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Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment
This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested.
Background:
It is estimated...
Published: 7/8/2024
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Inventor(s): Elisa Tomat, Iva Habensus, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health
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Redox-Activated Pro-Chelators
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Oncology
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Iron Targeting to Halt Proliferation in Malignant Cells
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron and thereby interfere in cancer cell proliferation or other iron dysregulation. The redox potential of various analogues within this class of compounds can be tuned for targeting of cancer cells. Following cellular uptake, the tetrazolium...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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