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A Method for Label-Free, Non-Invasive Acquisition and Mapping of -Omics Data
This technology describes a novel process to generate -omics data such as genomics, proteomics, and more through optical imaging. The invention is intended to implement spatial imaging techniques to identify optical imaging markers that can be predictors of -omics. This technology has potential for usage in a variety of fields including in vivo or ex...
Published: 4/24/2024
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Inventor(s): Travis Sawyer, Suzann Duan, Thomas Graham Knapp
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Identification of Inhibitors of Trogocytosis to Treat Cancer
This innovation is the identification and isolation of small molecules to inhibit trogocytosis to prevent or slow cancer cell tumor growth. Researchers plan to develop cell lines transduced with lentivirus vectors that can be cocultured and the process of trogocytosis will result in cell fusion that will generate a luminescent signal. Selected small...
Published: 4/4/2024
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Inventor(s): Alfred Bothwell, Haley Marcarian, Anutr Sivakoses
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers
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Metabolic Screening Methods for Endometrial Cancer
Researchers at the University of Arizona employed cervicovaginal lavage sampling and a global untargeted metabolomic approach to identify potential biomarkers for endometrial cancer. The study's novel approach involved linking cervicovaginal metabolite levels to crucial tumor characteristics such as size, histological grade, and myometrial invasion,...
Published: 3/1/2024
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Methods for Guiding Treatments of Vulvovaginal Symptoms and Female Sexual Dysfunction
Multi-omics analysis of cervicovaginal samples has led to the identification of a specific immune mediators, metabolites, and bacteria that are associated with vulvovaginal and sexual health symptoms. These biomarkers hold the potential to be utilized in a non-invasive test that guides the treatment of vulvovaginal symptoms and female sexual dysfunction...
Published: 1/16/2024
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Therapeutics
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Leukocyte Gene Expression Predicts Human Temporal Lobe Epilepsy Seizure Frequency
The leukocyte gene biomarkers presented here identify totally new and different genes whose expression predict temporal lobe epilepsy (TLE) seizure frequency. This seizure frequency prediction is a manifestation of the underlying pathophysiology of TLE disease states which have, heretofore, not been identified to have a dichotomized genetic basis. Targeting...
Published: 12/14/2023
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Inventor(s): Martin Weinand
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Biomarkers
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TROVE: A Translational Resource for Omics-Based Validation of Expression Datasets
Translational Resource for Omics-Based Validation of Expression (TROVE) is a solution-oriented query-able disease database that integrates various -omic data from animals and humans, reflective of the One Health paradigm. The innovation is focused on dataset integration and identification, to immediately provide targeted solutions for identified infection/immunity...
Published: 7/24/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Bryan Roxas
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Vaccines
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Method and System for Passive and Active Agent Delivery for Biomarker and Treatment Means
Plant-based extracellular vesicles have features leading to low immunogenicity with innate bioactive agents for targeting and/or treating specific biological effects. They can also be used as carriers with cargo drug from natural or synthetic products with higher bioavailability. The variety of plant categories also provide broad resources for lower...
Published: 11/16/2023
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Inventor(s): Frederic Zenhausern, Jerome Lacombe, Ashlee Harris, Zhu Zhao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Drug Delivery
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Diagnostic for Non-Invasive Screening and Early Detection of Adenomyosis
This technology is a non-invasive diagnostic for the screening and detection of adenomyosis. This could be used for women who are suffering with symptoms of chronic pelvic pain and adenomyosis for diagnosis without an invasive hysterectomy. In preliminary studies, there have been high acceptance of a particular sampling, that can provide information...
Published: 2/16/2024
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Women's Health
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Diagnostic for Screening and/or Predicting Women "at risk" for the Development and Progression Endometrial Cancer
This invention describes a novel method to use metabolic markers in samples obtained from cervicovaginal lavage (CVL) and machine-learning algorithms to detect patients “at risk” for endometrial cancer (EMC).
Background:
Endometrial cancer (EMC) is the most common gynecological cancer. The American Cancer Society estimates that in 2021...
Published: 11/16/2023
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Women's Health
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Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
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Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
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