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Stroke Outcome Prediction Using Vascular Imaging Features and Machine Learning
This technology is a stroke outcome prediction method to determine patient outcomes and inform treatment decisions. The method utilizes machine learning models trained with patient-specific vascular imaging features, patient demographics, stroke severity scores and clinical history as predictors to forecast a 90-day functional outcome following an ischemic...
Published: 4/23/2024
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Inventor(s): Aditi Deshpande, Kaveh Laksari, Jordan Elliott, Pouya Tahsili-Fahadan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Compounds as TDP-43 LLPS Modulators
This technology provides compounds and pharmaceutical compositions comprising small molecules that inhibit the formation of TAR DNA-binding protein 43 (TDP-43) condensates, which are protein aggregates linked to various neurodegenerative diseases including Alzheimer’s disease. By suppressing the formation of these aggregates, these molecules improve...
Published: 2/19/2024
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Inventor(s): Xinglong Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Rotational Force-Induced Brain Injury Model
This innovation is a new instrument, model, and treatment for repetitive rotational head trauma in rodents that demonstrates the acute and prolonged pathological, behavioral, and electrophysiological effects of rotational traumatic brain injury (rTBI). Aberrant Cyclin-dependent kinase 5 (Cdk5) activity is a principal mediator of rTBI. Cdk5-enriched...
Published: 1/16/2024
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Inventor(s): James Bibb, Alan Umfress
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Life Sciences > Therapeutics
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Discovery of Novel DYRK1A Inhibitors
DYRK1A has been implicated in multiple disease states, including Alzheimer's Disease and Down Syndrome. Researchers have discovered a new chemotype that has been exemplified with significant DYRK1A activity and have developed brain-penetrant small molecule DYRK1A inhibitors toward Alzheimer's and the cognitive deficits of Down Syndrome. Future...
Published: 1/10/2024
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Inventor(s): Christopher Hulme, Timothy Chavez, Nathan Bedard
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal
This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive...
Published: 3/12/2024
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Inventor(s): John Streicher, Robin Polt, Lajos Szabo, Wafaa Alabsi, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology
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Glycopeptide-Lipid Supramolecular Assembly
This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...
Published: 3/12/2024
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Inventor(s): Robin Polt, Michael Heien
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology
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Plasma from Mouse Stroke Model that can be used to detect Neurofilament Light Chain
This invention relates to the intellectual property that consists of a stored archive of hundreds of mouse blood plasma samples that were taken from a laboratory stroke model for mice under various conditions of the mice age and the time past stroke. By evaluating the quantity of neurofilament light (NfL) chain (protein) within the samples they can...
Published: 3/12/2024
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Inventor(s): Kristian Doyle, Jennifer Frye
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology
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Stroke Outcome Prediction using Vascular Imaging Features
This is a prediction method to determine the outcome of a stroke based on vascular images presented by the patient. This model predicts the 90-day functional outcome after ischemic stroke at a significantly higher accuracy than current models, to inform treatment decisions and patient selection. Machine learning models were employed and trained with...
Published: 2/1/2024
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Inventor(s): Kaveh Laksari, Aditi Deshpande, Jordan Elliott, Pouya Tahsili-Fahadan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics
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Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 11/16/2023
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Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
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