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Methods to Differentiate Naive and Pluripotent Stem Cell-Derived B Cells into Plasma Cells
This invention is a method to generate plasma cells from primary and stem cell-derived B cells and includes characterization of cellular intermediates during the maturation process.
Background:
The inefficient generation of plasma cells from primary naïve B cells is due to a combination of intrinsic cellular limitations and external signaling...
Published: 9/22/2025
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Inventor(s): Deepta Bhattacharya, Colin Fields
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Stem Cells, Technology Classifications > Research Tools > Cell Lines
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Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides
This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner.
Background:
Fusing...
Published: 3/5/2025
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Inventor(s): Michael Kuhns, Mark Lee, Deepta Bhattacharya
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Oncology
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HLA-C Single Chain Trimers to Prevent Natural Killer Cell-Mediated Rejection
This invention is for a method of genetic modification of major histocompatibility complex (MCH) component for prevention of natural killer (NK) cell recognition of pluripotent stem cell grafts using HLA-C trimers. This new method works to overcome immunological rejection by the recipient via genetic modification of these cells.
Background:
As of...
Published: 10/10/2025
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Inventor(s): Deepta Bhattacharya, Hannah Pizzato
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics
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