Search Results - nathan+bedard

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Discovery of Novel Wnt Inhibitors and Uses Thereof
Canonical WNT (Wingless/integrase 1) signaling is an important developmental pathway that has attracted increased attention for anti-cancer drug discovery. Researchers at the University of Arizona are investigating utility for the compounds herein for the treatment of colorectal cancer as well as potential disease modifying agents for the treatment...
Published: 11/14/2024   |   Inventor(s): Christopher Hulme, Sammantha Rokey, Yeng Jeng Shaw, Curtis Thorne, Timothy Chavez, Carly Cabel, Nathan Bedard, Sourav Banerjee
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios
Small Molecule DYRK/CLK Inhibitors and Uses Thereof
This invention is a new composition of matter spanning a 6,6-fused chemotype. The 6,6-analogs display strong inhibitory activity across protein kinases such as the DYRK family, including DYRK1A, DYRK2, and DYRK3, along with inhibiting CLK. The dual DYRK/CLK inhibitors have displayed activity in 3-D organoid models of glioblastoma. It is subsequently...
Published: 11/14/2024   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Yeng Jeng Shaw, Sourav Banerjee, Curtis Thorne, Nathan Bedard, Carly Cabel
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
Tunable Fluorescent Indolizine Tetracycles
This technology is tunable fluorescent probes that are able to span the colors of the rainbow. The main benefit of this technology is that it can be prepared in only one or two steps; as opposed to the five to seven steps it would normally take. Not only is this technology quicker, but the cost of goods is also more reasonable and compares very favorably...
Published: 11/16/2023   |   Inventor(s): Christopher Hulme, Nathan Bedard, Andrew Sennett
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Reagents