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Novel Method for Synthesis of Indoles
This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner.
Background:
Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents....
Published: 3/12/2024
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Inventor(s): Jon Njardarson, Edon Vitaku
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Materials > Ceramics, Technology Classifications > Materials > Biocompatible, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Medical Devices > Therapeutic
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Meta-Selective Alkylation of Phenolic Substrates
The technology is a method of meta-selective alkylation which requires no heating and has short reaction times relative to existing processes. The process relies on dearomatization of phenolic rings, introduction of the functional group at the meta- position, and rearomatization of the phenol. The process requires no directing group.
Background:...
Published: 3/12/2024
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Inventor(s): Jon Njardarson, Edon Vitaku
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Processing
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Metal Free Scalable Synthesis of Fluorinated Indole and Benzofuran Structures
This technology is a novel one step method to generate fluorinated aryl groups for use in various other reactions.
Background:
There are few alternative existing methods to treat arrhythmia. Originally, there were a slew of powerful anti arrhythmic drugs on the market which had the potential to treat the cardiovascular condition. However, the majority...
Published: 3/12/2024
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Inventor(s): Jon Njardarson, Edon Vitaku, David Smith
Keywords(s):
Category(s): Technology Classifications > Materials > Processing
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