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A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells
MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target...
Published: 5/7/2024
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Inventor(s): Xianchun Li
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays
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CPS1 Markerless Deletion Mutant as a Method for Marker Deletion
This technology involves a novel system using a two-step process to eliminate a gene of interest by incorporating a “suicide gene” vector system. The construct created by this method results with no foreign sequences, making the strains markerless mutants. This means that one has the potential to make genetic strains with multiple mutations...
Published: 4/23/2024
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Inventor(s): Maria Alejandra Mandel, Marc Orbach
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools > Screening assays
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Fluorophore-Doped Metal-Organic Frameworks for Quantifying Low-Energy Radionuclides in Aqueous Solutions
This technology represents a new class of scintillation materials based on metal organic frameworks (MOFs), highly crystalline and tunable structures, which may provide higher detection efficiency compared to other particle scintillation materials. Furthermore, the use of fluorophores with these MOFs paves the way for more versatile applications in...
Published: 4/10/2024
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Inventor(s): Craig Aspinwall, Chen-Yi Ke, Brian Zacher
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Agricultural Engineering, Technology Classifications > Energy, Cleantech & Environmental > Remediation, Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation
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Reversible Crosslinking to Preserve Cell-Specific Gene Expression Across Biospheres
This invention includes chemical methods and reagents to reversibly immobilize the cellular state of gene expression in the field followed by the release of the immobilization in the laboratory for analysis of the gene expression state. Support for this invention was provided by CALS via the Hatch allocation.
Background:
Characterization of single-cell...
Published: 4/3/2023
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Inventor(s): David Galbraith
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays
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Design and Application of Novel Ligand-Induced Split-Protein Systems
This invention is a split protein system that functions as a biotechnological chemically-induced dimerization (CID) tool. These CID systems are useful for biological research to control numerous outputs in living organisms such as inducing the activation of a specific protein, protein localization, and inducing transcription. This novel CID system...
Published: 3/12/2024
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Inventor(s): Indraneel Ghosh, Samuel Sugerman, Brittany Stankavich
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays
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Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
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Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
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Demultiplex Single-Cell Sequencing Data using DNA Barcode Dyes
This technology applies to single cell RNA sequencing data that is created in parallel (multiplexed) to speed the process. Once the multiplexed data exists, it needs to be recombined into one set (demultiplexed) to be useful. This technology is a new demultiplexing technique that uses dyes combined with DNA barcodes, simplifying the demultiplexing process.
Background:
RNA...
Published: 4/3/2023
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Inventor(s): Jared Churko
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
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Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides
Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Chen-Yi Ke, Minhui Han, Brian Zacher
Keywords(s):
Category(s): Technology Classifications > Materials > Nanomaterials, Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Reagents, Technology Classifications > Medical Devices > Diagnostic
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Novel Mechanism Anti-Fungal with High Specificity
University of Arizona researchers have discovered a novel approach for treating fungal or yeast infections using a previously unstudied GPCR-like protein, which is integral to the regulation of cell growth in yeast cells. This protein and metabolic pathway is absent in higher-order animals, which provides a novel pathway for drugs to stop the growth...
Published: 3/12/2024
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Inventor(s): Andrew Capaldi, Ryan Wallace, Eric Lu
Keywords(s):
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 3/12/2024
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Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
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