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Novel Small Molecule Compounds with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases
This invention comprises a series of novel small molecule compounds developed at the University of Arizona and their method of use for the treatment of locomotor dysfunction associated with Amyotrophic Lateral Sclerosis (ALS) and other diseases associated with proteinopathy of a transactive response (TAR) DNA binding protein, TDP-43. Testing in a previously...
Published: 10/15/2024
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Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
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Novel Small Molecules with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases
This invention is a series of novel small molecule compounds developed at the University of Arizona that may be used in the treatment of Amyotrophic Lateral Sclerosis (ALS), particularly in treating the locomotor dysfunction associated with the disease. The compounds have a neuroprotective effect in that they prevent the aggregation of TDP-43, a neurotoxic...
Published: 9/18/2024
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Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics
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Metal Free Scalable Synthesis of Fluorinated Indole and Benzofuran Structures
This technology is a novel one step method to generate fluorinated aryl groups for use in various other reactions.
Background:
There are few alternative existing methods to treat arrhythmia. Originally, there were a slew of powerful anti arrhythmic drugs on the market which had the potential to treat the cardiovascular condition. However, the majority...
Published: 3/12/2024
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Inventor(s): Jon Njardarson, Edon Vitaku, David Smith
Keywords(s):
Category(s): Technology Classifications > Materials > Processing
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