|
Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal
This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive...
Published: 3/12/2024
|
Inventor(s): John Streicher, Robin Polt, Lajos Szabo, Wafaa Alabsi, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology
|
|
Novel Peptides Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment
Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable...
Published: 3/12/2024
|
Inventor(s): Lajos Szabo, Robin Polt, John Streicher, Michael Heien, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
|
|
Glycolipid and Mixed Micelle Characterization via Diffusion-Ordered Spectroscopy
This invention is a spectroscopy method to measure and observe solutions such as aggregates for the purpose of characterizing glycolipid surfactants.
Background:
Surfactants are known compounds that lower surface tension between two liquids, or a liquid and a solid, with application in detergents, wetting agents, foams, etc. Most industrial surfactants...
Published: 3/12/2024
|
Inventor(s): Dillon Hanrahan, Lajos Szabo, Robin Polt, Michael Heien, Chenxi Liu
Keywords(s):
Category(s): Technology Classifications > Materials, Technology Classifications > Research Tools
|
|
Glycopeptide and Classical Drug Design
This invention relates to the glycosylation drug candidates to increase penetration, bioavailability, and stability.
Background:
Transmembrane proteins provide a pathway for drugs to interact with a cell's interior. Drugs commonly target G-protein coupled receptors (GPCRs), comprising 40% of the market. Peptides and small molecule drugs directed...
Published: 3/12/2024
|
Inventor(s): Robin Polt, Christopher Apostol, Michael Heien, Chenxi Liu, John Streicher, Lajos Szabo, Torsten Falk
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery
|
