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Method of Treating Acute Lung Injury Using Sphingosine 1 Phosphate Analogs Or Sphingosine 1 Phosphate Receptor Agonists
This invention describes a method to treat and reduce the risk for acute lung injury (ALI) associated with radiation, infection, trauma, and other environmental-related lung injury. The method described involves the administration of analogs or derivatives of a Sphingosine 1 Phosphate (S1P) receptor agonists that have similar properties of S1P that...
Published: 4/3/2023
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Inventor(s): Joe Garcia, Steven Dudek
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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eNAMPT mAb for Treatment of Acute Cardiac Ischemia and Infarction
This invention is a highly novel theranostic target, extracellular nicotinamide phosphoribosyl-transferase (eNAMPT), that can afford specific detection and treatment of post-infarct inflammation-mediated myocardial injury based on an eNAMPT-neutralizing humanized monoclonal antibody (mAb).
Background:
Worldwide, cardiovascular diseases are responsible...
Published: 7/6/2023
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Inventor(s): Joe Garcia, Diego Martin, Zhonglin Liu
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Natural Treatment for Ventilation Induced Lung Injury
This invention is the use of bixin, a NRF2 inducer, to reduce lung damage caused by mechanical ventilation. Bixin was found to suppress inflammatory mediators, reduce alveolar capillary leakage, and protect against DNA oxidative damage.
Background:
Mechanical ventilation is used to assist patients who have difficulty breathing spontaneously in conditions...
Published: 11/16/2023
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Inventor(s): Donna Zhang, Georg Wondrak, Joe Garcia, Ting Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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Expression of Nicotinamide Phosphoribosyltransferase Mediated Genes Predicts Recurrence-free Survival in Lung and Breast Cancers
The technology is a prognostic cancer gene assay for lung and breast cancer that utilizes a new biomarker. The technology fills a current need for better prognosis tools for triple negative breast cancer tumors and provides a new discovery in gene expression profiling.
Background:
This biomarker, NAMPT (nicotinamide phosphoribosyltransferase), is...
Published: 4/3/2023
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Inventor(s): Joe Garcia
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics
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