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Artificial Membranes Incorporating GPCRs for Label-Free, Electrophysiological Measurements of Ligand-GPCR Interactions
This invention consists of an artificial lipid membrane that incorporates G-protein coupled receptors into its structure. It allows direct, label-free measurement of ligand binding and activation of G-protein coupled receptors.
Background:
G-protein coupled receptors are a superfamily of proteins that are very popular drug targets. In 2017, 34%...
Published: 3/12/2024
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Inventor(s): Steven Scott Saavedra, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Screening assays
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Curriculum Materials for the Education of Graduate Level Measurement Science
This technology is an analytical kit for perform analytical chemistry course experiments. This kit is an all-inclusive curriculum platform including compact, integrated hardware with signal processing, data recording, and experimental guide.
Background:
Currently, a large amount of time is used for experimental set-up which is not required for demonstrating...
Published: 3/12/2024
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Inventor(s): Michael Heien, Drew Farrell, Neal Armstrong, Steven Scott Saavedra, Deirdre Belle-Oudry
Keywords(s):
Category(s): Technology Classifications > Creative Works
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A New Method for Preparing Stabilized Lipid Membranes
This invention describes a new straightforward method to prepare stable lipid membranes to maximize its capabilities and usage in the bio/nanotechnology field. The combination of polymer materials via this new polymerization technology that provides stabilized membranes enables new bio/nanotechnology platforms to be realized at its full potential.
Background:
Phospholipid...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Steven Scott Saavedra, Saliya Ratnayaka, Leonard Bright
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Materials > Polymers
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Rapid Conductance Based Analysis for Patch Clamp Sensors
This invention is a data acquisition and analysis protocol for ligand-ion channel interactions. The approach allows for the quantification of ligand concentrations in less than 30 milliseconds. This approach can monitor rapid, dynamic chemical processes in a feasible manner.
Background:
Ion channels have been researched as an option for label-free...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Steven Scott Saavedra, Mark Agasid
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Stabilized Vesicle-Functionalized Microparticles for Chemical Separations
This invention relates to bioassay platforms, in particular, pull-down assay platforms using silica core-polymerized phospholipid vesicle shell particles for peptide/protein ligand screening.
Background:
Many physiological or pathological events involve the molecular recognition and binding between a peptide/protein ligand and a specific target on...
Published: 6/20/2024
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Inventor(s): Craig Aspinwall, Jinyan Wang, Kendall Sandy, Steven Scott Saavedra, Boying Liang, Christopher Baker, Elyssia Gallagher
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation
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Lipid Membranes Enabling MALDI-TOF Mass Spectrometry Protein Analysis
This technology is the use of planar supported lipid bilayer to create the stability for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) analysis.
Background:
MALDI-TOF is an effective method to detect biological analytes from complex samples. MALDI-TOF MS is effective to extract biological analytes...
Published: 3/12/2024
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Inventor(s): Steven Scott Saavedra, Boying Liang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics
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Polymerization of Lipid Assemblies in Aqueous Solution at Neutral pH
This invention is a novel method to induce radical polymerization in lipids in a neutral pH environment, preserving protein bioactivity. It utilizes a different set of reagents than a typical radical polymerization. This invention provides compounds comprising a triazenylidene moiety and methods for producing and using such compounds.
Background:...
Published: 3/12/2024
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Inventor(s): Steven Scott Saavedra, Saliya Ratnayaka, Elyssia Gallagher, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Materials > Polymers
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Stabilized Black Lipid Membranes Prepared via Polymer Scaffolding
This invention presents a new approach for stabilizing black lipid membranes (BLMs) relying on inexpensive commercially available materials. Here, a method is employed that chemically modifies the lipid membrane to dramatically improve BLM stability.
Background:
Black lipid membranes (BLMs), are synthetic membranes used to measure ion channel activity....
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Leonard Bright, Steven Scott Saavedra
Keywords(s):
Category(s): Technology Classifications > Materials > Polymers
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