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Design and Application of Novel Ligand-Induced Split-Protein Systems
This invention is a split protein system that functions as a biotechnological chemically-induced dimerization (CID) tool. These CID systems are useful for biological research to control numerous outputs in living organisms such as inducing the activation of a specific protein, protein localization, and inducing transcription. This novel CID system can...
Published: 6/6/2024
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Inventor(s): Indraneel Ghosh, Samuel Sugerman, Brittany Stankavich
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays
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Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling...
Published: 10/17/2024
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Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge, Indraneel Ghosh, Danielle Johnson, Abigail Shepard
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
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Design and Application of New Split-Luciferase Enzymes
UArizona researchers have developed a new split-firefly luciferase enzyme method for measuring protein-protein interactions for assays or sensors. This new method may, when combined with previous split luciferase methods, enable assays for two different protein interactions simultaneously, as well as provide a means for additional biophysical characterization....
Published: 3/12/2024
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Inventor(s): Indraneel Ghosh, Matthew Bienick, Sean Campbell, Carl Buchholz
Keywords(s):
Category(s): Technology Classifications > Research Tools > Protein, Technology Classifications > Life Sciences
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