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Fluorinated Poly (β-Amino Ester) Nanoparticle for Highly Efficient and Specific Delivery of Nucleic Acids to the Lung Capillary Endothelium

This technology describes nanoparticles with specific structure design and modification for high efficiency and specific delivery of nucleic acids to the pulmonary endothelial cells. After intravenous administration, the nanoparticles were capable of delivering non-integrating DNA plasmids to lung microvascular endothelial cells but not to other lung...

Published: 2/6/2024 | Inventor(s): Zicheng Deng, Vladimir Kalinichenko, Donglu Shi

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Drug Delivery

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools