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Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling...
Published: 10/17/2024
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Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge, Indraneel Ghosh, Danielle Johnson, Abigail Shepard
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
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Triazabutadienes as Cleavable Protein Linkers
This technology describes water-soluble triazabutadienes as cleavable cross linkers. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling delivery of the cross-linked molecule.
Background:
Cross linking is becoming a valuable practice in chemistry, including for life science applications, with...
Published: 6/20/2024
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Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani, Brandon Cornali
Keywords(s):
Category(s): Technology Classifications > Materials > Polymers
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Enzymatically Released Aryl Diazonium Ions
This invention is the discovery of triazebutadienes that rapidly release aryl diazonium ions at neutral pH with a half-life of approximately one minute.
Background:
In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics...
Published: 6/20/2024
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Inventor(s): John Jewett, Lindsay Guzman, Bereketab Mehari, Jie He
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Releasable Triazabutadienes
This invention is a chemical means of protecting triazylbutadienes from degradation in acidic conditions. When exposed to a predetermined specific enzyme, the system can release triazylbutadiene. Triazylbutadienes can then go on to release aryl diazonium. This aryl species can be apart of various coupling reactions. This invention has the potential...
Published: 3/12/2024
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Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani
Keywords(s):
Category(s): Technology Classifications > Sensors & Controls, Technology Classifications > Sensors & Controls > Chemical & Gas, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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