|
Novel, Humanized Transgenic Background Mouse Strain for Neurodegenerative Disease Research
This invention is a transgenic mouse model for the study of neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. This new model crosses a humanized APOE mouse model with a humanized APP gene, both common implicated genetic factors in Alzheimer’s Disease. The technology also developed a Parkinson’s Disease specific...
Published: 6/25/2024
|
Inventor(s): Roberta Brinton, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology
|
|
Novel Mouse Strain for Inflammation and Neurodegeneration
This invention is a transgenic mouse model for the study of multiple sclerosis and rheumatoid arthritis. This new model crosses an HLA transgenic strain with a humanized apolipoprotein E (APOE) mouse model to create a useful tool for studying a wide array of neurodegenerative diseases, specifically the role of T-cell mediated inflammation. This new...
Published: 6/25/2024
|
Inventor(s): Roberta Brinton, Kathleen Rodgers, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
|
|
Sex and APOE Genotype Precision Therapeutic Targets Discovery for Alzheimer’s Disease
This technology encompasses a formulation for patient subgroup-specific supplement for the treatment and therapy of Alzheimer's and other neurodegenerative diseases. These formulations can range in delivery method (food, drink, pill) and can be specific to patient subgroups.
Background:
Alzheimer’s disease is a progressive, neurodegenerative...
Published: 4/24/2024
|
Inventor(s): Rui Chang, Roberta Brinton, Rima Kaddurah-Daouk
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
|
|
Novel Knockout Model Of ER-Beta in Rat Neurons
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta-FloxP-Cre rat that has ER-beta knocked out specifically in neurons.
Background:
Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack...
Published: 11/16/2023
|
Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
|
|
Novel Knockout Model Of ER-Alpha in Rat Neurons
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha-FloxP-Cre rat that has ER-alpha knocked out specifically in neurons.
Background:
Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack...
Published: 11/16/2023
|
Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
|
|
Novel Forebrain Neuron Specific CreERT2 Rat Model
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors. This specific rat model is forebrain neuron-specific CreERT2 rat model under the CamKII promoter.
Background:
Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models...
Published: 11/16/2023
|
Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
|
|
Novel Conditional Knockout Model Of ER-Beta in Rats
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta FloxP rat that can be combined with tissue-specific Cre rats to generate ER-beta knockouts in any tissues expressing the estrogen receptor.
Background:
Progress in determining the role...
Published: 11/16/2023
|
Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
|
|
Novel Conditional Knockout Model of ER-Alpha in Rats
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha FloxP rat that can be combined with tissue-specific Cre rats to generate ER-alpha knockouts in any tissues expressing the estrogen receptor.
Background:
Progress in determining the role...
Published: 11/16/2023
|
Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools > Animal Models
|
