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A Method for Characterizing Adeno-Associated Virus Capsids with Thermal Unfolding and Mass Spectrometry
This invention describes modulating the temperature of the solution in an electrospray needle prior to charge-detection mass spectrometry (CD/MS) to enable discrimination between the individual stabilities of multiple forms of viral particles that may be present in an AAV preparation. This increased discrimination provides the operator with a unique...
Published: 3/12/2024
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Inventor(s): Michael Marty, Marius Kostelic
Keywords(s):
Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Research Tools > Reagents, Technology Classifications > Materials > Biomaterials
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Novel Mechanism Anti-Fungal with High Specificity
University of Arizona researchers have discovered a novel approach for treating fungal or yeast infections using a previously unstudied GPCR-like protein, which is integral to the regulation of cell growth in yeast cells. This protein and metabolic pathway is absent in higher-order animals, which provides a novel pathway for drugs to stop the growth...
Published: 3/12/2024
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Inventor(s): Andrew Capaldi, Ryan Wallace, Eric Lu
Keywords(s):
Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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An Essential and Unique Virulence Molecule in Pathogenic Escherichia Coli
This invention relates to a secreted protein that plays a critical role in mediating virulence of pathogenic E. coli. Utilizing a functionally equivalent mouse pathogen, in both in vitro and in vivo virulence studies, the investigators demonstrated that the premature death of intestinal epithelial cells could be prevented.
Background:
There are...
Published: 4/3/2023
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Inventor(s): Virinchipuram Viswanathan, Gayatri Vedantam
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines
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Domain of a Protein Antigen from Coccidioides immitis which Induces Protection Against Coccidoidal Infection
Researchers at the University of Arizona have determined the precise conformation required to confer resistance to C. immitis or Valley Fever, which is endemic to Southwestern United States, Mexico, and other Latin American countries. They have identified a subunit of C. immitis antigen that would both prevent coccidioidomycosis and optimize the vaccine...
Published: 4/3/2023
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Inventor(s): John Galgiani, Kris Orsborn, Tao Peng, Lisa Shubitz
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Veterinary Medicine, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Life Sciences > Therapeutics
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