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Redox-Activated Pro-Chelators
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Oncology
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Iron Targeting to Halt Proliferation in Malignant Cells
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron and thereby interfere in cancer cell proliferation or other iron dysregulation. The redox potential of various analogues within this class of compounds can be tuned for targeting of cancer cells. Following cellular uptake, the tetrazolium...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Iron-targeting to stop cancer growth in malignant cells
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Following cellular uptake, the tetrazolium...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Zoufeng Xu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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New Libraries of Disulfide Prochelators and Application of Treating Metal Ion Disregulation
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate...
Published: 3/12/2024
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Inventor(s): Elisa Tomat
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Ophthalmology, Technology Classifications > Life Sciences > Therapeutics
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Intracellular Reduction/Activation of a Disulfide Switch in Thiosemicarbazone Iron Chelators
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, taking advantage of the reducing...
Published: 3/12/2024
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Inventor(s): Elisa Tomat
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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Disulfide-Masked Prochelators for Intracellular Metal Sequestration
A novel pro-drug compound is activated into an iron chelating agent within the reducing environment of the cytoplasm of cancer cells. This invention provides enhanced selectivity to target cancer cells as compared to previous iron chelation approaches. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
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Glycoconjugates of Antiproliferative Iron Pro-Chelators Targeting Cancer Cell Metabolism
This technology provides novel glycoconjugates of antiproliferative iron pro-chelators that target the altered metabolism of cancer cells.
The key to the success of chelation therapy in cancer treatment is the ability to target iron ions in malignant cells without affecting iron levels in the bloodstream and in normal tissues. Lacking such selectivity,...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators
This invention is a novel strategy to create iron chelators by utilizing a disulfide redox switch to connect carbohydrate moieties to a thiosemicarbazone iron-binding unit. This increases expression of glucose transporters in colorectal cancer cells and greater toxicity to cancer cells.
Background:
An increased amount of iron in colorectal cancer...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Eman Akam
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Oncology
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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Redox-Directed Chelators Targeting Intracellular Metal Ions
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, taking advantage of the reducing...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Tsuhen Chang
Keywords(s): cancer
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
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