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Pharmacological Inhibition of PD-L1 as an Antagonist of Skin Damage and Cancer in response to Acute and Chronic Solar UV Exposure and Other Environmental Toxicants
This innovation is the development of a pharmacological inhibitor of PD-L1 to prevent or reduce the negative impact of acute and chronic solar UV exposure and environmental toxicants on the skin. PD-L1 is a molecule involved in immune regulation and can be upregulated in response to UV radiation and environmental toxins. However, overexpression of PD-L1...
Published: 3/6/2024
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Inventor(s): Sally Dickinson, Georg Wondrak, Clara Curiel
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Design and Development of Innovative Formulations of Resatorvid for Targeted Skin Drug Delivery and Applications Therein
University of Arizona researchers have developed a novel formulation of Resatorvid, a selective TLR4 inhibitor that was originally designed for the treatment of sepsis. This re-formulation is designed for delivery to the skin for a variety of skin diseases including early stages of skin cancer.
Background:
Skin cancers tend to be slow growing and can...
Published: 11/16/2023
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Inventor(s): Heidi Mansour, Victor Ruiz, Sally Dickinson, Clara Curiel, Hsiao-Hui Chow, Georg Wondrak
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Natural Treatment for Ventilation Induced Lung Injury
This invention is the use of bixin, a NRF2 inducer, to reduce lung damage caused by mechanical ventilation. Bixin was found to suppress inflammatory mediators, reduce alveolar capillary leakage, and protect against DNA oxidative damage.
Background:
Mechanical ventilation is used to assist patients who have difficulty breathing spontaneously in conditions...
Published: 11/16/2023
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Inventor(s): Donna Zhang, Georg Wondrak, Joe Garcia, Ting Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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