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Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres

This technology is designed to relate to myosin binding protein-C (MyBP-C), more particularly to methods and compositions for modifying MyBP-C in sarcomeres, e.g., protein engineering for studying MyBP-C in sarcomeres. It is an objective of the present invention to provide methods and compositions that allow for a single gene-edited mouse model that...

Published: 6/6/2024 | Inventor(s): Samantha Harris

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Category(s): Technology Classifications > Life Sciences

Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors

This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors. Background: Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health...

Published: 7/26/2024 | Inventor(s): Samantha Harris

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Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences

A Cut and Paste Method for Modification of cMyBP-C in Muscle Sarcomeres

This technology utilizes unique “spy” proteins, allowing researchers to effectively “cut and paste” desired cMyBP-C sequences that could include a variety of modifications such as point mutations and FRET probes. This method makes the manipulation of cMyBP-C in thick filaments a lot easier. Background: cMyBP-C is an essential...

Published: 6/6/2024 | Inventor(s): Samantha Harris

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Category(s): Technology Classifications > Research Tools