|
Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling...
Published: 10/17/2024
|
Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge, Indraneel Ghosh, Danielle Johnson, Abigail Shepard
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
|
|
Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazine Reagents
The invention includes triazines for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc. Application of UV light at neutral pH releases diazonium species, which can be used in a wide variety of applications, including protein...
Published: 8/26/2024
|
Inventor(s): Garrett Davis, John Jewett
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents
|
|
Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 3/12/2024
|
Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
|
|
Shelf-Stable Reagent for Bioconjugation and Protein Labeling
This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...
Published: 6/20/2024
|
Inventor(s): John Jewett, Garrett Davis, Holly Sofka
Keywords(s):
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics
|
|
pH Releasable Linkers for Drug Delivery, Imaging, or Diagnostics
This technology describes water-soluble triazabutadienes as cross-linkers to and protecting groups for small-molecule therapeutics or fluorescent moieties. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling targeted delivery of the cross-linked molecule.
Background:
Cross linking is becoming...
Published: 11/4/2024
|
Inventor(s): John Jewett, Flora Kimani
Keywords(s): diagnostic tool
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
|
|
Triazabutadienes as Cleavable Protein Linkers
This technology describes water-soluble triazabutadienes as cleavable cross linkers. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling delivery of the cross-linked molecule.
Background:
Cross linking is becoming a valuable practice in chemistry, including for life science applications, with...
Published: 6/20/2024
|
Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani, Brandon Cornali
Keywords(s):
Category(s): Technology Classifications > Materials > Polymers
|
|
Quantitative Detection of Protein Misfolding or Aggregation by Chemical Labeling
This invention describes methods and systems for detecting, comparing, or evaluating proteins in a folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 6/20/2024
|
Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour, Mehrdad Shadmehr
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Medical Devices > Diagnostic
|
|
Underwater Adhesives
This technology provides a method for underwater adhesion through the use of a masked compound that, when exposed to water, forms covalent bonds with surfaces containing phenols.
Background:
It is extremely difficult to repair cracked or broken surfaces that are exposed to water (i.e. boat hulls, swimming pools, human tissues, etc.) without the...
Published: 3/12/2024
|
Inventor(s): John Jewett
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Industrial & Manufacturing > Construction, Technology Classifications > Healthcare Portfolios > Wound Healing, Technology Classifications > Materials > Composites
|
|
Water-soluble Triazabutadienes that Release Diazonium Species upon Physiologically Relevant Protonation
This technology is a class of water-soluble triazabutadienes that deposit desired molecular diazonium salt cargo in a pH sensitive and reactive manner. The triazabutadiene is stable at higher pH values, allowing the decomposition to be controlled.
Background:
Certain viruses and pathogens, such as the dengue virus (DENV), have pH sensitive pathways...
Published: 3/12/2024
|
Inventor(s): John Jewett, Flora Kimani
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
|
|
Enzymatically Released Aryl Diazonium Ions
This invention is the discovery of triazebutadienes that rapidly release aryl diazonium ions at neutral pH with a half-life of approximately one minute.
Background:
In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics...
Published: 6/20/2024
|
Inventor(s): John Jewett, Lindsay Guzman, Bereketab Mehari, Jie He
Keywords(s):
Category(s): Technology Classifications > Life Sciences
|
