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PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function
This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...
Published: 4/4/2024
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Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Methods of Treating Dilated Cardiomyopathy and Heart Failure
This innovation is the repurposing of drugs used for testosterone-suppression (androgen deprivation) as an innovative strategy to treat heart failure or dilated cardiomyopathy. These drugs are used for treatment of patients with advanced prostate cancer or for adolescents presenting with precocious puberty. This research is supported by published data...
Published: 4/4/2024
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Inventor(s): Guy Reed, Inna Gladysheva, Ryan Sullivan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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Pharmacological Inhibition of PD-L1 as an Antagonist of Skin Damage and Cancer in response to Acute and Chronic Solar UV Exposure and Other Environmental Toxicants
This innovation is the development of a pharmacological inhibitor of PD-L1 to prevent or reduce the negative impact of acute and chronic solar UV exposure and environmental toxicants on the skin. PD-L1 is a molecule involved in immune regulation and can be upregulated in response to UV radiation and environmental toxins. However, overexpression of PD-L1...
Published: 3/6/2024
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Inventor(s): Sally Dickinson, Georg Wondrak, Clara Curiel
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Compounds as TDP-43 LLPS Modulators
This technology provides compounds and pharmaceutical compositions comprising small molecules that inhibit the formation of TAR DNA-binding protein 43 (TDP-43) condensates, which are protein aggregates linked to various neurodegenerative diseases including Alzheimer’s disease. By suppressing the formation of these aggregates, these molecules improve...
Published: 2/19/2024
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Inventor(s): Xinglong Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Broad Applications of PROTACS for Targeted Protein Degradation Employing a Molecular Glue-Linker-Warhead Approach
This technology is a high-affinity E3-ligase binder, which has been optimized toward the specific proteolysis targeting chimera (PROTAC) mediated degradation of particular proteins. A PROTAC is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. This technology opens the door for...
Published: 2/6/2024
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Inventor(s): Christopher Hulme, Kevin Schofield
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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New Deuterated Amino Acid Derivatives
Compositions and method of making involve use of alternative acids as reactants instead of carboxylic acids which produces deuterated amino acids, while carboxylic acids can only synthesize alkyl amino acids. Introducing deuterium to amino acids and derivatives improves biologically active compounds and therapeutics. Modification improves properties...
Published: 1/16/2024
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Inventor(s): Wei Wang, Yue Dong
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences
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Phenyllactic Acid: Antimicrobial Activity against Vaginal Microbiota and Cytotoxic Properties on Human Cervical Epithelial Cells
Researchers at the University of Arizona investigated the antimicrobial properties of Phenyllactic Acid (PLA) derivatives against both commensal and Bacterial vaginosis (BV)-associated bacteria, as well as their cytotoxic effects on human cervical epithelial cells. PLA is a broad-spectrum antimicrobial compound produced by vaginal Lactobacillus species;...
Published: 1/16/2024
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski, Abhijit Date, Phoebe Crossley
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Polymeric Valve for Tricuspid Applications
This invention is a medical implant that is made of polymeric and metallic materials that functions as a replacement valve for tricuspid applications. The valve functions as a flow regulator and can be installed in low pressure, low flow, and low shear cardiovascular structures. It is specifically engineered to reduce stress on the implant structure...
Published: 1/16/2024
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Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices > Therapeutic
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Bioorthogonal Activation of PROTAC Prodrugs
Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and...
Published: 1/16/2024
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Inventor(s): Wei Wang, Mengyang Chang, Giri Gnawali
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Rotational Force-Induced Brain Injury Model
This innovation is a new instrument, model, and treatment for repetitive rotational head trauma in rodents that demonstrates the acute and prolonged pathological, behavioral, and electrophysiological effects of rotational traumatic brain injury (rTBI). Aberrant Cyclin-dependent kinase 5 (Cdk5) activity is a principal mediator of rTBI. Cdk5-enriched...
Published: 1/16/2024
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Inventor(s): James Bibb, Alan Umfress
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Life Sciences > Therapeutics
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