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Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 3/12/2024
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Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
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Transcription Inhibition Targeted Therapy, Including for Ewing's Sarcoma
This technology features the use of a transcription inhibitor combined with a DNA damaging agent to induce tumor cell death for tumors that have FET-fused oncogenes, such as cells and tumors associated with Ewing's sarcoma and fibromyxoid Iposarcoma. This combination therapy targets members of the FET protein family that are translocated to form...
Published: 3/12/2024
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Inventor(s): Matthew Rollins, Jacob Schwartz
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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FET-Protein Fusions as a Marker of Sensitivity to Transcription Inhibitors and Cyclin-Dependent Kinase Inhibitors
This technology seeks to take advantage of members of the FET protein family that are translocated to form fusion oncogenes. This presents an opportunity to use FET-protein fusions as a means of identifying and treating cancer. Combined treatment of Ewing's sarcoma with a transcription inhibitor, such as flavopiridol, increases cellular sensitivity...
Published: 3/12/2024
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Inventor(s): Matthew Rollins, Jacob Schwartz, Nasiha Ahmed
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Detection of Protein: Nucleic Acid Interactions by Differential Chemical Conjugation
This invention features methods, systems, and compositions for detecting interactions between biomolecules. The methods or systems of the present invention may feature comparing the amount of labeling or modification of a molecule in a test sample with the amount of labeling or modification of the molecule in a control sample. For example, the method...
Published: 3/12/2024
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Inventor(s): Jacob Schwartz, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics
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Quantitative Detection of Protein Misfolding or Aggregation by Chemical Labeling
This invention describes methods and systems for detecting, comparing, or evaluating proteins in a folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 6/20/2024
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Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour, Mehrdad Shadmehr
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Medical Devices > Diagnostic
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Detection of Folding State of a Macromolecules by Chemical Conjugation
Methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of the present invention may be used for a variety of applications...
Published: 3/12/2024
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Inventor(s): Jacob Schwartz, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Biomarkers
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