArizona researchers have developed a new split-firefly luciferase enzyme method for measuring protein-protein interactions for assays or sensors. This new method may, when combined with previous split luciferase methods, enable assays for two different protein interactions simultaneously, as well as provide a means for additional biophysical characterization. The method also has improved signal-to-background ratios. Background: Protein-protein interactions (PPls) are literally the glue that holds life together. Strategies to monitor PPIs in cells allows for biophysical characteriza...

Differential Target Antenna Coupling (DTAC) Method for Subsurface Analyses

JianlingL@tla.arizona.edu — Fri, 06 Mar 2020 08:12:06 GMT

Researchers at the University of Arizona have developed an electromagnetic geophysical system that has significantly improved subsurface target sensing and imaging capabilities compared to conventional subsurface measurement systems such as ground penetrating radar. The Differential Target Antenna Coupling (DTAC) method in a vertical array provides a number of important advantages over the large-offset horizontal array for some applications. Advantages: The vertical array, DTAC method can be adapted to rapidly moving measurements, such as from a helicopter The DTAC method is not sen...

Selective Melanotropin Ligands for Neurodegenerative Diseases including Parkinson's

JianlingL@tla.arizona.edu — Thu, 05 Mar 2020 07:58:57 GMT

This technology involves administering an α-melanocyte-stimulating hormone through a carrier to selective melanotropin receptor ligands to treat neurodegenerative diseases. Specifically, this technology allows melanotropin to be administered through either one or both, the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R). Background: There is a significant need for therapeutics to treat neurodegenerative disorders. In particular, Alzheimer’s disease afflicts more than 46 million people every year at substantial healthcare burden. In 2...

Proteins from Asthma-Protective Amish Farm Dust

JianlingL@tla.arizona.edu — Wed, 04 Mar 2020 13:41:27 GMT

This technology involves eight proteins that have been identified from fractions of Amish farm dust, which have been shown to protect against asthma in mice models. These eight proteins consist mainly of environmental allergens that can induce an immune response and have the potential to be utilized for allergen immunotherapy to help protect against and treat asthma. Background: Over 300 million people worldwide suffer from asthma, a condition that is characterized by the inflammation of the airways making it difficult to breathe. Current strategies to prevent asthma rely ...

Methods for Practical Synthesis of Deuterated Amino Acids

JianlingL@tla.arizona.edu — Tue, 18 Feb 2020 09:46:50 GMT

This invention is a new and improved method of producing amino acids labeled with deuterium, an isotope of hydrogen. Deuterium-labeled amino acids are used in a wide and increasing variety of applications, including the study of metabolic pathways, the study of protein structure, and decreasing drug toxicity while increasing potency. This invention can create more types of deuterated amino acids than existing methods and is more cost efficient. It is also simpler and requires fewer steps — making it a promising approach to satisfying the increasing demand for deuterium-labeled amino aci...

Automated Lipid Exchange-Mass Spectrometry System

JianlingL@tla.arizona.edu — Tue, 11 Feb 2020 12:22:56 GMT

This invention is an automated label-free method to measure the affinity of membrane proteins for lipids by using conventional small molecule mass spectrometry (MS) to monitor lipid exchange between lipoprotein nanoparticles called nanodiscs. We call this method lipid exchange-mass spectrometry (LX-MS). The concept is that if a membrane protein binds a certain type of lipid, it will shift the equilibrium distribution of lipids between empty (tagged) nanodiscs and membrane protein (untagged) nanodiscs. We quantify the equilibrium distribution by measuring the lipid composition in the memb...

Packed Bed Scintillation Particles for Radioisotope Detection and Separations

JianlingL@tla.arizona.edu — Fri, 07 Feb 2020 13:29:06 GMT

University of Arizona researchers have developed hydrophilic scintillation microparticles made with polystyrene cores, doped with a scintillator material, and encapsulated with a thin silica coating. The resulting microparticles are hydrophilic and can be easily surface modified to provide a variety of purposes in radioisotope activity detection, such as scintillation proximity arrays, particle-packed cartridges, separation columns, or sensors. Background: Radioisotopes are used as molecular tracers in a variety of assays and liquid scintillation cocktails. Scintillation partic...

High-Efficiency, Stable Organic Thin Film Hole Transporting Material for Perovskite Solar Cells

JianlingL@tla.arizona.edu — Wed, 05 Feb 2020 14:11:13 GMT

This invention is a new organic hole transporting material (HTM) for perovskite solar cells, which provides improved power conversion efficiency, as well as thin films with improved quality and higher long-term stability, even in dopant-free designs. Background: Perovskite solar cells (PSC), considered to be third generation photovoltaics, have great potential to increase solar energy conversion efficiency and decrease the cost of solar energy cell production. The highest achieved power conversion efficiency for PSCs is now greater than 24%, but the rapid degradation of p...

Stable, Earth Abundant, Redox-Active, Homogenous Photocatalysts

JianlingL@tla.arizona.edu — Mon, 03 Feb 2020 13:16:47 GMT

This invention opens a new class of homogeneous photocatalysts. This invention overcomes current system limitations by creating a new class of carbenium-based compounds which are stable and redox active, comprise earth abundant and inexpensive materials, have a tunable design, and are easy to synthesize at moderate to high temperatures. These compounds may also be used as highly fluorescent dyes with large extinction coefficient and long fluorescent lifetimes. Background: Heterogeneous photocatalysts are limited by system constraints, including inefficiencies in energy utiliza...

Broad-Spectrum Antivirals Against Enterovirus D68, A71, and Coxsackievirus B3

JianlingL@tla.arizona.edu — Mon, 03 Feb 2020 12:20:15 GMT

This invention is a set of compounds which have antiviral activity against the enteroviruses D68, A71, and coxsackievirus B3. They can be used both prophylactically, to prevent infection, and therapeutically, to treat it. Background: Enteroviruses are a group of viruses that belong to the Picornaviridae family. One enterovirus, the polio virus, reached epidemic proportions in the early 1900s, causing paralysis in many people. While polio has been eliminated in most developed countries, the other enteroviruses are just beginning to cause serious disease. In 2014, almost 2,000 people ...

pH Releasable Linkers for Drug Delivery, Imaging, or Diagnostics

JianlingL@tla.arizona.edu — Mon, 27 Jan 2020 15:06:48 GMT

This technology describes water-soluble triazabutadienes as cross-linkers to and protecting groups for small-molecule therapeutics or fluorescent moieties. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling targeted delivery of the cross-linked molecule. Background: Cross linking is becoming a valuable practice in chemistry, including for life science applications, with the advent of mass spectrometry. Using cross-linking and "click-chemistry" can enable unique chemical manipulations of linked proteins for...

Targeted Therapy for Itch

JianlingL@tla.arizona.edu — Mon, 27 Jan 2020 14:50:04 GMT

TMEM184B is a relatively uncharacterized 7-pass transmembrane protein that is a member of the Transporter-Opsin-GPCR (TOG) superfamily of proteins. It was discovered that over-expression of TMEM184B caused a reduction in scratching in response to interleukin-31 (Il-31) exposure. This was surprising given previous studies had shown that knock-out of TMEM184B resulted in a reduction in Il-31 induced scratching. Increasing the activity and/or abundance of TMEM184B in a patient may be used to treat itch. Background: Chronic itch affects up to 15% of the population. It may be ...

Affinity Peptide Conjugated with Antioxidant for Protection of Proteins from Oxidation

JianlingL@tla.arizona.edu — Wed, 22 Jan 2020 14:36:43 GMT

This invention is a targeted peptide conjugated with an antioxidant to inhibit Akt1 nitration. It can be utilized for treating pulmonary arterial hypertension (PAH) with potential application in other abnormal proliferative disorders such as cancer. Background: Pulmonary arterial hypertension (PAH) is a disorder affecting 1.1 to 17.6 million adults per year with a prevalence of 6.6 to 26 million. This progressive disorder is characterized by angioproliferative vasculopathy in the pulmonary arterioles leading to endothelial and smooth muscle proliferation, dysfunction, inflammation an...

Blown Float Glass Lens Array and Method

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 14:11:22 GMT

This technology is a method for shaping glass that is used in silicon PV panels. The method involves a floating liquid glass that is used to form a flat sheet and is then blown to fit the curve of the shape. Sophisticated shaping control yields surfaces that may be used for a variety of solar panel applications, including concentrated photovoltaic systems in which lenses focus solar power on higher efficiency solar cells for improved performance. Background: With the increase in the demand for renewable energy and push for solar panels, there has been a significant decrease as ...

Dual-Axis Tracker Using Lightweight Spaceframe Structures

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 14:09:28 GMT

This technology is a dual-axis tracker that is used in combination with a dish reflector to be used within a heliostat. The technology uses an azimuth structure that allows free vertical motion up and down the rotation axis and a full rotational motion about the axis. Background: Heliostats are commonly used within renewable energy and solar products. They are used to direct sunlight towards a predetermined target. This can allow solar products to be more effective and efficient when converting solar energy. Currently, there are a variety of heliostat products that can be purch...

Optical Gyroscope with Gain Medium and Circulating Light

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 13:48:59 GMT

This technology is a novel design for a gyroscope, which uses a central component that contains an optical whispering gallery arrangement, comprising a small sphere with one index of refraction, embedded in a larger sphere with a different index of refraction. Unlike other gyroscopes, which use bidirectional light, this design uses unidirectional light and employs polarization for enhanced sensitivity. Background: Gyroscopes have long been used to sense angular velocity changes, but traditional mechanical, vibrational, or optical gyroscopes tend to be larger than desired for integra...

Polishing Interface Coating Technology

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 13:41:59 GMT

This invention is a method of adhering pitch to a polishing lap that utilizes a non-Newtonian fluid. This advancement enhances the smoothing capabilities for a previously developed polishing tool or similar tools that use a non-Newtonian fluid. Background: Manufacturing of lenses requires expensive machinery including high precision grinding and polishing machines. There is a need for advanced polishing laps to optimize the quality and quantity of high-grade lenses. Optical products are rigorously tested and only the highest-grade lenses end up as finished products. T...

Bifacial Spectrum Splitting Photovoltaic Module

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 13:39:06 GMT

This invention is a system that combines different methods of increasing photovoltaic energy output and overall efficiency. Each of the methods increase the output and when combined have the potential to significantly increase the output and module efficiency (up to 55.78% estimated increased energy yields compared to the standard common PV cells) without significantly increasing the manufacturing costs. The increased energy yields could lead to systems with lower LCOE (levelized cost of energy). Background: Renewable energies address the rising concerns about the sustainabilit...

Optomechanical Inertial Reference For Atom Interferometers

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 13:37:45 GMT

This invention is a combination of two devices meant to increase the performance and accuracy of measurements gathered surrounding small-scale matter. It involves the use of a highly sensitive and compact optomechanical inertial sensor that is capable of both testing mass and acting as an inertial reference of atom interferometers simultaneously. These technologies are easily adapted to work together, avoiding entire redesign and new technology costs associated with a brand-new device. It also enhances performance, robustness and deployment capabilities for atom interferometric based ine...

Aberration Correction in Volume Holographic Optical Elements using Spatial Light Modulator Computer Generated Holograms

JianlingL@tla.arizona.edu — Wed, 18 Dec 2019 13:32:56 GMT

This invention is a proprietary approach to realizing a reconfigurable computer generated hologram. This approach uses a spatial light modulator (SLM) to form a wavefront to correct for wavelength shift induced aberrations in volume holographic focusing elements. Background: Volume holographic optical elements show great potential for use in constrained applications like augmented and virtual reality eyewear since they can be realized with high diffraction efficiency in thin film materials. However, one of the problems with volume holographic materials is that they are only sen...

Modulators of Melanocortin Receptors for the Treatment of Depression and Anxiety

JianlingL@tla.arizona.edu — Fri, 13 Dec 2019 09:14:45 GMT

This invention is the use of the melanocortin 5 receptor (MC5R) ligand to treat depressive and anxiety disorders. MC5R antagonism is the proposed mechanism of action. Background: Depression and anxiety often have similar treatment, but experiencing the full effects of current pharmacotherapy can range from weeks to months. Antidepressants and anxiolytics are associated with a number of side effects including an increased risk of suicidal thoughts in those taking antidepressants. Therefore, a novel pathway is needed for rapid onset with minimal side effects. Application...

Method for the Treatment of Depression and Anxiety

JianlingL@tla.arizona.edu — Fri, 13 Dec 2019 09:14:24 GMT

This technology relates to a modified version of SHU9119, a peptide chain that is known to interact with Melanocortin. This modified version of SHU9119 can antagonize the Melanocortin 5 Receptor (MC5R), potentially enabling rapidly-acting drugs to target these receptors and provide therapeutic relief for those suffering from depression and other mood disorders. Background: Current treatments for depression include drugs with delayed therapeutic onset. This technology has the potential to fill this unmet need with a therapy that is specific to MC5R for treating depression ...

Methods for the Treatment of Central Nervous System (CNS) Disorders and Mood Disorders

JianlingL@tla.arizona.edu — Fri, 13 Dec 2019 09:14:09 GMT

This technology is a modified version of SHU9119, a peptide chain that is known to interact with Melanocortin Receptors. This modified version of SHU9119 can antagonize a Melanocortin 5 Receptor, allowing rapidly acting drugs to target these receptors and provide therapeutic relief for those suffering from depression and other mood disorders. Background: Current treatments for depression include drugs with delayed therapeutic onset. This technology has the potential to alleviating depression and other moods disorders in a shorter time period. Applications: Pharmaceutical ...

Novel Modulators of Melanocortin Receptors for the Treatment of Depression and Anxiety

JianlingL@tla.arizona.edu — Fri, 13 Dec 2019 09:13:53 GMT

This technology describes a cyclic peptide modification that allows for antagonistic binding toward melanocortin 5 receptor (MC5R). Evidence links this receptor to depression and mood disorders, allowing the invention to effectively treat certain mental disorders. Background: SHU9119 is a peptide chain that is known to interact with melanocortin receptors. The receptors themselves are a series of five receptors that are difficult to isolate for targeted drug therapy. The invention relates to a modified version of SHU9119 that can antagonize MC5R and rend it inert to further che...

Method for the Treatment of Depression

JianlingL@tla.arizona.edu — Fri, 13 Dec 2019 09:13:23 GMT

This invention involves utilizing a composition, PG-20N, to treat depression or anxiety. It is specifically designed to treat conditions with a selective melanocortin 5 (MC5R) antagonist. Melanocortins exert many biological activities in the brain including control of feeding, grooming, hyperalgesia, social and sexual behaviors, central regulation of inflammation, fever, and cardiovascular functions, as well as neurotrophic activities. Background: Depression and anxiety contribute significantly to death and disability worldwide, and they frequently occur together. While industry sta...

New Class of Mosquitocide

JianlingL@tla.arizona.edu — Fri, 13 Dec 2019 09:00:37 GMT

This invention is a small molecule mosquitocide and method of mosquito control is based on selectively inhibiting the blood feeding of female mosquitoes. The compound inhibits nutrient processing and is lethal as shown in adult mosquito assays. Background: Numerous diseases are spread by mosquitoes, which develop resistance to chemical pesticides over time. New modes of actions for vector control are needed to combat numerous serious diseases. Advantages: Targets blood feeding female mosquitoes using biochemistry Does not work by neurotoxicity The mode ...

Hybrid Filament Creation for 3D Printing of Resorbable Bone Scaffolds

JianlingL@tla.arizona.edu — Wed, 04 Dec 2019 13:35:20 GMT

This invention describes composite filaments for fused deposition modeling (FDM) 3D printing, and the methods of their production. This novel blends of filaments have better properties for 3D printing bone scaffolds with improved degradation kinetics and functionalities. Background: Due to an aging global population, the incidence of musculoskeletal disorders is increasing. Today, small volumes of bone or bone-like materials are commonly used in a variety of treatments to help heal or fuse a patient’s bones as necessary. These bone grafts are generally autografts (bone sourced ...

Stable Nanodroplet for Medical Imaging

JianlingL@tla.arizona.edu — Wed, 04 Dec 2019 13:24:28 GMT

This technology improves on current nanodroplet technology that can be activated through ultrasound to form microbubbles for imaging or drug delivery. These novel nanodroplets have layers at the exterior shell making the droplets more thermally stable and capable of circulating in the body longer. The nanodroplets have unaffected ultrasound activation profiles that do not require higher ultrasound frequencies. Background: Ultrasound imaging, also known as sonography, uses high-frequency sound waves to visualize the interior of the body. Ultrasound images can show movement ...

Disrupting Mosquito Eggshell Formation by Targeting A Highly Diverged Biological Pathway

JianlingL@tla.arizona.edu — Wed, 06 Nov 2019 13:33:12 GMT

This technology is a new method to control mosquito populations by disrupting mosquito-specific proteins important for embryonic development. Based on a bioinformatics study, a mosquito-specific regulatory protein, Eggshell Organizing Factor 1 (EOF1), was discovered, which is highly diverged from other species. EOF1 controls the synthesis of eggshell proteins from mosquito follicular epithelial cells. Experiments on mosquitos demonstrated that disrupting the biology of this eggshell formation pathway in the female mosquito after a blood meal results in non-viable eggs. ...

Methods for Practical Synthesis of Deuterated Aldehydes

JianlingL@tla.arizona.edu — Wed, 06 Nov 2019 08:02:36 GMT

This technology is an organocatalytic strategy that enables directly converting readily accessible aldehydes to their 1-deutero counterparts. The approach is distinct from the reported transition metal catalyzed ionic hydrogen-deuterium exchange (HDE) processes. The power of this new process has not only been demonstrated for aromatic aldehydes, but also for aliphatic substrates, which have been difficult for HDE, and for selective late-stage deuterium incorporation into complex structures with uniformly high deuteration level (>90%). Background: Among isotopes, deuterium has per...

Diagnostic for Monitoring Response to Immunotherapies for Gynecologic Cancer

JianlingL@tla.arizona.edu — Wed, 16 Oct 2019 15:37:43 GMT

This invention is a collection of immunological checkpoint proteins and physiological markers to diagnose and potentially monitor treatments for cervical cancer. This biomarker panel would be taken using the cervicovaginal lavage method, which is less invasive than other sampling methods for cervical cancer. This diagnostic test could be used not only for diagnosing cervical cancer, but also monitoring a patient's response to immunotherapy. It could also be utilized in precision medicine to determine which immunotherapeutic regimen would be the most effective for a particular individual.&...

Arizona Illustrated: Marching for their Lives

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:59:53 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Marching For Their Lives."      Background: Emmy® award-nominated segment - The survivors of the February 14, 2018 shooting at Marjory Stoneman Douglas High School in Parkland, Florida sparked the Never Again movement with their outrage. Now their call to action is inspiring young people across the country - including students in Tucson, Arizona.

Arizona Illustrated: Zaira

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:59:36 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Zaira."      Background: Emmy® award-nominated segment - Tucsonan Zaira Livier believes making the world a better place stays close to home. Her own complicated history influences her work as a human rights advocate and grassroots organizer working to change local polices around immigrants' rights. But Zaira's story isn't only one of political empowerment; it's also a tale of navigating through great personal tragedy.

Arizona Illustrated: Where Dreams Die

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:59:07 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Where Dreams Die."      Background: Emmy® award-nominated segment - In the 1990s, U.S. Border Patrol implemented policies that increased enforcement in urban areas, leading migrants to cross in remote, dangerous terrain. Since then, more than 3000 human remains have been found in Southern Arizona and thousands of people are missing. Local artist Alvaro Enciso has made it his goal to remember and honor the lives of the migrants who have died in the Sonoran Desert. Every we...

Arizona Illustrated: When Sarah Runs

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:58:49 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "When Sarah Runs."      Background: Emmy® award-winning segment - 27-year-old Tucson-based nurse and distance runner Sarah Sellers trains every day, but unlike many runners who dominate the big races, she wasn't a professional runner until recently. She had only run one marathon when she entered the best-known race in the country - and placed second in the Boston Marathon earlier this year.

Arizona Illustrated: The New Brian

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:58:29 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "The New Brian."      Background: Emmy® award-nominated segment - On February 28, 2015, Brian McGinn had a hemorrhagic stroke that nearly took his life. Before that day, Brian was a gifted guitarist, a woodworker, and a teacher in the Tucson Unified School District for 23 years. After it, he became a man on a mission. He and his wife Julie embarked on a journey to find the "new" Brian - a journey that would lead them to discover new friends, new goals, and a new ...

Arizona Illustrated: The Loop

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:58:12 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "The Loop."      Background: Emmy® award-nominated segment - On March 17, 2018 Pima County celebrated the completion of the "The Loop" - a system of more than 100 miles of paved pathways that runs in Tucson, Marana, Oro Valley, South Tucson and unincorporated Pima County. It began after the historic floods of 1983 as a way of building banks to try to prevent future catastrophic floods so the recreational component was added which serves pedestrians, bicyclists an...

Arizona Illustrated: Sean Parker's Universe

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:57:53 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Sean Parker's Universe."      Background: Emmy® award-nominated segment - In less than seven years, Tucsonan Sean Parker went from novice to internationally celebrated photographer and cinematographer. He now has an online audience of over 600,000 followers. His fascination with photography has taken him all over the globe, from Iceland to Australia, working with some of the most recognizable media companies and brands in the world.

Arizona Illustrated: Rainer

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:57:35 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Rainer."     Background: Emmy® award-nominated segment - If you had to map the lineage of Tucson's music scene, many roads would lead you back more than two decades to Rainer Ptacek. Born in Eastern Germany in the grips of the Cold War, Rainer and his family emigrated to Chicago in 1956. It was there that he first heard the blues - a musical sound that influenced his entire career. Rainer died 21 years ago, but his legacy lives on in Tucson's music and beyond.

Arizona Illustrated: Lerua's

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:57:17 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Lerua's."      Background: Emmy® award-nominated segment - For more than 30 years, the most common question at the beloved Tucson Mexican restaurant Lerua's (other than 'Can I take your order') has been: 'When are you closing?' The restaurant is located in the epicenter of the planned project to widen Broadway Boulevard, so owner Michael Hultquist has known since the 1980s his building would be demolished, but he didn't have an answer for...

Arizona Illustrated: Ellen and Laci

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:56:58 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Ellen and Laci."      Background: Emmy® award-nominated segment - "She failed at agility and she failed at obedience, but she's a great therapy dog." That's the statement from Ellen Morell, a former dental hygienist, planned giving consultant and current ordained Episcopal priest who now works at Harmony Hospice in Tucson. Eight years ago, Morell obtained a bulldog puppy named Laci and they've become great friends. Together, they've become a popu...

Arizona Illustrated: Chef Kumi

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:56:42 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Chef Kumi."      Background: Emmy® award-nominated segment that focuses on Tucson-bred, Portland-based chef Kusuma (Kumi) Rao. When she announces she's hosting one of her pop-up dinners, it's best to RSVP immediately. Although she hasn't lived here in years, Kumi has so many dedicated Tucson disciples, it's hard for newcomers to elbow a spot at the table. Kumi calls her company Ruchikala, The Art of Taste, and most people who've tasted her food pr...

Arizona Illustrated: Brian Smith

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:55:27 GMT

This is a segment of the Arizona Public Media original program Arizona Illustrated entitled "Brian Smith."      Background: Emmy® award-nominated segment that focuses on the seemingly many lives of Tucson Weekly columnist Brian Smith, traveling one path and then another. He was a nationally-ranked cyclist as a kid. He was the lead singer of The Pills, the Beat Angles, and Gentlemen After Dark, before becoming a full-time writer. After stints as a writer and editor at the Phoenix New Times and Detroit's Metro Times, he came back to Tucson, where he was born. H...

Arizona 360: Immigration Surge

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:55:10 GMT

This is a segment of the Arizona Public Media original program Arizona 360 entitled "Immigration Surge."      Background: Emmy® award-nominated segment that focuses on influx of families crossing the border illegally in the Yuma sector as well as asylum seekers camped outside the port of entry in San Luis, Mexico.

Arizona 360: El Paso Road Show

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:54:53 GMT

This is a segment of the Arizona Public Media original program Arizona 360 entitled "El Paso Road Show."      Background: Emmy® award-winning segment in which Arizona 360 travels to El Paso, Texas where the Trump campaign hosted a rally for border security. Along the way, Lorraine Rivera visits community members, business owners and law enforcement in Southeastern Arizona, New Mexico and Texas to see how they interpret rhetoric from Washington, D.C. about a crisis at the southern border, and what solutions they believe would improve border security.

Arizona 360: Border Crime and Infrastructure

JianlingL@tla.arizona.edu — Tue, 15 Oct 2019 14:54:35 GMT

This is a segment of the Arizona Public Media original program Arizona 360 entitled "Border Crime and Infrastructure."      Background: Emmy® award-nominated segment that focuses on Nogales concertina wire; border wall fund raising; immigrant crime rates; and "angel parents" whose children were killed by illegal immigrants.

Constitutions Toolbox

JianlingL@tla.arizona.edu — Wed, 09 Oct 2019 16:29:50 GMT

The Constitution Toolbox consists of copyrighted material including (images, video, text, reports, case studies, lectures, interviews, reports and apps) related to Native Nations governance. That content has been organized into Guides & Manuals, Nations in Action, Research on What Works, In Their Own Words, Samples & Examples, Resources for Teachers, and Helpful Links at website: https://sites.google.com/g.harvard.edu/constitutionstoolbox/constitutions?authuser=0

Alkali Metal Doped Graphene as Solid Hydrogen Storage System

JianlingL@tla.arizona.edu — Thu, 26 Sep 2019 14:06:47 GMT

University of Arizona researchers have developed an alkali metal ion doped graphene that is used as a material for a hydrogen storage system. Background: The majority of currently commercially available materials used for storage systems are metal. Using metal causes the system to be heavy and have a low gravimetric density. Other materials require extreme temperature and pressure conditions to control the hydrogen adsorption and desorption process. Hybrid materials require chemical or mechanical activation at a high temperature. These materials and their drawbacks are why the materi...

White Light Interferometry Imager

JianlingL@tla.arizona.edu — Thu, 26 Sep 2019 14:02:12 GMT

This technology is an extended depth of field (EDOF) system that maintains high lateral resolution while extending the depth of field. It is based on white light interferometry but adds a feature where the interferometer scans through the different depths of an object to create a depth map. Background: White light interferometry offers a solution to the age-old trade-off in optics between depth of field and lateral field of view. Using white light interferometry, contrast fringes in interference images appear near zero optical path difference and best focus. By scanning through a ra...

On-Chip CMOS Threshold Processing

JianlingL@tla.arizona.edu — Thu, 26 Sep 2019 14:01:27 GMT

This technology is a method of processing the interference fringes produced by the UA19-178 system. It employs a threshold-type operation at the incoherent light level so that only constructive interference is recorded, which greatly speeds up the data processing by reducing the amount of data to process in the first place. Processing occurs on the sensor to manipulate the raw signal into the desired form. The sensor’s circuit elements transform the data from each pixel without sending the signal off-chip, thus avoiding the bottleneck effect that occurs from serially tran...

Digital Illumination Assisted Gaze Tracking

JianlingL@tla.arizona.edu — Thu, 26 Sep 2019 13:58:55 GMT

This invention describes a better design for a wavefront sensor that can capture all the desirable traits of a wavefront sensor in one package. It takes the best attributes of the two most well known wavefront sensors (Shack-Hartmann type and Pyramid type). Alone, these two wavefront sensors can only achieve 1-2 of the three ideal wavefront sensor properties: high sensitivity, wide dynamic range, and linearity. This novel wavefront sensor allows for all three properties to be realized in single sensor design. Background: Wavefront sensors are at the forefront of adaptive optics, a f...

Essential Oil Microemulsions and Plant Extracts to Prevent Biofilm Formation

JianlingL@tla.arizona.edu — Wed, 18 Sep 2019 14:38:50 GMT

This technology surrounds the usage of plant extract microemulsions for the prevention of biofilm formation on food contact surfaces and medical devices. These microemulsions are non-toxic, plant-based, and are effective against known biofilm-forming pathogens such as Salmonella sp., E. coli, and Listeria monocytogenes. This invention presents a safe and natural way to prevent the formation of biofilms, thereby reducing the risk of contamination of ready-to-eat food products and potentially medical devices. Background: The term “biofilm” refers to a colony of prokaryotic...

In the Americas with David Yetman Series Season IV

JianlingL@tla.arizona.edu — Wed, 18 Sep 2019 13:21:12 GMT

Arizona Public Media is the presenting station for In The Americas with David Yetman, an initiative of The Southwest Center, The University of Arizona. This series takes a fresh look at the lands that make up much of the Western Hemisphere. Each country contains landscapes, peoples, and history that have not received the attention they deserve on the world stage.      Background: Several Season IV episodes focus on diverse topical areas in Central and South America.

Automated Conversion of Corrosion Current to Corrosion Rate

JianlingL@tla.arizona.edu — Tue, 17 Sep 2019 15:48:13 GMT

This invention is an automated program to be used to convert corrosion data derived from polarization (current vs. voltage) curves to corrosion rates in units of micron per year. The automated analysis calculates corrosion rates in an unambiguous and automatic way. It is less time-consuming and arbitrary than the conventional graphical analysis used currently. The data analysis is used in an automated test station which is currently being developed at the Water Energy Sustainable Technology (WEST) center in Tucson, Arizona. The data is of primary interest for converting electrochemical (I/V) ...

Variable Solvent Polarity Chromatography

JianlingL@tla.arizona.edu — Tue, 17 Sep 2019 14:11:14 GMT

In this invention, an external stimulus is applied to the stationary phase of liquid chromatography to alter the polarity of the solvent during a separation process. This capability enables improved separations with more efficient use of mobile phase. The chromatographic separation method can be designed with flexible equipment and machine learning. Background: Chromatography is a well-established process and is widely used for laboratory chemical separation; however, it is problematic for large scale use. Enhancements in separation efficiency will be use...

Variable Stationary Phase Chromatography

JianlingL@tla.arizona.edu — Tue, 17 Sep 2019 14:06:59 GMT

In this invention, an external stimulus is applied to the stationary phase of chromatography to alter the polarity of the stationary phase during a separation process. This capability enables improved separations with more efficient use of mobile phase. The chromatographic separation method can be designed with flexible equipment and machine learning. Background: Chromatography is a well-established process and is widely used for laboratory chemical separation; however, it is problematic for large scale use. Enhancements in separation efficiency will be u...

The i-Abacus Green Box

JianlingL@tla.arizona.edu — Thu, 12 Sep 2019 16:55:34 GMT

Invention: University of Arizona researchers have invented a modular cultivation system that is designed to be used in a vertical farm or plant factory. The box has an expandable and collapsible support frame and growing pods, which contribute to a unique end product. It is amenable to automation and remote control. This product can be used in a warehouse or greenhouse type of vertical farm/plant factory. The dimensions of the product can be adjusted to fit the entire available volume of space being used. Background: As urban populations continue to increase and more people become ...

The i-Sprout Green Box

JianlingL@tla.arizona.edu — Thu, 12 Sep 2019 16:55:08 GMT

Invention: University of Arizona researchers have invented an expandable and collapsible modular cultivation system intended for use in vertical farming or plant factories. It includes the capability to expand or retract in size to fit any volume or spacing restrictions, which efficiently maximizes crop productivity. Background: In an effort to reduce the amount of water and land used to cultivate crops, many farms have resorted to vertical farming and plant factory methods. These methods have shown to effectively produce crops with 97% less water than traditional farming arrangem...

The i-Incline Green Box

JianlingL@tla.arizona.edu — Thu, 12 Sep 2019 16:53:32 GMT

Invention: University of Arizona researchers have invented an expandable/collapsible modular system for use in vertical farms. The angle-adjustable growing boards help to expand/collapse the system, allowing for flexible maneuverability and high crop yield. Background: Considered by many to be the next stage in the evolution of agricultural production, vertical farming has become the next generation method to produce crops in an indoor environment. The industry standards utilize tower-like designs inside climate-controlled facilities to achieve greater crop yields than conventional...

Continuous-Feed Solid-State Fermentation Module For Mushroom Production

JianlingL@tla.arizona.edu — Wed, 11 Sep 2019 15:17:18 GMT

This technology is a continuous-feed solid state fermentation system to extend the effective commercial mushroom production cycle. Mushrooms can be cultured for food, fuel, and pharmaceuticals. Background: Current culturing of mushrooms consist of liquid or submerged fermentation. Mushrooms are also grown in solid-state fermentation in a single-feed process. Though with this process after the mushroom is produced the nutrients are depleted. When cultivating mushrooms there are a variety of issues that can occur that can affect the quality and outcome of the mushrooms. Some of t...

A Molecular Diagnostic Tool for Detecting Clostridium difficile Infection, Carriage and Outbreaks

JianlingL@tla.arizona.edu — Wed, 11 Sep 2019 14:44:50 GMT

This invention is an extremely sensitive and precise molecular diagnostic tool to accurately identify clostridium difficile strains. Background: Clostridium difficile is a healthcare associated infection with significant patient mortality, morbidity, and may result in prolonged hospital stays. It is the leading cause of healthcare-associated infections and represents a substantial healthcare cost burden. Rapid and early identification of toxigenic Clostridium difficile (C. difficile) is important to the early and appropriate management and implementation of infection control measures...

Phymatotrichopsis Root Rot Management in Alfalfa

JianlingL@tla.arizona.edu — Wed, 11 Sep 2019 14:31:17 GMT

This invention involves the feasibility of managing Phymatotrichopsis root rot. Background: In the low desert Arizona, alfalfa grown on calcareous alkaline soil suffer sever stand damage and substantial yield loss due to Phymatotrichopsis root rot caused by Phymatotrichopsis omnivore. Applications: Alfalfa management Fungicide application Advantages: Potential improved yield Cost effective application rates

Pharmacological Cognitive Protection of Bees Against Neuropesticides

JianlingL@tla.arizona.edu — Fri, 06 Sep 2019 17:01:06 GMT

This technology is compositions and methods for protecting insect pollinators against the harmful cognitive effects of pesticides. It is suitable for ingestion by an insect pollinator and protects against pesticide-induced impairment of a cognitive function of the insect pollinator. Methods of using such compositions to prevent or reduce pesticide-induced impairment of cognitive functions, which include learning, memory, decision-making and navigation, protect insect pollinators such as honeybees and bumblebees against neurotoxic pesticides, including neonicotinoids such as Imidacloprid. &nb...

TomCats (Tomato Caterpillars)

JianlingL@tla.arizona.edu — Thu, 05 Sep 2019 15:54:36 GMT

This invention is the production of protein-rich caterpillars. Background: Population growth and increasing standards of living require significantly greater food production. Animal protein sources demand high-intensity uses of land, water, and energy. In many cultures insects are traditionally served as an alternative protein source. These sustainably provide the required protein and nutrients with far less impact. This complementary process uses minimal resources while providing a valuable alternative protein source. Applications: Sustainably-minded grocers Huma...

Rearing Mealworms on Beer and Vegetable Waste in a Self-Contained System

JianlingL@tla.arizona.edu — Thu, 05 Sep 2019 15:12:07 GMT

This invention is a sustainable and waste-free system for farming mealworms as a protein source for human consumption. Background: Environmental efforts have created a demand for an alternative protein source for human consumption. Beef, pork, and chicken protein produce a significant amount of greenhouse gas, there is a need for a complete protein source that provides the same nutrients, that is cheaper to produce and has a lower environmental impact. Insects have been consumed regularly elsewhere for millennia, and over one fourth of the world’s population consumes bugs...

Passive, Solar, Large-Scale Drying System For Agricultural Waste

JianlingL@tla.arizona.edu — Thu, 05 Sep 2019 13:55:38 GMT

This invention is a large-scale passive solar system for drying large quantities of agricultural waste. Background: Environmental efforts have created a demand for an alternative protein source for human consumption. As beef, pork, and chicken protein produces a significant amount of greenhouse gas, there is a need for a complete protein source that provides the same nutrients, that is cheaper to produce and has a lower environmental impact. Insects have been consumed regularly elsewhere for millennia, and over one fourth of the world’s population consumes bugs in t...

A Fast Compression Algorithm For Images And Video Capable Of Real-Time Speed

JianlingL@tla.arizona.edu — Wed, 04 Sep 2019 15:17:33 GMT

This technology is an algorithm that provides real-time, high performance, “lossless” data compression. Background: Data compression algorithms, such as a zip file, reduce the number of bits needed to store or transmit digital information. The performance of the algorithms is often quantified in terms of a compression ratio. For example, 80% means that the compressed data would use 80% fewer bits than the original. The highest performance algorithms, such as those used to compress video for consumer applications (i.e. an mp4 video file) are “lossy,”...

GL261-luc2 Model

JianlingL@tla.arizona.edu — Tue, 03 Sep 2019 12:51:24 GMT

GL261 (mouse glioma 261) is an in vivo model system used to study glioblastoma multiforme (GBM). This technology is the GL261 cell line stably transfected with the luc2 gene (GL261-luc2) for the monitoring of intracranial mouse tumors. GL261-luc2 is a brighter version than the original GL261-luc line. Relevant Paper: Abdelwahab MG, Sankar T, Preul MC, Scheck AC. Intracranial Implantation with Subsequent In Vivo Bioluminescent Imaging of Murine Gliomas. J. Vis. Exp. (57), e3403, DOI: 10.3791/3403, 2011.

Phyto-Mediated Wastewater Treatment Bioreactor (PWBR)

JianlingL@tla.arizona.edu — Thu, 29 Aug 2019 06:12:34 GMT

The Phyto-Mediated Wastewater Treatment Bioreactor (PWBR) is a process for treating various types of wastewater through removal of contaminants, including residual forms of Nitrogen, Phosphorus, heavy metals, etc. The PWBR can also remove Contaminants of Emerging Concern (CEC's) which include, but are not limited to, pesticides, pharmaceuticals, personal care products, polycyclic aromatic hydrocarbons, perfluorinated compounds and engineered nanomaterials. PWBR is superior to industry alternatives due to the modularity and portability of the treatment system and its ability to target spec...

Nematicidal Activity of three Secondary metabolites produced by the Entomopatogenic Bacteium Photorhabdus l. sonorensis

JianlingL@tla.arizona.edu — Thu, 29 Aug 2019 06:02:28 GMT

University of Arizona researchers have discovered secondary metabolites that were isolated from P. l. sonorensis bacteria with potential use in nematicides. This technology has the potential to control plant parasitic nematodes effectively, while still being safe and following environmental regulations. In particular, this technology involves the use of biologically active secondary metabolites from insect pathogenic Photorhabdus bacteria, which have antibacterial antifungal, insecticidal and nematicidal properties, including properties against the root knot nematode. Background: Ne...

Arizona Illustrated: Halfway Home

JianlingL@tla.arizona.edu — Thu, 22 Aug 2019 08:14:19 GMT

This is an episode of Arizona Public Media's original newsmagazine program Arizona Illustrated entitled "Halfway Home."  Background: This original video production addresses the uphill battle that the more than 650,000 Americans released from prison each year face when they transition to civilian life, including barriers to employment and housing.

Navajo Interpreter Certification Examinations

JianlingL@tla.arizona.edu — Thu, 22 Aug 2019 08:08:07 GMT

The Navajo Interpreter Certification Examinations include a two-part testing process, both designed to assess essential knowledge, skills, and abilities of interpreters who work in Navajo and English. Background: The first part ("Test of English Proficiency") is a multiple-choice test specifically designed to assess the English proficiency of potential Navajo interpreters. Passage of this test is a prerequisite for the second part of the testing process. The second part ("Navajo Interpreter Performance Test") assesses a candidate's abil...

Navajo Interpreter Training Program

JianlingL@tla.arizona.edu — Thu, 22 Aug 2019 08:01:27 GMT

The Navajo Interpreter Training Program is a 50-hour curriculum designed to introduce aspiring and working Navajo interpreters to best practices in the field of court interpretation. Background: The curriculum includes introduction to interpreter ethics and interpreting techniques for three different interpreting modes. Additionally, it covers special topics such as legal procedure, anatomy and physiology, firearms, sexual assault, and other topics that arise in state courts. It also includes written and audio interpreting lab practice materials.     

Dietary Manipulation of the Oxytocin and Vasopressin Systems in Domestic Dogs

JianlingL@tla.arizona.edu — Wed, 21 Aug 2019 14:47:54 GMT

This invention is a dietary supplement for use in domestic dogs that is capable of improving social behavior and emotional states. Applications: Animal shelters Veterinary medications Animal dietary supplements Advantages: Improves memory and cognition Reduces aggression and anxiety Promotes heart health Weight loss Reduction in blood pressure Improves skin and hair growth Increases bonding

The V-Hive Green Box

JianlingL@tla.arizona.edu — Mon, 19 Aug 2019 10:28:00 GMT

Invention: University of Arizona researchers have developed an invention that maximizes plant cultivation efficiency through vertical modular units. Background: Concerns about excessive land use and a desire for locally-grown food present an opportunity for innovative solutions. Indoor farming allows greater control of variables to optimize processes and grow food that may be unsuited for ambient conditions. The Vertical-Hive Green Box (V-Hive Green Box) effectively applies these concepts in a vertical modular system. This complements existing practices and incorporates available s...

Engineering High Protein Content Soybeans

JianlingL@tla.arizona.edu — Thu, 15 Aug 2019 16:28:29 GMT

This invention is an enabling technology to create enhanced value soybean seeds with higher proportional seed protein content. Background: Soybeans are the primary global source of plant-source protein. About 70% of the global protein input for animal feed is obtained from soybean. The soybean industry has a strategic goal of increasing seed protein content while preserving maximum oil content. Soybean seed protein content is regulated by genotype and can be bred as a trait, however, protein composition is far more plastic, termed proteome rebalancing, and can be significantly altere...

Health Behavior Change for Prediabetes

JianlingL@tla.arizona.edu — Thu, 15 Aug 2019 16:17:45 GMT

This Family Consultation (FAMCOM) for Prediabetes Program is a health behavior change program for use with adult couples in which at least one member is prediabetic. FAMCOM is an evidenced-based treatment that is effective in modifying a range of health behaviors and has been adapted for prediabetes. The program uses systemic perspective to target couple-level interaction patters to promote increased physical activity and healthier eating. Background: Health behaviors occur in a social context, and to affect long-term, sustainable health behavior chan...

LIDAR Operating Software for Precise Measurements

JianlingL@tla.arizona.edu — Wed, 14 Aug 2019 16:07:05 GMT

This product is a Light Detection and Ranging (LIDAR) attachment for any compatible drone that will have the ability to make 3-dimensional maps at a high resolution. It is a very low-cost product compared to others on the market. The data points are given in LAS format and are passed through an algorithm using a ground-up perspective to analyze the objects with high accuracy. Background: Resolution requirements make it quite challenging for drones to maintain the flight duration needed to create a high-resolution map. Edge of the LIDAR path has less dense point data than at the cent...

A Fault Tolerant and Power Efficient Network-on-Chip Architecture using Quad-Function Channel (QFC) Buffers

JianlingL@tla.arizona.edu — Wed, 14 Aug 2019 15:51:37 GMT

QORE is a fault tolerant Different Network on Chip (NoCs) that seeks to reduce power consumption and improve performance of NoCs while mitigating errors caused by faults. Through a new type of data buffer and connecting multiple processing cores QORE has the ability to reduce power and avoid faults. Background: With electrical components shrinking in size, there has been remarkable growth in the number of cores that can be integrated within a single chip multiprocessor. As the number of cores continue to scale and conventional on-chip communications approach their limits, architects are ur...

National Clinical Assessment Tool in Emergency Medicine and Web-Portal

JianlingL@tla.arizona.edu — Tue, 13 Aug 2019 08:07:36 GMT

This is an assessment form (shift card) for medical students performing their emergency medical clinical rotation. It was created via a national consensus conference and is known as NCAT-EM.  The tool is designed to measure medical students’ clinical performance during a single shift, typically lasting 8-12 hours. An associated web portal was created by Johns Hopkins where site directors input de-identified demographic and assessment data for review.  Contributors to this technology are from multiple institutions.      Background: Despite differences in prior experience,...

Copolymerization of Elemental Sulfur and Functional Styrenics

JianlingL@tla.arizona.edu — Wed, 31 Jul 2019 16:00:01 GMT

This invention relates to polymeric compositions. In particular, the attractive chemical accessibility and functional diversity of styrenic comonomers used with elemental sulfur to prepare a new chemical platform for sulfur-based polymeric materials and to further enable post-polymerization modifications for improving the properties of sulfur-based materials. Background: An incredible abundance of elemental sulfur, nearly 7-million tons is generated as a waste byproduct from hydrodesulfurization of crude petroleum feedstocks, which converts alkanethiols and other (organo) su...

Conjugation of the MCR1 Ligand with Cytotoxic Drugs for Targeted Melanoma Therapy

JianlingL@tla.arizona.edu — Mon, 22 Jul 2019 08:35:39 GMT

University of Arizona researchers have developed a drug composition and method of cancer treatment using chemotherapeutics linked to ligands selective for uptake by melanocortin 1 receptors (MC1R) in MC1R-overexpressing melanoma. This development targets melanoma, and may be used with a wide range of cytotoxic drugs, to selectively deliver a toxic payload that may be less likely to result in melanoma treatment resistance and off-target effects of systemic exposure. Background: Melanoma is the most deadly form of skin cancer in the United States, with an estimated 87,110 new cases an...

Resident Evaluation System Application (RES App)

JianlingL@tla.arizona.edu — Mon, 22 Jul 2019 07:43:54 GMT

This is an application for students and faculty to access and transmit information related to resident evaluations. It features easy to use competency-based evaluations called EPAs; a notification system used to communicate expectations about the EPAs to the resident in advance of the rotation start; a notification system to assign EPAs to faculty. In addition, standardized evaluation forms from ACGME and ABS can also be communicated to and completed by faculty as requested by the student through the application. The data gathered through the application and is uploaded into the evaluat...

System and Methods For Sleep Optimization

JianlingL@tla.arizona.edu — Fri, 19 Jul 2019 16:32:31 GMT

This invention describes a system and methods for helping an individual determine how much sleep is optimal for them and what time they should go to sleep based on specific outcome or outcomes of interest like mood, work performance, blood pressure, etc. This approach uses an individual's sleep data to help calibrate/optimize their sleep so that they can perform optimally relative to their outcome(s) of interest. Background: Modern societies are facing challenges in achieving adequate sleep and experiencing a variety of sleep disturbances and it is difficult to known how much sle...

3D-Printing of Ultra-High Refractive Index Polymers for Fabrication of Optical Components and Devices

JianlingL@tla.arizona.edu — Thu, 18 Jul 2019 11:05:39 GMT

Through utilization of sulfur based, high refractive index copolymers and 3D printing, this invention seeks to enhance the physical properties and capabilities of optical components and devices. Background: High refractive index polymers (HRIP) are most commonly found in optical oriented devices. These HRIPs offer several significant advancements over older and current technologies in this field like reduced densities, greater strengths, and overall increased performance. Applications: Military (scopes, sights, binoculars, etc.) Medical (x-ray machine manufacturing, mic...

Nucleophilic Activation of Elemental Sulfur with Amines and Nucleophilic Heterocycles

JianlingL@tla.arizona.edu — Thu, 18 Jul 2019 10:50:52 GMT

This invention describes a process to utilize nucleophiles to activate elemental sulfur. Background: Existing catalytic methods involve heavy metal components and ultraviolet light. Alternative options also include using free-radicals to catalyze a polymerization reaction. The invention instead has the benefit of generating intermediates with unexplored reactivity, which can be used to bond compounds into a sulfur copolymer. Applications: Polymeric drug delivery systems Production of lithium sulfur batteries Advantages: Rapid reaction time Cost saving Increased...

Portable Low-Cost System for Field Chemical Analysis

JianlingL@tla.arizona.edu — Thu, 18 Jul 2019 08:33:07 GMT

This invention describes a portable, low cost, system incorporating a compact potentiostat for electrochemical analytical chemistry measurements. The system can run on five-volt batteries and stores data that can be readily exported. Background: Measurement science has continually evolved since the introduction of the operational amplifier, the charges curled device, and the microcontroller. Arduino (computer hardware, software, and microcontroller based kits) provides a cheap means of computing to perform calculations in the field. These have now been brought together in a rev...

Methods For Building A Self-Contained Responsive Biological System

JianlingL@tla.arizona.edu — Mon, 08 Jul 2019 15:18:48 GMT

This technology is a new organ modeling system that utilizes plant leaves to study cancer mechanism and drug interactions. It focuses on the optimized scaffolding of decellularized plant tissues seeded with mammalian cells. The model is ideal for producing a 3D vascularized biological system that can be dynamically controlled through changes in perfusion rate, time-varying changes, and flow-rate. Background: The development of new and effective therapeutics is costly and is often delayed by a lack of adequate models for testing. This technology provides a dynamic 3D biological syste...

Universal Chimeric Antigen Receptors for T-Cell Cancer Therapy

JianlingL@tla.arizona.edu — Fri, 05 Jul 2019 16:25:01 GMT

This invention is a patient-specific "Universal" Chimeric Antigen Receptor T-cell therapy that uses CAR T cells which target a universal "flag", such as a peptide, protein, or small molecule. The "Universal" CAR T cells are linked to "adapter" molecules or particles which have been designed to bind to patient-specific T-cells. Background: Chimeric Antigen Receptor (CAR) T-cell therapy is a form of immunotherapy wherein T-cells are designed to attack cancer cells, currently used most often to treat blood or lymphatic cancers. This process ...

Non-Halogenated Polymer Flame Retardant

JianlingL@tla.arizona.edu — Fri, 05 Jul 2019 16:04:53 GMT

This invention is a flame retardant composition comprising a sulfur copolymer prepared from elemental sulfur using inverse vulcanization. These polymers may be copolymerized with a wide variety of other monomers. When exposed to combustion temperatures, they form high char content, self-extinguishing materials. These polymers may be prepared in blends for application as non halogenated coatings to substrates requiring fire retardant protection. Background: Synthetic polymers are often highly flammable and may not meet fire safety standards on their own. Poly...

Artificial Membranes Incorporating GPCRs for Label-Free, Electrophysiological Measurements of Ligand-GPCR Interactions

JianlingL@tla.arizona.edu — Wed, 03 Jul 2019 13:13:38 GMT

This invention consists of an artificial lipid membrane that incorporates G-protein coupled receptors into its structure. It allows direct, label-free measurement of ligand binding and activation of G-protein coupled receptors. Background: G-protein coupled receptors are a superfamily of proteins that are very popular drug targets. In 2017, 34% of all drugs approved by the US Food and Drug Administration act upon GPCRs, and about 20% of potential drugs in clinical trials target GPCRs. Furthermore, GPCRs are still considered largely untapped targets. In order to screen...

Entanglement-Enhanced Machine Learning

JianlingL@tla.arizona.edu — Thu, 20 Jun 2019 11:54:35 GMT

This invention is a method using quantum entanglement to increase the performance of machine learning. Here, supervised learning is enhanced by an entangled sensor network. This method allows for supervised learning tasks at the physical layer where a quantum advantage is achieved. The entanglement is shared by different sensors which boost the performance of extracting the global features of the object under investigation. This enabling technology offers the potential for ultrasensitive measurements in biological, thermal, and mechanical systems. Background: Current quan...

Integrated Lander Chassis for CubeSats

JianlingL@tla.arizona.edu — Thu, 20 Jun 2019 11:52:23 GMT

This invention is a series of lander designs which are intended for lunar exploration, which would allow CubeSats to expand into being planetary surface explorers. The series of designs transforms a CubeSat into a lander with four legs to optimize space exploration. The four landing legs, each with a foot structure and connected via rotational supports, allow for degrees of freedom for a soft landing. The design and configuration on the legs was developed through trials of structural analysis which determined the occurrences in worst case scenarios. The innovation also has a de...

Self-Adjusting Controllers for Force Assistance Systems in Surgical Robotics

JianlingL@tla.arizona.edu — Thu, 20 Jun 2019 11:47:54 GMT

This technology is a force guidance system for use in human-machine hand-on interfaces like surgical robots. By using sensors, heuristics and motors, the proper force can be applied to the human end to simulate the resistance encountered on the robotic end. This technology employs a novel algorithm that allows the system to tailor the resistance to a user's style and preference for use in training simulators. Background: When surgeons use robotic assist devices it can be difficult for them to gauge the pressure and force necessary to apply to the soft tissue, which can result in...

Howl-itosis: Engineered Bacteria for Dog and Cat Oral Microbiota to Improve Health and Breath

JianlingL@tla.arizona.edu — Wed, 19 Jun 2019 15:03:03 GMT

This invention involves an innovative and easy treatment method to control breath odor in pets by supplementing chew toys and treats with engineered oral bacteria that produce pleasant smelling factors (e.g. wintergreen mint, etc.). Background: Pet’s bad breath is a common problem and it is attributed to bacterial biofilm that forms along the gums, tongue, and teeth. Current treatments for bad breath includes “fresheners” that merely mask the smell temporarily, and dental devices that must be administered by the owner (which can be time consuming to owners and stres...

The Mobile Vertical Farm (Go-Vertical Farm) for Automation of Vertical Farming Operations

JianlingL@tla.arizona.edu — Wed, 19 Jun 2019 15:01:45 GMT

Invention: University of Arizona researchers have developed an original operational process that enables the automation of vertical farming by the use of ambulatory growing modules capable of planting, growing and harvesting under optimal environmental conditions to achieve maximum yield and nutritive value. Background: According to the United Nations, global population will increase from 2019's population of 7.6 billion to approximately 9.7 billion by 2050. United Nations projects that food production will need to increase by 70%. These goals are hard to reach by traditional f...

Obfuscated Dynamic CAPTCHAs

JianlingL@tla.arizona.edu — Wed, 19 Jun 2019 08:56:32 GMT

This invention is a new kind of CAPTCHA, something that tests web applications to determine whether the user is a human. The CAPTCHAs can ask a user to solve dynamic puzzles, i.e. something that changes based on user input, but also the code that executes these CAPTCHAs runs on the client, such as the user’s browser. This means that less work must be done on the server side to ensure that the user is in fact human. Background: CAPTCHA is an acronym for: Completely Automated Public Turing test to tell Computers and Humans Apart. A CAPTCHA is a type of challenge-response system...

A Highly Thermal Stable MRAM Unit

JianlingL@tla.arizona.edu — Tue, 11 Jun 2019 16:26:17 GMT

This invention enables a perpendicular magnetic tunnel junction (pMTJ) device that exhibits high thermal stability when exposed to temperatures greater than 400° C. and even greater than 500° C. for an hour (and sometimes longer). This invention is available for a non-exclusive license and has an issued US Patent 10,431,733. Background: Magnetic tunnel junction (MTJ) structures with perpendicular magnetic anisotropy (PMA) are promising candidates for ultra-low energy memory and logic devices such as spin-transfer torque magnetic random access memories (STT-MRAM). However, for practic...

Voltage-Controlled Magnetic Devices

JianlingL@tla.arizona.edu — Tue, 11 Jun 2019 16:10:25 GMT

This technology enables nonvolatile, reversible control of magnetic anisotropy through voltage induced reversible oxidation. Non-exclusive licenses are available to the resulting US Patent 9,779,865. Background: Using magnetic fields and spin-polarized currents have proven inefficient methods to control the magnetic properties of solids. This invention of voltage induced control provides a more energy efficient approach. Application: Broad scope, with potential for advances the in the fields of: Magnetic random access memory (MRAM) ...

Differential Target Antenna Coupling (DTAC)

JianlingL@tla.arizona.edu — Tue, 11 Jun 2019 15:47:33 GMT

Differential-ATAC Method

JianlingL@tla.arizona.edu — Tue, 11 Jun 2019 15:46:46 GMT

Researchers at the University of Arizona have developed an electromagnetic geophysical system that has significantly improved subsurface target sensing and imaging capabilities compared to conventional subsurface measurement systems such as ground penetrating radar. The Differential Target Antenna Coupling (DTAC) method in a vertical array provides a number of important advantages over the large-offset horizontal array for some applications. Advantages: Can be adapted to rapidly moving measurements, such as from a helicopter The DTAC method is not sensitive to the orientation of ...

Winning by Living: One Cancer Story

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:05:03 GMT

This is an Arizona Public Media original documentary entitled "Winning by Living: One Cancer Story".      Background: This original television documentary chronicles the arduous pancreatic cancer battle of Michelle Kirlew and highlights her experience as she and her family, friends, nurses, and doctors navigate her illness.

Tucson Remembers: The Battle for Europe

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:04:28 GMT

This is an Arizona Public Media original production entitled "Tucson Remembers: The Battle for Europe".      Background: This original television production details Tucson stories from before World War II through V-E Day by those involved in the fight against fascism - including a B-17 ball-turret gunner who had "no place to hide" during aerial combat and a medic who parachuted behind enemy lines on D-Day .

Teachers' Voices

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:04:02 GMT

This is an Arizona Public Media original video production entitled "Teachers' Voices".      Background: This original video production is a special series that highlights the true professionalism of teachers in Southern Arizona. These video testimonials feature classroom teachers translating real world experiences into classroom lessons, and sharing teaching expertise, their passion for education, and stories of student achievement.

Tucson Remembers: War in the Pacific

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:03:38 GMT

This is an Arizona Public Media original production entitled "Tucson Remembers: War in the Pacific".      Background: This original television production details the battle in the Pacific, against a country the size of Montana, raged on tiny islands and from the decks of ships flung across an ocean that covers a third of the earth.

Tucson Remembers: Pearl Harbor

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:03:02 GMT

This is an Arizona Public Media original documentary entitled "Tucson Remembers: Pearl Harbor".      Background: This original television documentary focuses on the day that lives in infamy which changed the lives of hundreds of Tucsonans who went to war. It features gripping accounts from those on the front lines as well as detailing the hardships of life on the home front.

Michelle's Story

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:02:36 GMT

This is an Arizona Public Media original documentary entitled "Michelle's Story".      Background: This original television documentary is a sequel to "Winning By Living: One Cancer Story." The life of Michelle Kirlew, an active and vibrant mom, was turned upside down by pancreatic cancer. It usually strikes people over 70. Michelle was diagnosed at 41. Facing a battle with a form of cancer that kills three of four patients in the first year, she fought. What followed was a whirlwind of appointments, tests, treatments, surg...

Tucson Remembers: The War Years

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:02:16 GMT

This is an Arizona Public Media original production entitled "Tucson Remembers: The War Years".      Background: This original television production provides an encompassing look at Tucson's involvement in World War II at home and abroad. Arizonans describe living through tumultuous times, including hearing the shocking news of the attack on Pearl Harbor, the drudgery of boot camp, and the fear of combat.

Together We Heal

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:01:45 GMT

This is an Arizona Public Media original documentary entitled "Together We Heal".      Background: This original television documentary marks the anniversary of the tragic shooting at a Congress on Your Corner event in Tucson. Together We Heal is a moving and thought-provoking program focusing on emotional healing, both individual and community-wide, over the past year. For many, grieving and healing have become on-going and consequential parts of their lives. Narrated by national correspondent and Tucson native Savannah Guthrie, Together We Heal fe...

Divine Mission: San Xavier del Bac

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:01:23 GMT

This is an Arizona Public Media original television production entitled "Divine Mission: San Xavier del Bac."      Background: This original television production follows the renovation, led by a skilled team of international conservators, of the only standing Mexican Baroque church in the United States. It also features the history of the church and its people as well as an in-depth look at the skills and techniques used in art and historical preservation.

Tucson Remembers: The Korean War

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:00:57 GMT

This is an Arizona Public Media original production entitled "Tucson Remembers: The Korean War".      Background: Korea was the un-won war that never ended. No one even wanted to pronounce it a war: it was "The Korean Conflict," a "Police Action," and finally, "the Forgotten War." But no matter the name, it was still wounding, hurtful, and fatal, killing tens of thousands U.S. soldiers and affecting thousands more lives at home. Tucson residents talk about their memories of the war and of the Tucson area in the late 194...

The Five C's: A Century Later

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 08:00:11 GMT

This is an Arizona Public Media original radio production entitled "The Five C's: A Century Later".      Background: This original radio production looks at the past, present, and future of the state's economic heavyweights - cattle, citrus, climate, copper, and cotton.

Arizona's Dust Bowl: Lessons Lost

JianlingL@tla.arizona.edu — Mon, 03 Jun 2019 07:59:39 GMT

This is an Arizona Public Media original documentary entitled "Arizona's Dust Bowl: Lessons Lost".      Background: This original television documentary explores the effects of the 1930's dust bowl, not only on Arizona's economy, but also on the area's demographics and culture.

2018 Congressional District 3 Debate

JianlingL@tla.arizona.edu — Fri, 31 May 2019 10:15:56 GMT

This is an Arizona Public Media original video production entitled "2018 Congressional District 3 Debate".      Background: This original video production features the live televised debate of 2018 Arizona Congressional District 3 candidates.

Paper Spacecraft Model

JianlingL@tla.arizona.edu — Wed, 29 May 2019 16:29:26 GMT

This is an educational model of the OSIRIS-REx spacecraft for kids to assemble. Background: The OSIRIS-REx Spacecraft’s mission is to explore the Bennu asteroid. This real-life spacecraft carries a payload that includes five science instruments, a Touch-and-Go Sample Acquisition Mechanism (TAGSAM), and a Sample Return Capsule (SRC). The spacecraft is powered by two solar panels. The spacecraft is 20.25 feet long when the solar panels are deployed, its width is 8 feet by 8 feet, and it has a height of 10.33 feet. The science instruments are used to map B...

321-Science Videos

JianlingL@tla.arizona.edu — Wed, 29 May 2019 16:29:10 GMT

Series of educational videos that provide information about the OSIRIS-Rex mission and fun facts about asteroids and comets in the Earth’s solar system Background: The OSIRIS-REx is a spacecraft whose mission is to explore the Bennu asteroid. Asteroid operations began in August 2018 when the first image of Bennu was captured. Scientists believe that Bennu may contain the molecular precursors to the origin of life and the Earth’s oceans. The mission is designed to determine Bennu’s physical and chemical properties. The mission will also determine which natural resou...

Asteroid Alphabet

JianlingL@tla.arizona.edu — Wed, 29 May 2019 16:28:53 GMT

A to Z flashcard deck that includes the name of an asteroid on one side and fun facts about the asteroid on the reverse side. Background: Flashcards are a commonly used educational tool. They are effective and engage the student in essential learning activities. Flashcards: Engage the learner in active recall; a process which actively stimulates the memory during the learning process. Provide an opportunity for the learner to reflect on whether their answer is correct or not. Self-reflection or meta-cognition is another key activity associated with learning. Are an ...

Inexpensive and Processable Polymer Magneto-Optic Nanoparticle Composites for Faraday Rotation: Plastic Garnet Optical Isolators and Sensors

JianlingL@tla.arizona.edu — Wed, 29 May 2019 10:35:33 GMT

This invention includes methods and materials for producing high Verdet constant composite materials. Uses polymers as an inexpensive substrate in which certain types of nanoparticles are embedded. The invention includes detailed processes of how to embed the nanoparticles and prevent the nanoparticles from aggregating in the polymer. The result is an inexpensive material with a high Verdet constant, which can induce rotation of polarized light (faraday rotation) under the presence of a directed magnetic field. The amount of high Verdet material required is significantly reduced, enabli...

Novel 5-Fluorouracil Prodrug For Colorectal Cancer Therapy

JianlingL@tla.arizona.edu — Wed, 29 May 2019 10:17:50 GMT

This invention provides a method for a targeted delivery of a commonly used chemotherapy drug, 5-fluorouracil used to treat colorectal cancer. A pro-drug is released within the colon to release the active ingredient. The method will allow for targeted delivery of 5-fluorouracil to the colon. Background: Colorectal cancer is the third most commonly diagnosed cancer in the world. Patients with colorectal cancer often receive chemotherapy as a primary treatment or as a pre/post-surgery treatment for their cancer. One of the most commonly used chemotherapy drugs used in the treatment of...

Advanced Engineered Formulations of Suramin Microparticles and Nanoparticles for Drug Delivery and Applications Therein

JianlingL@tla.arizona.edu — Tue, 28 May 2019 09:38:13 GMT

Novel Knockout Model Of ER-Beta in Rat Neurons

JianlingL@tla.arizona.edu — Tue, 28 May 2019 09:34:40 GMT

This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta-FloxP-Cre rat that has ER-beta knocked out specifically in neurons. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models of the estrogen receptors that can be genetically regulated across their lifespan. To answer these important questions, a set of five novel rat models have been developed. All five models provide unique opportunit...

Novel Knockout Model Of ER-Alpha in Rat Neurons

JianlingL@tla.arizona.edu — Tue, 28 May 2019 09:33:31 GMT

This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha-FloxP-Cre rat that has ER-alpha knocked out specifically in neurons. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models of the estrogen receptors that can be genetically regulated across their lifespan. To answer these important questions, a set of five novel rat models have been developed. All five models provide unique opportun...

Novel Forebrain Neuron Specific CreERT2 Rat Model

JianlingL@tla.arizona.edu — Tue, 28 May 2019 09:27:10 GMT

This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors. This specific rat model is forebrain neuron-specific CreERT2 rat model under the CamKII promoter. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models of the estrogen receptors that can be genetically regulated across their lifespan. To answer these important questions, a set of five novel rat models have been developed. All five models provide unique opportunities to study the role of ...

Novel Conditional Knockout Model Of ER-Beta in Rats

JianlingL@tla.arizona.edu — Tue, 28 May 2019 09:25:03 GMT

This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta FloxP rat that can be combined with tissue-specific Cre rats to generate ER-beta knockouts in any tissues expressing the estrogen receptor. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models of the estrogen receptors that can be genetically regulated across their lifespan. To answer these important questions, a set of five novel r...

Novel Conditional Knockout Model of ER-Alpha in Rats

JianlingL@tla.arizona.edu — Tue, 28 May 2019 09:23:43 GMT

This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha FloxP rat that can be combined with tissue-specific Cre rats to generate ER-alpha knockouts in any tissues expressing the estrogen receptor. Background: Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models of the estrogen receptors that can be genetically regulated across their lifespan. To answer these important questions, a set of five novel...

Preparacion Translating and Interpreting Curriculum Units

JianlingL@tla.arizona.edu — Fri, 24 May 2019 13:08:02 GMT

This is a collection of turn-key training materials designed to introduce students to translation and interpretation studies in a practical way. The materials include lesson plans, lecture materials, assessments, and exercises. The curriculum presents the concepts of translation and interpretation in a way that recognizes the value of the students’ bilingualism/biculturalism and improves language proficiency in both English and Spanish. The units are intended to be used by both secondary and postsecondary Spanish classrooms. The units focus on the following topics: Introduction to Trans...

Scanning Tunneling Thermometer

JianlingL@tla.arizona.edu — Thu, 23 May 2019 08:50:22 GMT

This invention is a non-contact method for imaging temperature at the sub-nanometer level, with an improved spatial resolution of over two orders of magnitude over existing methods. Background: Thermal imaging of nanoscale circuits could provide critical information on heat flow and dissipation at the quantum level. However, despite significant technological advances using nanoscale thermocouples or SQUIDs as sensors, thermal imaging has yet to achieve nanometer spatial resolution. Achieving good thermal contact with the sample has necessitated operation in the contact regime or the...

Amplified Deformable Mirror (ADM)

JianlingL@tla.arizona.edu — Wed, 22 May 2019 17:28:07 GMT

This invention is an advancement related to deformable mirrors, which incorporates dielectric layers into the mirror’s design. These layers afford a longer stroke than can be achieved by linear actuators. The longer stroke increases the effectiveness of the deformable mirror at longer wavelengths like far infrared. Background: Deformable mirrors enable control of a mirror’s surface to provide wavefront control under conditions such as atmospheric turbulence for astronomy. Deformation of the mirror is typically controlled by linear actuators whose stroke—the t...

A New Method for Preventing and/or Treating Asthma and Related Respiratory Conditions

JianlingL@tla.arizona.edu — Wed, 22 May 2019 10:45:35 GMT

This technology is an intranasal and/or inhaled therapeutic that consists of a bacterial extract. Initial studies have shown that it protects against characteristic asthma phenotypes such as airway hypperresponsiveness, bronchoalveolar lavage eosinophillia, and increased expression of type-2 cytokines in the lung. The therapy can protect against various allergens that are known to cause asthma. Background: Asthma is considered a lifelong disease and can lower quality of life. It is estimated that roughly 25 million people have asthma, with nearly half of these people having an asthma attack ...

Educational Science Kits for use in Traditional, Underserved, Small, or Remote Classrooms

JianlingL@tla.arizona.edu — Tue, 21 May 2019 09:14:29 GMT

This invention is a series of science experiment modules for use as educational tools in underserved, small or remote classrooms. Each experiment illustrates scientific concepts through the use of inexpensive materials that are readily available in grocery or hardware stores. Background: Currently too few students have access to quality educational resources that would allow them to succeed in science, technology, engineering, and math (STEM) - especially in lower-income and remote schools. Since 2010, funding to Title 1 low-income schools has decreased. In addition, traditional lec...

Energy Efficient Switching In Magnetic Tunnel Junctions With An Antiferromagnetic Barrier

JianlingL@tla.arizona.edu — Wed, 15 May 2019 15:58:02 GMT

This invention is a magnetic tunneling junction (MTJ) design to realize more efficient switching. This design includes the use of an antiferromagnetic layer. Background: Spintronics represents a promising solution to address the problem of greatly increased power consumption in CMOS transistors for memory and logic applications. Storing information as spin, instead of charge, spintronics offers a unique route to eliminate energy waste in the stand-by state. A large part of the present spintronics research focuses on reducing the dynamic power consumption and increasing the...

Baro-Balloon

JianlingL@tla.arizona.edu — Wed, 15 May 2019 11:56:45 GMT

This invention is a new medical device designed to replace permanent and invasive methods of weight loss. The device itself is a series of balloons used to gradually decrease the space in the stomach to promote weight loss. Unlike current gastric balloon based interventions that are free-floating and meant to only be utilized in the short term, this technology can be attached to the abdominal wall and can be utilized for long term, sustained weight loss. The technology works to decrease the space in the stomach by increasing the volume in the balloons. This volume adjustment can be done ...

An Essential and Unique Virulence Molecule in Pathogenic Escherichia Coli

JianlingL@tla.arizona.edu — Tue, 30 Apr 2019 11:16:14 GMT

This invention relates to a secreted protein that plays a critical role in mediating virulence of pathogenic E. coli. Utilizing a functionally equivalent mouse pathogen, in both in vitro and in vivo virulence studies, the investigators demonstrated that the premature death of intestinal epithelial cells could be prevented. Background: There are no vaccine or antibiotic options to treat Enterohemorrhagic E. coli associated diarrhea. Pathogenic E. coli is also the leading cause of infantile diarrhea in developing countries. A secreted protein from E. coli prevents the premature d...

Plant-Based Production of Protein Therapeutics, with Constructs, Method and System for Animal Delivery

JianlingL@tla.arizona.edu — Tue, 30 Apr 2019 11:15:41 GMT

This invention provides a method for creating protein therapeutics for treating (primarily) ulceration (throughout the body caused by a variety of diseases) by implementing an Endogenous Grown Human Growth Factor delivery system which is developed by genetic splicing of genes (conducive to produce growth factor proteins) into soybeans while simultaneously using a similar technique to repress plant genes that induce inflammatory, allergenic, or mutagenic responses within humans and animals. Background: Protein therapeutics have emerged as increasingly vital therapy for a wide range o...

Degradation of Aflatoxin B1 in Contaminated Maize

JianlingL@tla.arizona.edu — Tue, 30 Apr 2019 11:08:38 GMT

Inventors at the University of Arizona have developed a method for removing Aflatoxin B1 from contaminated crops by using a specific type of fungus, Pleurotus ostreatus. Aflatoxin concentrations can be reduced from levels considered unacceptable for human or animal consumption to levels at which the products are safe to consume. Furthermore, the method leads to the generation of edible mushrooms free of aflatoxin. Background: Aflatoxins are cancer-causing chemicals that are produced by certain molds that grow in staple foods such as rice, peanuts, wheat, etc. Aflatoxins can also hav...

Divided By Law

JianlingL@tla.arizona.edu — Thu, 11 Apr 2019 15:17:59 GMT

This is an Arizona Public Media program for radio, web, and new media platforms entitled "Divided By Law".      Background: This program looks into the challenges faced by children who are U.S. citizens by birthright but whose parents are undocumented immigrants.

Arizona & Title Vietnam War: Stories of Service, Arizona & The Vietnam War: Jungle Warfare, Arizona & The Vietnam War: Air Combat

JianlingL@tla.arizona.edu — Thu, 11 Apr 2019 14:59:38 GMT

This is an Arizona Public Media 3-part original documentary entitled "Arizona & The Vietnam War".      Background: This original television documentary explores Stories of Service, Jungle Warfare, and Air Combat.

Not Broken

JianlingL@tla.arizona.edu — Thu, 11 Apr 2019 14:54:26 GMT

This is an Arizona Public Media original documentary entitled "Not Broken".      Background: This original television documentary looks into the lives of seven young people living with mental illness, told in their own words.

Swarms of Spacecraft for Flyby Exploration, Mapping and Resource Prospecting

JianlingL@tla.arizona.edu — Wed, 03 Apr 2019 08:41:50 GMT

This invention proposes the use of swarms of small spacecraft to perform space exploration. The swarms are capable of completing the tasks normally given to larger spacecraft and can do so more efficiently. The proposed swarms are applicable for exploring small bodies in space and outer solar system bodies. The results of the proposed invention show that the swarms can fully map and obtain more scientific information through flybys instead of the orbiting conducted by traditional large spacecraft. The invention is capable of performing new missions and reducing costs which typically plague la...

Peer Support Software to Support First Responders

JianlingL@tla.arizona.edu — Fri, 29 Mar 2019 16:41:54 GMT

This invention consists of peer support intervention software used to prevent PTSD in emergency responders. This web application includes a risk assessment of mental health symptoms for those exposed to traumatic events. After the assessment, this software system utilizes a peer support call-out system to connect first responders to peer support members. This invention also provides a means for determining the effectiveness of the program itself so that the using organization can determine if the user is receiving adequate support. It provides a more flexible option for its users and is ...

Virtual Reality Dance Analysis Application

JianlingL@tla.arizona.edu — Fri, 29 Mar 2019 08:12:50 GMT

This invention is an application that analyzes a person wearing a motion capture suit (MoCap) while they are dancing. The application captures the dance performance and then uses pause, rewind and fast-forward functions to analyze their performance. The user is able to analyzing their performance from any point of view desired and maintain complete control while analyzing. Background: It is important, across all levels of dance skill, for dancers to receive valuable feedback and analysis of their performances so that they can expand their skills and continually learn. This inventio...

MSPE Manager

JianlingL@tla.arizona.edu — Fri, 29 Mar 2019 07:53:24 GMT

This technology is a user-friendly and automated software that helps with the collection of required information within the Medical Student Performance Evaluation (MSPE). This software also follows the guidelines set for the by the American Association of Medical Colleges (AAMC). Background: Medical students face a daunting task when applying to residency programs after Medical School. The high number of applicants each year, intense competition, and the limited number of positions available make applying to a residency program a challenging task. The MSPE is a critical factor...

Sustainable Protein Source with Zero Waste

JianlingL@tla.arizona.edu — Thu, 28 Mar 2019 06:12:29 GMT

This invention uses waste streams to produce protein-rich foods. Background: Global population and standards of living continue to increase. This strains available resources, particularly with regard to costs of food production. Animal products require high amounts of land, water, and energy use. However, alternative production methods can provide sustainable and healthy food with less impact. Applications: Sustainably-minded grocers Humanitarian aid Isolated communities Survival kits Pet supply Advantages: Inherently more efficient than meat...

Glycolipid and Mixed Micelle Characterization via Diffusion-Ordered Spectroscopy

JianlingL@tla.arizona.edu — Thu, 28 Mar 2019 05:52:20 GMT

This invention is a spectroscopy method to measure and observe solutions such as aggregates for the purpose of characterizing glycolipid surfactants. Background: Surfactants are known compounds that lower surface tension between two liquids, or a liquid and a solid, with application in detergents, wetting agents, foams, etc. Most industrial surfactants available are ionic and come from sulphate and phosphate salts, however glycolipids are a natural type of surfactant composed of hydrophilic carbohydrates and lipophilic tail. This invention uses diffusion-order spectroscopy (DOSY) to ...

Detection of EMS and EHP

JianlingL@tla.arizona.edu — Thu, 28 Mar 2019 05:44:54 GMT

This technology seeks to improve on conventional Polymerase Chain Reaction (PCR) testing methods for the shrimp aquaculture disease Acute Heptopancreatic Necrosis Disease (AHPND). This new approach is quantitative and targets plasmid toxins that are present in the bacteria that cause AHPND. While conventional AHPND diagnostic PCR kits base their identification on the presence of a single plasmid toxin, this technology improves on this method with increased sensitivity for early diagnosis of this problematic disease. Background: Aquaculture shrimp farming has grown rapidly over t...

Beta-Adrenergic Receptor Activation to Increase the Potency and Safety of Peripheral Blood Stem Cell Grafts

JianlingL@tla.arizona.edu — Thu, 28 Mar 2019 05:39:53 GMT

This technology features a method for altering immune cell composition of peripheral blood stem cell grafts in donors or patients prior to collection and transplantation to treat blood and immune deficiency diseases. The technology aims to alter immune cell subtypes in the graft to evoke increased graft-versus-tumor effects and reduce the incidence of graft-versus-host-disease and latent viral reactivation. Background: Hematopoietic stem cell (HSC) transplantations are effective in treating blood cancers and post-transplant infections. Every year, approximately 60,000 people worldwid...

High Resolution and High Throughput Additive Manufacturing

JianlingL@tla.arizona.edu — Wed, 27 Mar 2019 12:30:22 GMT

Researchers at the University of Arizona have developed an additive manufacturing system that combines several techniques for high-throughput photopolymerization 3D printing. The system is capable of printing large complex components with high resolution features at a high speed, and at a lower cost that current micro-scale 3D printing systems. Background: Over the past few decades, there has been an increasing interest in the fabrication of complex high-resolution 3D parts, using additive manufacturing processes. The known techniques, Stereolithography (SLA), PolyJet Modellin...

Medical Interpreters Training Institute Units

JianlingL@tla.arizona.edu — Mon, 11 Mar 2019 15:44:28 GMT

This invention consists of individual training units that are part of a high-quality, turn-key training curriculum designed for medical interpreters and medical entrepreneurs seeking professional development. Background: The demand for quality medical interpreters exceeds the number of qualified and/or certified interpreters. There are several accredited training programs available for individuals who wish to become medical interpreters and/or acquire certifications, as well as for those seeking continuing education programs. Several of these programs are only provided in face-to-fa...

Integrated Frequency Locked Optical Whispering Evanescent Resonator (FLOWER) based on Raspberry Pi

JianlingL@tla.arizona.edu — Mon, 11 Mar 2019 13:08:15 GMT

Raspberry Pi is a card-sized mini-computer, which acts as a data processing center that replaces the prior commercial frequency locking system. It greatly reduces the size and the weight of the FLOWER system, making it possible for the FLOWER system to be carried by people or mounted on a drone. This optical technology has remote sensing capabilities that can be used in biomedical research for COVID-19. Background: FLOWER (frequency locked optical whispering evanescent resonator) is a patented system, which can measure low concentrations of biological and chemical molecules down to the sin...

Virtual Deflectometry Enclosure Screen

JianlingL@tla.arizona.edu — Mon, 11 Mar 2019 12:49:15 GMT

This invention is a system designed to perform optical quality metrology on freeform or convex optics. This system provides a full aperture surface reconstruction sag map of freeform surfaces. The method relies on the creation of virtual source enclosure that surrounds the unit under testing (UUT) and produces a virtual 2 Pi-steradian measurement range. Background: Freeform optics provide many possibilities in the design of cutting-edge optical systems. However, their fabrication and metrology are challenging. To verify the freeform shape, two non-contact optic...

Phase Unwrapping by Neural Network

JianlingL@tla.arizona.edu — Mon, 11 Mar 2019 12:24:05 GMT

This technology is a novel method for phase unwrapping in optical imaging in a more efficient and accurate way. It uses unwrapping algorithms based on a transport of an intensity equation with a convolutional neural network to unwrap the phase. This novel method uses a multi-class classification process and introduces an efficient segmentation network to identify classes. This allows for a more efficient and effective method in removing the ambiguity that occurs in a wrapped phase. Background: Systems that use modern and mature algorithms to extract phase signals tend to r...

Virtual Patient Assistant (VPA)

JianlingL@tla.arizona.edu — Mon, 11 Mar 2019 12:21:20 GMT

This technology is an Internet of Things (IoT) device aimed at helping patients who are experiencing delirium. The device reminds patients to complete daily tasks, recognizes medical emergencies, and prevents falls in high risk patients through the use of real-time monitoring. It also helps reduce the labor of conducting check-ins, medication monitoring and charting by nurses. Created on a cloud-based system, this technology sends all information directly to the nursing teams in the hospital. Background: As the elderly population increases, the need for better treatments and te...

Microcavity Surface Bioconjugation Using Unilamellar Lipid Membranes For Label Free, Ultrasensitive Detection Of Alzheimer's Biomarkers

JianlingL@tla.arizona.edu — Mon, 11 Mar 2019 11:07:58 GMT

This invention outlines a new way of preparing a microtoroid optical resonator for the purpose of detecting amyloid-β plaque. Traditional ways of surface functionalization leave roughness on the optical resonator, making it difficult to achieve a higher Q-factor. This invention provides a new way of smoothing the surface of a resonator so that ultrasensitive detection can be achieved, providing high Q-factors as well as reduced scattering loss, which is important when detecting key biomarkers such as amyloid-β. This has potential application in biomarker detection for ...

Organic Chemistry Reaction Professional

JianlingL@tla.arizona.edu — Fri, 22 Feb 2019 15:21:45 GMT

This invention is an organic chemistry mobile app designed to improve students’ understanding and mastery of first year undergraduate organic chemistry reactions and their mechanisms. Background: In undergraduate organic chemistry, a student’s success hinges on a deep understanding of chemical reaction types and their mechanisms. For some students, organic chemistry proves to be a difficult subject, and can deter them from pursuing further studies in their chosen area. Since most undergraduates enrolled in organic chemistry are either seeking STEM degrees or are planning on enr...

Cognitive Readiness Test (CRT)

JianlingL@tla.arizona.edu — Fri, 22 Feb 2019 15:19:36 GMT

The multi-domain Cognitive Readiness Test (CRT) is a collection of computerized tasks that can rapidly assess cognitive status. The CRT provides the user with a rapid, portable, computerized assessment for determining acute cognitive status in a field environment. The CRT compares an individual's cognitive functioning at the time of testing to their previously tested baseline levels. Individuals can test at an optimal, marginal, or degraded status relative to their baseline. Background: The importance of the mind cannot be overstated, especially in careers in the military, law en...

Glyonic Liquids for Use as Deep Eutectic Solvents

JianlingL@tla.arizona.edu — Fri, 15 Feb 2019 08:54:54 GMT

A new class of ionic liquids, “glyonic liquids,” have been developed based on carbohydrate-lipid chemistry for use as room-temperature ionic liquids, deep eutectic solvents, and superconducting protonic liquids. A wide variety of chemical structures are available and can be synthetically tuned to tailor resultant properties via either biosynthesized or synthetic production routes. Background: Ionic liquids (IL) have many potential applications, however, commercial uses have been limited due to the cost of these materials, as well as toxicity, corrosiveness, combustib...

Superconducting Glyonic Liquids

JianlingL@tla.arizona.edu — Fri, 15 Feb 2019 08:51:54 GMT

A new class of ionic liquids, “glyonic liquids,” have been developed based on carbohydrate-lipid chemistry for use as room-temperature ionic liquids, deep eutectic solvents, and superconducting protonic liquids and/or immobilized substrates. A wide variety of chemical structures are available and can be synthetically tuned to tailor resultant properties via either biosynthesized or synthetic production routes. Background: Ionic liquids (IL) have many potential applications, however, commercial uses have been limited due to the cost of these materials, as well as toxi...

Carbohydrates with high ionic superconductivity for gas sorbents, electrolytes, solvents

JianlingL@tla.arizona.edu — Fri, 15 Feb 2019 08:46:12 GMT

A new class of ionic liquids, “glyonic liquids,” have been developed based on carbohydrate-lipid chemistry for use as carbon dioxide sorbents, room-temperature ionic liquids, deep eutectic solvents, and superconducting protonic liquids. A wide variety of chemical structures are available and can be synthetically tuned to tailor resultant properties via either biosynthesized or synthetic production routes. Background: Ionic liquids (IL) have many potential applications, however, commercial uses have been limited due to the cost of these materials, as well as toxicity,...

G-Quadruplex Targeting Small Molecules for the Treatment of Castration Resistant Prostate Cancer and HSV-1

JianlingL@tla.arizona.edu — Tue, 12 Feb 2019 12:58:22 GMT

This technology consists of a new class of small-molecules that target G-quadruplex formation. These compounds have the potential to treat a wide variety of diseases including prostate cancer. In particular, these compounds are aimed at helping individuals who have developed a resistance to androgen-deprivation therapies (ADT). While most ADT therapeutics utilize androgen receptor (AR) antagonists or androgen synthesis inhibitors, this technology utilizes specific compounds that work to reduce AR expression, which could potentially help ADT-resistant patients by decreasing overall resistance ...

New Libraries of Disulfide Prochelators and Application of Treating Metal Ion Disregulation

JianlingL@tla.arizona.edu — Thu, 24 Jan 2019 13:18:15 GMT

Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate into iron chelating agents within the reducing environment of the cytoplasm of cancer cells. Background Basic and clinical research has improved significantly the prognosis and number of treatment options for cancer patients in the past...

High Verdet Constant Polymer-Magnetic Nanoparticle Materials for Magneto-Optic Devices

JianlingL@tla.arizona.edu — Tue, 15 Jan 2019 14:29:16 GMT

Polymer-nanoparticle composite materials exhibit much higher Verdet constant performance than the currently-used inorganic metal oxide materials commonly referred to as "garnets," such as terbium gallium garnet (TGG). While TGG has a Verdet constant of around 2000-3000 degrees/Tesla meter, the inventive materials have achieved a Verdet constant of 2500-27,000 degrees/Tesla-meter, representing a 10x enhancement over state of the art TGG material. The inventive materials are also more easily and cheaply processed, than the crystal growth methods required for garnets. ...

Residency Interview Tracker

JianlingL@tla.arizona.edu — Fri, 11 Jan 2019 08:53:37 GMT

The residency interview tracker (RIT) allows fourth year medical students and their advisors to track the residency application season real-time. The goal of creating the RIT was to lessen the financial, time and emotional burden the application and interview process requires . This is achieved on a student by student basis by allowing the advisers to know real-time how the students are faring during interview season and allow the advisors to intervene if necessary. This software will make the interview process for all medical school students and student affair advisers easier, more manageabl...

Tree Caterpillar Traps

JianlingL@tla.arizona.edu — Thu, 10 Jan 2019 07:26:51 GMT

This invention relates to caterpillars as a sustainable food source. Background: Land, water, and energy use required for food production strain available resources, and will continue to do so as the global population and standards of living increase. Protein sources, such as meat, often require significantly more intensive resource use. Traditionally many cultures consume insects as a regular part of their diet. These provide protein, poly- and monounsaturated fats, and essential nutrients, with reduced resource use. This invention facilitates caterpillar harvesting by taking ...

Nematicidal and Antimicrobial Activities of Secondary Metabolites from Photorhabdus Bacteria with Applications in Agriculture

JianlingL@tla.arizona.edu — Thu, 10 Jan 2019 07:20:37 GMT

This invention is novel compounds derived from Photorhabdus bacteria that have antimicrobial and nematicidal properties with an application for agriculture. Background: Agricultural pests result in severe economic losses around the globe. However, intensive use of chemical pesticides has a cost on the environment. There is currently a trend towards developing less harmful pesticides, chemical controls, and management practices. Among biopesticides, one strategy is to use compounds naturally produced in the environment that are both cost-effective and safer than conventional pesticid...

Bed-Sled

JianlingL@tla.arizona.edu — Wed, 09 Jan 2019 14:07:46 GMT

A resistance-training device with the purpose of strengthening the lower extremities, preventing muscle de-conditioning and overall weakness, and formation of blood clots. Background: Surgical patients and members of the elderly population are at an increased risk for developing a blood clot in their lower extremities due to a lack of physical activity. This potentially fatal condition can be prevented with increased attention to the conditioning of leg muscles. The lackluster presence of devices tailored to this condition in the rehabilitation technology market could allow t...

Fuel Cell Metallic Bipolar Plate

JianlingL@tla.arizona.edu — Wed, 09 Jan 2019 14:01:29 GMT

This invention involves three main separate components (others include UA18-212, & UA18-211) that are combined to create a novel, more efficient and less costly high temperature proton-exchange membrane (PEM) fuel cell. The invention is comprised of a polymer membrane, an electrochemical hydrogen compressor, a bi-metal plate and cooling systems. Individually, each component is novel and has advanced capabilities compared to those available on the market. Together, they form an innovative and more efficient fuel cell. While PEM fuel cells exist, and this field is under heavy research and d...

Fuel Cell Electrochemical Hydrogen Compressor

JianlingL@tla.arizona.edu — Wed, 09 Jan 2019 14:00:37 GMT

This invention involves three main separate components that are combined to create a novel, more efficient and less costly high temperature proton-exchange membrane (PEM) fuel cell. The invention is comprised of a polymer membrane, an electrochemical hydrogen compressor, a bi-metal plate, and cooling systems. Individually, each component is novel and has advanced capabilities compared to those available on the market. Together, they form an innovative and more efficient fuel cell. While PEM fuel cells exist, and this field is under heavy research and develop...

Organoboranylsiloxanes and Silsesquioxanes as Thermal and UV Photo Cross-Linking Resin Precursors

JianlingL@tla.arizona.edu — Wed, 09 Jan 2019 13:57:13 GMT

This technology is a new method to facilitate cross linking in UV or photo-cured resins. A specific application of this would be in the manufacturing of acrylic adhesives of many kinds. Acrylate adhesives are commonly made to be light activated, and this technology extends this practice. It enables new chemicals to be used in the formation of UV cured resins. The chemicals have distinct benefits over other precursors used for UV curing of adhesives. Background: Other resin precursors used in acrylic adhesives include ketone amine, peroxides, azo and ben...

Automotive Radar Interference Mitigation Using Adaptive Noise Canceller

JianlingL@tla.arizona.edu — Wed, 09 Jan 2019 13:53:58 GMT

This technology is a new method for mitigating interference in automotive radar systems. It uses an adaptive noise canceler applied on the frequency-domain data of automotive radar. The method has an ideal performance and can be applied to almost all the existing automotive radars. New method using adaptive filtering only needs signal processing and does not rely on costly hardware improvement. It reduces missing targets and false detections in the radar systems and ultimately improves safety for the driver. Background: Currently, almost all of the auto...

Throttling, Descent and Landing of a Projectile Using Spin-Stabilization and Torque-Free Precession

JianlingL@tla.arizona.edu — Wed, 09 Jan 2019 13:51:24 GMT

This invention is a method for landing a projectile using solid rockets for a soft-landing onto the bottom surface of pits on the Moon or other difficult surfaces. The method also includes spin stabilization to ensure the projectile stays oriented for a secure landing. The invention is intended to be used by rovers on the Moon and Mars for discovering the insides of deep pits that are unable to be viewed. Background: Currently, rovers that are sent to the Moon and Mars are unable to explore the depths of pits which may contain forms of past life or water. Whe...

Diagnostic Analyte to Enrich LINE-1 and Detect LINE-1 Driven Oncologic Disease

JianlingL@tla.arizona.edu — Thu, 03 Jan 2019 12:36:58 GMT

This invention is a biomarker model, in which the biomarker detected can be used as a companion diagnostic or for screening and diagnosis of a variety of cancers. The model includes a novel liquid biopsy process that accurately measures biomarkers from blood samples by enriching for cell-derived vesicles shed directly from affected tissues. The data will eventually guide the use of tailored cancer therapies. LINE-1 has been studied as a cancer biomarker for several years; however, it is currently not a reliable biomarker in blood samples. This technique, greatly increases the accuracy an...

Fast Gamma-Ray Interaction-Position Estimation

JianlingL@tla.arizona.edu — Sun, 30 Dec 2018 13:41:31 GMT

Researchers at the University of Arizona have developed systems and methods for estimating gamma ray positions that are faster, more accurate, and more computationally and memory-use efficient than known systems and methods used in the medical imaging field. Background: Scintillator-based detectors have been extensively used in both clinical and pre-clinical SPECT and PET scanners, due to their relatively low cost, high gamma-ray stopping power and fast timing. Position-estimation algorithms or decoding methods are applied for gamma-ray interaction position localization with si...

Design and Synthesis of a New Class of G-Quadruplex-Binding Ligands for the Treatment of Cancer and Other Diseases

JianlingL@tla.arizona.edu — Fri, 21 Dec 2018 07:51:04 GMT

c-Myc is an essential transcription factor that plays an important role in cell proliferation, differentiation, as well as maintenance of other cell-cycle functions. Under pathologic conditions, c-Myc expression is highly elevated, contributing to development of malignancy in majority of human cancers. Thus researchers have been looking for compounds that will attenuate cMyc expression as a novel therapy for cancer. The Hurley lab previously discovered that stabilization of a specific G-quadruplex structure formed in the c-MYC promoter region functions as a transcriptional repressor element. ...

Silicone Aspherical Lens Array for Concentrating Solar Applications

JianlingL@tla.arizona.edu — Tue, 18 Dec 2018 14:38:37 GMT

Researchers at the University of Arizona have designed a silicone based linear lens array capable of high efficiency and low cost. The lens design produces a higher concentration line than traditional lenses, reduces optical aberrations, and facilitates fabrication. The design also creates greater rigidity, reduces Fresnel reflection loss, and eliminates refractive index changes among elements within a complex lens. Background: Current sunlight-concentrating optical elements and/or systems suffer from various deficiencies. For example, mirror-based concentrators require r...

Silicone Waveguide for Solar Applications with High Concentration

JianlingL@tla.arizona.edu — Tue, 18 Dec 2018 14:17:48 GMT

Researchers at the University of Arizona have developed low-cost silicone-based optical light guides configured to concentrate sunlight onto photovoltaic cells with above 90% optical efficiency. The fabrication is inexpensive, affords flexibility, and ease of assembly. Integration of multiple light guides enjoys relaxed alignment tolerances compared to glass. Background: In solar applications, waveguides and/or lightguides are often used to redirect and spatially concentrate the sunlight onto photovoltaic cell (PV-cells). Glass lightguides can be utilized, but can be expensive a...

Novel Inhibitors of the Androgen Receptor for the Treatment of Castration Resistant Prostate Cancer (CRPC)

JianlingL@tla.arizona.edu — Thu, 13 Dec 2018 13:17:12 GMT

This invention is a new class of heterocyclic small-molecules designed to antagonize the androgen receptor. These molecules have promising biological activity in a prostate specific cell line. Background: The primary method for treating early stage prostate cancer is via androgen deprivation therapy because prostate cancer needs androgen in order to fuel growth. However, this form of therapy is sub-par because the tumor can develop a method to circumvent the need for large quantities of androgen by simply adding more androgen receptors. A new method of treatment is needed in or...

Biomarker to Assess Risk For Skin Cancer Development

JianlingL@tla.arizona.edu — Mon, 10 Dec 2018 15:27:33 GMT

This technology is a diagnostic test that can help assess a patient's risk for developing skin cancer by measuring biomarker levels under specified conditions. Additionally, the test can help determine prophylactic treatment for an individual at risk of developing skin cancer. Background: Skin cancer is the most common type of cancer among the Caucasian population worldwide, with an estimated 161,790 cases diagnosed in 2017, 74,680 cases being noninvasive and 87,110 cases being invasive. The estimated total annual cost of treating skin cancers is $8.1 billion in the US. Although ...

Method and Apparatus for Processing Electrochromic Materials and Devices

JianlingL@tla.arizona.edu — Thu, 29 Nov 2018 13:14:02 GMT

This technology is a new process for developing full color electrochromic displays for various industries including a contact printing process for patterning of electrochromic materials on rigid, flexible, and curved areas. In addition, it includes a means for assembly and usage of bench-top automated spray system for low cost, roll-to-roll compatible processing. The invention describes a design and packaging process for liquid electrolytes, flexible materials and protective coating. Lastly, the process includes a portable power supply for electrochromic devices. Background: Electroc...

Integrated Optical I/O Port Combiner

JianlingL@tla.arizona.edu — Thu, 29 Nov 2018 13:12:17 GMT

Researchers at the University of Arizona have designed a polarization splitter rotator (PSR) that enables use of a single optical port for input and output signals simultaneously. This allows the output ports to connect to a wider variety of components and frees up other I/O ports for additional functions, or reduces the number of optical I/O ports required on a photonic integrated circuit. Background: Polarization splitter rotators (PSR) are used to separate the different polarization states of a beam of light entering the input port of the rotator, into different output ports on a photonic...

Fabrication of Polymer Waveguide Interconnect Between Chips with a Gap/Step using Flexible Polymer Dry Film Resist for Photonic Integrated Circuits (PICs)

JianlingL@tla.arizona.edu — Thu, 29 Nov 2018 13:10:57 GMT

This technology describes a new method to form a stable physical barrier between chips within a photonic integrated circuit (PIC), utilizing polymer dry film negative resist. The technique enables the fabrication of polymer waveguide interconnects. Background: The current standard of applying polymer dry film resists works well for a single chip However, when there is a gap or step between two chips, the resist can break at the gap/step upon removing the backing. Applications: Fabrication of polymer waveguide interconnects Potential for use in creating PICs &nbs...

High-Throughput Manufacturing for PIC Polymer Waveguide using Multiple Exposures

JianlingL@tla.arizona.edu — Thu, 29 Nov 2018 13:10:27 GMT

Researchers at the University of Arizona have developed a method of fabricating polymer waveguides in polymer films to form the interconnections between optical devices such as PICs to other PICs and Optical Printed Circuit Boards (OPCBs). Background: An important problem in optical packaging involves the optical interconnection (chip-chip connections) of planar-integrated photonic integrated circuits (PICs) and the connection of such circuits to the external world. PICs allow systems with high complexity and multiple functions to be integrated on a single substrate to allow ...

Measuring Edema and Body Composition in Heart Failure Using NMR-MRI

JianlingL@tla.arizona.edu — Thu, 08 Nov 2018 15:22:17 GMT

This invention is a method of utilizing Nuclear Magnetic Resonance-Magnetic Resonance Imaging (NMR-MRI) technology to assess and diagnose patients with heart dysfunction, heart failure (HF) and those at risk of developing heart dysfunction. It assesses a panel of biomarkers including edema and body composition that will then allow physicians to recommend personalized treatments in order to slow the progression of heart failure. Furthermore, this technology can also be utilized to track the success of treatment for a particular patient over time to determine if the medications being utili...

Biomarker for Heart Failure and Other Related Diseases

JianlingL@tla.arizona.edu — Thu, 08 Nov 2018 14:56:52 GMT

This technology is a method of measuring biomarker activity within a blood sample to treat patients at risk of developing heart disease. This technology looks to stratify patients with heart failure, or potential heart failure, to determine the appropriate medication as well as the appropriate level of medication to use to help treat further progression of heart failure. Background: Each year one in every four deaths in the United States is caused by heart disease, leading to approximately 610,000 deaths. Currently, heart disease is treated with lifestyle changes, medi...

High-Sensitivity Subsurface Sensing System

JianlingL@tla.arizona.edu — Thu, 08 Nov 2018 10:50:11 GMT

The system uses orthogonal antennas and rotation of the beam about its axis to preserve the primary coupling while changing the target coupling. The beam may be either vertical or horizontal. The prototype system currently has a dynamic range of 134 dB, with an expected increase to over 200 dB when a TX moment comparable to that of current commercial systems is used. With the larger TX moment, similar to that of current commercial systems, the ATAC system should be able to detect a standard 2" pipe target at a depth of 9m, i.e....

A Natural Mouse Model that Enables the Discovery and Characterization of Bacterial and Host Factors that Mediate Neisseria Colonization and Persistence, and Targets for Vaccines and Antimicrobials

JianlingL@tla.arizona.edu — Thu, 08 Nov 2018 09:54:52 GMT

This technology is a natural small animal model that circumvents the barriers of host restriction, often seen when studying Neisseria species. This model can be used to study host determinants controlling colonization resistance and factors involved in Neisseria-host interactions and screening therapeutics and vaccines against Neisseria. Background: Neisseria gonorrhoeae (Ngo) and Neisseria meningitidis (Nme) cause several high impact diseases in humans, most notably gonorrhea and meningitis. Ngo causes more than 160 million new infections each year, has developed antibiotic resistan...

A Novel DNA-Based Antimicrobial Compound for Treating Infections Caused by Neisseria Gonorrhoeae and Neisseria Meningitidis

JianlingL@tla.arizona.edu — Thu, 08 Nov 2018 07:56:18 GMT

This invention is an antimicrobial compound made of nucleic acid that can treat diseases caused by the pathogens Neisseria Gonorrhoeae (Ngo) and Neisseria Meningitidis (Nme). Background: Ngo is a common cause of infection globally, and when left untreated, it can cause pelvic inflammatory disease, infertility issues and increased susceptibility to HIV. Many Neisseria strains are antibiotic resistant and are very hard to clear from the system. Current standards require dual therapy in order to try to combat the infection and reduce further development of antibiotic resistance. T...

New Class of Mosquitocides

JianlingL@tla.arizona.edu — Mon, 05 Nov 2018 08:27:09 GMT

Inventors at the University of Arizona have discovered novel methods of synthesis and compounds that have a strong larvicidal effect on Aedes and Anopheles mosquitos. The synthesis can be done in only a few steps and the compounds show a high degree of chemical specificity. Background: Numerous diseases are spread by mosquitoes including Dengue virus, a mosquito-borne virus that infects ~250 million humans per year. Larviciding can be an effective strategy of Integrated Pest Management (IPM) where mosquito larvae are terminated before reaching maturation. Applications: M...

New Class of Natural Product Derived Mosquitocides

JianlingL@tla.arizona.edu — Fri, 02 Nov 2018 16:37:08 GMT

Inventors at the University of Arizona have discovered novel methods of synthesis and compounds derived from natural substances that have a strong larvicidal effect on Aedes and Anopheles larvae. The synthesis can be done in only a few steps and the compounds show a high degree of chemical specificity. Background: Numerous diseases are spread by mosquitoes including Dengue virus, a mosquito-borne virus that infects roughly 250 million humans per year. Larviciding can be an effective strategy of Integrated Pest Management (IPM) where mosquito larvae are terminated before reachin...

Multi-Ring Fused Mosquitocides

JianlingL@tla.arizona.edu — Fri, 02 Nov 2018 16:32:12 GMT

Inventors at the University of Arizona have discovered a novel compound with a strong larvicidal effect on two mosquito species. The compound synthesis can be done in only a few steps and the compounds show a high degree of chemical specificity. Background: Numerous diseases are spread by mosquitoes including Dengue virus, a mosquito-borne virus that infects roughly 250 million humans per year. Larviciding can be an effective strategy of Integrated Pest Management (IPM) where mosquito larvae are terminated before reaching maturation. Applications: Mosquitocides Larvicid...

New Monocyclic Class of Mosquitocides

JianlingL@tla.arizona.edu — Fri, 02 Nov 2018 16:29:19 GMT

Inventors at the University of Arizona have discovered compounds that have a potent larvicidal effect on Anopheles stephensi and a moderate larvicidal effect on Aedes aegypti. The synthesis can be done in only a few steps and the compounds show a high degree of chemical specificity. Background: Numerous diseases are spread by mosquitoes including Dengue virus, a mosquito-borne virus that infects roughly 250 million humans per year. Larviciding can be an effective strategy of Integrated Pest Management (IPM) where mosquito larvae are terminated before reaching maturation. Ap...

Inorganic and Organic Proton=Conducting Polymer Electrolyte Membrane

JianlingL@tla.arizona.edu — Fri, 26 Oct 2018 15:20:54 GMT

This invention contains three main separate components that are combined to create a novel, more efficient and less costly high temperature Polymer Electrolyte Membrane (PEM) fuel cell. The invention is comprised of a polymer membrane, an electrochemical hydrogen compressor, a bi-metal plate and cooling systems. Individually, each compound is novel and has advanced capabilities. Together they form an innovative and more efficient fuel cell. Background: Fuel cells are quickly gaining recognition as the next fuel source for automobiles and public transit systems and are currently ...

High Temperature Fuel Cell System

JianlingL@tla.arizona.edu — Fri, 26 Oct 2018 14:22:56 GMT

This invention contains three main separate components that are combined to create a novel, more efficient and less costly high temperature PEM fuel cell. The invention is comprised of a polymer membrane, an electrochemical hydrogen compressor, a bi-metal plate and cooling systems. Individually, each compound is novel and has advanced capabilities. Together they form an innovative and more efficient fuel cell. Background: Fuel cells are quickly gaining recognition as the next fuel source for automobiles and public transit systems and are currently being researched for uses in a...

Thermally Curable Silsesquioxanes for Direct Write, Laser Inscription of Optics or 3D Printing

JianlingL@tla.arizona.edu — Fri, 26 Oct 2018 14:15:18 GMT

This invention is a thermally curable silsesquioxane based resin used for direct write creation of optics and 3D additive manufacturing. The resin is cured through the inclusion of a ketone and tertiary amine that react with the light from a laser. This leads to crosslinking which aids the gelation and vitrification before the viscous liquid can spread. Background: Direct writing for optics and 3D additive printing offers a more precise and efficient method of manufacturing small scale optoelectronic and dental systems. The present invention is a cost effective and simple soluti...

Additive Manufacturing Using Laser Reactive Sintering of Mixtures of Metallic Powders and Sulfur

JianlingL@tla.arizona.edu — Fri, 26 Oct 2018 14:06:23 GMT

This invention is a new powder mixture of chalcophilic metals or others and sulfur for use in selective laser sintering (SLS), a form of 3D printing. Background: Selective laser sintering (SLS) is a 3D printing technology has typically been used with plastics such as nylon and polystyrene but can also be used with metals such as steel and titanium. By using 3D printing we can use these materials to create ever more complex structures that can't be made through traditional methods. However in selective laser sintering, compounds don't completely melt and fuse together. Instead...

Electrodeposition of Silicon

JianlingL@tla.arizona.edu — Fri, 26 Oct 2018 14:02:52 GMT

This technology is a new method for producing high quality polycrystalline silicon that targets photovoltaic cell manufacturers and other thin film silicon applications. The technology uses a newly discovered reference electrode that allows silicon to be refined from materials that previously could not be tapped. The new method and materials will lower the cost of PV cells and lower the power consumption required by the current production process. Background: Polycrystalline silicon is easier to produce in a lab but has varying levels of purity. Silicon is heated up on a substrate a...

Leukocyte RNA Expression: A Novel Neurosurgical Genomics Technique for Predicting Seizure-Free Outcome following Stereotactic Laser Amygdalohippocampotomy

JianlingL@tla.arizona.edu — Wed, 10 Oct 2018 11:05:06 GMT

This technology provides a novel set of gene-based biomarkers to predict seizure free results in Stereotactic Laser Amygdalohippocampotomy (SLAH) for epileptic patients. These biomarkers are based on leukocyte RNA expression so the prognosis can be easily done by a blood draw instead of a brain biopsy. Background: Drug resistant epilepsy patients are unable to live a standard quality of life as seizures are untreatable with drugs. Candidates for surgery are patients who fail adequate trials of at least two first line medicines and one combination of at least two drugs. SLAH provides...

A Cut and Paste Method for Modification of cMyBP-C in Muscle Sarcomeres

JianlingL@tla.arizona.edu — Wed, 10 Oct 2018 10:50:08 GMT

This technology utilizes unique “spy” proteins, allowing researchers to effectively “cut and paste” desired cMyBP-C sequences that could include a variety of modifications such as point mutations and FRET probes. This method makes the manipulation of cMyBP-C in thick filaments a lot easier. Background: cMyBP-C is an essential regulator of heart muscle contraction. Mutations in the gene that encodes cMyBP-C are a leading cause of abnormal thickening of the heart muscle known as hypertrophic cardiomyopathy (HCM). cMyBP-C has an abundance of dynamic inter...

Percutaneous Vascular Anastomosis: a Device for Creating a Minimally Invasive Vascular Access

JianlingL@tla.arizona.edu — Wed, 10 Oct 2018 10:44:09 GMT

This device consists of an expandable tubular graft that when unsheathed completely creates a branch anastomosis. The device is image guided, minimally invasive, does not require fine suturing, and requires a significantly lower level of procedural training. Background: Hemodialysis replicates kidney functions for those with renal failure, filtering waste out of blood. Blood is taken out, treated, and replaced. Dialysis may occur three times a week with three to four hour long sessions. The traditional methods to get access to the blood involve surgery in the arm or leg through which...

Anti-Reflective Coating for Photonic Materials as Devices using Chalcogenide Hybrid Organic/Inorganic Polymers

JianlingL@tla.arizona.edu — Thu, 04 Oct 2018 11:17:47 GMT

This invention uses chalcogenide hybrid organic/inorganic polymers (CHIPs) with a high refractive index to create an anti-reflective (AR) coating for near infrared and short wave infrared light. These AR polymers may be applied to optical substrates using scalable, inexpensive polymer spin-coating. The very high refractive index of CHIPs enables these materials to be applied as thin film AR coatings for infrared applications. Background: Anti-reflective materials are used as coatings on optical substrates in displays and lenses to increase the amount of light passing ...

Photoresponsive Polymer Films for Photo-Patterned Waveguides

JianlingL@tla.arizona.edu — Wed, 03 Oct 2018 16:48:40 GMT

University of Arizona researchers have developed a new class of high refractive index polymers that can be deposited as thin films and directly photo-patterned into useful device architectures. The resulting cured (e.g. photo-exposed) regions have a reduced refractive index, which is 0.01-0.05 lower than the unexposed regions and, hence, have tremendous potential for new polymer waveguide media using a high refractive index polymer (n>1.75). This new photo-responsive polymer can be easily created using UV exposure and solvent washing. These methods create a refractive index contrast in the...

High Refractive Optical Polymers from Vinylic Sulfide Monomers Amenable to Photoprocessing

JianlingL@tla.arizona.edu — Mon, 17 Sep 2018 14:47:12 GMT

This invention is a new class of hybrid inorganic-organic polymer chemistry for synthesizing high refractive index optical polymers. Monomers for these materials comprise vinylic groups linked to a protecting group capable of being cleaved upon application of an external stimulus. The refractive index of the polymer may be changed during the process of polymerization by the external stimuli. This invention provides an attractive and low cost alternative for polymeric optical devices that require variable and high refractive index materials and allows for facile fabrication o...

Reinforced Chalcogenide Hybrid Inorganic/Organic Polymers (CHIPs) Composites with Isorefractive Fillers

JianlingL@tla.arizona.edu — Mon, 17 Sep 2018 14:40:53 GMT

This invention is a new method to make polymers that possess excellent optical properties with improved mechanical properties. This technology is an improvement to the inventors' existing technology with the goal of producing high sulfur/selenium content polymers. Background: Nearly seven million tons of elemental sulfur are generated as a waste byproduct. Current industrial utilization of elemental sulfur is centered around sulfuric acid, agrochemicals, and vulcanization of rubber. While sulfur feedstocks are plentiful, sulfur is still quite difficult to process. Bec...

Solution Processable Chalcogenide Hybrid Inorganic/Organic Polymers (CHIPs) for Optical Short-Wave Infrared and Mid-Infrared Mirrors and Reflectors

JianlingL@tla.arizona.edu — Mon, 17 Sep 2018 14:38:48 GMT

This invention is a method of producing Chalcogenide hybrid organic/inorganic polymers using an inverse vulcanization process, which results in polymers possessing a high refractive index and are solution processable. Background: Flexible optical mirrors and reflectors in the short-wave infrared and mid-infrared spectrum are critical for the advancement of infrared imaging. High refractive polymers are a possible solution to create such technology but there are currently no synthetic polymers that have sufficiently high refractive index and infrared transparency to do so. ...

Technique for Replication of Volume Holographic Optical Elements

JianlingL@tla.arizona.edu — Thu, 06 Sep 2018 08:55:04 GMT

Researchers at the University of Arizona have developed a method to replicate holographic optical elements (HOEs) in a manner that eliminates the problems with contact copy techniques, and introduces additional functionalities not possible to achieve with those techniques. UArizona's novel process replicates volume HOEs based on optical contact with the master HOE. Unlike common industry variants, no physical contact is required between the master HOE and the copy HOE. Background: Hologram replication is an important topic when considering mass-production of volume holograph...

Chip-to-Chip Switched-Beam Antenna Array With Integrated Feed Network

JianlingL@tla.arizona.edu — Wed, 29 Aug 2018 12:29:45 GMT

This technology allows for a network array of chips to communicate with each other wirelessly. A unique tunable antenna system that is built into each chip allows energy to be guided in order to "talk" to corresponding chips using millimeter waves (mmW). Background: With the emergence of the Internet of Things (IoT), the demand for high performance computing systems is continually growing. Currently, copper interconnects inside of chips have become sophisticated interconnects comprised of switches, chip and wires. When network-on-chip (NoC) is implemented on a large scale,...

Radial Streaking Artifact Reduction Using Phased Array Beamforming

JianlingL@tla.arizona.edu — Wed, 29 Aug 2018 12:27:47 GMT

This invention is a method and software for mitigating the streaking artifact in radial magnetic resonance imaging (MRI). After being tested on MRI scanners and compared to current coil based methods, this new method, known as B-STAR, utilizes phased array beamforming and reduces streak artifacts without any noticeable loss in signal levels. Background: When taking images of large areas of the human body, like the abdomen, obstruction will occur in a streaking artifact. This streaking artifact makes the image difficult to read and significantly lowers the quality, which can result i...

Improved Fused Filament Deposition 3D Printing Using Filaments Coated With Thermoreversible Thermosets

JianlingL@tla.arizona.edu — Wed, 29 Aug 2018 12:24:38 GMT

This invention demonstrates a new polymer to coat the spool of thermoplastic filament used in fused deposition modeling (FDM) 3D printing with a thermoreversible thermoset. The goal is to provide a layer that will liquefy in the hot printer nozzle to produce a lower viscosity liquid polymer. This coats the melted filament and increases the wetting and adhesion between layers, ultimately creating a stronger end product that will hold together well. Background: FDM 3D printing is the most common 3D printing technique. In FDM printing, a spool of thermoplastic filament is used and plac...

Utilization of Elemental Sulfur for Flame Retardant Polymers and Additives

JianlingL@tla.arizona.edu — Fri, 27 Jul 2018 15:22:39 GMT

High Speed Raytracing Method

JianlingL@tla.arizona.edu — Sat, 21 Jul 2018 11:25:41 GMT

University of Arizona researchers have developed methods and associated devices and systems that greatly reduce the computational operations of a ray tracing system by modifying the representations of the optical surfaces and contours in the optical system based on the illumination source. Using the novel method, more than 800 iterations were completed in less than 6 seconds. In comparison, commercial software programs took around 2.22 hours on high precision settings with a single CPU core to complete the same computation. Background: Ray tracing techniques used to d...

New PCR and qPCR Methods For NHP Detection

JianlingL@tla.arizona.edu — Thu, 19 Jul 2018 14:02:44 GMT

This technology provides a more accurate test for detecting necrotizing hepatopancreatitis (NHP) bacteria (NHPB) in farmed shrimp. The development of these highly specific PCR and qPCR methods for detecting NHPB eliminate false positives and non-specific amplifications seen in current detection methods. Background: The worldwide shrimp farming industry has experienced rapid growth in the past 20 years. However, this rapid expansion has been accompanied by devastating viral and bacterial disease outbreaks that have resulted in high mortality rates of shrimp and economic loss to farmer...

Methods for the Detection of Enterocytozoon Hepatopenaei (EHP)

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 17:14:11 GMT

This invention targets Enterocytozoon hepatopenaei (EHP) to help combat the spread of EHP disease in shrimp aquacultures. Background: Enterocytozoon hepatopenaei (EHP) is a fungal disease that affects aquacultures primarily in Southeast Asia but has been recorded in Venezuela as well. EHP severely restricts shrimp growth, causes size variability in the population and increases shrimp susceptibility to acute hepatopancreatic necrosis disease (AHPND) and septic heptopancreatic necrosis (SHPN). Current diagnostics used in EHP identification, such as 18S rDNA sequence-based primers, can ...

Artificial Intelligence To Assist Aquaculture

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 17:04:22 GMT

This technology employs artificial intelligence to identify and predict diseases in aquaculture, particularly in shrimp. This technology also has the potential to be utilized in other types of aquaculture including salmon, trout, tilapia, carp and catfish. Background: There are currently no commercial therapeutics available for any shrimp diseases, especially viral diseases. Preventing the entry of disease-causing agents in culture ponds remains the predominant form of management in shrimp aquaculture. To identify disease, samples from a shrimp population are physically examined and ...

Flow Cytometric Disease Diagnostics Based On Biopsies

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 17:00:17 GMT

This invention encompasses cellular analysis at the nucleus-level in order to diagnose diseases. This level of detail has wide application across eukaryotic species. Background: While single cell analysis is gaining popularity as well as research and development funding, this invention lends itself to more detailed discovery while being technically easier as a method given that the excised cell does not have to remain intact. Applications: Disease diagnosis, prognosis (particularly cancers) Determination of disease predisposition Prenatal diagnosis Drug development ...

Increasing Salt Tolerance in Arabidopsis Thaliana

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 16:55:39 GMT

This technology is a method of conferring increased salt tolerance in Arabidopsis Thaliana, a small flowering plant that is widely used as a model organism in plant biology. Background: With 36% of the world's food supply being produced by irrigated land, a growing challenge exists for food safety and agriculture regarding the treatment methodologies in overcoming salt accumulation in soil. One-fifth of irrigated land world-wide is affected by increased soil salinity, resulting in a global economic cost exceeding $27 billion. Crops grown in high salinity environments experience i...

Monoclonal Antibodies Useful for the Detection of Cryptosporidiosis

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 16:42:49 GMT

Monoclonal antibodies have been developed that detect specific Cryptosporidium antigens. These antibodies are useful for a broad range of research and development purposes and, importantly, these reagents offer the opportunity for the development of a rapid, highly sensitive diagnostic test, capable of simultaneously detecting multiple causative agents of cryptosporidiosis. Background: Cryptosporidium, a protozoan parasite, is a major cause of moderate-to-severe diarrhea in humans worldwide and is also problematic in agriculturally important livestock species. Cryptosporidiosis is a ...

Methods of Using Viral Replicase Polynucleotides and Polypeptides

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 16:39:29 GMT

Methods of Using Viral Replicase Polynucleotides and Polypeptides Applications: Methods for increasing plant cell transformation frequencies, increasing crop yield, providing positive growth advantage, modulating cell division, and providing means of positive selection Advantages: Technology increases transformation efficiency over earlier procedures

Monoclonal Antibodies to the Calpain Small Subunit

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 16:32:43 GMT

University of Arizona researchers have developed antibodies specific to the calpain small subunit. They have developed two hybridoma clones which produce antibodies specific to the 28kDa small subunit of both mu and m-calpain. Background: As calpains have been proposed to be proteases important in apoptotic reactions in human cells, further research into their action is essential to understanding apoptotic reactions in diseases such as cancer and HIV. The antibodies are a useful tool in further understanding the mechanisms of these diseases, and developing treatments for them. Applications:...

Intracellular Reduction/Activation of a Disulfide Switch in Thiosemicarbazone Iron Chelators

JianlingL@tla.arizona.edu — Wed, 18 Jul 2018 15:02:44 GMT

Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, taking advantage of the reducing environment found in the cytoplasm of cancer cells in order to apply redox-directed chelators. Background Basic and clinical research has improved significantly the prognosis and number of treatment options for cancer patients in the past...

Cytomegalovirus Vaccine Backbone that Cannot be Reactivated

JianlingL@tla.arizona.edu — Mon, 16 Jul 2018 15:13:55 GMT

This technology describes a Cytomegalovirus (CMV) vaccine vector with mutations or deletions in newly-found intronic promoters that are important for CMV reactivation. Background: Cytomegalovirus (CMV) is a virus within the herpes family that is extremely common. Nearly 50% of adults will have contracted CMV by the time they reach 40 years old. Once contracting CMV, it lays dormant within the body and can become reactivated later in life. While most people have no symptoms of CMV, it can cause issues in pregnant woman because it can be passed on to the fetus and cause developmental a...

Diagnostic Tool For Estrogen Receptor Positive Breast Cancer Patient Stratification

JianlingL@tla.arizona.edu — Mon, 16 Jul 2018 14:59:14 GMT

This technology is a set of biomarkers to stratify estrogen receptor positive breast cancer patients to see if they should receive anti-estrogen therapy or not. Background: Breast cancer, the second most common cancer among American women, will effect of 330,000 new patients this year. The most commonly diagnosed breast tumors are estrogen receptor positive tumors and these tumors cause the greatest number of deaths among breast cancer patients. Although it has been long been known that estrogen promotes the growth of estrogen receptor positive breast tumors, studies have shown that ...

University Track Pathways Program

JianlingL@tla.arizona.edu — Mon, 16 Jul 2018 09:55:25 GMT

This technology is a comprehensive curriculum program for English as a second language (ESL). The program is designed for students to continue earning academic credit while simultaneously learning English. The curriculum is designed for both undergraduate and graduates students and is supported with trained faculty and staff who specialize in English in an academic setting. The program also serves as a pathway for direct admission to the University of Arizona or another partner without a TOEFL or IELTS score Background: It is estimated that there are over 1.5 billion people learning...

Biomarker Signatures of Platelet Activation

JianlingL@tla.arizona.edu — Wed, 11 Jul 2018 15:15:06 GMT

This invention is a mechanical biomarker signature of shear effects on cells for the purpose of detecting thrombosis early so it can be treated or intercepted prior to a thrombotic event. Background: Thrombosis is a pathophysiological event that can trigger conditions like stroke or heart attack. The efficacy of many antithrombotic agents is shear dependent. Developing a better understanding of the role sheer forces play in thrombosis has many positive medical implications. Mechanical circulatory support (MCS) device performance is impacted by thrombosis and their efficacy can be imp...

“Digital Reflexes”: Quantitation and Signatures of Superficial Reflexes via Stretchable Electronic Wearable Sensors

JianlingL@tla.arizona.edu — Wed, 11 Jul 2018 15:10:31 GMT

This invention provides a method of deep tendon reflex assessment via stretchable electronic sensors containing tri-axial accelerometers and EMG signal detection, which allows for quantitation of motion and EMG "signatures" of a specified reflex. Background: A reflex exam is fundamental in determining neurological issues with upper and lower motor neurons. Traditionally, a standard reflex hammer technique is used to test muscle contraction on a 0-5 scale. This technique is subjectively scored, leading to many inconsistencies. Because of this, there is a need for an innovati...

Drug Metabolite as a Non-Invasive Biomarker for Nonalcoholic Steatohepatitis (NASH)

JianlingL@tla.arizona.edu — Wed, 11 Jul 2018 15:10:18 GMT

This invention is a novel approach to diagnosing patients with Non-Alcoholic Steatohepatitis (NASH). Typically NASH is diagnosed through invasive liver biopsies. This technology evades the traditional risks associated with liver biopsies in favor of a diagnosis that incorporates a pill and collection of corresponding blood or urine analysis to determine the presence of NASH. Background: Non-alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease, affecting 25% of people worldwide and 64 million people in the United States alone. NAFLD costs the U.S. healthcar...

Libra: Comparative Metagenomics With MapReduce

JianlingL@tla.arizona.edu — Wed, 11 Jul 2018 15:08:46 GMT

Libra is an algorithm for all-vs-all genome sequencing tool to identify problematic microbes. It handles large data sets with speed, accuracy and efficiency. Background: Most bioinformatics methods need a reference source of known genomes to ensure accurate measurements of depth and variance. Sequencing and comparing wholly unknown genomes with no reference (all-vs-all) can be unwieldy both in terms of computation and storage, making microbes in complicated samples hard to identify. Libra is constructed on a big data framework, which makes it tailored to scale up for large sequences...

Rotationally Shift Invariant And Multi-Layered Microlens Array

JianlingL@tla.arizona.edu — Wed, 11 Jul 2018 14:06:47 GMT

This invention describes a nontraditional use of the Gabor Superlens and is a configuration of multiple microlens array structures. The rotationally shift invariant and multiple microlens array system provides full-field of view imaging wherein all of the incoming light (i.e., light from all directions), in a solid angle of 4pi steradians, is focused inside the optics. Background: LiDAR and other sensing technologies have need for the collection of light reflected from a scene in full 4Pi steradians with one optical system, but achieving such systems has remained challengin...

Implementing Multiplication And Division In Optics

JianlingL@tla.arizona.edu — Tue, 10 Jul 2018 12:57:41 GMT

This invention is an all-optical approach to implementing mathematical operations on a circuit board in a computer. It uses the non-linear response to light of certain types of thin film materials in a novel approach to multiply & divide numbers in an all-optical mathematical circuit. The approach is an analogue method which implies a constant time for mathematical operation and will not increase as the problem size increases in scale Background: One of the major challenges in electronic computation is the optimization problem occurring in a large data set where each variab...

Chemiluminescence Imaging of Oxidative Stress in Vivo

JianlingL@tla.arizona.edu — Tue, 03 Jul 2018 12:59:14 GMT

This patented invention is a new probe to be utilized for chemiluminescent imaging. This probe allows for in vivo whole animal imaging and has currently been tested in mice. The probe itself is sluggish in a natural biological system but is catalyzed in the presence of horseradish peroxidase (HRP), a commonly used molecule often utilized in the production of antibody conjugates. This probe has been found not to be metabolized within a mouse model and is cleared from the body within eight hours, making it a suitable and safe probe for biological systems. The use of this probe could potentially...

Vulcanization for tire rubber production with lower temperatures, more efficient crosslinking, and improved properties

JianlingL@tla.arizona.edu — Tue, 03 Jul 2018 12:25:25 GMT

Methods of vulcanization using a high sulfur content polymer, instead of elemental sulfur, have been developed for tire rubber production. The resulting high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials have improved polymer compatibility and efficient crosslinking. Furthermore, this technology suppresses "reversion," the loss of rubber stiffness over time, which is an undesirable quality. Background: Vulcanization of rubber and other polymeric materials is a well-established method for enhancing phy...

Disulfide-Masked Prochelators for Intracellular Metal Sequestration

JianlingL@tla.arizona.edu — Tue, 03 Jul 2018 12:13:01 GMT

A novel pro-drug compound is activated into an iron chelating agent within the reducing environment of the cytoplasm of cancer cells. This invention provides enhanced selectivity to target cancer cells as compared to previous iron chelation approaches. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Background Basic and clinical research has improved significantly the prognosis and number of treatment options for cance...

Mosquito Birth Control

JianlingL@tla.arizona.edu — Mon, 02 Jul 2018 16:31:00 GMT

This technology is a new method to control mosquito populations by disrupting mosquito-specific proteins important for embryonic development. Based on a bioinformatics study, a mosquito-specific Eggshell Organizing Factor 1 (EOF1) was discovered, which is not highly conserved in other species. Experiments on mosquitos demonstrated that disrupting the biology of this eggshell formation pathway in the female mosquito after a blood meal results in non-viable eggs. Background: Approximately 80% of the global population is threatened by vector-transmitted diseases such as malar...

Broadband Reflective Coatings for the Near and Short Wave Infrared using Solution Processable Chalcogenide Hybrid Organic/Inorganic Polymers

JianlingL@tla.arizona.edu — Mon, 02 Jul 2018 16:25:54 GMT

High refractive index polymers are used as broad-band infrared reflective coatings in the near and short wave infrared in this invention. These materials are used in multi-layer thin films alternating with low refractive index polymers to create highly reflective IR Bragg reflectors. Coating system design is highly tunable to obtain desired performance using inexpensive, scalable solution processing. Background: Infrared mirrors are used in a variety of applications including imaging, laser mirrors and medical tools. Current limitations to these technologies include ...

Processor Design Tool

JianlingL@tla.arizona.edu — Tue, 26 Jun 2018 11:13:21 GMT

This technology provides a computational approach that effectuates fully automated Network-on-Chip (NOC) design and optimization that is also applicable to processor design. The approach explores the network configuration space to determine, e.g., optimal network latencies, power consumption, and the underlying link/interconnect allocations for any given number of routers, i.e., the ab initio network-on-chip design. Background: Multi-core processors have enabled ongoing computer performance improvement (i.e., trying to keep Moore’s law alive) but at the cost of increasing com...

Smallsat SSA Station

JianlingL@tla.arizona.edu — Thu, 21 Jun 2018 11:50:39 GMT

This technology is a methodology for using multi-static, long baseline interferometry imaging radar with balloon CubeSat satellites for the tracking, imaging, and classification of space objects, particularly objects that are in geosynchronous Earth orbit (GEO). Background: Since the launch of Sputnik in 1957, mankind has progressively added more satellites, and consequently more debris, into Earth's orbit. As of 2013, NASA has tracked over 500,000 pieces of debris larger than the size of an average marble, and this number is constantly increasing. The amount of satellites and d...

Reliable Determination of Contact Angle from the Height, and Volume of Asymmetric Sessile Drops

JianlingL@tla.arizona.edu — Thu, 21 Jun 2018 11:12:44 GMT

This technology is a method for finding the contact angle of a fluid on a surface, which is used to measure characteristics of properties in materials. Background: Current lab methods of determining surface wettability are vulnerable to surface irregularities and system errors, which are difficult to locate and model. This technology overwrites the assumption that more information is always better, using only drop height and volume measurements along with an improved, mathematically elegant calculation. This reduces both uncertainty and systematic errors introduced by the ...

Use of Catalyzed Hydrogen Peroxide (CHP) Chemical System for Stripping of Implanted State-of-the-Art UV Resists

JianlingL@tla.arizona.edu — Wed, 20 Jun 2018 14:54:31 GMT

This invention addresses the use of Catalyzed Hydrogen Peroxide (CHP) chemical systems at low temperatures, less than 80°C, for disrupting crust formed on deep UV resist layers so that the underlying resist layer can be removed easily. Systematic investigation of variables such as hydrogen peroxide and catalyst concentration and time has led to the development of an optimal formulation for attacking the crust. It has been found that effective removal of high dose implanted PR is possible by first exposing the resist to CHP solution at room temperature followed by immersion in 2:1 sul...

Chromium Oxide for Enhanced Magnetic Tunnel Junctions

JianlingL@tla.arizona.edu — Tue, 19 Jun 2018 16:27:35 GMT

This invention is a novel magnetic tunnel junction (MTJ) design, which utilizes an antiferromagnetic material in a new configuration to reduce high switching energies in spintronics. Background: Spintronics represents a promising solution to ever increasing power consumption and heat generation in semiconductor transistors by utilizing both electron spin and charge to store and convey information. Current spintronic technologies may exhibit unacceptably high dynamic power consumption, due to switching energies. Applications: Spintronics Electronics power cons...

Rotationally Shift Invariant Optical System

JianlingL@tla.arizona.edu — Wed, 13 Jun 2018 14:54:56 GMT

Researchers at the University of Arizona have designed a highly sophisticated LiDAR system that uses a novel optical phased array transmitter in conjunction with a novel spherically shift-invariant (SSI) receiver system to provide depth information over a large 2D scene in a single snapshot. The field of view of the receiver is increased by the novel optical design to properly focus incoming light from a large set of angles. The system also improves the depth resolution and reduces position ambiguity. Background: Optical phased arrays have been used for increasing the speed and ...

PVAD: a Linear, Pulsatile, Peristaltic Ventricular Assist Device Mechanism

JianlingL@tla.arizona.edu — Wed, 13 Jun 2018 14:26:15 GMT

This invention is a modified linear peristaltic pump. This pumps utilizes a pulsatile mechanism, other than a traditional rotary pump that is often used in ventricular assist devices, to pump the blood, which help decrease blood clots. Background: Ventricular Assistant Devices (VADs) help consistently pump from the lower chambers of the heart to the rest of the body. A number of pumps offer various benefits, but this linear peristaltic pump presents unique value. A peristaltic pump propels fluid, in this case blood, by a process that most closely mimics biological systems and allows...

Snapshot Interferometer for Surface Profile and Roughness

JianlingL@tla.arizona.edu — Wed, 13 Jun 2018 12:42:46 GMT

Researchers at the University of Arizona have designed an instrument that can take a "snapshot" of a surface's profile and roughness simultaneously. The non-contact metrology tool is high speed with high sensitivity, precision, and resolution. It can be used with a variety of light sources across various applications. Background: Metrology is an integral part of the automated manufacturing process. As new processes become automated, new technology must be developed to handle the imaging of more complex parts quickly, while being low-cost, scalable and, in many...

Attomicroscopy: Attosecond Electron Microscopy and Diffraction

JianlingL@tla.arizona.edu — Wed, 13 Jun 2018 12:27:58 GMT

This technology introduces additional novel components to the conventional optical gating technique and results in electron pulses of less than 20 femtoseconds and even into the attosecond realm. This provides improved temporal resolution for imaging done by electron microscopy and diffraction imaging. Background: Traditional electron microscopes are limited in their temporal resolution. The current state of the art has only achieved 200 femtosecond electron pulse widths. Using faster optical pulses to gate the electron pulses has been limited by the limitations on the optical ...

The Buzz: Alcohol Education Program

JianlingL@tla.arizona.edu — Mon, 11 Jun 2018 13:45:02 GMT

The Buzz is a fun, interactive, game-oriented alcohol education program meant for college and high-school aged students. It is designed to teach students through lively discussion, game play, and competition. This technology is available for licensing by clicking the link. Background: Universities across the country struggle every year to promote alcohol education, awareness, and moderation among their students. Counselors, health educators, and community leaders say that abusive and underage alcohol consumption continues to be the number one health concern at many universities. Trad...

Transgenic Resistance to Cotton Leaf Curl Disease in Cotton

JianlingL@tla.arizona.edu — Thu, 31 May 2018 16:27:29 GMT

This invention utilizes RNA interference techniques to produce a transgenic cotton strain that is resistant to cotton leaf curl disease (CLCuD). These transgenic cotton plants do not produce the characteristic curling of the leaves and do not accumulate the virus. Furthermore, it produces resistance against multiple forms of the virus. This invention has the potential to protect cotton crops from one of the most devastating diseases they encounter. Background: As the most used fiber in the world, cotton is grown in sixty countries that produce over 100 million new bales annually. Th...

Soybean as a Protein Biofactory Platform to Produce Epidermal Growth Hormone

JianlingL@tla.arizona.edu — Thu, 24 May 2018 08:32:52 GMT

This invention is a soybean capable of producing Epidermal Growth Hormone as a therapeutic agent for a number of applications including reduction of necrotizing enterocolitis (NEC). Background: Necrotizing enterocolitis (NEC) is a dangerous condition that occurs in about 10% of premature infants. NEC often requires treatments like surgical removal of diseased and dead tissues. Epidermal growth factor (EGF), which is typically found in bodily fluids like amniotic fluid and breast milk, is known to help reduce the onset of NEC in premature infants. This invention provides a novel ...

Custom Chimeric Antigen Receptor (CAR) T-Cell Therapy for Antigen Attack of Cancer Cells

JianlingL@tla.arizona.edu — Fri, 18 May 2018 15:24:19 GMT

This technology is a new method to develop patient-specific CAR T-cells for conditions characterized by uncontrolled proliferation of T-cells, such as T-cell lymphoma. This approach directs CAR-T cells only to T cells of a given clonal type. There are millions of T cell clones in each patient, each bearing a unique T cell receptor. Here, the inherent specificity of T cells is used to target only malignant T cells clones, resulting in little or no off-target binding and virtually no on-target off-tumor binding. Since typically all the malignant cells in an individual patien...

Producing Environmentally Benign Materials from Mine Tailings using Hydrocarbon Polymerization

JianlingL@tla.arizona.edu — Thu, 17 May 2018 08:56:38 GMT

This invention is a way of making mine tailings more environmentally-friendly and efficient. The method stabilizes the mine tailings by creating a solid product of easily removable heavy metals that, in the event of failure, can devastate the surrounding environment if still present. This technology can be used in the nano-composite fabrication of hydrophobic, non-leaching materials that have a wide range of potential applications. Background: When it comes to mitigating the devastating effects of tailing dam failures, it is not just about preventing a failure in the first plac...

Genetically Engineered Smart Biopolymer to Combat a Broad Range of Microbial Infections

JianlingL@tla.arizona.edu — Thu, 17 May 2018 08:53:18 GMT

This technology is a platform to develop stable protein polymers that have attached antimicrobial peptides (AMPs). This platform involves a novel approach to structurally modify, synthesize and minimize the cost of AMP polymers, specifically for use within clinical settings. Background: Antimicrobial peptides (AMPs) are more efficient at killing antimicrobial-resistant (AMR) microorganisms than antibiotic, antiviral or antifungal drugs. However, AMPs are quickly degraded in the bloodstream and require high dosages, which can have adverse side effects, limiting their uses in a clinic...

Injectable Protein-Based Hydrogels with Ligand-Mediated Reinforcement for Long-Term In Vivo Applications

JianlingL@tla.arizona.edu — Thu, 17 May 2018 08:27:56 GMT

This technology is a protein-based hydrogel that uses cross-links to self-assemble after injection. The technology addresses the issue with in vivo use of hydrogels by merging the biocompatability of a protein hydrogel with a reinforced rupture force typically found in chemical hydrogels. An injectable hydrogel with these properties has immense potential for use in advanced wound care, drug delivery and tissue repair. Background: Hydrogels have compositions of various strengths, breathability, duration and sterility. These compositions are being quickly adopted for advanced wound ca...

Left Ventricular Trans-Apical Dual Lumen Cannula

JianlingL@tla.arizona.edu — Mon, 07 May 2018 16:27:47 GMT

This invention is a dual lumen cannula that can be used to act as a bridge to a decision during an urgent surgical situation. This cannula will be inserted into the left ventricle through an apical ring and can pump in blood and suck out blood at the same time. The entirety of this assembly is designed to be empowered by an extracorporeal pump and connected to necessary tubing. Background: Currently, cardiopulmonary bypass through a median sternotomy in a patient with failing circulation can induce profound coagulopathy and systemic inflammation, necessitating multiple blood transfus...

Triazabutadienes as Cleavable Protein Linkers

JianlingL@tla.arizona.edu — Thu, 26 Apr 2018 10:35:40 GMT

This technology describes water-soluble triazabutadienes as cleavable cross-linkers. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling delivery of the cross-linked molecule. Background: Cross-linking is becoming a valuable practice in chemistry, including for life science applications, with the advent of mass spectrometry. Using cross-linking and "click-chemistry" can enable unique chemical manipulations of linked proteins for various purposes, including drug delivery, diagnostics, and research. Num...

A Memory Assessment for Preschool-Aged Children and Special Populations

JianlingL@tla.arizona.edu — Thu, 26 Apr 2018 10:21:04 GMT

This invention is a neuropsychological assessment test of different memory processes which access the medial, temporal, neural and the prefrontal cortex regions of the brain. It is currently the only comprehensive test for memory and learning designed for children under 5 years old and individuals with cognitive delay. This system uses interactions by the subject with the arrangement of 3-D objects. Assessments include verbal list learning, object recognition, scene recognition, spatial location memory, item in context memory, spatial working memory, verbal working memory, proce...

Multi-Static/VLBI Imaging Radar for Characterizing Space Objects

JianlingL@tla.arizona.edu — Thu, 12 Apr 2018 13:00:47 GMT

This invention is a methodology for using multi-static, long baseline imaging radar for the tracking, imaging and classification of Near-Earth Objects (NEOs). Background: Since the launch of Sputnik in 1957, mankind has progressively added more satellites, and consequently more debris, into Earth's orbit. As of 2013, NASA has tracked over 500,000 pieces of debris larger than the size of an average marble, and this number is constantly increasing. The amount of satellites and debris have posed a problem with the ability to track and image objects, especially those that are small ...

A Pashto-English Dictionary

JianlingL@tla.arizona.edu — Tue, 10 Apr 2018 14:17:45 GMT

This technology is a multi-use dictionary that contains Pashto entries with corresponding English words, allowing individuals to learn either Pashto or English. Background: Current versions of online Pashto dictionaries have varying amounts of Pashto entries with English translations, many of which have no verification of their learning materials, leading to inaccurate entries. The technology presented here is an online learning system that offers individuals over 12,000 entries of Pashto words with English translations. Applications: Learning Pashto or English Machine ...

Novel Diazeniumdiolate-Based Aspirin Prodrugs for Cancer Treatment

JianlingL@tla.arizona.edu — Fri, 06 Apr 2018 16:31:06 GMT

A compound has been developed for releasing controlled fluxes of HNO in physiological media or conditions. The compound undergoes a slow hydrolysis at physiological pH, such that it generates a correspondingly lower steady-state concentration of HNO, minimizing its dimerization/dehydration to N2O. As a result the compound can provide increased efficacy against pain, cancer, or cardiovascular disease. The invention is the formulation of a diazeniumdiolate, a NO donor prodrug. The invention expands on this drug prototype by covalently attaching non-steroidal anti-inflammatory drugs (N...

Optical Gating Of Electron Pulses For Femtosecond And Attosecond Electron Microscopy And Diffraction Imaging Applications

JianlingL@tla.arizona.edu — Thu, 05 Apr 2018 16:22:52 GMT

This technology provides a novel twist on the conventional optical gating technique and results in electron pulses of less that 100 femtoseconds. This provides improved temporal resolution for imaging done by electron microscopy and diffraction imaging. Background: Traditional electron microscopes are limited in their temporal resolution. The current state of the art has only achieved 200 femtosecond electron pulse widths. Using faster optical pulses to gate the electron pulses has been limited by the limitations on the optical pulse widths to drive the gating. Applic...

Narrow-Linewidth Vertical External Cavity Surface Emitting Laser

JianlingL@tla.arizona.edu — Thu, 05 Apr 2018 14:25:55 GMT

This invention uses a strategic placement of the gain chips, cavity mirrors, and polarization elements to address the thermal management issues and eliminate or mitigate mode hopping issues. With the novel architecture, the lasers can be stabilized to provide mode-hop free operation with a narrow line-width of 10 MHz, thus improving the overall efficiency of such systems. Background: A major technical challenge in high-power VECSELs is thermal management. The heat dissipated in small volume/area of the semiconductor device must be removed with minimum temperature rise and ...

Fabrication of Diffractive Patterns on Aspheric Mirror Substrates

JianlingL@tla.arizona.edu — Thu, 05 Apr 2018 08:53:34 GMT

This technology is a novel way of printing diffractive pupils through a means of maskless lithography on any surface. Background: Currently, the fabrication of diffractive pupils is limited to planar surfaces because there are many issues and restrictions with printing diffractive pupils on aspheric mirror surfaces. Printing diffractive structures on a spherical mirror is an inconvenient method currently and causes asymmetric distortion in telescopes. Applications: Printing of diffractive pupils Clearer imaging Precision and accuracy of exoplanets Advantages: Not ...

Field Steering ASLM

JianlingL@tla.arizona.edu — Thu, 05 Apr 2018 08:49:26 GMT

Researchers at the University of Arizona have developed an apparatus and means of using Texas Instruments DLP® Digital Micromirror Devices (DMDs) in more than a binary manner. The novel apparatus and means produces a spatial light modulator that also acts as an angular light modulator. One set of embodiments allows an entire field of an image to be steered for illumination or detection. Background: The Digital Micromirror Device (DMD) is a type of Spatial Light Modulator (SLM) composed of an array of micromirrors. Each mirror, acting as a pixel in a display, is a...

Single-Chip ASLM

JianlingL@tla.arizona.edu — Wed, 04 Apr 2018 16:35:12 GMT

This invention is angular and spatial light modulation using a single digital micromirror device. Background: Projection-type spatial light modulators have been hard-pressed to satisfy requirements for head-up and head-mounted displays. Many current technologies also struggle with similar issues for “no-glasses” 3D displays while maintaining small enough system packages. In similar systems, the etendue of the spatial light modulators (SLM) dictates the field-of-view (FOV) of the observer and the viewing area or eye-box through which the observer can view the di...

Calibration Method for Photon Counting Detectors

JianlingL@tla.arizona.edu — Wed, 04 Apr 2018 15:29:00 GMT

This technology is a calibration method that could be a game changer for adoption of photon counting-based imagery. It solves long-standing challenges in the calibration of detectors used in medical imaging devices and is also useful for security screenings and other imaging photon counting detectors. The method is simple to use, requires less time than conventional calibration methods, and is easy to implement, while also pushing the current state of the art into additional applications. Background: The calibration process for photon counting-based imagery has been a hindrance ...

Amplification of the Incidence Angles of a Light Beam to Cover up to 4pi Steradians

JianlingL@tla.arizona.edu — Wed, 04 Apr 2018 14:42:25 GMT

This invention employs a means of preventing total internal reflection and allows the beam to exit the material to steer at a wider diffraction angle, increasing the incidence angle of a light beam for spatial light modulators and integrated phase arrays. Background: Non-mechanical beam steering requires efficient diffraction and a high angle of incidence. At high angles, the diffracted beam becomes trapped between interfaces and can't exit the material. To allow access to the beam, total internal reflection must be avoided. Applications: Non-mechanial beam steer...

Bidirectional Self-starting Ultrafast Fiber Laser

JianlingL@tla.arizona.edu — Wed, 04 Apr 2018 14:13:03 GMT

This technology is a bidirectional, self-starting, ultrafast fiber that has a mode-locked operation that is assisted by polarization multiplexing optical fibers. It has a specialized non-reciprocal element, which assigns a polarization to a propagation direction and forces the laser to operate in two separate polarizations in at least one part of the cavity. Background: Starting mode-locked operation in a bidirectional fiber laser requires a control system or a technician, and fiber laser systems are typically complex in design. Alignment is difficult and needs to be tweaked often. T...

Polarization Preserving Bidirectional Isolator

JianlingL@tla.arizona.edu — Sat, 31 Mar 2018 15:57:10 GMT

This invention is a bidirectional isolator that can be a stand-alone component, or used to stabilize the output of a bi-directional ultra fast fiber laser. The use of the isolator in such a laser allows the various modes to oscillate with fixed phases with respect to one another and constructively interfere with one another, producing an intense burst or pulse of light. Background: Polarization effects can cause unwanted power and frequency modulation in laser systems generally. In bi-directional lasers, this can cause the lasers to become unstable.&n...

Polygon X-Prism for Imaging and Display Applications

JianlingL@tla.arizona.edu — Sat, 31 Mar 2018 09:21:59 GMT

This invention is a prism with more than three output facets, by including additional optical interfaces inside the cube. For example, all six facets of the cube can be used such that one facet is the input and five facets are the outputs. The invention can apply to even large polygonal prisms, utilizing all facets of the polygonal prism. Background: A conventional x-prism splits an incoming light beam into three beams with equal path lengths and different directions. When operated in reverse, the x-prism acts as a combiner that combines three lights beams f...

Label-Free Single Molecule Spectroscopy and Detection

JianlingL@tla.arizona.edu — Tue, 27 Mar 2018 17:38:54 GMT

This invention incorporates FLOWER with dual frequency comb spectroscopy for molecular detection as well as identification. University of Arizona researchers have improved the signal to noise ratio of these measurements more than 1,000 times using frequency locking feedback control in combination with innovative data processing techniques. This optical technology has remote sensing capabilities that can be used in biomedical research for COVID-19. Background: FLOWER is the acronym for a label-free biological and chemical sensing system known as a Frequency Locked Optical Wh...

Production of HNO from Derivatized Diazeniumdiolates

JianlingL@tla.arizona.edu — Tue, 20 Mar 2018 10:36:53 GMT

A compound has been developed for releasing controlled fluxes of HNO in physiological media or conditions by researchers at the University of Arizona. The compound undergoes a slow hydrolysis at physiological pH, such that it generates a correspondingly lower steady-state concentration of HNO, minimizing its dimerization/dehydration to N2O. As a result the compound can provide increased efficacy against pain, cancer, or cardiovascular disease. Background: Nitroxyl (HNO) is an elusive chemical species that has been shown to possess intriguing biological properties. For exa...

3D Printing Contact Lens

JianlingL@tla.arizona.edu — Sun, 18 Mar 2018 16:49:21 GMT

This invention utilizes a pulsed laser to locally cure optical materials used in fabricating freeform optics, specifically contact lenses. Background: Producing contact lenses is an expensive and time consuming process. However, the need and popularity for contact lenses is rising every year. This technology seeks to alleviate the costs of manufacturing contact lenses by offering a new mode of producing them via 3D printing. Applications: Production of contact lenses Advantages: Strong UV stability Non-yellowing lens High transmission of oxygen Improves temperatu...

A Locking Clamp That Enables High Thermal and Vibrational Stability For Kinematic Optical Mounts

JianlingL@tla.arizona.edu — Sun, 18 Mar 2018 16:46:47 GMT

This technology is a simple apparatus that reduces the angular drift of an optical mount when subjected to thermal or vibrational perturbations. The novel device provides inexpensive mounts with the ability to achieve <2 μrad/C drift when exposed to unbalanced thermal shock either to one part of the mount itself or to the entire optical system. Background: Current commercial kinematic optical mounts suffer from instability when exposed to fluctuations in temperature and vibrations. Often, the only way to mitigate the negative effects of such perturbations is through purchasing ...

Enteral Electrical Constructs

JianlingL@tla.arizona.edu — Tue, 13 Mar 2018 11:23:53 GMT

This invention is a diagnostic and therapeutic system that is composed of ingestible, edible, and nutritive electric/electronic constructs in order to measure various aspects of the entire digestive system. Background: Electronic systems are vital in medical diagnostics and therapeutics, but current electronic systems are based largely on silicon and utilize metallic conductors and synthetic polymer nonporous materials. This invention extends the field of electronics/electrical constructs by fabricating components, devices and systems from completely natural materials. These material...

Natural Treatment for Ventilation Induced Lung Injury

JianlingL@tla.arizona.edu — Tue, 13 Mar 2018 11:03:34 GMT

This invention is the use of bixin, a NRF2 inducer, to reduce lung damage caused by mechanical ventilation. Bixin was found to suppress inflammatory mediators, reduce alveolar capillary leakage, and protect against DNA oxidative damage. Background: Mechanical ventilation is used to assist patients who have difficulty breathing spontaneously in conditions such as lung trauma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, apnea, severe asthma, and patients under general anesthesia. Ventilator induced lung injury may result from mechanical ventil...

Enterocytozoon Hepatopenaei 18S Small Subunit rRNA Gene Nucleotide Sequence and Primers for PCR Detection

JianlingL@tla.arizona.edu — Fri, 09 Mar 2018 13:24:40 GMT

This technology uses a PCR test to detect the enterocytozoon hepatopenaei (EHP) parasite within shrimp. EHP is linked to the growth retardation of shrimp and has been increasingly prevalent in Southeastern Asia since 2009. Background: It is estimated that across the global tropical shrimp industry alone around 40% of production is lost to disease. Specifically to the Southeastern Asia region, EHP is a rapidly emerging problem within the shrimp aquaculture. When a parasite like this emerges bio security becomes number one priority for all parties involved in the food distribution ch...

Veress Needle Interface for Tension Pneumothorax Decompression

JianlingL@tla.arizona.edu — Mon, 26 Feb 2018 14:19:52 GMT

Inventors at the University of Arizona have designed an interface for the modified Veress needle (mVN) to address the shortcomings of older devices used to treat tension pneumothorax such as traditional Needle Thoracostomy (NT). This interface serves as an attachment that adds additional functionality to the standard Veress needle. Equipped with a manual unlock and automatic locking mechanism, this enhancement is durable and includes both a one-way valve to prevent backflow and a flow indicator to monitor whether the device is working properly. In addition, it is compatible with standard Vere...

Advanced Engineered Formulations of Simvastatin and L-Carnitine Microparticle/Nanoparticle Formulations for Inhalation Drug Delivery for Respiratory and Pulmonary Vascular Diseases and Applications Therein

JianlingL@tla.arizona.edu — Fri, 26 Jan 2018 09:37:44 GMT

This invention is novel dry powder formulations of simvastatin and L-Carnitine (separately or combined) for inhalation delivery for pulmonary vascular diseases. Background: Pulmonary vascular diseases are caused by various reasons and may require combined therapies that act through difference mechanisms. Simvastatin inhibits undesired cholesterol production pathways, reducing lipid levels and allowing smoother flow through the veins, which is how it decreases pressure in the respiratory system. On the other hand, L-Carnitine plays an important role in cellular energy metabolism and i...

Portable, Rapid Tests for Shrimp Diseases for use in Novel Testing System

JianlingL@tla.arizona.edu — Thu, 25 Jan 2018 07:38:23 GMT

Background: Diseases that affect the shrimp farming industry can cause a magnitude of problems. Current methods of disease prevention involve taking samples from a pond, which are then typically transported to a lab out of the country for testing. This standard suffers from a lack of portability and is often complex in design. The invention prevented here allows for immediate results, which translates into immediate decisions, thus removing the need to wait long periods for results. Applications: Aquaculture testing Advantages: Portability Rapid response time Simplicity

Motif-Identification in Signal Processing

JianlingL@tla.arizona.edu — Thu, 18 Jan 2018 10:51:41 GMT

This non-invasive electronic device is worn on the body while monitoring vagus nerve activity in order to observe and obtain data about breathing patterns. The software filters and conditions the raw data by using a Fast Fourier Transform (FFT). The software proceeds to apply an error-reducing algorithm which finds the best fit for the conditioned data and transmits the final data set to a separate Bluetooth device for further analysis. This method converts the noisy, raw signal into a smooth, sinusoidal waveform in addition to adjusting for error such that the data accurately represents the ...

Sensor Data Quality Upgrade Framework

JianlingL@tla.arizona.edu — Thu, 18 Jan 2018 10:49:30 GMT

This patent discloses a Sensor Quality Upgrade Framework (SQUF) that employs trained machine-learning models – such as stochastically optimized artificial neural networks – to enhance real‑time, low-quality sensor data (e.g., from wearable devices) into high‑fidelity, medically or otherwise useful output comparable to that from gold‑standard sensors. Background: The invention arises from the growing field of mobile health (M‑Health) – which blends portable, wireless devices (like smartphones, PDAs, and wearable sensors) with healthcare delivery to decentralize care...

Vehicle Protection Mechanisms

JianlingL@tla.arizona.edu — Thu, 18 Jan 2018 10:47:46 GMT

This invention implements mechanisms to manage risks of vehicles overturning including means of outright avoiding obstacles, correcting for tilts, and mitigating consequences from rolls. Engineered guards passively protect from a wide variety of hazards. If the vehicle tilts, angled guards provide stabilization. If the vehicle does roll, certain guard parameters minimize impact and encourage resulting right-side up orientation. Vehicles are made inherently safer in a fundamental way and deployment/mission duration can be extended. Background: Overturning is an inherent risk of vehicl...

A Water-Soluble Prodrug for the Heat Shock-Inducing Compound Withaferin A

JianlingL@tla.arizona.edu — Thu, 11 Jan 2018 07:48:52 GMT

University of Arizona researchers have developed an economically viable and environmentally friendly method for producing and isolating large quantities of both Withaferin A and the novel withanolides. Aeroponic cultivation is a significant achievement as acquiring an abundant supply of starting material is often a significant hurdle in the development of drugs derived from natural products. UArizona researchers discovered that when grown aeroponically, w. somnifera produces a novel class of withanolides that, in vitro, readily convert to Withaferin A and exhibit the anti-proliferative ...

Real-Time Data Warehouse-Powered, Dynamically Generated Simulation System for Complex Processes

JianlingL@tla.arizona.edu — Tue, 09 Jan 2018 15:18:23 GMT

This invention is an automatic simulation generator that can construct highly detailed current or historical models developed for a generic mine. It works by compiling historic and real-time data in a data warehouse to create a highly detailed snapshot of a mine. This software solves a lot of problems with current systems. This software works to create complex algorithms and systems that can be tested with a high degree of accuracy by rapidly constructing simulation models from live or historical data warehouses. Background: Being able to generate simulation models is important ...

Glycopeptide and Classical Drug Design

JianlingL@tla.arizona.edu — Wed, 20 Dec 2017 12:32:15 GMT

This invention relates to the glycosylation drug candidates to increase penetration, bioavailability, and stability. Background: Transmembrane proteins provide a pathway for drugs to interact with a cell's interior. Drugs commonly target G-protein coupled receptors (GPCRs), comprising 40% of the market. Peptides and small molecule drugs directed toward GPCRs inside and outside of the central nervous system (CNS) can treat pain, Parkinson's disease, multiple sclerosis (MS), and other conditions. Carbohydrates improve drug bioavailability and stability to make treatment more e...

Eco-Friendly Dust Control with Biopolymer

JianlingL@tla.arizona.edu — Wed, 06 Dec 2017 15:01:58 GMT

This invention is the use of a biopolymer to stabilize mine tailings for dust control. In addition, the invention describes a flat-ended cylindrical penetrometer to measure the surface strength and dust resistance of mine tailings. Backgrounds: Mine tailings are finely ground rock that remains after valuable metals have been extracted in the milling process. Mine tailings are vulnerable to wind erosion and the dust can contaminate soils, water, and air quality. Current methods to mitigate the dust from mine tailings include adding water, physically cover the mine tailings with g...

Fullerene Assemblies with Tunable Shapes and Electrical and Ionic Conductivity for use as Battery Electrolytes and Other Applications

JianlingL@tla.arizona.edu — Wed, 06 Dec 2017 15:00:39 GMT

This technology is a self-assembling manufacturing process for post manufacture fullerene processing. This method is used to control the shape (rods or flower/fractal) and conductivity. Such materials can be used solid-state electrolytes and components of electrodes and can be doped with alkali metals and has the potential to replace Li diffusion film tech and Li-ion superionic conductors or used in Na/Mg ion batteries. Other potential uses are dictated by the shape and conductivity desired. Background: With an increase in demand and a shift towards the use and ...

Adaptive Multi-Bit Sigma-Delta Modulation Digitizer For Pulsed Waveforms

JianlingL@tla.arizona.edu — Sat, 02 Dec 2017 10:43:22 GMT

Researchers at the University of Arizona have designed, built, and tested a digital-to-analogue circuit (DAC) that utilizes a multi-bit, sigma-delta modulation technique in a novel manner. The DAC captures the transient information as well as the pulse shape and displays it with high resolution even over an extremely short duration. The circuitry minimizes the number of bits required and greatly reduces the circuitry footprint and computational requirements compared to a standard multi-bit sigma delta DAC or a 12-bit conventional DAC. Background: For signals that have rapid tra...

Method to Translate a Non-Collimated Optical Beam

JianlingL@tla.arizona.edu — Sat, 02 Dec 2017 10:16:39 GMT

University of Arizona researchers have constructed a high-speed refreshable Holographic Stereogram (HS) display that avoids the use of a conventional translation stage, allowing for a faster recording speed that supports a fast and continuous update of the HS 3D images. The system produces an image with both spatial and angular structure, preserving the impression of parallax for the viewer. Background: Holographic stereograms (HS's) are a class of integral imaging in which the angular information is stored as holographic pixels (or hogels), diffracting the light in a struct...

Multi-Field Miniaturized Microscope

JianlingL@tla.arizona.edu — Sat, 02 Dec 2017 09:30:43 GMT

This invention is a miniaturized microscope capable of monitoring a number of multiple fields simultaneously and at different depths. All images can be viewed on a single monitor. The microscope has already imaged a mouse brain and can be adapted for neuroscience, cardiac electrophysiology, and imaging of other tissues, all in real-time and at low cost. Background: Existing microscopes that are utilized for imaging provide multi-field imaging, but are constrained in how many regions of interest can be observed simultaneously. Such imaging microscopes are also bulky and expensive, and ca...

Microspectrometer

JianlingL@tla.arizona.edu — Sat, 02 Dec 2017 09:16:26 GMT

Researchers at the University of Arizona have designed a microspectrometer that is very compact and directly interfaces with CMOS sensors; reducing the form factor greatly compared to current micro-spectrometer technology. The microspectrometer is 3D printable, thus reducing the cost of manufacturing to under $100 per unit. Background: There is an abundance of spectrometer technology, for various spectroscopic applications. Although micro-spectrometers have been developed for specialized markets such as the Department of Defense and astronomical applications, those sys...

Advanced Engineered Formulations Of Rho/Rock Kinase Inhibitor (fasudil) Microparticle/Nanoparticle Formulations For Inhalation Drug Delivery For Respiratory And Pulmonary Vascular Diseases And Applications Therein

JianlingL@tla.arizona.edu — Wed, 15 Nov 2017 14:04:30 GMT

This technology is the reformulation of fasudil, a known pharmaceutical, into a dry powder form to facilitate non-invasive, aerosolized administration of the medication. This affords a localized, potent and increased availability of the drugs to the body. The intended purpose of this formulation is to treat pulmonary hypertension and other pulmonary vascular diseases. Background: Pulmonary hypertension is a progressive disease that leads to increased intra-arterial pressure in the pulmonary vasculature leading to heart failure. Fasudil inhibits a pathway in the body that regulates v...

Copper Leaching from its Ores and Concentrates Using Methane Sulfonic Acid (MSA)

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 10:22:51 GMT

The use of methanesulfonic acid (MSA) as an anti-scaling agent in the mining industry has previously been recognized, however the opportunity for MSA to leach precious metals has not been utilized. This invention incorporates the use of MSA during extractive metallurgy, to leach copper and gold simultaneously. The invention’s ability to leach both copper and gold provides unique opportunity in a relatively standard mining industry. Background: In a market dominated by high competition and barriers to entry, the invention’s ability to provide a cost-efficient leachin...

Connected Vehicle Parking Access System (CVPASS)

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 09:30:59 GMT

With the potential to be universal, the Connected Vehicle Parking Access System (CVPASS) is an on-board unit, or vehicle, with the ability to communicate wirelessly to infrastructure for parking, toll roads, etc. System can be used for parking lots and areas that have been previously approved and programmed into the device by the infrastructure’s management. The invention is meant to replace the electronic tag that most, if not all, parking systems and toll areas already use. Background: In the future, connected vehicles will be equipped for wireless vehicle-to-vehicle (v2v) a...

Remediation of 3-Nitro-1,2,4-Triazol-5-One (NTO Explosives) in Water

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 09:25:40 GMT

This technology is a pretreatment step that will aid in the degradation of aromatic compounds with nitro substituents (explosives, TNT, plasticizers, dinitroluene). It involves the injection of an inexpensive reducing agent that results in reduction of one or more of the contaminant’s nitro groups to amines rendering the contaminant more susceptible to conventional oxidation treatment by potassium permanganate (KMnO4). This technology is a method to provide a more practical water treatment system using FE. Background: Presently, in situ chemical oxidation (ISCO) is limite...

Chemical Storage of Methanol or Ethanol in Polymers

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 09:19:00 GMT

This technology allows methanol or ethanol for fuel cells to be chemically stored as part of solid polymers of polymeric gels without evaporation. Additionally, it permits controlled delivery of the alcohols to fuel cells with acid catalyzed hydrolysis. Background: Direct methanol fuel cells (DMFC) are attractive as high-energy power supplies for portable electronics and are increasingly attractive for distributed power production due to the sustainability of bio-based, liquid fuel like methanol. However, the methanol in DMFCs must be diluted with water to less than 3 weight percent ...

3D Filament Printing of Thermoreversible Thermoset Filaments with a Delayed Cure

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 09:17:07 GMT

Filaments made of a thermoreversible thermoset based on Diels Alder cycloadducts are used in 3D filament printing to create 3D artifacts that will irreversibly cure via reaction of reactive diene or dienophile components. This allows filaments to be made and a thermoset to be formed in the final printing. Applications: 3D Printing, prototyping, custom manufacturing, wide variety of industries 3D Printing allows for quick and inexpensive production of custom structures Melt-processable thermoplastics have inferior properties to thermosets 3D Printable thermosets e...

3D Printing Using Peroxide Bearing Powdered Materials as Catalyst/Fillers

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 09:13:32 GMT

This invention involves the inkjet 3D printing of liquid precursors with epoxide or vinyl reactive groups into powder beds of extraterrestrial materials or simulants with catalytic peroxidizing or Lewis acidic metal sites which allows formation of thermoplastic or thermoset composites for agile manufacturing. Applications Allows for conversion of extraterrestrial regolith to valuable manufacturing material Gives astronauts ability to produce wide variety of objects Results in huge savings of fuel and money Could provide better feedstock for 3D printing of ho...

Anorectal Tonometer for Neurological Testing

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 09:09:02 GMT

This invention is an anorectal tonometer intended to measure rectal tone in adults and newborns caused by Cauda Equina Syndrome. CES is not the only thing that can affect the spinal cord; any spinal condition that affects the involuntary nervous system could affect rectal tone. Other conditions this device can be used for include emergency room assessment of spinal cord injuries and intra-operatively during spinal cord surgeries to monitor neural control of the sphincter. Rectal tone often changes during pregnancy and the return of normal function can be studied and monitored to better help w...

Automated Damage Scoring of Zebrafish Neuromast Images

JianlingL@tla.arizona.edu — Wed, 08 Nov 2017 08:30:42 GMT

This invention is an improved method for assessing ototoxicity of pharmaceutical compounds using an automated algorithm. Background: Ototoxicity refers to chemical-related damage to the ear. As a side effect of a drug, the effects of ototoxicity can either be temporary and reversible or irreversible and permanent. Current methods of assessing pharmaceutical compounds for ototoxicity involve exposing a zebrafish to certain dosages while quantifying the damage the fish receives to its neuromast. A large concern with this is how error-prone and inconsistent quantifying the damage ...

Advanced Engineered Formulations of TMP/Ligustrazine and Microparticle/Nanoparticle Formulations for Inhalation Drug Delivery for Lung Vascular, Interstitial and Airway Diseases

JianlingL@tla.arizona.edu — Wed, 01 Nov 2017 15:45:34 GMT

This invention formulates Tetramethylpyrazine (TMP) in a readily deliverable aerosol to treat pulmonary hypertension and other lung diseases. Background: Pulmonary hypertension (PH) is a condition that involves high blood pressure in the arteries of the lungs. Veins stiffen and narrow, making blood flow more difficult and thus, increased pressure is necessary to maintain adequate flow through the vascular system. Pulmonary hypertension leads to a wide variety of effects due to lack of oxygen distribution and extra strain on the heart and veins. Tetramethylpyrazine (TMP or Ligustrazin...

A Biomarker Platform for Parkinson's Disease

JianlingL@tla.arizona.edu — Wed, 01 Nov 2017 15:22:09 GMT

This invention is a biomarker platform for Parkinson's disease (PD). It combines several parameters on a patient's dermal fibroblasts to diagnose and monitor the progression of PD. The parameters can potentially be correlated with specific clinical PD phenotypes and severity. Background: Approximately 60,000 Americans are diagnosed with Parkinson's disease each year, contributing to the 10 million worldwide. Currently, PD is diagnosed at a relatively late stage when the disease has already advanced significantly. Making an accurate diagnosis of PD is difficult a...

Pellet Dispenser for Small Laboratory Animal Cages

JianlingL@tla.arizona.edu — Mon, 23 Oct 2017 12:47:22 GMT

This invention is a timed pellet feeder designed to deliver drug pellets inside a cage. It is comprised of an ejector controlled by a timing module connected to a computer, a pellet hopper, and a feedback unit. Background: Route administration is one of the main challenges in evaluating pharmacological agents for therapeutic efficacy. Traditional methods require administering compounds intra-peritoneally in small animals. Unfortunately, repeated injection can cause stress, callusing at the injection site and increased resources for this manual labor. This invention solves this i...

Powering Implantable Sensors and Devices

JianlingL@tla.arizona.edu — Thu, 19 Oct 2017 15:46:24 GMT

This invention seeks to create a capacitor-based alternative to existing battery-based portable and miniaturized power storage systems that are necessary for powering implanted sensors and devices, down to the micro- and nano-scale level. The proposed technology employs nano-wired ultra capacitors (NUC), composed of a dielectric membrane placed between two thin metal films, which are capable of rapid discharging and charging and have a significant useful lifetime before degradation. Background: Existing batteries, especially those used in implantable sensors, are expensive, inconveni...

Optics Adventures Comic Book

JianlingL@tla.arizona.edu — Tue, 19 Sep 2017 10:25:13 GMT

This invention is an interactive studying tool designed to help students learn science, technology, engineering and mathematics (STEM) subjects. Background: STEM curriculum choices improve schools' competitiveness in science and technology development and are considered important in preparing students to apply their learning to the future work force. However, STEM is also difficult to teach to children. A 2011 study of STEM Smart Brief found that school districts around the nation are averaging less than half the required amount of STEM needed in classrooms. This invention is al...

Calibration Technique for Smartphone Spectroradiometer

JianlingL@tla.arizona.edu — Wed, 13 Sep 2017 14:52:46 GMT

Researchers at the University of Arizona have developed a technique for providing an absolute radiance calibration for a hand-held spectroradiometer that connects to a smart phone. The technique was designed with art museums in mind, but is also extremely useful for cell phone cameras that utilize a hardware driven optical image stabilizer that moves the image on the detector plane for better image stabilizing. Background: Art museums use spectroradiometers to evaluate the degradation of paint on artwork that hangs in a museum for long periods of time. Currently, the ...

Fast and Scalable Fabrication of Microscopic Optical Surfaces and its Application for Optical Interconnect Devices

JianlingL@tla.arizona.edu — Wed, 13 Sep 2017 14:11:26 GMT

Researchers at the University of Arizona have developed and demonstrated a new technique for fabricating 1-micron scale optics and optical interconnects at a fairly high rate of speed and compatible with semi-conductor fabrication (CMOS) processes. The process is relatively inexpensive, utilizing off-the-shelf components arranged in a novel way, addressing the need for competitively priced small scale 1:1 ratio optics and interconnects. Advantages: Can produce 1-um scale optics with a 1:1 shape ratio Fast production Compatible with semi-conductor fab processes Uses off-the...

Fractal Analysis Linking Physical Activity Patterns, Health, and Mortality

JianlingL@tla.arizona.edu — Fri, 08 Sep 2017 09:54:01 GMT

This invention is a novel method for linking patterns from accelerometers to health and mortality problems by measuring fractal complexity. Background: Accelerometers are devices that measure proper acceleration and have multiple applications in different industries. Typically, accelerometers are found in devices that monitor and track physical activity for health-related purposes. The clinical utility of the information tracked by these devices is highly under-utilized. This invention uses de-trended fluctuation analysis (DFA) on raw data taken from wearable accelerometers to allow...

Pharmacogenomics of Intergenic SNPs and in Silico Modeling for Precision Therapy

JianlingL@tla.arizona.edu — Wed, 06 Sep 2017 16:39:15 GMT

This invention is a method for analyzing a single patient’s DNA and modeling how mutations and variations in intra-cell genomics will be expressed in the body. The information may be used to develop highly personalized therapies without the need for huge experimental data sets. Background: Personalized medicine is the next frontier in therapeutics. Unfortunately, highly specific therapies are virtually incompatible with traditional research methods, which focus on generalized efficacy in cohort-level studies. Because of this, inventors at the University of Arizona sought to cre...

Genotyping of Specific SNPs to Stratify Prostate Cancer Risk

JianlingL@tla.arizona.edu — Wed, 06 Sep 2017 15:28:13 GMT

This technology includes several SNP (single nucleotide polymorphism) markers with high potential of clinical utility to identify patients that will develop locally advanced stages of prostate cancer. Background: The worldwide elderly population is experiencing an increase in prostate cancer. For prostate cancer prognosis, PSA levels and biopsy are sometimes inconclusive, leaving doctors and patients a difficult decision on whether to do a prostatectomy or not. These SNP markers (related to microRNA splicing) identified by the inventing team will help them to make a more informa...

Elite REST - A Program for Improving Sleep in Athletics and Occupational Settings

JianlingL@tla.arizona.edu — Wed, 05 Jul 2017 15:43:32 GMT

This invention is a program purposed for improving individuals' sleep by providing a range of tools that can be applied to a variety of situational demands. Background: Sleep plays an important role in living a healthy life because quality sleep can improve your mental and physical health. However, many individuals suffer from insufficient sleep, circadian rhythm disruptions or sleep disorders. Causes can be attributed to work, school or external forces, which can create difficulty in achieving good rest. Current sleep improvement programs are specifically focused on both detect...

Point of Care Microfluidic Aggrogometer

JianlingL@tla.arizona.edu — Thu, 29 Jun 2017 08:57:16 GMT

This invention is a device to assess platelet aggregation for diagnosis of thrombotic diseases and continual monitoring with anti-platelet therapy. Background: Heart disease is the leading cause of death in the United States and, with over 50% of those deaths due to clot formation from myocardial ischemia and infarction. Anti-platelet therapies commonly used are aspirin, clopidogrel, and prasugrel. Monitoring anti-platelet therapy is currently not done on a routine basis due to a lack of a standardized definition of ineffectual anti-platelet therapy. With that said, there is a n...

Integrated System for Comprehensive Flexibility Assessment and Visualization

JianlingL@tla.arizona.edu — Thu, 29 Jun 2017 08:50:34 GMT

This system offers a new way to capture and model flexibility across the entire body using sensors and digital analysis tools. By collecting position and motion data from multiple joints, the system generates a “flexibility envelope,” a 3D (or time-based 4D) visualization of an organism's range of motion across various regions and postures. The flexibility envelope reflects both active flexibility (how far someone can move on their own) and passive flexibility (how far a limb can be moved by an external force, such as a therapist or device). These insights are compiled into a s...

Integrated System for Comprehensive Strength Assessment and Visualization

JianlingL@tla.arizona.edu — Thu, 29 Jun 2017 08:49:59 GMT

This invention introduces a system designed to define and monitor the strength envelope of an organism by integrating real-time motion, position, and force data. Through the use of sensors, such as accelerometers, strain gauges, or pressure sensors, combined with a digital body model, the system generates a full-body representation of strength across various joints and muscles. These data are used to construct a 3D or 4D (time-dependent) “strength envelope” that reflects the capacity and limits of muscular force throughout the body. Importantly, this envelope is not static; it can ...

Polarization and Phase Microscope

JianlingL@tla.arizona.edu — Wed, 28 Jun 2017 12:27:08 GMT

This invention is a novel microscope capable of real-time polarization and phase measurements at a high resolution. Background: Many biological samples involve 3D transparent objects that have similar absorbance and reflection based on their environment, making identification difficult. Conventional microscopy utilizes fluorescence staining and tagging to improve contrast of the sample and environment, however fluorescent agents are not perfect. Some issues involve photobleaching, cytotoxicity and a chance of disturbing cell behavior. Currently, no existing microscope can measure bo...

UAGC Clinical Portal - Software for Clinical Intake and Clinical Orders Management

JianlingL@tla.arizona.edu — Wed, 21 Jun 2017 15:57:41 GMT

Inventors at the University of Arizona have developed a clinical intake and orders management system for use with laboratory information management systems (LIMS). The invention is a portal, for use by clinicians and related staff, to place and manage orders for specific tests. The software is capable of interfacing with various LIMS. In effect, it bridges the gap between clinicians placing orders, tracking the order through wet labs (via the LIMS), and returning results to clinicians. It also allows for profile management of physicians, clinical staff, and even patients’ health insuran...

Ionic Plastic Filled Nanowire Ultra Capacitor

JianlingL@tla.arizona.edu — Tue, 13 Jun 2017 14:24:09 GMT

The unique feature of this invention is the manufacturing process, which uses commercially available or customized dielectric membrane templates with nano-pores to increase the surface area of the conducting materials allowing for more capacitance per unit area than a parallel plate capacitor could ever hope to achieve. This process will most likely impact integrated circuits and portable electronics, but due to its small size and unique features it may find its way into new applications not conceived of today. Digitated capacitors have been fabricated using commercial filters such as p...

Nano-Based Broad-Band Photon Detector Array

JianlingL@tla.arizona.edu — Fri, 09 Jun 2017 14:28:51 GMT

This invention is a thermoelectric photon detector technique that achieves high density of photon detectors. This technique also allows for the construction of a large array or high resolution thermoelectric broad-band (UV-IR) single photon detectors. Background: With many studies and reports published regarding photon detectors, the majority of these sources focus on a single nanostructure or arrays with poor resolution/spacing. Although single nanostructures are often used for photon detectors, this invention allows for the creation of a large array of photon detectors through the ...

Image-Guided Microwave Therapy

JianlingL@tla.arizona.edu — Tue, 06 Jun 2017 09:54:21 GMT

This invention seeks to combine an improved method of treating T1 to T4 breast cancer through a tumor treatment system that both treats and monitors tumor cells with a combination of focused microwave therapy (FMT) and spectroscopic thermoacoustic imaging (STI). The goal is to employ heat to destroy or reduce tumors while minimizing invasiveness and tracking the treatment's effects. Background: Traditionally the treatment of breast cancer is relegated to invasive surgery, chemotherapy, radiation treatments, and hormonal therapy. Because these treatments have potentially harmful s...

A Diagnostic Test for Schizophrenia

JianlingL@tla.arizona.edu — Fri, 02 Jun 2017 13:10:42 GMT

This invention is a method by which schizophrenia can be diagnosed by providing patients with a single dose of antipsychotic medication and a questionnaire. The questionnaire serves to determine their degree of sleepiness/sedation in response to the medicine, which aids in dictating their diagnosis. In addition, a blood test for serotonin 2A receptors, biomarkers associated with schizophrenia, can be administered quickly and without specialized training. Background: Schizophrenia can only be diagnosed by a specialist after spending months, if not years, becoming familiar with a ...

Copolymerizations of Elemental Sulfur with Epoxy Functional Styrenics: An expected route to sulfur polymer networks with improved thermomechanical properties

JianlingL@tla.arizona.edu — Wed, 31 May 2017 15:35:05 GMT

The present invention relates to compositions and methods of synthesizing sulfur copolymers from elemental sulfur and epoxy functional styrenics. In particular, the sulfur copolymers described herein can have improved thermomechanical properties.

Detection of Protein: Nucleic Acid Interactions by Differential Chemical Conjugation

JianlingL@tla.arizona.edu — Wed, 31 May 2017 15:34:48 GMT

This invention features methods, systems, and compositions for detecting interactions between biomolecules. The methods or systems of the present invention may feature comparing the amount of labeling or modification of a molecule in a test sample with the amount of labeling or modification of the molecule in a control sample. For example, the method may comprise subjecting the molecule of interest in the sample to a reaction adapted to modify and/or label one or more areas or residues (e.g., amino acids, nucleotides, etc.) of the molecule of interest. The method may further comprise mak...

Quantitative Detection of Protein Misfolding or Aggregation by Chemical Labeling

JianlingL@tla.arizona.edu — Wed, 31 May 2017 15:34:17 GMT

This invention describes methods and systems for detecting, comparing, or evaluating proteins in a folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for a variety of applications including but not limited to evaluation of protein aggregates levels related to a particular disease (e.g., aggregate-associated disease, etc.), for study of disease progression, drug development for therapeutics at...

Solubilization of Elemental Sulfur for Free Radical Copolymerizations via Organo-ring opening Activation

JianlingL@tla.arizona.edu — Wed, 31 May 2017 15:33:35 GMT

This invention describes a method to solubilize elemental sulfur using a method that allows for a wide variety of comonomers to be added for the formulation of chemically valuable products. Background: Existing methods typically involve sulfur being heated up to temperatures as high as 300 degrees Celsius. The environment in this heat renders certain monomers ineligible for copolymeric use with sulfur. By using nucleophilic activators, reversible linear polysulfide species can be formed. Applications: Batteries and energy storage Existing sulfur copolymerization rea...

Underwater Adhesives

JianlingL@tla.arizona.edu — Wed, 31 May 2017 15:33:08 GMT

This technology provides a method for underwater adhesion through the use of a masked compound that, when exposed to water, forms covalent bonds with surfaces containing phenols. Background: It is extremely difficult to repair cracked or broken surfaces that are exposed to water (i.e. boat hulls, swimming pools, human tissues, etc.) without the high host of draining the water away or physically removing the object from the water. Therefore, a compound which naturally reacts in the presence of water to form a strong bond would offer significant utility for a variety of direct underwat...

Polymer Foams from 1,2,4,5-Tetrazine and Polydienes

JianlingL@tla.arizona.edu — Wed, 31 May 2017 15:13:20 GMT

This invention is an optimized synthesis of parent 1,2,4,5 tetrazine and polydienes, which is capable of creating a solid polymeric foam with as little as 5 mol% tetrazine. Background: Polymer foams are found virtually everywhere in our society and are used in a variety of applications. Said foams can be produced through different methods such like pouring slab-stock, extrusion and molding. The technology presented here is a tetrazine synthesis that is more soluble in polymers than previously reported methods while additionally creating a residual tetrazine free colorless foam. &nb...

Single-Chip Streak Camera and Illumination System

JianlingL@tla.arizona.edu — Tue, 23 May 2017 13:23:32 GMT

This invention uses an Angular Spatial Light Modulator (ASLM) in a projection mode, to create a streak camera. With a novel arrangement of illumination and digital micro-mirror devices (DMDs), an "image per angle" system can be created. Angularly sequential images abut one another such that the viewer sees a single continuous image. Background: Some types of 3D image projection systems place one image on one eye, and an angularly differentiated image of the same scene on the other eye simultaneously. The combined images create a 3D "data cube"...

Angular Spatial Light Modulator (ASLM)

JianlingL@tla.arizona.edu — Tue, 23 May 2017 12:55:48 GMT

This invention is an Angular Spatial Light Modulator (ASLM) using a novel arrangement of illumination and digital micromirror devices (DMDs). The invention can simultaneously modulate spatial and angular content of light with a potential total bandwidth of 1Tera pixel-angle per second (1G in space and 1K in angle). Background: Optical systems control light spatially (the distribution of light on a single plane) and angularly (the propagation of light between planes). The current means of controlling light through the angular domain is limited because it relies on a motorized sc...

Photonic Active Coatings

JianlingL@tla.arizona.edu — Mon, 08 May 2017 15:17:30 GMT

Researchers at the University of Arizona have developed a novel technology that enables dynamic modification of a an optical surface coating for wavefront control. These can be applied for use with high-density deformable mirrors, switchable diffractive pupils, and photonic focal plane masks. Background: High-contrast imagery, such as searching for dark exo-planets orbiting bright stars are stymied by the fixed nature of the coatings. In addition, the current technologies for electrically or mechanically deformable mirrors and other adaptive optics are complex and limited ...

Time of Flight Sensor and Camera

JianlingL@tla.arizona.edu — Mon, 08 May 2017 14:39:10 GMT

Researchers at the University of Arizona have developed a time-of-flight system that can be used for real-time 3D imaging of indoor and outdoor objects. A novel arrangement of components takes advantage of a high frequency modulator to provide high-resolution depth information at high speed. The source can be continuous wave or pulsed. The novel system also provides additional information such as material properties. It would be particularly advantageous in 3D facial recognition for security purposes. Background: Conventional time-of-flight (ToF) detectors...

Broadband Infrared Microscope Objectives

JianlingL@tla.arizona.edu — Mon, 08 May 2017 13:58:46 GMT

This technology is a design for an objective lens that can be used for infrared microscopes to minimize chromatic aberrations, specifically chromatic change of focus and magnification. Although this design broadens the high-resolution, high NA spectral bandwidth in any wavelength region, it also extends the spectral band into the infrared. One design in particular uses as few as six elements, one material, and has a spectral bandwidth from 2 microns to 12 microns. Background: Chromatic change of focus and magnification are among the most difficult aberrations to solve when it comes t...

Digital Micromirror Device Based Beam Steering

JianlingL@tla.arizona.edu — Mon, 08 May 2017 13:52:36 GMT

Researchers at the University of Arizona have designed a beam steering system that works over a large range of wavelengths, with a relatively large field of view, high scan rate, and large beam size, while minimizing the number of moving parts. The invention includes a novel architecture for the illumination and scanning components. Background: Beam steering technology is essential for Light Detection and Ranging (LIDAR) systems. Mechanical scanning systems including gimbals, fast-steering mirrors, Risley prisms, rotating polygon mirrors and gratings have been used fo...

A New Method for Preparing Stabilized Lipid Membranes

JianlingL@tla.arizona.edu — Thu, 04 May 2017 10:08:00 GMT

This invention describes a new straightforward method to prepare stable lipid membranes to maximize its capabilities and usage in the bio/nanotechnology field. The combination of polymer materials via this new polymerization technology that provides stabilized membranes enables new bio/nanotechnology platforms to be realized at its full potential. Background: Phospholipid bilayers play key roles in biology by providing and electrically insulating layer between the intracellular and extracellular environments. Phospholipid bilayers also provide they scaffold to support membrane proteins that ...

Water-soluble Triazabutadienes that Release Diazonium Species upon Physiologically Relevant Protonation

JianlingL@tla.arizona.edu — Thu, 04 May 2017 09:53:24 GMT

This technology is a class of water-soluble triazabutadienes that deposit desired molecular diazonium salt cargo in a pH sensitive and reactive manner. The triazabutadiene is stable at higher pH values, allowing the decomposition to be controlled. Background: Certain viruses and pathogens, such as the dengue virus (DENV), have pH sensitive pathways and chemistries. While molecules exhibiting these characteristic processes have been studied in the past, known methods are reversible and do not exhibit the same level of pH sensitivity and reactivity as the biological counterpart. This research...

Glycoconjugates of Antiproliferative Iron Pro-Chelators Targeting Cancer Cell Metabolism

JianlingL@tla.arizona.edu — Thu, 04 May 2017 09:44:51 GMT

This technology provides novel glycoconjugates of antiproliferative iron pro-chelators that target the altered metabolism of cancer cells. The key to the success of chelation therapy in cancer treatment is the ability to target iron ions in malignant cells without affecting iron levels in the bloodstream and in normal tissues. Lacking such selectivity, currently available chelators have been found to elicit adverse side effects when employed in cancer research. The success of this technology centers on the iron pro-chelators with a glucose-targeting unit, allowing for selective targeting of ...

Paddlewheel ARID Algae Raceway

JianlingL@tla.arizona.edu — Wed, 03 May 2017 09:42:25 GMT

This invention is an Algae Raceway Integrated Design (ARID) that improves upon the conventional paddlewheel raceway. The raceway's center airbag deflates at night, which allows the raceway to drain into a deep canal at night. Background: Open pond systems are the most common method of cultivating algae and typically consist of shallow ponds where the algae are exposed to sunlight. Paddlewheel raceway ponds, which are used to keep the algae circulating, often fall victim to uneven flow, uneven depths, and dead zones. Efficient systems are therefore a necessity for large-scale prod...

Spectral-Tagging Technique for Improving Resolution of Dynamic Echo-Planar Imaging

JianlingL@tla.arizona.edu — Fri, 28 Apr 2017 14:04:22 GMT

This invention is a spectral-tagging method that allows for 3X faster speed of acquisition with improved resolution of the targeted physiology. The invention improves upon echo-planar imaging by band-pass filtering different signals to reconstruct a specific spectral peak, resulting in high quality images without aliasing artifacts from multi-band echo-planar imaging signals. Background: Echo-planar imaging is the most widely used pulse sequence for dynamic magnetic resonance imaging. The drawbacks with this process are that conventional protocols result in artifacts, multi-band ima...

Real-Time Signal Processing and Fitting Method

JianlingL@tla.arizona.edu — Thu, 20 Apr 2017 17:16:30 GMT

The patent describes a real-time stress-management system that uses wearable devices/sensors – such as ECG and respiration monitors – to capture physiological waveforms, which are then processed (by smoothing via frequency-domain filtering, averaging, and pattern matching) on a mobile or cloud platform to detect breathing patterns (e.g., yoga-style inhale–hold–exhale rhythms) and deliver timely feedback or relaxation prompts based on the identified stress state, enabling dynamic biofeedback-guided interventions for clinical and digital wellness applications. B...

Long-Range Hyper-Temporal Acoustic Imaging

JianlingL@tla.arizona.edu — Thu, 13 Apr 2017 14:12:32 GMT

The invention is an apparatus for remotely sensing an object using polarization characteristics of light received from the object to determine acoustic information regarding the object. Background: Current methods of free-space optical communication are limited by the atmospheric degradation of operational distance, resolution from detectors, and intensity fluctuations associated with noise. Applications: Remote sensing Free space optical communication Audio capture Advantages: Can identify the object, determine the state of operation of the object, an...

Dihydrotetrazine Antioxidants and Free Radical Reaction Inhibitors

JianlingL@tla.arizona.edu — Mon, 10 Apr 2017 14:32:00 GMT

This invention is the use of dihydrotetrazines as antioxidants to eliminate free radicals. Dihydrotetrazines were found to be superior to dihydropyridazines or hindered phenols in inhibiting free radical polymerization. Background: Dihydrotetrazines donate up to two hydrogen atoms to terminate radical chain or oxidation reactions. These compounds can be prepared in the synthesis of tetrazines or by hydrogenation or reduction reactions. Applications: Plastics/rubber Food Cosmetics Pharmaceuticals Fuel Advantages: Can serve as an alternative antioxidant agent...

Dihydropyridazine Antioxidants

JianlingL@tla.arizona.edu — Mon, 10 Apr 2017 14:31:18 GMT

This invention is the use of dihydropyridazines as antioxidants to remove free radicals, prevent degradation of peroxides, block ultraviolet light, and limit ionizing radiation. 1,4-dihydropyridazines with any number of substituents at the 3, 6- positions or 4,5- positions can generate a variety of antioxidants. Background: The main reason for the failure of elastomers, thermoplastics, and thermosets are related to polymer degradation from oxidation. Antioxidants can delay this failure and the main focal point of innovation. There is an opportunity and need to increase the time...

Enzymatically Released Aryl Diazonium Ions

JianlingL@tla.arizona.edu — Mon, 10 Apr 2017 14:30:05 GMT

This invention is the discovery of triazebutadienes that rapidly release aryl diazonium ions at neutral pH with a half-life of approximately one minute. Background: In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics are the largest portion of newer medications in development, leaving room for the development of novel pathways and techniques to fuel the creation of new therapies. Applications: Pharmaceutical companies Biotechn...

Improved Cathode Materials for Li-S Batteries via Inverse Vulcanization of Sulfur with Vinylic Comonomers and Tungsten Disulfide (WS2) Fillers

JianlingL@tla.arizona.edu — Mon, 10 Apr 2017 14:26:52 GMT

This invention is a novel cathode composite design based on tungsten sulfide particles dispersed within a conductive sulfur polymer backbone, prepared with vinylic comonomers, such as diisobutadiene (DIB). The polysulfide provides high conductivity and stable, robust chemistry in a tuneable and simple 2-D design. Capacity of ~800 mAh/g has been achieved after many charge/discharge cycles. Background: Lithium-sulfur batteries have been heavily researched, due to theoretical advantages of high capacity and energy density by weight, improved safety compared to lithium-ion...

Toll-like Receptor 2 Ligands and Methods of Making and Using Thereof

JianlingL@tla.arizona.edu — Fri, 07 Apr 2017 09:32:17 GMT

Inventors at the University of Arizona have developed a set of 13 high-affinity toll-like receptor 2 (TLR2) agonists. In certain diseases, particularly pancreatic cancer, these receptors are overexpressed. TLR2 agonists are absorbed by these receptors. When the ligands are labeled with fluorescent proteins, the tumors can be identified. Additionally, these ligands can be combined with therapeutic agents to allow them to be absorbed specifically by cancerous tissue. Background: Pancreatic cancer has a 5-year survival rate lower than 6%. Improved survival rates are associated with surg...

Size-Fractionated Plankton Tow

JianlingL@tla.arizona.edu — Wed, 29 Mar 2017 10:37:42 GMT

Inventors at the University of Arizona have developed a netting system designed to separate particles of varying sizes while conducting plankton tows. This configurable setup allows for different sized particles to be separated as they are collected. It also includes improvements made from standard plankton netting, including stability improvements and adjustable buoyancy. Background: Plankton netting is commonly used by limnologists, oceanographers, and resource management agencies for studying plankton and other aquatic materials of interest. Plankton is often collected as part of...

Systems and Signatures for Cardiopulmonary Resuscitation

JianlingL@tla.arizona.edu — Thu, 23 Mar 2017 15:11:54 GMT

This invention is a system and method to quantify optimal CPR through the use of FDA-approved BioStamp wearable sensors. This system will monitor and provide feedback to the CPR provider if CPR is being performed correctly, allowing the CPR provider to make corrections and standardizing the way to individuals are trained in CPR. Background: Results of a study of 67 cardiac arrest patients receiving CPR at the University of Chicago hospitals concluded that 28% of intervals were too slow, 40% of compressions were too shallow, and 60% of the patients hyperventilated. CPR doubles a ...

Rapid, Accurate Diagnosis of a Wound Infection with a Smartphone

JianlingL@tla.arizona.edu — Wed, 08 Mar 2017 08:46:13 GMT

The technology utilizes a smartphone as a point of care diagnostic to identify species of bacteria in a wound via light scattering. Background: The cost for chronic wound care, which is estimated to be $25 billion annually, is mainly due to improper selection of antibiotic treatment and the need to treat an infection quickly. The current method of diagnosing infections is a tissue biopsy and swab culture, a process that can take hours to complete and requires additional resources. In general, if a bacterial species is unknown, broad-spectrum antibiotics are used, which increases the ...

Traverse and Trajectory Optimization and Multi-Purpose Tracking

JianlingL@tla.arizona.edu — Thu, 23 Feb 2017 15:19:44 GMT

This invention is a multivariate optimization framework using stochastic optimization algorithms for planning applications. These algorithms perform model inversions and work with 3D data. This framework provides planning solutions for a variety of applications including surgical procedures, logistics, and transportation. Background: When computational models and simulations are run, various inputs are given to the system. The system then returns the model’s predicted outcome. While these models can be refined to give very accurate predictions, it can be a challenge to run these model...

Novel Biomarker for Diagnosis and Treatment of Chronic Lung Diseases

JianlingL@tla.arizona.edu — Mon, 20 Feb 2017 08:35:14 GMT

This invention is a targeted method of treating conditions associated with aberrant L1 expression, including cancers. The method involves determining the expression levels of L1 in a patient and then administering a known TGF-β1 inhibitor. Further, the invention acts on the discovery of an underlying mechanism of aberrant L1 expression that will allow for drug discovery, biomarker validation, and assay validation for L1 related diseases. Background: Transforming growth factor beta 1 (TGFb1) is necessary to mediate the oncogenic phenotype induced by B(a)P activation o...

Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators

JianlingL@tla.arizona.edu — Fri, 17 Feb 2017 10:01:56 GMT

This invention is a novel strategy to create iron chelators by utilizing a disulfide redox switch to connect carbohydrate moieties to a thiosemicarbazone iron-binding unit. This increases expression of glucose transporters in colorectal cancer cells and greater toxicity to cancer cells. Background: An increased amount of iron in colorectal cancer cells is a general characteristic of malignancy, and higher expression of glucose transporter is related to poorer prognosis. Iron chelators are currently marred with poor selectivity and resulting systematic toxicity as well as side ef...

Application of Neuroprotective Beta Amyloid Core Peptides and Peptidomimetic Derivatives to the Treatment of Alzheimer's Disease

JianlingL@tla.arizona.edu — Fri, 17 Feb 2017 09:57:44 GMT

Despite a notable role for amyloid and amyloid plaques in Alzheimer's disease, treatments aimed at lowering the levels of beta amyloid or disrupting amyloid plaques have had little or no impact on the disease. Using a novel approach, a core hexapeptide fragment derived from beta amyloid has been shown to be protective at the synaptic, cellular and behavioral levels against beta amyloid toxicity and is being used in this invention as a platform for deriving stabilized versions and peptidomimetics for prevention and treatment of Alzheimer's disease. The hexapeptide core beta amyloi...

An Attachment for Benchtop Nuclear Magnetic Resonance Instruments to Prevent Sample Tube Breakage

JianlingL@tla.arizona.edu — Fri, 17 Feb 2017 09:56:57 GMT

This invention is attached to the top of a benchtop Nuclear Magnetic Resonance (NMR) spectrometer and guides a sample tube so that it is effectively impossible to break the tube while it is inside the instrument. It attaches easily to benchtop NMRs and fits the standard size 5mm glass tube. The innovation has the capability to solve the major problem facing benchtop NMRs- equipment breaking in part because of inexperienced users. Background: Nuclear Magnetic Resonance (NMR) is an important method used for compound identification and analysis, and benchtop NMR spectrometers ...

Detection of Folding State of a Macromolecules by Chemical Conjugation

JianlingL@tla.arizona.edu — Fri, 17 Feb 2017 09:50:12 GMT

Methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of the present invention may be used for a variety of applications including but not limited to evaluation of protein aggregates levels related to a particular disease (e.g., aggregate-associated disease, etc.), possibly for diagnostic purposes.

Measuring Blood Brain Barrier Permeation of Peptides

JianlingL@tla.arizona.edu — Fri, 17 Feb 2017 09:39:15 GMT

This method enables quantifying the blood brain barrier (BBB) penetration of endogenous opioid peptides, such as enkaphalins, endorphins, dynorphins, nociceptin, and endomorphins. A measurement system uses a fluidic system and the use of preservative agents to prevent enzymatic degradation of peptides to be measured. Background: Neurological compounds typically need to access the brain to achieve their effect. Due to the blood brain barrier, only specific classes of compounds can successfully achieve this, limiting neurological drug construction. Compounds that can cross the BBB, s...

The Method of Formation of a Class of Oxidation Resistant Linear Polymers and Networked Foams through the Inverse Electron Demand (IEDA) Reaction Between Substituted Tetrazines with Polyenes and Oligoenes

JianlingL@tla.arizona.edu — Fri, 17 Feb 2017 09:30:20 GMT

This invention is a chemical synthesis method that allows for a greener, safer formation of polymeric thermosetting and thermoplastic foams, adhesives, films and electrofluorochromic devices using non-isocyanate chemistry. Background: As of January 2015, the US Environmental Protection Agency (EPA) has taken action to protect consumers from new uses and imports of harmful isocyanates in polyurethane. Traditional methods of manufacturing polyurethane include the use of inherently toxic isocyanate molecules which ultimately produces excess carbon dioxide. Substituting the use of is...

Iterative Dynamic Copolymerization with Elemental Sulfur and Sulfur Oligomers

JianlingL@tla.arizona.edu — Wed, 15 Feb 2017 11:42:43 GMT

This technology is the copolymerization of elemental sulfur with vinylic and other unsaturated comonomers for the preparation of sulfur oligomers that can react with other commercially available comonomers to prepare a wider class of functional sulfur polymers. Background: Nearly seven million tons of elemental sulfur is generated as a waste byproduct. Current industrial utilization of elemental sulfur is centered about sulfuric acid, agrochemicals, and vulcanization of rubber. While sulfur feedstocks are plentiful, sulfur is still quite difficult to process. Because of this, there ...

National Center for Interpretation Deaf Interpreter Certification Examination

JianlingL@tla.arizona.edu — Mon, 13 Feb 2017 13:13:14 GMT

This is a two-part certification examination for deaf interpreters, which ensures they have the critical knowledge, skills, and abilities to competently perform their duties. The qualifications, according to the National Consortium of Interpreter Education Centers, for a deaf interpreter should include: Cultural mediation skills Knowledge of team interpreting protocols Advanced interpreting proficiency - including mirroring, expansion, and VGC skills The ability to incorporate props and environment into the interpreting process American Sign Language (ASL) and English and semi- or non-l...

Todo Ha Cambiado -- Everything Has Changed

JianlingL@tla.arizona.edu — Mon, 13 Feb 2017 13:12:36 GMT

This invention is a 12-minute "telenovela" about an aging, Mexican American adult deciding to use home health care services. The style of the video dramatizes human and family stories, with DVDs available in both Spanish and English. Background: Hispanics are 17% more likely to need assistance once they reach an elderly age compared to others. A study was conducted with this "telenovela" which showed that almost 100% of caregivers who watched the "telenovela" sought home health care services more than those who were not shown the video. Applica...

Obstetrics Critical Care VR Training Volume 1, Episodes 1 & 2

JianlingL@tla.arizona.edu — Mon, 13 Feb 2017 13:12:00 GMT

This invention is a series of educational videos created to be viewed with virtual reality (VR) technologies to provide an experiential learning experience specific to crisis management for obstetric care providers. Background: VR technology is poised to be a disruptive technology that will change the education of health care. VR technology can empower faculty to teach with a focus on increasing resources on monitoring learning physicians in critical thinking, pattern recognition, situational awareness, and comprehensive care instead of didactic knowledge. Applications: ...

Magnetic Tunnel Junctions with Voltage Tunable Interlayer Coupling for Memory and Sensor Applications

JianlingL@tla.arizona.edu — Fri, 10 Feb 2017 08:54:53 GMT

This invention is a new voltage controlled interlayer coupling system and device that utilizes a new perpendicular magnetic tunnel junction approach, where a large perpendicular magnetic anisotropy and a sizable tunneling magnetoresistance have been achieved at room temperature. This provides a new path toward achieving energy efficient magnetization switching by controlling interlayer coupling. Background: Magnetic interlayer coupling, the parallel or antiparallel alignment of ferromagnetic layers in proximity to each other in the absence of external magnetic fields, is one o...

Differential Target Antenna Coupling (DTAC) Data Corrections

JianlingL@tla.arizona.edu — Thu, 09 Feb 2017 13:17:06 GMT

This technology notably enhances the Differential Target Antenna Coupling (DTAC) technology (UA10-041) by orders of magnitude in the measured DTAC response accuracy, allowing for better depth of investigation, improved target location, and improved target characteristics. Background: Current ground-penetrating (GPR) technologies are sensitive to the orientation of the measurement system and to variation in the background resistivity. The DTAC Data Corrections remedies these issues while also reducing the sensitivity to surface clutter. Applications: Near-surface target a...

Holographic Collector to Extend Energy Capture of East-West Mounted Bi-Facial PV Modules

JianlingL@tla.arizona.edu — Sat, 04 Feb 2017 14:46:28 GMT

Researchers at the University of Arizona have designed a holographic optical element that collects direct sunlight during midday time periods and diffracts the sunlight to the surfaces of a vertically mounted bi-facial PV panel. It can easily be integrated with existing bi-facial systems to greatly enhance performance during the midday time periods. Background: Bi-facial photovoltaic (PV) solar cells are designed to capture and convert sunlight on the front and back surfaces of the cell. Vertically mounted bi-facial PV solar cells may be implemented to maximize solar ener...

Relaxed Tolerance Adiabatic Coupler for Optical Interconnects

JianlingL@tla.arizona.edu — Sat, 04 Feb 2017 14:33:33 GMT

Researchers at the University of Arizona have designed an architecture for photonic integrated circuits (PICs) using a waveguide design that reduces the size of the interconnections and overcomes the mode size mismatch. The design also relaxes alignment tolerances and lower polarization dependence to allow for very fast manufacturing of the PIC interconnections. Background: An important problem in optical packaging involves the optical interconnection of photonic integrated circuits (PICs) for chip-chip connections and the connection of such circuits to the external world....

Novel Electrically Pumped VECSEL

JianlingL@tla.arizona.edu — Sat, 04 Feb 2017 13:06:29 GMT

This invention is a high-power, tunable, electrically pumped VECSEL. By use of a novel pumping geometry, the electrically pumped VECSEL is able to attain high output powers with greater efficiency. Background: A vertical-external-cavity surface-emitting-laser (VECSEL) is a small semiconductor laser not dissimilar to the vertical-cavity surface-emitting laser (VCSEL), which is a type of semiconductor laser diode with laser beam emission perpendicular from the top surface. VECSELs are primarily used in near infrared devices for spectroscopy, laser cooling, and telecommunications....

3D Printing Freeform Optics

JianlingL@tla.arizona.edu — Sat, 04 Feb 2017 12:32:51 GMT

Researchers at the University of Arizona have developed a novel apparatus and method for additive 3D printing of visible wavelength optics. The materials used have a low refractive index, and the laser parameters are tailored to deliver high figure and surface quality, making the printer suitable for freeform optics and rapid prototyping of complex surfaces. Background: 3D printing has revolutionized the way that items are built. When it comes to printing optics, the quality of lenses that conventional 3D printers can produce remains low. The objects are often rough and turn yel...

Broadband Polarization and Color Sensitive Focal Plane Array with Thick Optical Filter and Micro-optics Array

JianlingL@tla.arizona.edu — Sat, 04 Feb 2017 12:21:37 GMT

Researchers at the University of Arizona have designed a sensor array with thick IR filters and micro-optics for use in a polarization and color camera. The camera is wide-angle and broad band, yet its design greatly reduces cross-talk between pixels and maintains high resolution. Background: Polarization imaging is key in fields like medicine, remote sensing, and materials science. An ideal system has an optical filter for high transmission, contrast, wide angle, and broadband image. But for infrared wavelengths, the filter can become very thick, making it difficult to have wid...

A Novel Anti-Polysaccharide Antiserum for Detection of Clostridium difficile Bacteria, and Diagnosis of Clostridium difficile Colonization in Complex Clinical Specimens

JianlingL@tla.arizona.edu — Tue, 24 Jan 2017 06:43:23 GMT

This technology is an antiserum that is highly specific for Clostridium difficile. This target is available on all clinically relevant strains of Clostridium difficile bacteria. Background: Clostridium difficile is a bacteria that causes serious intestinal issues. Each year there are approximately 500,000 cases of Clostridium difficile in the United States, which results in $4 billion in healthcare costs. The key to treating this infection and preventing recurrent infections is early, accurate diagnosis. Unfortunately, individuals with a low quantity of Clostridium difficile or ...

Spark Plasma Joining of Ultra-High Temperature Ceramics without the Use of Filler Materials

JianlingL@tla.arizona.edu — Wed, 07 Dec 2016 12:55:15 GMT

This invention’s approach to solving this problem uses direct current heating to rapidly join two conductive ceramics with seamless joint microstructures. Conventional ceramic joining methods include brazing, transient liquid phase bonding, or mechanical fasteners. Although these methods are widely used and are reliable for most applications, they do have limitations form a production cost and application properties standpoint. These limitations are: 1) extended brazing time period (>4 hours) due to radiative heating methods, 2) inhomogeneous joint microstructures resulting form fill...

Computer-Aided Surgical Trainer (CAST)

JianlingL@tla.arizona.edu — Tue, 06 Dec 2016 13:25:55 GMT

Minimally invasive surgery (MIS) is a modern surgical technique requiring small incisions or no incisions. This technology is a system for the assessment and training of minimally invasive surgical skills (MIS). The apparatus of the invention comprises a set of physical building units, sensors and actuators to embody a variety of training tasks. The sensors gather performance data on real-time, which is processed by a microcontroller and sent to an assessment module. The assessment module classifies the levels of expertise shown by the trainees based on a unique set of performance metrics and...

The "County" Retroreflective Raised Pavement Marker ("County Marker")

JianlingL@tla.arizona.edu — Tue, 06 Dec 2016 09:18:40 GMT

The invention, known as the County Marker, is an innovative variation on the retroreflective raised pavement marker (RRPM). The unique design features two yellow retroreflectors that produce a double yellow signal when viewed at night. The design can serve as a no passing zone line. Background: Standard RRPMs are currently on the outside of the double yellow lines and may be used as a substitute to separate opposite directions of traffic. RRPMs have value in guiding drivers and increasing safety. The Federal Highway Administration has proposed new rules on pavement markings in the Ma...

Converting Ordinary Structures to Smart Structures that Recognize Tap Patterns and Signatures Using Guided Acoustic Waves

JianlingL@tla.arizona.edu — Tue, 06 Dec 2016 08:58:49 GMT

This invention is a device and software to recognize a tap pattern from the connected sensors to perform a specific function. Background: In the age of automation, the demand for increased security measures has greatly increased. This technology aims to provide a secure form of touch sensitive security. For example, users can tap on the door to access their vehicle. The finger tap generates acoustic waves and is captured by the sensors to determine the location. The door is unlocked after a certain pattern is tapped. Applications: Electronic security door locks Smar...

An Individualized Method for Increasing Sleep Time via a Technology Platform

JianlingL@tla.arizona.edu — Thu, 03 Nov 2016 11:24:01 GMT

This technology is a software platform that focuses on sleep efficiency by incorporating individualized, self-correcting methods tailored to improve sleeping habits and increase sleeping time. The platform employs a comfortable, easily accessible wearable technology, and is intended to help adults suffering from lack of sleep to achieve better sleeping habits by tracking their current habits. Background: Approximately 1/3 of American adults suffer from lack of sleep. Lack of sleep can often lead to a multitude of lifelong health issues. Therefore, an individualize...

Risk Model with Predictive Capability Through the Fusion of Experimental/Clinical, Computational, and Imaging Data

JianlingL@tla.arizona.edu — Tue, 25 Oct 2016 17:37:42 GMT

This technology is a novel use of several data sets to improve the predictive ability of risk models. The algorithm analyzes the experimental data set and related outcome as predicted by the computer model, propagates uncertainties to improve prediction, and adds optional imaging information. Background: Risk prediction models are important tools in clinical decision-making. However, risk prediction models can be inaccurate when there are few events compared to predictors, resulting in underestimation in low risk patients and overestimation in high-risk patients. Applic...

Electrostatic Coating with Heavy Metal Nanoparticles by Intrinsic Particle to Surface Interaction

JianlingL@tla.arizona.edu — Tue, 25 Oct 2016 17:15:05 GMT

The technology is a novel electroless deposition technique to form a thin layer of heavy metal on non-traditional substrates such as glass, plastic, and thermal silica. Background: Electroless plating is prominent in engineering to create a homogeneous and uniform coating on complex shaped items to conduct electricity. Coating non-metallic products is more difficult, but substrates such as plastic have the advantage of higher corrosion resistance and lower weight. In addition, electroless plating can be used for aesthetic purposes such as chrome plating on vehicles. Applica...

A Method for Exploiting Preamble Waveforms to Support New Physical-layer Functionalities in Wireless Systems

JianlingL@tla.arizona.edu — Tue, 25 Oct 2016 16:01:34 GMT

This technology is an analog signal processing technique that allows a wireless device to embed user-specific information within the standardized preamble of each transmitted frame. Incorporating information from the physical structure of a wireless system can open up a whole host of possibilities, such as increasing security between two communicating devices. Background: Typically in wireless networks, a user's data is embedded in to the default preamble of wireless systems that are based on orthogonal frequency-division multiplexing (OFDM). The preamble of the p...

POWWER Working Memory and Word Learning Assessment

JianlingL@tla.arizona.edu — Thu, 29 Sep 2016 17:01:14 GMT

The technology is a computerized assessment for word learning and working memory in children that is similar to a game to encourage routine use in children. Background: Working memory plays a vital role in our ability to concentrate, follow instructions, and hold on to information to utilize it. If a child has poor working memory, this can affect word learning, math, and other subject areas. Therefore, a reliable, accurate assessment is necessary to identify children with poor working memory and word learning in order to strengthen these skills early on. Applications: Public schools Pri...

Food Choices for Winning Performance

JianlingL@tla.arizona.edu — Thu, 29 Sep 2016 16:52:59 GMT

The Eat Like a CHAMP program assists athletes and other active students at the University of Arizona with selecting healthier food options that will improve their performance. The "CHAMP" (carbohydrate, hydration, anti-inflammatory, mental focus, and protein) acronym identifies important nutrition information. The program involves a curriculum designed for all incoming freshman and transfer student athletes at the University of Arizona, and is implemented at both the Campus Recreation Center and Bear Down Kitchen (on-campus restaurant). Background: Student athletes may not...

Medication Education, Decision Support, Reminding and Monitoring System (MEDSReM)

JianlingL@tla.arizona.edu — Thu, 29 Sep 2016 16:50:23 GMT

Medication Education, Decision Support, Reminding and Monitoring System (MEDSReM) consists of an app and a companion website that provide individuals with the continuous use of effective strategies that sustain the individual's adherence to antihypertensive medications. Background: With hypertension being the most common chronic disease among older adults, medication adherence is critical in order to avoid hypertension's possible effects, including strokes and end organ damage in the kidneys, retina and brain. Typically only 50% of patients adhere to their medication reg...

Ultra-High Sensitivity Viral Genome Sequencing

JianlingL@tla.arizona.edu — Mon, 26 Sep 2016 11:08:09 GMT

University of Arizona researchers have developed a novel process for rapid genome sequencing of RNA-DNA fragments, even those in archived or damaged biological samples. The process utilizes large panels of primers to amplify short RNA-DNA fragments into separate and off-set pools. These off-set pools of amplicons are used to reconstruct whole and near-whole genomic sequences in samples otherwise deemed non-useful. Background: When performing conventional polymerase chain reaction (PCR) testing for genomic sequencing, some poor-quality biological samples are deemed "negative"...

Non-Recirculating Roller Screw

JianlingL@tla.arizona.edu — Fri, 23 Sep 2016 07:55:50 GMT

This technology was developed as a key element of the camera focusing mechanism for NASA's OSIRIS-REx mission led by the University of Arizona, which was recently launched on a sample retrieval mission to the near-earth asteroid Bennu. This invention meets the demanding requirements of the OSIRIS-REx mission including high precision and reliability as well as low power and has other significant advantages that can be applied to a wide range of commercial applications. Background: Existing precision roller screw products cannot stand up to the demanding requirements for the OSIRI...

IL-18 as a Cardiac Biomarker in Sickle Cell Anemia

JianlingL@tla.arizona.edu — Tue, 19 Jul 2016 16:49:15 GMT

This invention is the use of IL-18 and single nucleotide polymorphism (SNP) associated with it as diagnostic and prognostic markers for myocardial fibrosis, ventricular arrhythmias and sudden death in patients with sickle cell disease. IL-18 is also a potential therapeutic target for preventing sudden death in sickle cell disease patients. Background: Cardiovascular manifestations and sudden death are the top causes of premature death in sickle cell disease patients. These factors contribute to the plateauing of the average life expectancy of these patients in their 40s over the...

Robust and Portable Microresontor Sensor Coupling Design

JianlingL@tla.arizona.edu — Sun, 12 Jun 2016 16:48:05 GMT

This technology is a novel design for an optical coupler that is more robust, easier to fabricate, and not as fragile as a regular coupler. This technology has great potential for portability due to it's robust design and does not require tapered optical fibers with high nano-positioning requirements, making it easier to mass produce. Background: Regular optical resonator sensor systems use fragile optical fibers, which are prone to breakage at the coupler port if not properly cared for, making them non-portable. In addition, current optical coupler designs require tapered o...

Apparatus and Methods for a Software-Controlled Synthetic Phase Mask via Radiance Function Measurement

JianlingL@tla.arizona.edu — Sun, 12 Jun 2016 16:30:47 GMT

This technology measures and uses a radiance function to optimize an optical system to its phase mask. This function does not limit end users to a specific type of phase mask, thus providing the user with more flexibility. In addition, the radiance function data can be processed to emulate any phase mask and therefore works with a mask in an existing system while still producing improved imagery. Background: A common method for extending the depth of field of an optical instrument uses a cubic phase mask placed between the objective lens and the detector. Typical cubic phase masks re...

Smartphone-Based Ophthalmic Examination System

JianlingL@tla.arizona.edu — Fri, 10 Jun 2016 09:55:24 GMT

This patented smartphone-based ophthalmic examination device is coupled with accessories and software applications for ocular diagnosis. This multi-operative device/system possesses many capabilities for preliminary ocular examinations namely; (bio-) microscope or opthalmoscope function, ophthalmic slit-lamp, a pupillometer, fundoscope, scheimpflug camera, and stereo imaging (stereo-photo) device. This device/system is intended to be portable and handheld as well as compatible with telemedicine. Background: Ensuring clinical access to health care requires that mobile approaches be expl...

Cognitive HF Radio with Tuned Compact Antenna

JianlingL@tla.arizona.edu — Tue, 07 Jun 2016 12:52:24 GMT

This invention is a high frequency (HF) radio with a compact and highly configurable antenna with the ability to overcome interference by changes in the ionosphere. This antenna utilizes machine learning and optimization methods to adjust to the environment. Background: Long-distance HF communication relies on ionospheric reflections, especially from the "F" layer. The problem with HF communication is that propagation via the ionosphere can be very unreliable. In addition, within the HF frequency band, different frequencies have different propagation characteristics via th...

Terahertz Transistor

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 17:55:50 GMT

This transistor works in the Terahertz range that modulates the bridge's conductivity in a nonlinear manner. It is a likely candidate for replacing silicon in superconducting transistors running at higher frequencies without the heating and power issues of silicon as well as advantages over III-V and spintronic technologies with both of these issues. Background: The Terahertz operation of mainstream silicon CMOS technology is very challenging from the perspective of power consumption and fabrication techniques as Moore's law pushes technology forward. Now, High Electron Mobil...

Reworkable UV Curable Thermosets based on 7-Glycidyloxycoumarin

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 13:38:18 GMT

This invention describes a reversible thermoset that is cured by a particular set of ultraviolet waves and degraded by a different set of ultraviolet waves. The resin's ability to be re-used makes it a dynamic choice for adhesive and structural needs. Background: Epoxy, a thermosetting resin, is an adhesive compound that is hardened by a variety of methods, the most common of which is heat. These thermosets are positioned and then "cured," or hardened into place, creating sturdy and durable adhesion. Unfortunately the permanency of these resins leaves little r...

Pyridazine and Pyridazinone based Polymer Foams as Filtration Materials for Removal of Nucleophilic and Electrophilic

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 13:00:19 GMT

This technology is the synthesis of a porous and sponge-like polymer foam that is capable of removing harmful substances such as chemical warfare agents, metals, and CO2. In addition, the material changes changes color when a reaction with a nucleophilic species occurs. Background: Using a Carboni-Lindsey reaction, Pyridazine and Pyridazinone based foams can be synthesized. These foams are effective in removing both nucloephilic and electrophilic chemicals and metals. Applications: Water and chemical warfare filtration systems Odor control Mine safety Respiratory ...

Solvent-Free and Additive-Free Nitration of Arenes

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 12:18:44 GMT

University of Arizona researchers have developed a novel, one-step, catalyst-free, and solvent-free synthetic process for the nitration of aromatic compounds. This method has been used to prepare 2,4-dinitroanisole, an alternative to trinitrotoluene (TNT), as an ingredient in melt-cast explosive formulations; and dinitrophenyl ethers. This synthetic process can be utilized to produce a variety of nitroaromatic compounds in a fast, straightforward, and more economical fashion than traditional chemical methods. Background: Traditional synthetic nitration methods often employ catalysts,...

Powdered G-protein Coupled Receptors

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 12:14:25 GMT

Inventors at the University of Arizona have generated G-protein coupled receptors (GPCRs) lypophilized (freeze-dried) into powdered form. When thawed and rehydrated, these GPCRs retain the functionality of their pre-frozen state even after one year. Because this process also involves the removal of water, the inventors were able to produce thawed GPCRs with specific hydration levels. This appears to be a useful preservation method for GPCRs as well as a way to generate GPCRs with specific concentrations of water (or, as the inventors demonstrated, deuterium) for research purposes. Ba...

Pseudoprolines in Neuropeptides

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 12:13:59 GMT

This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects. Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides, however, glycosylation plays a key role in manipulating the structure of existing peptides. This invention uses glycosylation to create a newly folded peptide that can then be used in a variety of pharmaceutical applications to produc...

Improvements in Inverse Vulcanization of Sulfur

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 11:55:21 GMT

This invention describes a faster and more efficient method of polymerizing sulfur with various copolymers to increase the structural stability and electrochemistry of the resulting polymer compound. In addition, this technology is able to to confer additional properties for use in battery production. Background: Sulfur vulcanization is used to strengthen existing polymer compounds. Researchers at the University of Arizona set out to improve the structural features of existing sulfur copolymers prepared via inverse vulcanization. Throughout their research, they sought to prepare poly...

Polyarylenes by Cycloaddition Polymerization of Tetrazines and Pyridazines

JianlingL@tla.arizona.edu — Wed, 01 Jun 2016 11:52:34 GMT

University of Arizona researchers have developed a novel method of producing a variety of polyarylene compounds in order to increase efficient production of high quality membranes. Background: Traditional means of producing high quality membranes are laborious due to the use of reagents involved in the process. In order to remove this burden, University of Arizona researchers have developed a means of quickly producing a wide variety of high quality membranes. Applications: Solid oxide fuel cell membrane production Lithium ion battery conductor production Generali...

Polarization Plenoptic Imaging System and Application to 3D Reconstruction

JianlingL@tla.arizona.edu — Wed, 11 May 2016 09:55:39 GMT

Researchers at the University of Arizona have designed a polarization plenoptic camera that can record position, angle, wavelength, polarization and time, all in a single shot. Because of the novel application of polarizers, it can separate reflected light from transmitted light for a given surface, enable imaging of objects that are not in the direct line of sight or are occluded by turbulent media, and improve the signal to noise ration, without blur. Applications include 3D reconstruction, material property identification of objects, and reconnaissance. Background:...

Side-Strapped Phthalocyanines as Materials for Organic Electronics

JianlingL@tla.arizona.edu — Fri, 06 May 2016 15:48:06 GMT

This invention describes a novel side-strapped derivative of phthalocyanine for use in photovoltaic cells to generate a current in a more efficient manner. Background: Within the context of photovoltaic solar power, there are other compounds based on the phthalocyanine structure that are in use currently. These other compounds have an energy conversion of 11% at their highest. The variations of the core molecule come chiefly from the different metals places in the complex onto it, including: copper, aluminum, and palladium. Applications: Use in a photovoltaic c...

Real Analysis Math Education App

JianlingL@tla.arizona.edu — Wed, 04 May 2016 14:53:24 GMT

Inventors at the University of Arizona have developed an application that delivers lessons on mathematical concepts to students enrolled in a real analysis mathematics course. The application includes lesson overviews, graphs that can be manipulated by users, and true/false questions to reinforce learning experiences. The app can be updated and refined to incorporate the feedback of the students. Background: With the use of smartphones becoming ubiquitous, there is a need to leverage these devices as a platform to provide learning experiences for students. In addition, over 6.7 mil...

Sweat Biomarkers as an Indication of Physiological Conditions

JianlingL@tla.arizona.edu — Tue, 03 May 2016 13:38:15 GMT

Inventors at the University of Arizona have devised a means by which cortisol isomer ratios in human sweat can be measured and used to evaluate the physiological or psychological state of the patient. Certain cortisol isomer ratios are associated with particular conditions or disorders (high blood pressure, sleep disruption, and others). Other ratios are associated with states of stress or relaxation. Background: Researchers at the University of Arizona have identified that there are different isomers of cortisol found in human sweat, and that the concentration ratios between standar...

Santa Rita and Canelo Germplasms of Sprucetop Grama and Taber Germplasm of Curly Mesquite

JianlingL@tla.arizona.edu — Wed, 13 Apr 2016 15:48:15 GMT

Professors at the University of Arizona have invented several varieties of turfgrass designed to grow under low-maintenance conditions. The inventions were derived from specimens of two classes of sprucetop grama (Santa Rita and Canelo), as well as one class of curly mesquite grasses (Taber). They require low amounts of water and fertilizer, are tolerant of pests and mowing, and were selected based on their appearance and other characteristics associated with turf utility. In addition to the germplasms (seeds or other material used to generate the plants), the invention encompasses the genes ...

Cell Cycle Nucleic Acids, Polypeptides and Uses Thereof - Wee1

JianlingL@tla.arizona.edu — Wed, 13 Apr 2016 13:55:52 GMT

This invention improves transformation frequency by changing levels of protein expression in the target cells, altering the cell cycle, specifically by modulating the activity of a gene known as RB3 which influences the cell's progression from G1 to S phase in the cell cycle. Overexpression of RB3 can be induced through existing methods of transient transfection and will delay progression from G1 to S. Conversely decreasing the activity of RB3 through antibodies or antisense oligonucleotides will stimulate cell division. Background: The insertion of various genes (transformation) int...

Smart Textile to Predict Diabetic Foot Ulcer

JianlingL@tla.arizona.edu — Tue, 05 Apr 2016 16:17:06 GMT

This invention is a movable, washable smart textile that can measure abnormalities in pressure and temperature when a patient walks on it. The textile can analyze the data and send alerts to the patient when abnormalities suggest the presence of diabetic foot ulcers (DFU) and/or the likelihood of falls or other injuries. Background: Demand for new methods of detecting diabetic foot ulcers is high since the development of new treatments has stalled since the late 1990s. Currently one in four patients with diabetic ulcers will require a foot amputation. This extremely serious...

Prostate Cancer Patient Blood Sample Collection and PSA Survey

JianlingL@tla.arizona.edu — Tue, 05 Apr 2016 16:07:39 GMT

Blood samples collected from participants in the NIH-funded Watchful Waiting Study, a study of selenium supplementation in men with prostate cancer. Samples were processed to prepare plasma and tested for Prostate Specific Antigen (PSA) level. Samples are available for licensing.

Precise, Accurate Bacterial Identification System

JianlingL@tla.arizona.edu — Tue, 05 Apr 2016 15:37:00 GMT

This technology is a rapid, whole genome sequence analysis tool to determine the type of bacteria, resistance, and virulence that lacks biases introduced by culture-based methods. Background: The lack of accurate and precise methods to identify bacteria forces clinicians to use broad based antibiotic regimens. Unfortunately, only 20-40% of samples are diagnosed correctly with current methods. Use of these broad based antibiotic regimens can increase the rise of antibiotic resistance. For example, in diabetic foot ulcers, the microbial community is diverse and difficult for a cl...

Resurrecting PAGEPLOT for Tree-ring Analysis

JianlingL@tla.arizona.edu — Mon, 28 Mar 2016 15:56:48 GMT

This technology is software used for crossdating tree rings using skeleton plotting, allowing more accurate dating than ring counting alone. Background: Ensuring accurate dating by counting each individual tree ring can prove difficult due to calendar year vs. time to grow a ring, absent rings, false rings, and other various factors. Matching ring-growth characteristics across many samples to crossdate rings allows the exact year of each ring to be identified. This software, while still in development, focuses on modernizing outdated skeleton plotting and mainframe software so that the...

Method for Determining Cell Stiffness

JianlingL@tla.arizona.edu — Mon, 28 Mar 2016 10:15:52 GMT

This invention is a minimal-contact method used to trap and measure the stiffness of platelets in relation to the whole cell. Background: Platelets, essential for hemostasis, are easily activated via biochemical and mechanical stimuli. In addition, cell stiffness is a vital parameter modulating the mechano-transduction of exogenous mechanical stimuli. This methodology seeks to address the gap in approaches of measuring individual platelet stiffness without inadvertent platelet activation. Applications: Hospital assessments (measuring cell stiffness) Forensic medicine (determining ...

Brief Health Behavior Change Intervention Training Program for Health Professionals

JianlingL@tla.arizona.edu — Mon, 28 Mar 2016 09:24:43 GMT

This invention is an in-person workshop and website that provides information and training for “helpers” and complementary and alternative medicine (CAM) practitioners to better help individuals to change harmful health behaviors, including tobacco cessation. Training focuses on “helping conversations” that avoid confrontation and emphasize intervention on the part of individuals’ social networks and the special training and backgrounds associated with CAM. Background: Some behavior cessation programs tend to underutilize the power of social networks. A...

Reactive Oxygen Species Gene Signature Predicts Survival in Sepsis

JianlingL@tla.arizona.edu — Tue, 15 Mar 2016 10:22:16 GMT

This technology is a 21-gene reactive oxygen species (ROS)-associated molecular signature that predicts survival in septic patients. This particular signature has outperformed randomly generated signatures of the same signature gene size. This signature is easily assayed from peripheral blood and can potentially predict. Background: There is a significant amount of evidence that oxidative stress plays a large role in pathogenesis of sepsis-associated multiple organ failure. Sepsis-related multiple organ dysfunction syndrome leads to a large number of deaths in intensive care unit...

Metamaterials with Gain Compensation by Active Devices

JianlingL@tla.arizona.edu — Tue, 08 Mar 2016 15:31:57 GMT

This invention is an effective gain medium that overcompensates for the loss of a conventional passive metamaterial, meanwhile keeping its original negative-index property. This material can be used to solve the critical challenge current metamaterial technology faces in practical applications. Background: Using energy conservation-based theory, full-wave simulation and experimental measurement, the inventors have shown that a fabricated sample consisting of conventional sub-wavelength building blocks with embedded microwave tunnel diodes exhibits a band-limited Lorentzian dispersion...

Tunability of the Phase in Quantum-Like Mechanical Elastic Systems

JianlingL@tla.arizona.edu — Tue, 08 Mar 2016 15:25:22 GMT

This technology is an approach that gives the user the ability to tune phononic crystals and acoustic metamaterials to have specific quantum computing properties. Background: Metamaterials, artificially fabricated materials in which small structures can be arranged within a material in order, can give said material new properties that are not inherent to the original material. This technology capitalizes on the ability to tune these materials and is the product of discovering the analogy between classical mechanical systems and quantum and electromagnetic phenomena. Applicat...

High Power Semiconductor Pulsed Laser System and Method

JianlingL@tla.arizona.edu — Sat, 05 Mar 2016 13:58:19 GMT

This invention is a pulsed semiconductor light emitter than can be pumped over much longer durations than the emission time, using charge separation in a gain medium to manipulate the carrier lifetimes. Carrier generation powers can be reduced, and/or carrier generation can be extended to minimize the pumping power constraints for a given output peak power. Background: Although semiconductor lasers can be designed to emit light from the UV to the infrared. However, they are not generally used for high peak power because the carrier recombination lifetimes in semicond...

Expansible Ascending Aortic Graft

JianlingL@tla.arizona.edu — Thu, 25 Feb 2016 07:51:15 GMT

This technology offers an expansible ascending aortic graft that allows for gradual expansion in systole and recoil in diastole, reducing blow flow turbulence and low-flow areas. Background: Patients who suffer from senile aortic valve stenosis often require aortic valve replacement. In many patients, concomitant aneurysmal disease requires the removal and replacement of the ascending aorta. Currently, the ascending aorta is often replaced with vascular grafts made of Dacron or poly-tetra-fluro-ethylene (PTFE). Despite their flexibility, these grafts have minimal compliance, leading ...

Reactive, Fluorescent Epoxy Monomers for Making Epoxy Thermosets Visible Under Ultraviolet Light

JianlingL@tla.arizona.edu — Mon, 22 Feb 2016 22:14:36 GMT

This technology allows for the easy identification of epoxy repairs using ultraviolet (UV) light. A fluorescent dye is covalently bonded to the epoxy group molecule, preventing it from leaching out of the cured adhesive. This dye, which emits a bright fluorescence under UV light, does not reduce the adhesive strength of the epoxy and will not lose its fluorescence over time. In addition, only very small concentrations of the incorporated dye are needed to provide a high amount of fluorescence under ultraviolet light. Background: Identifying previous repair work is important for field...

Phase Change Nanodroplet - Liposome Conjugates for Enhanced Drug Delivery

JianlingL@tla.arizona.edu — Wed, 10 Feb 2016 08:13:21 GMT

This technology utilizes phase-change nanodroplet-liposome conjugates to achieve targeted drug delivery of oncology therapeutics. The technology uses ultrasound to convert the nanodroplet into a gas, whereby this cavitation of the nanoparticles cases stress on the tight junction areas of the brain. The cavitation will temporarily make the blood-brain barrier more permeable, allowing the nanoparticles and their conjugated drug-payloads to cross the blood-brain barrier to the diseased brain tissue. Background: Blood-brain barrier (BBB) technology is a set of scientific techniques...

Biostable Segmented Elastomers and Engineering Thermoplastics

JianlingL@tla.arizona.edu — Mon, 08 Feb 2016 11:06:47 GMT

This invention involves the creation of novel, segmented polysulfone compositions, which consist of both hard and soft segments. These polysulfone compositions demonstrate a high degree of toughness and other useful elastomeric properties are biocompatible, and resistant to biodegradation. Further, the ratios of “hard” to “soft” segments are adjustable, allowing for the creation of customized, application-specific compositions with tailored elastomeric and chemical properties. Background: A continuing need exists for biostable, tough elastomers, particularly f...

eHIP - the eHealth & Intervention Platform

JianlingL@tla.arizona.edu — Mon, 25 Jan 2016 13:14:29 GMT

Inventors from the University of Arizona Bio Computing Facility have developed eHIP (eHealth & Intervention Platform), an adaptable “software as a service” platform that serves to provide researchers and healthcare professionals with a framework for building web and mobile device-oriented research projects or interventions. Included in this platform are communication features (including text, voice, and video messaging systems), data collection, and web-based forms. These features can be modified, or built from scratch, to suit the specific needs of any project. This&...

Easy Writing: A Beginning Writer's Workbook

JianlingL@tla.arizona.edu — Thu, 21 Jan 2016 14:11:29 GMT

Easy Writing: A Beginning Writer's Workbook is a useful too for ESL educators. It is a writing ESL workbook that helps low proficiency English language learners develop basic writing skills. Students learn basic grammar and vocabulary through practice while writing simple paragraphs.

HLA Exposure Tool

JianlingL@tla.arizona.edu — Wed, 20 Jan 2016 15:33:27 GMT

Researchers at the University of Arizona have developed an interferometer that operates at 121.6 nm, wherein the sample is outside the vacuum and only the source itself is enclosed in a vacuum. This allows the instrument to be used in lithography without the need to create a large vacuum chamber to hold the sample and instrument during writing or inspection. Non-destructive optical inspection techniques become viable with very high resolution and no need for a high vacuum. Background: Optical microscopes and interferometry are useful in life sciences, physical scie...

Technology for Building Capacitors Using Templates with Nano Scale Pores

JianlingL@tla.arizona.edu — Tue, 12 Jan 2016 11:13:58 GMT

Volumetric Segmentation of Cardiac Images

JianlingL@tla.arizona.edu — Mon, 11 Jan 2016 10:14:07 GMT

This invention is a semi-automated segmentation method and system which significantly reduces the amount of time and expertise required by an operator and also improves accuracy and repeatability. While the inventors have implemented this approach specifically for segmentation of right ventricles in 4D images, this invention is adaptable to a wide range of other medical imaging and other application areas. The user only selects a few landmarks, rather than entire contours, and then the remaining segmentation and related analytics are performed automatically. By minimizing user input and ...

Plastic Crystal Modified Nano-Wire Ultra Capacitor (NUC)

JianlingL@tla.arizona.edu — Wed, 18 Nov 2015 15:13:45 GMT

This invention involves the addition of plastic crystals to the dielectric material of a nanowire ultracapacitor (NUC). An existing NUC design was developed by the University of Arizona in conjunction with the University of California, Irvine. Addition of the plastic crystals serves as an optimization to the existing design by increasing the NUC’s capacitance and subsequently, its energy density. Background: UArizona researchers have determined that the addition of plastic crystals (i.e. eutectic salts) can increase the energy density of a capacitor by in...

Compact Multiband Mobile Phone Antennas for LTE Operations

JianlingL@tla.arizona.edu — Wed, 18 Nov 2015 12:52:27 GMT

This invention is an antenna that can be used in hardware configurable mobile devices and is compatible with installation on a metal endoskeleton. Background: The research for this technology has been trying to find an antenna that is compatible with the new customizable modular mobile devices but can still transmit and receive despite being attached to a grounded metal endoskeleton. Another research goal is to find a versatile design that will be compatible with all commercial radio wave transmission bands. Applications: Ara phone; other customizable...

A New Framework for Comprehensive, Robust, and Efficient Global Sensitivity Analysis

JianlingL@tla.arizona.edu — Wed, 18 Nov 2015 09:39:48 GMT

Variogram Analysis of Response Surfaces (VARS) is a novel framework for global sensitivity analysis which provides more reliable and efficient results for high dimensional models. Background: VARS has been demonstrated as a general purpose framework that incorporates known approaches as special purpose cases. VARS is up to 100 times more efficient than traditional approaches for high dimensional systems while more reliably exploring large multi-variate models at different scales. While originally developed for complex hydrology and environmental models, VARS can be applied to im...

Framework for Global Sensitivity Analysis

JianlingL@tla.arizona.edu — Wed, 18 Nov 2015 09:39:27 GMT

Framework for More Effective and Efficient Global Sensitivity Analysis

JianlingL@tla.arizona.edu — Fri, 13 Nov 2015 11:00:16 GMT

Glycosylation of Secretin Peptides to Improve Drug-Like Properties

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:31:18 GMT

This invention is the development of pituitary adenylate cyclase activating peptide (PACAP) agonists for neuroprotection and antagonists for migraine. Background: PACAP is known as a neuronal survival factor, regulating the development, maintenance, function, and plasticity of neurons through activating PAC1, VPAC1, and VPAC2 receptors. Glycosylated PACAP analogues have been found to penetrate the blood-brain barrier (BBB) at a high rate. In addition, VPAC1/2 receptors are involved in vasodilation and may contribute to migraine attacks. It is possible to treat these migraine at...

Color-Free, Thermally Reworkable Diels-Alder Epoxies with Liquid Precursors

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:30:09 GMT

Researchers at the University of Arizona have developed an epoxy which reverts to a liquid upon application of heat. This epoxy is colorless and contains liquid precursors, which can be mixed at room temperature, making it an ideal adhesive for art conservation. This invention solves the issue of irreversibility in epoxy adhesives. Background: Epoxies are desirable materials because of their high strength and resistance to temperature and humidity fluctuations, but cannot be removed after cure. Issues with previously synthesized, thermally reversible epoxies include high viscosity, ...

A Green Alternative to Polyurethane

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:29:10 GMT

Fluorogenic Diazonium-Derived Fluorophores

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:28:08 GMT

This technology describes various diazonium salts that can react to produce a fluorescent azobenzene compound. Background: Current iterations of fluorescent diazonium salts utilize metal catalysts to produce a reaction. However, these metal catalysts can have harmful effects in a medical setting. This invention consists of a bioorthogonal approach performed under physiological conditions to produce fluorescent compounds that can be bound to specifically targeted proteins. Applications: Biosensors Detection and diagnostics Medical imaging Advantages: Ideal for medical...

Novel Method for Synthesis of Indoles

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:17:58 GMT

This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner. Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. This invention possesses no such drawbacks and creates heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds. Applications: Anti-HIV...

Annulation to Produce Heterocyclic Compounds

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:16:59 GMT

This invention describes a novel way to generate heterocyclic compounds via a 3+2 annulation. This method requires no expensive reagents, and can be done in a chiral manner in some instances. Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. The invention possess no such drawbacks and is able to create heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds. Applications: Can be used to synthesize a variety ...

Releasable Triazabutadienes

JianlingL@tla.arizona.edu — Fri, 30 Oct 2015 11:13:47 GMT

This invention is a chemical means of protecting triazylbutadienes from degradation in acidic conditions. When exposed to a predetermined specific enzyme, the system can release triazylbutadiene. Triazylbutadienes can then go on to release aryl diazonium. This aryl species can be apart of various coupling reactions. This invention has the potential to increase the durability of nanotechnology-based biosensors through its ability to aid in the production of aryl diazonium even under acidic conditions. Background: A biosensor is any device that transforms chemical information int...

Methods for Securing Wireless Communications at the Physical Layer

JianlingL@tla.arizona.edu — Wed, 28 Oct 2015 13:34:09 GMT

This invention is a method that enables users to obfuscate their transmission patterns by intelligently producing friendly jamming at the transmitter end, a technique that prevents low level eavesdropping. Background: In a world dominated by ever-developing technology, the demand for reliable digital security measures is increasingly prevalent. When securing communications at the software level, like most current security schemes, it became apparent that prevention of eavesdropping may show a stronger performance at the hardware level. Using a multiple input and multiple output...

Control of Boundary-Layer Transition for Hypersonic Flight

JianlingL@tla.arizona.edu — Wed, 28 Oct 2015 13:33:56 GMT

This invention provides techniques to control the nonlinear phase transition of laminar-turbulent flow in hypersonic boundary layers while reducing negative effects on the vehicle while in the transition region. Background: Generally, there is a large amount of friction and heat transfer during transition, which can compromise multiple aspects of the vehicle experiencing these hypersonic speeds. Based on the physics of laminar-turbulent transition in hypersonic boundary layers, this invention seeks to address this issue. It was found that the nonlinear transition region was extended in...

Smartphone-Based Handheld Ophthalmic Examination Device

JianlingL@tla.arizona.edu — Mon, 12 Oct 2015 09:00:41 GMT

Researchers at the University of Arizona have developed a comprehensive ophthalmic system with a handheld smartphone-based examination device for ocular diagnosis that uniquely monitors of both eyes to detect disease, drug use or fatigue. This multi-operative device/system possesses many capabilities for preliminary ocular examinations namely; (bio-) microscope or ophthalmoscope function, ophthalmic slit-lamp, a pupillometer, fundoscope, scheimpflug camera, and stereo imaging (stereo-photo) device. This invention is a portable, hand-held, device/system that is compatible with medicine-related...

Using Quantum-Like Behavior of Elastic-Waves for Quantum Computing Using Phi-Bits

JianlingL@tla.arizona.edu — Wed, 07 Oct 2015 11:07:53 GMT

This technology describes a method in which phonons can be manipulated for use in encoding information, for use with quantum computing-type algorithms. Rather than qubits, this method produces φ-bits, which are achieved through operating on the phonon wave phase. Such control results from fermion-like behavior of phonons, thus allowing for utilization in numerous computing platforms. Background: Phonons are known to display boson characteristics in the sense that there is no restriction on the number of “particles” which can occupy the same quantum state. This invent...

Small Molecular Weight Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy

JianlingL@tla.arizona.edu — Fri, 11 Sep 2015 16:57:03 GMT

This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. Investigators found compounds that may disrupt the Ku70/80 – DNA repair association. The Ku70/80 dimer protein is involved in the repair of radiation-induced DNA double strand breaks (DSBs) in human and mammalian cells. These Ku70/80-DNA association inhibitors synergistically sensitized human cancer cells to radiation treatment at sub-cytotoxic concentrations. Background: Each year, over 700,...

Methods for Identifying, Diagnosing, and Predicting Survival of Lymphomas

JianlingL@tla.arizona.edu — Thu, 10 Sep 2015 12:59:08 GMT

This invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be ...

Mouse Model of Human Asthma and Allergy

JianlingL@tla.arizona.edu — Thu, 10 Sep 2015 12:57:45 GMT

This technology is a collection of transgenic mouse lines that contain a human gene locus (TH2) that is involved in human asthma and allergy. This gene locus includes the Rad50, IL-13, and IL-4 genes. The first in the series of mouse lines contains wild-type locus of the genes. The second mouse line contains a series of polymorphisms that are found in human asthma & allergy.

An In Vitro Cellular Bioassay for Assessment and Investigation of Neurotoxicity

JianlingL@tla.arizona.edu — Thu, 10 Sep 2015 12:55:43 GMT

This invention provides high speed, low cost, and highly accurate neurotoxicity and developmental neurotoxicity screening methods for a wide variety of compounds. Background: Neurotoxicity tests are designed to generate definitive data concerning the adverse effects of a neurotoxic substance on human or animal health or the environment. Neurotoxicity tests examine chemically induced adverse effects on the brain, spinal cord and/or peripheral nervous system. An assay capable of identifying neurotoxic compounds with sufficient accuracy to rule out the need for further animal testi...

EpiGro

JianlingL@tla.arizona.edu — Thu, 10 Sep 2015 11:28:07 GMT

This software models and predicts epidemic case counts. It has an easy-to-use graphical user interface (GUI), and its most recent version, EpiCovDA, is currently being used to contribute to the CDC's COVID-19 modeling efforts and the COVID-19 Forecast hub. The open source software download is available at https://jocelinelega.github.io/EpiGro/. Background: This software uses a simple mathematical model that allows users to model and forecast outbreaks, including those related to vector-borne diseases. It was developed as a predictive tool for the recent outbreak of c...

Lipid Membranes Enabling MALDI-TOF Mass Spectrometry Protein Analysis

JianlingL@tla.arizona.edu — Thu, 03 Sep 2015 13:44:56 GMT

This technology is the use of planar supported lipid bilayer to create the stability for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) analysis. Background: MALDI-TOF is an effective method to detect biological analytes from complex samples. MALDI-TOF MS is effective to extract biological analytes by label-free detection and identification. Unfortunately, these proteins bind to membrane-associated receptors, making it incompatible for MALDI-TOF MS with artificial lipid membranes. Cross-linking polymerization of planar suppor...

Computer Assisted Surgical Trainer - Portable Version (CAST-PV)

JianlingL@tla.arizona.edu — Thu, 03 Sep 2015 11:10:52 GMT

This technology is a construction kit that allows users to build a minimally invasive surgical (MIS) box trainer that provides a range of skills training. The trainer is portable, affordable and provides performance assessment software that can be downloaded to smart tablets and phones. Made with Lego Mindstorms, CAST-PV allows users to design training instruments and tasks for their own specified training purposes. Users can use this technology to train for specific procedures and be assessed for their performance. Background: Medical simulation is an interactive training and feedback meth...

BlueTIME - Bluetooth-based Travel Information Monitoring and Evaluation System

JianlingL@tla.arizona.edu — Wed, 02 Sep 2015 15:19:37 GMT

BlueTIME (Bluetooth-Based Travel Information Monitoring and Evaluation System) is a low cost, integrated system for roadway travel time detection, traffic state monitoring, and performance evaluation. BlueTIME detects anonymous MAC addresses from all Bluetooth devices within range (e.g., phones, vehicular Bluetooth systems, headsets, and music players). The system provides online information to traffic engineers, researchers, and the public for their respective needs. Background: BlueTIME provides both real-time and historical traffic information. Users can access a specific website to...

Using Electroluminance Technologies To Visually Indicate Building Structure Integrity

JianlingL@tla.arizona.edu — Wed, 02 Sep 2015 15:18:45 GMT

This technology addresses the issue of non-trained individuals to be able to monitor the integrity of a building. This is done by connecting a sensor to a circuit board that relays the information to an electroluminescent display module. Background: Electroluminescence is the process of applying voltage to a material until it illuminates with color. There are pre-existing sensors that measure the integrity of buildings by applying current, pressure, or ultra-sonic waves. These signals can be sent to a display for visual inspection of the test structure. Applications: ...

Natural Antimicrobial Plant Wash Formulation

JianlingL@tla.arizona.edu — Thu, 13 Aug 2015 08:20:58 GMT

This invention is an antimicrobial wash for use in post-harvest treatment of produce. The antimicrobial plant wash is a blend of essential oils and plant extracts that are Generally Recognized As Safe ingredients (GRAS). Background: Post-harvest treatment is currently conducted with chemical sanitizers to control microbial contamination on organic produce. Chlorine is a common chemical sanitizer used, but it is known to form carcinogenic compounds such as trihalomethane. The invention utilizes energy and environmentally friendly plant antimicrobials for use in the organic fresh...

Electrostatic Application of Antimicrobials

JianlingL@tla.arizona.edu — Thu, 13 Aug 2015 08:16:41 GMT

These liquid and powder sprays use antimicrobials extracted from plants and other natural sources to inhibit the growth of foodborne pathogens in meat products. This natural method is both effective and efficient while addressing the current issues associated with chemical-based food sanitizers including consumer health and cost. Background: The innovators have used various natural antimicrobials in powder or liquid spray form on beef, pork, and chicken products. The meats were inoculated with foodborne pathogens, treated with the natural antimicrobial sprays, and stored at refriger...

Aflatoxin-Free Crops

JianlingL@tla.arizona.edu — Thu, 13 Aug 2015 08:14:03 GMT

This patented invention is a method of eliminating or substantially reducing aflatoxin in crops by inhibiting Aspergillus fungus, a biosynthetic precursor to aflatoxin. By inhibiting the primary elements of aflatoxin’s biosynthetic pathway, aflatoxin can be eliminated altogether. Background: The inventor has conducted successful experiments using this RNA interference technique on T2 maize plants. The transgenic plants infected with Aspergillus strains showed either significantly lower aflatoxin levels than control groups or had so little aflatoxin that it was undetectable. &nbs...

Design and Synthesis of a New Class of G-Quadruplex Binding Ligands for the Treatment of Cancer

JianlingL@tla.arizona.edu — Thu, 30 Jul 2015 15:11:26 GMT

This technology identifies new chemical entities (NCEs) that, according to FRET assay, target the G-quadruplex secondary DNA structure. The disclosed NCEs possess structural features with side chains that may improve potency with specificity over previously reported c-Myc suppressors. The Hurley lab previously discovered that stabilization of a specific G-quadruplex structure formed in the c-MYC promoter region functions as a transcriptional repressor element. c-Myc has also been implicated in progression of arterial disease (proliferation of atherosclerotic plaques). Thus ...

Minimally Invasive Percutaneous Guide for Hip Fracture Fixation

JianlingL@tla.arizona.edu — Thu, 16 Jul 2015 11:16:14 GMT

The invention is a design for a minimally invasive percutaneous guide for pin placement used in hip fracture fixation. This guide is placed on the thigh but rigidly affixed to the femur, providing a stable platform for pin placement. The guide enables independent control of position and rotation on both anterior/ posterior and lateral fluoroscopy, allowing steady progress through the operation. Background: Hip fractures, common in the elderly, are typically treated with indirect reduction and percutaneous fixation. Correct placement of the fixation device depends on accurate...

Absolute Calibration of Slope Measuring Tests

JianlingL@tla.arizona.edu — Sat, 27 Jun 2015 13:58:28 GMT

Researchers at the University of Arizona have developed a system for testing the figure and finish of optical surfaces or any other curved surface using a Shack-Hartmann type of method, wherein a pattern can be projected onto the surface and then its returned image can be analyzed. The patterns can be varied to optimize the returned information regarding slope details of a variety of shapes. The SCOTS technology can be used on a rough surface as well as on the nearly-finished surface. Background: Testing of aspheric and freeform surfaces can be challenging at best using conve...

Non-Regularized Direct Superresolusion for Realistic Image Reconstruction

JianlingL@tla.arizona.edu — Wed, 10 Jun 2015 16:09:57 GMT

Researchers at the University of Arizona have developed a super-resolution (SR) technique that creates sharper images from low-quality or small cameras without fabricating the details. The novel technique applies motion to multiple images and then uses a non-regularized algorithm that directly solves a fully-characterized multi-shift imaging system to grant realistic restorations with physically accurate high resolution. Background: Currently known SR techniques employ optimized priors and regularizers to deliver stable appealing restorations even though they deviate from ...

New Therapy to Prevent Venom Induced Coagulopathy

JianlingL@tla.arizona.edu — Mon, 01 Jun 2015 12:26:12 GMT

This invention is the use of iron and carbon monoxide to increase clot formation after venomous snake bite. Venom exposure impairs the blood’s ability to clot. Serious complications may result in life threatening hemorrhage. This new therapy can be used as a bridging therapy between when the snake bite occurs and when the anti-venom can be given at the hospital. Background: Venomous snake bites are the greatest cause of human injury and fatality from venomous animals. Venom-induced coagulopathy is one of the common results from snake bites. Toxins deactivate the clotting ...

Human Delta Opioid Receptor cDNA

JianlingL@tla.arizona.edu — Tue, 19 May 2015 14:44:20 GMT

A cDNA clone containing the entire open reading fame of a human delta opioid receptor. Background: The delta opioid receptor is an important target for drug development. Testing drugs for activity at human delta opioid receptors requires access to appropriate tissue, which is generally unavailable. This technology enables bioactivity studies at this receptor without the tissue requirement. Advantages: Receptor bioactivity studies Applications: Drug characterization Medical Applications

A Microfluidic System for Automated Dissociation of Tissue

JianlingL@tla.arizona.edu — Wed, 13 May 2015 14:52:39 GMT

This invention is an automated system with the ability to dissociate a variety of soft biological tissues, such as those found in the heart or central nervous system, into viable single cells for culture preparation and other various uses. It includes a microfluidic device made from clear, low-cost, biocompatible materials integrated with imaging and a flow control system. The invention dissociates tissue samples into single cells in a quick and reliable manner. Background: For decades, manual trituration using micropipettes has been the standard method by which single neurons are i...

Hybridoma Clones and Monoclonal Antibodies to ING4

JianlingL@tla.arizona.edu — Wed, 13 May 2015 14:41:14 GMT

This invention is directed to a monoclonal antibody that recognizes human ING4 in its native form. The invention is also directed to a hybridoma cell line that produces the monoclonal antibody, and to methods of diagnosing cancer using the antibody. Background: ING4 is a member of the ING tumor suppressor family and has been shown to play a role in many cancer-related cellular processes, including, cell proliferation, apoptosis, migration, angiogenesis, contact inhibition, DNA damage response, and hypoxia. Gene deletion or reduced expression of ING4 has been reported in v...

Dyzo- Piezo Electric System for Measuring Tissue Properties

JianlingL@tla.arizona.edu — Wed, 13 May 2015 14:40:30 GMT

This patented device is a flexible sensor capable of conforming to the skin of a patient to record data relevant to overall skin health. Background: The device tracks the variable elastic modulus between healthy and unhealthy skin. This can determine efficacy of beauty products that claim to deliver healthier skin to users or even detect malignant tumors non-invasively. Also capable of computing spatial maps for skin lesions over a large area. Applications: Non-invasive tumor detection Progressive tumor tracking Spatial mapping of large skin lesions Cosmetic efficacy ...

Bidirectional Mode-locked Fiber Laser for Dual Comb Spectroscopy

JianlingL@tla.arizona.edu — Sun, 10 May 2015 15:41:07 GMT

Researchers at the University of Arizona have developed a free-running bidirectional mode-locked fiber laser operating at telecommunications wavelengths. Two coherent femtosecond frequency combs are generated from a single laser cavity to ensure mutual coherent properties and common noise cancellation. Background: Optical frequency combs (OFCs) are useful for many application because of the fact that thousands of highly coherent optical frequencies are accurately and precisely defined with only two degrees of freedom. Currently, OFCs are very expensive and difficult to build...

Edible Films Containing Plant Antimicrobials Inactivate Salmonella Newport on Organic Leafy Greens

JianlingL@tla.arizona.edu — Thu, 07 May 2015 14:59:08 GMT

Antimicrobial edible films can be used by the food industry to inactivate Salmonella in bagged organic leafy green salads. This technology provides a scientific basis for large-scale application of edible fruit- and vegetable-based antimicrobial films on foods to improve microbial food safety. Applications: Food safety Advantages: Films are edible Large scale application

Re-Usability of Plant Antimicrobial Washes Against Salmonella Newport on Organic Romaine Lettuce and Baby Spinach

JianlingL@tla.arizona.edu — Thu, 07 May 2015 14:50:34 GMT

This technology demonstrates the ability of edible washes to inactivate S. Newport on organic leafy greens, specifically showing that the effectiveness of these compounds is not diminished after multiple washings. Since the active molecules are volatile, the advantage of using edible washes in salad bags is that the films can release vapors constantly into the surrounding environment, thus maintaining constant activity over time during storage. In addition to their antimicrobial properties, these washes contain numerous beneficial nutritional and bioactive components that may also benefit hum...

Stage-Specific mRNA from Maize Endosperm for Identification of Protein-Protein Interactions

JianlingL@tla.arizona.edu — Thu, 07 May 2015 14:37:17 GMT

Stage-Specific mRNA from Maize Endosperm for Identification of Protein-Protein Interactions

Stories that Soar!

JianlingL@tla.arizona.edu — Wed, 29 Apr 2015 16:17:36 GMT

"Stories That Soar!" is a children's educational program to improve K-5 literacy through participation in theatre arts. Elementary school students write stories that are collected and transformed into live performance bringing the magic of a child's imaginations to life and allowing them to experience the power of their own stories. For more information see: www.storiesthatsoar.org

Thinking in Music

JianlingL@tla.arizona.edu — Wed, 29 Apr 2015 16:16:57 GMT

Thinking in Music is an innovative children's educational program created by Dr. Laurie Taetle in conjunction with the School of Music and the Tucson Symphony Orchestra. It is an inquiry-based approach to musical understanding with the original materials organized into three strands that provide a basis for instruction and learning.

Arizona Sexual Experiences Scale (ASEX)

JianlingL@tla.arizona.edu — Wed, 29 Apr 2015 16:15:26 GMT

The Arizona Sexual Experiences Scale (ASEX) is the pharmaceutical industry gold standard of methods designed to help identify and quantify the effects of new drugs on the sexual function of participants in clinical trials. Since 1998, the ASEX Scale has been used by pharmaceutical companies and clinics worldwide in various clinical settings. Questionnaires appropriate for male or female patients are available. “The ASEX has excellent internal consistency, scale reliability and strong test–retest reliability. ASEX appears to be useful in a range of clinical situations incl...

Business Mathematics I and II

JianlingL@tla.arizona.edu — Wed, 29 Apr 2015 16:14:46 GMT

Mathematics for Business Decisions I and II introduces a new paradigm in mathematics teaching focusing on understanding mathematics uses and applications using standard tools - Excel, Word and PowerPoint. The electronic text is licensed on a sole basis (non exclusive copyright license plus five year sole right to distribute at above cost) to the Mathematics Association of America. The MAA is publishing the text and supporting marketing and training. Several other projects are being contemplated with the MAA involving this material including the creation of a Spanish language version, adap...

Combined Vertical Axis Wind-Water Floating Turbines for River and Ocean Operations

JianlingL@tla.arizona.edu — Tue, 28 Apr 2015 14:31:53 GMT

This invention is vertical axis wind-water combined turbines for capturing energy from both the wind and the water current. Each turbine is connected axially to the energy capture device through a common floating platform. This invention has unique design aspects for the connection to each other and to the platform to maximize energy capture. Background: Electricity generation from wind turbines is an established energy sector undergoing rapid growth in the US and worldwide. The US installed wind power capacity at the end of 2007 was 16,596 MW. This represen...

Active Flow Control for Wing Performance Enhancement

JianlingL@tla.arizona.edu — Tue, 28 Apr 2015 14:26:07 GMT

This technology is an enhanced performance version of an airplane fluidic fence using active flow controls in the wing surface. The invention is applicable to wings of all shapes including helicopter rotors, propellers, wind turbines, fans and compressor blades. Background: To alleviate problems at high lift conditions, some designers have added chord-wise fences on highly swept wings. They can be seen, for example, in the MiG 15. These fences serve to interrupt the span-wise flow and alleviate the tip separation problem as well as help to redirect the flow in the fore-aft direction, which i...

Meta-Selective Alkylation of Phenolic Substrates

JianlingL@tla.arizona.edu — Tue, 28 Apr 2015 00:32:16 GMT

The technology is a method of meta-selective alkylation which requires no heating and has short reaction times relative to existing processes. The process relies on dearomatization of phenolic rings, introduction of the functional group at the meta- position, and rearomatization of the phenol. The process requires no directing group. Background: The inventors have created a detailed procedure for the process and have applied it to a range of phenolic substrates. Applications: The process can be applied in research as a way to cut costs and time requirements for necessar...

Plant Height Measurement System for Mobile Platforms

JianlingL@tla.arizona.edu — Wed, 22 Apr 2015 14:37:56 GMT

A plant height instrument which incorporates RTK (real-time kinematics) quality GPS positioning to establish an exact, unchanging soil elevation reference base while in motion. The positioning data provides the compensation necessary to accurately measure plant height while driving over uneven terrain, overcoming the instability inherent in sonar sensors used with mobile platforms due to irregular terrain. Background: Using a sensor-based approach on a mobile platform, this method of measuring plant height allows users to observe changes in plant growth over time and provides high-quality, h...

Interfacial Effects Enable Droplet Actuation, Inhibition Relief, and Early Sensing of Polymerase Chain Reaction

JianlingL@tla.arizona.edu — Thu, 16 Apr 2015 06:35:10 GMT

This invention is a device and associated methods that improve quantitative real-time polymerase chain reaction (qPCR), especially in point-of-care settings, by allowing detection of PCR amplification and quantification of initial target amount to occur at an earlier amplification cycle. Ultimately this allows for faster results, and thus faster informed medical decision-making in the point-of-care setting. This innovation is possible through the novel utilization of interfacial effects in PCR reaction droplets. Background: Quantitative real-time polymerase chain reaction (qPCR) is a m...

A Practical Online Platform for Scientific Publishing

JianlingL@tla.arizona.edu — Wed, 25 Mar 2015 12:40:38 GMT

This invention is an online submission and publishing platform for scientific articles, allowing quick categorization of articles, and using social-networking concepts to reduce the turnaround time for publication while maintaining quality in research. Background: The advantages of publishing scientific research online have been discussed for well over a decade. At the same time, many different platforms have been developed to bring these ideas to life. As the world of online publishing continues to grow, it is important that this ever expanding body of work is organized, searc...

Robotic Surgery - An Optimal Motion Planning Method for Computer-Assisted Surgical Training (optMIS)

JianlingL@tla.arizona.edu — Wed, 25 Mar 2015 12:38:00 GMT

The Infrared Retina

JianlingL@tla.arizona.edu — Fri, 06 Mar 2015 16:17:27 GMT

This invention proposes an infrared retina that exploits the continuous spectral tunability of mid-infrared quantum-dot based sensors. The detectors sense information over different spectrally overlapping bands, similar to the cones in the human eye. The resulting spectral diversity can be exploited in an array format with either fixed spatial functionality, as is done in the retina, or dynamic spatiotemporal functionality. This proposed scheme offers a new paradigm for infrared sensors that could provide infrared-color imaging capabilities akin to visible spectrum three-color imaging and pho...

A Simplified Approach to Unidirectional Solidification of Silicon

JianlingL@tla.arizona.edu — Wed, 04 Mar 2015 12:42:29 GMT

This method is a simplified approach to performing unidirectional solidification of silicon for the creation of upgraded metallurgical-grade silicon for use in photovoltaics for solar energy production. Background: Silicon is a key ingredient in the creation of photovoltaic (PV) panels for use in solar cells. Polysilicon (polycrystalline silicon) is the market leading form of silicon for PV applications. Polysilicon is traditionally produced using the Siemens process. However, the Siemens process is relatively expensive. This has created increased interest in the use of “upgra...

Producing Silicon from Silica in an Alternative Furnace to that of the Arc Furnace: A New Approach to Purifying Silicon

JianlingL@tla.arizona.edu — Wed, 04 Mar 2015 11:08:13 GMT

This technology is a new technique of producing silicon from silica in an alternative furnace to the current used arc furnace. With this new technique, the low of solar silicon will dramatically be reduced. Also, the procedure eliminates two primary sources of impurity contamination of the silicon. Background: Historically, the photovoltaics industry relied on off-spec electronic grade silicon as its primary source of the raw material. As a result of high demands of silicon, the electronics industry not in the business of producing off-specs are at risk of a silicon shortage used for...

Micro-Scale Concentrated Photovoltaic Module

JianlingL@tla.arizona.edu — Mon, 02 Mar 2015 10:44:12 GMT

This technology is a thin photovoltaic module that concentrates direct and diffuse sunlight onto each individual solar cell, which increases the efficiency. The concentrator lenses are designed to reduce tracking requirements, making these solar panels ideal for spaces requiring small footprints, such as buildings in dense urban areas. The design also includes a clever means of reducing the PV cell size under each lens so that the cells cool more efficiently. Background: Achieving concentration of sunlight onto photovoltaic cells in a small form factor has been a chall...

Radial Fast Spin-Echo (FSE) MRI Pulse Sequence

JianlingL@tla.arizona.edu — Thu, 26 Feb 2015 13:34:34 GMT

This invention is a software method that combines radial imaging (taking MRI data radially--from the center, out) with fast spin-echo (FSE) imaging to create faster, more accurate images. This technology has been demonstrated to effectively image human brains, abdominal regions, and livers. Background: Magnetic Resonance Imaging (MRI) is a very useful tool for imaging inside the human body without having to do invasive surgery. Two of the drawbacks to MRI technology currently are low image resolution and the length of time required to image. Applications...

Natural Product Modulators of Stress Response

JianlingL@tla.arizona.edu — Thu, 26 Feb 2015 13:01:55 GMT

In response to many stresses, including heat, oxidizing conditions, and exposure to toxic compounds, plant cells up-regulate an evolutionarily conserved set of helper molecules known as heat shock proteins (Hsp). Increased expression of these proteins protects the organism against stress-induced damage. The investigators have isolated a secondary metabolite produced by a desert plant-associated fungus that enhances thermotolerance in the model plant, Arabidopsis thaliana, by increasing heat shock protein levels. The metabolite acts by binding specifically to the protein Hsp90, the...

Treatment of Gonorrhea

JianlingL@tla.arizona.edu — Thu, 26 Feb 2015 10:10:22 GMT

This patented technology is a method of treatment for gonorrhea that involves the use of a commensal, non-pathogenic microorganism that antagonizes and kills the bacterium responsible for causing gonorrhea. Background: The CDC estimates that over 700,000 gonorrhea infections occur annually in the US alone. European officials have estimated that 10% of gonorrhea infections in Europe are now caused by antibiotic-resistant strains. The advent and proliferation of antibiotic-resistant gonorrhea has caused the CDC to revise its treatment guidelines, with ceftriaxone being the only ...

Piezo Electric Energy Harvesting System

JianlingL@tla.arizona.edu — Thu, 26 Feb 2015 09:50:27 GMT

This technology is a system that allows for the harvesting of the body’s mechanical energy (e.g. from the heart cycle of contraction-relaxation) and subsequent conversion into electrical energy using piezeoelectric materials. The piezoelectric materials are monolithically integrated with rectifiers and millimeter-scale batteries, allowing for concurrent power generation and storage of harvested electrical energy. The components of this system are coated in a biocompatible material with superior mechanical properties that allow for a uninhibited organ motion while avoiding delamination o...

Aerostasis in Pulmonary Surgery

JianlingL@tla.arizona.edu — Thu, 26 Feb 2015 09:30:26 GMT

This invention is a device and method for dispensing fibrin foam onto serosal tissue or lungs after surgery. It consists of three catheters that dispense fibrinogen, thrombin, and pressurized sterile air. The fibrinogen and thrombin are rapidly warmed from 0°C to 37°C, then mixed to form fibrin gel. The fibrin is then mixed with pressurized sterile air to form fibrin foam, and the mixture is sprayed onto the organ tissue or lung surface where there is damage or potential of leakage. The entire device is controlled electronically; sensors measure temperature and pre...

Mixture of Estrogens Selective for Estrogen Receptor Beta for Treatment of Neurological or Psychiatric Disorders

JianlingL@tla.arizona.edu — Tue, 17 Feb 2015 11:59:50 GMT

This technology provides a mixture of estrogens that are selective for ER-β activation, offering a novel treatment for neurological and psychological disorders. Background: Mental disorders are the number one contributor to non-communicable diseases worldwide. Mental disorders such as schizophrenia, mood disorders, substance abuse and dementia contribute more to global disease burden than cancer or cardiovascular diseases. Thus, there is a great need for novel therapeutics that can address these devastating mental disorders. Advantages: Enhances cognition Reduces anxiety ...

SHG Imaging Technique for Assessing Hybrid EO Polymer/Silicon Photonic Integrated Circuits

JianlingL@tla.arizona.edu — Mon, 09 Feb 2015 16:54:07 GMT

Scientists at the University of Arizona have developed a system for assessing the efficiency of the electro-optic (EO) polymer poling process by using multi-photon imaging in the second harmonic generation mode (SHG), permitting imaging and assessment of waveguide devices, including poled polymer devices, prior to, during, and after fabrication. This system provides depth and lateral spatial resolution up to 1 µm and can be used for multi-layer devices. Background: The emergence of data center photonics has created a demand for high speed optical modulation on a silicon p...

P-MOD: An Algorithm and System to Match Mass Spectral Data of Variant or Modified Peptide Sequences

JianlingL@tla.arizona.edu — Thu, 05 Feb 2015 13:20:25 GMT

Researchers at the University of Arizona have developed a Java coded application implementing a novel algorithm called P-Mod. This software has been developed for the screening of large data files of peptide MS-MS spectra for peptide sequences in a search list. The algorithm matches sequences to spectra with predicted mass and CID fragmentation patterns. In addition, it also has the ability to detect spectra of peptides with sequence polymorphisms or unpredicted post-translational modifications. These modified sequences are detected as spectra with a mass shift similar to the sequences they ar...

Seed Metering System and Apparatus for Precision Planting of Seed

JianlingL@tla.arizona.edu — Wed, 04 Feb 2015 13:09:50 GMT

This invention is a novel seed planter unit that provides consistent and accurate seed spacing during planting. Background: Currently available seed planters have allowed farmers to plant entire fields in a fraction of the time that was previously required. However, presently available planters have problems regarding the speed and height of seed drop, which lead to inconsistent seed spacing. Although it is well known that reducing the relative velocity between the seed and the soil surface improves seed spacing uniformity, the seed to soil relative velocity of current precision planters is...

Hybrid Microbial-Enzymatic Fuel Cell

JianlingL@tla.arizona.edu — Wed, 04 Feb 2015 12:40:54 GMT

This invention is a fuel cell that uses microbial reacts as an energy source. This process allows for continuous maintenance of the open circuit voltage of the fuel cell over the same time period without replacement of the active media. Even without media replacement the fuel cell designed runs stably making it more practical for industrial applications. Background: Enzymatic and microbial fuel cell offers a couple advantages over the standard metal based fuel cell. Enzymes are relatively easy to mass-produce. Enzymes are also specifically designed to process organic compounds ...

High Efficient Continuous Wave and Mode-Locked Lasers Powered by Solar Energy

JianlingL@tla.arizona.edu — Wed, 28 Jan 2015 11:43:48 GMT

Faculty at the University of Arizona have developed a compact, efficient solar-powered laser that uses triple junction photovoltaic cells to power semiconductor and mode-locked lasers. Existing solar-pumped lasers use an arc-metal-halide lamp pump that requires bulky concentrating optics and is power inefficient. By using a triple junction photovoltaic cell, the laser can produce a sunlight to laser light efficiency of over 10 percent without cooling and concentration optics. This system is more efficient, lower cost and more compact than direct solar pumped lasers. The technology can greatly...

Substrate and Solvent Mediated Synthesis of Fullerene Self-Assemblies

JianlingL@tla.arizona.edu — Tue, 27 Jan 2015 10:20:38 GMT

Fullerene can be engineered into many different shapes and sizes. The self-assembled fullerene fabrication can lead to large structural variations depending on the methodology used in the procedure. Since Fullerene was discovered in 1985, the structural variations on fullerenes have expanded from just simple individual clusters. This technology determines a method to synthesize self-assemblies of fullerene whose structure is mediated by the solvent and substrate used in procedure. The solvent and substrate mediated synthesis can craft fullerene structures that are flower-like s...

Fullerene-Graphene Based High Efficiency Supercapacitors

JianlingL@tla.arizona.edu — Tue, 27 Jan 2015 10:14:44 GMT

This technology provides for enhancing capacitor power density, capacitive retention, and stability by using self growing nano particles on the electrodes of capacitors. Specifically, double-layer capacitance achieve electrostatic storage by separation of charge in a Helmholtz double layer at the interface between the surface of a conductive electrode and electrolyte. The invention couples graphene flakes and porous graphite with self-assembly fullerene to provide the ability to attain high areal and specific electric double layer capacitance. Applications: Enhances battery or c...

Geopolymer Fly Ash Brick With Phase Change Material added for Energy Savings in Buildings

JianlingL@tla.arizona.edu — Tue, 27 Jan 2015 09:54:04 GMT

This invention is a method of reducing energy consumption related to space cooling and heating in a building by incorporating phase change material in geopolymer concrete wall. The results are very promising and indicate that the geopolymer concrete with incorporated PCM shows only little decrease of the compressive strength and is very effective in controlling heat flow. Background: Extensive research has been conducted on different methods for enhancing the energy efficiency related to space heating and cooling in buildings. Of these different methods, utilization of phase change ...

Combined Algal Harvester and Mixer

JianlingL@tla.arizona.edu — Tue, 27 Jan 2015 09:31:49 GMT

This invention combines an eloctrocoagulatlon harvesting system and a traditional paddlewheel to harvest algae while mixing a traditional reactor allowing the harvesting to take place in the reactor system. In addition, this process is energy efficient which is the largest obstacle preventing sustainable bio fuels from hitting the market. Background: Currently water will be mixed using a paddlewheel and then at a later point the water will be pumped out of the system where the algae is extracted from the water. Extraction methods include filtration, centrifugation, or even electrocoagulati...

Integrated Reformer, Reactor, and Control System for Efficient H2 Production from Hydrocarbon Fuels

JianlingL@tla.arizona.edu — Tue, 27 Jan 2015 09:03:53 GMT

This invention is a control system that allows the precise combining of a hydrocarbon fuel, steam and Ai/O2 l in an integrated auto-thermal reformer and water-shifting reactor unit. The device can achieve thermal management to have favorable high and low temperature for both auto thermal reformers and water shifting reactors. Applications: Hydrogen fuel cells Processing / refining Chemical synthesis Advantages Achieves thermal management to have favorable high and low temperatures High hydrogen conversion rate from hydrocarbon fuels Allows integration...

Fiber-Based Bidirectional Optical Parametric Oscillator for Precision Sensing

JianlingL@tla.arizona.edu — Sat, 24 Jan 2015 15:41:21 GMT

Researchers at the University of Arizona have developed an all-fiber, synchronously pumped, bidirectional optical parametric oscillator (OPO) for precision sensing applications. The all-fiber design removes the need for free-space alignment and adjustment. The design overcomes the limitations of existing laser gyros by increasing the sensing area for better measurement sensitivity, minimizing the lock-in effect, and reducing the cost, complexity, and size. The system and techniques are applicable to a variety of different fiber optic ring laser sensors. Background: He-Ne r...

Control of Microbial Growth via Novel Regulatory Events in the TORC Pathway

JianlingL@tla.arizona.edu — Tue, 20 Jan 2015 15:13:46 GMT

This invention relates to systems, methods, and compositions for treating or preventing diseases associated with eukaryotic organisms, more particularly to methods and compositions for directly or indirectly triggering and/or permitting, or inhibiting Raptor/Kog1 aggregation in specific eukaryotes. This technology is a proposed class of novel drugs for the treatment of diseases caused by eukaryotic organisms, and a method of screening for such drugs. These antifungal and antiparasitic drugs will rely on a newly discovered cell signaling pathway that is present in many eukaryotes that cau...

Control of Microbe Growth via Novel Regulatory Events in the TORC Pathway

JianlingL@tla.arizona.edu — Mon, 19 Jan 2015 18:18:18 GMT

This technology is a proposed class of novel drugs for the treatment of diseases caused by eukaryotic organisms, and a method of screening for such drugs. These antifungal and antiparasitic drugs will rely on a newly discovered cell signaling pathway that is present in many eukaryotes that cause infection in humans, but is not present in human cells. It is expected that these drugs could be used alone or in conjunction with other drugs to fight such infections. Background: Human diseases caused by eukaryotes include fungal infections and parasitic diseases. Parasitic diseases include not onl...

Core Shell Nanofibers for Tissue Engineering of Scaffolds for Stem Cells

JianlingL@tla.arizona.edu — Wed, 14 Jan 2015 15:37:40 GMT

This technology is a method of coaxial electrospinning used to fabricate PVA and gelatin into defect-free composite nanofibers with PVA in the core and gelatin in the shell. These nanofibers can be used as composite scaffolds for a variety of applications including tissue engineering and scaffolds for stem cells. Background: Electrospinning as a versatile fiber-formation technique has evolved from generating uniform, single-component fibers to creating complex, multiple-component composite fibers with spatially and/or temporally controlled properties. The high specific surface areas, p...

Expression of Nicotinamide Phosphoribosyltransferase Mediated Genes Predicts Recurrence-free Survival in Lung and Breast Cancers

JianlingL@tla.arizona.edu — Wed, 14 Jan 2015 15:36:53 GMT

The technology is a prognostic cancer gene assay for lung and breast cancer that utilizes a new biomarker. The technology fills a current need for better prognosis tools for triple negative breast cancer tumors and provides a new discovery in gene expression profiling. Background: This biomarker, NAMPT (nicotinamide phosphoribosyltransferase), is a novel oncogene responsible for the biosynthesis of nicotinamide adenine dinucleotide (NAD). NAD is an essential molecule involved in metabolism. There are an estimated 184,450 new cases of breast cancer and 215,020 new cases of lung cancer...

Flowable Electronics in Improving Surgical Devices

JianlingL@tla.arizona.edu — Wed, 14 Jan 2015 15:19:55 GMT

This invention provides minimally invasive technologies to access deep tissue structures through an electronic device that can be poured, splashed, drizzled, misted, or sprayed on a surface. This technology is poised to take advantage of a growing opportunity in the surgical medical device field. Background: Electronics and digital devices have become mainstream, but a basic limitation still exists. Electronics are created from conductors and generally these materials are stiff or rigid (copper, aluminum, etc). On the other hand, biologic domains are flexible and complaint and there...

HyperShear in a Channel: A Microfluidic Facsimile of Ventricular Assist Devices to Reduce Thrombotic Risk and Enhance Patient Safety

JianlingL@tla.arizona.edu — Wed, 31 Dec 2014 05:56:52 GMT

This technology utilizes device thrombogenicity emulation--a method which mimics the shear stresses that would be exhibited within the patient in order to assess proper anti-thrombolytic therapies. Shear stresses are observed in a microfluidic facsimile of a ventricular assist device (VAD), which can quickly be translated to assess the personal risk of thrombosis. This allows for point of care testing on a patient-by-patient basis with optimal therapy dosages. Background: There are 670,000 new cases of heart failure every year with roughly 160,000 patients being eligible for a ...

Modulation of Platelet Function

JianlingL@tla.arizona.edu — Wed, 31 Dec 2014 05:50:26 GMT

This novel invention provides a method to limit the effects of shear stress from MCS devices on the platelet cells of patients with congestive heart failure. The invention has been shown to reduce platelet activation and aggregation in vivo by mitigating the effects of shear stress by increasing platelet membrane fluidity. Background: Cardiovascular disease (CVD) is the leading cause of death worldwide, responsible for over 17 million deaths per year. At the beginning of the 20th century, cardiovascular disease was responsible for less than 10% of all deaths worldwide, but by the start of th...

Adjustable Hybrid Diffractive/Refractive Achromatic Lens

JianlingL@tla.arizona.edu — Wed, 17 Dec 2014 14:06:44 GMT

Researchers at the University of Arizona have designed an achromatic variable focus lens that can correct for Seidel Aberrations in addition to chromatic dispersion. The technology uses fluid pressure control to alter the curvature of clear membranes containing fluid in correlation with the wavelength and the desired focal length. Software enables the user to select two different fluids based on the desired Abbe number and index of refraction. The user then selects the desired focal length and the lens automatically changes the two radii of curvature to adjust the focal length. In t...

Optical Device for In-Line and Real-Time Monitoring of Microalgae

JianlingL@tla.arizona.edu — Fri, 05 Dec 2014 12:04:04 GMT

This invention is an optical-based sensor system which uses wavelengths and laser technology to monitor microalgae in real-time. The emitted wavelengths range from 650nm to 850nm for the purpose of determining biomass concentration. The device is able to measure the following: cell concentration, size, reflectivity of particles, intensity of color, and turbidity of the solution. Background: Current methods of measuring biological variables such as cell mass concentration, cell size, cell morphology, population composition, pigments, and liquid content are currently either prohibitively ...

Tracking System for Agriculturally Produced Crops

JianlingL@tla.arizona.edu — Fri, 05 Dec 2014 12:03:52 GMT

Researchers at The University of Arizona College of Agriculture and Life Sciences are extending the Tracing System for Agriculturally Produced Crops by adding the ability to georeference (at the carton-level) cut and packed iceberg lettuce to a precise field location at the Yuma County Cooperative Extension in Yuma, AZ. The system uses RFID and integrated GPS technologies to provide a field georeference for the carton containing the freshly cut and packed produce. Background: U.S. food producers have developed sophisticated systems to track the flow of food along the supply chain, for example...

HEK Cell Line Expressing Human EP4 Prostanoid Receptors

JianlingL@tla.arizona.edu — Fri, 05 Dec 2014 12:03:50 GMT

Nucleotides 360-1890 from the human EP4 prostanoid receptor were PCR amplified from the small intestine, and digested with SspI and ScaI. The product was cloned into the plasmid ECoRV. This plasmid was digested with HindIII and XhoI, and the product was cloned into pCEP4, and transfected into 293-EBNA cells. Transformed lines were selected with hygromycin. The resulting protein was selected by PGE2 stimulation of cAMP formation. It was further characterized by immunofluorescence microscopy with a human EP2 receptor antibody and radioligand binding of [3H] prostaglandin E2. Background:...

Cardiac Arrhythmia Visualization in a Virtual Heart Model for Electrophysiology Education

JianlingL@tla.arizona.edu — Tue, 02 Dec 2014 08:22:07 GMT

This technology is a software method of modeling cardiac arrhythmia for the purpose of electrophysiology education. Advantages: Assisting students to understand physiology Receiving full range of the model Updated health information has been supported significantly via mobile applications and mp3 players for e-learning Allowing mobile use Applications: Education of students, patients and healthcare professionals, with regards to health issues The paid mHealth app can be used for this application

Snapshot Imaging Fourier Transform Spectrometer with Achromatic Wollaston Prisms

JianlingL@tla.arizona.edu — Sun, 30 Nov 2014 12:04:48 GMT

Researchers at The University of Arizona have developed a novel device that answers challenges of increased robustness and faster acquisition time. This new device has no moving mechanical parts, mounts directly onto the focal plane imaging array, and acquires both the spectral and spatial information at once. Thus, this new device is significantly more robust than its predecessors in the field, and it offers a true snapshot capability. Its form factor is also significantly reduced with respect to its predecessors. Furthermore, due the device’s passive design, it does not require any po...

Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers

JianlingL@tla.arizona.edu — Sun, 30 Nov 2014 12:02:02 GMT

Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic units that are more stable, with higher efficiencies and shorter manufacturing times than lasers created by conventional manufacturing techniques. These FBGs show high thermal stability making them suitable for fiber lasers operating at high av...

Dark Field Solid Immersion Objective for a Microscope

JianlingL@tla.arizona.edu — Sun, 23 Nov 2014 09:47:43 GMT

Researchers at the University of Arizona have designed a novel dark field illumination objective lens with a high numerical aperture. The oblique illumination angles of this novel objective enhance contrast and reduce scattered light to help view objects whose refractive index is close to that of the surrounding medium. Applications: Biomedical imaging Advantages: High illumination uniformity High numerical aperture Status: Concept tested through computer modeling; Provisional Patent Application filed.

An Imaging Polarimetric Camera

JianlingL@tla.arizona.edu — Thu, 20 Nov 2014 07:56:02 GMT

High Power Mid-Infrared Supercontinuum Fiber Lasers at 2-5 µm

JianlingL@tla.arizona.edu — Thu, 20 Nov 2014 07:23:10 GMT

Researchers at the University of Arizona have developed a supercontinuum laser that has high power output over the 2-5 micron wavelength range. Background: There are various methods for generating a mid-infrared laser source. The problem commonly faced is that it is difficult to emit on a supercontinuum in the IR region. Most competing lasers emit no higher than 2.4 micrometers with a relatively low power. Advantages: Higher power than competitors Supercontinuum Applications: Biomedical imaging Spectrophotometry Missile countermeasures Status: issue...

Software for SCOTS (Software Configurable Optical Test System)

JianlingL@tla.arizona.edu — Thu, 20 Nov 2014 07:13:48 GMT

Optical Membrane Formation System Method

JianlingL@tla.arizona.edu — Tue, 28 Oct 2014 10:51:35 GMT

This invention relates to the field of membrane formation and in particular relates to the formation of optical membranes on optical surfaces such as prisms and the like. A spectroscopy system has at least one light source operable to generate a source beam and a prism having a rear surface. A support block is disposed on the rear surface of the prism. The support block is formed with at least one sample well having a center and defines a substantially vertical rear cell surface having a center. The source beam is aimed at the sample well. A syringe filled with a membrane solution and having ...

Beam Shifting Surface Plasmon Resonance System and Method

JianlingL@tla.arizona.edu — Tue, 28 Oct 2014 10:48:01 GMT

The invention relates to a surface plasmon resonance (SPR) system method. The system has at least one light source operable to generate a source beam, a prism having a rear surface at least partially coated with metallic coating and optionally a dielectric layer. At least one layer under test is positioned on the rear surface of the prism. The source beam is directed at the layer under test thereby defining an angle between the source beam and the rear surface of the prism. A detector is operable to detect light that is reflected or scattered by the layer under test. The source beam is direct...

Holographic Lens / Mirror Aperture (HL/MA) Design for Hybrid Thermal Solar Systems

JianlingL@tla.arizona.edu — Sun, 12 Oct 2014 11:47:57 GMT

Researchers at the University of Arizona have designed a hybrid solar collection and distribution system to optimize the use of the solar collector footprint as well as the solar spectrum. The system splits the spectrum into two components to distribute the peak wavelengths for algae growth, PV, and thermal uses. Algae responds best to photosynthesis wavelengths (400-700 nm) whereas photovoltaic cells and thermal collectors respond well to different and broader spectral ranges. In the UArizona design, one wavelength band is focused by a holographic lens through a mirror aperture ont...

Simplified Process for Fabricating Interdigitated Energy Storage Devices

JianlingL@tla.arizona.edu — Thu, 09 Oct 2014 08:36:21 GMT

Researchers at The University of Arizona and the University of California, Irvine, have developed a simplified process to prepare interdigitated energy storage devices (IESD). These are compact, 3-dimensional structures with superior energy densities: projected values are approximately 10,000 times larger than a conventional parallel plate capacitor. IESD's contain high-surface area nano-rods of conducting material, allowing for more energy storage per unit volume than a parallel plate capacitor could ever hope to achieve. IESD's can be fabricated from commercially available nano...

Gamma Ray Imaging System for Rapid and Precise Detection of Radioactive Materials from a Distance

JianlingL@tla.arizona.edu — Thu, 09 Oct 2014 08:01:26 GMT

This invention is a gamma detection system that determines the position and energy of gamma sources within its field of view without using a pixelated full-energy detector. In addition, the present gamma ray imaging systems utilize coincidence measurements, which reduces the background level compared to systems that do not use coincidence methods to filter detected events. Advantages: Greater detection efficiency than a pixelated full-energy detector Provides for a less expensive system than conventional gamma ray imaging systems, such as a conventional Compton camera or a conven...

An Electrokinetic Matrix Management and Polymerase Chain Reaction Device

JianlingL@tla.arizona.edu — Thu, 09 Oct 2014 07:56:43 GMT

The following hybrid electrokinetic module allows for sample preparation, PCR, and sensing all on one integrated platform. There are three modules on the platform: the first module isolates targets (cells, bacteria) from high conductivity samples (urine, blood). The second module amplifies nucleic acids through PCR and the third module senses the target. Applications: There are many potential diagnostic applications for this technology, Hybrid electrokinetic module allows for sample preparation, PCR and sensing all on an integrated platform that: allows for large scale volume...

A Method for Improving Spectrum Sensing/Efficiency in Cognitive Wireless Systems

JianlingL@tla.arizona.edu — Thu, 09 Oct 2014 07:42:48 GMT

To improve the sensing efficiency and/or the throughput for the SUs, this technology develops a new adaptation method that exploits selfinterference suppression (SIS) capabilities in an SU device. Using this adaptation method, an SU can switch between a transmission-sensing (TS) mode and transmission-reception (TR) mode. Background: In a DSA environment, wireless devices may be operated by primary (non-adaptive) and secondary (adaptive/cognitive) users. Secondary users (SUs) are allowed to access the spectrum opportunistically on a non-licensed basis, provided that they do not harm ...

Metal Free Scalable Synthesis of Fluorinated Indole and Benzofuran Structures

JianlingL@tla.arizona.edu — Mon, 06 Oct 2014 23:20:59 GMT

This technology is a novel one step method to generate fluorinated aryl groups for use in various other reactions. Background: There are few alternative existing methods to treat arrhythmia. Originally, there were a slew of powerful anti arrhythmic drugs on the market which had the potential to treat the cardiovascular condition. However, the majority of these drugs were revealed to actually increase mortality rates rather than decrease them. This left only two major compounds in the field, dronedarone and amiodarone. Another way to treat arrhythmia is the pacemaker. While a pa...

Novel Inhibitors of GAB1

JianlingL@tla.arizona.edu — Mon, 06 Oct 2014 23:18:25 GMT

The compounds discovered in this patented technology could be used as a breast cancer therapeutic drug. There are a few call signaling pathways that are heavily involved in the pathogenesis of cancer. Two of these pathways are the RAS pathway and the PI3K pathway, and both of these pathways are deregulated in the formation of human cancer. This deregulation leads to the over-production of GAB1. It has been shown that inhibiting upstream components of pathways complicit in tumorigenesis can reduce the rate of cancer. This is demonstrated in inhibitions of PI3K in the PI3K pathwa...

Assay Device with Tunable Array of Unique Steady-State Microfluidic Gradients

JianlingL@tla.arizona.edu — Thu, 18 Sep 2014 08:10:01 GMT

This invention is an assay device based on the common T-shaped microfluidic geometry to produce an array of unique gradients. The Assay Device with Tunable Array of Unique Steady-State Microfluidic Gradients contains two reservoir channels, an intersection point, a source and sink channel, an array of microchannels and a shared exit port. Within the device there are two gradients developed: one that forms along the length of the source channel and another within the perpendicular set of microchannels. The magnitude of the gradient intensity relies on the ratio of the two flow inlets without t...

Repairable Data Blocks and Method of Data Block Reconstruction for Large Scale Cloud Storage Systems

JianlingL@tla.arizona.edu — Wed, 10 Sep 2014 18:38:50 GMT

This invention is a new approach to reinforcing the storage system by storing the data with specifically placed redundancies that reduce the chance that all copies of the same data will be lost simultaneously. The invention also allows for possible reconstruction of lost data using remaining data. Background: Online cloud computing systems utilizing distributed data storage actually divide the information into “blocks” which are stored amongst several different nodes. If and when some of these nodes fail, the blocks they are storing can be at least temporarily lost, caus...

Method and Apparatus for Deep Ultraviolet Microscopy

JianlingL@tla.arizona.edu — Tue, 02 Sep 2014 14:02:09 GMT

Researchers at the University of Arizona and formerly at UC San Diego have developed a nanometer resolution optical microscope. It uses an intense, monochromatic radiation of the atomic Hydrogen line (H Lyman-alpha light source) for the improved imaging resolution. The light source emits at a wavelength in which there is a local minimum of the air absorption spectrum, allowing effective transmission in air and obviating the need for the target to be in a high vacuum. The light source can increase optical imaging resolution by fourfold, which making optical microscopy more useful f...

"Rock Softening" Method and Apparatus for Efficient Drilling

JianlingL@tla.arizona.edu — Thu, 28 Aug 2014 08:23:52 GMT

This invention is a method for improved material weakening including rocks, concrete, and other man-made materials. The method established uses an imbalance between the rate of energy input and the rate of energy dissipation in the material resulting in a more significantly more efficient material breakage process. This imbalance is established by reducing the rate of energy dissipation, employing a chemical and/or electric field potential induced in the material. The chemical approach creates a layer of zero zeta potential at the contact between the rock and the tool. The electric field...

Video Image Based Bed Load Analyzer

JianlingL@tla.arizona.edu — Thu, 28 Aug 2014 08:06:35 GMT

This instrument enables the automation and accurate measurement of bed load transport rate using modern innovations in digital images, processing, and wireless technologies. Its novelty allows for analysis of sediment transport without collecting actual samples. Background: Current methodology measures bed load sediment by grabbing samples of river bottoms physically, either by mechanical scoops or sediment traps. There is no current feasible way (inexpensive, accurate, automatic etc.) way to measure bed load especially in large non-wadable rivers. Current methods are not ideal especially ...

JianlingL@tla.arizona.edu — Wed, 27 Aug 2014 10:00:24 GMT

NSF funded MAPPS, a project to develop activities and materials to engage the parents of school-age children in the mathematics of the schools. One set of activities developed consisted of mini-courses; Geometry for Parents is one of these. Each mini-course consists of 8 two-hour sessions for parents participants. The book is a guide for individual(s) facilitating the mini-course, and includes handouts for the parents. These guides are unique and there is no measurement of competition.

Interactive Self-Study iBook for Spanish-English Interpreters

JianlingL@tla.arizona.edu — Wed, 27 Aug 2014 09:59:42 GMT

This is an Interactive Self-Study iBook for Spanish-English Interpreters designed to help improve the proficiency skills of Spanish-English interpreters, specifically those working in a judicial context. It likewise helps Spanish-English interpreters that are preparing for the Federal Court Interpreter Certification Examination (FCICE). This self-study iBook contains descriptions of the examination process, oral test procedures, a practice test, and audio recordings of actual interpreters taking the same sample test. It can be downloaded onto a device and doesn’t require an internet con...

National Center for Interpretation Navajo Legal Training and Testing Materials: 1993-2013

JianlingL@tla.arizona.edu — Wed, 27 Aug 2014 09:49:57 GMT

This training program provides the necessary examination material for proper certification of Navajo court interpreters in consecutive, sight, and simultaneous interpretation. The materials included allow for proper interpretation in legal settings such as standards, ethics, protocol, medical terminology, and more. The Navajo training materials encompass presentations, scripts, glossaries, and manuals to be used in connection with live, skills-based practice using a wide variety of realistic scenarios. Testing materials encompass written and oral exams, and the Navajo court interpreter oral c...

A Vector System for Direct Cloning of Eukaryotic Gene Constructs

JianlingL@tla.arizona.edu — Tue, 26 Aug 2014 20:16:40 GMT

Yeast-Agrobacterium-Bacteria (YAB) is a combination of two technologies: yeast recombination capabilities and Agrobacterium tumefaciens-mediated transformation (ATMT). Generation of ATMT constructs usually requires PCR-amplification of DNA fragments and multiple cloning steps into binary Agrobacterium vectors. YAB is a plasmid vector that can be used to combine in one single step several kinds of DNA fragments using the yeast recombination machinery instead of restriction and ligation enzymes, producing a construct that can afterwards be used to introduce the combined DNA fragments into fungi...

Enhancing the Sugar, Starch, and Cellulose Content in Plants

JianlingL@tla.arizona.edu — Tue, 26 Aug 2014 20:15:26 GMT

This technology comprises an approach to “fool” the whole plant or targeted tissues of the plant to perceive low nitrogen status. The goal is to induce the plant to remodel its growth into increasing the ratio of carbon to nitrogen via reprogrammed metabolism. By genetically manipulating the plant’s perception of nitrogen status, and therefore apparent nitrogen availability, it is feasible to induce the plant to redirect a large fraction of carbon flux from protein to carbohydrate polymers. Background: Asparagine (Asn) is one of the primary nitrogen transport vehicl...

Exploiting Novel Pseudomonas Syringae Bacteriocins as Antibacterials

JianlingL@tla.arizona.edu — Tue, 26 Aug 2014 20:09:42 GMT

This invention relates to a method of controlling phytopathogens through bacteriocin-mediated inhibition of bacterial plant pathogens. This method reduces the number of bacteria found on the surface of a plant. Specifically, this invention relates in one embodiment to Pseudomonas syringae (P. syringae) strains tailored to controlling phytopathogens. Background: Pseudomonas syringae (P. syringae) is a phenotypically and ecologically diverse plant pathogen able to infect an array of host plants. Species of P. syringae is divided (largely based on phenotype) into 50 pathovars that cause a var...

Identification of Endohyphal Bacterial Symbionts as Major Determinants of Cellulase and Ligninase Activity in Fungi

JianlingL@tla.arizona.edu — Tue, 26 Aug 2014 20:01:27 GMT

This technology discloses a method whereby EHB were shown to markedly influence cellulose and ligninase activity in fungi. It can be applied in industries relevant to biofuel development from plant material, remediation, and other industrial processes. Background: Plant-associated fungi play important ecological roles as pathogens, mycorrhizae, endophytes, and saprotrophs. As endophytes, Fungi colonize healthy, living plant tissues, providing protection from pathogens, herbivores, and other environmental stressors such as drought. As saprotrophs, Fungi are the primary decomposers of senesce...

Automated Robotic Heat Exchanger Tube Cleaning and Inspection Machine

JianlingL@tla.arizona.edu — Thu, 21 Aug 2014 08:16:46 GMT

This invention consists of an automated machine to clean individual tubes on chiller condenser barrels with minimal operator input. The invention works by mounting a typical manual tube punching device onto a mobile frame, which utilizes imaging technology to determine the location and accessibility of a tube. It then automatically maneuvers the punching device in place, cleans the tube, and repeats this process with the next tube. The invention also implements sensors to determine if either the punching device or tube is damaged and needs replacement. Background Chillers are ma...

UAbacus App

JianlingL@tla.arizona.edu — Wed, 20 Aug 2014 09:04:56 GMT

With the UAbacus you can add and subtract numbers using the "logic method" for abacus computation. Those learning abacus computation can practice their computation skills getting help with a step if they become stuck and having the correct answer verified. Users who do not know how to compute using a Cranmer abacus using the logic method can support individuals who are abacus users by following the steps necessary to solve the problem as the individual works the problem on a Cranmer abacus. Available on iTunes

Arizona's Economy Application for i-Phone, i-Pad, and Android

JianlingL@tla.arizona.edu — Tue, 19 Aug 2014 15:04:13 GMT

This Interactive phone and tablet application extends the reach, accessibility, and timeliness of the socio-economic indicator data the University of Arizona Economic and Business Research Center (EBR) offers to the citizens of Arizona and the world. This phone and tablet application allows users to access real-time data pertaining to Arizona, Its counties and metro areas by data topic and by geography. This app is unique in that it offers detailed up-to-date time-series data on Arizona and its communities In an interactive phone/tablet app format. This app is also unique in that it allows us...

Dr. Sakles' Airway CQI Form

JianlingL@tla.arizona.edu — Thu, 31 Jul 2014 11:29:07 GMT

The Airway CQI form is a data collection form used to track intubation practices performed in the Emergency Department at the University of Arizona Medical Center. The purpose of the form is to collect pertinent data on emergency intubation activities and use the data as a CQI tool to improve the care delivered to patients. Background: When dealing with medical practices, patient care quality is important and it always needs to be evaluated and re-evaluated. Video laryngoscopes such as the C-MAC and GlideScope are becoming more common, but information on their use ...

Polymerization of Lipid Assemblies in Aqueous Solution at Neutral pH

JianlingL@tla.arizona.edu — Tue, 22 Jul 2014 10:28:43 GMT

This invention is a novel method to induce radical polymerization in lipids in a neutral pH environment, preserving protein bioactivity. It utilizes a different set of reagents than a typical radical polymerization. This invention provides compounds comprising a triazenylidene moiety and methods for producing and using such compounds. Background: Normally, polymerization of lipids involves the production of acidic side products. Acidic conditions usually compromise protein bioactivity, rendering them useless when combined with the polymer. Advantages: Neutral pH is ...

Stabilized Black Lipid Membranes Prepared via Polymer Scaffolding

JianlingL@tla.arizona.edu — Tue, 22 Jul 2014 10:27:39 GMT

This invention presents a new approach for stabilizing black lipid membranes (BLMs) relying on inexpensive commercially available materials. Here, a method is employed that chemically modifies the lipid membrane to dramatically improve BLM stability. Background: Black lipid membranes (BLMs), are synthetic membranes used to measure ion channel activity. Suspended lipid membranes, BLMs, provide a key technological platform for the incorporation of ion channels and other biological nanopores. These nanopore membranes play a key role in DNA sequencing, biochemical sensing and have poten...

Targeting the PH/DH Domain of Tiam1 for the Treatment and/or Prevention of Bone Metastases

JianlingL@tla.arizona.edu — Wed, 28 May 2014 15:42:29 GMT

Tiam1 is a highly conserved exchange factor that is over-expressed in many cancers, including prostate cancer (CRPCA). Increase in Tiam1 expression is associated with increased metastases and correlates with poor PCA patient survival prognosis. This patented technology has identified a novel compound which exhibits the ability to reduce prostate cancer bone metastasis by binding to the cPH domain of Tiam1 and inhibiting its cellular functions. Background: Prostate Cancer (PCA) is a heterogeneous disease and the 5-year survival rate for men whose cancer has metastasized at the time of ...

A Broadband Apparatus for Generating and Sampling Polarization States

JianlingL@tla.arizona.edu — Thu, 15 May 2014 13:23:07 GMT

Researchers at the University of Arizona have developed thin-film polarization devices that generate and/or sample light-polarization states over a broad band (wide wavelength range) and over wide angles. The polarizers incorporate and exploit multiple polarization layer groups and can be integrated into a microarray and incorporated into a light source or a polarization camera. Background Polarization is one of the primary characteristics of light. Current polarizers can measure or create both linear and circularly polarized light, but they are limited to operating over a narrow ran...

Solution-Processable Side-Strapped Phthalocyanines

JianlingL@tla.arizona.edu — Sun, 11 May 2014 01:47:15 GMT

This invention describes a novel side-strapped derivative of pthalocyanine for use in photovoltaic cells to generate a current in a more efficient manner. Background: Within the context of photovoltaic solar power, there are other compounds based on the pthalocyanine structure that are in use currently. These other compounds have an energy conversion of 11% at their highest. The variations of the core molecule come chiefly from the different metals places in the complex onto it, including: copper, aluminum, and palladium. These alternate compounds still have to overcome a series o...

Method for Guiding Cell Spreading in Automated Cytogenetics Assays

JianlingL@tla.arizona.edu — Tue, 15 Apr 2014 13:45:14 GMT

This invention presents a method and system for overcoming some of the intrinsic limitations that automated cytogenetic assays have by establishing a model whose parameters can be analyzed and controlled suitable for an automated system. The ability of characterizing fluid behavior at a scale comparable to the size of cells by interference fringes is expected to facilitate further understanding of the metaphase spreading process at micro- and nano- scale. Background: Although the image analysis of chromosomes and other cellular components can be automated for high throughput cytogene...

Molecular Imaging of Cancer Cells in Vivo

JianlingL@tla.arizona.edu — Wed, 19 Mar 2014 09:55:57 GMT

This technology is a non-invasive method of detecting cancer using in vivo probes that target and bind to receptor cites on or around the cancerous growth. Applications: Cancer detection - identify and confirm possible tumors Optical imaging probe Advantages: As an optical imaging probe, there is a high sensitivity for ligand detection and binding. This allows for a high detection success rate as well as the visualization of subtle anomalies. The probe is not radioactive, making it safer than the PET scan alternative probes As a fluorescent probe, it is more versatile than th...

Redox-Directed Chelators Targeting Intracellular Metal Ions

JianlingL@tla.arizona.edu — Wed, 19 Mar 2014 09:55:56 GMT

Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, taking advantage of the reducing environment found in the cytoplasm of cancer cells in order to apply redox-directed chelators. Background Basic and clinical research has improved significantly the prognosis and number of treatment options for cancer patients in the past...

Levels of Emotional Awareness Scale - Electronic Version (eLEAS)

JianlingL@tla.arizona.edu — Wed, 19 Mar 2014 09:55:55 GMT

The Levels of Emotional Awareness Scale - electronic version (eLEAS) provides easy online administration and scoring of the LEAS. Whether working with an individual client, a small clinical population, or a research sample of hundreds, test versions are readily selected and scores are available at the click of a button. A user-friendly interface makes it easy to track test completion and manage data output. eLEAS - Levels of Emotional Awareness Scale web based software application. The LEAS has been used extensively, both by Dr. Lane and other researchers, a children’s version has ...

All-Fiber Multicore Fiber Laser Devices

JianlingL@tla.arizona.edu — Fri, 31 Jan 2014 10:09:23 GMT

Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends of a piece of active multi-core fiber, with dielectric mirrors coated at the two passive fiber facets to realize the in-phase super-mode selection. Background: The need for high-power fiber laser products already exists in the industrial...

A Streamlined Process to Generate Nitroaromatic Compounds

JianlingL@tla.arizona.edu — Wed, 22 Jan 2014 13:14:24 GMT

This invention is a new, one-step, streamlined synthetic process used in the nitration of aromatic compounds. In practice, this novel synthetic method has been used to prepare 2,4-dinitroanisole, a high energy compound with superior resistance to heat and shock. This compound can have uses in the mining and construction industries (roads, bridges, etc.). Other compounds that can be formed using the invented reaction include: nitrobenzene, which can be used as an ingredient in analgesics; dinitroltoluene, which is a common plasticizer; dinitronaphthalene, which can be used ...

The Fluorescence Emission Spectrometer (FLORES)

JianlingL@tla.arizona.edu — Tue, 07 Jan 2014 12:38:43 GMT

This invention discloses a high resolution spectrometer (resolving power >20,000) that can resolve individual Fraunhofer absorption lines in the solar spectrum. When in Earth orbit the image of the surface on the entrance slit of the spectrometer is swept along perpendicular to the spacecraft motion such that the ground resolution along the slit equals the forward motion of the slit in a single integration time. The solar absorption lines are so deep that the spectrometer with its high signal to noise ratio can sense the emitted fluorescence caused by photons released during photosynthesis...

Optimization of Electrical Stimulation of Neurons and Other Biological Matter/Tissue for Neural/Brain/Intramuscular/Vision Implants.

JianlingL@tla.arizona.edu — Wed, 13 Nov 2013 14:52:40 GMT

(UA13-019 and UA13-025) This invention introduces a number of disruptive improvements for neural/biological tissue stimulation. These include: (1) a time profile for the electric stimulation field that leads predominantly to transverse stimulation of nerve cells; (2) auxiliary electric fields for field shaping with a time profile chosen such that these currents have a small probability of causing undesired cross-talk stimulation of adjacent nerve cells; and (3) a local area scanning procedure, which results in highly localized neural stimulation, e.g., pixel density for highly spatially resolv...

Optimization of Electrical Stimulation of Neurons and Other Biological Matter/Tissue for Neural/Brain/Intramuscular/Vision Implants

JianlingL@tla.arizona.edu — Wed, 13 Nov 2013 14:52:39 GMT

Formulaic Imaging for Tissue Diagnosis

JianlingL@tla.arizona.edu — Wed, 13 Nov 2013 14:52:38 GMT

This patented system (U.S. Patent 9,952,157) uses a combination of green and blue fluorescence with reflectance, aimed at simple but effective contrast improvements through division, multiplication, subtraction and additions of individual images. To the best of our knowledge no other formulaic images system based on three or more components uses near-UV or mid-UV excitation. Observation is conducted at one or multiple wavelength bands ranging from 300-800 nm. Signal is related to emission of native fluorophores such as tryptophan, NADH, collagen, elastin and FAD and light that is reflec...

Antimicrobial Efficacy of Treatments Based on Plant Compounds

JianlingL@tla.arizona.edu — Thu, 17 Oct 2013 08:52:28 GMT

Researchers at the University of Arizona have demonstrated synergistic effects of silver and natural plant antimicrobials resulting in an effective, inexpensive, safe treatment with a wide variety of potential applications. Silver may be used as an alternative disinfectant in applications in which the use of traditional disinfectants such as chlorine may result in the formation of toxic by-products or cause corrosion of surfaces. Background: While the U.S. has one of the safest food supplies in the world, food safety remains of critical importance to consumers because foodborne infec...

Plant Antimicrobial Washes for Use on Organic Leafy Greens

JianlingL@tla.arizona.edu — Thu, 17 Oct 2013 08:52:18 GMT

Faculty at the University of Arizona are developing an antimicrobial wash solution for organic leafy greens by utilizing three plant essential oil formulations. The plant oils used for this invention are food compatible, natural and considered as generally safe. This technology is highly effective against antibiotic resistant salmonella enterica on organic leafy greens than current hydrogen peroxide or chlorine treatments being used. Inventors plan to test these antimicrobial on semi-commercial scale to determine if they are equally effective and plan to investigate combinations of the antimi...

Combination Treatment for Cancer Involving CX-3543 and a PARP Inhibitor

JianlingL@tla.arizona.edu — Wed, 21 Aug 2013 11:03:47 GMT

Researchers at the University of Arizona have discovered that the addition of benzamide to HeLA cells prior to treatment with CX-3543 results in an increase in nucleolin bound to the NHE III1 element of the c-Myc promoter. Further analysis of the data indicated that there is a significant increase in the induction of apoptosis over that of CX-3543 alone. This suggests that the combined use of Cylene Pharmaceutical's CX-3543 and a PARP inhibitor should show produce greater efficacy than the use of CX-3543 alone. Also, it is anticipated that the spectrum of tumors to which this method of tr...

Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor

JianlingL@tla.arizona.edu — Thu, 18 Jul 2013 22:07:33 GMT

This invention is a dynorphin analog designed to interact with a receptor that is partly responsible for pain sensations. Dynorphin analog targets the bradykinin receptors instead of the f NMDA receptors. The ligands are novel in the deletion of an arginine residue in position 7 which has been recognized as an essential residue for opioid and non-opioid activities. This deletion has been shown to retain biological activity for the receptor. The researchers have also identified the minimum pharmacophore (combination of more than 2 basic amino acids and 2 hydrophobic amino acids) for the b...

Modified Veress Needle for Tension Pneumothorax Decompression

JianlingL@tla.arizona.edu — Wed, 20 Mar 2013 17:09:37 GMT

Inventors at the University of Arizona have developed a Modified Veress Needle (mVN) that has several design and functional advantages compared to the 14-gauge needle thoracostomy (NT) for treating tension pneumothorax (tPTX), including an indicator element to know the position of the needle. The inventors demonstrated the effectiveness of their design through a cross-over swine model of 43 tPTX events in which mVN resulted in 100% successful decompression within 70±86seconds and NT resulted in 21% successful decompression within 157±96seconds. Background: Tension pneum...

Patternable Circular Color Polarizer and Filter Based on Cholesteric Liquid Crystal Polymer

JianlingL@tla.arizona.edu — Fri, 21 Dec 2012 08:37:29 GMT

This technology consists of a process to fabricate micro-polarizer and wave plate based on nematic liquid crystals. University of Arizona inventors have improved upon that technology and have identified a process to create a circular polarizer for various visible wavelengths using a cholesteric liquid crystal (ch-LCP). Background: Linear micropolarizer arrays have been fabricated using a variety of techniques including; etched dichroic polymers, wire-grid polarizers, liquid crystal (LC) arrays, and photo aligned liquid crystal polymers (LCP). Unfortunately, these techniques are exclu...

Early Assessment of Biophysical Parameters Predicts Lesion Formation During RF Energy Delivery

JianlingL@tla.arizona.edu — Wed, 21 Nov 2012 09:17:41 GMT

Lesion size or volume prediction shortly after the beginning of an ablation procedure can inform and/or control the ablation process. The prediction and/or control is made without regard to an actual detected temperature in the vicinity of the ablation electrodes. As a consequence, the system has utility with irrigated catheter constructions and other situations in which local irrigation in the vicinity of an ablation site would otherwise interfere with a prediction or control scheme that solely relies upon temperature measurements. Background: Radio frequency ablation (RFA) is...

Compact Spatial Heterodyne Interferometer

JianlingL@tla.arizona.edu — Fri, 27 Apr 2012 10:27:59 GMT

This invention is a novel miniaturized spatial heterodyne interferometers (SHI) design that overcomes problems with thermal effects and also maintains low cost for the infrared regime. This system is a more robust SHI that can be implemented in many wavelength regimes without substantial change to the materials used. The design also has multiple implementations that allow further tradeoffs between size and costs for improved adaptability. Background: For applications where high-resolution spectral analysis is required, spatial heterodyne interferometers (SHIs) can be used for ob...

Tissue Characterization with Partial Volume Correction Using Highly Undersampled Data and a Joint Fitting Algorithm

JianlingL@tla.arizona.edu — Tue, 07 Feb 2012 15:47:59 GMT

This technology provides techniques to a fast and accurate parameter estimation in the presence of partial volume from MRI data acquired. A specific technique application for liver lesion imaging is provided in this invention. The inventors employ Joint Bi-Exponential Fitting (JBF) algorithm in context of T2 estimation for small structure determination within background, overcoming the partial volume effect. Background: While MRI technical improvements have transformed this modality for clinical application over the past 15 years, there remains a number of pressing technical requirements f...

Virtual Array Radar (VAR) Processing

JianlingL@tla.arizona.edu — Wed, 01 Feb 2012 12:20:04 GMT

This invention involves the use of angle and joint angle-range manifolds along with sparse reconstruction methods to obtain high-resolution images of man-made targets. Assuming that man-made targets are dominated by few strong scatterers, the invention sets up a reconstruction manifold based on phase histories of scatterers at different points within the illumination beam. The invention then uses a sparse reconstruction technique to obtain images of higher resolution than would typically be possible using SAR processing on the same data. The image allows better estimation of angle to the targ...

Method for Classification of Cells Based on Gene Expression

JianlingL@tla.arizona.edu — Wed, 16 Nov 2011 09:53:19 GMT

Researchers at the University of Arizona have developed methodology to characterize global gene expression within a single cell nucleus. It is envisioned that this technology will be applicable to the diagnosis of disease states in tissue or organ biopsies. It will provide signature expression patterns of normal and diseased tissue. A comprehensive image of gene expression should be particularly useful in prognosis and treatment of malignancies. Applications: Diagnosis of malignancies Determination of disease progression Applicable to diagnosis of disease states in tissue or orga...

Heat and Drought Tolerant Rice Varieties

JianlingL@tla.arizona.edu — Tue, 15 Nov 2011 14:30:32 GMT

Heat- and drought-tolerant rice varieties are under development by University of Arizona researchers under real-world conditions in Arizona and other similar stressful environments. This technology is a development of new rice varieties designed for low rainfall areas and is based on field condition evaluations and not a simulated greenhouse environment. Background: Rice is an essential food source for more than 50% of the world’s population. Heat and drought stress are important factors limiting rice production, exacerbated by the impending threat of climate change. Stress tol...

Automatic RF Match Control Circuit for Broadband and Reconfigurable Wireless Devices

JianlingL@tla.arizona.edu — Wed, 09 Nov 2011 10:28:36 GMT

The bandwidth of most wireless devices is governed by the antenna's input impedance or by the impedance match between critical devices. Often, it is the antenna's reactance rather than the resistance that varies with frequency, so tuning complex impedance to purely real impedance over a broad frequency band can be quite difficult. This invention relaxes some of the design requirements of the antenna, with an intermediate matching circuit with automatic leveling and tuning. This automatic match control circuit (AMC), which employs varactor diodes for their tunability and availability, r...

Process to Fabricate Light Sources that Emit Polarized Light

JianlingL@tla.arizona.edu — Fri, 14 Oct 2011 10:22:07 GMT

A new technology for creating polarized illumination sources that are small, have controllable spectral outputs, and that can be arranged into a microarray of polarization sources. This technology aligns molecules of photoactive dye in a liquid crystal polymer host to produce light with a degree of polarization of about 0.5. The molecules can be aligned locally across a large area to produce a micro polarization array if desired. The type of luminescent molecule used determines the source bandwidth. Background: Manipulation of light polarization is becoming increasingly important in ...

Non-Mechanical Auto-Focus and Optical Zoom

JianlingL@tla.arizona.edu — Thu, 13 Oct 2011 12:04:10 GMT

A design for a non-mechanical zoom system using variable focus elements without moving parts to create optically zoomed images has been developed by researchers at the University of Arizona. Three different magnifications have been demonstrated, and unlike digital zoom, enhanced detail is presented to the detector for improved imaging. The variable focus elements are electronically controlled using low voltages, allowing the system to be integrated readily into electronic devices. Background: Zoom systems are useful in imaging applications to collect extra-fine detail of scenes or ob...

Extremely Rapid and Fully Reprogrammable Total PCR Assays Using Wire-Guided Droplet Microfluidics

JianlingL@tla.arizona.edu — Wed, 28 Sep 2011 14:04:28 GMT

This technology comprises a reprogrammable digital microfluidics assembly, called wire-guided droplet microfluidics, wherein a droplet hangs at the end of a wire or a blunt end syringe needle and moves either over a superhydrophobic surface or within a hydrophobic liquid. The differences in the forces of adhesion to the needle wire and to the superhydrophobic surface/liquid enables the movements of a droplet following the movements of the needle wire. The wire-guided droplet microfluidics, is totally reprogrammable and simple enough to be fabricated into a handheld device that can be used in ...

Fault- and Variation-Tolerant Energy- and Area-Efficient Links for Network-on-Chips (NoCs)

JianlingL@tla.arizona.edu — Fri, 09 Sep 2011 10:52:11 GMT

Researchers in the University of Arizona's Department of Electrical and Computer Engineering developed an enhancement to the Inter-Router Dual-Function Energy and Area Efficient Links (iDEAL) design for Network-on-Chips (NoC). This development adds dynamic error correction and fault-tolerance capability to the iDEAL design scheme and overcomes many disadvantages present in traditional error-correction schemes while achieving low-latency and low power consumption. Background: This enhancement to the Inter-Router Dual-Function Energy and Area Efficient Links (iDEAL) desig...

Queral Networks

JianlingL@tla.arizona.edu — Wed, 07 Sep 2011 16:07:38 GMT

This technology is a new model of computation leveraging the power of the networked, parallelized structure of neural networks and the basic operations of computers that are termed the "Queron". The Queron would be considered a generalization of the neuron and Queral Networks a generalization of computation and ANNs. Querons are capable of connecting and listening to other Querons based on their input requirements and will allow incoming connections from other Querons in the same manner. This will allow for massive parallelization currently absent from current solutions. Ba...

Carbon Nanostructure Synthesis from Carbon-Excess Explosives in Supercrital Fluid

JianlingL@tla.arizona.edu — Thu, 30 Jun 2011 17:03:52 GMT

This invention relates to the synthesis of carbon nanostructures such as graphene, fullerenes and nano-tubes, and more particular to the synthesis of such nanostructures from carbon-excess explosives in supercritical fluid. Background: Carbon nanostructures are synthesized from carbon-excess explosives having a negative oxygen balance. A supercritical fluid provides an environment that safely dissolves and decomposes the explosive molecules into its reactant products including activated C or CO and provides the temperature and pressure for the required collision rate of activated C ...

Carbon Ion Beam Growth of Isotopically-Enriched Graphene and Isotope-Junctions

JianlingL@tla.arizona.edu — Thu, 30 Jun 2011 17:03:52 GMT

Isotopically-enriched graphene and isotope junctions are epitaxially grown on a catalyst substrate using a focused carbon ion beam technique. The focused carbon ion beam is filtered to pass substantially a single ion species including a single desired carbon isotope. The ion beam and filtering together provide a means to selectively isotopically-enrich the epitaxially grown graphene from given carbon precursor and to selectively deposit graphene enriched with different carbon isotopes in different regions. Background: Graphene is a one-atom-thick planar sheet of sp2 -bonded carbon at...

Isotope Junctions Created in Carbon Nanotubes for Spintronic Applications

JianlingL@tla.arizona.edu — Thu, 30 Jun 2011 15:56:19 GMT

This invention relates to nanotube (NT) growth of carbon and other materials using an ion implantation process, and more particular to the growth of nanotubes with a specified isotope composition using a selection filter and catalytic transmembrane. An ion source(s) is configured to generate ions from one or more elements including a plurality of different isotopes or unique molecular combinations of two or more different isotopes from at least one of the selected elements. A selection filter(s) directs a subset of the ions onto a catalytic transmembrane to grow nanotubes of a specific isotop...

NeuronMetrics: Software for Semi-Automated Processing of Cultured-Neuron Images

JianlingL@tla.arizona.edu — Fri, 17 Jun 2011 13:08:42 GMT

Thanks for your interest in NeuronMetrics. To download this software please click on the License This Technology link at right, and choose the appropriate use for commercial or academic purposes. The user manual can be downloaded at the bottom link in the right hand column. Once you have completed the license agreement you will be sent a download link and the additional files to make the software operational. This invention comprises a software tool, NeuronMetrics, which functions as a set of modules that run in the open-source program ImageJ. NeuronMetrics features a novel method fo...

Inactivation of Foodborne Pathogens by Hibiscus sabdariffa on Romaine Lettuce and Alfalfa Sprouts

JianlingL@tla.arizona.edu — Thu, 09 Jun 2011 14:29:26 GMT

Hibiscus sabdariffa (HS) is an edible plant with parts used in various applications, including foods. HS is also known for its antiseptic, diuretic, antioxidant and antimutagenic properties. Limited information is available on the antimicrobial properties against foodborne pathogens. UA researchers investigated the in vitro bactericidal effects of aqueous pastes of calyces and leaves of HS against Escherichia coli, Salmonella enterica and Listeria monocytogenes. Observations suggest that the strong bactericidal activity exhibited by the calyces and leaves of HS against E. coli, enteric...

Molecular Thermoelectric Device

JianlingL@tla.arizona.edu — Wed, 23 Mar 2011 13:27:08 GMT

Peltier coolers (which utilize the thermoelectric effect) have found their way to market very specific applications. These current devices, however, are inefficient and costly. ZT is a dimensionless figure of merit typically used to evaluate the performance of thermoelectric systems. Most of the devices mentioned above have a ZT≈1. So far, only ZT≈3 has been achieved in the lab. In order for a thermoelectric material to have broad commercial applicability, it must have a ZT≥4. The simulations and projections developed by University of Arizona researchers demonstrate that ZT>...

Fabrication of Pillared Graphene

JianlingL@tla.arizona.edu — Tue, 04 Jan 2011 08:19:22 GMT

This invention is a method of fabricating pillared graphene. This is accomplished by first constraining a layer of fullerenes between graphene sheets (the proto structure). Tether molecules may be employed to help chemically bind the fullerenes to the graphene at attachment points. Energy is applied to the proto structure via chemical reaction, thermal or radiative processes to break the carbon-carbon double bonds and open holes in the fullerenes and the graphene sheets at the attachment points. The fullerenes and graphene near the attachment points reorganize their carbon-carbon bonds v...

Process to Fabricate Micro-Polarizers and Waveplates on Sensor Array

JianlingL@tla.arizona.edu — Wed, 03 Nov 2010 09:08:28 GMT

Researchers at the University of Arizona have developed a fabrication process to create patterned polarizers for various visible wavelengths using dichroic dye in a liquid crystal polymer (LCP) host directly on an array of optical sensors. This invention uses multiple layers of an LPP/LCP system to create more complex polarization elements such as color circular polarizers, waveplates of arbitrary retardance, and linear and circular polarizers. The process is simple and inexpensive compared to other micropolarizer systems. Background: Patterned polarizers have a variety of appl...

Ultra-Compact Snapshot Imaging Fourier Transform Spectrometer

JianlingL@tla.arizona.edu — Wed, 03 Nov 2010 09:08:26 GMT

This invention is a novel device that answers challenges of increased robustness and faster acquisition time. This new device has no moving mechanical parts, mounts directly onto the focal plane imaging array, and acquires both the spectral and spatial information at once. Thus, this new device is significantly more robust than its predecessors in the field, and it offers a true snapshot capability. Its form factor is also significantly reduced with respect to its predecessors. Furthermore, due to the device’s passive design, it does not require any power to operate beyond what is ...

Very Quick Reverse Transcription Polymerase Chain Reaction for Detecting 2009 H1N1 Influenza A Using Wire-Guide Droplet Manipulations

JianlingL@tla.arizona.edu — Thu, 09 Sep 2010 14:42:26 GMT

Differential Transimpedance Amplifier Circuit for Correlated Differential Amplification

JianlingL@tla.arizona.edu — Thu, 03 Jun 2010 16:05:27 GMT

Researchers at the University of Arizona have created a differential transimpedance amplifier circuit for correlated differential amplification. The amplifier circuit increases electronic signal-to-noise ratio in charge detection circuits designed for the detection of very small quantities of electrical charge and/or very weak electromagnetic waves. A differential, integrating capacitive transimpedance amplifier integrated circuit comprising capacitor feedback loops performs time-correlated subtraction of noise. Background: When sensitive detectors are employed, their extreme sensiti...

Identification of a Novel Pollen Tube Stimulant from Arabidopsis Pistils

JianlingL@tla.arizona.edu — Wed, 10 Feb 2010 11:51:42 GMT

This patented technology is a new in vitro assay to demonstrate that diffusible factors from tissue of a pistil stimulate pollen tube germination and growth. University of Arizona researchers isolated a partially purified fraction of Arabidopsis pistil extract that promotes these activities. Utilizing molecular weight and mass spectral patterns, they predicted the chemical structure and devised a protocol to synthesize a novel compound from commercial precursors. Using an in-vitro assay, they demonstrated that the synthetic compounds mimic the natural purified fraction in stimulation of ...

Parallel Implementation of Irregular Terrain Model on NVIDIA Graphic Processing Units

JianlingL@tla.arizona.edu — Fri, 05 Feb 2010 08:52:14 GMT

To improve on the performance of Irregular Terrain Models, researchers at The University of Arizona have investigated the use of multicore processors, such as nVidia's graphics processing units (GPU's) and IBM Cell Broadband Engine (Cell BE) to achieve improved ITM performance over mainstream microprocessors. Our researchers were able to reduce the execution time of running ITM processes by a factor of 140x on the GPU platform compared to general purpose processors. Additionally, they demonstrated that by leveraging the GPU platform they were able to achieve cost savings through lower...

PV Sim - Calculator for Determining Financial Benefits of Choosing Solar Energy

JianlingL@tla.arizona.edu — Mon, 02 Nov 2009 12:14:25 GMT

PV Sim is a web-based calculator designed to supply users with relevant statistics regarding the possible financial and environmental savings of an investment in photovoltaics. This program takes users selections, combines them with pre-collected data, analyzes and instantly displays the information. This calculator comes from detailed research into the financial workings of photovoltaics and is powered by formulas developed by AzRISE. The outputs of the tool are rendered in a visually appealing, user-friendly graphic interface. The tool is fully customizable and is designed to accept a wide ...

CADDMR Technology, Providing a Cell-Based Assay for Drug Discovery for Mental Retardation Disorders

JianlingL@tla.arizona.edu — Tue, 29 Sep 2009 11:57:01 GMT

Researchers at the University of Arizona have developed a cell based assay system that can be utilized to develop a drug screen for compounds that normalize the phenotype of mutant neurons. This makes possible the development of a pharmaceutical that, when administered at a crucial stage, can effectively normalize brain development. Additionally, the system can also be used to determine which neuronal defects have occurred in patients afflicted with various developmental brain disorders. This provides physicians with the essential information utilized in deciding how to proceed with treatment...

Infectious Myonecrosis Virus (IMNV) Nucleotide Sequence, Primers for RT-PCR and a DNA Probe for In Situ Hybridization Assays for Detection of the Virus in Shrimp

JianlingL@tla.arizona.edu — Fri, 25 Sep 2009 10:41:54 GMT

University researchers have developed a rapid and sensitive method for definitive diagnosis of the disease using reverse-transcriptase polymerase chain reaction (RT-PCR). Two primer sets were used to detect 328 and 139 bp amplicons in a nested RT-PCR assay. Background: Infectious myonecrosis virus (IMNV) infecting cultured Litopenaeus vannamei, identified first in Brazil, is a double-stranded RNA virus that causes a slowly progressive disease with cumulative mortalities of up to 70%. The disease has spread to Indonesia and other shrimp aquaculture sites. The disease is commonly diagnose...

Metal Electrodes and Active Polymer Layers for Solar Cells

JianlingL@tla.arizona.edu — Mon, 31 Aug 2009 12:42:14 GMT

Researchers at the University of Arizona have developed a method for creating nanostructured electrodes that is cost effective and that also gives patterns that possess excellent uniformity. The patterns consist of conductive nano-columns that have controllable diameters and spacings. This fabrication control allows the electrodes to be tuned to possess electrical properties that are suited for many kinds of applications. These applications can range from solar cells to other solid state devices such as LED’s and batteries. Any application where electrode surface area is of concern can ...

AzCam Image Acquisition Software Package

JianlingL@tla.arizona.edu — Thu, 02 Jul 2009 14:48:57 GMT

AzCam is a control interface for scientific and industrial image acquisition hardware. This software package and data acquisition architecture is specifically designed for use at astronomical observatories, university labs, and companies with a wide range of cameras, detector configurations, and imaging characterization requirements. AzCam creates a common user interface and software tool set for both CCD and CMOS cameras. Background: This technology was developed in the Imaging Technology Laboratory (ITL) at the University of Arizona. The ITL serves as a research group within the D...

Improved User Interface for Diffraction Modeling Programs

JianlingL@tla.arizona.edu — Thu, 02 Jul 2009 14:48:56 GMT

In addition to its powerful simulation capabilities, OptiScan solves a common problem with optical simulation codes. Often it takes a significant amount of time for a student or engineer to learn how to use a either in-house or commercial programs. A unique aspect of OptiScan is its graphical user interface (GUI) that makes programming much less complicated and makes OptiScan easy to use. In one case a student started with no knowledge of the program and was producing results in less than one hour. Background: Optical data storage systems require a great deal of sophistication in th...

Infectious Begomovirus Clones

JianlingL@tla.arizona.edu — Tue, 30 Jun 2009 06:55:08 GMT

Infectious viral clones in the form of plasmid vectors are used in experimental inoculation of plants to identify resistant varieties. The varieties listed below may be purchased from the University of Arizona. List of additional varieties and references for all viruses are available upon request. Partial list of available varieties: Bean calico mosaic virus Chino del tomate virus Cotton leaf crumple virus (developed with North Carolina State University) Cotton leaf Curl Gezira virus and satellite DNA Cucurbit leaf curl virus-AZ Macroptilium mosaic Puerto Rico virus (MaMPRV) Melon ch...

Enhancing the Quality of Science and Creating a Competitive Edge: A Research Presentation for Search Committees

JianlingL@tla.arizona.edu — Wed, 24 Jun 2009 14:44:39 GMT

The work consists of an online presentation that provides evidence about how unconscious bias may influence evaluation of candidates. Designed to be presented to faculty search committees, it provides an opportunity for members to discuss how to overcome potential biases in their own processes. Online presentation tittles include the following: "Practical Tips: Deepening the Pool" "Practical Tips: Reducing/Eliminating Bias" "Interview Toolkit" "Annotated Bibliography." Content customization is possible pending further discussions with the OT...

HYD1 Peptides as Anti-Cancer Agents

JianlingL@tla.arizona.edu — Thu, 21 May 2009 13:43:49 GMT

This invention comprises the composition of HYD1 peptides which are peptides of a specific sequence composed of D amino acids that bind beta integrin and prevent cancer cells from attaching to the extracellular matrix. These peptides are useful as cancer therapeutics on their own. Also, these peptides can be combined with other therapies and be useful as a cancer diagnostic. Background: Many tumors that initially respond to chemotherapy treatments later recur, often with multi-drug resistant phenotype, due to the treatment’s failure to eliminate minimal residual disease. These...

HEK Cell Line Expressing Human FP Prostanoid Receptors

JianlingL@tla.arizona.edu — Thu, 21 May 2009 13:17:29 GMT

University of Arizona researchers have created human embryonic kidney cells expressing the human FP prostanoid receptors. These G-coupled receptors are widely found in smooth muscle such as the gastrointestinal tract and in bronchial tissue. As such, the new cell lines are expected to be a useful research tool for investigating receptor activity: they can be used in functional studies of receptor activation and second messenger signaling. They will also provide a sensitive and reliable measure of the potential for drugs to interact with the receptor. Human embryonic kidney cells were t...