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A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells
MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target...
Published: 5/7/2024
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Inventor(s): Xianchun Li
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays
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Chemistry by Design
Title: Chemistry by DesignInvention: This invention is a custom database of worldwide approved pharmaceutical structures, including the United States FDA, that are available for use via a commercial app.Background: Any substance, or mixture of substances, that is planned to be an active ingredient for a drug product is classified as an active pharmaceutical...
Published: 3/12/2024
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Inventor(s): Jon Njardarson
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Research Tools
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Optical and Acoustic Coupling Materials and Technologies
This invention describes materials and chemicals with novel, optimal optical and acoustic properties that enable or improve methods that require coupling of light and sound for biomedical and defense applications related to imaging and monitoring therapy. This invention overcomes current limitations by proposing optically and acoustically transparent...
Published: 11/16/2023
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Inventor(s): Russell Witte, Christopher Salinas, Eric Reichel
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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DNA E2E: End-to-End Programmable Microfluidic Platform (PMP) for DNA Data “Write-to-Store-to-Read” with Cold Storage of DNA Data in Synthetic Fossils and Metal-Organic Scaffolds using Supercritical Fluid (SCF) Processing
The inventors have combined an error-correcting information strategy for DNA with a supercritical fluid method for drying and storing DNA. The system features an apparatus suitable for end-to-end programmable DNA storage automation using a write-to-store-to-read data cycle via a programmable microfluidic platform (PMP). The system also features a method...
Published: 4/15/2024
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Inventor(s): Frederic Zenhausern, Devasier Bennet, Tuan Vo-Dinh, Supreya Atta
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Materials > Biocompatible
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Shrimp Viral Promoters for Gene Expression and Uses Thereof
This is a novel promoter for gene expression that can be used across species. The role animal and insect research play in the development of new medical technologies for humans is quite integral. By understanding their genetic makeup, we can learn how to improve human life. Viruses that affect crustaceans may be able to provide insight into genetic...
Published: 4/3/2023
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Inventor(s): Arun Dhar, Nam Hung Mai
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications, Technology Classifications > Agriculture & Horticulture > Aquaculture
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Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 11/16/2023
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Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
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Organoid Models of Pituitary Adenomas
This technology is a patient-derived organoid of a pituitary adenoma for the purpose of identifying treatment for Cushing’s Disease (CD). The lack of specificity of current standard of care treatments with low efficacy and tolerability makes CD a medical therapeutic challenge. One major limitation to developing new medical therapies is the lack...
Published: 11/16/2023
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Inventor(s): Yana Zavros, Andrew Little
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity
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A Device for Simultaneous Measurement of Pulmonary Ventilation and Metabolic Rate in Neonatal Rodents
University of Arizona researchers have developed a way of measuring and studying neonatal rodents' breathing activity and metabolic rate simultaneously using this homemade dual chamber technology. This inexpensive and simple tool is also useful for comparing the ventilatory and metabolic responses to various stressors, including hypoxia, acute inflammatory...
Published: 4/3/2023
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Inventor(s): Ralph Fregosi, Christina Hoyer-Kimura
Keywords(s):
Category(s): Technology Classifications > Research Tools
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Variance of Fixed Joint Space Width and Nomogram to Predict Knee Replacement using Measures from Fixed Flexion Knee X-rays
The cartilage underneath our knees keeps the bones in our legs from rubbing together. Unfortunately for many, this cartilage wears abnormally thin over time and causes physiological problems. If, however, this can be detected before it becomes a serious issue for the patient, then the patient can receive treatments before the painful problem can be...
Published: 4/3/2023
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Inventor(s): Chian Kwoh, Erin Ashbeck, Edward Bedrick, Jeffrey Duryea
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Musculoskeletal Disorders, Orthopedics/Bone, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Simulators and Modeling Tools
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Variable-Pressure Head-Out Plethysmography Chamber with Data Acquisition and Analysis Software
Animal studies have always been a large part of scientific and medical discoveries both for the animals being studied and for eventual human application. Plethysmography, studying the changes in the volume of a body or organ, is a critical part of those studies. Here specifically is the study of respiration endpoints in mice and rats given different...
Published: 4/3/2023
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Inventor(s): Kyle Kentch, Stephanie Bruggink, Benjamin Renquist
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Information Technology
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