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Method and System for Passive and Active Agent Delivery for Biomarker and Treatment Means
Plant-based extracellular vesicles have features leading to low immunogenicity with innate bioactive agents for targeting and/or treating specific biological effects. They can also be used as carriers with cargo drug from natural or synthetic products with higher bioavailability. The variety of plant categories also provide broad resources for lower...
Published: 11/16/2023
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Inventor(s): Frederic Zenhausern, Jerome Lacombe, Ashlee Harris, Zhu Zhao
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Drug Delivery
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Apparatus for Active Tissue Scaffold Stretching in Cell Culture Conditions
This invention is a means to apply controlled dynamic forces on a macroscale tissue scaffold along a period of cell culture conditions that can range from minutes to weeks. This apparatus uses a mechanically compliant substrate, which can be made from various materials, that supports the attached tissue scaffold. The apparatus also contains a holder...
Published: 11/16/2023
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Inventor(s): Ashlee Harris, Jerome Lacombe, Baiju Thomas, Matthew Barrett, Frederic Zenhausern, Alan Nordquist
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Simulators and Modeling Tools
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Methods and Apparatus Suitable for Interrogating Biological Systems: Tumor-on-Chip
This technology is a tumor-on-chip that can be utilized in research and development of drugs. The tumor-on-chip is a 3D structure that consists of multiple cellular components found within a tumor micro-environment (TME). The TME is the environment around a tumor that consists of both cellular and non-cellular components. The TME plays a large role...
Published: 11/16/2023
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Inventor(s): Jerome Lacombe, Matthew Barrett, Frederic Zenhausern
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools
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Methods For Building A Self-Contained Responsive Biological System
This technology is a new organ modeling system that utilizes plant leaves to study cancer mechanism and drug interactions. It focuses on the optimized scaffolding of decellularized plant tissues seeded with mammalian cells. The model is ideal for producing a 3D vascularized biological system that can be dynamically controlled through changes in perfusion...
Published: 11/16/2023
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Inventor(s): Jerome Lacombe, Ashlee Harris, Ryan Zenhausern, Frederic Zenhausern
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Research Tools
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