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Intracranial and Cerebrospinal Fluid Deuteration using Heavy Water Isotopologues
This invention is a method of therapeutic intervention for primary and metastatic brain cancer, and other relevant nervous system derivates, via the deliverances of deuterated heavy water isotopologue. This novel treatment method offers promise for specificity improvements as it uses water to deliver its therapy, allowing for increased efficiency in...
Published: 3/3/2025
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Inventor(s): Georg Wondrak, Jana Jandova
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
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Pharmacological Inhibition of PD-L1 as an Antagonist of Skin Damage and Cancer in response to Acute and Chronic Solar UV Exposure and Other Environmental Toxicants
This innovation is the development of a pharmacological inhibitor of PD-L1 to prevent or reduce the negative impact of acute and chronic solar UV exposure and environmental toxicants on the skin. PD-L1 is a molecule involved in immune regulation and can be upregulated in response to UV radiation and environmental toxins. However, overexpression of PD-L1...
Published: 3/21/2025
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Inventor(s): Sally Dickinson, Georg Wondrak, Clara Curiel
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Design and Development of Innovative Formulations of Resatorvid for Targeted Skin Drug Delivery and Applications Therein
University of Arizona researchers have developed a novel formulation of Resatorvid, a selective TLR4 inhibitor that was originally designed for the treatment of sepsis. This re-formulation is designed for delivery to the skin for a variety of skin diseases including early stages of skin cancer.
Background:
Skin cancers tend to be slow growing and can...
Published: 3/21/2025
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Inventor(s): Heidi Mansour, Victor Ruiz, Sally Dickinson, Clara Curiel, Hsiao-Hui Chow, Georg Wondrak
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Natural Treatment for Ventilation Induced Lung Injury
This invention is the use of bixin, a NRF2 inducer, to reduce lung damage caused by mechanical ventilation. Bixin was found to suppress inflammatory mediators, reduce alveolar capillary leakage, and protect against DNA oxidative damage.
Background:
Mechanical ventilation is used to assist patients who have difficulty breathing spontaneously in conditions...
Published: 3/21/2025
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Inventor(s): Donna Zhang, Georg Wondrak, Joe Garcia, Ting Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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