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A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker.
Background:
Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 11/16/2023
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Inventor(s): Rajesh Khanna, Jun Wang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
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Blocking NRP-1 for the Treatment of Pain, Cancer and Prevention of Viral Entry
This invention discloses a novel method for the treatment of pain and cancer as well as the prevention of viral entry, most notably SARS-CoV-2. The inventors have identified a number of promising lead compounds which bind to and interrupt neuropilin 1 (NRP-1) signaling. This is an important first step in the development of small molecule inhibitors...
Published: 4/3/2023
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Inventor(s): Rajesh Khanna, Aubin Moutal, Samantha Perez-Miller
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules
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T-Type Calcium Channel Enhancer for TAF1 Associated Neurological Defects
This invention relates to TAF1-ID animal model and new use for SAK3 which was first developed as a T-type voltage gated Ca2+ channel enhancer for treating TAF1 intellectually disability (TAF1 ID) syndrome, an x-linked disorder caused by loss-of-function mutations in the TAF1 gene.
Background:
TATA-box binding protein associated factor 1 (TAF1) plays...
Published: 11/16/2023
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Inventor(s): Mark Nelson, Rajesh Khanna, Janakiraman Udaiyappan, Dhanalakshmi Shankara Raman
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
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Discovery of T-Type Calcium Channel Antagonist from Multicomponent Reactions and their Application in Paclitaxel-Induced Peripheral Neuropathy
This invention uses innovative selective T-type antagonists in order to ease pain involved with chemotherapy-induced peripheral neuropathy (CIPN).
Background:
Chemotherapy remains a frontline treatment for many forms of cancer, however, chemotherapy agents commonly cause severe side effects such as CIPN. While opioids have been used to manage CIPN,...
Published: 11/16/2023
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Inventor(s): Jun Wang, Rajesh Khanna
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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