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Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors.
Background:
The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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