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Leukocyte Gene Expression Predicts Human Temporal Lobe Epilepsy Seizure Frequency

The leukocyte gene biomarkers presented here identify totally new and different genes whose expression predict temporal lobe epilepsy (TLE) seizure frequency. This seizure frequency prediction is a manifestation of the underlying pathophysiology of TLE disease states which have, heretofore, not been identified to have a dichotomized genetic basis. Targeting...

Published: 12/14/2023 | Inventor(s): Martin Weinand

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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Biomarkers

Leukocyte RNA Expression: A Novel Neurosurgical Genomics Technique for Predicting Seizure-Free Outcome following Stereotactic Laser Amygdalohippocampotomy

This technology provides a novel set of gene-based biomarkers to predict seizure free results in Stereotactic Laser Amygdalohippocampotomy (SLAH) for epileptic patients. These biomarkers are based on leukocyte RNA expression so the prognosis can be easily done by a blood draw instead of a brain biopsy. Background: Drug resistant epilepsy patients...

Published: 4/3/2023 | Inventor(s): Martin Weinand, Ryan Sprissler, Michael Hammer

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Biomarkers