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Hadamard Transform-Charge Detection-Mass Spectrometry
This technology uses a multiplexing approach to online size exclusion chromatography (SEC) coupled with Orbitrap CD-MS. A microcontroller is used to deliver pulsed injections from a large sample loop onto a SEC for online CD-MS analysis. The method produces a series of peaks spaced according to the pseudo-random injection sequence, which are demultiplexed...
Published: 3/29/2024
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Inventor(s): Michael Marty, James Sanders
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Engineering & Physical Sciences, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry
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The UniDec Processing Pipeline (UPP)
This mass spectrometry analysis software and method extends the UniDec Bayesian deconvolution algorithm for application to rapid analysis of biotherapeutics, including determining the drug-to-antibody ratio for antibody-drug conjugates and calculating the correct pairing of bispecific antibodies.
Background:
Mass spectrometry (MS) and intact mass...
Published: 3/12/2024
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Inventor(s): Michael Marty
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Open Source
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A Method for Characterizing Adeno-Associated Virus Capsids with Thermal Unfolding and Mass Spectrometry
This invention describes modulating the temperature of the solution in an electrospray needle prior to charge-detection mass spectrometry (CD/MS) to enable discrimination between the individual stabilities of multiple forms of viral particles that may be present in an AAV preparation. This increased discrimination provides the operator with a unique...
Published: 3/12/2024
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Inventor(s): Michael Marty, Marius Kostelic
Keywords(s):
Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Research Tools > Reagents, Technology Classifications > Materials > Biomaterials
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Surface-Modified Electrospray Needles for Mass Spectrometry
With this invention, electrospray needles used in mass spectrometry are coated to prevent sticking and clogging of analytes, resulting in improved mass detection sensitivity and consistency of analysis. The coating comprises an organic material covalently bonded to an interior surface of the electrospray needle. The coating is electrically non-conductive...
Published: 3/12/2024
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Inventor(s): Michael Marty, Craig Aspinwall, Marius Kostelic, Chih-Chieh Hsieh
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Coatings
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Deconvolution of Charge Detection-Mass Spectrometry Data
This mass spectrometry analysis software and method extends the UniDec Bayesian deconvolution algorithm for application to two-dimensional charge detection-mass data. A 2D plot of m/z versus charge is created from raw data. Smoothing and background subtraction may be used, and deconvolution is applied to remove uncertainty in the charge and the m/z...
Published: 3/12/2024
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Inventor(s): Michael Marty, Marius Kostelic
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry
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Automated Lipid Exchange-Mass Spectrometry System
This invention is an automated label-free method to measure the affinity of membrane proteins for lipids by using conventional small molecule mass spectrometry (MS) to monitor lipid exchange between lipoprotein nanoparticles called nanodiscs. We call this method lipid exchange-mass spectrometry (LX-MS). The concept is that if a membrane protein binds...
Published: 3/12/2024
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Inventor(s): Michael Marty, James Keener, Guozhi Zhang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Protein
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