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PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function
This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...
Published: 4/4/2024
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Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Fluorinated Poly (β-Amino Ester) Nanoparticle for Highly Efficient and Specific Delivery of Nucleic Acids to the Lung Capillary Endothelium
This technology describes nanoparticles with specific structure design and modification for high efficiency and specific delivery of nucleic acids to the pulmonary endothelial cells. After intravenous administration, the nanoparticles were capable of delivering non-integrating DNA plasmids to lung microvascular endothelial cells but not to other lung...
Published: 2/6/2024
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Inventor(s): Zicheng Deng, Vladimir Kalinichenko, Donglu Shi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Drug Delivery
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Enhancing Absorption of Dietary Compounds to Promote Health
This innovation is directed to oral co-administration of glucuronidase and polyphenols for reabsorption in the gut. Glucuronidase are enzymes that can be made or derived from any source such as bacteria, recombinant, species agnostic, and others. The inactive glucuronides are cleared from the body by secretion back into the gastrointestinal track where...
Published: 10/2/2023
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Inventor(s): Janet Funk
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Healthcare Portfolios
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Novel Modalities for the Treatment of Cryptococcal Meningitis
This invention is the repurposing of oxfendazole, an FDA-approved veterinary anthelmintic benzimidazole and its novel oral bioavailability enhancing formulations for the oral treatment of cryptococcal meningitis. The oxfendazole ionic liquid containing nano formulations can lead to the development of low-cost oral treatment for cryptococcal meningitis.
Background:...
Published: 11/16/2023
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Inventor(s): Abhijit Date, Yogesh Sutar, Kirsten Nielsen
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Drug Delivery
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Biocompatible Ionic Liquids for Improving Delivery of Therapeutic Agents
This invention relates to three types of ionic liquids (ILs) that will improve the delivery of a diverse array of therapeutic agents. The first type of ILs consists of a drug as either cation or anion and a biocompatible counterion to improve the aquas or solubility and permeability of drugs and to facilitate the incorporation of these ILs into various...
Published: 11/16/2023
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Inventor(s): Abhijit Date, Yogesh Sutar
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics
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Scalable Synthesis for Commercial Production of Carbohydrate-Based Molecular Scaffold Compounds for Direct Delivery of Drugs or Nutritional Supplements to the GI Tract
This invention provides a scalable synthesis method for commercial production (kilogram and greater) of novel carbohydrate-based molecular scaffold compounds for various therapeutic and diagnostic applications that have been and are being developed by UArizona inventors. Oral administration and targeted delivery of pro-drugs or other payloads, such...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr.
Keywords(s):
Category(s): Technology Classifications > Materials > Processing, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Nutraceuticals
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Method and System for Passive and Active Agent Delivery for Biomarker and Treatment Means
Plant-based extracellular vesicles have features leading to low immunogenicity with innate bioactive agents for targeting and/or treating specific biological effects. They can also be used as carriers with cargo drug from natural or synthetic products with higher bioavailability. The variety of plant categories also provide broad resources for lower...
Published: 11/16/2023
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Inventor(s): Frederic Zenhausern, Jerome Lacombe, Ashlee Harris, Zhu Zhao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Drug Delivery
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Glycopeptide-Lipid Supramolecular Assembly
This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...
Published: 3/12/2024
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Inventor(s): Robin Polt, Michael Heien
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology
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Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors
This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors.
Background:
Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health...
Published: 4/3/2023
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Inventor(s): Samantha Harris
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences
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A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker.
Background:
Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 11/16/2023
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Inventor(s): Rajesh Khanna, Jun Wang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
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