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Redox-Activated Pro-Chelators
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Oncology
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Disulfide-Masked Prochelators for Intracellular Metal Sequestration
A novel pro-drug compound is activated into an iron chelating agent within the reducing environment of the cytoplasm of cancer cells. This invention provides enhanced selectivity to target cancer cells as compared to previous iron chelation approaches. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
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Glycoconjugates of Antiproliferative Iron Pro-Chelators Targeting Cancer Cell Metabolism
This technology provides novel glycoconjugates of antiproliferative iron pro-chelators that target the altered metabolism of cancer cells.
The key to the success of chelation therapy in cancer treatment is the ability to target iron ions in malignant cells without affecting iron levels in the bloodstream and in normal tissues. Lacking such selectivity,...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators
This invention is a novel strategy to create iron chelators by utilizing a disulfide redox switch to connect carbohydrate moieties to a thiosemicarbazone iron-binding unit. This increases expression of glucose transporters in colorectal cancer cells and greater toxicity to cancer cells.
Background:
An increased amount of iron in colorectal cancer...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Oncology
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