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Novel Mouse Strain for Inflammation and Neurodegeneration
This invention is a transgenic mouse model for the study of multiple sclerosis and rheumatoid arthritis. This new model crosses an HLA transgenic strain with a humanized apolipoprotein E (APOE) mouse model to create a useful tool for studying a wide array of neurodegenerative diseases, specifically the role of T-cell mediated inflammation. This new...
Published: 6/25/2024
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Inventor(s): Roberta Brinton, Kathleen Rodgers, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
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Treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) with a Polypeptide
The SARS-CoV-2 virus binds to ACE2, a cell surface protein receptor. The ACE2 binding reduces the ability of ACE2 to break down Angiotensin-II (Ang-II). Ang-II is a potent vasoconstrictor that can increase lung injury and lung edema, increase blood pressure, and can be harmful to organ function at high concentrations.
This technology administers a...
Published: 11/16/2023
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Inventor(s): Kathleen Rodgers, Sairam Parthasarathy, Gere deZerega
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Development of Aptamers Neutralizing Antibodies for Demyelinating Diseases
This innovation is research involving the development of aptamers that work to neutralize antibodies which harm the myelin sheath of nerves. The innovation can be a successful treatment for both multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIPD). These aptamers will be very specific to block certain autoantibodies...
Published: 4/3/2023
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Inventor(s): May Khanna, Kathleen Rodgers, Maira Soto, Niloufar Mollasalehi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules
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