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Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazine Reagents

The invention includes triazines for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc. Application of UV light at neutral pH releases diazonium species, which can be used in a wide variety of applications, including protein...

Published: 8/26/2024 | Inventor(s): Garrett Davis, John Jewett

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Category(s): Technology Classifications > Research Tools > Reagents

Shelf-Stable Reagent for Bioconjugation and Protein Labeling

This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...

Published: 6/20/2024 | Inventor(s): John Jewett, Garrett Davis, Holly Sofka

Keywords(s):

Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics