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PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function
This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...
Published: 4/4/2024
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Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Methods of Treating Dilated Cardiomyopathy and Heart Failure
This innovation is the repurposing of drugs used for testosterone-suppression (androgen deprivation) as an innovative strategy to treat heart failure or dilated cardiomyopathy. These drugs are used for treatment of patients with advanced prostate cancer or for adolescents presenting with precocious puberty. This research is supported by published data...
Published: 4/4/2024
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Inventor(s): Guy Reed, Inna Gladysheva, Ryan Sullivan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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Polymeric Valve for Tricuspid Applications
This invention is a medical implant that is made of polymeric and metallic materials that functions as a replacement valve for tricuspid applications. The valve functions as a flow regulator and can be installed in low pressure, low flow, and low shear cardiovascular structures. It is specifically engineered to reduce stress on the implant structure...
Published: 1/16/2024
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Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices > Therapeutic
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Heart Valve for Eccentric Orifice
This technology is a novel heart valve and deployment system that maintains eccentric geometries while optimizing valve function and hemodynamics, reducing adverse events. The asymmetrical leaflet design features two identical mirrored larger leaflets and one shorter leaflet. Traditional symmetric leaflet design features three equal leaflets that rely...
Published: 11/16/2023
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Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic, Ryan Helbock
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Therapeutic, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Polymeric Heart Valve System and Method of Manufacture
This invention is a new polymer-based heart valve designed to reduce stress on the leaflets of the valve while in use in the human body, providing for longer-term durability compared to other polymer-based valves.
Background:
According to the CDC, heart disease is the leading cause of death in the United States: about one in every four deaths is due...
Published: 11/16/2023
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Inventor(s): Marvin Slepian, Danny Bluestein, Oren Rotman, Brandon Kovarovic
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Medical Devices
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Genetically Engineered Recombinant Proteins for Functional Regenerative Tissue Scaffolds
This technology encompasses the development of recombinant tissue-specific proteins that are used to produce hydrogel scaffolds that mimic the structure of natural tissues and are therefore able to harness the function of the tissues. Each protein sequence is able to be precisely customized, which allows the tissues to be biocompatible and efficient...
Published: 2/1/2024
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Inventor(s): Minkyu Kim, David Knoff
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Interactive Deep Learning for ECG Monitoring
This invention is a deep learning algorithm system that can incorporate human-interpretable explanations in its training process for the analysis of ECG signals. This method takes into account classification loss, the influence of unimportant features to model prediction, the influence of important features to model prediction, and user feedback. This...
Published: 3/12/2024
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Inventor(s): Chicheng Zhang, Dharma KC, Christopher Gniady, Parth Agarwal
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Software & Information Technology > Health IT
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High Bandwidth Positive Displacement Reversible Pump/Motor
This invention is a pump system developed to serve as an artificial heart. This is an electrically driven device without fixed valves that functions with "functional equivalents" of valves via a sliding vane. The vane serves to propel flow as well as to partition flow. A high bandwidth positive displacement reversible pump/motor with two embodiments...
Published: 11/16/2023
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Inventor(s): Marvin Slepian, Mengtang Li, Eric Barth
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic
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A Peptide Approach to Block eNOS Phosphorylation at T495
This invention is a peptide that blocks eNOS phosphorylation. These peptides are designed to target to block T495 phosporylation site of eNOS. When done, this would prevent the activation of eNOS that leads to superoxide production and overwhelming inflammation. The initial peptide has been shown to reduce NOS derived superoxide and cell barrier loss...
Published: 4/3/2023
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Inventor(s): Stephen Black, Evgeny Zemskov, Qing Lu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Biologics
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Affinity Peptide Conjugated with Antioxidant for Protection of Proteins from Oxidation
This invention is a targeted peptide conjugated with an antioxidant to inhibit Akt1 nitration. It can be utilized for treating pulmonary arterial hypertension (PAH) with potential application in other abnormal proliferative disorders such as cancer.
Background:
Pulmonary arterial hypertension (PAH) is a disorder affecting 1.1 to 17.6 million adults...
Published: 4/3/2023
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Inventor(s): Ruslan Rafikov, Olga Rafikova
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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