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Treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) with a Polypeptide

The SARS-CoV-2 virus binds to ACE2, a cell surface protein receptor. The ACE2 binding reduces the ability of ACE2 to break down Angiotensin-II (Ang-II). Ang-II is a potent vasoconstrictor that can increase lung injury and lung edema, increase blood pressure, and can be harmful to organ function at high concentrations. This technology administers a...

Published: 11/16/2023 | Inventor(s): Kathleen Rodgers, Sairam Parthasarathy, Gere deZerega

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases

Development of Aptamers Neutralizing Antibodies for Demyelinating Diseases

This innovation is research involving the development of aptamers that work to neutralize antibodies which harm the myelin sheath of nerves. The innovation can be a successful treatment for both multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIPD). These aptamers will be very specific to block certain autoantibodies...

Published: 4/3/2023 | Inventor(s): May Khanna, Kathleen Rodgers, Maira Soto, Niloufar Mollasalehi

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Category(s): Technology Classifications > Life Sciences > Small Molecules