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Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides

This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner. Background: Fusing...

Published: 3/5/2025 | Inventor(s): Michael Kuhns, Mark Lee, Deepta Bhattacharya

Keywords(s):

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Oncology

Tools And Techniques To Identify Antigen-Specific T Cells

This invention is a new tool and technique for identification of antigen-specific t cells. By using specific molecules from specified cell lines as antigen presenting cells, the identified T cells are labeled with different fluorescence. These cells go through the flow cytometry and the flow cytometry data is analyzed by a specific assay designed by...

Published: 11/1/2024 | Inventor(s): Michael Kuhns, Bradley Moffett, Caleb Kim, Mark Lee

Keywords(s):

Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Life Sciences