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pH Releasable Linkers for Drug Delivery, Imaging, or Diagnostics
This technology describes water-soluble triazabutadienes as cross-linkers to and protecting groups for small-molecule therapeutics or fluorescent moities. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling targeted delivery of the cross-linked molecule.
Background:
Cross linking is becoming...
Published: 3/12/2024
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Inventor(s): John Jewett, Flora Kimani
Keywords(s): diagnostic tool
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
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Triazabutadienes as Cleavable Protein Linkers
This technology describes water-soluble triazabutadienes as cleavable cross linkers. Upon changes in chemical conditions, triazabutadienes release a highly reactive diazonium species, enabling delivery of the cross-linked molecule.
Background:
Cross linking is becoming a valuable practice in chemistry, including for life science applications, with...
Published: 3/12/2024
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Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani, Brandon Cornali
Keywords(s):
Category(s): Technology Classifications > Materials > Polymers
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Water-soluble Triazabutadienes that Release Diazonium Species upon Physiologically Relevant Protonation
This technology is a class of water-soluble triazabutadienes that deposit desired molecular diazonium salt cargo in a pH sensitive and reactive manner. The triazabutadiene is stable at higher pH values, allowing the decomposition to be controlled.
Background:
Certain viruses and pathogens, such as the dengue virus (DENV), have pH sensitive pathways...
Published: 3/12/2024
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Inventor(s): John Jewett, Flora Kimani
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery
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Releasable Triazabutadienes
This invention is a chemical means of protecting triazylbutadienes from degradation in acidic conditions. When exposed to a predetermined specific enzyme, the system can release triazylbutadiene. Triazylbutadienes can then go on to release aryl diazonium. This aryl species can be apart of various coupling reactions. This invention has the potential...
Published: 3/12/2024
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Inventor(s): John Jewett, Lindsay Guzman, Flora Kimani
Keywords(s):
Category(s): Technology Classifications > Sensors & Controls, Technology Classifications > Sensors & Controls > Chemical & Gas, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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