Invention:
This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner.
Background:
Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. This invention possesses no such drawbacks and creates heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.
Applications:
- Anti-HIV compounds
- Anti-hypertensive compounds
- Analgesics
- Cancer therapeutics
Advantages:
- Cost effective relative to the existing options
- One pot reaction allows for faster turnaround
- Generation of chiral compounds
