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Novel, Humanized Transgenic Background Mouse Strain for Neurodegenerative Disease Research

This invention is a transgenic mouse model for the study of neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. This new model crosses a humanized APOE mouse model with a humanized APP gene, both common implicated genetic factors in Alzheimer’s Disease. The technology also developed a Parkinson’s Disease specific...

Published: 6/25/2024 | Inventor(s): Roberta Brinton, Jean Paul Wiegand, Lisa Campbell

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology

Novel Mouse Strain for Inflammation and Neurodegeneration

This invention is a transgenic mouse model for the study of multiple sclerosis and rheumatoid arthritis. This new model crosses an HLA transgenic strain with a humanized apolipoprotein E (APOE) mouse model to create a useful tool for studying a wide array of neurodegenerative diseases, specifically the role of T-cell mediated inflammation. This new...

Published: 6/25/2024 | Inventor(s): Roberta Brinton, Kathleen Rodgers, Jean Paul Wiegand, Lisa Campbell

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation