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Transplantable Murine Cutaneous Squamous Cell Carcinoma Cell Lines
This innovation involves the creation of novel cell lines for studying cutaneous squamous cell carcinoma (cSCC) in mice. These cell lines, derived from UV-induced cSCC tumors in BALB/c mice, recapitulate the mutational signature and driver mutations found in human cSCC. Developing the cell lines from an inbred mouse strain allows for studies involving...
Published: 4/11/2024
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Inventor(s): Karen Hastings, Anngela Adams, Anne Macy
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Healthcare Portfolios > Oncology
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KM Cells - A Metastatic Cell Line and Method of Producing
In this study, researchers at the University of Arizona investigated an early cancer invasion event using a unique in vivo model. Muscle invasion was tested by the ability of prostate cancer cells to colonize the inferior surface of the respiratory diaphragm of male NGS mice, invade into and through to the superior surface. They isolated and compared...
Published: 5/2/2023
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Inventor(s): Kendra Marr, Anne Cress
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences
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Human Colon Polyp Derived Organoid
This innovation is a patient-derived organoid that is used as a screening platform to study both tissues patterning and the kinase pathway dynamics in single cells across many conditions. Through this technology one is able to evaluate the patterning and homeostasis of the cells and tell when they are out of alignment. Through the use of this technology...
Published: 10/4/2023
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Inventor(s): Kelvin Pond, Curtis Thorne, Andrew Paek
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Research Tools > Cell Lines
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Design and Application of Novel Ligand-Induced Split-Protein Systems
This invention is a split protein system that functions as a biotechnological chemically-induced dimerization (CID) tool. These CID systems are useful for biological research to control numerous outputs in living organisms such as inducing the activation of a specific protein, protein localization, and inducing transcription. This novel CID system...
Published: 3/12/2024
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Inventor(s): Indraneel Ghosh, Samuel Sugerman, Brittany Stankavich
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays
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GL261-luc2 Model
GL261 (mouse glioma 261) is an in vivo model system used to study glioblastoma multiforme (GBM). This technology is the GL261 cell line stably transfected with the luc2 gene (GL261-luc2) for the monitoring of intracranial mouse tumors. GL261-luc2 is a brighter version than the original GL261-luc line.
Relevant Paper:
Abdelwahab MG, Sankar T, Preul...
Published: 11/16/2023
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Inventor(s): Adrienne Scheck
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines
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Human Delta Opioid Receptor cDNA
A cDNA clone containing the entire open reading fame of a human delta opioid receptor.
Background:
The delta opioid receptor is an important target for drug development. Testing drugs for activity at human delta opioid receptors requires access to appropriate tissue, which is generally unavailable. This technology enables bioactivity studies at this...
Published: 4/3/2023
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Inventor(s): Richard Knapp, Ewa Malatynska, William Roeske, Henry Yamamura
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Life Sciences > Diagnostics
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HEK Cell Line Expressing Human EP4 Prostanoid Receptors
Nucleotides 360-1890 from the human EP4 prostanoid receptor were PCR amplified from the small intestine, and digested with SspI and ScaI. The product was cloned into the plasmid ECoRV. This plasmid was digested with HindIII and XhoI, and the product was cloned into pCEP4, and transfected into 293-EBNA cells. Transformed lines were selected with hygromycin....
Published: 4/3/2023
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Inventor(s): John Regan
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines
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A Vector System for Direct Cloning of Eukaryotic Gene Constructs
Yeast-Agrobacterium-Bacteria (YAB) is a combination of two technologies: yeast recombination capabilities and Agrobacterium tumefaciens-mediated transformation (ATMT). Generation of ATMT constructs usually requires PCR-amplification of DNA fragments and multiple cloning steps into binary Agrobacterium vectors. YAB is a plasmid vector that can be used...
Published: 2/7/2024
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Inventor(s): Maria Alejandra Mandel
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines
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HEK Cell Line Expressing Human FP Prostanoid Receptors
University of Arizona researchers have created human embryonic kidney cells expressing the human FP prostanoid receptors. These G-coupled receptors are widely found in smooth muscle such as the gastrointestinal tract and in bronchial tissue. As such, the new cell lines are expected to be a useful research tool for investigating receptor activity: they...
Published: 4/3/2023
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Inventor(s): John Regan
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines
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