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Human Skin-on-a-Chip for Modeling Pressure-Induced Injury and Quantitative Immune Responses for Pre-Clinical Safety
This invention is a full-thickness, immune-responsive human skin-on-a-chip platform designed to model pressure-induced injury and quantitatively assess inflammatory toxicity, barrier dysfunction, and immunogenic response. The platform will function as a next-generation New Approach Method (NAM) supporting pre-clinical safety decision-making and reducing...
Published: 5/18/2026
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Updated: 5/18/2026
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Inventor(s): Carlos Zgheib, Kenneth Liechty, Melisa Kafali
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Simulators and Modeling Tools
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CD64+ AND CD14+ Cell Replacement Therapy for Wound Healing
This technology is a cell-based therapy involving an administered dose of cells expressing both CD64+ and CD14+ ligands. It is designed to promote healing in diabetic patients, with potential to reduce inflammation and support tissue regeneration. The cells can be observed in tissue, blood, and bone marrow, allowing for broader variety in addressing...
Published: 3/18/2026
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Updated: 9/15/2025
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Inventor(s): Geoffrey Gurtner, Kellen Chen, Katharina Berryman, Maria Gracia Mora Pinos
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Δ-cps1 Mutant as a Target to Detect Coccidioides Immunity
This technology is a diagnostic platform that utilizes Flow Link Immunosorbent Assay (FLISA) and Δ-cps1, a live attenuated strain of Coccidioides posadasii, to detect if an individual (including animals) has mounted a response to coccidioidomycosis either from infection or vaccination. Δ-cps1 can be used as a stimulus to detect cellular...
Published: 10/10/2025
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Updated: 8/11/2025
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Inventor(s): Daniel Powell, Lisa Shubitz, Marc Orbach, John Galgiani
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Veterinary Medicine > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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AI-Assisted Computational Prediction of Protein Functionality
This invention centers on creating a database and algorithms to explore protein functionality and interactions. The aim is to enable significant scientific discoveries, novel drug targeting, and the engineering of synthetic receptors like chimeric antigen receptors (CARs). By studying proteins involved in T cell activation over 450 million years of...
Published: 4/17/2025
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Updated: 4/17/2025
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Inventor(s): Michael Kuhns, Koenraad Van Doorslaer, Kevin Scott, Andrew Girvin
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
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Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides
This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner.
Background:
Fusing...
Published: 3/5/2025
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Updated: 3/5/2025
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Inventor(s): Michael Kuhns, Mark Lee, Deepta Bhattacharya
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Oncology
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HLA-C Single Chain Trimers to Prevent Natural Killer Cell-Mediated Rejection
This invention is for a method of genetic modification of major histocompatibility complex (MCH) component for prevention of natural killer (NK) cell recognition of pluripotent stem cell grafts using HLA-C trimers. This new method works to overcome immunological rejection by the recipient via genetic modification of these cells.
Background:
As of...
Published: 10/10/2025
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Updated: 12/20/2024
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Inventor(s): Deepta Bhattacharya, Hannah Pizzato
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics
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Novel Mouse Strain for Inflammation and Neurodegeneration
This invention is a transgenic mouse model for the study of multiple sclerosis and rheumatoid arthritis. This new model crosses an HLA transgenic strain with a humanized apolipoprotein E (APOE) mouse model to create a useful tool for studying a wide array of neurodegenerative diseases, specifically the role of T-cell mediated inflammation. This new...
Published: 6/25/2024
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Updated: 6/25/2024
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Inventor(s): Roberta Brinton, Kathleen Rodgers, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
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A Recombinant Protein to Restore the Anti-Cancer Activity of Immune Cells
This invention is a recombinant protein that is designed to restore the activity of immune cells that have been exhausted in patients with cancer. This invention focuses specifically on the restoration of the anti-cancer activity of immune cells, in particular natural killer (NK) cells.
Background:
Immune cell-based therapies are a widely utilized...
Published: 7/26/2024
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Updated: 4/13/2023
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Inventor(s): Youngwook Won, Seungmin Han, David Bull
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Peptide-Based Modulators of HMGBl Activity Protect Against Cell Damage and Inflammation
This technology assists with the inhibition of HMGB1 to decrease the body’s inflammatory response, which occurs when the HMGB1 protein binds to DNA and TLR4. By decreasing HMGB1 binding to DNA, cell inflammation can be significantly reduced, thus preventing further cell damage. This technology can be used in a large spectrum of diseases, such...
Published: 8/16/2023
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Updated: 5/5/2022
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Inventor(s): Ruslan Rafikov, Olga Rafikova
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
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Novel Antibiotic Drug Combination Including an Anti-Inflammatory Metabolite
This technology involves a combination of a metabolite, 3-hydroxyanthanilic acid (3HAA) with a compound that alters cellular iron homeostasis (e.g. an iron chelator or an iron supplement) that produces synergistic antibiotic interaction. 3HAA sensitizes bacteria to changes in iron availability (both increasing iron media content through supplementation...
Published: 1/19/2025
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Updated: 11/12/2021
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Inventor(s): George Sutphin, Luis Espejo
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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