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DNA E2E: End-to-End Programmable Microfluidic Platform (PMP) for DNA Data “Write-to-Store-to-Read” with Cold Storage of DNA Data in Synthetic Fossils and Metal-Organic Scaffolds using Supercritical Fluid (SCF) Processing

The inventors have combined an error-correcting information strategy for DNA with a supercritical fluid method for drying and storing DNA. The system features an apparatus suitable for end-to-end programmable DNA storage automation using a write-to-store-to-read data cycle via a programmable microfluidic platform (PMP). The system also features a method...

Published: 4/15/2024 | Inventor(s): Frederic Zenhausern, Devasier Bennet, Tuan Vo-Dinh, Supreya Atta

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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Materials > Biocompatible

Methods and Materials for Modulating Construct Wear Due to Cyclic Loading

Rethinking the structural organization of a polymer is a normally forgone solution for improving polymer flexibility. Here, the inventors have created four improved ways to manufacture polymers. The first is to create it at its mid-stress point, the second is to make the polymer with a shifting neutral axis, the third method uses polymers to provide...

Published: 11/16/2023 | Inventor(s): Marvin Slepian, Syed Hossainy

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Category(s): Technology Classifications, Technology Classifications > Materials > Biocompatible, Technology Classifications > Healthcare Portfolios, Technology Classifications > Medical Devices

3D Printed Epifluidics

University of Arizona researchers have developed a method to print wearable sweat collection devices to that enable 24/7 sweat collection over weeks without the use of adhesives. This technology provides an easily manufacturable method for producing these devices with accurate control over channel design and integration with electrical components, enabling...

Published: 2/1/2024 | Inventor(s): Philipp Gutruf, Tucker Stuart

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Category(s): Technology Classifications > Materials > Biocompatible, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Medical Devices > Diagnostic

Stereospecific Synthesis of Rhamnolipids and their Sugar Analogues from Sustainable Sources by Chemical and Chemoenzymatic Pathway

This technology is a method of synthesizing enantiomerically pure rhamnolipids without the need for a chromatographic separation, such synthesis using enzymatic processing. The method may be used to create compounds with multiple, specific chiral centers. Background: Rhamnolipids are a type of chemical notable particularly for their surfactant...

Published: 3/12/2024 | Inventor(s): Jeanne Pemberton, Tyler Roberts

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Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Biomaterials, Technology Classifications > Materials > Biocompatible

Sugar-Based Low Molecular Weight Hydrogels from Alkyl Glycolipids

University of Arizona researchers have created sugar-based low molecular weight hydrogels that spontaneously self-assemble through weak, noncovalent intermolecular interactions. These gels are thixotropic, biocompatible, and biodegradable. Despite being held together through non-covalent interactions, these hydrogels exhibit greater mechanical strength...

Published: 3/12/2024 | Inventor(s): Jeanne Pemberton, Laurel Kegel, Yu-Cheng Wang

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Nucleophilic Activation of Elemental Sulfur with Amines and Nucleophilic Heterocycles

This invention describes a process to utilize nucleophiles to activate elemental sulfur. Background: Existing catalytic methods involve heavy metal components and ultraviolet light. Alternative options also include using free-radicals to catalyze a polymerization reaction. The invention instead has the benefit of generating intermediates with unexplored...

Published: 3/12/2024 | Inventor(s): Dong-Chul Pyun, Richard Glass

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Category(s): Technology Classifications > Energy, Cleantech & Environmental > Fuel Cells, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Biomaterials, Technology Classifications > Materials > Polymers, Technology Classifications > Medical Devices > Diagnostic

Injectable Protein-Based Hydrogels with Ligand-Mediated Reinforcement for Long-Term In Vivo Applications

This technology is a protein-based hydrogel that uses cross-links to self-assemble after injection. The technology addresses the issue with in vivo use of hydrogels by merging the biocompatability of a protein hydrogel with a reinforced rupture force typically found in chemical hydrogels. An injectable hydrogel with these properties has immense potential...

Published: 2/1/2024 | Inventor(s): Minkyu Kim, David Knoff

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Category(s): Technology Classifications > Materials, Technology Classifications > Healthcare Portfolios > Wound Healing, Technology Classifications > Materials > Biocompatible

Reactive, Fluorescent Coumarin Dyes for Making Thermosets Visible under Ultraviolet Light

The invention describes a novel use for coumarin dyes to make thermosets visible under only certain conditions, which provides a means of identifying whether or not a reaction has occurred. In addition, this technology is capable of allowing the user to hide the use of an epoxy unless there is a need to see it. Background: Dyes are most often used...

Published: 2/1/2024 | Inventor(s): Douglas Loy, Peter Mcfadden

Keywords(s):

Category(s): Technology Classifications > Materials > Biocompatible

Fluorogenic Diazonium-Derived Fluorophores

This technology describes various diazonium salts that can react to produce a fluorescent azobenzene compound. Background: Current iterations of fluorescent diazonium salts utilize metal catalysts to produce a reaction. However, these metal catalysts can have harmful effects in a medical setting. This invention consists of a bioorthogonal approach...

Published: 3/12/2024 | Inventor(s): John Jewett, Bereketab Mehari, Mehrdad Shadmehr

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Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Medical Devices > Diagnostic

Novel Method for Synthesis of Indoles

This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner. Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents....

Published: 3/12/2024 | Inventor(s): Jon Njardarson, Edon Vitaku

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