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PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function

This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...

Published: 4/4/2024 | Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt

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Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular

Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal

This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive...

Published: 3/12/2024 | Inventor(s): John Streicher, Robin Polt, Lajos Szabo, Wafaa Alabsi, Parthasaradhi Reddy Tanguturi

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology

Glycopeptide-Lipid Supramolecular Assembly

This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...

Published: 3/12/2024 | Inventor(s): Robin Polt, Michael Heien

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Novel Peptides Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment

Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable...

Published: 3/12/2024 | Inventor(s): Lajos Szabo, Robin Polt, John Streicher, Michael Heien, Parthasaradhi Reddy Tanguturi

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Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Glycolipid and Mixed Micelle Characterization via Diffusion-Ordered Spectroscopy

This invention is a spectroscopy method to measure and observe solutions such as aggregates for the purpose of characterizing glycolipid surfactants. Background: Surfactants are known compounds that lower surface tension between two liquids, or a liquid and a solid, with application in detergents, wetting agents, foams, etc. Most industrial surfactants...

Published: 3/12/2024 | Inventor(s): Dillon Hanrahan, Lajos Szabo, Robin Polt, Michael Heien, Chenxi Liu

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Category(s): Technology Classifications > Materials, Technology Classifications > Research Tools

Carbohydrate-Based Surfactants and Methods of Production

This invention is a method to produce carbohydrate-based surfactants with repeated succession using a glycosylation promotor. Background: Current amphiphilic molecules, surfactants, emulsifiers, cleaning products and food additives are mostly made from synthetic surfactants. Commonly these surfactants are prepared from petroleum-based materials...

Published: 6/30/2023 | Inventor(s): Jeanne Pemberton, Robin Polt, Raina Maier, Ricardo Palos Pacheco

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Category(s): Technology Classifications > Life Sciences > Nutraceuticals

Glycopeptide and Classical Drug Design

This invention relates to the glycosylation drug candidates to increase penetration, bioavailability, and stability. Background: Transmembrane proteins provide a pathway for drugs to interact with a cell's interior. Drugs commonly target G-protein coupled receptors (GPCRs), comprising 40% of the market. Peptides and small molecule drugs directed...

Published: 3/12/2024 | Inventor(s): Robin Polt, Christopher Apostol, Michael Heien, Chenxi Liu, John Streicher, Lajos Szabo, Torsten Falk

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery

Pseudoprolines in Neuropeptides

This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects. Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides,...

Published: 3/12/2024 | Inventor(s): Robin Polt, Evan Jones

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Glycosylation of Secretin Peptides to Improve Drug-Like Properties

This invention is the development of pituitary adenylate cyclase activating peptide (PACAP) agonists for neuroprotection and antagonists for migraine. Background: PACAP is known as a neuronal survival factor, regulating the development, maintenance, function, and plasticity of neurons through activating PAC1, VPAC1, and VPAC2 receptors. Glycosylated...

Published: 3/12/2024 | Inventor(s): Robin Polt, Evan Jones, Bobbi Anglin, Michael Heien, John Streicher

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences