|
Discovery of Novel Wnt Inhibitors and Uses Thereof
Canonical WNT (Wingless/integrase 1) signaling is an important developmental pathway that has attracted increased attention for anti-cancer drug discovery. Researchers at the University of Arizona are investigating utility for the compounds herein for the treatment of colorectal cancer as well as potential disease modifying agents for the treatment...
Published: 11/14/2024
|
Inventor(s): Christopher Hulme, Sammantha Rokey, Yeng Jeng Shaw, Curtis Thorne, Timothy Chavez, Carly Cabel, Nathan Bedard, Sourav Banerjee
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios
|
|
Human Colon Polyp Derived Organoid
This innovation is a patient-derived organoid that is used as a screening platform to study both tissues patterning and the kinase pathway dynamics in single cells across many conditions. Through this technology one is able to evaluate the patterning and homeostasis of the cells and tell when they are out of alignment. Through the use of this technology...
Published: 10/4/2023
|
Inventor(s): Kelvin Pond, Curtis Thorne, Andrew Paek
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Research Tools > Cell Lines
|
|
Small Molecule DYRK/CLK Inhibitors and Uses Thereof
This invention is a new composition of matter spanning a 6,6-fused chemotype. The 6,6-analogs display strong inhibitory activity across protein kinases such as the DYRK family, including DYRK1A, DYRK2, and DYRK3, along with inhibiting CLK. The dual DYRK/CLK inhibitors have displayed activity in 3-D organoid models of glioblastoma. It is subsequently...
Published: 11/14/2024
|
Inventor(s): Christopher Hulme, Alessandra Fistrovich, Yeng Jeng Shaw, Sourav Banerjee, Curtis Thorne, Nathan Bedard, Carly Cabel
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
|
|
High Dimensional Structure-Activity Relationship Approach in Cell-Based Screening for Drug Effects in Intestine
This technology is a high throughput assay utilizing 3D cell culture and multiplex antibody staining techniques to study features of the intestine under various conditions. This technology can be utilized to screen drugs for intestine-related diseases and/or examine drugs for gut toxicity. A complimentary software is then used to measure and analyze...
Published: 4/14/2023
|
Inventor(s): Curtis Thorne, Elaheh Alizadeh, Kelvin Pond
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
|
|
Rapid Image-Based Screening for Bioactive Compounds that Block SARS-CoV-2 Replication Cycle
This invention is a rapid image-based drug screening software platform for bioactive compounds that can block SARS-CoV-2 replication cycles. The invention utilizes a custom image processing algorithm that utilizes microscopy images to develop drug response profiles to identify lead compounds. This technology can also be used to neutralize antibodies,...
Published: 4/14/2023
|
Inventor(s): Curtis Thorne, Elaheh Alizadeh, Koenraad Van Doorslaer, Samuel Campos, Carly Cabel, Shuaizhi Li
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Software & Information Technology > Health IT
|
