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Glycopeptide-Lipid Supramolecular Assembly
This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...
Published: 6/20/2024
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Inventor(s): Robin Polt, Michael Heien
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology
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Novel Peptides Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment
Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable...
Published: 3/12/2024
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Inventor(s): Lajos Szabo, Robin Polt, John Streicher, Michael Heien, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Portable Low-Cost System for Field Chemical Analysis
This invention describes a portable, low cost, system incorporating a compact potentiostat for electrochemical analytical chemistry measurements. The system can run on five-volt batteries and stores data that can be readily exported.
Background:
Measurement science has continually evolved since the introduction of the operational amplifier, the...
Published: 3/12/2024
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Inventor(s): Michael Heien, Drew Farrell
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Electronics, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation
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Glycolipid and Mixed Micelle Characterization via Diffusion-Ordered Spectroscopy
This invention is a spectroscopy method to measure and observe solutions such as aggregates for the purpose of characterizing glycolipid surfactants.
Background:
Surfactants are known compounds that lower surface tension between two liquids, or a liquid and a solid, with application in detergents, wetting agents, foams, etc. Most industrial surfactants...
Published: 3/12/2024
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Inventor(s): Dillon Hanrahan, Lajos Szabo, Robin Polt, Michael Heien, Chenxi Liu
Keywords(s):
Category(s): Technology Classifications > Materials, Technology Classifications > Research Tools
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Glycopeptide and Classical Drug Design
This invention relates to the glycosylation drug candidates to increase penetration, bioavailability, and stability.
Background:
Transmembrane proteins provide a pathway for drugs to interact with a cell's interior. Drugs commonly target G-protein coupled receptors (GPCRs), comprising 40% of the market. Peptides and small molecule drugs directed...
Published: 3/12/2024
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Inventor(s): Robin Polt, Christopher Apostol, Michael Heien, Chenxi Liu, John Streicher, Lajos Szabo, Torsten Falk
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery
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Measuring Blood Brain Barrier Permeation of Peptides
This method enables quantifying the blood brain barrier (BBB) penetration of endogenous opioid peptides, such as enkaphalins, endorphins, dynorphins, nociceptin, and endomorphins. A measurement system uses a fluidic system and the use of preservative agents to prevent enzymatic degradation of peptides to be measured.
Background:
Neurological compounds...
Published: 6/20/2024
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Inventor(s): Michael Heien, Nicholas Laude, Catherine Kramer
Keywords(s):
Category(s): Technology Classifications > Sensors & Controls > Biologic
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Glycosylation of Secretin Peptides to Improve Drug-Like Properties
This invention is the development of pituitary adenylate cyclase activating peptide (PACAP) agonists for neuroprotection and antagonists for migraine.
Background:
PACAP is known as a neuronal survival factor, regulating the development, maintenance, function, and plasticity of neurons through activating PAC1, VPAC1, and VPAC2 receptors. Glycosylated...
Published: 6/20/2024
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Inventor(s): Robin Polt, Evan Jones, Bobbi Anglin, Michael Heien, John Streicher
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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