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Novel Small Molecule Compounds with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases

This invention comprises a series of novel small molecule compounds developed at the University of Arizona and their method of use for the treatment of locomotor dysfunction associated with Amyotrophic Lateral Sclerosis (ALS) and other diseases associated with proteinopathy of a transactive response (TAR) DNA binding protein, TDP-43. Testing in a previously...

Published: 3/12/2024 | Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics

Metal Free Scalable Synthesis of Fluorinated Indole and Benzofuran Structures

This technology is a novel one step method to generate fluorinated aryl groups for use in various other reactions. Background: There are few alternative existing methods to treat arrhythmia. Originally, there were a slew of powerful anti arrhythmic drugs on the market which had the potential to treat the cardiovascular condition. However, the majority...

Published: 3/12/2024 | Inventor(s): Jon Njardarson, Edon Vitaku, David Smith

Keywords(s):

Category(s): Technology Classifications > Materials > Processing