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Peptides Targeting Inositols Mediated Proliferative Signaling for Treating Cancers and other Proliferative Disorders
This invention describes a method that efficiently stops the growth of cancer cells or over-proliferative cells without causing adverse cytotoxic effects on the body’s healthy organs and tissues. This technology focuses on the IMPA1/RAGE complex and its ability to control cell proliferation.
Background:
Proliferative disorders include a wide...
Published: 4/3/2023
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Inventor(s): Olga Rafikova, Ruslan Rafikov
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios
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Peptide-Based Modulators of HMGBl Activity Protect Against Cell Damage and Inflammation
This technology assists with the inhibition of HMGB1 to decrease the body’s inflammatory response, which occurs when the HMGB1 protein binds to DNA and TLR4. By decreasing HMGB1 binding to DNA, cell inflammation can be significantly reduced, thus preventing further cell damage. This technology can be used in a large spectrum of diseases, such...
Published: 8/16/2023
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Inventor(s): Ruslan Rafikov, Olga Rafikova
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
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Affinity Peptide Conjugated with Antioxidant for Protection of Proteins from Oxidation
This invention is a targeted peptide conjugated with an antioxidant to inhibit Akt1 nitration. It can be utilized for treating pulmonary arterial hypertension (PAH) with potential application in other abnormal proliferative disorders such as cancer.
Background:
Pulmonary arterial hypertension (PAH) is a disorder affecting 1.1 to 17.6 million adults...
Published: 4/3/2023
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Inventor(s): Ruslan Rafikov, Olga Rafikova
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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Genetic Rat Model for Pulmonary Hypertension
This technology is a genetic rat model with a human mutation that allows for the study of pulmonary hypertension. This new model is ideal for studying the contribution of mitochondrial dysfunction that occurs in the development and progression of pulmonary hypertension.
Background:
Pulmonary hypertension (PH) is an increase in blood pressure within...
Published: 4/3/2023
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Inventor(s): Ruslan Rafikov, Olga Rafikova
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models
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