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Identification of Inhibitors of Trogocytosis to Treat Cancer
This innovation is the identification and isolation of small molecules to inhibit trogocytosis to prevent or slow cancer cell tumor growth. Researchers plan to develop cell lines transduced with lentivirus vectors that can be cocultured and the process of trogocytosis will result in cell fusion that will generate a luminescent signal. Selected small...
Published: 4/4/2024
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Inventor(s): Alfred Bothwell, Haley Marcarian, Anutr Sivakoses
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers
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Transplantable Murine Cutaneous Squamous Cell Carcinoma Cell Lines
This innovation involves the creation of novel cell lines for studying cutaneous squamous cell carcinoma (cSCC) in mice. These cell lines, derived from UV-induced cSCC tumors in BALB/c mice, recapitulate the mutational signature and driver mutations found in human cSCC. Developing the cell lines from an inbred mouse strain allows for studies involving...
Published: 4/11/2024
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Inventor(s): Karen Hastings, Anngela Adams, Anne Macy
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Healthcare Portfolios > Oncology
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Pharmacological Inhibition of PD-L1 as an Antagonist of Skin Damage and Cancer in response to Acute and Chronic Solar UV Exposure and Other Environmental Toxicants
This innovation is the development of a pharmacological inhibitor of PD-L1 to prevent or reduce the negative impact of acute and chronic solar UV exposure and environmental toxicants on the skin. PD-L1 is a molecule involved in immune regulation and can be upregulated in response to UV radiation and environmental toxins. However, overexpression of PD-L1...
Published: 3/6/2024
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Inventor(s): Sally Dickinson, Georg Wondrak, Clara Curiel
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Methods and System for Closed-Loop Ultrasound and Photoacoustic Imaging
This technology is a novel closed-loop volumetric ultrasound and photoacoustic imaging and spectroscopy method that is operator-independent. The technology can be integrated with existing hardware systems, and it offers the flexibility to scale from standard clinical ultrasound to high-frequency preclinical imaging for visualizing structures at different...
Published: 1/16/2024
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Inventor(s): Russell Witte, Eric Reichel, Clara Curiel, Christopher Salinas, Delaney Stratton
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Bioorthogonal Activation of PROTAC Prodrugs
Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and...
Published: 1/16/2024
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Inventor(s): Wei Wang, Mengyang Chang, Giri Gnawali
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Redox-Activated Pro-Chelators
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Oncology
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Herbostroiodine: An Herbal-Based Radioprotective Drug Against I-131 and Sr90 Radioactive Elements with Dual Actions
Herbostroiodine is an innovative herbal extended release radioprotective drug formulated with a multilayer noisome carrier. Its composition includes chloroform extract of Mint, Kaempferol-Iodine-127 (non-radioactive iodine conjugated with Kaempferol), and Fulvic acid. The use of noisome as a carrier enhances oral bioavailability and allows for the simultaneous...
Published: 1/3/2024
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Inventor(s): Sara Sheikhlary
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences > Therapeutics
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Iron Targeting to Halt Proliferation in Malignant Cells
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron and thereby interfere in cancer cell proliferation or other iron dysregulation. The redox potential of various analogues within this class of compounds can be tuned for targeting of cancer cells. Following cellular uptake, the tetrazolium...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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A Recombinant Protein to Restore the Anti-Cancer Activity of Immune Cells
This invention is a recombinant protein that is designed to restore the activity of immune cells that have been exhausted in patients with cancer. This invention focuses specifically on the restoration of the anti-cancer activity of immune cells, in particular natural killer (NK) cells.
Background:
Immune cell-based therapies are a widely utilized...
Published: 11/16/2023
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Inventor(s): Youngwook Won, Seungmin Han, David Bull
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Targeted Cancerous Cell Specific Suicide Gene Therapy
This invention describes a novel cancer therapy method that induces cell death mechanisms in only cancer cells.
Background:
The current standard of care for cancer therapy in many cases is chemotherapy. Chemotherapy, like many cancer treatments, causes significant amounts of healthy cells to die in addition to the cancer cells, leading to the well-known...
Published: 4/3/2023
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Inventor(s): Ravi Goyal
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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