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Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides

This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner. Background: Fusing...

Published: 3/5/2025 | Inventor(s): Michael Kuhns, Mark Lee, Deepta Bhattacharya

Keywords(s):

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Oncology

HLA-C Single Chain Trimers to Prevent Natural Killer Cell-Mediated Rejection

This invention is for a method of genetic modification of major histocompatibility complex (MCH) component for prevention of natural killer (NK) cell recognition of pluripotent stem cell grafts using HLA-C trimers. This new method works to overcome immunological rejection by the recipient via genetic modification of these cells. Background: As of...

Published: 1/21/2025 | Inventor(s): Deepta Bhattacharya, Hannah Pizzato

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics