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Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors.
Background:
The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Bioorthogonal Activation of PROTAC Prodrugs
Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and...
Published: 1/16/2024
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Inventor(s): Wei Wang, Mengyang Chang, Giri Gnawali
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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A Pashto-English Dictionary
This technology is a multi-use dictionary that contains Pashto entries with corresponding English words, allowing individuals to learn either Pashto or English.
Background:
Current versions of online Pashto dictionaries have varying amounts of Pashto entries with English translations, many of which have no verification of their learning materials,...
Published: 4/3/2023
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Inventor(s): Yan Han, Atifa Rawan
Keywords(s):
Category(s): Technology Classifications > Creative Works, Technology Classifications > Software & Information Technology > Web & Internet
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