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This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects. Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides,...

Published: 3/12/2024 | Inventor(s): Robin Polt, Evan Jones

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Glycosylation of Secretin Peptides to Improve Drug-Like Properties

This invention is the development of pituitary adenylate cyclase activating peptide (PACAP) agonists for neuroprotection and antagonists for migraine. Background: PACAP is known as a neuronal survival factor, regulating the development, maintenance, function, and plasticity of neurons through activating PAC1, VPAC1, and VPAC2 receptors. Glycosylated...

Published: 6/20/2024 | Inventor(s): Robin Polt, Evan Jones, Bobbi Anglin, Michael Heien, John Streicher

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences