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Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazene Reagents

Triazenes and methods of producing diazonium species from said triazenes using ultraviolet (UV) light, which provide a fast, easy, stable, scalable, and selectively-triggerable means of modifying aromatic nucleophiles, including those on protein surfaces. The invention includes triazenes for use as bioconjugates, e.g., for use in protein modification,...

Published: 3/12/2024 | Inventor(s): Garrett Davis, John Jewett

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Category(s): Technology Classifications > Research Tools > Reagents

Shelf-Stable Reagent for Bioconjugation and Protein Labeling

This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...

Published: 3/12/2024 | Inventor(s): John Jewett, Garrett Davis, Holly Sofka

Keywords(s):

Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics